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Nobuhiko Kamada
鎌田　信彦
Nobuhiko Kamada
鎌田　信彦
Immunology Frontier Research Center, Specially Appointed Professor (Full Time)

Research History 5

  1. 2021/09 - Present
    Osaka University　WPI Immunology Frontier Research Center　Specially Appointed Professor

  2. 2020/09 - Present
    University of Michigan　Department of Internal Medicine　Associate Professor

  3. 2013/07 - 2020/08
    University of Michigan　Department of Internal Medicine　Assistant Professor

  4. 2009/04 - 2013/06
    University of Michigan　Department of Pathology　Research Fellow

  5. 2007/10 - 2009/04
    Keio University　School of Medicine　Instructor (Non-tenure)

Research Areas 3

  1. Life sciences / Bacteriology /

  2. Life sciences / Immunology /

  3. Life sciences / Gastroenterology /

Papers 112

  1. Mucolytic bacteria license pathobionts to acquire host-derived nutrients during dietary nutrient restriction.

    Kohei Sugihara, Sho Kitamoto, Prakaimuk Saraithong, Hiroko Nagao-Kitamoto, Matthew Hoostal, Caroline McCarthy, Alexandra Rosevelt, Chithra K Muraleedharan, Merritt G Gillilland 3rd, Jin Imai, Maiko Omi, Shrinivas Bishu, John Y Kao, Christopher J Alteri, Nicolas Barnich, Thomas M Schmidt, Asma Nusrat, Naohiro Inohara, Jonathan L Golob, Nobuhiko Kamada

    Cell reports　Vol. 40　No. 3　p. 111093-111093　2022/07/19　Research paper (scientific journal)

  2. A potential pathogenic association between periodontal disease and Crohn's disease.

    Jin Imai, Hitoshi Ichikawa, Sho Kitamoto, Jonathan L Golob, Motoki Kaneko, Junko Nagata, Miho Takahashi, Merritt G Gillilland, Rika Tanaka, Hiroko Nagao-Kitamoto, Atsushi Hayashi, Kohei Sugihara, Shrinivas Bishu, Shingo Tsuda, Hiroyuki Ito, Seiichiro Kojima, Kazunari Karakida, Masashi Matsushima, Takayoshi Suzuki, Katsuto Hozumi, Norihito Watanabe, William V Giannobile, Takayuki Shirai, Hidekazu Suzuki, Nobuhiko Kamada

    JCI insight　Vol. 6　No. 23　2021/10/28　Research paper (scientific journal)

  3. The Butyrate-Producing Bacterium Clostridium butyricum Suppresses Clostridioides difficile Infection via Neutrophil- and Antimicrobial Cytokine-Dependent but GPR43/109a-Independent Mechanisms.

    Atsushi Hayashi, Hiroko Nagao-Kitamoto, Sho Kitamoto, Chang H Kim, Nobuhiko Kamada

    Journal of immunology (Baltimore, Md. : 1950)　Vol. 206　No. 7　p. 1576-1585　2021/04/01　Research paper (scientific journal)

  4. The Intermucosal Connection between the Mouth and Gut in Commensal Pathobiont-Driven Colitis.

    Sho Kitamoto, Hiroko Nagao-Kitamoto, Yizu Jiao, Merritt G Gillilland 3rd, Atsushi Hayashi, Jin Imai, Kohei Sugihara, Mao Miyoshi, Jennifer C Brazil, Peter Kuffa, Brett D Hill, Syed M Rizvi, Fei Wen, Shrinivas Bishu, Naohiro Inohara, Kathryn A Eaton, Asma Nusrat, Yu L Lei, William V Giannobile, Nobuhiko Kamada

    Cell　Vol. 182　No. 2　p. 447-462　2020/07/23　Research paper (scientific journal)

  5. Interleukin-22-mediated host glycosylation prevents Clostridioides difficile infection by modulating the metabolic activity of the gut microbiota.

    Hiroko Nagao-Kitamoto, Jhansi L Leslie, Sho Kitamoto, Chunsheng Jin, Kristina A Thomsson, Merritt G Gillilland 3rd, Peter Kuffa, Yoshiyuki Goto, Robert R Jenq, Chiharu Ishii, Akiyoshi Hirayama, Anna M Seekatz, Eric C Martens, Kathryn A Eaton, John Y Kao, Shinji Fukuda, Peter D R Higgins, Niclas G Karlsson, Vincent B Young, Nobuhiko Kamada

    Nature medicine　Vol. 26　No. 4　p. 608-617　2020/04　Research paper (scientific journal)

  6. Dietary L-serine confers a competitive fitness advantage to Enterobacteriaceae in the inflamed gut.

    Sho Kitamoto, Christopher J Alteri, Michael Rodrigues, Hiroko Nagao-Kitamoto, Kohei Sugihara, Stephanie D Himpsl, Malak Bazzi, Mao Miyoshi, Tatsuki Nishioka, Atsushi Hayashi, Tina L Morhardt, Peter Kuffa, Helmut Grasberger, Mohamad El-Zaatari, Shrinivas Bishu, Chiharu Ishii, Akiyoshi Hirayama, Kathryn A Eaton, Belgin Dogan, Kenneth W Simpson, Naohiro Inohara, Harry L T Mobley, John Y Kao, Shinji Fukuda, Nicolas Barnich, Nobuhiko Kamada

    Nature microbiology　Vol. 5　No. 1　p. 116-125　2020/01　Research paper (scientific journal)

  7. Flagellin-mediated activation of IL-33-ST2 signaling by a pathobiont promotes intestinal fibrosis.

    Jin Imai, Sho Kitamoto, Kohei Sugihara, Hiroko Nagao-Kitamoto, Atsushi Hayashi, Tina L Morhardt, Peter Kuffa, Peter D R Higgins, Nicolas Barnich, Nobuhiko Kamada

    Mucosal immunology　Vol. 12　No. 3　p. 632-643　2019/05　Research paper (scientific journal)

  8. Functional Characterization of Inflammatory Bowel Disease-Associated Gut Dysbiosis in Gnotobiotic Mice.

    Hiroko Nagao-Kitamoto, Andrew B Shreiner, Merritt G Gillilland 3rd, Sho Kitamoto, Chiharu Ishii, Akiyoshi Hirayama, Peter Kuffa, Mohamad El-Zaatari, Helmut Grasberger, Anna M Seekatz, Peter D R Higgins, Vincent B Young, Shinji Fukuda, John Y Kao, Nobuhiko Kamada

    Cellular and molecular gastroenterology and hepatology　Vol. 2　No. 4　p. 468-481　2016/07　Research paper (scientific journal)

  9. Intestinal macrophages arising from CCR2(+) monocytes control pathogen infection by activating innate lymphoid cells.

    Sang-Uk Seo, Peter Kuffa, Sho Kitamoto, Hiroko Nagao-Kitamoto, Jenna Rousseau, Yun-Gi Kim, Gabriel Núñez, Nobuhiko Kamada

    Nature communications　Vol. 6　p. 8010-8010　2015/08/13　Research paper (scientific journal)

  10. Humoral Immunity in the Gut Selectively Targets Phenotypically Virulent Attaching-and-Effacing Bacteria for Intraluminal Elimination.

    Nobuhiko Kamada, Kei Sakamoto, Sang-Uk Seo, Melody Y Zeng, Yun-Gi Kim, Marilia Cascalho, Bruce A Vallance, José L Puente, Gabriel Núñez

    Cell host & microbe　Vol. 17　No. 5　p. 617-27　2015/05/13　Research paper (scientific journal)

  11. Control of pathogens and pathobionts by the gut microbiota.

    Nobuhiko Kamada, Grace Y Chen, Naohiro Inohara, Gabriel Núñez

    Nature immunology　Vol. 14　No. 7　p. 685-90　2013/07　Research paper (scientific journal)

  12. Role of the gut microbiota in immunity and inflammatory disease.

    Nobuhiko Kamada, Sang-Uk Seo, Grace Y Chen, Gabriel Núñez

    Nature reviews. Immunology　Vol. 13　No. 5　p. 321-35　2013/05　Research paper (scientific journal)

  13. Regulated virulence controls the ability of a pathogen to compete with the gut microbiota.

    Nobuhiko Kamada, Yun-Gi Kim, Ho Pan Sham, Bruce A Vallance, José L Puente, Eric C Martens, Gabriel Núñez

    Science (New York, N.Y.)　Vol. 336　No. 6086　p. 1325-9　2012/06/08　Research paper (scientific journal)

  14. NLRC4-driven production of IL-1β discriminates between pathogenic and commensal bacteria and promotes host intestinal defense.

    Luigi Franchi, Nobuhiko Kamada, Yuumi Nakamura, Aaron Burberry, Peter Kuffa, Shiho Suzuki, Michael H Shaw, Yun-Gi Kim, Gabriel Núñez

    Nature immunology　Vol. 13　No. 5　p. 449-56　2012/05　Research paper (scientific journal)

  15. Unique CD14 intestinal macrophages contribute to the pathogenesis of Crohn disease via IL-23/IFN-gamma axis.

    Nobuhiko Kamada, Tadakazu Hisamatsu, Susumu Okamoto, Hiroshi Chinen, Taku Kobayashi, Toshiro Sato, Atsushi Sakuraba, Mina T Kitazume, Akira Sugita, Kazutaka Koganei, Kiyoko S Akagawa, Toshifumi Hibi

    The Journal of clinical investigation　Vol. 118　No. 6　p. 2269-80　2008/06　Research paper (scientific journal)

  16. A meta-analysis of the gut microbiome in inflammatory bowel disease patients identifies disease-associated small molecules.

    Moamen M Elmassry, Kohei Sugihara, Pranatchareeya Chankhamjon, Yeji Kim, Francine R Camacho, Shuo Wang, Yuki Sugimoto, Seema Chatterjee, Lea Ann Chen, Nobuhiko Kamada, Mohamed S Donia

    Cell host & microbe　Vol. 33　No. 2　p. 218-234　2025/02/12　Research paper (scientific journal)

  17. Inulin-gel-based oral immunotherapy remodels the small intestinal microbiome and suppresses food allergy.

    Kai Han, Fang Xie, Olamide Animasahun, Minal Nenwani, Sho Kitamoto, Yeji Kim, May Thazin Phoo, Jin Xu, Fulei Wuchu, Kehinde Omoloja, Abhinav Achreja, Srinadh Choppara, Zhaoheng Li, Wang Gong, Young Seok Cho, Hannah Dobson, Jinsung Ahn, Xingwu Zhou, Xuehui Huang, Xinran An, Alexander Kim, Yao Xu, Qi Wu, Soo-Hong Lee, Jessica J O'Konek, Yuying Xie, Yu Leo Lei, Nobuhiko Kamada, Deepak Nagrath, James J Moon

    Nature materials　2024/07/08　Research paper (scientific journal)

  18. Metabolic network of the gut microbiota in inflammatory bowel disease.

    Kohei Sugihara, Nobuhiko Kamada

    Inflammation and regeneration　Vol. 44　No. 1　p. 11-11　2024/03/05　Research paper (scientific journal)

  19. Oral pathobiont Klebsiella chaperon usher pili provide site-specific adaptation for the inflamed gut mucosa.

    Yijie Guo, Sho Kitamoto, Gustavo Caballero-Flores, Yeji Kim, Daisuke Watanabe, Kohei Sugihara, Gabriel Núñez, Christopher J Alteri, Naohiro Inohara, Nobuhiko Kamada

    Gut microbes　Vol. 16　No. 1　p. 2333463-2333463　2024　Research paper (scientific journal)

  20. The oral-gut axis: a missing piece in the IBD puzzle.

    Sho Kitamoto, Nobuhiko Kamada

    Inflammation and regeneration　Vol. 43　No. 1　p. 54-54　2023/11/06　Research paper (scientific journal)

  21. クローン病関連大腸菌のcyclic-di-AMPシグナルの亢進

    田中 里佳, 津川 仁, 今井 仁, 鎌田 信彦, 穂積 勝人

    日本細菌学雑誌　Vol. 78　No. 1　p. 76-76　2023/02

    Publisher: 日本細菌学会

  22. クローン病の腸管線維化に影響を与える病原性共生菌の同定とそのメカニズム

    今井 仁, 鈴木 秀和, 西崎 泰弘, 鎌田 信彦

    日本細菌学雑誌　Vol. 78　No. 1　p. 141-141　2023/02

    Publisher: 日本細菌学会

  23. Adherent-invasive E. coli - induced specific IgA limits pathobiont localization to the epithelial niche in the gut.

    Rika Tanaka, Jin Imai, Hitoshi Tsugawa, Karl Bil Eap, Masaki Yazawa, Motoki Kaneko, Masashi Ohno, Kohei Sugihara, Sho Kitamoto, Hiroko Nagao-Kitamoto, Nicolas Barnich, Masashi Matsushima, Takayoshi Suzuki, Tatehiro Kagawa, Yasuhiro Nishizaki, Hidekazu Suzuki, Nobuhiko Kamada, Katsuto Hozumi

    Frontiers in microbiology　Vol. 14　p. 1031997-1031997　2023　Research paper (scientific journal)

  24. Untangling the oral-gut axis in the pathogenesis of intestinal inflammation.

    Sho Kitamoto, Nobuhiko Kamada

    International immunology　Vol. 34　No. 9　p. 485-490　2022/09/06　Research paper (scientific journal)

  25. Inflammatory bowel disease and carcinogenesis

    Hiroko Nagao-Kitamoto, Sho Kitamoto, Nobuhiko Kamada

    Cancer and Metastasis Reviews　2022/04/13　Research paper (scientific journal)

    Publisher: Springer Science and Business Media LLC

  26. Periodontal connection with intestinal inflammation: Microbiological and immunological mechanisms.

    Sho Kitamoto, Nobuhiko Kamada

    Periodontology 2000　2022/03/04　Research paper (scientific journal)

  27. Interaction between the inflammasome and commensal microorganisms in gastrointestinal health and disease.

    Daisuke Watanabe, Yijie Guo, Nobuhiko Kamada

    EMBO molecular medicine　2021/10/27　Research paper (scientific journal)

  28. Oral nanomedicine for modulating immunity, intestinal barrier functions, and gut microbiome.

    Yonghyun Lee, Nobuhiko Kamada, James J Moon

    Advanced drug delivery reviews　p. 114021-114021　2021/10/25　Research paper (scientific journal)

  29. TNFRSF13B polymorphisms counter microbial adaptation to enteric IgA.

    Jeffrey L Platt, Mayara Garcia de Mattos Barbosa, Daniel Huynh, Adam R Lefferts, Juhi Katta, Cyra Kharas, Peter Freddolino, Christine M Bassis, Christiane Wobus, Raif Geha, Richard Bram, Gabriel Nunez, Nobuhiko Kamada, Marilia Cascalho

    JCI insight　Vol. 6　No. 14　2021/07/22　Research paper (scientific journal)

  30. The pathogenic oral-gut-liver axis: new understandings and clinical implications.

    Jin Imai, Sho Kitamoto, Nobuhiko Kamada

    Expert review of clinical immunology　Vol. 17　No. 7　p. 727-736　2021/07　Research paper (scientific journal)

  31. Generation of systemic antitumour immunity via the in situ modulation of the gut microbiome by an orally administered inulin gel.

    Kai Han, Jutaek Nam, Jin Xu, Xiaoqi Sun, Xuehui Huang, Olamide Animasahun, Abhinav Achreja, Jin Heon Jeon, Benjamin Pursley, Nobuhiko Kamada, Grace Y Chen, Deepak Nagrath, James J Moon

    Nature biomedical engineering　2021/06/24　Research paper (scientific journal)

  32. DUOX2 variants associate with preclinical disturbances in microbiota-immune homeostasis and increased inflammatory bowel disease risk.

    Helmut Grasberger, Andrew T Magis, Elisa Sheng, Matthew P Conomos, Min Zhang, Lea S Garzotto, Guoqing Hou, Shrinivas Bishu, Hiroko Nagao-Kitamoto, Mohamad El-Zaatari, Sho Kitamoto, Nobuhiko Kamada, Ryan W Stidham, Yasutada Akiba, Jonathan Kaunitz, Yael Haberman, Subra Kugathasan, Lee A Denson, Gilbert S Omenn, John Y Kao

    The Journal of clinical investigation　Vol. 131　No. 9　2021/05/03　Research paper (scientific journal)

  33. Diet-Microbiota Interactions in Inflammatory Bowel Disease.

    Kohei Sugihara, Nobuhiko Kamada

    Nutrients　Vol. 13　No. 5　2021/05/01　Research paper (scientific journal)

  34. Machine learning-assisted immune profiling stratifies peri-implantitis patients with unique microbial colonization and clinical outcomes.

    Chin-Wei Wang, Yuning Hao, Riccardo Di Gianfilippo, James Sugai, Jiaqian Li, Wang Gong, Kenneth S Kornman, Hom-Lay Wang, Nobuhiko Kamada, Yuying Xie, William V Giannobile, Yu Leo Lei

    Theranostics　Vol. 11　No. 14　p. 6703-6716　2021　Research paper (scientific journal)

  35. Microbial adaptation to the healthy and inflamed gut environments.

    Yijie Guo, Sho Kitamoto, Nobuhiko Kamada

    Gut microbes　Vol. 12　No. 1　p. 1857505-1857505　2020/11/09　Research paper (scientific journal)

  36. Lipopolysaccharide O structure of adherent and invasive Escherichia coli regulates intestinal inflammation via complement C3.

    Masashi Ohno, Mizuho Hasegawa, Atsushi Hayashi, Gustavo Caballero-Flores, Christopher J Alteri, Trevor D Lawley, Nobuhiko Kamada, Gabriel Núñez, Naohiro Inohara

    PLoS pathogens　Vol. 16　No. 10　2020/10　Research paper (scientific journal)

  37. The Bacterial Connection between the Oral Cavity and the Gut Diseases

    S. Kitamoto, H. Nagao-Kitamoto, R. Hein, T.M. Schmidt, N. Kamada

    Journal of Dental Research　Vol. 99　No. 9　p. 1021-1029　2020/08　Research paper (scientific journal)

    Publisher: SAGE Publications

  38. Aim2-mediated/IFN-β-independent regulation of gastric metaplastic lesions via CD8+ T cells.

    Mohamad El-Zaatari, Shrinivas Bishu, Min Zhang, Helmut Grasberger, Guoqing Hou, Henry Haley, Brock Humphries, Li-Jyun Syu, Andrzej A Dlugosz, Kathy Luker, Gary D Luker, Kathryn Eaton, Nobuhiko Kamada, Marilia Cascalho, John Y Kao

    JCI insight　Vol. 5　No. 5　2020/03/12　Research paper (scientific journal)

  39. Hyaluronic acid-bilirubin nanomedicine for targeted modulation of dysregulated intestinal barrier, microbiome and immune responses in colitis.

    Yonghyun Lee, Kohei Sugihara, Merritt G Gillilland 3rd, Sangyong Jon, Nobuhiko Kamada, James J Moon

    Nature materials　Vol. 19　No. 1　p. 118-126　2020/01　Research paper (scientific journal)

  40. CD4+ Tissue-resident Memory T Cells Expand and Are a Major Source of Mucosal Tumour Necrosis Factor α in Active Crohn's Disease.

    Shrinivas Bishu, Mohammed El Zaatari, Atsushi Hayashi, Guoqing Hou, Nicole Bowers, Jami Kinnucan, Beth Manoogian, Michelle Muza-Moons, Min Zhang, Helmut Grasberger, Charlie Bourque, Weiping Zou, Peter D R Higgins, Jason R Spence, Ryan W Stidham, Nobuhiko Kamada, John Y Kao

    Journal of Crohn's & colitis　Vol. 13　No. 7　p. 905-915　2019/07/25　Research paper (scientific journal)

  41. The regenerating family member 3 β instigates IL-17A-mediated neutrophil recruitment downstream of NOD1/2 signalling for controlling colonisation resistance independently of microbiota community structure.

    Nadine Waldschmitt, Sho Kitamoto, Thomas Secher, Vassiliki Zacharioudaki, Olivier Boulard, Emilie Floquet, Myriam Delacre, Bruno Lamas, Hang-Phuong Pham, Adrien Six, Mathias L Richard, Jean-Charles Dagorn, Gérard Eberl, Philippe Langella, Jean-Marc Chatel, Bernhard Ryffel, Juan Lucio Iovanna, Lionel F Poulin, Harry Sokol, Nobuhiko Kamada, Mathias Chamaillard

    Gut　Vol. 68　No. 7　p. 1190-1199　2019/07　Research paper (scientific journal)

  42. Fecal microbiota transplantation prevents Candida albicans from colonizing the gastrointestinal tract.

    Kenzo Matsuo, Akira Haku, Beibei Bi, Hiroki Takahashi, Nobuhiko Kamada, Takashi Yaguchi, Shinobu Saijo, Mitsutoshi Yoneyama, Yoshiyuki Goto

    Microbiology and immunology　Vol. 63　No. 5　p. 155-163　2019/05　Research paper (scientific journal)

  43. Gut pathobionts underlie intestinal barrier dysfunction and liver T helper 17 cell immune response in primary sclerosing cholangitis.

    Nobuhiro Nakamoto, Nobuo Sasaki, Ryo Aoki, Kentaro Miyamoto, Wataru Suda, Toshiaki Teratani, Takahiro Suzuki, Yuzo Koda, Po-Sung Chu, Nobuhito Taniki, Akihiro Yamaguchi, Mitsuhiro Kanamori, Nobuhiko Kamada, Masahira Hattori, Hiroshi Ashida, Michiie Sakamoto, Koji Atarashi, Seiko Narushima, Akihiko Yoshimura, Kenya Honda, Toshiro Sato, Takanori Kanai

    Nature microbiology　Vol. 4　No. 3　p. 492-503　2019/03　Research paper (scientific journal)

  44. IL-10 produced by macrophages regulates epithelial integrity in the small intestine.

    Tina L Morhardt, Atsushi Hayashi, Takanori Ochi, Miguel Quirós, Sho Kitamoto, Hiroko Nagao-Kitamoto, Peter Kuffa, Koji Atarashi, Kenya Honda, John Y Kao, Asma Nusrat, Nobuhiko Kamada

    Scientific reports　Vol. 9　No. 1　p. 1223-1223　2019/02/04　Research paper (scientific journal)

  45. Microbiota-Derived Lactate Accelerates Intestinal Stem-Cell-Mediated Epithelial Development.

    Yong-Soo Lee, Tae-Young Kim, Yeji Kim, Su-Hyun Lee, Seungil Kim, Sung Wan Kang, Jin-Young Yang, In-Jeoung Baek, Young Hoon Sung, Yun-Yong Park, Sung Wook Hwang, Eunju O, Kwang Soon Kim, Siqing Liu, Nobuhiko Kamada, Nan Gao, Mi-Na Kweon

    Cell host & microbe　Vol. 24　No. 6　p. 833-846　2018/12/12　Research paper (scientific journal)

  46. Su1944 - Intestinal Dysbiosis Induces Systemic Dysregulation of Biotin Metabolism, Resulting in Extraintestinal Manifestation

    Yohei Mikami, Atsushi Hayashi, Kentaro Miyamoto, Nobuhiko Kamada, Toshiro Sato, Shinta Mizuno, Makoto Naganuma, Toshiaki Teratani, Ryo Aoki, Shinji Fukuda, Wataru Suda, Masahira Hattori, Masayuki Amagai, Manabu Ohyama, Takanori Kanai

    Gastroenterology　Vol. 154　No. 6　p. S-642　2018/05　Research paper (scientific journal)

    Publisher: Elsevier BV

  47. Regional control of regulatory immune cells in the intestine.

    Tina L Morhardt, Atsushi Hayashi, John Y Kao, Nobuhiko Kamada

    Current pathobiology reports　Vol. 6　No. 1　p. 29-34　2018/03　Research paper (scientific journal)

  48. Bile acid metabolism regulated by the gut microbiota promotes non-alcoholic steatohepatitis-associated hepatocellular carcinoma in mice.

    Shoji Yamada, Yoko Takashina, Mitsuhiro Watanabe, Ryogo Nagamine, Yoshimasa Saito, Nobuhiko Kamada, Hidetsugu Saito

    Oncotarget　Vol. 9　No. 11　p. 9925-9939　2018/02/09　Research paper (scientific journal)

  49. Expression and regulation of proton-coupled oligopeptide transporters in colonic tissue and immune cells of mice.

    Yuqing Wang, Yongjun Hu, Ping Li, Yayun Weng, Nobuhiko Kamada, Huidi Jiang, David E Smith

    Biochemical pharmacology　Vol. 148　p. 163-173　2018/02　Research paper (scientific journal)

  50. Indoleamine 2,3-Dioxygenase 1, Increased in Human Gastric Pre-Neoplasia, Promotes Inflammation and Metaplasia in Mice and Is Associated With Type II Hypersensitivity/Autoimmunity.

    Mohamad El-Zaatari, Adam J Bass, Reanne Bowlby, Min Zhang, Li-Jyun Syu, Yitian Yang, Helmut Grasberger, Andrew Shreiner, Bei Tan, Shrinivas Bishu, Wai K Leung, Andrea Todisco, Nobuhiko Kamada, Marilia Cascalho, Andrzej A Dlugosz, John Y Kao

    Gastroenterology　Vol. 154　No. 1　p. 140-153　2018/01　Research paper (scientific journal)

  51. The Role of Dietary Nutrients in Inflammatory Bowel Disease.

    Kohei Sugihara, Tina L Morhardt, Nobuhiko Kamada

    Frontiers in immunology　Vol. 9　p. 3183-3183　2018　Research paper (scientific journal)

  52. Gut microbiota-mediated generation of saturated fatty acids elicits inflammation in the liver in murine high-fat diet-induced steatohepatitis.

    Shoji Yamada, Nobuhiko Kamada, Takeru Amiya, Nobuhiro Nakamoto, Toshiaki Nakaoka, Masaki Kimura, Yoshimasa Saito, Chieko Ejima, Takanori Kanai, Hidetsugu Saito

    BMC gastroenterology　Vol. 17　No. 1　p. 136-136　2017/11/29　Research paper (scientific journal)

  53. Quantitative proteomics identifies STEAP4 as a critical regulator of mitochondrial dysfunction linking inflammation and colon cancer.

    Xiang Xue, Bryce X Bredell, Erik R Anderson, Angelical Martin, Christopher Mays, Hiroko Nagao-Kitamoto, Sha Huang, Balázs Győrffy, Joel K Greenson, Karin Hardiman, Jason R Spence, Nobuhiko Kamada, Yatrik M Shah

    Proceedings of the National Academy of Sciences of the United States of America　Vol. 114　No. 45　2017/11/07　Research paper (scientific journal)

  54. Commensal Lactobacillus Controls Immune Tolerance during Acute Liver Injury in Mice.

    Nobuhiro Nakamoto, Takeru Amiya, Ryo Aoki, Nobuhito Taniki, Yuzo Koda, Kentaro Miyamoto, Toshiaki Teratani, Takahiro Suzuki, Sayako Chiba, Po-Sung Chu, Atsushi Hayashi, Akihiro Yamaguchi, Shunsuke Shiba, Rei Miyake, Tadashi Katayama, Wataru Suda, Yohei Mikami, Nobuhiko Kamada, Hirotoshi Ebinuma, Hidetsugu Saito, Masahira Hattori, Takanori Kanai

    Cell reports　Vol. 21　No. 5　p. 1215-1226　2017/10/31　Research paper (scientific journal)

  55. Mesenchymal Cell-Specific MyD88 Signaling Promotes Systemic Dissemination of Salmonella Typhimurium via Inflammatory Monocytes.

    Donghyun Kim, Sang-Uk Seo, Melody Y Zeng, Wan-Uk Kim, Nobuhiko Kamada, Naohiro Inohara, Gabriel Núñez

    Journal of immunology (Baltimore, Md. : 1950)　Vol. 199　No. 4　p. 1362-1371　2017/08/15　Research paper (scientific journal)

  56. Intestinal Dysbiosis and Biotin Deprivation Induce Alopecia through Overgrowth of Lactobacillus murinus in Mice.

    Atsushi Hayashi, Yohei Mikami, Kentaro Miyamoto, Nobuhiko Kamada, Toshiro Sato, Shinta Mizuno, Makoto Naganuma, Toshiaki Teratani, Ryo Aoki, Shinji Fukuda, Wataru Suda, Masahira Hattori, Masayuki Amagai, Manabu Ohyama, Takanori Kanai

    Cell reports　Vol. 20　No. 7　p. 1513-1524　2017/08/15　Research paper (scientific journal)

  57. Host-microbial Cross-talk in Inflammatory Bowel Disease.

    Hiroko Nagao-Kitamoto, Nobuhiko Kamada

    Immune network　Vol. 17　No. 1　p. 1-12　2017/02　Research paper (scientific journal)

  58. IL-22 Controls Iron-Dependent Nutritional Immunity Against Systemic Bacterial Infections.

    Kei Sakamoto, Yun-Gi Kim, Hideki Hara, Nobuhiko Kamada, Gustavo Caballero-Flores, Emanuela Tolosano, Miguel P Soares, José L Puente, Naohiro Inohara, Gabriel Núñez

    Science immunology　Vol. 2　No. 8　2017/02　Research paper (scientific journal)

  59. A Dietary Fiber-Deprived Gut Microbiota Degrades the Colonic Mucus Barrier and Enhances Pathogen Susceptibility.

    Mahesh S Desai, Anna M Seekatz, Nicole M Koropatkin, Nobuhiko Kamada, Christina A Hickey, Mathis Wolter, Nicholas A Pudlo, Sho Kitamoto, Nicolas Terrapon, Arnaud Muller, Vincent B Young, Bernard Henrissat, Paul Wilmes, Thaddeus S Stappenbeck, Gabriel Núñez, Eric C Martens

    Cell　Vol. 167　No. 5　p. 1339-1353　2016/11/17　Research paper (scientific journal)

  60. The Innate Immune System: A Trigger for Many Chronic Inflammatory Intestinal Diseases.

    Nobuhiko Kamada, Gerhard Rogler

    Inflammatory intestinal diseases　Vol. 1　No. 2　p. 70-77　2016/07　Research paper (scientific journal)

  61. Diet-dependent, microbiota-independent regulation of IL-10-producing lamina propria macrophages in the small intestine.

    Takanori Ochi, Yongjia Feng, Sho Kitamoto, Hiroko Nagao-Kitamoto, Peter Kuffa, Koji Atarashi, Kenya Honda, Daniel H Teitelbaum, Nobuhiko Kamada

    Scientific reports　Vol. 6　p. 27634-27634　2016/06/15　Research paper (scientific journal)

  62. Nod2-mediated recognition of the microbiota is critical for mucosal adjuvant activity of cholera toxin.

    Donghyun Kim, Yun-Gi Kim, Sang-Uk Seo, Dong-Jae Kim, Nobuhiko Kamada, Dave Prescott, Mathias Chamaillard, Dana J Philpott, Philip Rosenstiel, Naohiro Inohara, Gabriel Núñez

    Nature medicine　Vol. 22　No. 5　p. 524-30　2016/05　Research paper (scientific journal)

  63. Pathogenic role of the gut microbiota in gastrointestinal diseases.

    Hiroko Nagao-Kitamoto, Sho Kitamoto, Peter Kuffa, Nobuhiko Kamada

    Intestinal research　Vol. 14　No. 2　p. 127-38　2016/04　Research paper (scientific journal)

  64. Regulation of virulence: the rise and fall of gastrointestinal pathogens.

    Sho Kitamoto, Hiroko Nagao-Kitamoto, Peter Kuffa, Nobuhiko Kamada

    Journal of gastroenterology　Vol. 51　No. 3　p. 195-205　2016/03　Research paper (scientific journal)

  65. Increased Expression of DUOX2 Is an Epithelial Response to Mucosal Dysbiosis Required for Immune Homeostasis in Mouse Intestine.

    Helmut Grasberger, Jun Gao, Hiroko Nagao-Kitamoto, Sho Kitamoto, Min Zhang, Nobuhiko Kamada, Kathryn A Eaton, Mohamad El-Zaatari, Andrew B Shreiner, Juanita L Merchant, Chung Owyang, John Y Kao

    Gastroenterology　Vol. 149　No. 7　p. 1849-59　2015/12　Research paper (scientific journal)

  66. Th17 Cell Induction by Adhesion of Microbes to Intestinal Epithelial Cells.

    Koji Atarashi, Takeshi Tanoue, Minoru Ando, Nobuhiko Kamada, Yuji Nagano, Seiko Narushima, Wataru Suda, Akemi Imaoka, Hiromi Setoyama, Takashi Nagamori, Eiji Ishikawa, Tatsuichiro Shima, Taeko Hara, Shoichi Kado, Toshi Jinnohara, Hiroshi Ohno, Takashi Kondo, Kiminori Toyooka, Eiichiro Watanabe, Shin-Ichiro Yokoyama, Shunji Tokoro, Hiroshi Mori, Yurika Noguchi, Hidetoshi Morita, Ivaylo I Ivanov, Tsuyoshi Sugiyama, Gabriel Nuñez, J Gray Camp, Masahira Hattori, Yoshinori Umesaki, Kenya Honda

    Cell　Vol. 163　No. 2　p. 367-80　2015/10/08　Research paper (scientific journal)

  67. Distinct Commensals Induce Interleukin-1β via NLRP3 Inflammasome in Inflammatory Monocytes to Promote Intestinal Inflammation in Response to Injury.

    Sang-Uk Seo, Nobuhiko Kamada, Raúl Muñoz-Planillo, Yun-Gi Kim, Donghyun Kim, Yukiko Koizumi, Mizuho Hasegawa, Stephanie D Himpsl, Hilary P Browne, Trevor D Lawley, Harry L T Mobley, Naohiro Inohara, Gabriel Núñez

    Immunity　Vol. 42　No. 4　p. 744-55　2015/04/21　Research paper (scientific journal)

  68. TACI deficiency enhances antibody avidity and clearance of an intestinal pathogen.

    Shoichiro Tsuji, Lucas Stein, Nobuhiko Kamada, Gabriel Nuñez, Richard Bram, Bruce A Vallance, Ana E Sousa, Jeffrey L Platt, Marilia Cascalho

    The Journal of clinical investigation　Vol. 124　No. 11　p. 4857-66　2014/11　Research paper (scientific journal)

  69. Interleukin-22 regulates the complement system to promote resistance against pathobionts after pathogen-induced intestinal damage.

    Mizuho Hasegawa, Shoko Yada, Meng Zhen Liu, Nobuhiko Kamada, Raúl Muñoz-Planillo, Nhu Do, Gabriel Núñez, Naohiro Inohara

    Immunity　Vol. 41　No. 4　p. 620-32　2014/10/16　Research paper (scientific journal)

  70. Cross-talk between RORγt+ innate lymphoid cells and intestinal macrophages induces mucosal IL-22 production in Crohn's disease.

    Shinta Mizuno, Yohei Mikami, Nobuhiko Kamada, Tango Handa, Atsushi Hayashi, Toshiro Sato, Katsuyoshi Matsuoka, Mami Matano, Yuki Ohta, Akira Sugita, Kazutaka Koganei, Rikisaburo Sahara, Masakazu Takazoe, Tadakazu Hisamatsu, Takanori Kanai

    Inflammatory bowel diseases　Vol. 20　No. 8　p. 1426-34　2014/08　Research paper (scientific journal)

  71. Tryptophan catabolism restricts IFN-γ-expressing neutrophils and Clostridium difficile immunopathology.

    Mohamad El-Zaatari, Yu-Ming Chang, Min Zhang, Matthew Franz, Andrew Shreiner, Andrew J McDermott, Koenraad F van der Sluijs, René Lutter, Helmut Grasberger, Nobuhiko Kamada, Vincent B Young, Gary B Huffnagle, John Y Kao

    Journal of immunology (Baltimore, Md. : 1950)　Vol. 193　No. 2　p. 807-16　2014/07/15　Research paper (scientific journal)

  72. Regulation of the immune system by the resident intestinal bacteria.

    Nobuhiko Kamada, Gabriel Núñez

    Gastroenterology　Vol. 146　No. 6　p. 1477-88　2014/05　Research paper (scientific journal)

  73. Macrophages and dendritic cells emerge in the liver during intestinal inflammation and predispose the liver to inflammation.

    Yohei Mikami, Shinta Mizuno, Nobuhiro Nakamoto, Atsushi Hayashi, Tomohisa Sujino, Toshiro Sato, Nobuhiko Kamada, Katsuyoshi Matsuoka, Tadakazu Hisamatsu, Hirotoshi Ebinuma, Toshifumi Hibi, Akihiko Yoshimura, Takanori Kanai

    PloS one　Vol. 9　No. 1　2014　Research paper (scientific journal)

  74. The tuning of the gut nervous system by commensal microbiota.

    Nobuhiko Kamada, John Y Kao

    Gastroenterology　Vol. 145　No. 6　p. 1193-6　2013/12

  75. Clinical strategies for the blockade of IL-18 in inflammatory bowel diseases.

    Takanori Kanai, Nobuhiko Kamada, Tadakazu Hisamatsu

    Current drug targets　Vol. 14　No. 12　p. 1392-9　2013/11　Research paper (scientific journal)

  76. Multiple effects of dendritic cell depletion on murine norovirus infection.

    Michael D Elftman, Mariam B Gonzalez-Hernandez, Nobuhiko Kamada, Cheryl Perkins, Kenneth S Henderson, Gabriel Núñez, Christiane E Wobus

    The Journal of general virology　Vol. 94　No. Pt 8　p. 1761-1768　2013/08　Research paper (scientific journal)

  77. Establishment of novel prediction system of intestinal absorption in humans using human intestinal tissues.

    Masateru Miyake, Hajime Toguchi, Toru Nishibayashi, Kazutaka Higaki, Akira Sugita, Kazutaka Koganei, Nobuhiko Kamada, Mina T Kitazume, Tadakazu Hisamatsu, Toshiro Sato, Susumu Okamoto, Takanori Kanai, Toshifumi Hibi

    Journal of pharmaceutical sciences　Vol. 102　No. 8　p. 2564-71　2013/08　Research paper (scientific journal)

  78. A single strain of Clostridium butyricum induces intestinal IL-10-producing macrophages to suppress acute experimental colitis in mice.

    Atsushi Hayashi, Toshiro Sato, Nobuhiko Kamada, Yohei Mikami, Katsuyoshi Matsuoka, Tadakazu Hisamatsu, Toshifumi Hibi, Axel Roers, Hideo Yagita, Toshiaki Ohteki, Akihiko Yoshimura, Takanori Kanai

    Cell host & microbe　Vol. 13　No. 6　p. 711-22　2013/06/12　Research paper (scientific journal)

  79. Activated hepatic stellate cells mediate the differentiation of macrophages.

    Jonathan Chang, Tadakazu Hisamatsu, Katsuyoshi Shimamura, Kazuaki Yoneno, Masayuki Adachi, Hiroshi Naruse, Toru Igarashi, Hajime Higuchi, Katsuyoshi Matsuoka, Mina T Kitazume, Setsu Ando, Nobuhiko Kamada, Takanori Kanai, Toshifumi Hibi

    Hepatology research : the official journal of the Japan Society of Hepatology　Vol. 43　No. 6　p. 658-69　2013/06　Research paper (scientific journal)

  80. Tu1976 Clostridium Butyricum Regulates IL-10 Production in Normal and Inflammatory Conditions Through Different Target Cells

    Atsushi Hayashi, Takanori Kanai, Toshiro Sato, Yohei Mikami, Katsuyoshi Matsuoka, Tadakazu Hisamatsu, Akihiko Yoshimura, Nobuhiko Kamada, Hideo Yagita, Toshifumi Hibi

    Gastroenterology　Vol. 144　No. 5　p. S-895　2013/05　Research paper (scientific journal)

    Publisher: Elsevier BV

  81. TGR5 signalling inhibits the production of pro-inflammatory cytokines by in vitro differentiated inflammatory and intestinal macrophages in Crohn's disease.

    Kazuaki Yoneno, Tadakazu Hisamatsu, Katsuyoshi Shimamura, Nobuhiko Kamada, Riko Ichikawa, Mina T Kitazume, Maiko Mori, Michihide Uo, Yuka Namikawa, Katsuyoshi Matsuoka, Toshiro Sato, Kazutaka Koganei, Akira Sugita, Takanori Kanai, Toshifumi Hibi

    Immunology　Vol. 139　No. 1　p. 19-29　2013/05　Research paper (scientific journal)

  82. Role of the gut microbiota in the development and function of lymphoid cells.

    Nobuhiko Kamada, Gabriel Núñez

    Journal of immunology (Baltimore, Md. : 1950)　Vol. 190　No. 4　p. 1389-95　2013/02/15　Research paper (scientific journal)

  83. Protective role of commensals against Clostridium difficile infection via an IL-1β-mediated positive-feedback loop.

    Mizuho Hasegawa, Nobuhiko Kamada, Yizu Jiao, Meng Zhen Liu, Gabriel Núñez, Naohiro Inohara

    Journal of immunology (Baltimore, Md. : 1950)　Vol. 189　No. 6　p. 3085-91　2012/09/15　Research paper (scientific journal)

  84. A complex microworld in the gut: Harnessing pathogen-commensal relations.

    Nobuhiko Kamada, Grace Chen, Gabriel Núñez

    Nature medicine　Vol. 18　No. 8　p. 1190-1　2012/08　Research paper (scientific journal)

  85. Bile acids induce monocyte differentiation toward interleukin-12 hypo-producing dendritic cells via a TGR5-dependent pathway.

    Riko Ichikawa, Tetsuro Takayama, Kazuaki Yoneno, Nobuhiko Kamada, Mina T Kitazume, Hajime Higuchi, Katsuyoshi Matsuoka, Mitsuhiro Watanabe, Hiroshi Itoh, Takanori Kanai, Tadakazu Hisamatsu, Toshifumi Hibi

    Immunology　Vol. 136　No. 2　p. 153-62　2012/06　Research paper (scientific journal)

  86. Mo1783 New Immunosuppressive System by Myeloid-Derived Suppressor Cells in the Lamina Propria of Ulcerative Colitis Patients

    Yohei Mikami, Takanori Kanai, Shinta Mizuno, Tomohisa Sujino, Tango Handa, Atsuhiro Matsumoto, Toshiro Sato, Nobuhiko Kamada, Katsuyoshi Matsuoka, Tadakazu Hisamatsu, Akira Sonoda, Masakazu Takazoe, Rikisaburo Sahara, Kazutaka Koganei, Akira Sugita, Toshifumi Hibi

    Gastroenterology　Vol. 142　No. 5　p. S-684　2012/05　Research paper (scientific journal)

    Publisher: Elsevier BV

  87. Microbiota-induced IL-1β, but not IL-6, is critical for the development of steady-state TH17 cells in the intestine.

    Michael H Shaw, Nobuhiko Kamada, Yun-Gi Kim, Gabriel Núñez

    The Journal of experimental medicine　Vol. 209　No. 2　p. 251-8　2012/02/13　Research paper (scientific journal)

  88. Both exogenous commensal and endogenous self antigens stimulate T cell proliferation under lymphopenic conditions.

    Jeong-su Do, Gilles Foucras, Nobuhiko Kamada, Austin F Schenk, Michael Shaw, Gabriel Nuñez, William E Paul, Booki Min

    Cellular immunology　Vol. 272　No. 2　p. 117-23　2012　Research paper (scientific journal)

  89. The Nod2 sensor promotes intestinal pathogen eradication via the chemokine CCL2-dependent recruitment of inflammatory monocytes.

    Yun-Gi Kim, Nobuhiko Kamada, Michael H Shaw, Neil Warner, Grace Y Chen, Luigi Franchi, Gabriel Núñez

    Immunity　Vol. 34　No. 5　p. 769-80　2011/05/27　Research paper (scientific journal)

  90. NFIL3 is a regulator of IL-12 p40 in macrophages and mucosal immunity.

    Taku Kobayashi, Katsuyoshi Matsuoka, Shehzad Z Sheikh, Houda Z Elloumi, Nobuhiko Kamada, Tadakazu Hisamatsu, Jonathan J Hansen, Kevin R Doty, Scott D Pope, Stephen T Smale, Toshifumi Hibi, Paul B Rothman, Masaki Kashiwada, Scott E Plevy

    Journal of immunology (Baltimore, Md. : 1950)　Vol. 186　No. 8　p. 4649-55　2011/04/15　Research paper (scientific journal)

  91. Nucleotide-binding oligomerization domain 1 mediates recognition of Clostridium difficile and induces neutrophil recruitment and protection against the pathogen.

    Mizuho Hasegawa, Takashi Yamazaki, Nobuhiko Kamada, Kazuki Tawaratsumida, Yun-Gi Kim, Gabriel Núñez, Naohiro Inohara

    Journal of immunology (Baltimore, Md. : 1950)　Vol. 186　No. 8　p. 4872-80　2011/04/15　Research paper (scientific journal)

  92. The ever-expanding function of NOD2: autophagy, viral recognition, and T cell activation.

    Michael H Shaw, Nobuhiko Kamada, Neil Warner, Yun-Gi Kim, Gabriel Nuñez

    Trends in immunology　Vol. 32　No. 2　p. 73-9　2011/02　Research paper (scientific journal)

  93. Imbalance of NKp44(+)NKp46(-) and NKp44(-)NKp46(+) natural killer cells in the intestinal mucosa of patients with Crohn's disease.

    Tetsuro Takayama, Nobuhiko Kamada, Hiroshi Chinen, Susumu Okamoto, Mina T Kitazume, Jonathan Chang, Yumi Matuzaki, Sadafumi Suzuki, Akira Sugita, Kazutaka Koganei, Tadakazu Hisamatsu, Takanori Kanai, Toshifumi Hibi

    Gastroenterology　Vol. 139　No. 3　p. 882-92　2010/09　Research paper (scientific journal)

  94. Competition between colitogenic Th1 and Th17 cells contributes to the amelioration of colitis.

    Yohei Mikami, Takanori Kanai, Tomohisa Sujino, Yuichi Ono, Atsushi Hayashi, Akira Okazawa, Nobuhiko Kamada, Katsuyoshi Matsuoka, Tadakazu Hisamatsu, Susumu Okamoto, Hiromasa Takaishi, Nagamu Inoue, Haruhiko Ogata, Toshifumi Hibi

    European journal of immunology　Vol. 40　No. 9　p. 2409-22　2010/09　Research paper (scientific journal)

  95. TL1A produced by lamina propria macrophages induces Th1 and Th17 immune responses in cooperation with IL-23 in patients with Crohn's disease.

    Nobuhiko Kamada, Tadakazu Hisamatsu, Haruki Honda, Taku Kobayashi, Hiroshi Chinen, Tetsuro Takayama, Mina T Kitazume, Susumu Okamoto, Kazutaka Koganei, Akira Sugita, Takanori Kanai, Toshifumi Hibi

    Inflammatory bowel diseases　Vol. 16　No. 4　p. 568-75　2010/04　Research paper (scientific journal)

  96. Monocyte chemoattractant protein-1 contributes to gut homeostasis and intestinal inflammation by composition of IL-10-producing regulatory macrophage subset.

    Yasuhiro Takada, Tadakazu Hisamatsu, Nobuhiko Kamada, Mina T Kitazume, Haruki Honda, Yosuke Oshima, Riko Saito, Tetsuro Takayama, Taku Kobayashi, Hiroshi Chinen, Yohei Mikami, Takanori Kanai, Susumu Okamoto, Toshifumi Hibi

    Journal of immunology (Baltimore, Md. : 1950)　Vol. 184　No. 5　p. 2671-6　2010/03/01　Research paper (scientific journal)

  97. Th1/Th17 immune response is induced by mesenteric lymph node dendritic cells in Crohn's disease.

    Atsushi Sakuraba, Toshiro Sato, Nobuhiko Kamada, Mina Kitazume, Akira Sugita, Toshifumi Hibi

    Gastroenterology　Vol. 137　No. 5　p. 1736-45　2009/11　Research paper (scientific journal)

  98. Retinoic acid contributes to the induction of IL-12-hypoproducing dendritic cells.

    Yasuyo Wada, Tadakazu Hisamatsu, Nobuhiko Kamada, Susumu Okamoto, Toshifumi Hibi

    Inflammatory bowel diseases　Vol. 15　No. 10　p. 1548-56　2009/10　Research paper (scientific journal)

  99. Human CD14+ macrophages in intestinal lamina propria exhibit potent antigen-presenting ability.

    Nobuhiko Kamada, Tadakazu Hisamatsu, Haruki Honda, Taku Kobayashi, Hiroshi Chinen, Mina Tokutake Kitazume, Tetsuro Takayama, Susumu Okamoto, Kazutaka Koganei, Akira Sugita, Takanori Kanai, Toshifumi Hibi

    Journal of immunology (Baltimore, Md. : 1950)　Vol. 183　No. 3　p. 1724-31　2009/08/01　Research paper (scientific journal)

  100. Homeostatic (IL-7) and effector (IL-17) cytokines as distinct but complementary target for an optimal therapeutic strategy in inflammatory bowel disease.

    Takanori Kanai, Yasuhiro Nemoto, Nobuhiko Kamada, Teruji Totsuka, Tadakazu Hisamatsu, Mamoru Watanabe, Toshifumi Hibi

    Current opinion in gastroenterology　Vol. 25　No. 4　p. 306-13　2009/07　Research paper (scientific journal)

  101. [Pathogenic roles of intestinal macrophages in inflammatory bowel disease].

    Nobuhiko Kamada, Toshifumi Hibi

    Nihon yakurigaku zasshi. Folia pharmacologica Japonica　Vol. 133　No. 4　p. 186-9　2009/04　Research paper (scientific journal)

  102. Dietary histidine ameliorates murine colitis by inhibition of proinflammatory cytokine production from macrophages.

    Ayatoshi Andou, Tadakazu Hisamatsu, Susumu Okamoto, Hiroshi Chinen, Nobuhiko Kamada, Taku Kobayashi, Masaki Hashimoto, Tomohisa Okutsu, Kazutaka Shimbo, Tomoko Takeda, Hideki Matsumoto, Atsushi Sato, Hiroshi Ohtsu, Manabu Suzuki, Toshifumi Hibi

    Gastroenterology　Vol. 136　No. 2　p. 564-74　2009/02　Research paper (scientific journal)

  103. IL23 differentially regulates the Th1/Th17 balance in ulcerative colitis and Crohn's disease.

    T Kobayashi, S Okamoto, T Hisamatsu, N Kamada, H Chinen, R Saito, M T Kitazume, A Nakazawa, A Sugita, K Koganei, K Isobe, T Hibi

    Gut　Vol. 57　No. 12　p. 1682-9　2008/12　Research paper (scientific journal)

  104. Tetomilast suppressed production of proinflammatory cytokines from human monocytes and ameliorated chronic colitis in IL-10-deficient mice.

    Hitoshi Ichikawa, Susumu Okamoto, Nobuhiko Kamada, Hisashi Nagamoto, Mina T Kitazume, Taku Kobayashi, Hiroshi Chinen, Tadakazu Hisamatsu, Toshifumi Hibi

    Inflammatory bowel diseases　Vol. 14　No. 11　p. 1483-90　2008/11　Research paper (scientific journal)

  105. Imbalance in intestinal microflora constitution could be involved in the pathogenesis of inflammatory bowel disease.

    Hiromasa Takaishi, Takahiro Matsuki, Atsushi Nakazawa, Toshihiko Takada, Shoichi Kado, Takashi Asahara, Nobuhiko Kamada, Atsushi Sakuraba, Tomoharu Yajima, Hajime Higuchi, Nagamu Inoue, Haruhiko Ogata, Yasushi Iwao, Koji Nomoto, Ryuichiro Tanaka, Toshifumi Hibi

    International journal of medical microbiology : IJMM　Vol. 298　No. 5-6　p. 463-72　2008/07　Research paper (scientific journal)

  106. Nonpathogenic Escherichia coli strain Nissle 1917 inhibits signal transduction in intestinal epithelial cells.

    Nobuhiko Kamada, Kenichi Maeda, Nagamu Inoue, Tadakazu Hisamatsu, Susumu Okamoto, Kyong Su Hong, Takaya Yamada, Noriaki Watanabe, Kanji Tsuchimoto, Haruhiko Ogata, Toshifumi Hibi

    Infection and immunity　Vol. 76　No. 1　p. 214-20　2008/01　Research paper (scientific journal)

  107. Lamina propria c-kit+ immune precursors reside in human adult intestine and differentiate into natural killer cells.

    Hiroshi Chinen, Katsuyoshi Matsuoka, Toshiro Sato, Nobuhiko Kamada, Susumu Okamoto, Tadakazu Hisamatsu, Taku Kobayashi, Hirotoshi Hasegawa, Akira Sugita, Fukunori Kinjo, Jiro Fujita, Toshifumi Hibi

    Gastroenterology　Vol. 133　No. 2　p. 559-73　2007/08　Research paper (scientific journal)

  108. Exclusive increase of CX3CR1+CD28-CD4+ T cells in inflammatory bowel disease and their recruitment as intraepithelial lymphocytes.

    Taku Kobayashi, Susumu Okamoto, Yuko Iwakami, Atsushi Nakazawa, Tadakazu Hisamatsu, Hiroshi Chinen, Nobuhiko Kamada, Toshio Imai, Hidemi Goto, Toshifumi Hibi

    Inflammatory bowel diseases　Vol. 13　No. 7　p. 837-46　2007/07　Research paper (scientific journal)

  109. Inhibition of neutrophil elastase prevents the development of murine dextran sulfate sodium-induced colitis.

    Yuichi Morohoshi, Katsuyoshi Matsuoka, Hiroshi Chinen, Nobuhiko Kamada, Toshiro Sato, Tadakazu Hisamatsu, Susumu Okamoto, Nagamu Inoue, Hiromasa Takaishi, Haruhiko Ogata, Yasushi Iwao, Toshifumi Hibi

    Journal of gastroenterology　Vol. 41　No. 4　p. 318-24　2006/04　Research paper (scientific journal)

  110. Abnormally differentiated subsets of intestinal macrophage play a key role in Th1-dominant chronic colitis through excess production of IL-12 and IL-23 in response to bacteria.

    Nobuhiko Kamada, Tadakazu Hisamatsu, Susumu Okamoto, Toshiro Sato, Katsuyoshi Matsuoka, Kumiko Arai, Takaaki Nakai, Akira Hasegawa, Nagamu Inoue, Noriaki Watanabe, Kiyoko S Akagawa, Toshifumi Hibi

    Journal of immunology (Baltimore, Md. : 1950)　Vol. 175　No. 10　p. 6900-8　2005/11/15　Research paper (scientific journal)

  111. A novel apoptosis-inducing monoclonal antibody (anti-LHK) against a cell surface antigen on colon cancer cells.

    Hidehiko Matsukawa, Takanori Kanai, Makoto Naganuma, Nobuhiko Kamada, Tadakazu Hisamatsu, Hiromasa Takaishi, Haruhiko Ogata, Makio Mukai, Hiromasa Ishii, Tsuneyo Mimori, Mamoru Watanabe, Toshifumi Hibi

    Journal of gastroenterology　Vol. 40　No. 10　p. 945-55　2005/10　Research paper (scientific journal)

  112. Nonpathogenic Escherichia coli strain Nissle1917 prevents murine acute and chronic colitis.

    Nobuhiko Kamada, Nagamu Inoue, Tadakazu Hisamatsu, Susumu Okamoto, Katsuyoshi Matsuoka, Toshiro Sato, Hiroshi Chinen, Kyong Su Hong, Takaya Yamada, Yumiko Suzuki, Tatsuo Suzuki, Noriaki Watanabe, Kanji Tsuchimoto, Toshifumi Hibi

    Inflammatory bowel diseases　Vol. 11　No. 5　p. 455-63　2005/05　Research paper (scientific journal)

Misc. 15

  1. 消化管におけるtranslational research 歯周病合併クローン病における口腔内・腸内細菌叢解析と臨床経過

    今井 仁, 鎌田 信彦, 北本 祥, 市川 仁志, 高橋 美穂, 白井 孝之, 穂積 勝人, 鈴木 秀和

    日本消化管学会雑誌　Vol. 5　No. Suppl.　p. 171-171　2021/01

    Publisher: (一社)日本消化管学会

  2. Oral and gut microbiome analysis and clinical course in Crohn’s disease with periodontitis

    今井仁, 今井仁, 鎌田信彦, 北本祥, 市川仁志, 高橋美穂, 白井孝之, 穂積勝人, 鈴木秀和

    日本消化管学会雑誌　Vol. 5　No. Supplement　2021

  3. 接着性侵入性大腸菌(AIEC)はIL-33/ST2シグナルを介し腸管線維化を誘導する

    今井 仁, 鈴木 孝良, 鎌田 信彦

    日本消化器病学会雑誌　Vol. 116　No. 臨増大会　p. A796-A796　2019/11

    Publisher: (一財)日本消化器病学会

  4. Competition Between Colitogenic T Helper 1 and 17 CD4(+) T Cells Contributes to the Amelioration of Colitis

    Yohei Mikami, Takanori Kanai, Akira Okazawa, Yuichi Ono, Atsushi Hayashi, Tomohisa Sujino, Nobuhiko Kamada, Katsuyoshi Matsuoka, Tadakazu Hisamatsu, Susumu Okamoto, Hiromasa Takaishi, Nagamu Inoue, Toshifumi Hibi

    DIGESTIVE DISEASES AND SCIENCES　Vol. 55　No. 10　p. 2700-2700　2010/10　Research paper, summary (international conference)

  5. Tl-1A and IL-23 from CD14+Macrophages Synergistically Enhanced Production of IL-17 and IFN-gamma By Lamina Propria CD4 Memory T Cells in Crohn's Disease

    Tadakazu Hisamatsu, Nobuhiko Kamada, Haruki Honda, Taku Kobayashi, Nagamu Inoue, Susumu Okamoto, Toshifumi Hibi

    GASTROENTEROLOGY　Vol. 136　No. 5　p. A250-A250　2009/05　Research paper, summary (international conference)

  6. Bile Acids Contribute to the Differentiation Into Anti-Inflammatory Dcs via TGR5 and cAMP Pathway

    Riko Saito, Tadakazu Hisamatsu, Tetsuro Takayama, Nobuhiko Kamada, Yasuyo Wada, Susumu Okamoto, Nagamu Inoue, Toshifumi Hibi

    GASTROENTEROLOGY　Vol. 136　No. 5　p. A566-A566　2009/05　Research paper, summary (international conference)

  7. 慢性炎症性疾患病態形成におけるリンパ球の関与 炎症性腸疾患におけるTh1/Th17バランスとIL-23

    小林 拓, 岡本 晋, 久松 理一, 鎌田 信彦, 新井 久美子, 日比 紀文

    リンパ学　Vol. 31　No. 2　p. 42-44　2008/12

    Publisher: 日本リンパ学会

  8. 合成Retinoic acid receptor(RAR)agonistの樹状細胞分化におけるIL-12産生抑制作用とDSS腸炎の改善効果

    和田 安代, 久松 理一, 鎌田 信彦, 岡本 晋, 小林 拓, 知念 寛, 長沼 誠, 高山 哲郎, 高田 康裕, 市川 仁志, 斉藤 理子, 井上 詠, 岩男 泰, 日比 紀文

    消化器と免疫　No. 44　p. 77-81　2008/06

    Publisher: 日本消化器免疫学会

  9. Regulation of colonic CD4+T cell activation by modification of carbohydrate assembly

    Kiyotaka Nagahama, Ken Sugimoto, Yasuyo Shimomura, Atsuhiro Ogawa, Akira Andoh, Taku Kobayashi, Nobuhiko Kamada, Tadakazu Hisamatsu, Toshifumi Hibi, Richard S. Blumberg, Atsushi Mizoguchi

    GASTROENTEROLOGY　Vol. 134　No. 4　p. A73-A73　2008/04　Research paper, summary (international conference)

  10. IL-10 knockout and not deficiency suppresses gastric low-grade MALT lymphoma formation by helicobacter heilmannii infection

    Masahiko Nakamura, Hidenori Matsui, Hiroshi Serizawa, Shinichi Takahashi, Nobuhiko Kamada, Toshifumi Hibi, Hidekazu Suzuki, Kanji Tsuchimoto

    GASTROENTEROLOGY　Vol. 134　No. 4　p. A232-A232　2008/04　Research paper, summary (international conference)

  11. Abnormally Differentiated Subsets of lntestinal Macrophage Play a Key Role in Th1-Dominant Chronic Colitis through Excess Production of IL-12 and IL-23 in Response to Bacteria

    Vol. 84　No. 3　p. 9-9　2007/09

    Publisher: 慶應医学会

  12. Profiling of amino acids metabolism ("Amino index") is useful for diagnosis, judgment of clinical activity, and understanding of pathophysiology in inflammatory bowel disease

    Tadakazu Hisamatsu, Susumu Okamoto, Ayatoshi Andou, Takahiko Muramatsu, Nobuhiko Kamada, Tetsuro Takayama, Yasuhiro Takada, Hitoshi Ichikawa, Motoko Izumiya, Atsushi Sakuraba, Makoto Naganuma, Atsushi Nakazawa, Haruhiko Ogata, Yasushi Iwao, Nobukazu Ono, Ryosei Sakai, Manabu Suzuki, Toshifumi Hibi

    GASTROENTEROLOGY　Vol. 132　No. 4　p. A359-A360　2007/04　Research paper, summary (international conference)

  13. Abnormal innate immune response and Th1/Th17 induction in murine and human inflammatory bowel diseases

    Taku Kobayashi, Nobuhiko Kamada, Susumu Okamoto, Tadakazu Hisamatsu, Nagamu Inoue, Toshifumi Hibi

    JOURNAL OF IMMUNOLOGY　Vol. 178　2007/04　Research paper, summary (international conference)

  14. Effect of rebamipide on disruption of tight junctional protein, claudin-1, and trans-epithelial electrical resistance induced by oxidative stress in intestinal inflammation

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    GASTROENTEROLOGY　Vol. 132　No. 4　p. A238-A238　2007/04　Research paper, summary (international conference)

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    Publisher: (株)ニュー・サイエンス社