Systematic evaluation of AML-associated antigens identifies anti-U5 SNRNP200 therapeutic antibodies for the treatment of acute myeloid leukemia

Katherine Knorr, Jahan Rahman, Caroline Erickson, Eric Wang, Mara Monetti, Zhuoning Li, Juliana Ortiz-Pacheco, Andrew Jones, Sydney X. Lu, Robert F. Stanley, Maria Baez, Nina Fox, Cynthia Castro, Alessandra E. Marino, Caroline Jiang, Alex Penson, Simon J. Hogg, Xiaoli Mi, Hideaki Nakajima, Hiroyoshi Kunimoto, Koutarou Nishimura, Daichi Inoue, Benjamin Greenbaum, David Knorr, Jeffrey Ravetch, Omar Abdel-Wahab

Nature Cancer　2023/10/23　Research paper (scientific journal)

SETBP1 is dispensable for normal and malignant hematopoiesis.

Atsushi Tanaka, Koutarou Nishimura, Wataru Saika, Ayana Kon, Yui Koike, Hiromi Tatsumi, June Takeda, Masaki Nomura, Weijia Zang, Manabu Nakayama, Masashi Matsuda, Hiromi Yamazaki, Miki Fukumoto, Hiromi Ito, Yasutaka Hayashi, Toshio Kitamura, Hiroshi Kawamoto, Akifumi Takaori-Kondo, Haruhiko Koseki, Seishi Ogawa, Daichi Inoue

Leukemia　2023/07/18　Research paper (scientific journal)

Extracellular vesicle-mediated remodeling of the bone marrow microenvironment in myeloid malignancies.

Yasutaka Hayashi, Koutarou Nishimura, Atsushi Tanaka, Daichi Inoue

International journal of hematology　2023/04/12　Research paper (scientific journal)

Exploring the mechanistic link between SF3B1 mutation and ring sideroblast formation in myelodysplastic syndrome.

Tetsuro Ochi, Tohru Fujiwara, Koya Ono, Chie Suzuki, Maika Nikaido, Daichi Inoue, Hiroki Kato, Koichi Onodera, Satoshi Ichikawa, Noriko Fukuhara, Yasushi Onishi, Hisayuki Yokoyama, Yukio Nakamura, Hideo Harigae

Scientific Reports　Vol. 12　No. 1　p. 14562-14562　2022/08/26　Research paper (scientific journal)

Impaired proteolysis of non-canonical RAS proteins drives clonal hematopoietic transformation.

Sisi Chen, Rahul S Vedula, Antonio Cuevas-Navarro, Bin Lu, Simon J Hogg, Eric Wang, Salima Benbarche, Katherine Knorr, Won Jun Kim, Robert F Stanley, Hana Cho, Caroline Erickson, Michael Singer, Dan Cui, Steven Tittley, Benjamin H Durham, Tatiana S Pavletich, Elise Fiala, Michael F Walsh, Daichi Inoue, Sebastien Monette, Justin Taylor, Neal Rosen, Frank McCormick, R Coleman Lindsley, Pau Castel, Omar Abdel-Wahab

Cancer Discovery　2022/07/29　Research paper (scientific journal)

Dysregulated minor intron splicing in cancer.

Koutarou Nishimura, Hiromi Yamazaki, Weijia Zang, Daichi Inoue

Cancer science　Vol. 113　No. 9　p. 2934-2942　2022/06/29　Research paper (scientific journal)

Aberrant EVI1 splicing contributes to EVI1-rearranged leukemia

Atsushi Tanaka, Taizo A Nakano, Masaki Nomura, Hiromi Yamazaki, Jan Philipp Bewersdorf, Roger Mulet-Lazaro, Simon Hogg, Bo Liu, Alex Vincent Penson, Akihiko Yokoyama, Weijia Zang, Marije Havermans, Miho Koizumi, Yasutaka Hayashi, Hana Cho, Akinori Kanai, Stanley C Lee, Muran Xiao, Yui Koike, Yifan Zhang, Miki Fukumoto, Yumi Aoyama, Tsuyoshi Konuma, Hiroyoshi Kunimoto, Toshiya Inaba, Hideaki Nakajima, Hiroaki Honda, Hiroshi Kawamoto, Ruud Delwel, Omar Abdel-Wahab, Daichi Inoue

Blood　Vol. 140　No. 8　p. 875-888　2022/06/16　Research paper (scientific journal)

MDS cells impair osteolineage differentiation of MSCs via extracellular vesicles to suppress normal hematopoiesis.

Yasutaka Hayashi, Kimihito C Kawabata, Yosuke Tanaka, Yasufumi Uehara, Yo Mabuchi, Koichi Murakami, Akira Nishiyama, Shigeru Kiryu, Yusuke Yoshioka, Yasunori Ota, Tatsuki Sugiyama, Keiko Mikami, Moe Tamura, Tsuyoshi Fukushima, Shuhei Asada, Reina Takeda, Yuya Kunisaki, Tomofusa Fukuyama, Kazuaki Yokoyama, Tomoyuki Uchida, Masao Hagihara, Nobuhiro Ohno, Kensuke Usuki, Arinobu Tojo, Yoshio Katayama, Susumu Goyama, Fumio Arai, Tomohiko Tamura, Takashi Nagasawa, Takahiro Ochiya, Daichi Inoue, Toshio Kitamura

Cell Reports　Vol. 39　No. 6　p. 110805-110805　2022/05/10　Research paper (scientific journal)

Mutant ASXL1 induces age-related expansion of phenotypic hematopoietic stem cells through activation of Akt/mTOR pathway

Takeshi Fujino, Susumu Goyama, Yuki Sugiura, Daichi Inoue, Shuhei Asada, Satoshi Yamasaki, Akiko Matsumoto, Kiyoshi Yamaguchi, Yumiko Isobe, Akiho Tsuchiya, Shiori Shikata, Naru Sato, Hironobu Morinaga, Tomofusa Fukuyama, Yosuke Tanaka, Tsuyoshi Fukushima, Reina Takeda, Keita Yamamoto, Hiroaki Honda, Emi K. Nishimura, Yoichi Furukawa, Tatsuhiro Shibata, Omar Abdel-Wahab, Makoto Suematsu, Toshio Kitamura

Nature Communications　Vol. 12　No. 1　p. 1826-1826　2021/12　Research paper (scientific journal)

ASXL1 mutations are associated with distinct epigenomic alterations that lead to sensitivity to venetoclax and azacytidine.

Nora E Rahmani, Nandini Ramachandra, Srabani Sahu, Nadege Gitego, Andrea Lopez, Kith Pradhan, Tushar D Bhagat, Shanisha Gordon-Mitchell, Bianca Rivera Pena, Mohammad Kazemi, Keshav Rao, Orsi Giricz, Shahina Bano Maqbool, Raul Olea, Yongmei Zhao, Jinghang Zhang, Hamid Dolatshad, Vickram Tittrea, Dharamveer Tatwavedi, Shalini Singh, Juseong Lee, Tianyu Sun, Ulrich Steidl, Aditi Shastri, Daichi Inoue, Omar Abdel-Wahab, Andrea Pellagatti, Evripidis Gavathiotis, Jacqueline Boultwood, Amit Verma

Blood cancer journal　Vol. 11　No. 9　p. 157-157　2021/09/21　Research paper (scientific journal)

Targeting low-risk myelodysplastic syndrome with novel therapeutic strategies

Gaurang Trivedi, Daichi Inoue, Lingbo Zhang

Trends in Molecular Medicine　Vol. 27　No. 10　p. 990-999　2021/07　Research paper (scientific journal)

Minor intron retention drives clonal hematopoietic disorders and diverse cancer predisposition

Daichi Inoue, Jacob T. Polaski, Justin Taylor, Pau Castel, Sisi Chen, Susumu Kobayashi, Simon J. Hogg, Yasutaka Hayashi, Jose Mario Bello Pineda, Ettaib El Marabti, Caroline Erickson, Katherine Knorr, Miki Fukumoto, Hiromi Yamazaki, Atsushi Tanaka, Chie Fukui, Sydney X. Lu, Benjamin H. Durham, Bo Liu, Eric Wang, Sanjoy Mehta, Daniel Zakheim, Ralph Garippa, Alex Penson, Guo-Liang Chew, Frank McCormick, Robert K. Bradley, Omar Abdel-Wahab

Nature Genetics　Vol. 53　No. 5　p. 707-718　2021/05　Research paper (scientific journal)

HHEX promotes myeloid transformation in cooperation with mutant ASXL1.

Reina Takeda, Shuhei Asada, Sung-Joon Park, Akihiko Yokoyama, Hans Jiro Becker, Akinori Kanai, Valeria Visconte, Courtney E Hershberger, Yasutaka Hayashi, Taishi Yonezawa, Moe Tamura, Tsuyoshi Fukushima, Yosuke Tanaka, Tomofusa Fukuyama, Akiko Matsumoto, Satoshi Yamasaki, Kenta Nakai, Satoshi Yamazaki, Toshiya Inaba, Tatsuhiro Shibata, Daichi Inoue, Hiroaki Honda, Susumu Goyama, Jaroslaw P Maciejewski, Toshio Kitamura

Blood　Vol. 136　No. 14　p. 1670-1684　2020/06/03　Research paper (scientific journal)

[Understanding and therapeutic targeting of aberrant mRNA splicing mechanisms in oncogenesis].

Atsushi Tanaka, Susumu Kobayashi, Muran Xiao, Daichi Inoue

[Rinsho ketsueki] The Japanese journal of clinical hematology　Vol. 61　No. 6　p. 643-650　2020　Research paper (scientific journal)

Spliceosomal Disruption of the Non-Canonical SWI/SNF Chromatin Remodeling Complex in SF3B1 Mutant Leukemias

Daichi Inoue, Chew Guo-Liang, Bo Liu, Stanley C Lee, Brittany C Michel, Joey Pangallo, Andrew R D'Avino, Khrystyna North, Lillian E Bitner, Muran Xiao, Susumu Kobayashi, Akihide Yoshimi, Hana Cho, Sydney X Lu, Justin Taylor, Cigall Kadoch, Robert K. Bradley, Omar Abdel-Wahab

Blood　Vol. 134　No. Supplement_1　p. 637-637　2019/11/13　Research paper (scientific journal)

Aberrant RNA Splicing Contributes to the Pathogenesis of EVI-Rearranged Myeloid Leukemias

Daichi Inoue, Stanley C Lee, Akihide Yoshimi, Justin Taylor, Lillian E Bitner, Atsushi Tanaka, Yasutaka Hayashi, Hana Cho, Chie Fukui, Ruth Saganty, Alexander V Penson, Omar Abdel-Wahab

Blood　Vol. 134　No. Supplement_1　p. 917-917　2019/11/13　Research paper (scientific journal)

Mutant ASXL1 Promotes Expansion of the Phenotypic Hematopoietic Stem Cell Compartment

Takeshi Fujino, Susumu Goyama, Yuki Sugiura, Daichi Inoue, Satoshi Yamasaki, Akiko Matsumoto, Naru Sato, Hironobu Morinaga, Shiori Shikata, Tomofusa Fukuyama, Yosuke Tanaka, Shuhei Asada, Tsuyoshi Fukushima, Hiroaki Honda, Emi K Nishimura, Tatsuhiro Shibata, Makoto Suematsu, Toshio Kitamura

Blood　Vol. 134　No. Supplement_1　p. 821-821　2019/11/13　Research paper (scientific journal)

Altered Nuclear Export Signal Recognition as a Driver of Oncogenesis.

Justin Taylor, Maria Sendino, Alexander N Gorelick, Alessandro Pastore, Matthew T Chang, Alexander V Penson, Elena I Gavrila, Connor Stewart, Ella M Melnik, Florisela Herrejon Chavez, Lillian Bitner, Akihide Yoshimi, Stanley Chun-Wei Lee, Daichi Inoue, Bo Liu, Xiao J Zhang, Anthony R Mato, Ahmet Dogan, Michael G Kharas, Yuhong Chen, Demin Wang, Rajesh K Soni, Ronald C Hendrickson, Gorka Prieto, Jose A Rodriguez, Barry S Taylor, Omar Abdel-Wahab

Cancer Discovery　Vol. 9　No. 10　p. 1452-1467　2019/10　Research paper (scientific journal)

Coordinated alterations in RNA splicing and epigenetic regulation drive leukaemogenesis.

Akihide Yoshimi, Kuan-Ting Lin, Daniel H Wiseman, Mohammad Alinoor Rahman, Alessandro Pastore, Bo Wang, Stanley Chun-Wei Lee, Jean-Baptiste Micol, Xiao Jing Zhang, Stephane de Botton, Virginie Penard-Lacronique, Eytan M Stein, Hana Cho, Rachel E Miles, Daichi Inoue, Todd R Albrecht, Tim C P Somervaille, Kiran Batta, Fabio Amaral, Fabrizio Simeoni, Deepti P Wilks, Catherine Cargo, Andrew M Intlekofer, Ross L Levine, Heidi Dvinge, Robert K Bradley, Eric J Wagner, Adrian R Krainer, Omar Abdel-Wahab

Nature　Vol. 574　No. 7777　p. 273-277　2019/10　Research paper (scientific journal)

Spliceosomal disruption of the non-canonical BAF complex in cancer.

Daichi Inoue, Guo-Liang Chew, Bo Liu, Brittany C Michel, Joseph Pangallo, Andrew R D'Avino, Tyler Hitchman, Khrystyna North, Stanley Chun-Wei Lee, Lillian Bitner, Ariele Block, Amanda R Moore, Akihide Yoshimi, Luisa Escobar-Hoyos, Hana Cho, Alex Penson, Sydney X Lu, Justin Taylor, Yu Chen, Cigall Kadoch, Omar Abdel-Wahab, Robert K Bradley

Nature　Vol. 574　No. 7778　p. 432-436　2019/10　Research paper (scientific journal)

Muscarinic acetylcholine receptor regulates self-renewal of early erythroid progenitors.

Gaurang Trivedi, Daichi Inoue, Cynthia Chen, Lillian Bitner, Young Rock Chung, Justin Taylor, Mithat Gönen, Jürgen Wess, Omar Abdel-Wahab, Lingbo Zhang

Science translational medicine　Vol. 11　No. 511　2019/09/25　Research paper (scientific journal)

Myelodysplastic/myeloproliferative neoplasm with ring sideroblasts and thrombocytosis (MDS/MPN with RS-T) complicated by hyperleukocytosis and gene analysis in relation to leukocytosis.

Yumi Aoyama, Kazuko Sakai, Taiichi Kodaka, Hiroko Tsunemine, Kazuto Nishio, Tomoo Itoh, Daichi Inoue, Takayuki Takahashi

Journal of clinical and experimental hematopathology : JCEH　Vol. 59　No. 1　p. 29-33　2019/03/27　Research paper (scientific journal)

Targeting an RNA-Binding Protein Network in Acute Myeloid Leukemia.

Eric Wang, Sydney X Lu, Alessandro Pastore, Xufeng Chen, Jochen Imig, Stanley Chun-Wei Lee, Kathryn Hockemeyer, Yohana E Ghebrechristos, Akihide Yoshimi, Daichi Inoue, Michelle Ki, Hana Cho, Lillian Bitner, Andreas Kloetgen, Kuan-Ting Lin, Taisuke Uehara, Takashi Owa, Raoul Tibes, Adrian R Krainer, Omar Abdel-Wahab, Iannis Aifantis

Cancer Cell　Vol. 35　No. 3　p. 369-384　2019/03/18　Research paper (scientific journal)

ASXL1 and SETBP1 mutations promote leukaemogenesis by repressing TGFβ pathway genes through histone deacetylation.

Makoto Saika, Daichi Inoue, Reina Nagase, Naru Sato, Akiho Tsuchiya, Tomohiro Yabushita, Toshio Kitamura, Susumu Goyama

Scientific reports　Vol. 8　No. 1　p. 15873-15873　2018/10/26　Research paper (scientific journal)

ASXL1 as a critical regulator of epigenetic marks and therapeutic potential of mutated cells.

Daichi Inoue, Takeshi Fujino, Toshio Kitamura

Oncotarget　Vol. 9　No. 81　p. 35203-35204　2018/10/16

ASXL1変異は造血幹・前駆細胞におけるミトコンドリアの機能亢進とDNA損傷を惹起する(Mutant ASXL1 induces mitochondrial dysregulation and ROS-mediated DNA damage in haematopoietic cells)

藤野 赳至, 合山 進, 杉浦 悠毅, 井上 大地, 山崎 智, 松本 明子, 佐藤 成, 森永 浩伸, 四方 紫織, 永瀬 玲奈, 福山 朋房, 田中 洋介, 浅田 修平, 福島 剛, 本田 浩章, 西村 栄美, 柴田 龍弘, Abdel-Wahab Omar, 末松 誠, 北村 俊雄

臨床血液　Vol. 59　No. 9　p. 1518-1518　2018/09

Oncogenic TRK fusions are amenable to inhibition in hematologic malignancies.

Justin Taylor, Dean Pavlick, Akihide Yoshimi, Christina Marcelus, Stephen S Chung, Jaclyn F Hechtman, Ryma Benayed, Emiliano Cocco, Benjamin H Durham, Lillian Bitner, Daichi Inoue, Young Rock Chung, Kerry Mullaney, Justin M Watts, Eli L Diamond, Lee A Albacker, Tariq I Mughal, Kevin Ebata, Brian B Tuch, Nora Ku, Maurizio Scaltriti, Mikhail Roshal, Maria Arcila, Siraj Ali, David M Hyman, Jae H Park, Omar Abdel-Wahab

The Journal of clinical investigation　Vol. 128　No. 9　p. 3819-3825　2018/08/31　Research paper (scientific journal)

Synthetic Lethal and Convergent Biological Effects of Cancer-Associated Spliceosomal Gene Mutations.

Stanley Chun-Wei Lee, Khrystyna North, Eunhee Kim, Eunjung Jang, Esther Obeng, Sydney X Lu, Bo Liu, Daichi Inoue, Akihide Yoshimi, Michelle Ki, Mirae Yeo, Xiao Jing Zhang, Min Kyung Kim, Hana Cho, Young Rock Chung, Justin Taylor, Benjamin H Durham, Young Joon Kim, Alessandro Pastore, Sebastien Monette, James Palacino, Michael Seiler, Silvia Buonamici, Peter G Smith, Benjamin L Ebert, Robert K Bradley, Omar Abdel-Wahab

Cancer Cell　Vol. 34　No. 2　p. 225-241　2018/08/13　Research paper (scientific journal)

Mutant ASXL1 cooperates with BAP1 to promote myeloid leukaemogenesis.

Shuhei Asada, Susumu Goyama, Daichi Inoue, Shiori Shikata, Reina Takeda, Tsuyoshi Fukushima, Taishi Yonezawa, Takeshi Fujino, Yasutaka Hayashi, Kimihito Cojin Kawabata, Tomofusa Fukuyama, Yosuke Tanaka, Akihiko Yokoyama, Satoshi Yamazaki, Hiroko Kozuka-Hata, Masaaki Oyama, Shinya Kojima, Masahito Kawazu, Hiroyuki Mano, Toshio Kitamura

Nature Communications　Vol. 9　No. 1　p. 2733-2733　2018/07/16　Research paper (scientific journal)

Expression of mutant Asxl1 perturbs hematopoiesis and promotes susceptibility to leukemic transformation.

Reina Nagase, Daichi Inoue, Alessandro Pastore, Takeshi Fujino, Hsin-An Hou, Norimasa Yamasaki, Susumu Goyama, Makoto Saika, Akinori Kanai, Yasuyuki Sera, Sayuri Horikawa, Yasunori Ota, Shuhei Asada, Yasutaka Hayashi, Kimihito Cojin Kawabata, Reina Takeda, Hwei-Fang Tien, Hiroaki Honda, Omar Abdel-Wahab, Toshio Kitamura

The Journal of experimental medicine　Vol. 215　No. 6　p. 1729-1747　2018/06/04　Research paper (scientific journal)

A novel ASXL1-OGT axis plays roles in H3K4 methylation and tumor suppression in myeloid malignancies.

Daichi Inoue, Takeshi Fujino, Paul Sheridan, Yao-Zhong Zhang, Reina Nagase, Sayuri Horikawa, Zaomin Li, Hirotaka Matsui, Akinori Kanai, Makoto Saika, Rui Yamaguchi, Hiroko Kozuka-Hata, Kimihito Cojin Kawabata, Akihiko Yokoyama, Susumu Goyama, Toshiya Inaba, Seiya Imoto, Satoru Miyano, Mingjiang Xu, Feng-Chun Yang, Masaaki Oyama, Toshio Kitamura

Leukemia　Vol. 32　No. 6　p. 1327-1337　2018/06　Research paper (scientific journal)

High expression of ABCG2 induced by EZH2 disruption plays pivotal roles in MDS pathogenesis.

Kawabata KC, Hayashi Y, Inoue D, Meguro H, Sakurai H, Fukuyama T, Tanaka Y, Asada S, Fukushima T, Nagase R, Takeda R, Harada Y, Kitaura J, Goyama S, Harada H, Aburatani H, Kitamura T

Leukemia　Vol. 32　No. 2　p. 419-428　2018　Research paper (scientific journal)

ASXL2 is essential for haematopoiesis and acts as a haploinsufficient tumour suppressor in leukemia.

Jean-Baptiste Micol, Alessandro Pastore, Daichi Inoue, Nicolas Duployez, Eunhee Kim, Stanley Chun-Wei Lee, Benjamin H Durham, Young Rock Chung, Hana Cho, Xiao Jing Zhang, Akihide Yoshimi, Andrei Krivtsov, Richard Koche, Eric Solary, Amit Sinha, Claude Preudhomme, Omar Abdel-Wahab

Nature communications　Vol. 8　p. 15429-15429　2017/05/18　Research paper (scientific journal)

Modeling SF3B1 Mutations in Cancer: Advances, Challenges, and Opportunities.

Daichi Inoue, Omar Abdel-Wahab

Cancer cell　Vol. 30　No. 3　p. 371-373　2016/09/12

Biological implications of somatic DDX41 p.R525H mutation in acute myeloid leukemia.

Moe Kadono, Akinori Kanai, Akiko Nagamachi, Satoru Shinriki, Jin Kawata, Koji Iwato, Taiichi Kyo, Kumi Oshima, Akihiko Yokoyama, Takeshi Kawamura, Reina Nagase, Daichi Inoue, Toshio Kitamura, Toshiya Inaba, Tatsuo Ichinohe, Hirotaka Matsui

Experimental hematology　Vol. 44　No. 8　p. 745-754　2016/08　Research paper (scientific journal)

Spliceosomal gene mutations in myelodysplasia: molecular links to clonal abnormalities of hematopoiesis.

Daichi Inoue, Robert K Bradley, Omar Abdel-Wahab

Genes & development　Vol. 30　No. 9　p. 989-1001　2016/05/01

Truncation mutants of ASXL1 observed in myeloid malignancies are expressed at detectable protein levels.

Daichi Inoue, Masaki Matsumoto, Reina Nagase, Makoto Saika, Takeshi Fujino, Keiichi I Nakayama, Toshio Kitamura

Experimental hematology　Vol. 44　No. 3　p. 172-6　2016/03

Novel working hypothesis for pathogenesis of hematological malignancies: combination of mutations-induced cellular phenotypes determines the disease (cMIP-DD).

Toshio Kitamura, Naoko Watanabe-Okochi, Yutaka Enomoto, Fumio Nakahara, Toshihiko Oki, Yukiko Komeno, Naoko Kato, Noriko Doki, Tomoyuki Uchida, Yuki Kagiyama, Katsuhiro Togami, Kimihito C Kawabata, Koutarou Nishimura, Yasutaka Hayashi, Reina Nagase, Makoto Saika, Tsuyoshi Fukushima, Shuhei Asada, Takeshi Fujino, Yuto Izawa, Sayuri Horikawa, Tomofusa Fukuyama, Yosuke Tanaka, Ryoichi Ono, Susumu Goyama, Tetsuya Nosaka, Jiro Kitaura, Daichi Inoue

Journal of biochemistry　Vol. 159　No. 1　p. 17-25　2016/01　Research paper (scientific journal)

THE STABILITY OF EPIGENETIC FACTOR ASXL1 IS REGULATED THROUGH UBIQUITINATION AND USP7-MEDIATED DEUBIQUITINATION

D. Inoue, R. Nagase, M. Saika, K. Nishimura, M. Oyama, T. Kitamura

LEUKEMIA RESEARCH　Vol. 39　p. S71-S71　2015/04

SETBP1 mutations drive leukemic transformation in ASXL1-mutated MDS

D. Inoue, J. Kitaura, H. Matsui, H-A Hou, W-C Chou, A. Nagamachi, K. C. Kawabata, K. Togami, R. Nagase, S. Horikawa, M. Saika, J-B Micol, Y. Hayashi, Y. Harada, H. Harada, T. Inaba, H-F Tien, O. Abdel-Wahab, T. Kitamura

LEUKEMIA　Vol. 29　No. 4　p. 847-857　2015/04　Research paper (scientific journal)

A C-terminal mutant of CCAAT-enhancer-binding protein α (C/EBPα-Cm) downregulates Csf1r, a potent accelerator in the progression of acute myeloid leukemia with C/EBPα-Cm.

Katsuhiro Togami, Jiro Kitaura, Tomoyuki Uchida, Daichi Inoue, Koutarou Nishimura, Kimihito C Kawabata, Reina Nagase, Sayuri Horikawa, Kumi Izawa, Tomofusa Fukuyama, Fumio Nakahara, Toshihiko Oki, Yuka Harada, Hironori Harada, Hiroyuki Aburatani, Toshio Kitamura

Experimental hematology　Vol. 43　No. 4　p. 300-8　2015/04　Research paper (scientific journal)

[Molecular basis of hematological malignancies].

Toshio Kitamura, Daichi Inoue, Fumio Nakahara, Naoko Okochi, Naoko Kato, Katsuhiro Togami, Tomoyuki Uchida, Yuki Kagiyama, Kimihito Cojin Kawabata, Reina Nagase, Sayuri Horikawa, Kouki Hayashi, Makoto Saika, Kumi Izawa, Toshihiko Oki, Shigeru Chiba, Yuka Harada, Hironori Harada, Jiro Kitaura

[Rinsho ketsueki] The Japanese journal of clinical hematology　Vol. 55　No. 10　p. 1715-23　2014/10　Research paper (scientific journal)

Hes1 promotes blast crisis in chronic myelogenous leukemia through MMP-9 upregulation in leukemic cells.

Fumio Nakahara, Jiro Kitaura, Tomoyuki Uchida, Chiemi Nishida, Katsuhiro Togami, Daichi Inoue, Toshihiro Matsukawa, Yuki Kagiyama, Yutaka Enomoto, Kimihito C Kawabata, Lai Chen-Yi, Yukiko Komeno, Kumi Izawa, Toshihiko Oki, Genta Nagae, Yuka Harada, Hironori Harada, Makoto Otsu, Hiroyuki Aburatani, Beate Heissig, Koichi Hattori, Toshio Kitamura

Blood　Vol. 123　No. 25　p. 3932-42　2014/06/19　Research paper (scientific journal)

Hes1 upregulation contributes to the development of FIP1L1-PDGRA-positive leukemia in blast crisis.

Tomoyuki Uchida, Jiro Kitaura, Fumio Nakahara, Katsuhiro Togami, Daichi Inoue, Akie Maehara, Koutarou Nishimura, Kimihito C Kawabata, Noriko Doki, Kazuhiko Kakihana, Kosuke Yoshioka, Kumi Izawa, Toshihiko Oki, Akiko Sada, Yuka Harada, Kazuteru Ohashi, Yoshio Katayama, Toshimitsu Matsui, Hironori Harada, Toshio Kitamura

Experimental hematology　Vol. 42　No. 5　p. 369-379　2014/05　Research paper (scientific journal)

IP-10/CXCL10 and MIG/CXCL9 as novel markers for the diagnosis of lymphoma-associated hemophagocytic syndrome.

Hayato Maruoka, Daichi Inoue, Yoko Takiuchi, Seiji Nagano, Hiroshi Arima, Sumie Tabata, Akiko Matsushita, Takayuki Ishikawa, Tatsuo Oita, Takayuki Takahashi

Annals of hematology　Vol. 93　No. 3　p. 393-401　2014/03　Research paper (scientific journal)

The molecular basis of myeloid malignancies.

Toshio Kitamura, Daichi Inoue, Naoko Okochi-Watanabe, Naoko Kato, Yukiko Komeno, Yang Lu, Yutaka Enomoto, Noriko Doki, Tomoyuki Uchida, Yuki Kagiyama, Katsuhiro Togami, Kimihito C Kawabata, Reina Nagase, Sayuri Horikawa, Yasutaka Hayashi, Makoto Saika, Tomofusa Fukuyama, Kumi Izawa, Toshihiko Oki, Fumio Nakahara, Jiro Kitaura

Proceedings of the Japan Academy. Series B, Physical and biological sciences　Vol. 90　No. 10　p. 389-404　2014　Research paper (scientific journal)

Simultaneous thrombosis of the mesenteric artery and vein as a novel clinical manifestation of intravascular large B-cell lymphoma.

Hiroshi Arima, Daichi Inoue, Sumie Tabata, Akiko Matsushita, Yukihiro Imai, Takayuki Ishikawa, Takayuki Takahashi

Acta haematologica　Vol. 132　No. 1　p. 108-11　2014　Research paper (scientific journal)

Myelodysplastic syndromes are induced by histone methylation–altering ASXL1 mutations.

Daichi Inoue, Jiro Kitaura, Katsuhiro Togami, Koutarou Nishimura, Yutaka Enomoto, Tomoyuki Uchida, Yuki Kagiyama, Kimihito Cojin Kawabata, Fumio Nakahara, Kumi Izawa, Toshihiko Oki, Akie Maehara, Masamichi Isobe, Akiho Tsuchiya, Yuka Harada, Hironori Harada, Takahiro Ochiya, Hiroyuki Aburatani, Hiroshi Kimura, Felicitas Thol, Michael Heuser, Ross L Levine, Omar Abdel-Wahab, Toshio Kitamura

The Journal of clinical investigation　Vol. 123　No. 11　p. 4627-40　2013/11　Research paper (scientific journal)

RUNX1/AML1 mutant collaborates with BMI1 overexpression in the development of human and murine myelodysplastic syndromes.

Yuka Harada, Daichi Inoue, Ye Ding, Jun Imagawa, Noriko Doki, Hirotaka Matsui, Takashi Yahata, Hiromichi Matsushita, Kiyoshi Ando, Goro Sashida, Atsushi Iwama, Toshio Kitamura, Hironori Harada

Blood　Vol. 121　No. 17　p. 3434-46　2013/04/25　Research paper (scientific journal)

Upregulation of CD200R1 in lineage-negative leukemic cells is characteristic of AML1-ETO-positive leukemia in mice.

Yuki Kagiyama, Jiro Kitaura, Katsuhiro Togami, Tomoyuki Uchida, Daichi Inoue, Toshihiro Matsukawa, Kumi Izawa, Kimihito C Kawabata, Yukiko Komeno, Toshihiko Oki, Fumio Nakahara, Katsuaki Sato, Hiroyuki Aburatani, Toshio Kitamura

International journal of hematology　Vol. 96　No. 5　p. 638-48　2012/11　Research paper (scientific journal)

HDACI-induced thrombocytopenia is caused by its unexpected target.

Toshio Kitamura, Daichi Inoue

Experimental hematology　Vol. 40　No. 9　p. 695-7　2012/09

[Molecular mechanisms underlying leukemic transformation of myelodysplastic syndromes (MDS) and chronic myelogenous leukemia (CML)].

Toshio Kitamura, Naoko Watanabe-Okochi, Daichi Inoue, Katsuhiro Togami, Tomoyuki Uchida, Yuuki Kagiyama, Kimihito Kawabata, Shigeru Chiba, Yuka Harada, Hironori Harada, Jiro Kitaura, Fumio Nakahara

[Rinsho ketsueki] The Japanese journal of clinical hematology　Vol. 53　No. 8　p. 734-9　2012/08　Research paper (scientific journal)

A novel clinical entity, IgG4-related disease (IgG4RD): general concept and details

Hisanori Umehara, Kazuichi Okazaki, Yasufumi Masaki, Mitsuhiro Kawano, Motohisa Yamamoto, Takako Saeki, Shoko Matsui, Takayuki Sumida, Tsuneyo Mimori, Yoshiya Tanaka, Kazuo Tsubota, Tadashi Yoshino, Shigeyuki Kawa, Ritsuro Suzuki, Tsutomu Takegami, Naohisa Tomosugi, Nozomu Kurose, Yasuhito Ishigaki, Atsushi Azumi, Masaru Kojima, Shigeo Nakamura, Dai Inoue

MODERN RHEUMATOLOGY　Vol. 22　No. 1　p. 1-14　2012/02

Fyn is not essential for Bcr-Abl-induced leukemogenesis in mouse bone marrow transplantation models.

Noriko Doki, Jiro Kitaura, Tomoyuki Uchida, Daichi Inoue, Yuki Kagiyama, Katsuhiro Togami, Masamichi Isobe, Shinichi Ito, Akie Maehara, Kumi Izawa, Naoko Kato, Toshihiko Oki, Yuka Harada, Fumio Nakahara, Hironori Harada, Toshio Kitamura

International journal of hematology　Vol. 95　No. 2　p. 167-75　2012/02　Research paper (scientific journal)

Bacillus cereus Sepsis in the Treatment of Acute Myeloid Leukemia.

Inoue D, Takahashi T

Myeloid Leukemia　2012

Successful treatment of γ-heavy-chain disease with rituximab and fludarabine.

Daichi Inoue, Akiko Matsushita, Mineyo Kiuchi, Yoko Takiuchi, Seiji Nagano, Hiroshi Arima, Minako Mori, Sumie Tabata, Akiko Yamashiro, Hayato Maruoka, Tatsuo Oita, Yukihiro Imai, Takayuki Takahashi

Acta haematologica　Vol. 128　No. 3　p. 139-43　2012　Research paper (scientific journal)

Leukemic manifestation of blastic plasmacytoid dendritic cell neoplasm lacking skin lesion : a borderline case between acute monocytic leukemia.

Yoko Takiuchi, Hayato Maruoka, Kazunari Aoki, Aiko Kato, Yuichiro Ono, Seiji Nagano, Hiroshi Arima, Daichi Inoue, Minako Mori, Sumie Tabata, Soshi Yanagita, Akiko Matsushita, Mari Nishio, Yukihiro Imai, Yukihiro Imai, Kiminari Ito, Haruyuki Fujita, Norimitsu Kadowaki, Takayuki Ishikawa, Takayuki Takahashi

Journal of clinical and experimental hematopathology : JCEH　Vol. 52　No. 2　p. 107-11　2012　Research paper (scientific journal)

[Exacerbation of autoimmune neutropenia to agranulocytosis in association with severe autoimmune thrombocytopenia and hemolytic anemia in a patient with Sjögren's syndrome].

Sonoko Shimoji, Yohko Takiuchi, Hayato Maruoka, Daichi Inoue, Takaharu Kimura, Minako Mori, Yuya Nagai, Katuhiro Togami, Sumie Tabata, Masayuki Kurata, Akiko Matsushita, Kenichi Nagai, Takayuki Takahashi

[Rinsho ketsueki] The Japanese journal of clinical hematology　Vol. 52　No. 7　p. 535-9　2011/07

Blastic plasmacytoid dendritic cell neoplasm expressing the CD13 myeloid antigen.

Daichi Inoue, Kyoko Maruyama, Kazunari Aoki, Seiji Nagano, Hayato Maruoka, Yukihiro Imai, Kiminari Ito, Takayuki Ishikawa, Takayuki Takahashi

Acta Haematologica　Vol. 126　No. 2　p. 122-8　2011　Research paper (scientific journal)

Excellent therapeutic effect of tocilizumab on intestinal amyloid a deposition secondary to active rheumatoid arthritis.

Daichi Inoue, Hiroshi Arima, Chiharu Kawanami, Yoko Takiuchi, Seiji Nagano, Takaharu Kimura, Sonoko Shimoji, Minako Mori, Sumie Tabata, Soshi Yanagita, Akiko Matsushita, Kenichi Nagai, Yukihiro Imai, Takayuki Takahashi

Clinical Rheumatology　Vol. 29　No. 10　p. 1195-7　2010/10　Research paper (scientific journal)

MOLECULAR BASIS FOR AML, MDS AND MPN

T. Kitamura, F. Nakahara, N. Kato, N. Watanabe-Okochi, Y. Komeno, N. Doki, K. Togami, T. Uchida, Y. Kagiyama, D. Inoue, Y. Enomoto, T. Oki, H. Harada, S. Chiba, J. Kitaura

EXPERIMENTAL HEMATOLOGY　Vol. 38　No. 9　p. S107-S108　2010/09　Research paper (international conference proceedings)

Clinical analysis and optimization of postremission therapy for acute myeloid leukemia patients with minimal residual disease as determined by flow cytometry.

Daichi Inoue, Hayato Maruoka, Takayuki Takahashi

Mediterranean journal of hematology and infectious diseases　Vol. 2　No. 2　2010/08/05

Histiocytic sarcoma and underlying chronic myelomonocytic leukemia: a proposal for the developmental classification of histiocytic sarcoma.

Minako Mori, Akiko Matsushita, Yohko Takiuchi, Hiroshi Arima, Seiji Nagano, Sonoko Shimoji, Takaharu Kimura, Daichi Inoue, Sumie Tabata, Sohshi Yanagita, Kenichi Nagai, Yukihiro Imai, Takayuki Takahashi

International journal of hematology　Vol. 92　No. 1　p. 168-73　2010/07　Research paper (scientific journal)

[Graft-versus-leukemia effect by lymphocytes from the first donor after second cord blood transplantation in a patient with T-lymphoblastic lymphoma].

Kenichi Nagai, Hisako Hashimoto, Kiminari Itoh, Akiko Matsushita, Sonoko Shimoji, Takaharu Kimura, Daichi Inoue, Minako Mori, Yuya Nagai, Sumie Tabata, Muneyuki Yanagida, Takayuki Takahashi

[Rinsho ketsueki] The Japanese journal of clinical hematology　Vol. 51　No. 6　p. 413-21　2010/06

治療抵抗性血管免疫芽球性T細胞性リンパ腫に対するCyclosporin Aの有用性

森 美奈子, 井上 大地, 有馬 浩史, 瀧内 曜子, 永野 誠治, 木村 隆治, 下地 園子, 永井 雄也, 田端 淑恵, 柳田 宗之, 松下 章子, 永井 謙一, 今井 幸弘, 高橋 隆幸

臨床血液　Vol. 51　No. 5　p. 332-338　2010/05

[Therapeutic efficacy of cyclosporin A for refractory angioimmunoblastic T cell lymphoma].

Minako Mori, Daichi Inoue, Hiroshi Arima, Yohko Takiuchi, Seiji Nagano, Takaharu Kimura, Sonoko Shimoji, Yuya Nagai, Sumie Tabata, Sohshi Yanagita, Akiko Matsushita, Kenichi Nagai, Yukihiro Imai, Takayuki Takahashi

[Rinsho ketsueki] The Japanese journal of clinical hematology　Vol. 51　No. 5　p. 332-8　2010/05　Research paper (scientific journal)

Fulminant sepsis caused by Bacillus cereus in patients with hematologic malignancies: analysis of its prognosis and risk factors.

Daichi Inoue, Yuya Nagai, Minako Mori, Seiji Nagano, Yoko Takiuchi, Hiroshi Arima, Takaharu Kimura, Sonoko Shimoji, Katsuhiro Togami, Sumie Tabata, Soshi Yanagita, Akiko Matsushita, Kenichi Nagai, Yukihiro Imai, Hiroshi Takegawa, Takayuki Takahashi

Leukemia & Lymphoma　Vol. 51　No. 5　p. 860-9　2010/05　Research paper (scientific journal)

Successful living donor liver transplantation for severe hepatic GVHD histologically resembling autoimmune hepatitis after bone marrow transplantation from the same sibling donor.

Minako Mori, Sumie Tabata, Hisako Hashimoto, Daichi Inoue, Takaharu Kimura, Sonoko Shimoji, Yuya Nagai, Katsuhiro Togami, Kiminari Itoh, Akiko Matsushita, Kenichi Nagai, Eiji Ikeda, Naoya Kimoto, Kenji Uryuhara, Satoru Kaihara, Yukihiro Imai, Masafumi Itoh, Takayuki Takahashi

Transplant international : official journal of the European Society for Organ Transplantation　Vol. 23　No. 5　2010/05/01

Successful treatment of extranodal natural killer/T-cell lymphoma, nasal type, complicated by severe hemophagocytic syndrome, with dexamethasone, methotrexate, ifosfamide, L-asparaginase, and etoposide chemotherapy followed by autologous stem cell transplant.

Daichi Inoue, Yuya Nagai, Yoko Takiuchi, Seiji Nagano, Hiroshi Arima, Takaharu Kimura, Sonoko Shimoji, Minako Mori, Katsuhiro Togami, Sumie Tabata, Soshi Yanagita, Akiko Matsushita, Kenichi Nagai, Hayato Maruoka, Yukihiro Imai, Ritsuro Suzuki, Takayuki Takahashi

Leukemia & lymphoma　Vol. 51　No. 4　p. 720-3　2010/04

Hepatosplenic alphabeta T cell lymphoma.

Yuya Nagai, Kazuhiro Ikegame, Minako Mori, Daichi Inoue, Takaharu Kimura, Sonoko Shimoji, Katsuhiro Togami, Sumie Tabata, Masayuki Kurata, Yukihiro Imai, Akiko Matsushita, Kenichi Nagai, Hiroyasu Ogawa, Takayuki Takahashi

International journal of clinical oncology　Vol. 15　No. 2　p. 215-9　2010/04

[Early diagnosis and successful treatment of catastrophic antiphospholipid syndrome complicated by multiple organ failure].

Daichi Inoue, Katsuhiro Togami, Norihiro Shimoike, Ryo Tamura, Yukihiro Imai, Takaharu Kimura, Sonoko Shimoji, Minako Mori, Yuya Nagai, Sumie Tabata, Akiko Matsushita, Kenichi Nagai, Takayuki Takahashi

Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology　Vol. 33　No. 1　p. 24-30　2010

Successful treatment of POEMS syndrome complicated by severe congestive heart failure with thalidomide.

Daichi Inoue, Aiko Kato, Sumie Tabata, Takeshi Kitai, Yoko Takiuchi, Takaharu Kimura, Sonoko Shimoji, Minako Mori, Yuya Nagai, Katsuhiro Togami, Akiko Matsushita, Kenichi Nagai, Hayato Maruoka, Yukihiro Imai, Minako Beppu, Michi Kawamoto, Takayuki Takahashi

Internal medicine (Tokyo, Japan)　Vol. 49　No. 5　p. 461-6　2010

Successful allogeneic bone marrow transplantation for diamond-blackfan anemia complicated by severe cardiac dysfunction due to transfusion-induced hemochromatosis.

Sumie Tabata, Minako Mori, Yuya Nagai, Hisako Hashimoto, Hiroshi Arima, Seiji Nagano, Yoko Takiuchi, Daichi Inoue, Takaharu Kimura, Sonoko Shimoji, Soshi Yanagita, Kiminari Ito, Akiko Matsushita, Kenichi Nagai, Takayuki Takahashi

Internal medicine (Tokyo, Japan)　Vol. 49　No. 5　p. 453-6　2010　Research paper (scientific journal)

[Successful treatment of chronic disseminated intravascular coagulation syndrome with continuous subcutaneous infusion of heparin using a mobile infusion pump: report of 2 cases].

Katsuhiro Togami, Yuya Nagai, Hiroshi Arima, Sonoko Shimoji, Takahiro Kimura, Daichi Inoue, Minako Mori, Haruyuki Fujita, Sumie Tabata, Masayuki Kurata, Soshi Yanagida, Akiko Matsushita, Kenichi Nagai, Shuichiroh Kaji, Takayuki Takahashi

[Rinsho ketsueki] The Japanese journal of clinical hematology　Vol. 50　No. 12　p. 1700-5　2009/12　Research paper (scientific journal)

Successful treatment with autologous peripheral blood stem cell transplantation for acquired immunodeficiency syndrome (AIDS)-related malignant lymphoma.

Yuya NAGAI, Minako MORI, Daichi INOUE, Takaharu KIMURA, Sonoko SHIMOJI, Katsuhiro TOGAMI, Sumie TABATA, Akiko MATSUSHITA, Kenichi NAGAI, Yukihiro Imai, Toshiro Takafuta, Takayuki Takahashi

[Rinsho ketsueki] The Japanese journal of clinical hematology　Vol. 50　No. 11　p. 1641-6　2009/11

Successful allogeneic bone marrow transplantation for myelodysplastic syndrome complicated by severe pulmonary alveolar proteinosis.

Sumie Tabata, Sonoko Shimoji, Kimihiko Murase, Yoko Takiuchi, Daichi Inoue, Takaharu Kimura, Yuya Nagai, Minako Mori, Katsuhiro Togami, Masayuki Kurata, Kiminari Ito, Hisako Hashimoto, Akiko Matushita, Kenichi Nagai, Takayuki Takahashi

International journal of hematology　Vol. 90　No. 3　p. 407-412　2009/10　Research paper (scientific journal)

Refractory de novo myeloid sarcoma: a case report and therapeutic strategy based on bone marrow minimal residual disease.

Daichi Inoue, Yuya Nagai, Takaharu Kimura, Sonoko Shimoji, Minako Mori, Katsuhiro Togami, Sumie Tabata, Masayuki Kurata, Akiko Matsushita, Kiminari Ito, Hisako Hashimoto, Hayato Maruoka, Eiko Yamashita, Kenichi Nagai, Yukihiro Imai, Hirohumi Shirane, Takayuki Takahashi

International journal of hematology　Vol. 90　No. 1　p. 120-123　2009/07

[Angioimmunoblastic T-cell lymphoma complicated by recurrent drug-induced agranulocytosis].

Daichi Inoue, Takaharu Kimura, Sonoko Shimoji, Minako Mori, Yuya Nagai, Sumie Tabata, Masayuki Kurata, Akiko Matsushita, Kenichi Nagai, Hayato Maruoka, Eiko Yamashita, Takayuki Takahashi

[Rinsho ketsueki] The Japanese journal of clinical hematology　Vol. 50　No. 2　p. 87-91　2009/02