JA

Profile

Research

Social

Other

Nakagawa Takuro

中川 拓郎

Graduate School of Science Department of Biological Sciences, Associate Professor

takuro4 bio.sci.osaka-u.ac.jp

keyword DNA replication,fission yeast,centromere,chromosome,DNA recombination

Education

  • 1995/04 - 1998/03, Osaka University, Graduate School of Science
  • 1993/04 - 1995/03, Osaka University, Graduate School of Science
  • 1989/04 - 1993/03, Osaka University, School of Science

Research History

  • 2011/02 - Present, Osaka University, Graduate School of Science, Associate Professor
  • 2007/04 - 2011/01, Osaka University, Graduate School of Science, Assistant Professor
  • 2000/08 - 2007/03, Osaka University, Graduate School of Science, Assistant Professor
  • 1998/05 - 2000/07, University of California San Diego (UCSD), Ludwig Institute for Cancer Research, Postdoctoral Fellow

Research Areas

  • Life sciences, Molecular biology
  • Life sciences, Genetics

Professional Memberships

  • THE GENETICS SOCIETY OF JAPAN
  • 日本分子生物学会

Papers

  • DNA replication machinery prevents Rad52-dependent single-strand annealing that leads to gross chromosomal rearrangements at centromeres., Atsushi T Onaka,Jie Su,Yasuhiro Katahira,Crystal Tang,Faria Zafar,Keita Aoki,Wataru Kagawa,Hironori Niki,Hiroshi Iwasaki,Takuro Nakagawa, Communications biology, Vol. 3, 2020/04/30
  • Transcriptional silencing of centromere repeats by heterochromatin safeguards chromosome integrity., Nakagawa T,Okita AK, Current Genetics, Springer Nature, Vol. 65, No. 5, p. 1089-1098, 2019/10
  • Heterochromatin suppresses gross chromosomal rearrangements at centromeres by repressing Tfs1/TFIIS-dependent transcription., Akiko K Okita,Faria Zafar,Jie Su,Dayalini Weerasekara,Takuya Kajitani,Tatsuro S Takahashi,Hiroshi Kimura,Yota Murakami,Hisao Masukata,Takuro Nakagawa, Communications biology, Vol. 2, p. 17-17, 2019/01
  • Shelterin promotes tethering of late replication origins to telomeres for replication‐timing control, Shiho Ogawa,Sayuri Kido,Tetsuya Handa,Hidesato Ogawa,Haruhiko Asakawa,Tatsuro S Takahashi,Takuro Nakagawa,Yasushi Hiraoka,Hisao Masukata, The EMBO Journal, EMBO, Vol. 37, No. 15, 2018/08
  • Nucleosomes around a mismatched base pair are excluded via an Msh2-dependent reaction with the aid of SNF2 family ATPase Smarcad1, Riki Terui,Koji Nagao,Yoshitaka Kawasoe,Kanae Taki,Torahiko L. Higashi,Seiji Tanaka,Takuro Nakagawa,Chikashi Obuse,Hisao Masukata,Tatsuro S. Takahashi, Genes and Development, Cold Spring Harbor Laboratory Press, Vol. 32, No. 11-12, p. 806-821, 2018/06/01
  • Regulation of mitotic recombination between DNA repeats in centromeres, Faria Zafar,Akiko K Okita,Atsushi T Onaka,Jie Su,Yasuhiro Katahira,Jun-ichi Nakayama,Tatsuro S Takahashi,Hisao Masukata,Takuro Nakagawa, Nucleic Acids Research, Oxford University Press (OUP), Vol. 45, No. 19, p. 11222-11235, 2017/11/02
  • Rad51 and Rad54 promote noncrossover recombination between centromere repeats on the same chromatid to prevent isochromosome formation, Atsushi T. Onaka,Naoko Toyofuku,Takahiro Inoue,Akiko K. Okita,Minami Sagawa,Jie Su,Takeshi Shitanda,Rei Matsuyama,Faria Zafar,Tatsuro S. Takahashi,Hisao Masukata,Takuro Nakagawa, NUCLEIC ACIDS RESEARCH, OXFORD UNIV PRESS, Vol. 44, No. 22, p. 10744-10757, 2016/12
  • MutS alpha maintains the mismatch repair capability by inhibiting PCNA unloading, Yoshitaka Kawasoe,Toshiki Tsurimoto,Takuro Nakagawa,Hisao Masukata,Tatsuro S. Takahashi, ELIFE, ELIFE SCIENCES PUBLICATIONS LTD, Vol. 5, 2016/07
  • The DNA damage checkpoint pathway promotes extensive resection and nucleotide synthesis to facilitate homologous recombination repair and genome stability in fission yeast, Elizabeth J. Blaikley,Helen Tinline-Purvis,Torben R. Kasparek,Samuel Marguerat,Sovan Sarkar,Lydia Hulme,Sharon Hussey,Boon-Yu Wee,Rachel S. Deegan,Carol A. Walker,Chen-Chun Pai,Juerg Baehler,Takuro Nakagawa,Timothy C. Humphrey, NUCLEIC ACIDS RESEARCH, OXFORD UNIV PRESS, Vol. 42, No. 9, p. 5644-5656, 2014
  • Telomere-binding protein Taz1 controls global replication timing through its localization near late replication origins in fission yeast, Atsutoshi Tazumi,Masayoshi Fukuura,Ryuichiro Nakato,Ami Kishimoto,Tomokazu Takenaka,Shiho Ogawa,Ji-hoon Song,Tatsuro S. Takahashi,Takuro Nakagawa,Katsuhiko Shirahige,Hisao Masukata, GENES & DEVELOPMENT, COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT, Vol. 26, No. 18, p. 2050-2062, 2012/09
  • DNA polymerization-independent functions of DNA polymerase epsilon in assembly and progression of the replisome in fission yeast, Tetsuya Handa,Mai Kanke,Tatsuro S. Takahashi,Takuro Nakagawa,Hisao Masukata, MOLECULAR BIOLOGY OF THE CELL, AMER SOC CELL BIOLOGY, Vol. 23, No. 16, p. 3240-3253, 2012/08
  • The Prereplication Complex Recruits XEco2 to Chromatin to Promote Cohesin Acetylation in Xenopus Egg Extracts, Torahiko L. Higashi,Megumi Ikeda,Hiroshi Tanaka,Takuro Nakagawa,Masashige Bando,Katsuhiko Shirahige,Yumiko Kubota,Haruhiko Takisawa,Hisao Masukata,Tatsuro S. Takahashi, CURRENT BIOLOGY, CELL PRESS, Vol. 22, No. 11, p. 977-988, 2012/06
  • Mcm10 plays an essential role in origin DNA unwinding after loading of the CMG components, Mai Kanke,Yukako Kodama,Tatsuro S. Takahashi,Takuro Nakagawa,Hisao Masukata, EMBO JOURNAL, NATURE PUBLISHING GROUP, Vol. 31, No. 9, p. 2182-2194, 2012/05
  • Abundance of Prereplicative Complexes (Pre-RCs) Facilitates Recombinational Repair under Replication Stress in Fission Yeast, Kentaro Maki,Takahiro Inoue,Atsushi Onaka,Hiroko Hashizume,Naoko Somete,Yuko Kobayashi,Shigefumi Murakami,Chikako Shigaki,Tatsuro S. Takahashi,Hisao Masukata,Takuro Nakagawa, Journal of Biological Chemistry, Elsevier BV, Vol. 286, No. 48, p. 41701-41710, 2011/12
  • CDK promotes interactions of Sld3 and Drc1 with Cut5 for initiation of DNA replication in fission yeast, Masayoshi Fukuura,Koji Nagao,Chikashi Obuse,Tatsuro S. Takahashi,Takuro Nakagawa,Hisao Masukata, MOLECULAR BIOLOGY OF THE CELL, AMER SOC CELL BIOLOGY, Vol. 22, No. 14, p. 2620-2633, 2011/07
  • Auxin-inducible protein depletion system in fission yeast, Mai Kanke,Kohei Nishimura,Kohei Nishimura,Masato Kanemaki,Masato Kanemaki,Tatsuo Kakimoto,Tatsuro S. Takahashi,Takuro Nakagawa,Hisao Masukata, BMC Cell Biology, Vol. 12, 8, doi:10.1186/1471-2121-12-8, 2011/02/11
  • The heterochromatin protein Swi6/HP1 activates replication origins at the pericentromeric region and silent mating-type locus, Makoto T. Hayashi,Tatsuro S. Takahashi,Takuro Nakagawa,Jun-ichi Nakayama,Hisao Masukata, NATURE CELL BIOLOGY, NATURE PUBLISHING GROUP, Vol. 11, No. 3, p. 357-U284, 2009/03
  • Rad51 suppresses gross chromosomal rearrangement at centromere in Schizosaccharomyces pombe, Ken-ichi Nakamura,Aya Okamoto,Yuki Katou,Chie Yadani,Takeshi Shitanda,Chitrada Kaweeteerawat,Tatsuro S. Takahashi,Takehiko Itoh,Katsuhiko Shirahige,Hisao Masukata,Takuro Nakagawa, EMBO JOURNAL, WILEY, Vol. 27, No. 22, p. 3036-3046, 2008/11
  • Mcm4 C-terminal domain of MCM helicase prevents excessive formation of single-stranded DNA at stalled replication forks, Naoki Nitani,Chie Yadani,Hayato Yabuuchi,Hisao Masukata,Takuro Nakagawa, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, NATL ACAD SCIENCES, Vol. 105, No. 35, p. 12973-12978, 2008/09
  • Genome-wide localization of pre-RC sites and identification of replication origins in fission yeast, Makoto Hayashi,Yuki Katou,Takehiko Itoh,Mitsutoshi Tazumi,Yoshiki Yamada,Tatsuro Takahashi,Takuro Nakagawa,Katsuhiko Shirahige,Hisao Masukata, EMBO JOURNAL, NATURE PUBLISHING GROUP, Vol. 26, No. 5, p. 1327-1339, 2007/03
  • Ordered assembly of Sld3, GINS and Cdc45 is distinctly regulated by DDK and CDK for activation of replication origins, Hayato Yabuuchi,Yoshiki Yamada,Tomonori Uchida,Tul Sunathvanichkul,Takuro Nakagawa,Hisao Masukata, EMBO JOURNAL, WILEY, Vol. 25, No. 19, p. 4663-4674, 2006/10
  • Regulation of DNA replication machinery by Mrc1 in fission yeast, Naoki Nitani,Ken-ichi Nakamura,Chie Nakagawa,Hisao Masukata,Takuro Nakagawa, GENETICS, GENETICS, Vol. 174, No. 1, p. 155-165, 2006/09
  • A novel intermediate in initiation complex assembly for fission yeast DNA replication, Y Yamada,T Nakagawa,H Masukata, MOLECULAR BIOLOGY OF THE CELL, AMER SOC CELL BIOLOGY, Vol. 15, No. 8, p. 3740-3750, 2004/08
  • Saccharomyces cerevisiae MER3 helicase stimulates 3 '-5 ' Heteroduplex extension by Rad51: Implications for crossover control in meiotic recombination, OM Mazina,AV Mazin,T Nakagawa,RD Kolodner,SC Kowalczykowski, CELL, CELL PRESS, Vol. 117, No. 1, p. 47-56, 2004/04
  • A novel allele of fission yeast rad11 that causes defects in DNA repair and telomere length regulation, Y Ono,K Tomita,A Matsuura,T Nakagawa,H Masukata,M Uritani,T Ushimaru,M Ueno, NUCLEIC ACIDS RESEARCH, OXFORD UNIV PRESS, Vol. 31, No. 24, p. 7141-7149, 2003/12
  • A novel allele of fission yeast radii that causes defects in DNA repair and telomere length regulation, Ono Y,Tomita K,Matsuura A,Nakagawa T,Masukata H,Uritani M,Ushimaru T,Ueno M, KURRI Progress Report, 2003
  • The MER3 DNA helicase catalyzes the unwinding of Holliday junctions, T Nakagawa,RD Kolodner, JOURNAL OF BIOLOGICAL CHEMISTRY, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, Vol. 277, No. 31, p. 28019-28024, 2002/08
  • Saccharomyces cerevisiae Mer3 is a DNA helicase involved in meiotic crossing over, T Nakagawa,RD Kolodner, MOLECULAR AND CELLULAR BIOLOGY, AMER SOC MICROBIOLOGY, Vol. 22, No. 10, p. 3281-3291, 2002/05
  • The MER3 helicase involved in meiotic crossing over is stimulated by single-stranded DNA-binding proteins and unwinds DNA in the 3 ' to 5 ' direction, T Nakagawa,H Flores-Rozas,RD Kolodner, JOURNAL OF BIOLOGICAL CHEMISTRY, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, Vol. 276, No. 34, p. 31487-31493, 2001/08
  • Multiple functions of MutS- and MutL-related heterocomplexes, T Nakagawa,A Datta,RD Kolodner, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, NATL ACAD SCIENCES, Vol. 96, No. 25, p. 14186-14188, 1999/12
  • The Saccharomyces cerevisiae MER3 gene, encoding a novel helicase-like protein, is required for crossover control in meiosis, T Nakagawa,H Ogawa, EMBO JOURNAL, OXFORD UNIV PRESS, Vol. 18, No. 20, p. 5714-5723, 1999/10
  • Involvement of the MRE2 gene of yeast in formation of meiosis-specific double-strand breaks and crossover recombination through RNA splicing, T Nakagawa,H Ogawa, GENES TO CELLS, WILEY-BLACKWELL, Vol. 2, No. 1, p. 65-79, 1997/01
  • Functions of the yeast meiotic recombination genes, MRE11 and MRE2, Ogawa H,Johzuka K,Nakagawa T,Leem SH,Hagihara AH, Advances in Biophysics, Elsevier BV, Vol. 31, p. 67-76, 1995

Misc.

  • Rad51 and Rad54 promote noncrossover recombination between centromere repeats to prevent isochromosome formation, Takuro Nakagawa,Atsushi Onaka,Tatsuro S. Takahashi,Hisao Masukata, GENES & GENETIC SYSTEMS, GENETICS SOC JAPAN, Vol. 91, No. 6, p. 372-372, 2016/12
  • Fission yeast CENP-T nucleosomes promote the isochromosome formation in centromere, Jie Su,Akiko Okita,Tatsuro Takahashi,Hisao Masukata,Takuro Nakagawa, GENES & GENETIC SYSTEMS, GENETICS SOC JAPAN, Vol. 90, No. 6, p. 377-377, 2015/12
  • Molecular mechanism of gross chromosomal rearrangements in centromere, Takuro Nakagawa, GENES & GENETIC SYSTEMS, GENETICS SOC JAPAN, Vol. 89, No. 6, p. 283-283, 2014/12
  • The centromere integrity is maintained through the function of kinetochore proteins CENP-SX, Takuro Nakagawa, GENES & GENETIC SYSTEMS, GENETICS SOC JAPAN, Vol. 88, No. 6, p. 340-340, 2013/12
  • Recombination between the centromere repeats in fission yeast., Shitanda T,Asai R,Zafar F,Inoue T,Katahira Y,Takahashi TS,Masukata H,Nakagawa T, 2011/06
  • Recombination between Centromere Repeats in Fission Yeast., Shitanda T,Asai R,Zafar F,Inoue T,Katahira Y,Takahashi TS,Masukata H,Nakagawa T, 2011/01
  • Non-Crossover Recombination Driven by Rad51 Strand Exchange protein and Rad54 Chromatin Remodeler Predominates in the Fission Yeast Centromere., Shitanda T,Asai R,Inoue T,Zafar F,Katahira Y,Takahashi TS,Masukata H,Nakagawa T, 2010/10
  • Homologous recombination between centromere repeats in fission yeast., Nakagawa T,Shitanda T,Asai R,Inoue T,Zafar F,Katahira Y,Takahashi TS,Masukata H, 2010/08
  • Inhibition of nucleosome assembly by the mismatch repair system, Tatsuro Takahashi,Kanae Taki,Torahiko Higashi,Takuro Nakagawa,Hisao Masukata, FASEB JOURNAL, FEDERATION AMER SOC EXP BIOL, Vol. 24, 2010/04
  • クロマチン構造による複製開始制御, 升方久夫,林眞理,竹中友一,高橋達郎,中川拓郎,中山潤一, 生化学, 2009/09/25
  • 分裂酵母染色体テロメア近傍の複製開始制御の解析, 竹中友一,林眞理,高橋達郎,中川拓郎,升方久夫, 生化学, 2008
  • Genome-wide localization of pre-RC sites and identification of replication origins in fission yeast (vol 26, pg 1327, 2007), Makoto Hayashi,Yuki Katou,Takehiko Itoh,Atsutoshi Tazumi,Yoshiki Yamada,Tatsuro Takahashi,Takuro Nakagawa,Katsuhiko Shirahige,Hisao Masukata, EMBO JOURNAL, NATURE PUBLISHING GROUP, Vol. 26, No. 11, p. 2821-2821, 2007/06

Publications

  • Fundamental Aspects of DNA Replication, Zafar F,Nakagawa T, InTech, Rijeka, Croatia, ISBN:9789533072593, 2011/09

Awards

  • Reviewer of the Month, Communications Biology (Springer Nature), 2020/04
  • 総長奨励賞(研究部門), 大阪大学, 2015
  • 教育・研究功績賞, 大阪大学, 2009
  • A long-term fellowship, Human Frontier Science Program, 1999
  • 特別研究員(PD), 日本学術振興会, 1998
  • 特別研究員(DC), 日本学術振興会, 1995