keyword シトクロムP450，ヘムタンパク質
大阪大学 大学院薬学研究科博士後期課程
2010年4月 ～ 2013年3月
大阪大学 大学院薬学研究科博士前期課程
2008年4月 ～ 2010年3月
大阪大学 薬学部
2004年4月 ～ 2008年3月
日本薬学会
ライフサイエンス / 薬系分析、物理化学 /
Electrochemical Analysis and Inhibition Assay of Immune-Modulating Enzyme, Indoleamine 2,3-Dioxygenase.
Yasuhiro Mie, Chitose Mikami, Yoshiaki Yasutake, Yuki Shigemura, Taku Yamashita, Hirofumi Tsujino
Pharmaceuticals (Basel, Switzerland) Vol. 18 No. 3 2025年2月28日 研究論文（学術雑誌）
Curcumin Is Primarily Distributed in Lung, Spleen and Liver, Metabolized to Glucuronide and Sulfate, and Excreted through Bile and Urine by Using an Amorphous Curcumin Formulation with High Absorbability.
Tomohiro Nakao, Michiko Nakamura, Kazuya Nagano, Mariko Takeda, Haruna Hirai, Hikaru Maekita, Jian-Qing Gao, Hirofumi Tsujino, Makoto Sakata, Masayuki Nishino, Yuya Haga, Kazuma Higashisaka, Yasuo Tsutsumi
Biological & pharmaceutical bulletin Vol. 48 No. 3 p. 314-322 2025年 研究論文（学術雑誌）
Exploring Nile Red Staining as an Analytical Tool for Surface-Oxidized Microplastics
Wakaba Idehara, Yuya Haga, Hirofumi Tsujino, Yudai Ikuno, Sota Manabe, Mii Hokaku, Haruyasu Asahara, Kazuma Higashisaka, Yasuo Tsutsumi
Environmental Research Vol. 269 p. 120934-120934 2025年1月 研究論文（学術雑誌）
出版者・発行元：Elsevier BV
Absorption, Fluorescence, and Two-Photon Excitation Ability of 5-o-Tolyl-11 (or 13)-o-tolylisoindolo[2,1-a]quinolines Prepared by Ring-Closing Metathesis and [2+3] Cycloaddition.
Yuki Wada, Kwangkyun Jang, Hirokazu Ishii, Yuki Watakabe, Motosuke Tsutsumi, Makoto Sako, Tsunayoshi Takehara, Takeyuki Suzuki, Hirofumi Tsujino, Yasuo Tsutsumi, Tomomi Nemoto, Mitsuhiro Arisawa
Chemistry, an Asian journal Vol. 20 No. 2 2024年11月4日 研究論文（学術雑誌）
Treatment of polyethylene microplastics degraded by ultraviolet light irradiation causes lysosome-deregulated cell death
Sota Manabe, Yuya Haga, Hirofumi Tsujino, Yudai Ikuno, Haruyasu Asahara, Kazuma Higashisaka, Yasuo Tsutsumi
Scientific Reports Vol. 14 No. 1 p. 24008-24008 2024年10月14日 研究論文（学術雑誌）
出版者・発行元：Springer Science and Business Media LLC
Polyethylene, whose surface has been modified by UV irradiation, induces cytotoxicity: A comparison with microplastics found in beaches.
Yudai Ikuno, Hirofumi Tsujino, Yuya Haga, Sota Manabe, Wakaba Idehara, Mii Hokaku, Haruyasu Asahara, Kazuma Higashisaka, Yasuo Tsutsumi
Ecotoxicology and environmental safety Vol. 277 p. 116346-116346 2024年6月1日 研究論文（学術雑誌）
Furanyl bis(indolyl)methane as a palladium ion-selective chromogenic agent.
Kazuho Ban, Shiho Nozaki, Takaaki Aijima, Shuki Oyama, Hirofumi Tsujino, Yusuke Kanematsu, Shuji Akai, Yoshinari Sawama
Organic & biomolecular chemistry Vol. 22 No. 14 p. 2734-2738 2024年4月3日 研究論文（学術雑誌）
Coculture with macrophages alters ferroptosis susceptibility of triple-negative cancer cells
Hiroto Konishi, Yuya Haga, Moe Okumura, Hirofumi Tsujino, Kazuma Higashisaka, Yasuo Tsutsumi
Cell Death Discovery Vol. 10 No. 1 p. 108-108 2024年3月1日 研究論文（学術雑誌）
出版者・発行元：Springer Science and Business Media LLC
Polyglycerol fatty acid ester contributes to the improvement and maintenance of water solubility of amorphous curcumin by suppressing the intermolecular interaction and the diffusion rate of curcumin
Kazuya Nagano, Tomohiro Nakao, Mariko Takeda, Haruna Hirai, Hikaru Maekita, Michiko Nakamura, Naoki Imakawa, Ayako Egawa, Toshimichi Fujiwara, Jian-Qing Gao, Keigo Kinoshita, Makoto Sakata, Masayuki Nishino, Takuya Yamashita, Takuya Yoshida, Kazuo Harada, Keisuke Tachibana, Takefumi Doi, Kazumasa Hirata, Hirofumi Tsujino, Kazuma Higashisaka, Yasuo Tsutsumi
Food Chemistry Vol. 437 No. Pt 2 p. 137866-137866 2024年3月 研究論文（学術雑誌）
出版者・発行元：Elsevier BV
劣化したマイクロプラスチックが示す細胞毒性機序の解明
Yuya Haga, Sota Manabe, Hirofumi Tsujino, Haruyasu Asahara, Kazuma Higashisaka, Yasuo Tsutsumi
YAKUGAKU ZASSHI Vol. 144 No. 2 p. 177-181 2024年2月1日 研究論文（学術雑誌）
出版者・発行元：Pharmaceutical Society of Japan
環境中の表面性状を模倣した劣化マイクロプラスチックの作製
Hirofumi Tsujino, Yudai Ikuno, Yuya Haga, Haruyasu Asahara, Kazuma Higashisaka, Yasuo Tsutsumi
YAKUGAKU ZASSHI Vol. 144 No. 2 p. 171-175 2024年2月1日 研究論文（学術雑誌）
出版者・発行元：Pharmaceutical Society of Japan
The Lower Toxicity and Wider Safety Range of Acidic Sophorolipid Compared to Surfactin and Rhamnolipid as Biosurfactants toward the HaCAT, THP-1, and RAW 264.7
Michiaki Araki, Erika Kunimi, Yoshihiko Hirata, Misa Muraoka, Hirofumi Tsujino, Masayoshi Arai, Kazumasa Hirata, Kazuya Nagano
BPB Reports Vol. 7 No. 2 p. 56-60 2024年 研究論文（学術雑誌）
出版者・発行元：Pharmaceutical Society of Japan
[Toward Elucidation of Human Health Effects of Micro/nanoplastics].
Yasuo Tsutsumi, Hirofumi Tsujino
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan Vol. 144 No. 2 p. 163-164 2024年 研究論文（学術雑誌）
Valproic acid elevates HIF-1α-mediated CGB expression and suppresses glucose uptake in BeWo cells.
Go Kitahara, Kazuma Higashisaka, Yurina Nakamoto, Rena Yamamoto, Wakako Okuno, Momoe Serizawa, Yuji Sakahashi, Hirofumi Tsujino, Yuya Haga, Yasuo Tsutsumi
The Journal of toxicological sciences Vol. 49 No. 2 p. 69-77 2024年 研究論文（学術雑誌）
Impact of multiple H/D replacements on the physicochemical properties of flurbiprofen.
Hiromasa Uchiyama, Kazuho Ban, Shiho Nozaki, Yui Ikeda, Takayoshi Ishimoto, Hiroyoshi Fujioka, Mako Kamiya, Ryugo Amari, Hirofumi Tsujino, Masayoshi Arai, Sachi Yamazoe, Keiko Maekawa, Takuma Kato, Mitsunobu Doi, Kazunori Kadota, Yuichi Tozuka, Naohito Tomita, Hironao Sajiki, Shuji Akai, Yoshinari Sawama
RSC medicinal chemistry Vol. 14 No. 12 p. 2583-2592 2023年12月13日 研究論文（学術雑誌）
Impact of Degradation of Polyethylene Particles on Their Cytotoxicity
Yudai Ikuno, Hirofumi Tsujino, Yuya Haga, Haruyasu Asahara, Kazuma Higashisaka, Yasuo Tsutsumi
Microplastics Vol. 2 No. 2 p. 192-201 2023年5月22日 研究論文（学術雑誌）
出版者・発行元：MDPI AG
Fluorouracil exacerbates alpha-crystallin B chain-mediated cell migration in triple-negative breast cancer cell lines.
Lili Yang, Yuya Haga, Akihide Nishimura, Yuki Tsujii, Suzuno Tanahashi, Hirofumi Tsujino, Kazuma Higashisaka, Yasuo Tsutsumi
Scientific reports Vol. 13 No. 1 p. 4010-4010 2023年3月10日 研究論文（学術雑誌）
Silver nanoparticles suppress forskolin-induced syncytialization in BeWo cells
Yuji Sakahashi, Kazuma Higashisaka, Ryo Isaka, Rina Izutani, Jiwon Seo, Atsushi Furuta, Akemi Yamaki-Ushijima, Hirofumi Tsujino, Yuya Haga, Akitoshi Nakashima, Yasuo Tsutsumi
Nanotoxicology Vol. 16 No. 9-10 p. 1-12 2023年1月3日 研究論文（学術雑誌）
出版者・発行元：Informa UK Limited
ベンゾピレン誘導性細胞老化ががん悪性転化へ及ぼす影響
北本 夏子, 芳賀 優弥, 辻井 勇気, 辻野 博文, 東阪 和馬, 堤 康央
日本毒性学会学術年会 Vol. 50.1 2023年
出版者・発行元：日本毒性学会
Absorption, fluorescence, and two-photon excitation ability of 5-phenyl-13-arylisoindolo[2,1-a]quinolines prepared by one-pot reaction of ring-closing metathesis and 1,3-dipolar cycloaddition
Avena Francisco Ramon, Yuki Wada, Hirokazu Ishii, Yuki Watakabe, Motosuke Tsutsumi, Kwangkyun Jang, Kohei Otomo, Lin Qiao, Yuki Fujii, Hirofumi Tsujino, Yasuo Tsutsumi, Tomomi Nemoto, Mitsuhiro Arisawa
Dyes and Pigments p. 111118-111118 2023年1月 研究論文（学術雑誌）
出版者・発行元：Elsevier BV
Silver Nanoparticles Suppress Retinoic Acid-Induced Neuronal Differentiation in Human-Derived Neuroblastoma SH-SY5Y Cells
Shintaro Yamaguchi, Ryo Isaka, Yuji Sakahashi, Hirofumi Tsujino, Yuya Haga, Kazuma Higashisaka, Yasuo Tsutsumi
ACS Applied Nano Materials Vol. 5 No. 12 p. 19025-19034 2022年12月23日 研究論文（学術雑誌）
出版者・発行元：American Chemical Society (ACS)
Osimertinib-tolerant lung cancer cells are susceptible to ferroptosis.
Hiroto Konishi, Yuya Haga, Ying Lin, Hirofumi Tsujino, Kazuma Higashisaka, Yasuo Tsutsumi
Biochemical and biophysical research communications Vol. 641 p. 116-122 2022年12月10日 研究論文（学術雑誌）
Amorphous silica nanoparticles (nSP50) exacerbate hepatic damage through the activation of acquired cell-mediated immunity
Shun-ichi Eto, Kazuma Higashisaka, Aoi Koshida, Kenta Sato, Mao Ogura, Miyuki Sakurai, Hirofumi Tsujino, Kazuya Nagano, Yasuo Tsutsumi
Nano Express Vol. 3 No. 1 p. 015002-015002 2022年3月1日 研究論文（学術雑誌）
出版者・発行元：IOP Publishing
Alpha-crystallin B chains enhance cell migration in basal-like 2 triple-negative breast cancer cells
L. Yang, K. Higashisaka, Y. Haga, H. Tsujino, K. Nagano, Y. Tsutsumi
PHARMAZIE Vol. 77 No. 2 2022年2月 研究論文（学術雑誌）
Identification of biomarkers of chronic kidney disease among kidney-derived proteins.
Kazuma Higashisaka, Sonoko Takeya, Haruhiko Kamada, Masanori Obana, Makiko Maeda, Mai Kabayama, Koichi Yamamoto, Nanan Ishida, Ryo Isaka, Hirofumi Tsujino, Kazuya Nagano, Noriyuki Tomiyama, Hiromi Rakugi, Yasushi Fujio, Kei Kamide, Yasuo Tsutsumi
Clinical proteomics Vol. 19 No. 1 p. 3-3 2022年1月11日 研究論文（学術雑誌）
Amorphas Silica Nanoparticles Decrease Human Chorionic Gonadotropin β Expression During Syncytialization of BeWo Cell
Yuji Sakahashi, Rena Yamamoto, Go Kitahara, Rina Izutani, Hirofumi Tsujino, Yuya Haga, Kazuma Higashisaka, Yasuo Tsutsumi
BPB Reports Vol. 5 No. 6 p. 154-158 2022年 研究論文（学術雑誌）
出版者・発行元：Pharmaceutical Society of Japan
Silica Particles with Human Protein Corona Shows Sensitization Potential in the Human Cell Line Activation Test
Shun-ichi Eto, Aoi Koshida, Hirofumi Tsujino, Kazuya Nagano, Kazuma Higashisaka, Yasuo Tsutsumi
BPB Reports Vol. 5 No. 1 p. 1-4 2022年 研究論文（学術雑誌）
出版者・発行元：Pharmaceutical Society of Japan
Subvisible Particles Derived by Dropping Stress Enhance Anti-PEG Antibody Production and Clearance of PEGylated Proteins in Mice
Takaki Nakajima, Kazuya Nagano, Yuka Fukuda, Yu Ishima, Hiroko Shibata, Ryo Isaka, Tian-qi Zhang, Yuya Haga, Kazuma Higashisaka, Hirofumi Tsujino, Tatsuhiro Ishida, Akiko Ishii-Watabe, Yasuo Tsutsumi
Journal of Pharmaceutical Sciences Vol. 111 No. 5 p. 1363-1369 2022年1月 研究論文（学術雑誌）
出版者・発行元：Elsevier BV
Alpha-crystallin B chains in trastuzumab-resistant breast cancer cells promote endothelial cell tube formation through activating mTOR
Lili Yang, Kazuma Higashisaka, Masafumi Shimoda, Yuya Haga, Naoki Sekine, Hirofumi Tsujino, Kazuya Nagano, Kenzo Shimazu, Yasuo Tsutsumi
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Vol. 588 p. 175-181 2022年1月 研究論文（学術雑誌）
Indoxyl Sulfate Induces an Inflammatory Response in the Proximal Tubule via Macrophages
Isaka R, Ishida N, Kitahara G, Sakahashi Y, Haga Y, Tsujino H, Nagano K, Higashisaka K, Tsutsumi Y
BPB Reports Vol. 4 No. 6 p. 198-201 2021年11月 研究論文（学術雑誌）
出版者・発行元：Pharmaceutical Society of Japan
Carbon-Carbon Bond Formation between N-Heterocyclic Carbene Ligand on Ruthenium Carbene Catalysts and 1,4-Naphthoquinone via Intramolecular Carbon(sp(3))-Hydrogen Bond Activation
Yuki Wada, Tsunayoshi Takehara, Takeyuki Suzuki, Satoshi Aoki, Takayuki Hibi, Makoto Sako, Hirofumi Tsujino, Yasuo Tsutsumi, Mitsuhiro Arisawa
ORGANOMETALLICS Vol. 40 No. 16 p. 2901-2908 2021年8月 研究論文（学術雑誌）
Revisiting chiral recognition mechanism on chicken alpha 1-acid glycoprotein: Location of chiral binding sites and insight into chiral binding mechanism
Jun Haginaka, Taku Yamashita, Hirofumi Tsujino, Mitsuhiro Arisawa
Separations Vol. 8 No. 6 2021年6月 研究論文（学術雑誌）
A New Bitterness Evaluation Index Obtained Using the Taste Sensor for 48 Active Pharmaceutical Ingredients of Pediatric Medicines.
Honami Kojima, Toshio Kurihara, Miyako Yoshida, Tamami Haraguchi, Haruka Nishikawa, Saeri Ikegami, Takayoshi Okuno, Taku Yamashita, Junichi Nishikawa, Hirofumi Tsujino, Mitsuhiro Arisawa, Masaaki Habara, Hidekazu Ikezaki, Takahiro Uchida
Chemical & pharmaceutical bulletin Vol. 69 No. 6 p. 537-547 2021年6月 研究論文（学術雑誌）
Inhibitory Activity and Proposed Binding Model of γ-Glutamyl Cysteine, the Precursor of Glutathione, on Angiotensin Converting Enzyme
Chisato Okajima, Naoki Imakawa, Kazuya Nagano, Masayoshi Arai, Mitsuhiro Arisawa, Misa Muraoka, Hirofumi Tsujino, Yoshihiko Hirata, Kazumasa Hirata
BPB Reports Vol. 4 No. 4 p. 116-119 2021年 研究論文（学術雑誌）
出版者・発行元：Pharmaceutical Society of Japan
Inhibition of Akt/mTOR pathway overcomes intrinsic resistance to dasatinib in triple-negative breast cancer.
Yuya Haga, Kazuma Higashisaka, Lili Yang, Naoki Sekine, Ying Lin, Hirofumi Tsujino, Kazuya Nagano, Yasuo Tsutsumi
Biochemical and biophysical research communications Vol. 533 No. 4 p. 672-678 2020年12月17日 研究論文（学術雑誌）
Impact of single nucleotide polymorphisms (R132Q and W120R) on the binding affinity and metabolic activity of CYP2C19 toward some therapeutically important substrates.
Sayed M Derayea, Hirofumi Tsujino, Yukiko Oyama, Yoshinobu Ishikawa, Taku Yamashita, Tadayuki Uno
Xenobiotica; the fate of foreign compounds in biological systems Vol. 50 No. 12 p. 1510-1519 2020年12月 研究論文（学術雑誌）
Development and Evaluation of a System for the Semi-Quantitative Determination of the Physical Properties of Skin After Exposure to Silver Nanoparticles.
Hong Tao, Kazuya Nagano, Ikkei Tasaki, Tian-Qi Zhang, Takuya Ishizaka, Jian-Qing Gao, Kazuo Harada, Kazumasa Hirata, Hirofumi Tsujino, Kazuma Higashisaka, Yasuo Tsutsumi
Nanoscale research letters Vol. 15 No. 1 p. 187-187 2020年9月29日 研究論文（学術雑誌）
Redox State Control of Human Cytoglobin by Direct Electrochemical Method to Investigate Its Function in Molecular Basis.
Yasuhiro Mie, Kyoka Takahashi, Ryo Torii, Shen Jingkai, Takumi Tanaka, Kenta Sueyoshi, Hirofumi Tsujino, Taku Yamashita
Chemical & pharmaceutical bulletin Vol. 68 No. 8 p. 806-809 2020年8月1日 研究論文（学術雑誌）
Silver Nanoparticles Induce DNA Hypomethylation through Proteasome-Mediated Degradation of DNA Methyltransferase 1.
Ayaka Maki, Ying Lin, Michihiko Aoyama, Kenta Sato, Jian-Qing Gao, Hirofumi Tsujino, Kazuya Nagano, Kazuma Higashisaka, Yasuo Tsutsumi
Biological & pharmaceutical bulletin Vol. 43 No. 12 p. 1924-1930 2020年 研究論文（学術雑誌）
Bitterness-Suppressing Effect of Umami Dipeptides and Their Constituent Amino Acids on Diphenhydramine: Evaluation by Gustatory Sensation and Taste Sensor Testing
Takayoshi Okuno, Shiori Morimoto, Haruka Nishikawa, Tamami Haraguchi, Honami Kojima, Hirofumi Tsujino, Mitsuhiro Arisawa, Taku Yamashita, Junichi Nishikawa, Miyako Yoshida, Masaaki Habara, Hidekazu Ikezaki, Takahiro Uchida
Chemical & pharmaceutical bulletin Vol. 68 No. 3 p. 234-243 2020年 研究論文（学術雑誌）
Nanoporous gold based electrodes for electrochemical studies of human neuroglobin
Yasuhiro Mie, Kyoka Takahashi, Yuka Itoga, Kenta Sueyoshi, Hirofumi Tsujino, Taku Yamashita, Tadayuki Uno
Electrochemistry Communications Vol. 110 p. 106621-106621 2020年1月 研究論文（学術雑誌）
Absorption, Fluorescence, and Two-Photon Excitation Ability of 5-Phenylisolidolo[2,1-a]quinolines
Ramon Francisco Avena, Lin Qiao, Yuki Fujii, Kohei Otomo, Hirokazu Ishii, Takeyuki Suzuki, Hirofumi Tsujino, Tadayuki Uno, Yasuo Tsutsumi, Yusuke Kawashima, Tatsuya Takagi, Kenichi Murai, Tomomi Nemoto, Mitsuhiro Arisawa
ACS Omega Vol. 5 No. 5 p. 2473-2479 2020年1月 研究論文（学術雑誌）
The role of alpha B-crystallin in chemotherapy-induced migration of triple negative breast cancer
Lili Yang, Kazuma Higashisaka, Yuya Haga, Naoki Sekine, Kotoe Kiyomoto, Ying Lin, Hirofumi Tsujino, Kazuya Nagano, Yasuo Tsutsumi
MOLECULAR CANCER THERAPEUTICS Vol. 18 No. 12 2019年12月
Development and evaluation of a simultaneous and efficient quantification strategy for final prostanoid metabolites in urine.
Zhang TQ, Kuroda H, Nagano K, Terada S, Gao JQ, Harada K, Hirata K, Tsujino H, Higashisaka K, Matsumoto H, Tsutsumi Y
Prostaglandins, leukotrienes, and essential fatty acids Vol. 157 p. 102032-102032 2019年11月 研究論文（学術雑誌）
Correlation of indoleamine-2,3-dioxigenase 1 inhibitory activity of 4,6-disubstituted indazole derivatives and their heme binding affinity.
Tsujino H, Uno T, Yamashita T, Katsuda M, Takada K, Saiki T, Maeda S, Takagi A, Masuda S, Kawano Y, Meguro K, Akai S
Bioorganic & medicinal chemistry letters Vol. 29 No. 19 p. 126607-126607 2019年10月 研究論文（学術雑誌）
Optimization and Evaluation of Pretreatment Method for sp-ICP-MS to Reveal the Distribution of Silver Nanoparticles in the Body.
Ishizaka T, Nagano K, Tasaki I, Tao H, Gao JQ, Harada K, Hirata K, Saito S, Tsujino H, Higashisaka K, Tsutsumi Y
Nanoscale research letters Vol. 14 No. 1 p. 180-180 2019年5月 研究論文（学術雑誌）
Investigation on drug-binding in heme pocket of CYP2C19 with UV-visible and resonance Raman spectroscopies.
Derayea SM, Tsujino H, Oyama Y, Ishikawa Y, Yamashita T, Uno T
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy Vol. 209 p. 209-216 2019年2月 研究論文（学術雑誌）
Direct synthesis of dialkylarylvinylsilane derivatives: Metathesis of dialkylaryl-iso-propenylsilane and its application to tetracyclic silacycle dye synthesis
Shohei Yoshioka, Tsunayoshi Takehara, Tsuyoshi Matsuzaki, Takeyuki Suzuki, Hirofumi Tsujino, Tadayuki Uno, Yasuo Tsutsumi, Kenichi Murai, Hiromichi Fujioka, Mitsuhiro Arisawa
Chemical Communications Vol. 55 No. 93 p. 14070-14073 2019年 研究論文（学術雑誌）
Effect of Drug Combination on Omeprazole Metabolism by Cytochrome P450 2C19 in Helicobacter pylori Eradication Therapy.
Attia TZ, Yamashita T, Tsujino H, Derayea SM, Tsutsumi Y, Uno T
Chemical & pharmaceutical bulletin Vol. 67 No. 8 p. 810-815 2019年 研究論文（学術雑誌）
Allosteric activation of cytochrome P450 3A4 by efavirenz facilitates midazolam binding.
Ichikawa T, Tsujino H, Miki T, Kobayashi M, Matsubara C, Miyata S, Yamashita T, Takeshita K, Yonezawa Y, Uno T
Xenobiotica; the fate of foreign compounds in biological systems Vol. 48 No. 12 p. 1227-1236 2018年12月 研究論文（学術雑誌）
Discovery of peroxisome proliferator-activated receptor α (PPARα) activators with a ligand-screening system using a human PPARα-expressing cell line.
Tachibana K, Yuzuriha T, Tabata R, Fukuda S, Maegawa T, Takahashi R, Tanimoto K, Tsujino H, Nunomura K, Lin B, Matsuura Y, Tanaka T, Hamakubo T, Sakai J, Kodama T, Kobayashi T, Ishimoto K, Miyachi H, Doi T
The Journal of biological chemistry Vol. 293 No. 26 p. 10333-10343 2018年6月 研究論文（学術雑誌）
Roles of N- and C-terminal domains in the ligand-binding properties of cytoglobin
Shumpei Hanai, Hirofumi Tsujino, Taku Yamashita, Ryo Torii, Hitomi Sawai, Yoshitsugu Shiro, Koji Oohora, Takashi Hayashi, Tadayuki Uno
Journal of Inorganic Biochemistry Vol. 179 p. 1-9 2018年2月1日 研究論文（学術雑誌）
出版者・発行元：Elsevier Inc.
Identification of claudin-4 binder that attenuates tight junction barrier function by TR-FRET-based screening assay
Akihiro Watari, Miki Kodaka, Koji Matsuhisa, Yuta Sakamoto, Kota Hisaie, Norihito Kawashita, Tatsuya Takagi, Yoshiaki Yamagishi, Hidehiko Suzuki, Hirofumi Tsujino, Kiyohito Yagi, Masuo Kondoh
SCIENTIFIC REPORTS Vol. 7 No. 1 p. 14514-14514 2017年11月 研究論文（学術雑誌）
One-pot enyne metathesis/Diels-Alder/oxidation to six-membered silacycles with a multi-ring core: Discovery of novel fluorophores
Shohei Yoshioka, Yuki Fujii, Hirofumi Tsujino, Tadayuki Uno, Hiromichi Fujioka, Mitsuhiro Arisawa
Chemical Communications Vol. 53 No. 44 p. 5970-5973 2017年 研究論文（学術雑誌）
Comparative study on stabilization mechanism of monomeric cytochrome c(5) from deep-sea piezophilic Shewanella violacea
Misa Masanari, Sotaro Fujii, Kazuki Kawahara, Hiroya Oki, Hirofumi Tsujino, Takahiro Maruno, Yuji Kobayashi, Tadayasu Ohkubo, Satoshi Wakai, Yoshihiro Sambongi
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY Vol. 80 No. 12 p. 2365-2370 2016年 研究論文（学術雑誌）
Development of an Enyne Metathesis/Isomerization/Diels-Alder One-Pot Reaction for the Synthesis of a Novel Near-Infrared (NIR) Dye Core
Kohei Yamashita, Yuki Fujii, Shohei Yoshioka, Hiroshi Aoyama, Hirofumi Tsujino, Tadayuki Uno, Hiromichi Fujioka, Mitsuhiro Arisawa
Chemistry - A European Journal Vol. 21 No. 48 p. 17491-17494 2015年11月23日 研究論文（学術雑誌）
Membrane Anchor of Cytochrome P450 Reductase Suppresses the Uncoupling of Cytochrome P450
Masayoshi Miyamoto, Taku Yamashita, Yuki Yasuhara, Akinori Hayasaki, Yukari Hosokawa, Hirofumi Tsujino, Tadayuki Uno
CHEMICAL & PHARMACEUTICAL BULLETIN Vol. 63 No. 4 p. 286-294 2015年4月 研究論文（学術雑誌）
Disulfide bonds regulate binding of exogenous ligand to human cytoglobin
Hirofumi Tsujino, Taku Yamashita, Azusa Nose, Kaori Kukino, Hitomi Sawai, Yoshitsugu Shiro, Tadayuki Uno
JOURNAL OF INORGANIC BIOCHEMISTRY Vol. 135 p. 20-27 2014年6月 研究論文（学術雑誌）
Ferric Human Neuroglobin Scavenges Superoxide to Form Oxy Adduct
Taku Yamashita, Leila Hafsi, Eri Masuda, Hirofumi Tsujino, Tadayuki Uno
CHEMICAL & PHARMACEUTICAL BULLETIN Vol. 62 No. 6 p. 613-615 2014年6月 研究論文（学術雑誌）
Effect of Cytochrome P450 2C19 and 2C9 Amino Acid Residues 72 and 241 on Metabolism of Tricyclic Antidepressant Drugs
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辻野 博文
