Hokkaido University Graduate School of Life Science Biomedical and Pharmaceutical Science Course, Division of Life Science
2019/04 - 2022/03
Osaka University Graduate School of Frontier Biosciences
2015/04 - 2017/03
Kindai University Faculty of Pharmacy Department of Pharmaceutical Sciences
2011/04 - 2015/03
American Society for Virology
日本薬学会
日本ウイルス学会
Life sciences / Pharmaceuticals - chemistry and drug development /
Life sciences / Virology /
2024年度 日本薬学会関西支部奨励賞
日本薬学会関西支部 2025/01
ASV 2023 Travel Award
American Society for Virology 2023/06
Enterovirus 3A protein disrupts endoplasmic reticulum homeostasis through interaction with GBF1
Junki Hirano, Tsuyoshi Hayashi, Kouichi Kitamura, Yorihiro Nishimura, Hiroyuki Shimizu, Toru Okamoto, Kazuma Okada, Kentaro Uemura, Ming Te Yeh, Chikako Ono, Shuhei Taguwa, Masamichi Muramatsu, Yoshiharu Matsuura
Journal of Virology Vol. 98 No. 7 2024/07/23 Research paper (scientific journal)
Publisher: American Society for Microbiology
2-thiouridine is a broad-spectrum antiviral nucleoside analogue against positive-strand RNA viruses.
Kentaro Uemura, Haruaki Nobori, Akihiko Sato, Shinsuke Toba, Shinji Kusakabe, Michihito Sasaki, Koshiro Tabata, Keita Matsuno, Naoyoshi Maeda, Shiori Ito, Mayu Tanaka, Yuki Anraku, Shunsuke Kita, Mayumi Ishii, Kayoko Kanamitsu, Yasuko Orba, Yoshiharu Matsuura, William W Hall, Hirofumi Sawa, Hiroshi Kida, Akira Matsuda, Katsumi Maenaka
Proceedings of the National Academy of Sciences of the United States of America Vol. 120 No. 42 2023/10/13 Research paper (scientific journal)
Electrolyzed hypochlorous acid water exhibits potent disinfectant activity against various viruses through irreversible protein aggregation.
Rahmi Dianty, Junki Hirano, Itsuki Anzai, Yuta Kanai, Tsuyoshi Hayashi, Masae Morimoto, Chikako Kataoka-Nakamura, Sakura Kobayashi, Kentaro Uemura, Chikako Ono, Tokiko Watanabe, Takeshi Kobayashi, Kosuke Murakami, Kenji Kikuchi, Kunimoto Hotta, Toshikazu Yoshikawa, Shuhei Taguwa, Yoshiharu Matsuura
Frontiers in microbiology Vol. 14 p. 1284274-1284274 2023/10/01 Research paper (scientific journal)
S-217622, a SARS-CoV-2 main protease inhibitor, decreases viral load and ameliorates COVID-19 severity in hamsters.
Michihito Sasaki, Koshiro Tabata, Mai Kishimoto, Yukari Itakura, Hiroko Kobayashi, Takuma Ariizumi, Kentaro Uemura, Shinsuke Toba, Shinji Kusakabe, Yuki Maruyama, Shun Iida, Noriko Nakajima, Tadaki Suzuki, Shinpei Yoshida, Haruaki Nobori, Takao Sanaki, Teruhisa Kato, Takao Shishido, William W Hall, Yasuko Orba, Akihiko Sato, Hirofumi Sawa
Science translational medicine Vol. 15 No. 679 2023/01/18 Research paper (scientific journal)
Publisher: American Association for the Advancement of Science (AAAS)
Highly Potent and Oral Macrocyclic Peptides as a HIV-1 Protease Inhibitor: mRNA Display-Derived Hit-to-Lead Optimization.
Yoshifumi Kusumoto, Kyohei Hayashi, Soichiro Sato, Toru Yamada, Iori Kozono, Zenzaburo Nakata, Naoya Asada, Shungo Mitsuki, Ayahisa Watanabe, Chiaki Wakasa-Morimoto, Kentaro Uemura, Shuhei Arita, Shinobu Miki, Tohru Mizutare, Hidenori Mikamiyama
ACS medicinal chemistry letters Vol. 13 No. 10 p. 1634-1641 2022/10/13 Research paper (scientific journal)
Publisher: American Chemical Society (ACS)
Isolation and characterization of an orthoreovirus from Indonesian fruit bats.
Kittiya Intaruck, Yukari Itakura, Mai Kishimoto, Herman M Chambaro, Agus Setiyono, Ekowati Handharyani, Kentaro Uemura, Hayato Harima, Satoshi Taniguchi, Masayuki Saijo, Takashi Kimura, Yasuko Orba, Hirofumi Sawa, Michihito Sasaki
Virology Vol. 575 p. 10-19 2022/10 Research paper (scientific journal)
Identification of cap-dependent endonuclease inhibitors with broad-spectrum activity against bunyaviruses.
Shinsuke Toba, Akihiko Sato, Makoto Kawai, Yoshiyuki Taoda, Yuto Unoh, Shinji Kusakabe, Haruaki Nobori, Shota Uehara, Kentaro Uemura, Keiichi Taniguchi, Masanori Kobayashi, Takeshi Noshi, Ryu Yoshida, Akira Naito, Takao Shishido, Junki Maruyama, Slobodan Paessler, Michael J Carr, William W Hall, Kumiko Yoshimatsu, Jiro Arikawa, Keita Matsuno, Yoshihiro Sakoda, Michihito Sasaki, Yasuko Orba, Hirofumi Sawa, Hiroshi Kida
Proceedings of the National Academy of Sciences of the United States of America Vol. 119 No. 36 2022/09/06 Research paper (scientific journal)
Serological characterization of lineage II insect-specific flaviviruses compared with pathogenic mosquito-borne flaviviruses.
Koshiro Tabata, Yukari Itakura, Shinsuke Toba, Kentaro Uemura, Mai Kishimoto, Michihito Sasaki, Jessica J Harrison, Akihiko Sato, William W Hall, Roy A Hall, Hirofumi Sawa, Yasuko Orba
Biochemical and biophysical research communications Vol. 616 p. 115-121 2022/08/06 Research paper (scientific journal)
Efficacy of ensitrelvir against SARS-CoV-2 in a delayed-treatment mouse model.
Haruaki Nobori, Keita Fukao, Takayuki Kuroda, Naomi Anan, Ryoichi Tashima, Masaaki Nakashima, Sayuri Noda, Minako Tajiri, Mikinori Torii, Shinsuke Toba, Kentaro Uemura, Takao Sanaki, Takao Shishido, Yuki Tachibana, Teruhisa Kato
The Journal of antimicrobial chemotherapy Vol. 77 No. 11 p. 2984-2991 2022/08/01 Research paper (scientific journal)
Discovery of S-217622, a Noncovalent Oral SARS-CoV-2 3CL Protease Inhibitor Clinical Candidate for Treating COVID-19.
Yuto Unoh, Shota Uehara, Kenji Nakahara, Haruaki Nobori, Yukiko Yamatsu, Shiho Yamamoto, Yuki Maruyama, Yoshiyuki Taoda, Koji Kasamatsu, Takahiro Suto, Kensuke Kouki, Atsufumi Nakahashi, Sho Kawashima, Takao Sanaki, Shinsuke Toba, Kentaro Uemura, Tohru Mizutare, Shigeru Ando, Michihito Sasaki, Yasuko Orba, Hirofumi Sawa, Akihiko Sato, Takafumi Sato, Teruhisa Kato, Yuki Tachibana
Journal of medicinal chemistry Vol. 65 No. 9 p. 6499-6512 2022/05/12 Research paper (scientific journal)
Publisher: American Chemical Society (ACS)
Pocket-to-Lead: Structure-Based De Novo Design of Novel Non-peptidic HIV-1 Protease Inhibitors Using the Ligand Binding Pocket as a Template.
Eiichi Kojima, Atsuhiro Iimuro, Mado Nakajima, Hirotaka Kinuta, Naoya Asada, Yusuke Sako, Zenzaburo Nakata, Kentaro Uemura, Shuhei Arita, Shinobu Miki, Chiaki Wakasa-Morimoto, Yuki Tachibana
Journal of medicinal chemistry Vol. 65 No. 8 p. 6157-6170 2022/04/28 Research paper (scientific journal)
Publisher: American Chemical Society (ACS)
Synthesis and Anti-dengue Virus Activity of 5-Ethynylimidazole-4-carboxamide (EICA) Nucleotide Prodrugs
Motoki Nakamura, Kentaro Uemura, Noriko Saito-Tarashima, Akihiko Sato, Yasuko Orba, Hirofumi Sawa, Akira Matsuda, Katsumi Maenaka, Noriaki Minakawa
Chemical and Pharmaceutical Bulletin Vol. 70 No. 3 p. 220-225 2022/03/01 Research paper (scientific journal)
Publisher: Pharmaceutical Society of Japan
Air-liquid interphase culture confers SARS-CoV-2 susceptibility to A549 alveolar epithelial cells
Michihito Sasaki, Mai Kishimoto, Yukari Itakura, Koshiro Tabata, Kittiya Intaruck, Kentaro Uemura, Shinsuke Toba, Takao Sanaki, Akihiko Sato, William W. Hall, Yasuko Orba, Hirofumi Sawa
Biochemical and Biophysical Research Communications Vol. 577 p. 146-151 2021/11/05 Research paper (scientific journal)
Publisher: Elsevier BV
5-Hydroxymethyltubercidin exhibits potent antiviral activity against flaviviruses and coronaviruses, including SARS-CoV-2
Kentaro Uemura, Haruaki Nobori, Akihiko Sato, Takao Sanaki, Shinsuke Toba, Michihito Sasaki, Akiho Murai, Noriko Saito-Tarashima, Noriaki Minakawa, Yasuko Orba, Hiroaki Kariwa, William W. Hall, Hirofumi Sawa, Akira Matsuda, Katsumi Maenaka
iScience Vol. 24 No. 10 p. 103120-103120 2021/10/22 Research paper (scientific journal)
Publisher: Elsevier BV
SARS-CoV-2 Bearing a Mutation at the S1/S2 Cleavage Site Exhibits Attenuated Virulence and Confers Protective Immunity
Michihito Sasaki, Shinsuke Toba, Yukari Itakura, Herman M. Chambaro, Mai Kishimoto, Koshiro Tabata, Kittiya Intaruck, Kentaro Uemura, Takao Sanaki, Akihiko Sato, William W. Hall, Yasuko Orba, Hirofumi Sawa
mBio Vol. 12 No. 4 2021/08/31 Research paper (scientific journal)
Publisher: American Society for Microbiology
Host Serine Proteases TMPRSS2 and TMPRSS11D Mediate Proteolytic Activation and Trypsin-Independent Infection in Group A Rotaviruses
Michihito Sasaki, Yukari Itakura, Mai Kishimoto, Koshiro Tabata, Kentaro Uemura, Naoto Ito, Makoto Sugiyama, Christida E. Wastika, Yasuko Orba, Hirofumi Sawa
Journal of Virology Vol. 95 No. 11 2021/05/10 Research paper (scientific journal)
Publisher: American Society for Microbiology
MRC5 cells engineered to express ACE2 serve as a model system for the discovery of antivirals targeting SARS-CoV-2.
Kentaro Uemura, Michihito Sasaki, Takao Sanaki, Shinsuke Toba, Yoshimasa Takahashi, Yasuko Orba, William W Hall, Katsumi Maenaka, Hirofumi Sawa, Akihiko Sato
Scientific reports Vol. 11 No. 1 p. 5376-5376 2021/03/08 Research paper (scientific journal)
An African tick flavivirus forming an independent clade exhibits unique exoribonuclease-resistant RNA structures in the genomic 3'-untranslated region.
Hayato Harima, Yasuko Orba, Shiho Torii, Yongjin Qiu, Masahiro Kajihara, Yoshiki Eto, Naoya Matsuta, Bernard M Hang'ombe, Yuki Eshita, Kentaro Uemura, Keita Matsuno, Michihito Sasaki, Kentaro Yoshii, Ryo Nakao, William W Hall, Ayato Takada, Takashi Abe, Michael T Wolfinger, Martin Simuunza, Hirofumi Sawa
Scientific reports Vol. 11 No. 1 p. 4883-4883 2021/03/01 Research paper (scientific journal)
TMPRSS11D and TMPRSS13 Activate the SARS-CoV-2 Spike Protein.
Mai Kishimoto, Kentaro Uemura, Takao Sanaki, Akihiko Sato, William W Hall, Hiroaki Kariwa, Yasuko Orba, Hirofumi Sawa, Michihito Sasaki
Viruses Vol. 13 No. 3 2021/02/28 Research paper (scientific journal)
SARS-CoV-2 variants with mutations at the S1/S2 cleavage site are generated in vitro during propagation in TMPRSS2-deficient cells.
Michihito Sasaki, Kentaro Uemura, Akihiko Sato, Shinsuke Toba, Takao Sanaki, Katsumi Maenaka, William W Hall, Yasuko Orba, Hirofumi Sawa
PLoS pathogens Vol. 17 No. 1 2021/01 Research paper (scientific journal)
Identification of quinolone derivatives as effective anti-Dengue virus agents
Haruaki Nobori, Kentaro Uemura, Shinsuke Toba, Takao Sanaki, Takao Shishido, William W. Hall, Yasuko Orba, Hirofumi Sawa, Akihiko Sato
Antiviral Research Vol. 184 p. 104969-104969 2020/12 Research paper (scientific journal)
Publisher: Elsevier BV
Suppression of HBV replication by the expression of nickase-and nuclease dead-Cas9
Takeshi Kurihara, Takasuke Fukuhara, Chikako Ono, Satomi Yamamoto, Kentaro Uemura, Toru Okamoto, Masaya Sugiyama, Daisuke Motooka, Shota Nakamura, Masato Ikawa, Masashi Mizokami, Yoshihiko Maehara, Yoshiharu Matsuura
Scientific Reports Vol. 7 No. 1 2017/12/01 Research paper (scientific journal)
Characterization of miR-122-independent propagation of HCV
Chikako Ono, Takasuke Fukuhara, Daisuke Motooka, Shota Nakamura, Daisuke Okuzaki, Satomi Yamamoto, Tomokazu Tamura, Hiroyuki Mori, Asuka Sato, Kentaro Uemura, Yuzy Fauzyah, Takeshi Kurihara, Takahiro Suda, Akira Nishio, Su Su Hmwe, Toru Okamoto, Tomohide Tatsumi, Tetsuo Takehara, Kazuaki Chayama, Takaji Wakita, Kazuhiko Koike, Yoshiharu Matsuura
PLoS Pathogens Vol. 13 No. 5 2017/05 Research paper (scientific journal)
Host-derived apolipoproteins play comparable roles with viral secretory proteins Ernsand NS1 in the infectious particle formation of Flaviviridae
Takasuke Fukuhara, Tomokazu Tamura, Chikako Ono, Mai Shiokawa, Hiroyuki Mori, Kentaro Uemura, Satomi Yamamoto, Takeshi Kurihara, Toru Okamoto, Ryosuke Suzuki, Kentaro Yoshii, Takeshi Kurosu, Manabu Igarashi, Hiroshi Aoki, Yoshihiro Sakoda, Yoshiharu Matsuura
PLoS Pathogens Vol. 13 No. 6 2017 Research paper (scientific journal)
Human cathelicidin compensates for the role of apolipoproteins in hepatitis C virus infectious particle formation
Francesc Puig-Basagoiti, Takasuke Fukuhara, Tomokazu Tamura, Chikako Ono, Kentaro Uemura, Yukako Kawachi, Satomi Yamamoto, Hiroyuki Mori, Takeshi Kurihara, Toru Okamoto, Hideki Aizaki, Yoshiharu Matsuura
Journal of Virology Vol. 90 No. 19 p. 8464-8477 2016/10 Research paper (scientific journal)
Lipoprotein Receptors Redundantly Participate in Entry of Hepatitis C Virus
Satomi Yamamoto, Takasuke Fukuhara, Chikako Ono, Kentaro Uemura, Yukako Kawachi, Mai Shiokawa, Hiroyuki Mori, Masami Wada, Ryoichi Shima, Toru Okamoto, Nobuhiko Hiraga, Ryosuke Suzuki, Kazuaki Chayama, Takaji Wakita, Yoshiharu Matsuura
PLoS Pathogens Vol. 12 No. 5 2016/05 Research paper (scientific journal)
Optimization of Method to Extract Collagen from “Emperor” Tissue of Soft-shelled Turtles
Tetsushi Yamamoto, Kentaro Uemura, Yuki Sawashi, Kuniko Mitamura, Atsushi Taga
Journal of Oleo Science Vol. 65 No. 2 p. 169-175 2016 Research paper (scientific journal)
Publisher: Japan Oil Chemists' Society
Inhibitory effect of maple syrup on the cell growth and invasion of human colorectal cancer cells
TETSUSHI YAMAMOTO, KENTARO UEMURA, KAHO MORIYAMA, KUNIKO MITAMURA, ATSUSHI TAGA
Oncology Reports Vol. 33 No. 4 p. 1579-1584 2015/04 Research paper (scientific journal)
Publisher: Spandidos Publications
Generation of severe COVID-19 mouse model by treatment with Cyclophosphamide
日下部伸治, 日下部伸治, 鳥羽晋輔, 鳥羽晋輔, 井澤政明, 丸山優樹, 丸山優樹, 上村健太朗, 上村健太朗, 上村健太朗, 宍戸貴雄, 佐々木道仁, 大場靖子, 澤洋文, 澤洋文, 佐藤彰彦, 佐藤彰彦, 佐藤彰彦
日本ウイルス学会学術集会プログラム・予稿集(Web) Vol. 70th 2023
Mechanism of severe COVID-19 regulated by amino acid mutations in non-structural proteins
岸本麻衣, 岸本麻衣, 鳥羽晋輔, 鳥羽晋輔, 上村健太朗, 上村健太朗, 上村健太朗, 丸山優樹, 丸山優樹, 日下部伸治, 日下部伸治, 佐藤彰彦, 佐藤彰彦, 佐藤彰彦, 大場靖子, 澤洋文, 澤洋文, 佐々木道仁
日本ウイルス学会学術集会プログラム・予稿集(Web) Vol. 70th 2023
Discovery of a broad-spectrum antiviral nucleoside analogue against positive-strand RNA viruses
上村健太朗, 上村健太朗, 上村健太朗, 上村健太朗, 上村健太朗, 登治謙, 佐藤彰彦, 佐藤彰彦, 佐藤彰彦, 鳥羽晋輔, 鳥羽晋輔, 日下部伸治, 日下部伸治, 佐々木道仁, 田畑耕史郎, 大場靖子, 澤洋文, 澤洋文, 松浦善治, 松浦善治, 松田彰, 前仲勝実, 前仲勝実, 前仲勝実
日本薬学会年会要旨集(Web) Vol. 143rd 2023
細胞内プロテアーゼ活性測定系を用いたウイルスプロテアーゼ阻害剤の探索
上村 健太朗, 平野 順紀, 岡田 和真, 小野 慎子, 田鍬 修平, 松浦 善治
日本薬学会 第145年回 2025/03
細胞内プロテアーゼ活性測定系を用いたエンテロウイルス3Cプロテアーゼ阻害剤の探索
上村 健太朗, 平野 順紀, 岡田 和真, 小野 慎子, 田鍬 修平, 松浦 善治
第71回日本ウイルス学会学術集会 2024/11
一本鎖プラス鎖RNAウイルスに対する広域抗ウイルス剤の同定 ―2-Thiouridineはプラス鎖RNAウイルスの増殖を特異的に阻害する―
上村 健太朗, 登 治謙, 佐藤 彰彦, 鳥羽 晋輔, 日下部 伸治, 佐々木 道仁, 大場 靖子, 澤 洋文, 松浦 善治, 松田 彰, 前仲 勝実
第74回日本薬学会関西支部総会・大会 2024/10
Identification of inhibitors for enterovirus 3C protease using cell-based protease assay
Kentaro Uemura, Junki Hirano, Kazuma Okada, Chikako Ono, Shuhei Taguwa, Yoshiharu Matsuura
43rd Annual Meeting of American Society for Virology (ASV2024) 2024/06
Identification of a broad-spectrum antiviral nucleoside analogue against positive-strand RNA viruses
2023/09
Identification of a broad-spectrum antiviral nucleoside analogue against positive-strand RNA viruses
Kentaro Uemura, Haruaki Nobori, Akihiko Sato, Shinsuke Toba, Shinji Kusakabe, Michihito Sasaki, Yasuko Orba, Yoshiharu Matsuura, Hirofumi Sawa, Akira Matsuda, Katsumi Maenaka
42nd Annual Meeting of American Society for Virology (ASV2023) 2023/06
プラス鎖 RNAウイルスに対して広域的に抗ウイルス活性を示すヌクレオシドアナログの探索
上村 健太朗, 登 治謙, 佐藤 彰彦, 鳥羽 晋輔, 日下部 伸治, 佐々木 道仁, 田畑 耕史郎, 大場 靖子, 澤 洋文, 松浦 善治, 松田 彰, 前仲 勝実
日本薬学会 第143年回 2023/03
プラス鎖RNAウイルスに対して広域的に抗ウイルス活性を示すヌクレオシドアナログの探索
上村 健太朗, 登 治謙, 佐藤 彰彦, 鳥羽 晋輔, 日下部 伸治, 佐々木 道仁, 田畑 耕史郎, 大場 靖子, 澤 洋文, 松浦 善治, 松田 彰, 前仲 勝実
第69回日本ウイルス学会学術集会 2022/11
