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基本情報

研究

社会活動

その他の活動

中川 拓郎

Nakagawa Takuro

理学研究科 生物科学専攻,准教授

takuro4 bio.sci.osaka-u.ac.jp

keyword DNA複製,分裂酵母,セントロメア,染色体,DNA組換え

学歴

  • 1995年04月 ~ 1998年03月,大阪大学,大学院理学研究科,生理学専攻(後期)
  • 1993年04月 ~ 1995年03月,大阪大学,大学院理学研究科,生理学専攻(前期)
  • 1989年04月 ~ 1993年03月,大阪大学,理学部,生物学科

経歴

  • 2011年02月 ~ 継続中,大阪大学,大学院理学研究科,准教授
  • 2007年04月 ~ 2011年01月,大阪大学,大学院理学研究科,助教
  • 2000年08月 ~ 2007年03月,大阪大学,大学院理学研究科,助手
  • 1998年05月 ~ 2000年07月,カリフォルニア大学サンディエゴ校(UCSD),ポスドク

研究内容・専門分野

  • ライフサイエンス,分子生物学
  • ライフサイエンス,遺伝学

所属学会

  • 日本遺伝学会
  • 日本分子生物学会

論文

  • Fission yeast Rad8/HLTF facilitates Rad52-dependent chromosomal rearrangements through PCNA lysine 107 ubiquitination.,Jie Su,Ran Xu,Piyusha Mongia,Naoko Toyofuku,Takuro Nakagawa,PLoS genetics,Vol. 17,No. 7,2021年07月,研究論文(学術雑誌)
  • DNA replication machinery prevents Rad52-dependent single-strand annealing that leads to gross chromosomal rearrangements at centromeres.,Atsushi T Onaka,Jie Su,Yasuhiro Katahira,Crystal Tang,Faria Zafar,Keita Aoki,Wataru Kagawa,Hironori Niki,Hiroshi Iwasaki,Takuro Nakagawa,Communications biology,Vol. 3,2020年04月30日,研究論文(学術雑誌)
  • Transcriptional silencing of centromere repeats by heterochromatin safeguards chromosome integrity.,Nakagawa T,Okita AK,Current Genetics,Springer Nature,Vol. 65,No. 5,p. 1089-1098,2019年10月,研究論文(学術雑誌)
  • Heterochromatin suppresses gross chromosomal rearrangements at centromeres by repressing Tfs1/TFIIS-dependent transcription.,Akiko K Okita,Faria Zafar,Jie Su,Dayalini Weerasekara,Takuya Kajitani,Tatsuro S Takahashi,Hiroshi Kimura,Yota Murakami,Hisao Masukata,Takuro Nakagawa,Communications biology,Vol. 2,p. 17-17,2019年01月,研究論文(学術雑誌)
  • Regulation of mitotic recombination between DNA repeats in centromeres,Faria Zafar,Akiko K Okita,Atsushi T Onaka,Jie Su,Yasuhiro Katahira,Jun-ichi Nakayama,Tatsuro S Takahashi,Hisao Masukata,Takuro Nakagawa,Nucleic Acids Research,Oxford University Press (OUP),Vol. 45,No. 19,p. 11222-11235,2017年11月02日,研究論文(学術雑誌)
  • Rad51 and Rad54 promote noncrossover recombination between centromere repeats on the same chromatid to prevent isochromosome formation,Atsushi T. Onaka,Naoko Toyofuku,Takahiro Inoue,Akiko K. Okita,Minami Sagawa,Jie Su,Takeshi Shitanda,Rei Matsuyama,Faria Zafar,Tatsuro S. Takahashi,Hisao Masukata,Takuro Nakagawa,NUCLEIC ACIDS RESEARCH,OXFORD UNIV PRESS,Vol. 44,No. 22,p. 10744-10757,2016年12月,研究論文(学術雑誌)
  • Abundance of Prereplicative Complexes (Pre-RCs) Facilitates Recombinational Repair under Replication Stress in Fission Yeast,Journal of Biological Chemistry,Vol. 286,No. 48,p. 41701-41710,2011年12月,研究論文(学術雑誌)
  • Rad51 suppresses gross chromosomal rearrangement at centromere in Schizosaccharomyces pombe,Ken-ichi Nakamura,Aya Okamoto,Yuki Katou,Chie Yadani,Takeshi Shitanda,Chitrada Kaweeteerawat,Tatsuro S. Takahashi,Takehiko Itoh,Katsuhiko Shirahige,Hisao Masukata,Takuro Nakagawa,EMBO JOURNAL,WILEY,Vol. 27,No. 22,p. 3036-3046,2008年11月,研究論文(学術雑誌)
  • Mcm4 C-terminal domain of MCM helicase prevents excessive formation of single-stranded DNA at stalled replication forks,Naoki Nitani,Chie Yadani,Hayato Yabuuchi,Hisao Masukata,Takuro Nakagawa,PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,NATL ACAD SCIENCES,Vol. 105,No. 35,p. 12973-12978,2008年09月,研究論文(学術雑誌)
  • Regulation of DNA replication machinery by Mrc1 in fission yeast,Naoki Nitani,Ken-ichi Nakamura,Chie Nakagawa,Hisao Masukata,Takuro Nakagawa,GENETICS,GENETICS,Vol. 174,No. 1,p. 155-165,2006年09月,研究論文(学術雑誌)
  • Saccharomyces cerevisiae MER3 helicase stimulates 3 '-5 ' Heteroduplex extension by Rad51: Implications for crossover control in meiotic recombination,OM Mazina,AV Mazin,T Nakagawa,RD Kolodner,SC Kowalczykowski,CELL,CELL PRESS,Vol. 117,No. 1,p. 47-56,2004年04月,研究論文(学術雑誌)
  • The MER3 DNA helicase catalyzes the unwinding of Holliday junctions,T Nakagawa,RD Kolodner,JOURNAL OF BIOLOGICAL CHEMISTRY,AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC,Vol. 277,No. 31,p. 28019-28024,2002年08月,研究論文(学術雑誌)
  • Saccharomyces cerevisiae Mer3 is a DNA helicase involved in meiotic crossing over,T Nakagawa,RD Kolodner,MOLECULAR AND CELLULAR BIOLOGY,AMER SOC MICROBIOLOGY,Vol. 22,No. 10,p. 3281-3291,2002年05月,研究論文(学術雑誌)
  • The MER3 helicase involved in meiotic crossing over is stimulated by single-stranded DNA-binding proteins and unwinds DNA in the 3 ' to 5 ' direction,T Nakagawa,H Flores-Rozas,RD Kolodner,JOURNAL OF BIOLOGICAL CHEMISTRY,AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC,Vol. 276,No. 34,p. 31487-31493,2001年08月,研究論文(学術雑誌)
  • Multiple functions of MutS- and MutL-related heterocomplexes,T Nakagawa,A Datta,RD Kolodner,PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,NATL ACAD SCIENCES,Vol. 96,No. 25,p. 14186-14188,1999年12月
  • The Saccharomyces cerevisiae MER3 gene, encoding a novel helicase-like protein, is required for crossover control in meiosis,T Nakagawa,H Ogawa,EMBO JOURNAL,OXFORD UNIV PRESS,Vol. 18,No. 20,p. 5714-5723,1999年10月,研究論文(学術雑誌)
  • Involvement of the MRE2 gene of yeast in formation of meiosis-specific double-strand breaks and crossover recombination through RNA splicing,T Nakagawa,H Ogawa,GENES TO CELLS,WILEY-BLACKWELL,Vol. 2,No. 1,p. 65-79,1997年01月,研究論文(学術雑誌)
  • Functions of the yeast meiotic recombination genes, MRE11 and MRE2,Ogawa H,Johzuka K,Nakagawa T,Leem SH,Hagihara AH,Advances in Biophysics,Elsevier BV,Vol. 31,p. 67-76,1995年,研究論文(学術雑誌)
  • Shelterin promotes tethering of late replication origins to telomeres for replication‐timing control,Shiho Ogawa,Sayuri Kido,Tetsuya Handa,Hidesato Ogawa,Haruhiko Asakawa,Tatsuro S Takahashi,Takuro Nakagawa,Yasushi Hiraoka,Hisao Masukata,The EMBO Journal,EMBO,Vol. 37,No. 15,2018年08月,研究論文(学術雑誌)
  • Nucleosomes around a mismatched base pair are excluded via an Msh2-dependent reaction with the aid of SNF2 family ATPase Smarcad1,Riki Terui,Koji Nagao,Yoshitaka Kawasoe,Kanae Taki,Torahiko L. Higashi,Seiji Tanaka,Takuro Nakagawa,Chikashi Obuse,Hisao Masukata,Tatsuro S. Takahashi,Genes and Development,Cold Spring Harbor Laboratory Press,Vol. 32,No. 11-12,p. 806-821,2018年06月01日,研究論文(学術雑誌)
  • MutSα maintains the mismatch repair capability by inhibiting PCNA unloading,Kawasoe Y,Tsurimoto T,Nakagawa T,Masukata H,Takahashi T.S,eLife,Vol. 5,2016年07月,研究論文(学術雑誌)
  • The DNA damage checkpoint pathway promotes extensive resection and nucleotide synthesis to facilitate homologous recombination repair and genome stability in fission yeast,Elizabeth J. Blaikley,Helen Tinline-Purvis,Torben R. Kasparek,Samuel Marguerat,Sovan Sarkar,Lydia Hulme,Sharon Hussey,Boon-Yu Wee,Rachel S. Deegan,Carol A. Walker,Chen-Chun Pai,Juerg Baehler,Takuro Nakagawa,Timothy C. Humphrey,NUCLEIC ACIDS RESEARCH,OXFORD UNIV PRESS,Vol. 42,No. 9,p. 5644-5656,2014年,研究論文(学術雑誌)
  • Telomere-binding protein Taz1 controls global replication timing through its localization near late replication origins in fission yeast,Atsutoshi Tazumi,Masayoshi Fukuura,Ryuichiro Nakato,Ami Kishimoto,Tomokazu Takenaka,Shiho Ogawa,Ji-hoon Song,Tatsuro S. Takahashi,Takuro Nakagawa,Katsuhiko Shirahige,Hisao Masukata,GENES & DEVELOPMENT,COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT,Vol. 26,No. 18,p. 2050-2062,2012年09月,研究論文(学術雑誌)
  • DNA polymerization-independent functions of DNA polymerase epsilon in assembly and progression of the replisome in fission yeast,Tetsuya Handa,Mai Kanke,Tatsuro S. Takahashi,Takuro Nakagawa,Hisao Masukata,MOLECULAR BIOLOGY OF THE CELL,AMER SOC CELL BIOLOGY,Vol. 23,No. 16,p. 3240-3253,2012年08月,研究論文(学術雑誌)
  • The Prereplication Complex Recruits XEco2 to Chromatin to Promote Cohesin Acetylation in Xenopus Egg Extracts,Torahiko L. Higashi,Megumi Ikeda,Hiroshi Tanaka,Takuro Nakagawa,Masashige Bando,Katsuhiko Shirahige,Yumiko Kubota,Haruhiko Takisawa,Hisao Masukata,Tatsuro S. Takahashi,CURRENT BIOLOGY,CELL PRESS,Vol. 22,No. 11,p. 977-988,2012年06月,研究論文(学術雑誌)
  • Mcm10 plays an essential role in origin DNA unwinding after loading of the CMG components,Mai Kanke,Yukako Kodama,Tatsuro S. Takahashi,Takuro Nakagawa,Hisao Masukata,EMBO JOURNAL,NATURE PUBLISHING GROUP,Vol. 31,No. 9,p. 2182-2194,2012年05月,研究論文(学術雑誌)
  • CDK promotes interactions of Sld3 and Drc1 with Cut5 for initiation of DNA replication in fission yeast,Masayoshi Fukuura,Koji Nagao,Chikashi Obuse,Tatsuro S. Takahashi,Takuro Nakagawa,Hisao Masukata,MOLECULAR BIOLOGY OF THE CELL,AMER SOC CELL BIOLOGY,Vol. 22,No. 14,p. 2620-2633,2011年07月,研究論文(学術雑誌)
  • Auxin-inducible protein depletion system in fission yeast,Mai Kanke,Kohei Nishimura,Kohei Nishimura,Masato Kanemaki,Masato Kanemaki,Tatsuo Kakimoto,Tatsuro S. Takahashi,Takuro Nakagawa,Hisao Masukata,BMC Cell Biology,Vol. 12, 8, doi:10.1186/1471-2121-12-8,2011年02月11日
  • The heterochromatin protein Swi6/HP1 activates replication origins at the pericentromeric region and silent mating-type locus,Makoto T. Hayashi,Tatsuro S. Takahashi,Takuro Nakagawa,Jun-ichi Nakayama,Hisao Masukata,NATURE CELL BIOLOGY,NATURE PUBLISHING GROUP,Vol. 11,No. 3,p. 357-U284,2009年03月,研究論文(学術雑誌)
  • Genome-wide localization of pre-RC sites and identification of replication origins in fission yeast,Makoto Hayashi,Yuki Katou,Takehiko Itoh,Mitsutoshi Tazumi,Yoshiki Yamada,Tatsuro Takahashi,Takuro Nakagawa,Katsuhiko Shirahige,Hisao Masukata,EMBO JOURNAL,NATURE PUBLISHING GROUP,Vol. 26,No. 5,p. 1327-1339,2007年03月,研究論文(学術雑誌)
  • Ordered assembly of Sld3, GINS and Cdc45 is distinctly regulated by DDK and CDK for activation of replication origins,Hayato Yabuuchi,Yoshiki Yamada,Tomonori Uchida,Tul Sunathvanichkul,Takuro Nakagawa,Hisao Masukata,EMBO JOURNAL,WILEY,Vol. 25,No. 19,p. 4663-4674,2006年10月,研究論文(学術雑誌)
  • A novel intermediate in initiation complex assembly for fission yeast DNA replication,Y Yamada,T Nakagawa,H Masukata,MOLECULAR BIOLOGY OF THE CELL,AMER SOC CELL BIOLOGY,Vol. 15,No. 8,p. 3740-3750,2004年08月,研究論文(学術雑誌)
  • A novel allele of fission yeast rad11 that causes defects in DNA repair and telomere length regulation,Y Ono,K Tomita,A Matsuura,T Nakagawa,H Masukata,M Uritani,T Ushimaru,M Ueno,NUCLEIC ACIDS RESEARCH,OXFORD UNIV PRESS,Vol. 31,No. 24,p. 7141-7149,2003年12月,研究論文(学術雑誌)
  • A novel allele of fission yeast radii that causes defects in DNA repair and telomere length regulation,Ono Y,Tomita K,Matsuura A,Nakagawa T,Masukata H,Uritani M,Ushimaru T,Ueno M,KURRI Progress Report,2003年

MISC

  • Rad51 and Rad54 promote noncrossover recombination between centromere repeats to prevent isochromosome formation,Takuro Nakagawa,Atsushi Onaka,Tatsuro S. Takahashi,Hisao Masukata,GENES & GENETIC SYSTEMS,GENETICS SOC JAPAN,Vol. 91,No. 6,p. 372-372,2016年12月,研究発表ペーパー・要旨(国際会議)
  • Fission yeast CENP-T nucleosomes promote the isochromosome formation in centromere,Jie Su,Akiko Okita,Tatsuro Takahashi,Hisao Masukata,Takuro Nakagawa,GENES & GENETIC SYSTEMS,GENETICS SOC JAPAN,Vol. 90,No. 6,p. 377-377,2015年12月,研究発表ペーパー・要旨(国際会議)
  • Molecular mechanism of gross chromosomal rearrangements in centromere,Takuro Nakagawa,GENES & GENETIC SYSTEMS,GENETICS SOC JAPAN,Vol. 89,No. 6,p. 283-283,2014年12月,研究発表ペーパー・要旨(国際会議)
  • The centromere integrity is maintained through the function of kinetochore proteins CENP-SX,Takuro Nakagawa,GENES & GENETIC SYSTEMS,GENETICS SOC JAPAN,Vol. 88,No. 6,p. 340-340,2013年12月,研究発表ペーパー・要旨(国際会議)
  • Recombination between the centromere repeats in fission yeast.,Shitanda T,Asai R,Zafar F,Inoue T,Katahira Y,Takahashi TS,Masukata H,Nakagawa T,2011年06月
  • Recombination between Centromere Repeats in Fission Yeast.,Shitanda T,Asai R,Zafar F,Inoue T,Katahira Y,Takahashi TS,Masukata H,Nakagawa T,2011年01月
  • Non-Crossover Recombination Driven by Rad51 Strand Exchange protein and Rad54 Chromatin Remodeler Predominates in the Fission Yeast Centromere.,Shitanda T,Asai R,Inoue T,Zafar F,Katahira Y,Takahashi TS,Masukata H,Nakagawa T,2010年10月
  • Homologous recombination between centromere repeats in fission yeast.,Nakagawa T,Shitanda T,Asai R,Inoue T,Zafar F,Katahira Y,Takahashi TS,Masukata H,2010年08月
  • Inhibition of nucleosome assembly by the mismatch repair system,Tatsuro Takahashi,Kanae Taki,Torahiko Higashi,Takuro Nakagawa,Hisao Masukata,FASEB JOURNAL,FEDERATION AMER SOC EXP BIOL,Vol. 24,2010年04月,研究発表ペーパー・要旨(国際会議)
  • クロマチン構造による複製開始制御,升方久夫,林眞理,竹中友一,高橋達郎,中川拓郎,中山潤一,生化学,2009年09月25日
  • 分裂酵母染色体テロメア近傍の複製開始制御の解析,竹中友一,林眞理,高橋達郎,中川拓郎,升方久夫,生化学,2008年
  • Genome-wide localization of pre-RC sites and identification of replication origins in fission yeast (vol 26, pg 1327, 2007),Makoto Hayashi,Yuki Katou,Takehiko Itoh,Atsutoshi Tazumi,Yoshiki Yamada,Tatsuro Takahashi,Takuro Nakagawa,Katsuhiko Shirahige,Hisao Masukata,EMBO JOURNAL,NATURE PUBLISHING GROUP,Vol. 26,No. 11,p. 2821-2821,2007年06月

著書

  • 学術書,Fundamental Aspects of DNA Replication,Zafar F,Nakagawa T,InTech, Rijeka, Croatia,ISBN:9789533072593,2011年09月

受賞

  • 奨励賞,日本遺伝学会,2021年08月
  • Reviewer of the Month,Communications Biology (Springer Nature),2020年04月
  • 総長奨励賞(研究部門),大阪大学,2015年
  • 教育・研究功績賞,大阪大学,2009年
  • A long-term fellowship,Human Frontier Science Program,1999年
  • 特別研究員(PD),日本学術振興会,1998年
  • 特別研究員(DC),日本学術振興会,1995年