Systematic evaluation of AML-associated antigens identifies anti-U5 SNRNP200 therapeutic antibodies for the treatment of acute myeloid leukemia

Katherine Knorr, Jahan Rahman, Caroline Erickson, Eric Wang, Mara Monetti, Zhuoning Li, Juliana Ortiz-Pacheco, Andrew Jones, Sydney X. Lu, Robert F. Stanley, Maria Baez, Nina Fox, Cynthia Castro, Alessandra E. Marino, Caroline Jiang, Alex Penson, Simon J. Hogg, Xiaoli Mi, Hideaki Nakajima, Hiroyoshi Kunimoto, Koutarou Nishimura, Daichi Inoue, Benjamin Greenbaum, David Knorr, Jeffrey Ravetch, Omar Abdel-Wahab

Nature Cancer　2023年10月23日　研究論文（学術雑誌）

SETBP1 is dispensable for normal and malignant hematopoiesis.

Atsushi Tanaka, Koutarou Nishimura, Wataru Saika, Ayana Kon, Yui Koike, Hiromi Tatsumi, June Takeda, Masaki Nomura, Weijia Zang, Manabu Nakayama, Masashi Matsuda, Hiromi Yamazaki, Miki Fukumoto, Hiromi Ito, Yasutaka Hayashi, Toshio Kitamura, Hiroshi Kawamoto, Akifumi Takaori-Kondo, Haruhiko Koseki, Seishi Ogawa, Daichi Inoue

Leukemia　2023年7月18日　研究論文（学術雑誌）

Extracellular vesicle-mediated remodeling of the bone marrow microenvironment in myeloid malignancies.

Yasutaka Hayashi, Koutarou Nishimura, Atsushi Tanaka, Daichi Inoue

International journal of hematology　2023年4月12日　研究論文（学術雑誌）

Exploring the mechanistic link between SF3B1 mutation and ring sideroblast formation in myelodysplastic syndrome.

Tetsuro Ochi, Tohru Fujiwara, Koya Ono, Chie Suzuki, Maika Nikaido, Daichi Inoue, Hiroki Kato, Koichi Onodera, Satoshi Ichikawa, Noriko Fukuhara, Yasushi Onishi, Hisayuki Yokoyama, Yukio Nakamura, Hideo Harigae

Scientific Reports　Vol. 12　No. 1　p. 14562-14562　2022年8月26日　研究論文（学術雑誌）

Impaired proteolysis of non-canonical RAS proteins drives clonal hematopoietic transformation.

Sisi Chen, Rahul S Vedula, Antonio Cuevas-Navarro, Bin Lu, Simon J Hogg, Eric Wang, Salima Benbarche, Katherine Knorr, Won Jun Kim, Robert F Stanley, Hana Cho, Caroline Erickson, Michael Singer, Dan Cui, Steven Tittley, Benjamin H Durham, Tatiana S Pavletich, Elise Fiala, Michael F Walsh, Daichi Inoue, Sebastien Monette, Justin Taylor, Neal Rosen, Frank McCormick, R Coleman Lindsley, Pau Castel, Omar Abdel-Wahab

Cancer Discovery　2022年7月29日　研究論文（学術雑誌）

Dysregulated minor intron splicing in cancer.

Koutarou Nishimura, Hiromi Yamazaki, Weijia Zang, Daichi Inoue

Cancer science　Vol. 113　No. 9　p. 2934-2942　2022年6月29日　研究論文（学術雑誌）

Aberrant EVI1 splicing contributes to EVI1-rearranged leukemia

Atsushi Tanaka, Taizo A Nakano, Masaki Nomura, Hiromi Yamazaki, Jan Philipp Bewersdorf, Roger Mulet-Lazaro, Simon Hogg, Bo Liu, Alex Vincent Penson, Akihiko Yokoyama, Weijia Zang, Marije Havermans, Miho Koizumi, Yasutaka Hayashi, Hana Cho, Akinori Kanai, Stanley C Lee, Muran Xiao, Yui Koike, Yifan Zhang, Miki Fukumoto, Yumi Aoyama, Tsuyoshi Konuma, Hiroyoshi Kunimoto, Toshiya Inaba, Hideaki Nakajima, Hiroaki Honda, Hiroshi Kawamoto, Ruud Delwel, Omar Abdel-Wahab, Daichi Inoue

Blood　Vol. 140　No. 8　p. 875-888　2022年6月16日　研究論文（学術雑誌）

MDS cells impair osteolineage differentiation of MSCs via extracellular vesicles to suppress normal hematopoiesis.

Yasutaka Hayashi, Kimihito C Kawabata, Yosuke Tanaka, Yasufumi Uehara, Yo Mabuchi, Koichi Murakami, Akira Nishiyama, Shigeru Kiryu, Yusuke Yoshioka, Yasunori Ota, Tatsuki Sugiyama, Keiko Mikami, Moe Tamura, Tsuyoshi Fukushima, Shuhei Asada, Reina Takeda, Yuya Kunisaki, Tomofusa Fukuyama, Kazuaki Yokoyama, Tomoyuki Uchida, Masao Hagihara, Nobuhiro Ohno, Kensuke Usuki, Arinobu Tojo, Yoshio Katayama, Susumu Goyama, Fumio Arai, Tomohiko Tamura, Takashi Nagasawa, Takahiro Ochiya, Daichi Inoue, Toshio Kitamura

Cell Reports　Vol. 39　No. 6　p. 110805-110805　2022年5月10日　研究論文（学術雑誌）

Mutant ASXL1 induces age-related expansion of phenotypic hematopoietic stem cells through activation of Akt/mTOR pathway

Takeshi Fujino, Susumu Goyama, Yuki Sugiura, Daichi Inoue, Shuhei Asada, Satoshi Yamasaki, Akiko Matsumoto, Kiyoshi Yamaguchi, Yumiko Isobe, Akiho Tsuchiya, Shiori Shikata, Naru Sato, Hironobu Morinaga, Tomofusa Fukuyama, Yosuke Tanaka, Tsuyoshi Fukushima, Reina Takeda, Keita Yamamoto, Hiroaki Honda, Emi K. Nishimura, Yoichi Furukawa, Tatsuhiro Shibata, Omar Abdel-Wahab, Makoto Suematsu, Toshio Kitamura

Nature Communications　Vol. 12　No. 1　p. 1826-1826　2021年12月　研究論文（学術雑誌）

ASXL1 mutations are associated with distinct epigenomic alterations that lead to sensitivity to venetoclax and azacytidine.

Nora E Rahmani, Nandini Ramachandra, Srabani Sahu, Nadege Gitego, Andrea Lopez, Kith Pradhan, Tushar D Bhagat, Shanisha Gordon-Mitchell, Bianca Rivera Pena, Mohammad Kazemi, Keshav Rao, Orsi Giricz, Shahina Bano Maqbool, Raul Olea, Yongmei Zhao, Jinghang Zhang, Hamid Dolatshad, Vickram Tittrea, Dharamveer Tatwavedi, Shalini Singh, Juseong Lee, Tianyu Sun, Ulrich Steidl, Aditi Shastri, Daichi Inoue, Omar Abdel-Wahab, Andrea Pellagatti, Evripidis Gavathiotis, Jacqueline Boultwood, Amit Verma

Blood cancer journal　Vol. 11　No. 9　p. 157-157　2021年9月21日　研究論文（学術雑誌）

Targeting low-risk myelodysplastic syndrome with novel therapeutic strategies

Gaurang Trivedi, Daichi Inoue, Lingbo Zhang

Trends in Molecular Medicine　Vol. 27　No. 10　p. 990-999　2021年7月　研究論文（学術雑誌）

Minor intron retention drives clonal hematopoietic disorders and diverse cancer predisposition

Daichi Inoue, Jacob T. Polaski, Justin Taylor, Pau Castel, Sisi Chen, Susumu Kobayashi, Simon J. Hogg, Yasutaka Hayashi, Jose Mario Bello Pineda, Ettaib El Marabti, Caroline Erickson, Katherine Knorr, Miki Fukumoto, Hiromi Yamazaki, Atsushi Tanaka, Chie Fukui, Sydney X. Lu, Benjamin H. Durham, Bo Liu, Eric Wang, Sanjoy Mehta, Daniel Zakheim, Ralph Garippa, Alex Penson, Guo-Liang Chew, Frank McCormick, Robert K. Bradley, Omar Abdel-Wahab

Nature Genetics　Vol. 53　No. 5　p. 707-718　2021年5月　研究論文（学術雑誌）

HHEX promotes myeloid transformation in cooperation with mutant ASXL1.

Reina Takeda, Shuhei Asada, Sung-Joon Park, Akihiko Yokoyama, Hans Jiro Becker, Akinori Kanai, Valeria Visconte, Courtney E Hershberger, Yasutaka Hayashi, Taishi Yonezawa, Moe Tamura, Tsuyoshi Fukushima, Yosuke Tanaka, Tomofusa Fukuyama, Akiko Matsumoto, Satoshi Yamasaki, Kenta Nakai, Satoshi Yamazaki, Toshiya Inaba, Tatsuhiro Shibata, Daichi Inoue, Hiroaki Honda, Susumu Goyama, Jaroslaw P Maciejewski, Toshio Kitamura

Blood　Vol. 136　No. 14　p. 1670-1684　2020年6月3日　研究論文（学術雑誌）

[Understanding and therapeutic targeting of aberrant mRNA splicing mechanisms in oncogenesis].

Atsushi Tanaka, Susumu Kobayashi, Muran Xiao, Daichi Inoue

[Rinsho ketsueki] The Japanese journal of clinical hematology　Vol. 61　No. 6　p. 643-650　2020年　研究論文（学術雑誌）

Spliceosomal Disruption of the Non-Canonical SWI/SNF Chromatin Remodeling Complex in SF3B1 Mutant Leukemias

Daichi Inoue, Chew Guo-Liang, Bo Liu, Stanley C Lee, Brittany C Michel, Joey Pangallo, Andrew R D'Avino, Khrystyna North, Lillian E Bitner, Muran Xiao, Susumu Kobayashi, Akihide Yoshimi, Hana Cho, Sydney X Lu, Justin Taylor, Cigall Kadoch, Robert K. Bradley, Omar Abdel-Wahab

Blood　Vol. 134　No. Supplement_1　p. 637-637　2019年11月13日　研究論文（学術雑誌）

Aberrant RNA Splicing Contributes to the Pathogenesis of EVI-Rearranged Myeloid Leukemias

Daichi Inoue, Stanley C Lee, Akihide Yoshimi, Justin Taylor, Lillian E Bitner, Atsushi Tanaka, Yasutaka Hayashi, Hana Cho, Chie Fukui, Ruth Saganty, Alexander V Penson, Omar Abdel-Wahab

Blood　Vol. 134　No. Supplement_1　p. 917-917　2019年11月13日　研究論文（学術雑誌）

Mutant ASXL1 Promotes Expansion of the Phenotypic Hematopoietic Stem Cell Compartment

Takeshi Fujino, Susumu Goyama, Yuki Sugiura, Daichi Inoue, Satoshi Yamasaki, Akiko Matsumoto, Naru Sato, Hironobu Morinaga, Shiori Shikata, Tomofusa Fukuyama, Yosuke Tanaka, Shuhei Asada, Tsuyoshi Fukushima, Hiroaki Honda, Emi K Nishimura, Tatsuhiro Shibata, Makoto Suematsu, Toshio Kitamura

Blood　Vol. 134　No. Supplement_1　p. 821-821　2019年11月13日　研究論文（学術雑誌）

Altered Nuclear Export Signal Recognition as a Driver of Oncogenesis.

Justin Taylor, Maria Sendino, Alexander N Gorelick, Alessandro Pastore, Matthew T Chang, Alexander V Penson, Elena I Gavrila, Connor Stewart, Ella M Melnik, Florisela Herrejon Chavez, Lillian Bitner, Akihide Yoshimi, Stanley Chun-Wei Lee, Daichi Inoue, Bo Liu, Xiao J Zhang, Anthony R Mato, Ahmet Dogan, Michael G Kharas, Yuhong Chen, Demin Wang, Rajesh K Soni, Ronald C Hendrickson, Gorka Prieto, Jose A Rodriguez, Barry S Taylor, Omar Abdel-Wahab

Cancer Discovery　Vol. 9　No. 10　p. 1452-1467　2019年10月　研究論文（学術雑誌）

Coordinated alterations in RNA splicing and epigenetic regulation drive leukaemogenesis.

Akihide Yoshimi, Kuan-Ting Lin, Daniel H Wiseman, Mohammad Alinoor Rahman, Alessandro Pastore, Bo Wang, Stanley Chun-Wei Lee, Jean-Baptiste Micol, Xiao Jing Zhang, Stephane de Botton, Virginie Penard-Lacronique, Eytan M Stein, Hana Cho, Rachel E Miles, Daichi Inoue, Todd R Albrecht, Tim C P Somervaille, Kiran Batta, Fabio Amaral, Fabrizio Simeoni, Deepti P Wilks, Catherine Cargo, Andrew M Intlekofer, Ross L Levine, Heidi Dvinge, Robert K Bradley, Eric J Wagner, Adrian R Krainer, Omar Abdel-Wahab

Nature　Vol. 574　No. 7777　p. 273-277　2019年10月　研究論文（学術雑誌）

Spliceosomal disruption of the non-canonical BAF complex in cancer.

Daichi Inoue, Guo-Liang Chew, Bo Liu, Brittany C Michel, Joseph Pangallo, Andrew R D'Avino, Tyler Hitchman, Khrystyna North, Stanley Chun-Wei Lee, Lillian Bitner, Ariele Block, Amanda R Moore, Akihide Yoshimi, Luisa Escobar-Hoyos, Hana Cho, Alex Penson, Sydney X Lu, Justin Taylor, Yu Chen, Cigall Kadoch, Omar Abdel-Wahab, Robert K Bradley

Nature　Vol. 574　No. 7778　p. 432-436　2019年10月　研究論文（学術雑誌）

Muscarinic acetylcholine receptor regulates self-renewal of early erythroid progenitors.

Trivedi G, Inoue D, Chen C, Bitner L, Chung YR, Taylor J, Abdel-Wahab O, Zhang L

Sci Transl Med　Vol. 11　No. 511　2019年9月25日　研究論文（学術雑誌）

Myelodysplastic/myeloproliferative neoplasm with ring sideroblasts and thrombocytosis (MDS/MPN with RS-T) complicated by hyperleukocytosis and gene analysis in relation to leukocytosis.

Yumi Aoyama, Kazuko Sakai, Taiichi Kodaka, Hiroko Tsunemine, Kazuto Nishio, Tomoo Itoh, Daichi Inoue, Takayuki Takahashi

Journal of clinical and experimental hematopathology : JCEH　Vol. 59　No. 1　p. 29-33　2019年3月27日　研究論文（学術雑誌）

Targeting an RNA-Binding Protein Network in Acute Myeloid Leukemia.

Eric Wang, Sydney X Lu, Alessandro Pastore, Xufeng Chen, Jochen Imig, Stanley Chun-Wei Lee, Kathryn Hockemeyer, Yohana E Ghebrechristos, Akihide Yoshimi, Daichi Inoue, Michelle Ki, Hana Cho, Lillian Bitner, Andreas Kloetgen, Kuan-Ting Lin, Taisuke Uehara, Takashi Owa, Raoul Tibes, Adrian R Krainer, Omar Abdel-Wahab, Iannis Aifantis

Cancer Cell　Vol. 35　No. 3　p. 369-384　2019年3月18日　研究論文（学術雑誌）

ASXL1 and SETBP1 mutations promote leukaemogenesis by repressing TGFβ pathway genes through histone deacetylation

Saika M, Inoue D, Nagase R, Sato N, Tsuchiya A, Yabushita T, Kitamura T, Goyama S

Sci Rep　Vol. 8　No. 1　p. 15873-15873　2018年10月26日　研究論文（学術雑誌）

ASXL1 as a critical regulator of epigenetic marks and therapeutic potential of mutated cells.

Daichi Inoue, Takeshi Fujino, Toshio Kitamura

Oncotarget　Vol. 9　No. 81　p. 35203-35204　2018年10月16日

ASXL1変異は造血幹・前駆細胞におけるミトコンドリアの機能亢進とDNA損傷を惹起する(Mutant ASXL1 induces mitochondrial dysregulation and ROS-mediated DNA damage in haematopoietic cells)

藤野 赳至, 合山 進, 杉浦 悠毅, 井上 大地, 山崎 智, 松本 明子, 佐藤 成, 森永 浩伸, 四方 紫織, 永瀬 玲奈, 福山 朋房, 田中 洋介, 浅田 修平, 福島 剛, 本田 浩章, 西村 栄美, 柴田 龍弘, Abdel-Wahab Omar, 末松 誠, 北村 俊雄

臨床血液　Vol. 59　No. 9　p. 1518-1518　2018年9月

Oncogenic TRK fusions are amenable to inhibition in hematologic malignancies.

Justin Taylor, Dean Pavlick, Akihide Yoshimi, Christina Marcelus, Stephen S Chung, Jaclyn F Hechtman, Ryma Benayed, Emiliano Cocco, Benjamin H Durham, Lillian Bitner, Daichi Inoue, Young Rock Chung, Kerry Mullaney, Justin M Watts, Eli L Diamond, Lee A Albacker, Tariq I Mughal, Kevin Ebata, Brian B Tuch, Nora Ku, Maurizio Scaltriti, Mikhail Roshal, Maria Arcila, Siraj Ali, David M Hyman, Jae H Park, Omar Abdel-Wahab

The Journal of clinical investigation　Vol. 128　No. 9　p. 3819-3825　2018年8月31日　研究論文（学術雑誌）

Synthetic Lethal and Convergent Biological Effects of Cancer-Associated Spliceosomal Gene Mutations.

Stanley Chun-Wei Lee, Khrystyna North, Eunhee Kim, Eunjung Jang, Esther Obeng, Sydney X Lu, Bo Liu, Daichi Inoue, Akihide Yoshimi, Michelle Ki, Mirae Yeo, Xiao Jing Zhang, Min Kyung Kim, Hana Cho, Young Rock Chung, Justin Taylor, Benjamin H Durham, Young Joon Kim, Alessandro Pastore, Sebastien Monette, James Palacino, Michael Seiler, Silvia Buonamici, Peter G Smith, Benjamin L Ebert, Robert K Bradley, Omar Abdel-Wahab

Cancer Cell　Vol. 34　No. 2　p. 225-241　2018年8月13日　研究論文（学術雑誌）

Mutant ASXL1 cooperates with BAP1 to promote myeloid leukaemogenesis.

Shuhei Asada, Susumu Goyama, Daichi Inoue, Shiori Shikata, Reina Takeda, Tsuyoshi Fukushima, Taishi Yonezawa, Takeshi Fujino, Yasutaka Hayashi, Kimihito Cojin Kawabata, Tomofusa Fukuyama, Yosuke Tanaka, Akihiko Yokoyama, Satoshi Yamazaki, Hiroko Kozuka-Hata, Masaaki Oyama, Shinya Kojima, Masahito Kawazu, Hiroyuki Mano, Toshio Kitamura

Nature Communications　Vol. 9　No. 1　p. 2733-2733　2018年7月16日　研究論文（学術雑誌）

Expression of mutant Asxl1 perturbs hematopoiesis and promotes susceptibility to leukemic transformation.

Reina Nagase, Daichi Inoue, Alessandro Pastore, Takeshi Fujino, Hsin-An Hou, Norimasa Yamasaki, Susumu Goyama, Makoto Saika, Akinori Kanai, Yasuyuki Sera, Sayuri Horikawa, Yasunori Ota, Shuhei Asada, Yasutaka Hayashi, Kimihito Cojin Kawabata, Reina Takeda, Hwei-Fang Tien, Hiroaki Honda, Omar Abdel-Wahab, Toshio Kitamura

The Journal of experimental medicine　Vol. 215　No. 6　p. 1729-1747　2018年6月4日　研究論文（学術雑誌）

A novel ASXL1-OGT axis plays roles in H3K4 methylation and tumor suppression in myeloid malignancies.

Daichi Inoue, Takeshi Fujino, Paul Sheridan, Yao-Zhong Zhang, Reina Nagase, Sayuri Horikawa, Zaomin Li, Hirotaka Matsui, Akinori Kanai, Makoto Saika, Rui Yamaguchi, Hiroko Kozuka-Hata, Kimihito Cojin Kawabata, Akihiko Yokoyama, Susumu Goyama, Toshiya Inaba, Seiya Imoto, Satoru Miyano, Mingjiang Xu, Feng-Chun Yang, Masaaki Oyama, Toshio Kitamura

Leukemia　Vol. 32　No. 6　p. 1327-1337　2018年6月　研究論文（学術雑誌）

High expression of ABCG2 induced by EZH2 disruption plays pivotal roles in MDS pathogenesis.

Kawabata KC, Hayashi Y, Inoue D, Meguro H, Sakurai H, Fukuyama T, Tanaka Y, Asada S, Fukushima T, Nagase R, Takeda R, Harada Y, Kitaura J, Goyama S, Harada H, Aburatani H, Kitamura T

Leukemia　Vol. 32　No. 2　p. 419-428　2018年　研究論文（学術雑誌）

ASXL2 is essential for haematopoiesis and acts as a haploinsufficient tumour suppressor in leukemia.

Jean-Baptiste Micol, Alessandro Pastore, Daichi Inoue, Nicolas Duployez, Eunhee Kim, Stanley Chun-Wei Lee, Benjamin H Durham, Young Rock Chung, Hana Cho, Xiao Jing Zhang, Akihide Yoshimi, Andrei Krivtsov, Richard Koche, Eric Solary, Amit Sinha, Claude Preudhomme, Omar Abdel-Wahab

Nature communications　Vol. 8　p. 15429-15429　2017年5月18日　研究論文（学術雑誌）

Modeling SF3B1 Mutations in Cancer: Advances, Challenges, and Opportunities.

Inoue D, Abdel-Wahab O

Cancer Cell　Vol. 30　No. 3　p. 371-373　2016年9月12日

Biological implications of somatic DDX41 p.R525H mutation in acute myeloid leukemia.

Kadono M, Kanai A, Nagamachi A, Shinriki S, Kawata J, Iwato K, Kyo T, Oshima K, Yokoyama A, Kawamura T, Nagase R, Inoue D, Kitamura T, Inaba T, Ichinohe T, Matsui H

Exp Hematol　Vol. 44　No. 8　p. 745-754　2016年8月　研究論文（学術雑誌）

Spliceosomal gene mutations in myelodysplasia: molecular links to clonal abnormalities of hematopoiesis.

Inoue D, Bradley RK, Abdel-Wahab O

Genes Dev　Vol. 30　No. 9　p. 989-1001　2016年5月1日

Truncation mutants of ASXL1 observed in myeloid malignancies are expressed at detectable protein levels.

Inoue D, Matsumoto M, Nagase R, Saika M, Fujino T, Nakayama KI, Kitamura T

Exp Hematol　Vol. 44　No. 3　p. 172-6　2016年3月

Novel working hypothesis for pathogenesis of hematological malignancies: combination of mutations-induced cellular phenotypes determines the disease (cMIP-DD).

Toshio Kitamura, Naoko Watanabe-Okochi, Yutaka Enomoto, Fumio Nakahara, Toshihiko Oki, Yukiko Komeno, Naoko Kato, Noriko Doki, Tomoyuki Uchida, Yuki Kagiyama, Katsuhiro Togami, Kimihito C Kawabata, Koutarou Nishimura, Yasutaka Hayashi, Reina Nagase, Makoto Saika, Tsuyoshi Fukushima, Shuhei Asada, Takeshi Fujino, Yuto Izawa, Sayuri Horikawa, Tomofusa Fukuyama, Yosuke Tanaka, Ryoichi Ono, Susumu Goyama, Tetsuya Nosaka, Jiro Kitaura, Daichi Inoue

Journal of biochemistry　Vol. 159　No. 1　p. 17-25　2016年1月　研究論文（学術雑誌）

THE STABILITY OF EPIGENETIC FACTOR ASXL1 IS REGULATED THROUGH UBIQUITINATION AND USP7-MEDIATED DEUBIQUITINATION

D. Inoue, R. Nagase, M. Saika, K. Nishimura, M. Oyama, T. Kitamura

LEUKEMIA RESEARCH　Vol. 39　p. S71-S71　2015年4月

SETBP1 mutations drive leukemic transformation in ASXL1-mutated MDS

D. Inoue, J. Kitaura, H. Matsui, H-A Hou, W-C Chou, A. Nagamachi, K. C. Kawabata, K. Togami, R. Nagase, S. Horikawa, M. Saika, J-B Micol, Y. Hayashi, Y. Harada, H. Harada, T. Inaba, H-F Tien, O. Abdel-Wahab, T. Kitamura

LEUKEMIA　Vol. 29　No. 4　p. 847-857　2015年4月　研究論文（学術雑誌）

A C-terminal mutant of C/EBPα (C/EBPα-Cm) down-regulates Csf1r, a potent accelerator in the progression of AML with C/EBPα-Cm.

Togami K, Kitaura J, Uchida T, Inoue D, Nishimura K, Kawabata KC, Nagase R, Horikawa S, Izawa K, Fukuyama T, Nakahara F, Oki T, Harada Y, Harada H, Aburatani H, Kitamura T

Exp Hematol　Vol. 43　No. 4　p. 300-8　2015年4月　研究論文（学術雑誌）

[Molecular basis of hematological malignancies].

Toshio Kitamura, Daichi Inoue, Fumio Nakahara, Naoko Okochi, Naoko Kato, Katsuhiro Togami, Tomoyuki Uchida, Yuki Kagiyama, Kimihito Cojin Kawabata, Reina Nagase, Sayuri Horikawa, Kouki Hayashi, Makoto Saika, Kumi Izawa, Toshihiko Oki, Shigeru Chiba, Yuka Harada, Hironori Harada, Jiro Kitaura

[Rinsho ketsueki] The Japanese journal of clinical hematology　Vol. 55　No. 10　p. 1715-23　2014年10月　研究論文（学術雑誌）

Hes1 promotes blast crisis in chronic myelogenous leukemia through MMP-9 upregulation in leukemic cells.

Nakahara F, Kitaura J, Uchida T, Nishida C, Togami K, Inoue D, Matsukawa T, Kagiyama Y, Enomoto Y, Kawabata K, Lai CY, Komeno Y, Izawa K, Oki T, Nagae G, Harada Y, Harada H, Otsu M, Aburatani H, Heissig B, Hattori K, Kitamura T

Blood　Vol. 123　No. 25　p. 3932-42　2014年6月19日　研究論文（学術雑誌）

Hes1 up-regulation contributes to the development of FIP1L1-PDGFRA-positive leukemia in blast crisis.

Uchida T, Kitaura J, Nakahara F, Togami K, Inoue D, Maehara A, Nishimura K, Kawabata KC, Doki N, Kakihana K, Yoshioka K, Izawa K, Oki T, Sada A, Harada Y, Ohashi K, Katayama Y, Matsui T, Harada H, Kitamura T

Exp Hematol　Vol. 42　No. 5　p. 369-379　2014年5月　研究論文（学術雑誌）

IP-10/CXCL10 and MIG/CXCL9 as novel markers for the diagnosis of lymphoma-associated hemophagocytic syndrome.

Hayato Maruoka, Daichi Inoue, Yoko Takiuchi, Seiji Nagano, Hiroshi Arima, Sumie Tabata, Akiko Matsushita, Takayuki Ishikawa, Tatsuo Oita, Takayuki Takahashi

Annals of hematology　Vol. 93　No. 3　p. 393-401　2014年3月　研究論文（学術雑誌）

The molecular basis of myeloid malignancies.

Kitamura T, Inoue D, Okochi-Watanabe N, Kato N, Komeno Y, Lu Y, Enomoto Y, Doki N, Uchida T, Kagiyama Y, Togami K, Kawabata KC, Nagase R, Horikawa S, Hayashi Y, Saika M, Fukuyama T, Izawa K, Oki T, Nakahara F, Kitaura J

Proc Jpn Acad Ser B Phys Biol Sci　Vol. 90　No. 10　p. 389-404　2014年　研究論文（学術雑誌）

Simultaneous thrombosis of the mesenteric artery and vein as a novel clinical manifestation of intravascular large B-cell lymphoma.

Arima H, Inoue D, Tabata S, Matsushita A, Imai Y, Ishikawa T, Takahashi T

Acta Haematol　Vol. 132　No. 1　p. 108-11　2014年　研究論文（学術雑誌）

Myelodysplastic syndromes are induced by histone methylation–altering ASXL1 mutations.

Inoue D, Kitaura J, Togami K, Nishimura K, Enomoto Y, Uchida T, Kagiyama Y, Kawabata KC, Nakahara F, Izawa K, Oki T, Maehara A, Isobe M, Tsuchiya A, Harada Y, Harada H, Ochiya T, Aburatani H, Kimura H, Thol F, Heuser M, Levine RL, Abdel-Wahab O, Kitamura T

J Clin Invest　Vol. 123　No. 11　p. 4627-40　2013年11月　研究論文（学術雑誌）

RUNX1/AML1 mutant collaborates with BMI1 overexpression in the development of human and murine myelodysplastic syndromes.

Harada Y, Inoue D, co-first, auth, Ding Y, Imagawa J, Doki N, Matsui H, Yahata T, Matsushita H, Ando K, Sashida G, Iwama A, Kitamura T, Harada H

Blood　Vol. 121　No. 17　p. 3434-46　2013年4月25日　研究論文（学術雑誌）

Upregulation of CD200R1 in lineage-negative leukemic cells is characteristic of AML1-ETO-positive leukemia in mice.

Kagiyama Y, Kitaura J, Togami K, Uchida T, Inoue D, Matsukawa T, Izawa K, Kawabata KC, Komeno Y, Oki T, Nakahara F, Sato K, Aburatani H, Kitamura T

Int J Hematol　Vol. 96　No. 5　p. 638-48　2012年11月　研究論文（学術雑誌）

HDACI-induced thrombocytopenia is caused by its unexpected target.

Kitamura T, Inoue D

Exp Hematol　Vol. 40　No. 9　p. 695-7　2012年9月

[Molecular mechanisms underlying leukemic transformation of myelodysplastic syndromes (MDS) and chronic myelogenous leukemia (CML)].

Toshio Kitamura, Naoko Watanabe-Okochi, Daichi Inoue, Katsuhiro Togami, Tomoyuki Uchida, Yuuki Kagiyama, Kimihito Kawabata, Shigeru Chiba, Yuka Harada, Hironori Harada, Jiro Kitaura, Fumio Nakahara

[Rinsho ketsueki] The Japanese journal of clinical hematology　Vol. 53　No. 8　p. 734-9　2012年8月　研究論文（学術雑誌）

A novel clinical entity, IgG4-related disease (IgG4RD): general concept and details

Hisanori Umehara, Kazuichi Okazaki, Yasufumi Masaki, Mitsuhiro Kawano, Motohisa Yamamoto, Takako Saeki, Shoko Matsui, Takayuki Sumida, Tsuneyo Mimori, Yoshiya Tanaka, Kazuo Tsubota, Tadashi Yoshino, Shigeyuki Kawa, Ritsuro Suzuki, Tsutomu Takegami, Naohisa Tomosugi, Nozomu Kurose, Yasuhito Ishigaki, Atsushi Azumi, Masaru Kojima, Shigeo Nakamura, Dai Inoue

MODERN RHEUMATOLOGY　Vol. 22　No. 1　p. 1-14　2012年2月

Fyn is not essential for Bcr-Abl-induced leukemogenesis in mouse bone marrow transplantation models.

Doki N, Kitaura J, Uchida T, Inoue D, Kagiyama Y, Togami K, Isobe M, Ito S, Maehara A, Izawa K, Kato N, Oki T, Harada Y, Nakahara F, Harada H, Kitamura T

Int J Hematol　Vol. 95　No. 2　p. 167-75　2012年2月　研究論文（学術雑誌）

Bacillus cereus Sepsis in the Treatment of Acute Myeloid Leukemia.

Inoue D, Takahashi T

Myeloid Leukemia　2012年

Successful treatment of γ-heavy-chain disease with rituximab and fludarabine.

Inoue D, Matsushita A, Kiuchi M, Takiuchi Y, Nagano S, Arima H, Mori M, Tabata S, Yamashiro A, Maruoka H, Oita T, Imai Y, Takahashi T

Acta Haematol　Vol. 128　No. 3　p. 139-43　2012年　研究論文（学術雑誌）

Leukemic manifestation of blastic plasmacytoid dendritic cell neoplasm lacking skin lesion : a borderline case between acute monocytic leukemia.

Yoko Takiuchi, Hayato Maruoka, Kazunari Aoki, Aiko Kato, Yuichiro Ono, Seiji Nagano, Hiroshi Arima, Daichi Inoue, Minako Mori, Sumie Tabata, Soshi Yanagita, Akiko Matsushita, Mari Nishio, Yukihiro Imai, Yukihiro Imai, Kiminari Ito, Haruyuki Fujita, Norimitsu Kadowaki, Takayuki Ishikawa, Takayuki Takahashi

Journal of clinical and experimental hematopathology : JCEH　Vol. 52　No. 2　p. 107-11　2012年　研究論文（学術雑誌）

[Exacerbation of autoimmune neutropenia to agranulocytosis in association with severe autoimmune thrombocytopenia and hemolytic anemia in a patient with Sjögren's syndrome].

Sonoko Shimoji, Yohko Takiuchi, Hayato Maruoka, Daichi Inoue, Takaharu Kimura, Minako Mori, Yuya Nagai, Katuhiro Togami, Sumie Tabata, Masayuki Kurata, Akiko Matsushita, Kenichi Nagai, Takayuki Takahashi

[Rinsho ketsueki] The Japanese journal of clinical hematology　Vol. 52　No. 7　p. 535-9　2011年7月

Blastic plasmacytoid dendritic cell neoplasm expressing the CD13 myeloid antigen.

Daichi Inoue, Kyoko Maruyama, Kazunari Aoki, Seiji Nagano, Hayato Maruoka, Yukihiro Imai, Kiminari Ito, Takayuki Ishikawa, Takayuki Takahashi

Acta Haematologica　Vol. 126　No. 2　p. 122-8　2011年　研究論文（学術雑誌）

Excellent therapeutic effect of tocilizumab on intestinal amyloid a deposition secondary to active rheumatoid arthritis.

Daichi Inoue, Hiroshi Arima, Chiharu Kawanami, Yoko Takiuchi, Seiji Nagano, Takaharu Kimura, Sonoko Shimoji, Minako Mori, Sumie Tabata, Soshi Yanagita, Akiko Matsushita, Kenichi Nagai, Yukihiro Imai, Takayuki Takahashi

Clinical Rheumatology　Vol. 29　No. 10　p. 1195-7　2010年10月　研究論文（学術雑誌）

MOLECULAR BASIS FOR AML, MDS AND MPN

T. Kitamura, F. Nakahara, N. Kato, N. Watanabe-Okochi, Y. Komeno, N. Doki, K. Togami, T. Uchida, Y. Kagiyama, D. Inoue, Y. Enomoto, T. Oki, H. Harada, S. Chiba, J. Kitaura

EXPERIMENTAL HEMATOLOGY　Vol. 38　No. 9　p. S107-S108　2010年9月　研究論文（国際会議プロシーディングス）

Clinical analysis and optimization of postremission therapy for acute myeloid leukemia patients with minimal residual disease as determined by flow cytometry.

Inoue D, Maruoka H, Takahashi T

Mediterr J Hematol Infect Dis.　Vol. 2　No. 2　2010年8月5日

Histiocytic sarcoma and underlying chronic myelomonocytic leukemia: a proposal for the developmental classification of histiocytic sarcoma.

Minako Mori, Akiko Matsushita, Yohko Takiuchi, Hiroshi Arima, Seiji Nagano, Sonoko Shimoji, Takaharu Kimura, Daichi Inoue, Sumie Tabata, Sohshi Yanagita, Kenichi Nagai, Yukihiro Imai, Takayuki Takahashi

International journal of hematology　Vol. 92　No. 1　p. 168-73　2010年7月　研究論文（学術雑誌）

[Graft-versus-leukemia effect by lymphocytes from the first donor after second cord blood transplantation in a patient with T-lymphoblastic lymphoma].

Kenichi Nagai, Hisako Hashimoto, Kiminari Itoh, Akiko Matsushita, Sonoko Shimoji, Takaharu Kimura, Daichi Inoue, Minako Mori, Yuya Nagai, Sumie Tabata, Muneyuki Yanagida, Takayuki Takahashi

[Rinsho ketsueki] The Japanese journal of clinical hematology　Vol. 51　No. 6　p. 413-21　2010年6月

治療抵抗性血管免疫芽球性T細胞性リンパ腫に対するCyclosporin Aの有用性

森 美奈子, 井上 大地, 有馬 浩史, 瀧内 曜子, 永野 誠治, 木村 隆治, 下地 園子, 永井 雄也, 田端 淑恵, 柳田 宗之, 松下 章子, 永井 謙一, 今井 幸弘, 高橋 隆幸

臨床血液　Vol. 51　No. 5　p. 332-338　2010年5月

[Therapeutic efficacy of cyclosporin A for refractory angioimmunoblastic T cell lymphoma].

Minako Mori, Daichi Inoue, Hiroshi Arima, Yohko Takiuchi, Seiji Nagano, Takaharu Kimura, Sonoko Shimoji, Yuya Nagai, Sumie Tabata, Sohshi Yanagita, Akiko Matsushita, Kenichi Nagai, Yukihiro Imai, Takayuki Takahashi

[Rinsho ketsueki] The Japanese journal of clinical hematology　Vol. 51　No. 5　p. 332-8　2010年5月　研究論文（学術雑誌）

Fulminant sepsis caused by Bacillus cereus in patients with hematologic malignancies: analysis of its prognosis and risk factors.

Daichi Inoue, Yuya Nagai, Minako Mori, Seiji Nagano, Yoko Takiuchi, Hiroshi Arima, Takaharu Kimura, Sonoko Shimoji, Katsuhiro Togami, Sumie Tabata, Soshi Yanagita, Akiko Matsushita, Kenichi Nagai, Yukihiro Imai, Hiroshi Takegawa, Takayuki Takahashi

Leukemia & Lymphoma　Vol. 51　No. 5　p. 860-9　2010年5月　研究論文（学術雑誌）

Successful living donor liver transplantation for severe hepatic GVHD histologically resembling autoimmune hepatitis after bone marrow transplantation from the same sibling donor.

Mori M, Matsushita A, Takiuchi Y, Arima H, Nagano S, Shimoji S, Kimura T, Inoue D, Tabata S, Yanagita S, Nagai K, Imai Y, Takahashi T

Transpl Int　Vol. 23　No. 5　2010年5月1日

Successful Treatment of Extranodal Natural Killer/T-cell Lymphoma, Nasal Type, Complicated by Severe Hemophagocytic Syndrome with SMILE Chemotherapy Followed by Autologous Stem Cell Transplantation.

Inoue D, Nagai Y, Takiuchi Y, Nagano S, Arima H, Kimura T, Shimoji S, Mori M, Togami K, Tabata S, Yanagita S, Matsushita A, Nagai K, Maruoka H, Imai Y, Suzuki R, Takahashi T

Leuk Lymphoma　Vol. 51　No. 4　p. 720-3　2010年4月

Hepatosplenic alphabeta T cell lymphoma.

Nagai Y, Ikegame K, Mori M, Inoue D, Kimura T, Shimoji S, Togami K, Tabata S, Kurata M, Imai Y, Matsushita A, Nagai K, Ogawa H, Takahashi T

Int J Clin Oncol　Vol. 15　No. 2　p. 215-9　2010年4月

[Early diagnosis and successful treatment of catastrophic antiphospholipid syndrome complicated by multiple organ failure].

Daichi Inoue, Katsuhiro Togami, Norihiro Shimoike, Ryo Tamura, Yukihiro Imai, Takaharu Kimura, Sonoko Shimoji, Minako Mori, Yuya Nagai, Sumie Tabata, Akiko Matsushita, Kenichi Nagai, Takayuki Takahashi

Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology　Vol. 33　No. 1　p. 24-30　2010年

Successful Treatment of POEMS Syndrome Complicated by Severe Congestive Heart Failure with Thalidomide.

Inoue D, Kato A, Tabata S, Kitai T, Takiuchi Y, Kimura T, Shimoji S, Mori M, Nagai Y, Togami K, Matsushita A, Nagai K, Maruoka H, Imai Y, Beppu M, Kawamoto M, Takahashi T

Internal Med　Vol. 49　No. 5　p. 461-6　2010年

Successful allogeneic bone marrow transplantation for diamond-blackfan anemia complicated by severe cardiac dysfunction due to transfusion-induced hemochromatosis.

Sumie Tabata, Minako Mori, Yuya Nagai, Hisako Hashimoto, Hiroshi Arima, Seiji Nagano, Yoko Takiuchi, Daichi Inoue, Takaharu Kimura, Sonoko Shimoji, Soshi Yanagita, Kiminari Ito, Akiko Matsushita, Kenichi Nagai, Takayuki Takahashi

Internal medicine (Tokyo, Japan)　Vol. 49　No. 5　p. 453-6　2010年　研究論文（学術雑誌）

[Successful treatment of chronic disseminated intravascular coagulation syndrome with continuous subcutaneous infusion of heparin using a mobile infusion pump: report of 2 cases].

Katsuhiro Togami, Yuya Nagai, Hiroshi Arima, Sonoko Shimoji, Takahiro Kimura, Daichi Inoue, Minako Mori, Haruyuki Fujita, Sumie Tabata, Masayuki Kurata, Soshi Yanagida, Akiko Matsushita, Kenichi Nagai, Shuichiroh Kaji, Takayuki Takahashi

[Rinsho ketsueki] The Japanese journal of clinical hematology　Vol. 50　No. 12　p. 1700-5　2009年12月　研究論文（学術雑誌）

Successful treatment with autologous peripheral blood stem cell transplantation for acquired immunodeficiency syndrome (AIDS)-related malignant lymphoma.

Yuya NAGAI, Minako MORI, Daichi INOUE, Takaharu KIMURA, Sonoko SHIMOJI, Katsuhiro TOGAMI, Sumie TABATA, Akiko MATSUSHITA, Kenichi NAGAI, Yukihiro Imai, Toshiro Takafuta, Takayuki Takahashi

[Rinsho ketsueki] The Japanese journal of clinical hematology　Vol. 50　No. 11　p. 1641-6　2009年11月

Successful allogeneic bone marrow transplantation for myelodysplastic syndrome complicated by severe pulmonary alveolar proteinosis.

Int J Hematol　Vol. 90　No. 3　p. 407-412　2009年10月　研究論文（学術雑誌）

Refractory de novo myeloid sarcoma: a case report and therapeutic strategy based on bone marrow minimal residual disease.

Inoue D, Nagai Y, Kimura T, Shimoji S, Mori M, Togami K, Tabata S, Kurata M, Matsushita A, Ito K, Hashimoto H, Maruoka H, Yamashita E, Nagai K, Imai Y, Shirane H, Takahashi T

Int J Hematol　Vol. 90　No. 1　p. 120-123　2009年7月

[Angioimmunoblastic T-cell lymphoma complicated by recurrent drug-induced agranulocytosis].

Daichi Inoue, Takaharu Kimura, Sonoko Shimoji, Minako Mori, Yuya Nagai, Sumie Tabata, Masayuki Kurata, Akiko Matsushita, Kenichi Nagai, Hayato Maruoka, Eiko Yamashita, Takayuki Takahashi

[Rinsho ketsueki] The Japanese journal of clinical hematology　Vol. 50　No. 2　p. 87-91　2009年2月