上村 健太朗
Uemura Kentaro
感染症総合教育研究拠点，特任助教（常勤）
学歴
- 2019年04月 ～ 2022年03月，北海道大学，大学院生命科学院，生命科学専攻 生命医薬科学コース
- 2015年04月 ～ 2017年03月，大阪大学，大学院生命機能研究科
- 2011年04月 ～ 2015年03月，近畿大学，薬学部，創薬科学科
経歴
- 2022年04月 ～ 継続中，大阪大学，感染症総合教育研究拠点／微生物病研究所，特任助教
- 2017年04月 ～ 2022年03月，塩野義製薬株式会社，医薬研究本部 創薬疾患研究所，研究員
研究内容・専門分野
- ライフサイエンス，薬系化学、創薬科学
- ライフサイエンス，ウイルス学
論文
- 2-thiouridine is a broad-spectrum antiviral nucleoside analogue against positive-strand RNA viruses.，Kentaro Uemura,Haruaki Nobori,Akihiko Sato,Shinsuke Toba,Shinji Kusakabe,Michihito Sasaki,Koshiro Tabata,Keita Matsuno,Naoyoshi Maeda,Shiori Ito,Mayu Tanaka,Yuki Anraku,Shunsuke Kita,Mayumi Ishii,Kayoko Kanamitsu,Yasuko Orba,Yoshiharu Matsuura,William W Hall,Hirofumi Sawa,Hiroshi Kida,Akira Matsuda,Katsumi Maenaka，Proceedings of the National Academy of Sciences of the United States of America，Vol. 120，No. 42，2023年10月13日，研究論文（学術雑誌）
- Electrolyzed hypochlorous acid water exhibits potent disinfectant activity against various viruses through irreversible protein aggregation.，Rahmi Dianty,Junki Hirano,Itsuki Anzai,Yuta Kanai,Tsuyoshi Hayashi,Masae Morimoto,Chikako Kataoka-Nakamura,Sakura Kobayashi,Kentaro Uemura,Chikako Ono,Tokiko Watanabe,Takeshi Kobayashi,Kosuke Murakami,Kenji Kikuchi,Kunimoto Hotta,Toshikazu Yoshikawa,Shuhei Taguwa,Yoshiharu Matsuura，Frontiers in microbiology，Vol. 14，p. 1284274-1284274，2023年10月，研究論文（学術雑誌）
- S-217622, a SARS-CoV-2 main protease inhibitor, decreases viral load and ameliorates COVID-19 severity in hamsters.，Michihito Sasaki,Koshiro Tabata,Mai Kishimoto,Yukari Itakura,Hiroko Kobayashi,Takuma Ariizumi,Kentaro Uemura,Shinsuke Toba,Shinji Kusakabe,Yuki Maruyama,Shun Iida,Noriko Nakajima,Tadaki Suzuki,Shinpei Yoshida,Haruaki Nobori,Takao Sanaki,Teruhisa Kato,Takao Shishido,William W Hall,Yasuko Orba,Akihiko Sato,Hirofumi Sawa，Science translational medicine，American Association for the Advancement of Science (AAAS)，Vol. 15，No. 679，2023年01月18日，研究論文（学術雑誌）
- Highly Potent and Oral Macrocyclic Peptides as a HIV-1 Protease Inhibitor: mRNA Display-Derived Hit-to-Lead Optimization.，Yoshifumi Kusumoto,Kyohei Hayashi,Soichiro Sato,Toru Yamada,Iori Kozono,Zenzaburo Nakata,Naoya Asada,Shungo Mitsuki,Ayahisa Watanabe,Chiaki Wakasa-Morimoto,Kentaro Uemura,Shuhei Arita,Shinobu Miki,Tohru Mizutare,Hidenori Mikamiyama，ACS medicinal chemistry letters，American Chemical Society (ACS)，Vol. 13，No. 10，p. 1634-1641，2022年10月13日，研究論文（学術雑誌）
- Isolation and characterization of an orthoreovirus from Indonesian fruit bats.，Kittiya Intaruck,Yukari Itakura,Mai Kishimoto,Herman M Chambaro,Agus Setiyono,Ekowati Handharyani,Kentaro Uemura,Hayato Harima,Satoshi Taniguchi,Masayuki Saijo,Takashi Kimura,Yasuko Orba,Hirofumi Sawa,Michihito Sasaki，Virology，Vol. 575，p. 10-19，2022年10月，研究論文（学術雑誌）
- Identification of cap-dependent endonuclease inhibitors with broad-spectrum activity against bunyaviruses.，Shinsuke Toba,Akihiko Sato,Makoto Kawai,Yoshiyuki Taoda,Yuto Unoh,Shinji Kusakabe,Haruaki Nobori,Shota Uehara,Kentaro Uemura,Keiichi Taniguchi,Masanori Kobayashi,Takeshi Noshi,Ryu Yoshida,Akira Naito,Takao Shishido,Junki Maruyama,Slobodan Paessler,Michael J Carr,William W Hall,Kumiko Yoshimatsu,Jiro Arikawa,Keita Matsuno,Yoshihiro Sakoda,Michihito Sasaki,Yasuko Orba,Hirofumi Sawa,Hiroshi Kida，Proceedings of the National Academy of Sciences of the United States of America，Vol. 119，No. 36，2022年09月06日，研究論文（学術雑誌）
- Serological characterization of lineage II insect-specific flaviviruses compared with pathogenic mosquito-borne flaviviruses.，Koshiro Tabata,Yukari Itakura,Shinsuke Toba,Kentaro Uemura,Mai Kishimoto,Michihito Sasaki,Jessica J Harrison,Akihiko Sato,William W Hall,Roy A Hall,Hirofumi Sawa,Yasuko Orba，Biochemical and biophysical research communications，Vol. 616，p. 115-121，2022年08月06日，研究論文（学術雑誌）
- Efficacy of ensitrelvir against SARS-CoV-2 in a delayed-treatment mouse model.，Haruaki Nobori,Keita Fukao,Takayuki Kuroda,Naomi Anan,Ryoichi Tashima,Masaaki Nakashima,Sayuri Noda,Minako Tajiri,Mikinori Torii,Shinsuke Toba,Kentaro Uemura,Takao Sanaki,Takao Shishido,Yuki Tachibana,Teruhisa Kato，The Journal of antimicrobial chemotherapy，Vol. 77，No. 11，p. 2984-2991，2022年08月01日，研究論文（学術雑誌）
- Discovery of S-217622, a Noncovalent Oral SARS-CoV-2 3CL Protease Inhibitor Clinical Candidate for Treating COVID-19.，Yuto Unoh,Shota Uehara,Kenji Nakahara,Haruaki Nobori,Yukiko Yamatsu,Shiho Yamamoto,Yuki Maruyama,Yoshiyuki Taoda,Koji Kasamatsu,Takahiro Suto,Kensuke Kouki,Atsufumi Nakahashi,Sho Kawashima,Takao Sanaki,Shinsuke Toba,Kentaro Uemura,Tohru Mizutare,Shigeru Ando,Michihito Sasaki,Yasuko Orba,Hirofumi Sawa,Akihiko Sato,Takafumi Sato,Teruhisa Kato,Yuki Tachibana，Journal of medicinal chemistry，American Chemical Society (ACS)，Vol. 65，No. 9，p. 6499-6512，2022年05月12日，研究論文（学術雑誌）
- Pocket-to-Lead: Structure-Based De Novo Design of Novel Non-peptidic HIV-1 Protease Inhibitors Using the Ligand Binding Pocket as a Template.，Eiichi Kojima,Atsuhiro Iimuro,Mado Nakajima,Hirotaka Kinuta,Naoya Asada,Yusuke Sako,Zenzaburo Nakata,Kentaro Uemura,Shuhei Arita,Shinobu Miki,Chiaki Wakasa-Morimoto,Yuki Tachibana，Journal of medicinal chemistry，American Chemical Society (ACS)，Vol. 65，No. 8，p. 6157-6170，2022年04月28日，研究論文（学術雑誌）
- Synthesis and Anti-dengue Virus Activity of 5-Ethynylimidazole-4-carboxamide (EICA) Nucleotide Prodrugs，Motoki Nakamura,Kentaro Uemura,Noriko Saito-Tarashima,Akihiko Sato,Yasuko Orba,Hirofumi Sawa,Akira Matsuda,Katsumi Maenaka,Noriaki Minakawa，Chemical and Pharmaceutical Bulletin，Pharmaceutical Society of Japan，Vol. 70，No. 3，p. 220-225，2022年03月01日，研究論文（学術雑誌）
- Air-liquid interphase culture confers SARS-CoV-2 susceptibility to A549 alveolar epithelial cells，Michihito Sasaki,Mai Kishimoto,Yukari Itakura,Koshiro Tabata,Kittiya Intaruck,Kentaro Uemura,Shinsuke Toba,Takao Sanaki,Akihiko Sato,William W. Hall,Yasuko Orba,Hirofumi Sawa，Biochemical and Biophysical Research Communications，Elsevier BV，Vol. 577，p. 146-151，2021年11月05日，研究論文（学術雑誌）
- 5-Hydroxymethyltubercidin exhibits potent antiviral activity against flaviviruses and coronaviruses, including SARS-CoV-2，Kentaro Uemura,Haruaki Nobori,Akihiko Sato,Takao Sanaki,Shinsuke Toba,Michihito Sasaki,Akiho Murai,Noriko Saito-Tarashima,Noriaki Minakawa,Yasuko Orba,Hiroaki Kariwa,William W. Hall,Hirofumi Sawa,Akira Matsuda,Katsumi Maenaka，iScience，Elsevier BV，Vol. 24，No. 10，p. 103120-103120，2021年10月22日，研究論文（学術雑誌）
- SARS-CoV-2 Bearing a Mutation at the S1/S2 Cleavage Site Exhibits Attenuated Virulence and Confers Protective Immunity，Michihito Sasaki,Shinsuke Toba,Yukari Itakura,Herman M. Chambaro,Mai Kishimoto,Koshiro Tabata,Kittiya Intaruck,Kentaro Uemura,Takao Sanaki,Akihiko Sato,William W. Hall,Yasuko Orba,Hirofumi Sawa，mBio，American Society for Microbiology，Vol. 12，No. 4，2021年08月31日，研究論文（学術雑誌）
- Host Serine Proteases TMPRSS2 and TMPRSS11D Mediate Proteolytic Activation and Trypsin-Independent Infection in Group A Rotaviruses，Michihito Sasaki,Yukari Itakura,Mai Kishimoto,Koshiro Tabata,Kentaro Uemura,Naoto Ito,Makoto Sugiyama,Christida E. Wastika,Yasuko Orba,Hirofumi Sawa，Journal of Virology，American Society for Microbiology，Vol. 95，No. 11，2021年05月10日，研究論文（学術雑誌）
- MRC5 cells engineered to express ACE2 serve as a model system for the discovery of antivirals targeting SARS-CoV-2.，Kentaro Uemura,Michihito Sasaki,Takao Sanaki,Shinsuke Toba,Yoshimasa Takahashi,Yasuko Orba,William W Hall,Katsumi Maenaka,Hirofumi Sawa,Akihiko Sato，Scientific reports，Vol. 11，No. 1，p. 5376-5376，2021年03月08日，研究論文（学術雑誌）
- An African tick flavivirus forming an independent clade exhibits unique exoribonuclease-resistant RNA structures in the genomic 3'-untranslated region.，Hayato Harima,Yasuko Orba,Shiho Torii,Yongjin Qiu,Masahiro Kajihara,Yoshiki Eto,Naoya Matsuta,Bernard M Hang'ombe,Yuki Eshita,Kentaro Uemura,Keita Matsuno,Michihito Sasaki,Kentaro Yoshii,Ryo Nakao,William W Hall,Ayato Takada,Takashi Abe,Michael T Wolfinger,Martin Simuunza,Hirofumi Sawa，Scientific reports，Vol. 11，No. 1，p. 4883-4883，2021年03月01日，研究論文（学術雑誌）
- TMPRSS11D and TMPRSS13 Activate the SARS-CoV-2 Spike Protein.，Mai Kishimoto,Kentaro Uemura,Takao Sanaki,Akihiko Sato,William W Hall,Hiroaki Kariwa,Yasuko Orba,Hirofumi Sawa,Michihito Sasaki，Viruses，Vol. 13，No. 3，2021年02月28日，研究論文（学術雑誌）
- SARS-CoV-2 variants with mutations at the S1/S2 cleavage site are generated in vitro during propagation in TMPRSS2-deficient cells.，Michihito Sasaki,Kentaro Uemura,Akihiko Sato,Shinsuke Toba,Takao Sanaki,Katsumi Maenaka,William W Hall,Yasuko Orba,Hirofumi Sawa，PLoS pathogens，Vol. 17，No. 1，2021年01月，研究論文（学術雑誌）
- Identification of quinolone derivatives as effective anti-Dengue virus agents，Haruaki Nobori,Kentaro Uemura,Shinsuke Toba,Takao Sanaki,Takao Shishido,William W. Hall,Yasuko Orba,Hirofumi Sawa,Akihiko Sato，Antiviral Research，Elsevier BV，Vol. 184，p. 104969-104969，2020年12月，研究論文（学術雑誌）
- Suppression of HBV replication by the expression of nickase-and nuclease dead-Cas9，Takeshi Kurihara,Takasuke Fukuhara,Chikako Ono,Satomi Yamamoto,Kentaro Uemura,Toru Okamoto,Masaya Sugiyama,Daisuke Motooka,Shota Nakamura,Masato Ikawa,Masashi Mizokami,Yoshihiko Maehara,Yoshiharu Matsuura，Scientific Reports，Vol. 7，No. 1，2017年12月01日，研究論文（学術雑誌）
- Characterization of miR-122-independent propagation of HCV，Chikako Ono,Takasuke Fukuhara,Daisuke Motooka,Shota Nakamura,Daisuke Okuzaki,Satomi Yamamoto,Tomokazu Tamura,Hiroyuki Mori,Asuka Sato,Kentaro Uemura,Yuzy Fauzyah,Takeshi Kurihara,Takahiro Suda,Akira Nishio,Su Su Hmwe,Toru Okamoto,Tomohide Tatsumi,Tetsuo Takehara,Kazuaki Chayama,Takaji Wakita,Kazuhiko Koike,Yoshiharu Matsuura，PLoS Pathogens，Vol. 13，No. 5，2017年05月，研究論文（学術雑誌）
- Host-derived apolipoproteins play comparable roles with viral secretory proteins E<sup>rns</sup>and NS1 in the infectious particle formation of Flaviviridae，Takasuke Fukuhara,Tomokazu Tamura,Chikako Ono,Mai Shiokawa,Hiroyuki Mori,Kentaro Uemura,Satomi Yamamoto,Takeshi Kurihara,Toru Okamoto,Ryosuke Suzuki,Kentaro Yoshii,Takeshi Kurosu,Manabu Igarashi,Hiroshi Aoki,Yoshihiro Sakoda,Yoshiharu Matsuura，PLoS Pathogens，Vol. 13，No. 6，2017年，研究論文（学術雑誌）
- Human cathelicidin compensates for the role of apolipoproteins in hepatitis C virus infectious particle formation，Francesc Puig-Basagoiti,Takasuke Fukuhara,Tomokazu Tamura,Chikako Ono,Kentaro Uemura,Yukako Kawachi,Satomi Yamamoto,Hiroyuki Mori,Takeshi Kurihara,Toru Okamoto,Hideki Aizaki,Yoshiharu Matsuura，Journal of Virology，Vol. 90，No. 19，p. 8464-8477，2016年10月，研究論文（学術雑誌）
- Lipoprotein Receptors Redundantly Participate in Entry of Hepatitis C Virus，Satomi Yamamoto,Takasuke Fukuhara,Chikako Ono,Kentaro Uemura,Yukako Kawachi,Mai Shiokawa,Hiroyuki Mori,Masami Wada,Ryoichi Shima,Toru Okamoto,Nobuhiko Hiraga,Ryosuke Suzuki,Kazuaki Chayama,Takaji Wakita,Yoshiharu Matsuura，PLoS Pathogens，Vol. 12，No. 5，2016年05月，研究論文（学術雑誌）
- Optimization of Method to Extract Collagen from "Emperor" Tissue of Soft-shelled Turtles，Yamamoto Tetsushi,Uemura Kentaro,Sawashi Yuki,Mitamura Kuniko,Taga Atsushi，Journal of Oleo Science，公益社団法人 日本油化学会，Vol. 65，No. 2，p. 169-175，2016年，研究論文（学術雑誌）
- Inhibitory effect of maple syrup on the cell growth and invasion of human colorectal cancer cells，TETSUSHI YAMAMOTO,KENTARO UEMURA,KAHO MORIYAMA,KUNIKO MITAMURA,ATSUSHI TAGA，Oncology Reports，Spandidos Publications，Vol. 33，No. 4，p. 1579-1584，2015年04月，研究論文（学術雑誌）
講演・口頭発表等
- Identification of a broad-spectrum antiviral nucleoside analogue against positive-strand RNA viruses，上村 健太朗，The 21st Awaji International Forum on Infection and Immunity，2023年09月
- Identification of a broad-spectrum antiviral nucleoside analogue against positive-strand RNA viruses，上村 健太朗，ASV2023，2023年06月
- プラス鎖RNAウイルスに対して広域的に抗ウイルス活性を示すヌクレオシドアナログの探索，上村 健太朗,登 治謙,佐藤 彰彦,鳥羽 晋輔,日下部 伸治,佐々木 道仁,田畑 耕史郎,大場 靖子,澤 洋文,松浦 善治,松田 彰,前仲 勝実，第69回日本ウイルス学会学術集会，2022年11月