ライフサイエンス / 細菌学 /
ライフサイエンス / 免疫学 /
ライフサイエンス / 消化器内科学 /
Mucolytic bacteria license pathobionts to acquire host-derived nutrients during dietary nutrient restriction.
Kohei Sugihara, Sho Kitamoto, Prakaimuk Saraithong, Hiroko Nagao-Kitamoto, Matthew Hoostal, Caroline McCarthy, Alexandra Rosevelt, Chithra K Muraleedharan, Merritt G Gillilland 3rd, Jin Imai, Maiko Omi, Shrinivas Bishu, John Y Kao, Christopher J Alteri, Nicolas Barnich, Thomas M Schmidt, Asma Nusrat, Naohiro Inohara, Jonathan L Golob, Nobuhiko Kamada
Cell reports Vol. 40 No. 3 p. 111093-111093 2022年7月19日 研究論文（学術雑誌）
A potential pathogenic association between periodontal disease and Crohn's disease.
Jin Imai, Hitoshi Ichikawa, Sho Kitamoto, Jonathan L Golob, Motoki Kaneko, Junko Nagata, Miho Takahashi, Merritt G Gillilland, Rika Tanaka, Hiroko Nagao-Kitamoto, Atsushi Hayashi, Kohei Sugihara, Shrinivas Bishu, Shingo Tsuda, Hiroyuki Ito, Seiichiro Kojima, Kazunari Karakida, Masashi Matsushima, Takayoshi Suzuki, Katsuto Hozumi, Norihito Watanabe, William V Giannobile, Takayuki Shirai, Hidekazu Suzuki, Nobuhiko Kamada
JCI insight Vol. 6 No. 23 2021年10月28日 研究論文（学術雑誌）
The Butyrate-Producing Bacterium Clostridium butyricum Suppresses Clostridioides difficile Infection via Neutrophil- and Antimicrobial Cytokine-Dependent but GPR43/109a-Independent Mechanisms.
Atsushi Hayashi, Hiroko Nagao-Kitamoto, Sho Kitamoto, Chang H Kim, Nobuhiko Kamada
Journal of immunology (Baltimore, Md. : 1950) Vol. 206 No. 7 p. 1576-1585 2021年4月1日 研究論文（学術雑誌）
The Intermucosal Connection between the Mouth and Gut in Commensal Pathobiont-Driven Colitis.
Sho Kitamoto, Hiroko Nagao-Kitamoto, Yizu Jiao, Merritt G Gillilland 3rd, Atsushi Hayashi, Jin Imai, Kohei Sugihara, Mao Miyoshi, Jennifer C Brazil, Peter Kuffa, Brett D Hill, Syed M Rizvi, Fei Wen, Shrinivas Bishu, Naohiro Inohara, Kathryn A Eaton, Asma Nusrat, Yu L Lei, William V Giannobile, Nobuhiko Kamada
Cell Vol. 182 No. 2 p. 447-462 2020年7月23日 研究論文（学術雑誌）
Interleukin-22-mediated host glycosylation prevents Clostridioides difficile infection by modulating the metabolic activity of the gut microbiota.
Hiroko Nagao-Kitamoto, Jhansi L Leslie, Sho Kitamoto, Chunsheng Jin, Kristina A Thomsson, Merritt G Gillilland 3rd, Peter Kuffa, Yoshiyuki Goto, Robert R Jenq, Chiharu Ishii, Akiyoshi Hirayama, Anna M Seekatz, Eric C Martens, Kathryn A Eaton, John Y Kao, Shinji Fukuda, Peter D R Higgins, Niclas G Karlsson, Vincent B Young, Nobuhiko Kamada
Nature medicine Vol. 26 No. 4 p. 608-617 2020年4月 研究論文（学術雑誌）
Dietary L-serine confers a competitive fitness advantage to Enterobacteriaceae in the inflamed gut.
Sho Kitamoto, Christopher J Alteri, Michael Rodrigues, Hiroko Nagao-Kitamoto, Kohei Sugihara, Stephanie D Himpsl, Malak Bazzi, Mao Miyoshi, Tatsuki Nishioka, Atsushi Hayashi, Tina L Morhardt, Peter Kuffa, Helmut Grasberger, Mohamad El-Zaatari, Shrinivas Bishu, Chiharu Ishii, Akiyoshi Hirayama, Kathryn A Eaton, Belgin Dogan, Kenneth W Simpson, Naohiro Inohara, Harry L T Mobley, John Y Kao, Shinji Fukuda, Nicolas Barnich, Nobuhiko Kamada
Nature microbiology Vol. 5 No. 1 p. 116-125 2020年1月 研究論文（学術雑誌）
Flagellin-mediated activation of IL-33-ST2 signaling by a pathobiont promotes intestinal fibrosis.
Jin Imai, Sho Kitamoto, Kohei Sugihara, Hiroko Nagao-Kitamoto, Atsushi Hayashi, Tina L Morhardt, Peter Kuffa, Peter D R Higgins, Nicolas Barnich, Nobuhiko Kamada
Mucosal immunology Vol. 12 No. 3 p. 632-643 2019年5月 研究論文（学術雑誌）
Functional Characterization of Inflammatory Bowel Disease-Associated Gut Dysbiosis in Gnotobiotic Mice.
Hiroko Nagao-Kitamoto, Andrew B Shreiner, Merritt G Gillilland 3rd, Sho Kitamoto, Chiharu Ishii, Akiyoshi Hirayama, Peter Kuffa, Mohamad El-Zaatari, Helmut Grasberger, Anna M Seekatz, Peter D R Higgins, Vincent B Young, Shinji Fukuda, John Y Kao, Nobuhiko Kamada
Cellular and molecular gastroenterology and hepatology Vol. 2 No. 4 p. 468-481 2016年7月 研究論文（学術雑誌）
Intestinal macrophages arising from CCR2(+) monocytes control pathogen infection by activating innate lymphoid cells.
Sang-Uk Seo, Peter Kuffa, Sho Kitamoto, Hiroko Nagao-Kitamoto, Jenna Rousseau, Yun-Gi Kim, Gabriel Núñez, Nobuhiko Kamada
Nature communications Vol. 6 p. 8010-8010 2015年8月13日 研究論文（学術雑誌）
Humoral Immunity in the Gut Selectively Targets Phenotypically Virulent Attaching-and-Effacing Bacteria for Intraluminal Elimination.
Nobuhiko Kamada, Kei Sakamoto, Sang-Uk Seo, Melody Y Zeng, Yun-Gi Kim, Marilia Cascalho, Bruce A Vallance, José L Puente, Gabriel Núñez
Cell host & microbe Vol. 17 No. 5 p. 617-27 2015年5月13日 研究論文（学術雑誌）
Control of pathogens and pathobionts by the gut microbiota.
Nobuhiko Kamada, Grace Y Chen, Naohiro Inohara, Gabriel Núñez
Nature immunology Vol. 14 No. 7 p. 685-90 2013年7月 研究論文（学術雑誌）
Role of the gut microbiota in immunity and inflammatory disease.
Nobuhiko Kamada, Sang-Uk Seo, Grace Y Chen, Gabriel Núñez
Nature reviews. Immunology Vol. 13 No. 5 p. 321-35 2013年5月 研究論文（学術雑誌）
Regulated virulence controls the ability of a pathogen to compete with the gut microbiota.
Nobuhiko Kamada, Yun-Gi Kim, Ho Pan Sham, Bruce A Vallance, José L Puente, Eric C Martens, Gabriel Núñez
Science (New York, N.Y.) Vol. 336 No. 6086 p. 1325-9 2012年6月8日 研究論文（学術雑誌）
NLRC4-driven production of IL-1β discriminates between pathogenic and commensal bacteria and promotes host intestinal defense.
Luigi Franchi, Nobuhiko Kamada, Yuumi Nakamura, Aaron Burberry, Peter Kuffa, Shiho Suzuki, Michael H Shaw, Yun-Gi Kim, Gabriel Núñez
Nature immunology Vol. 13 No. 5 p. 449-56 2012年5月 研究論文（学術雑誌）
Unique CD14 intestinal macrophages contribute to the pathogenesis of Crohn disease via IL-23/IFN-gamma axis.
Nobuhiko Kamada, Tadakazu Hisamatsu, Susumu Okamoto, Hiroshi Chinen, Taku Kobayashi, Toshiro Sato, Atsushi Sakuraba, Mina T Kitazume, Akira Sugita, Kazutaka Koganei, Kiyoko S Akagawa, Toshifumi Hibi
The Journal of clinical investigation Vol. 118 No. 6 p. 2269-80 2008年6月 研究論文（学術雑誌）
A meta-analysis of the gut microbiome in inflammatory bowel disease patients identifies disease-associated small molecules.
Moamen M Elmassry, Kohei Sugihara, Pranatchareeya Chankhamjon, Yeji Kim, Francine R Camacho, Shuo Wang, Yuki Sugimoto, Seema Chatterjee, Lea Ann Chen, Nobuhiko Kamada, Mohamed S Donia
Cell host & microbe Vol. 33 No. 2 p. 218-234 2025年2月12日 研究論文（学術雑誌）
Inulin-gel-based oral immunotherapy remodels the small intestinal microbiome and suppresses food allergy.
Kai Han, Fang Xie, Olamide Animasahun, Minal Nenwani, Sho Kitamoto, Yeji Kim, May Thazin Phoo, Jin Xu, Fulei Wuchu, Kehinde Omoloja, Abhinav Achreja, Srinadh Choppara, Zhaoheng Li, Wang Gong, Young Seok Cho, Hannah Dobson, Jinsung Ahn, Xingwu Zhou, Xuehui Huang, Xinran An, Alexander Kim, Yao Xu, Qi Wu, Soo-Hong Lee, Jessica J O'Konek, Yuying Xie, Yu Leo Lei, Nobuhiko Kamada, Deepak Nagrath, James J Moon
Nature materials 2024年7月8日 研究論文（学術雑誌）
Metabolic network of the gut microbiota in inflammatory bowel disease.
Kohei Sugihara, Nobuhiko Kamada
Inflammation and regeneration Vol. 44 No. 1 p. 11-11 2024年3月5日 研究論文（学術雑誌）
Oral pathobiont Klebsiella chaperon usher pili provide site-specific adaptation for the inflamed gut mucosa.
Yijie Guo, Sho Kitamoto, Gustavo Caballero-Flores, Yeji Kim, Daisuke Watanabe, Kohei Sugihara, Gabriel Núñez, Christopher J Alteri, Naohiro Inohara, Nobuhiko Kamada
Gut microbes Vol. 16 No. 1 p. 2333463-2333463 2024年 研究論文（学術雑誌）
The oral-gut axis: a missing piece in the IBD puzzle.
Sho Kitamoto, Nobuhiko Kamada
Inflammation and regeneration Vol. 43 No. 1 p. 54-54 2023年11月6日 研究論文（学術雑誌）
クローン病関連大腸菌のcyclic-di-AMPシグナルの亢進
田中 里佳, 津川 仁, 今井 仁, 鎌田 信彦, 穂積 勝人
日本細菌学雑誌 Vol. 78 No. 1 p. 76-76 2023年2月
出版者・発行元：日本細菌学会クローン病の腸管線維化に影響を与える病原性共生菌の同定とそのメカニズム
今井 仁, 鈴木 秀和, 西崎 泰弘, 鎌田 信彦
日本細菌学雑誌 Vol. 78 No. 1 p. 141-141 2023年2月
出版者・発行元：日本細菌学会Adherent-invasive E. coli - induced specific IgA limits pathobiont localization to the epithelial niche in the gut.
Rika Tanaka, Jin Imai, Hitoshi Tsugawa, Karl Bil Eap, Masaki Yazawa, Motoki Kaneko, Masashi Ohno, Kohei Sugihara, Sho Kitamoto, Hiroko Nagao-Kitamoto, Nicolas Barnich, Masashi Matsushima, Takayoshi Suzuki, Tatehiro Kagawa, Yasuhiro Nishizaki, Hidekazu Suzuki, Nobuhiko Kamada, Katsuto Hozumi
Frontiers in microbiology Vol. 14 p. 1031997-1031997 2023年 研究論文（学術雑誌）
Untangling the oral-gut axis in the pathogenesis of intestinal inflammation.
Sho Kitamoto, Nobuhiko Kamada
International immunology Vol. 34 No. 9 p. 485-490 2022年9月6日 研究論文（学術雑誌）
Inflammatory bowel disease and carcinogenesis
Hiroko Nagao-Kitamoto, Sho Kitamoto, Nobuhiko Kamada
Cancer and Metastasis Reviews 2022年4月13日 研究論文（学術雑誌）
出版者・発行元：Springer Science and Business Media LLC
Periodontal connection with intestinal inflammation: Microbiological and immunological mechanisms.
Sho Kitamoto, Nobuhiko Kamada
Periodontology 2000 2022年3月4日 研究論文（学術雑誌）
Interaction between the inflammasome and commensal microorganisms in gastrointestinal health and disease.
Daisuke Watanabe, Yijie Guo, Nobuhiko Kamada
EMBO molecular medicine 2021年10月27日 研究論文（学術雑誌）
Oral nanomedicine for modulating immunity, intestinal barrier functions, and gut microbiome.
Yonghyun Lee, Nobuhiko Kamada, James J Moon
Advanced drug delivery reviews p. 114021-114021 2021年10月25日 研究論文（学術雑誌）
TNFRSF13B polymorphisms counter microbial adaptation to enteric IgA.
Jeffrey L Platt, Mayara Garcia de Mattos Barbosa, Daniel Huynh, Adam R Lefferts, Juhi Katta, Cyra Kharas, Peter Freddolino, Christine M Bassis, Christiane Wobus, Raif Geha, Richard Bram, Gabriel Nunez, Nobuhiko Kamada, Marilia Cascalho
JCI insight Vol. 6 No. 14 2021年7月22日 研究論文（学術雑誌）
The pathogenic oral-gut-liver axis: new understandings and clinical implications.
Jin Imai, Sho Kitamoto, Nobuhiko Kamada
Expert review of clinical immunology Vol. 17 No. 7 p. 727-736 2021年7月 研究論文（学術雑誌）
Generation of systemic antitumour immunity via the in situ modulation of the gut microbiome by an orally administered inulin gel.
Kai Han, Jutaek Nam, Jin Xu, Xiaoqi Sun, Xuehui Huang, Olamide Animasahun, Abhinav Achreja, Jin Heon Jeon, Benjamin Pursley, Nobuhiko Kamada, Grace Y Chen, Deepak Nagrath, James J Moon
Nature biomedical engineering 2021年6月24日 研究論文（学術雑誌）
DUOX2 variants associate with preclinical disturbances in microbiota-immune homeostasis and increased inflammatory bowel disease risk.
Helmut Grasberger, Andrew T Magis, Elisa Sheng, Matthew P Conomos, Min Zhang, Lea S Garzotto, Guoqing Hou, Shrinivas Bishu, Hiroko Nagao-Kitamoto, Mohamad El-Zaatari, Sho Kitamoto, Nobuhiko Kamada, Ryan W Stidham, Yasutada Akiba, Jonathan Kaunitz, Yael Haberman, Subra Kugathasan, Lee A Denson, Gilbert S Omenn, John Y Kao
The Journal of clinical investigation Vol. 131 No. 9 2021年5月3日 研究論文（学術雑誌）
Diet-Microbiota Interactions in Inflammatory Bowel Disease.
Kohei Sugihara, Nobuhiko Kamada
Nutrients Vol. 13 No. 5 2021年5月1日 研究論文（学術雑誌）
Machine learning-assisted immune profiling stratifies peri-implantitis patients with unique microbial colonization and clinical outcomes.
Chin-Wei Wang, Yuning Hao, Riccardo Di Gianfilippo, James Sugai, Jiaqian Li, Wang Gong, Kenneth S Kornman, Hom-Lay Wang, Nobuhiko Kamada, Yuying Xie, William V Giannobile, Yu Leo Lei
Theranostics Vol. 11 No. 14 p. 6703-6716 2021年 研究論文（学術雑誌）
Microbial adaptation to the healthy and inflamed gut environments.
Yijie Guo, Sho Kitamoto, Nobuhiko Kamada
Gut microbes Vol. 12 No. 1 p. 1857505-1857505 2020年11月9日 研究論文（学術雑誌）
Lipopolysaccharide O structure of adherent and invasive Escherichia coli regulates intestinal inflammation via complement C3.
Masashi Ohno, Mizuho Hasegawa, Atsushi Hayashi, Gustavo Caballero-Flores, Christopher J Alteri, Trevor D Lawley, Nobuhiko Kamada, Gabriel Núñez, Naohiro Inohara
PLoS pathogens Vol. 16 No. 10 2020年10月 研究論文（学術雑誌）
The Bacterial Connection between the Oral Cavity and the Gut Diseases
S. Kitamoto, H. Nagao-Kitamoto, R. Hein, T.M. Schmidt, N. Kamada
Journal of Dental Research Vol. 99 No. 9 p. 1021-1029 2020年8月 研究論文（学術雑誌）
出版者・発行元：SAGE Publications
Aim2-mediated/IFN-β-independent regulation of gastric metaplastic lesions via CD8+ T cells.
Mohamad El-Zaatari, Shrinivas Bishu, Min Zhang, Helmut Grasberger, Guoqing Hou, Henry Haley, Brock Humphries, Li-Jyun Syu, Andrzej A Dlugosz, Kathy Luker, Gary D Luker, Kathryn Eaton, Nobuhiko Kamada, Marilia Cascalho, John Y Kao
JCI insight Vol. 5 No. 5 2020年3月12日 研究論文（学術雑誌）
Hyaluronic acid-bilirubin nanomedicine for targeted modulation of dysregulated intestinal barrier, microbiome and immune responses in colitis.
Yonghyun Lee, Kohei Sugihara, Merritt G Gillilland 3rd, Sangyong Jon, Nobuhiko Kamada, James J Moon
Nature materials Vol. 19 No. 1 p. 118-126 2020年1月 研究論文（学術雑誌）
CD4+ Tissue-resident Memory T Cells Expand and Are a Major Source of Mucosal Tumour Necrosis Factor α in Active Crohn's Disease.
Shrinivas Bishu, Mohammed El Zaatari, Atsushi Hayashi, Guoqing Hou, Nicole Bowers, Jami Kinnucan, Beth Manoogian, Michelle Muza-Moons, Min Zhang, Helmut Grasberger, Charlie Bourque, Weiping Zou, Peter D R Higgins, Jason R Spence, Ryan W Stidham, Nobuhiko Kamada, John Y Kao
Journal of Crohn's & colitis Vol. 13 No. 7 p. 905-915 2019年7月25日 研究論文（学術雑誌）
The regenerating family member 3 β instigates IL-17A-mediated neutrophil recruitment downstream of NOD1/2 signalling for controlling colonisation resistance independently of microbiota community structure.
Nadine Waldschmitt, Sho Kitamoto, Thomas Secher, Vassiliki Zacharioudaki, Olivier Boulard, Emilie Floquet, Myriam Delacre, Bruno Lamas, Hang-Phuong Pham, Adrien Six, Mathias L Richard, Jean-Charles Dagorn, Gérard Eberl, Philippe Langella, Jean-Marc Chatel, Bernhard Ryffel, Juan Lucio Iovanna, Lionel F Poulin, Harry Sokol, Nobuhiko Kamada, Mathias Chamaillard
Gut Vol. 68 No. 7 p. 1190-1199 2019年7月 研究論文（学術雑誌）
Fecal microbiota transplantation prevents Candida albicans from colonizing the gastrointestinal tract.
Kenzo Matsuo, Akira Haku, Beibei Bi, Hiroki Takahashi, Nobuhiko Kamada, Takashi Yaguchi, Shinobu Saijo, Mitsutoshi Yoneyama, Yoshiyuki Goto
Microbiology and immunology Vol. 63 No. 5 p. 155-163 2019年5月 研究論文（学術雑誌）
Gut pathobionts underlie intestinal barrier dysfunction and liver T helper 17 cell immune response in primary sclerosing cholangitis.
Nobuhiro Nakamoto, Nobuo Sasaki, Ryo Aoki, Kentaro Miyamoto, Wataru Suda, Toshiaki Teratani, Takahiro Suzuki, Yuzo Koda, Po-Sung Chu, Nobuhito Taniki, Akihiro Yamaguchi, Mitsuhiro Kanamori, Nobuhiko Kamada, Masahira Hattori, Hiroshi Ashida, Michiie Sakamoto, Koji Atarashi, Seiko Narushima, Akihiko Yoshimura, Kenya Honda, Toshiro Sato, Takanori Kanai
Nature microbiology Vol. 4 No. 3 p. 492-503 2019年3月 研究論文（学術雑誌）
IL-10 produced by macrophages regulates epithelial integrity in the small intestine.
Tina L Morhardt, Atsushi Hayashi, Takanori Ochi, Miguel Quirós, Sho Kitamoto, Hiroko Nagao-Kitamoto, Peter Kuffa, Koji Atarashi, Kenya Honda, John Y Kao, Asma Nusrat, Nobuhiko Kamada
Scientific reports Vol. 9 No. 1 p. 1223-1223 2019年2月4日 研究論文（学術雑誌）
Microbiota-Derived Lactate Accelerates Intestinal Stem-Cell-Mediated Epithelial Development.
Yong-Soo Lee, Tae-Young Kim, Yeji Kim, Su-Hyun Lee, Seungil Kim, Sung Wan Kang, Jin-Young Yang, In-Jeoung Baek, Young Hoon Sung, Yun-Yong Park, Sung Wook Hwang, Eunju O, Kwang Soon Kim, Siqing Liu, Nobuhiko Kamada, Nan Gao, Mi-Na Kweon
Cell host & microbe Vol. 24 No. 6 p. 833-846 2018年12月12日 研究論文（学術雑誌）
Su1944 - Intestinal Dysbiosis Induces Systemic Dysregulation of Biotin Metabolism, Resulting in Extraintestinal Manifestation
Yohei Mikami, Atsushi Hayashi, Kentaro Miyamoto, Nobuhiko Kamada, Toshiro Sato, Shinta Mizuno, Makoto Naganuma, Toshiaki Teratani, Ryo Aoki, Shinji Fukuda, Wataru Suda, Masahira Hattori, Masayuki Amagai, Manabu Ohyama, Takanori Kanai
Gastroenterology Vol. 154 No. 6 p. S-642 2018年5月 研究論文（学術雑誌）
出版者・発行元：Elsevier BV
Regional control of regulatory immune cells in the intestine.
Tina L Morhardt, Atsushi Hayashi, John Y Kao, Nobuhiko Kamada
Current pathobiology reports Vol. 6 No. 1 p. 29-34 2018年3月 研究論文（学術雑誌）
Bile acid metabolism regulated by the gut microbiota promotes non-alcoholic steatohepatitis-associated hepatocellular carcinoma in mice.
Shoji Yamada, Yoko Takashina, Mitsuhiro Watanabe, Ryogo Nagamine, Yoshimasa Saito, Nobuhiko Kamada, Hidetsugu Saito
Oncotarget Vol. 9 No. 11 p. 9925-9939 2018年2月9日 研究論文（学術雑誌）
Expression and regulation of proton-coupled oligopeptide transporters in colonic tissue and immune cells of mice.
Yuqing Wang, Yongjun Hu, Ping Li, Yayun Weng, Nobuhiko Kamada, Huidi Jiang, David E Smith
Biochemical pharmacology Vol. 148 p. 163-173 2018年2月 研究論文（学術雑誌）
Indoleamine 2,3-Dioxygenase 1, Increased in Human Gastric Pre-Neoplasia, Promotes Inflammation and Metaplasia in Mice and Is Associated With Type II Hypersensitivity/Autoimmunity.
Mohamad El-Zaatari, Adam J Bass, Reanne Bowlby, Min Zhang, Li-Jyun Syu, Yitian Yang, Helmut Grasberger, Andrew Shreiner, Bei Tan, Shrinivas Bishu, Wai K Leung, Andrea Todisco, Nobuhiko Kamada, Marilia Cascalho, Andrzej A Dlugosz, John Y Kao
Gastroenterology Vol. 154 No. 1 p. 140-153 2018年1月 研究論文（学術雑誌）
The Role of Dietary Nutrients in Inflammatory Bowel Disease.
Kohei Sugihara, Tina L Morhardt, Nobuhiko Kamada
Frontiers in immunology Vol. 9 p. 3183-3183 2018年 研究論文（学術雑誌）
Gut microbiota-mediated generation of saturated fatty acids elicits inflammation in the liver in murine high-fat diet-induced steatohepatitis.
Shoji Yamada, Nobuhiko Kamada, Takeru Amiya, Nobuhiro Nakamoto, Toshiaki Nakaoka, Masaki Kimura, Yoshimasa Saito, Chieko Ejima, Takanori Kanai, Hidetsugu Saito
BMC gastroenterology Vol. 17 No. 1 p. 136-136 2017年11月29日 研究論文（学術雑誌）
Quantitative proteomics identifies STEAP4 as a critical regulator of mitochondrial dysfunction linking inflammation and colon cancer.
Xiang Xue, Bryce X Bredell, Erik R Anderson, Angelical Martin, Christopher Mays, Hiroko Nagao-Kitamoto, Sha Huang, Balázs Győrffy, Joel K Greenson, Karin Hardiman, Jason R Spence, Nobuhiko Kamada, Yatrik M Shah
Proceedings of the National Academy of Sciences of the United States of America Vol. 114 No. 45 2017年11月7日 研究論文（学術雑誌）
Commensal Lactobacillus Controls Immune Tolerance during Acute Liver Injury in Mice.
Nobuhiro Nakamoto, Takeru Amiya, Ryo Aoki, Nobuhito Taniki, Yuzo Koda, Kentaro Miyamoto, Toshiaki Teratani, Takahiro Suzuki, Sayako Chiba, Po-Sung Chu, Atsushi Hayashi, Akihiro Yamaguchi, Shunsuke Shiba, Rei Miyake, Tadashi Katayama, Wataru Suda, Yohei Mikami, Nobuhiko Kamada, Hirotoshi Ebinuma, Hidetsugu Saito, Masahira Hattori, Takanori Kanai
Cell reports Vol. 21 No. 5 p. 1215-1226 2017年10月31日 研究論文（学術雑誌）
Mesenchymal Cell-Specific MyD88 Signaling Promotes Systemic Dissemination of Salmonella Typhimurium via Inflammatory Monocytes.
Donghyun Kim, Sang-Uk Seo, Melody Y Zeng, Wan-Uk Kim, Nobuhiko Kamada, Naohiro Inohara, Gabriel Núñez
Journal of immunology (Baltimore, Md. : 1950) Vol. 199 No. 4 p. 1362-1371 2017年8月15日 研究論文（学術雑誌）
Intestinal Dysbiosis and Biotin Deprivation Induce Alopecia through Overgrowth of Lactobacillus murinus in Mice.
Atsushi Hayashi, Yohei Mikami, Kentaro Miyamoto, Nobuhiko Kamada, Toshiro Sato, Shinta Mizuno, Makoto Naganuma, Toshiaki Teratani, Ryo Aoki, Shinji Fukuda, Wataru Suda, Masahira Hattori, Masayuki Amagai, Manabu Ohyama, Takanori Kanai
Cell reports Vol. 20 No. 7 p. 1513-1524 2017年8月15日 研究論文（学術雑誌）
Host-microbial Cross-talk in Inflammatory Bowel Disease.
Hiroko Nagao-Kitamoto, Nobuhiko Kamada
Immune network Vol. 17 No. 1 p. 1-12 2017年2月 研究論文（学術雑誌）
IL-22 Controls Iron-Dependent Nutritional Immunity Against Systemic Bacterial Infections.
Kei Sakamoto, Yun-Gi Kim, Hideki Hara, Nobuhiko Kamada, Gustavo Caballero-Flores, Emanuela Tolosano, Miguel P Soares, José L Puente, Naohiro Inohara, Gabriel Núñez
Science immunology Vol. 2 No. 8 2017年2月 研究論文（学術雑誌）
A Dietary Fiber-Deprived Gut Microbiota Degrades the Colonic Mucus Barrier and Enhances Pathogen Susceptibility.
Mahesh S Desai, Anna M Seekatz, Nicole M Koropatkin, Nobuhiko Kamada, Christina A Hickey, Mathis Wolter, Nicholas A Pudlo, Sho Kitamoto, Nicolas Terrapon, Arnaud Muller, Vincent B Young, Bernard Henrissat, Paul Wilmes, Thaddeus S Stappenbeck, Gabriel Núñez, Eric C Martens
Cell Vol. 167 No. 5 p. 1339-1353 2016年11月17日 研究論文（学術雑誌）
The Innate Immune System: A Trigger for Many Chronic Inflammatory Intestinal Diseases.
Nobuhiko Kamada, Gerhard Rogler
Inflammatory intestinal diseases Vol. 1 No. 2 p. 70-77 2016年7月 研究論文（学術雑誌）
Diet-dependent, microbiota-independent regulation of IL-10-producing lamina propria macrophages in the small intestine.
Takanori Ochi, Yongjia Feng, Sho Kitamoto, Hiroko Nagao-Kitamoto, Peter Kuffa, Koji Atarashi, Kenya Honda, Daniel H Teitelbaum, Nobuhiko Kamada
Scientific reports Vol. 6 p. 27634-27634 2016年6月15日 研究論文（学術雑誌）
Nod2-mediated recognition of the microbiota is critical for mucosal adjuvant activity of cholera toxin.
Donghyun Kim, Yun-Gi Kim, Sang-Uk Seo, Dong-Jae Kim, Nobuhiko Kamada, Dave Prescott, Mathias Chamaillard, Dana J Philpott, Philip Rosenstiel, Naohiro Inohara, Gabriel Núñez
Nature medicine Vol. 22 No. 5 p. 524-30 2016年5月 研究論文（学術雑誌）
Pathogenic role of the gut microbiota in gastrointestinal diseases.
Hiroko Nagao-Kitamoto, Sho Kitamoto, Peter Kuffa, Nobuhiko Kamada
Intestinal research Vol. 14 No. 2 p. 127-38 2016年4月 研究論文（学術雑誌）
Regulation of virulence: the rise and fall of gastrointestinal pathogens.
Sho Kitamoto, Hiroko Nagao-Kitamoto, Peter Kuffa, Nobuhiko Kamada
Journal of gastroenterology Vol. 51 No. 3 p. 195-205 2016年3月 研究論文（学術雑誌）
Increased Expression of DUOX2 Is an Epithelial Response to Mucosal Dysbiosis Required for Immune Homeostasis in Mouse Intestine.
Helmut Grasberger, Jun Gao, Hiroko Nagao-Kitamoto, Sho Kitamoto, Min Zhang, Nobuhiko Kamada, Kathryn A Eaton, Mohamad El-Zaatari, Andrew B Shreiner, Juanita L Merchant, Chung Owyang, John Y Kao
Gastroenterology Vol. 149 No. 7 p. 1849-59 2015年12月 研究論文（学術雑誌）
Th17 Cell Induction by Adhesion of Microbes to Intestinal Epithelial Cells.
Koji Atarashi, Takeshi Tanoue, Minoru Ando, Nobuhiko Kamada, Yuji Nagano, Seiko Narushima, Wataru Suda, Akemi Imaoka, Hiromi Setoyama, Takashi Nagamori, Eiji Ishikawa, Tatsuichiro Shima, Taeko Hara, Shoichi Kado, Toshi Jinnohara, Hiroshi Ohno, Takashi Kondo, Kiminori Toyooka, Eiichiro Watanabe, Shin-Ichiro Yokoyama, Shunji Tokoro, Hiroshi Mori, Yurika Noguchi, Hidetoshi Morita, Ivaylo I Ivanov, Tsuyoshi Sugiyama, Gabriel Nuñez, J Gray Camp, Masahira Hattori, Yoshinori Umesaki, Kenya Honda
Cell Vol. 163 No. 2 p. 367-80 2015年10月8日 研究論文（学術雑誌）
Distinct Commensals Induce Interleukin-1β via NLRP3 Inflammasome in Inflammatory Monocytes to Promote Intestinal Inflammation in Response to Injury.
Sang-Uk Seo, Nobuhiko Kamada, Raúl Muñoz-Planillo, Yun-Gi Kim, Donghyun Kim, Yukiko Koizumi, Mizuho Hasegawa, Stephanie D Himpsl, Hilary P Browne, Trevor D Lawley, Harry L T Mobley, Naohiro Inohara, Gabriel Núñez
Immunity Vol. 42 No. 4 p. 744-55 2015年4月21日 研究論文（学術雑誌）
TACI deficiency enhances antibody avidity and clearance of an intestinal pathogen.
Shoichiro Tsuji, Lucas Stein, Nobuhiko Kamada, Gabriel Nuñez, Richard Bram, Bruce A Vallance, Ana E Sousa, Jeffrey L Platt, Marilia Cascalho
The Journal of clinical investigation Vol. 124 No. 11 p. 4857-66 2014年11月 研究論文（学術雑誌）
Interleukin-22 regulates the complement system to promote resistance against pathobionts after pathogen-induced intestinal damage.
Mizuho Hasegawa, Shoko Yada, Meng Zhen Liu, Nobuhiko Kamada, Raúl Muñoz-Planillo, Nhu Do, Gabriel Núñez, Naohiro Inohara
Immunity Vol. 41 No. 4 p. 620-32 2014年10月16日 研究論文（学術雑誌）
Cross-talk between RORγt+ innate lymphoid cells and intestinal macrophages induces mucosal IL-22 production in Crohn's disease.
Shinta Mizuno, Yohei Mikami, Nobuhiko Kamada, Tango Handa, Atsushi Hayashi, Toshiro Sato, Katsuyoshi Matsuoka, Mami Matano, Yuki Ohta, Akira Sugita, Kazutaka Koganei, Rikisaburo Sahara, Masakazu Takazoe, Tadakazu Hisamatsu, Takanori Kanai
Inflammatory bowel diseases Vol. 20 No. 8 p. 1426-34 2014年8月 研究論文（学術雑誌）
Tryptophan catabolism restricts IFN-γ-expressing neutrophils and Clostridium difficile immunopathology.
Mohamad El-Zaatari, Yu-Ming Chang, Min Zhang, Matthew Franz, Andrew Shreiner, Andrew J McDermott, Koenraad F van der Sluijs, René Lutter, Helmut Grasberger, Nobuhiko Kamada, Vincent B Young, Gary B Huffnagle, John Y Kao
Journal of immunology (Baltimore, Md. : 1950) Vol. 193 No. 2 p. 807-16 2014年7月15日 研究論文（学術雑誌）
Regulation of the immune system by the resident intestinal bacteria.
Nobuhiko Kamada, Gabriel Núñez
Gastroenterology Vol. 146 No. 6 p. 1477-88 2014年5月 研究論文（学術雑誌）
Macrophages and dendritic cells emerge in the liver during intestinal inflammation and predispose the liver to inflammation.
Yohei Mikami, Shinta Mizuno, Nobuhiro Nakamoto, Atsushi Hayashi, Tomohisa Sujino, Toshiro Sato, Nobuhiko Kamada, Katsuyoshi Matsuoka, Tadakazu Hisamatsu, Hirotoshi Ebinuma, Toshifumi Hibi, Akihiko Yoshimura, Takanori Kanai
PloS one Vol. 9 No. 1 2014年 研究論文（学術雑誌）
The tuning of the gut nervous system by commensal microbiota.
Nobuhiko Kamada, John Y Kao
Gastroenterology Vol. 145 No. 6 p. 1193-6 2013年12月
Clinical strategies for the blockade of IL-18 in inflammatory bowel diseases.
Takanori Kanai, Nobuhiko Kamada, Tadakazu Hisamatsu
Current drug targets Vol. 14 No. 12 p. 1392-9 2013年11月 研究論文（学術雑誌）
Multiple effects of dendritic cell depletion on murine norovirus infection.
Michael D Elftman, Mariam B Gonzalez-Hernandez, Nobuhiko Kamada, Cheryl Perkins, Kenneth S Henderson, Gabriel Núñez, Christiane E Wobus
The Journal of general virology Vol. 94 No. Pt 8 p. 1761-1768 2013年8月 研究論文（学術雑誌）
Establishment of novel prediction system of intestinal absorption in humans using human intestinal tissues.
Masateru Miyake, Hajime Toguchi, Toru Nishibayashi, Kazutaka Higaki, Akira Sugita, Kazutaka Koganei, Nobuhiko Kamada, Mina T Kitazume, Tadakazu Hisamatsu, Toshiro Sato, Susumu Okamoto, Takanori Kanai, Toshifumi Hibi
Journal of pharmaceutical sciences Vol. 102 No. 8 p. 2564-71 2013年8月 研究論文（学術雑誌）
A single strain of Clostridium butyricum induces intestinal IL-10-producing macrophages to suppress acute experimental colitis in mice.
Atsushi Hayashi, Toshiro Sato, Nobuhiko Kamada, Yohei Mikami, Katsuyoshi Matsuoka, Tadakazu Hisamatsu, Toshifumi Hibi, Axel Roers, Hideo Yagita, Toshiaki Ohteki, Akihiko Yoshimura, Takanori Kanai
Cell host & microbe Vol. 13 No. 6 p. 711-22 2013年6月12日 研究論文（学術雑誌）
Activated hepatic stellate cells mediate the differentiation of macrophages.
Jonathan Chang, Tadakazu Hisamatsu, Katsuyoshi Shimamura, Kazuaki Yoneno, Masayuki Adachi, Hiroshi Naruse, Toru Igarashi, Hajime Higuchi, Katsuyoshi Matsuoka, Mina T Kitazume, Setsu Ando, Nobuhiko Kamada, Takanori Kanai, Toshifumi Hibi
Hepatology research : the official journal of the Japan Society of Hepatology Vol. 43 No. 6 p. 658-69 2013年6月 研究論文（学術雑誌）
Tu1976 Clostridium Butyricum Regulates IL-10 Production in Normal and Inflammatory Conditions Through Different Target Cells
Atsushi Hayashi, Takanori Kanai, Toshiro Sato, Yohei Mikami, Katsuyoshi Matsuoka, Tadakazu Hisamatsu, Akihiko Yoshimura, Nobuhiko Kamada, Hideo Yagita, Toshifumi Hibi
Gastroenterology Vol. 144 No. 5 p. S-895 2013年5月 研究論文（学術雑誌）
出版者・発行元：Elsevier BV
TGR5 signalling inhibits the production of pro-inflammatory cytokines by in vitro differentiated inflammatory and intestinal macrophages in Crohn's disease.
Kazuaki Yoneno, Tadakazu Hisamatsu, Katsuyoshi Shimamura, Nobuhiko Kamada, Riko Ichikawa, Mina T Kitazume, Maiko Mori, Michihide Uo, Yuka Namikawa, Katsuyoshi Matsuoka, Toshiro Sato, Kazutaka Koganei, Akira Sugita, Takanori Kanai, Toshifumi Hibi
Immunology Vol. 139 No. 1 p. 19-29 2013年5月 研究論文（学術雑誌）
Role of the gut microbiota in the development and function of lymphoid cells.
Nobuhiko Kamada, Gabriel Núñez
Journal of immunology (Baltimore, Md. : 1950) Vol. 190 No. 4 p. 1389-95 2013年2月15日 研究論文（学術雑誌）
Protective role of commensals against Clostridium difficile infection via an IL-1β-mediated positive-feedback loop.
Mizuho Hasegawa, Nobuhiko Kamada, Yizu Jiao, Meng Zhen Liu, Gabriel Núñez, Naohiro Inohara
Journal of immunology (Baltimore, Md. : 1950) Vol. 189 No. 6 p. 3085-91 2012年9月15日 研究論文（学術雑誌）
A complex microworld in the gut: Harnessing pathogen-commensal relations.
Nobuhiko Kamada, Grace Chen, Gabriel Núñez
Nature medicine Vol. 18 No. 8 p. 1190-1 2012年8月 研究論文（学術雑誌）
Bile acids induce monocyte differentiation toward interleukin-12 hypo-producing dendritic cells via a TGR5-dependent pathway.
Riko Ichikawa, Tetsuro Takayama, Kazuaki Yoneno, Nobuhiko Kamada, Mina T Kitazume, Hajime Higuchi, Katsuyoshi Matsuoka, Mitsuhiro Watanabe, Hiroshi Itoh, Takanori Kanai, Tadakazu Hisamatsu, Toshifumi Hibi
Immunology Vol. 136 No. 2 p. 153-62 2012年6月 研究論文（学術雑誌）
Mo1783 New Immunosuppressive System by Myeloid-Derived Suppressor Cells in the Lamina Propria of Ulcerative Colitis Patients
Yohei Mikami, Takanori Kanai, Shinta Mizuno, Tomohisa Sujino, Tango Handa, Atsuhiro Matsumoto, Toshiro Sato, Nobuhiko Kamada, Katsuyoshi Matsuoka, Tadakazu Hisamatsu, Akira Sonoda, Masakazu Takazoe, Rikisaburo Sahara, Kazutaka Koganei, Akira Sugita, Toshifumi Hibi
Gastroenterology Vol. 142 No. 5 p. S-684 2012年5月 研究論文（学術雑誌）
出版者・発行元：Elsevier BV
Microbiota-induced IL-1β, but not IL-6, is critical for the development of steady-state TH17 cells in the intestine.
Michael H Shaw, Nobuhiko Kamada, Yun-Gi Kim, Gabriel Núñez
The Journal of experimental medicine Vol. 209 No. 2 p. 251-8 2012年2月13日 研究論文（学術雑誌）
Both exogenous commensal and endogenous self antigens stimulate T cell proliferation under lymphopenic conditions.
Jeong-su Do, Gilles Foucras, Nobuhiko Kamada, Austin F Schenk, Michael Shaw, Gabriel Nuñez, William E Paul, Booki Min
Cellular immunology Vol. 272 No. 2 p. 117-23 2012年 研究論文（学術雑誌）
The Nod2 sensor promotes intestinal pathogen eradication via the chemokine CCL2-dependent recruitment of inflammatory monocytes.
Yun-Gi Kim, Nobuhiko Kamada, Michael H Shaw, Neil Warner, Grace Y Chen, Luigi Franchi, Gabriel Núñez
Immunity Vol. 34 No. 5 p. 769-80 2011年5月27日 研究論文（学術雑誌）
NFIL3 is a regulator of IL-12 p40 in macrophages and mucosal immunity.
Taku Kobayashi, Katsuyoshi Matsuoka, Shehzad Z Sheikh, Houda Z Elloumi, Nobuhiko Kamada, Tadakazu Hisamatsu, Jonathan J Hansen, Kevin R Doty, Scott D Pope, Stephen T Smale, Toshifumi Hibi, Paul B Rothman, Masaki Kashiwada, Scott E Plevy
Journal of immunology (Baltimore, Md. : 1950) Vol. 186 No. 8 p. 4649-55 2011年4月15日 研究論文（学術雑誌）
Nucleotide-binding oligomerization domain 1 mediates recognition of Clostridium difficile and induces neutrophil recruitment and protection against the pathogen.
Mizuho Hasegawa, Takashi Yamazaki, Nobuhiko Kamada, Kazuki Tawaratsumida, Yun-Gi Kim, Gabriel Núñez, Naohiro Inohara
Journal of immunology (Baltimore, Md. : 1950) Vol. 186 No. 8 p. 4872-80 2011年4月15日 研究論文（学術雑誌）
The ever-expanding function of NOD2: autophagy, viral recognition, and T cell activation.
Michael H Shaw, Nobuhiko Kamada, Neil Warner, Yun-Gi Kim, Gabriel Nuñez
Trends in immunology Vol. 32 No. 2 p. 73-9 2011年2月 研究論文（学術雑誌）
Imbalance of NKp44(+)NKp46(-) and NKp44(-)NKp46(+) natural killer cells in the intestinal mucosa of patients with Crohn's disease.
Tetsuro Takayama, Nobuhiko Kamada, Hiroshi Chinen, Susumu Okamoto, Mina T Kitazume, Jonathan Chang, Yumi Matuzaki, Sadafumi Suzuki, Akira Sugita, Kazutaka Koganei, Tadakazu Hisamatsu, Takanori Kanai, Toshifumi Hibi
Gastroenterology Vol. 139 No. 3 p. 882-92 2010年9月 研究論文（学術雑誌）
Competition between colitogenic Th1 and Th17 cells contributes to the amelioration of colitis.
Yohei Mikami, Takanori Kanai, Tomohisa Sujino, Yuichi Ono, Atsushi Hayashi, Akira Okazawa, Nobuhiko Kamada, Katsuyoshi Matsuoka, Tadakazu Hisamatsu, Susumu Okamoto, Hiromasa Takaishi, Nagamu Inoue, Haruhiko Ogata, Toshifumi Hibi
European journal of immunology Vol. 40 No. 9 p. 2409-22 2010年9月 研究論文（学術雑誌）
TL1A produced by lamina propria macrophages induces Th1 and Th17 immune responses in cooperation with IL-23 in patients with Crohn's disease.
Nobuhiko Kamada, Tadakazu Hisamatsu, Haruki Honda, Taku Kobayashi, Hiroshi Chinen, Tetsuro Takayama, Mina T Kitazume, Susumu Okamoto, Kazutaka Koganei, Akira Sugita, Takanori Kanai, Toshifumi Hibi
Inflammatory bowel diseases Vol. 16 No. 4 p. 568-75 2010年4月 研究論文（学術雑誌）
Monocyte chemoattractant protein-1 contributes to gut homeostasis and intestinal inflammation by composition of IL-10-producing regulatory macrophage subset.
Yasuhiro Takada, Tadakazu Hisamatsu, Nobuhiko Kamada, Mina T Kitazume, Haruki Honda, Yosuke Oshima, Riko Saito, Tetsuro Takayama, Taku Kobayashi, Hiroshi Chinen, Yohei Mikami, Takanori Kanai, Susumu Okamoto, Toshifumi Hibi
Journal of immunology (Baltimore, Md. : 1950) Vol. 184 No. 5 p. 2671-6 2010年3月1日 研究論文（学術雑誌）
Th1/Th17 immune response is induced by mesenteric lymph node dendritic cells in Crohn's disease.
Atsushi Sakuraba, Toshiro Sato, Nobuhiko Kamada, Mina Kitazume, Akira Sugita, Toshifumi Hibi
Gastroenterology Vol. 137 No. 5 p. 1736-45 2009年11月 研究論文（学術雑誌）
Retinoic acid contributes to the induction of IL-12-hypoproducing dendritic cells.
Yasuyo Wada, Tadakazu Hisamatsu, Nobuhiko Kamada, Susumu Okamoto, Toshifumi Hibi
Inflammatory bowel diseases Vol. 15 No. 10 p. 1548-56 2009年10月 研究論文（学術雑誌）
Human CD14+ macrophages in intestinal lamina propria exhibit potent antigen-presenting ability.
Nobuhiko Kamada, Tadakazu Hisamatsu, Haruki Honda, Taku Kobayashi, Hiroshi Chinen, Mina Tokutake Kitazume, Tetsuro Takayama, Susumu Okamoto, Kazutaka Koganei, Akira Sugita, Takanori Kanai, Toshifumi Hibi
Journal of immunology (Baltimore, Md. : 1950) Vol. 183 No. 3 p. 1724-31 2009年8月1日 研究論文（学術雑誌）
Homeostatic (IL-7) and effector (IL-17) cytokines as distinct but complementary target for an optimal therapeutic strategy in inflammatory bowel disease.
Takanori Kanai, Yasuhiro Nemoto, Nobuhiko Kamada, Teruji Totsuka, Tadakazu Hisamatsu, Mamoru Watanabe, Toshifumi Hibi
Current opinion in gastroenterology Vol. 25 No. 4 p. 306-13 2009年7月 研究論文（学術雑誌）
[Pathogenic roles of intestinal macrophages in inflammatory bowel disease].
Nobuhiko Kamada, Toshifumi Hibi
Nihon yakurigaku zasshi. Folia pharmacologica Japonica Vol. 133 No. 4 p. 186-9 2009年4月 研究論文（学術雑誌）
Dietary histidine ameliorates murine colitis by inhibition of proinflammatory cytokine production from macrophages.
Ayatoshi Andou, Tadakazu Hisamatsu, Susumu Okamoto, Hiroshi Chinen, Nobuhiko Kamada, Taku Kobayashi, Masaki Hashimoto, Tomohisa Okutsu, Kazutaka Shimbo, Tomoko Takeda, Hideki Matsumoto, Atsushi Sato, Hiroshi Ohtsu, Manabu Suzuki, Toshifumi Hibi
Gastroenterology Vol. 136 No. 2 p. 564-74 2009年2月 研究論文（学術雑誌）
IL23 differentially regulates the Th1/Th17 balance in ulcerative colitis and Crohn's disease.
T Kobayashi, S Okamoto, T Hisamatsu, N Kamada, H Chinen, R Saito, M T Kitazume, A Nakazawa, A Sugita, K Koganei, K Isobe, T Hibi
Gut Vol. 57 No. 12 p. 1682-9 2008年12月 研究論文（学術雑誌）
Tetomilast suppressed production of proinflammatory cytokines from human monocytes and ameliorated chronic colitis in IL-10-deficient mice.
Hitoshi Ichikawa, Susumu Okamoto, Nobuhiko Kamada, Hisashi Nagamoto, Mina T Kitazume, Taku Kobayashi, Hiroshi Chinen, Tadakazu Hisamatsu, Toshifumi Hibi
Inflammatory bowel diseases Vol. 14 No. 11 p. 1483-90 2008年11月 研究論文（学術雑誌）
Imbalance in intestinal microflora constitution could be involved in the pathogenesis of inflammatory bowel disease.
Hiromasa Takaishi, Takahiro Matsuki, Atsushi Nakazawa, Toshihiko Takada, Shoichi Kado, Takashi Asahara, Nobuhiko Kamada, Atsushi Sakuraba, Tomoharu Yajima, Hajime Higuchi, Nagamu Inoue, Haruhiko Ogata, Yasushi Iwao, Koji Nomoto, Ryuichiro Tanaka, Toshifumi Hibi
International journal of medical microbiology : IJMM Vol. 298 No. 5-6 p. 463-72 2008年7月 研究論文（学術雑誌）
Nonpathogenic Escherichia coli strain Nissle 1917 inhibits signal transduction in intestinal epithelial cells.
Nobuhiko Kamada, Kenichi Maeda, Nagamu Inoue, Tadakazu Hisamatsu, Susumu Okamoto, Kyong Su Hong, Takaya Yamada, Noriaki Watanabe, Kanji Tsuchimoto, Haruhiko Ogata, Toshifumi Hibi
Infection and immunity Vol. 76 No. 1 p. 214-20 2008年1月 研究論文（学術雑誌）
Lamina propria c-kit+ immune precursors reside in human adult intestine and differentiate into natural killer cells.
Hiroshi Chinen, Katsuyoshi Matsuoka, Toshiro Sato, Nobuhiko Kamada, Susumu Okamoto, Tadakazu Hisamatsu, Taku Kobayashi, Hirotoshi Hasegawa, Akira Sugita, Fukunori Kinjo, Jiro Fujita, Toshifumi Hibi
Gastroenterology Vol. 133 No. 2 p. 559-73 2007年8月 研究論文（学術雑誌）
Exclusive increase of CX3CR1+CD28-CD4+ T cells in inflammatory bowel disease and their recruitment as intraepithelial lymphocytes.
Taku Kobayashi, Susumu Okamoto, Yuko Iwakami, Atsushi Nakazawa, Tadakazu Hisamatsu, Hiroshi Chinen, Nobuhiko Kamada, Toshio Imai, Hidemi Goto, Toshifumi Hibi
Inflammatory bowel diseases Vol. 13 No. 7 p. 837-46 2007年7月 研究論文（学術雑誌）
Inhibition of neutrophil elastase prevents the development of murine dextran sulfate sodium-induced colitis.
Yuichi Morohoshi, Katsuyoshi Matsuoka, Hiroshi Chinen, Nobuhiko Kamada, Toshiro Sato, Tadakazu Hisamatsu, Susumu Okamoto, Nagamu Inoue, Hiromasa Takaishi, Haruhiko Ogata, Yasushi Iwao, Toshifumi Hibi
Journal of gastroenterology Vol. 41 No. 4 p. 318-24 2006年4月 研究論文（学術雑誌）
Abnormally differentiated subsets of intestinal macrophage play a key role in Th1-dominant chronic colitis through excess production of IL-12 and IL-23 in response to bacteria.
Nobuhiko Kamada, Tadakazu Hisamatsu, Susumu Okamoto, Toshiro Sato, Katsuyoshi Matsuoka, Kumiko Arai, Takaaki Nakai, Akira Hasegawa, Nagamu Inoue, Noriaki Watanabe, Kiyoko S Akagawa, Toshifumi Hibi
Journal of immunology (Baltimore, Md. : 1950) Vol. 175 No. 10 p. 6900-8 2005年11月15日 研究論文（学術雑誌）
A novel apoptosis-inducing monoclonal antibody (anti-LHK) against a cell surface antigen on colon cancer cells.
Hidehiko Matsukawa, Takanori Kanai, Makoto Naganuma, Nobuhiko Kamada, Tadakazu Hisamatsu, Hiromasa Takaishi, Haruhiko Ogata, Makio Mukai, Hiromasa Ishii, Tsuneyo Mimori, Mamoru Watanabe, Toshifumi Hibi
Journal of gastroenterology Vol. 40 No. 10 p. 945-55 2005年10月 研究論文（学術雑誌）
Nonpathogenic Escherichia coli strain Nissle1917 prevents murine acute and chronic colitis.
Nobuhiko Kamada, Nagamu Inoue, Tadakazu Hisamatsu, Susumu Okamoto, Katsuyoshi Matsuoka, Toshiro Sato, Hiroshi Chinen, Kyong Su Hong, Takaya Yamada, Yumiko Suzuki, Tatsuo Suzuki, Noriaki Watanabe, Kanji Tsuchimoto, Toshifumi Hibi
Inflammatory bowel diseases Vol. 11 No. 5 p. 455-63 2005年5月 研究論文（学術雑誌）
消化管におけるtranslational research 歯周病合併クローン病における口腔内・腸内細菌叢解析と臨床経過
今井 仁, 鎌田 信彦, 北本 祥, 市川 仁志, 高橋 美穂, 白井 孝之, 穂積 勝人, 鈴木 秀和
日本消化管学会雑誌 Vol. 5 No. Suppl. p. 171-171 2021年1月
出版者・発行元：(一社)日本消化管学会歯周病合併クローン病における口腔内・腸内細菌叢解析と臨床経過
今井仁, 今井仁, 鎌田信彦, 北本祥, 市川仁志, 高橋美穂, 白井孝之, 穂積勝人, 鈴木秀和
日本消化管学会雑誌 Vol. 5 No. Supplement 2021年
接着性侵入性大腸菌(AIEC)はIL-33/ST2シグナルを介し腸管線維化を誘導する
今井 仁, 鈴木 孝良, 鎌田 信彦
日本消化器病学会雑誌 Vol. 116 No. 臨増大会 p. A796-A796 2019年11月
出版者・発行元：(一財)日本消化器病学会Competition Between Colitogenic T Helper 1 and 17 CD4(+) T Cells Contributes to the Amelioration of Colitis
Yohei Mikami, Takanori Kanai, Akira Okazawa, Yuichi Ono, Atsushi Hayashi, Tomohisa Sujino, Nobuhiko Kamada, Katsuyoshi Matsuoka, Tadakazu Hisamatsu, Susumu Okamoto, Hiromasa Takaishi, Nagamu Inoue, Toshifumi Hibi
DIGESTIVE DISEASES AND SCIENCES Vol. 55 No. 10 p. 2700-2700 2010年10月 研究発表ペーパー・要旨（国際会議）
Tl-1A and IL-23 from CD14+Macrophages Synergistically Enhanced Production of IL-17 and IFN-gamma By Lamina Propria CD4 Memory T Cells in Crohn's Disease
Tadakazu Hisamatsu, Nobuhiko Kamada, Haruki Honda, Taku Kobayashi, Nagamu Inoue, Susumu Okamoto, Toshifumi Hibi
GASTROENTEROLOGY Vol. 136 No. 5 p. A250-A250 2009年5月 研究発表ペーパー・要旨（国際会議）
Bile Acids Contribute to the Differentiation Into Anti-Inflammatory Dcs via TGR5 and cAMP Pathway
Riko Saito, Tadakazu Hisamatsu, Tetsuro Takayama, Nobuhiko Kamada, Yasuyo Wada, Susumu Okamoto, Nagamu Inoue, Toshifumi Hibi
GASTROENTEROLOGY Vol. 136 No. 5 p. A566-A566 2009年5月 研究発表ペーパー・要旨（国際会議）
慢性炎症性疾患病態形成におけるリンパ球の関与 炎症性腸疾患におけるTh1/Th17バランスとIL-23
小林 拓, 岡本 晋, 久松 理一, 鎌田 信彦, 新井 久美子, 日比 紀文
リンパ学 Vol. 31 No. 2 p. 42-44 2008年12月
出版者・発行元：日本リンパ学会合成Retinoic acid receptor(RAR)agonistの樹状細胞分化におけるIL-12産生抑制作用とDSS腸炎の改善効果
和田 安代, 久松 理一, 鎌田 信彦, 岡本 晋, 小林 拓, 知念 寛, 長沼 誠, 高山 哲郎, 高田 康裕, 市川 仁志, 斉藤 理子, 井上 詠, 岩男 泰, 日比 紀文
消化器と免疫 No. 44 p. 77-81 2008年6月
出版者・発行元：日本消化器免疫学会Regulation of colonic CD4+T cell activation by modification of carbohydrate assembly
Kiyotaka Nagahama, Ken Sugimoto, Yasuyo Shimomura, Atsuhiro Ogawa, Akira Andoh, Taku Kobayashi, Nobuhiko Kamada, Tadakazu Hisamatsu, Toshifumi Hibi, Richard S. Blumberg, Atsushi Mizoguchi
GASTROENTEROLOGY Vol. 134 No. 4 p. A73-A73 2008年4月 研究発表ペーパー・要旨（国際会議）
IL-10 knockout and not deficiency suppresses gastric low-grade MALT lymphoma formation by helicobacter heilmannii infection
Masahiko Nakamura, Hidenori Matsui, Hiroshi Serizawa, Shinichi Takahashi, Nobuhiko Kamada, Toshifumi Hibi, Hidekazu Suzuki, Kanji Tsuchimoto
GASTROENTEROLOGY Vol. 134 No. 4 p. A232-A232 2008年4月 研究発表ペーパー・要旨（国際会議）
腸管マクロファージの分化異常が腸内細菌に対する過剰なIL-12, IL-23の産生を介し、Th1優位な慢性大腸炎を引き起こす
鎌田 信彦
慶應医学 Vol. 84 No. 3 p. 9-9 2007年9月
出版者・発行元：慶應医学会
Profiling of amino acids metabolism ("Amino index") is useful for diagnosis, judgment of clinical activity, and understanding of pathophysiology in inflammatory bowel disease
Tadakazu Hisamatsu, Susumu Okamoto, Ayatoshi Andou, Takahiko Muramatsu, Nobuhiko Kamada, Tetsuro Takayama, Yasuhiro Takada, Hitoshi Ichikawa, Motoko Izumiya, Atsushi Sakuraba, Makoto Naganuma, Atsushi Nakazawa, Haruhiko Ogata, Yasushi Iwao, Nobukazu Ono, Ryosei Sakai, Manabu Suzuki, Toshifumi Hibi
GASTROENTEROLOGY Vol. 132 No. 4 p. A359-A360 2007年4月 研究発表ペーパー・要旨（国際会議）
Abnormal innate immune response and Th1/Th17 induction in murine and human inflammatory bowel diseases
Taku Kobayashi, Nobuhiko Kamada, Susumu Okamoto, Tadakazu Hisamatsu, Nagamu Inoue, Toshifumi Hibi
JOURNAL OF IMMUNOLOGY Vol. 178 2007年4月 研究発表ペーパー・要旨（国際会議）
Effect of rebamipide on disruption of tight junctional protein, claudin-1, and trans-epithelial electrical resistance induced by oxidative stress in intestinal inflammation
Haruhiko Ogata, Nobuhiko Kamada, Nagamu Inoue, Toshifumi Hibi
GASTROENTEROLOGY Vol. 132 No. 4 p. A238-A238 2007年4月 研究発表ペーパー・要旨（国際会議）
【自己免疫性消化器疾患】炎症性腸疾患の病態と粘膜免疫 最近の動向
久松 理一, 鎌田 信彦, 小林 拓, 知念 寛, 日比 紀文
細胞 Vol. 38 No. 1 p. 7-10 2006年1月
出版者・発行元：(株)ニュー・サイエンス社