顔写真

PHOTO

Tsujino Hirohumi
辻野 博文
Tsujino Hirohumi
辻野 博文
Museum Links, Associate Professor

Research History 7

  1. 2023/04 - Present
    Osaka University

  2. 2020/04 - Present
    Osaka University Graduate School of Pharmaceutical Sciences

  3. 2020/04 - 2023/03
    Osaka University The Museum of Osaka University

  4. 2015/04 - 2020/03
    Osaka University Graduate School of Pharmaceutical Sciences

  5. 2014/04 - 2015/03
    Osaka University Graduate School of Pharmaceutical Sciences

  6. 2013/04 - 2014/03
    Osaka University Graduate School of Pharmaceutical Sciences

  7. 2012/04 - 2013/03
    日本学術振興会 特別研究員(DC2)

Education 3

  1. Osaka University Graduate School of Pharmaceutical Sciences

    2010/04 - 2013/03

  2. Osaka University Graduate School of Pharmaceutical Sciences

    2008/04 - 2010/03

  3. Osaka University School of Pharmaceutical Sciences

    2004/04 - 2008/03

Professional Memberships 1

  1. 日本薬学会

Research Areas 1

  1. Life sciences / Pharmaceuticals - analytical and physicochemistry /

Papers 61

  1. Electrochemical Analysis and Inhibition Assay of Immune-Modulating Enzyme, Indoleamine 2,3-Dioxygenase.

    Yasuhiro Mie, Chitose Mikami, Yoshiaki Yasutake, Yuki Shigemura, Taku Yamashita, Hirofumi Tsujino

    Pharmaceuticals (Basel, Switzerland) Vol. 18 No. 3 2025/02/28 Research paper (scientific journal)

  2. Curcumin Is Primarily Distributed in Lung, Spleen and Liver, Metabolized to Glucuronide and Sulfate, and Excreted through Bile and Urine by Using an Amorphous Curcumin Formulation with High Absorbability.

    Tomohiro Nakao, Michiko Nakamura, Kazuya Nagano, Mariko Takeda, Haruna Hirai, Hikaru Maekita, Jian-Qing Gao, Hirofumi Tsujino, Makoto Sakata, Masayuki Nishino, Yuya Haga, Kazuma Higashisaka, Yasuo Tsutsumi

    Biological & pharmaceutical bulletin Vol. 48 No. 3 p. 314-322 2025 Research paper (scientific journal)

  3. Exploring Nile Red Staining as an Analytical Tool for Surface-Oxidized Microplastics

    Wakaba Idehara, Yuya Haga, Hirofumi Tsujino, Yudai Ikuno, Sota Manabe, Mii Hokaku, Haruyasu Asahara, Kazuma Higashisaka, Yasuo Tsutsumi

    Environmental Research Vol. 269 p. 120934-120934 2025/01 Research paper (scientific journal)

    Publisher: Elsevier BV
  4. Absorption, Fluorescence, and Two-Photon Excitation Ability of 5-o-Tolyl-11 (or 13)-o-tolylisoindolo[2,1-a]quinolines Prepared by Ring-Closing Metathesis and [2+3] Cycloaddition.

    Yuki Wada, Kwangkyun Jang, Hirokazu Ishii, Yuki Watakabe, Motosuke Tsutsumi, Makoto Sako, Tsunayoshi Takehara, Takeyuki Suzuki, Hirofumi Tsujino, Yasuo Tsutsumi, Tomomi Nemoto, Mitsuhiro Arisawa

    Chemistry, an Asian journal Vol. 20 No. 2 2024/11/04 Research paper (scientific journal)

  5. Treatment of polyethylene microplastics degraded by ultraviolet light irradiation causes lysosome-deregulated cell death

    Sota Manabe, Yuya Haga, Hirofumi Tsujino, Yudai Ikuno, Haruyasu Asahara, Kazuma Higashisaka, Yasuo Tsutsumi

    Scientific Reports Vol. 14 No. 1 p. 24008-24008 2024/10/14 Research paper (scientific journal)

    Publisher: Springer Science and Business Media LLC
  6. Polyethylene, whose surface has been modified by UV irradiation, induces cytotoxicity: A comparison with microplastics found in beaches.

    Yudai Ikuno, Hirofumi Tsujino, Yuya Haga, Sota Manabe, Wakaba Idehara, Mii Hokaku, Haruyasu Asahara, Kazuma Higashisaka, Yasuo Tsutsumi

    Ecotoxicology and environmental safety Vol. 277 p. 116346-116346 2024/06/01 Research paper (scientific journal)

  7. Furanyl bis(indolyl)methane as a palladium ion-selective chromogenic agent.

    Kazuho Ban, Shiho Nozaki, Takaaki Aijima, Shuki Oyama, Hirofumi Tsujino, Yusuke Kanematsu, Shuji Akai, Yoshinari Sawama

    Organic & biomolecular chemistry Vol. 22 No. 14 p. 2734-2738 2024/04/03 Research paper (scientific journal)

  8. Coculture with macrophages alters ferroptosis susceptibility of triple-negative cancer cells

    Hiroto Konishi, Yuya Haga, Moe Okumura, Hirofumi Tsujino, Kazuma Higashisaka, Yasuo Tsutsumi

    Cell Death Discovery Vol. 10 No. 1 p. 108-108 2024/03/01 Research paper (scientific journal)

    Publisher: Springer Science and Business Media LLC
  9. Polyglycerol fatty acid ester contributes to the improvement and maintenance of water solubility of amorphous curcumin by suppressing the intermolecular interaction and the diffusion rate of curcumin

    Kazuya Nagano, Tomohiro Nakao, Mariko Takeda, Haruna Hirai, Hikaru Maekita, Michiko Nakamura, Naoki Imakawa, Ayako Egawa, Toshimichi Fujiwara, Jian-Qing Gao, Keigo Kinoshita, Makoto Sakata, Masayuki Nishino, Takuya Yamashita, Takuya Yoshida, Kazuo Harada, Keisuke Tachibana, Takefumi Doi, Kazumasa Hirata, Hirofumi Tsujino, Kazuma Higashisaka, Yasuo Tsutsumi

    Food Chemistry Vol. 437 No. Pt 2 p. 137866-137866 2024/03 Research paper (scientific journal)

    Publisher: Elsevier BV
  10. 劣化したマイクロプラスチックが示す細胞毒性機序の解明

    Yuya Haga, Sota Manabe, Hirofumi Tsujino, Haruyasu Asahara, Kazuma Higashisaka, Yasuo Tsutsumi

    YAKUGAKU ZASSHI Vol. 144 No. 2 p. 177-181 2024/02/01 Research paper (scientific journal)

    Publisher: Pharmaceutical Society of Japan
  11. 環境中の表面性状を模倣した劣化マイクロプラスチックの作製

    Hirofumi Tsujino, Yudai Ikuno, Yuya Haga, Haruyasu Asahara, Kazuma Higashisaka, Yasuo Tsutsumi

    YAKUGAKU ZASSHI Vol. 144 No. 2 p. 171-175 2024/02/01 Research paper (scientific journal)

    Publisher: Pharmaceutical Society of Japan
  12. The Lower Toxicity and Wider Safety Range of Acidic Sophorolipid Compared to Surfactin and Rhamnolipid as Biosurfactants toward the HaCAT, THP-1, and RAW 264.7

    Michiaki Araki, Erika Kunimi, Yoshihiko Hirata, Misa Muraoka, Hirofumi Tsujino, Masayoshi Arai, Kazumasa Hirata, Kazuya Nagano

    BPB Reports Vol. 7 No. 2 p. 56-60 2024 Research paper (scientific journal)

    Publisher: Pharmaceutical Society of Japan
  13. [Toward Elucidation of Human Health Effects of Micro/nanoplastics].

    Yasuo Tsutsumi, Hirofumi Tsujino

    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan Vol. 144 No. 2 p. 163-164 2024 Research paper (scientific journal)

  14. Valproic acid elevates HIF-1α-mediated CGB expression and suppresses glucose uptake in BeWo cells.

    Go Kitahara, Kazuma Higashisaka, Yurina Nakamoto, Rena Yamamoto, Wakako Okuno, Momoe Serizawa, Yuji Sakahashi, Hirofumi Tsujino, Yuya Haga, Yasuo Tsutsumi

    The Journal of toxicological sciences Vol. 49 No. 2 p. 69-77 2024 Research paper (scientific journal)

  15. Impact of multiple H/D replacements on the physicochemical properties of flurbiprofen.

    Hiromasa Uchiyama, Kazuho Ban, Shiho Nozaki, Yui Ikeda, Takayoshi Ishimoto, Hiroyoshi Fujioka, Mako Kamiya, Ryugo Amari, Hirofumi Tsujino, Masayoshi Arai, Sachi Yamazoe, Keiko Maekawa, Takuma Kato, Mitsunobu Doi, Kazunori Kadota, Yuichi Tozuka, Naohito Tomita, Hironao Sajiki, Shuji Akai, Yoshinari Sawama

    RSC medicinal chemistry Vol. 14 No. 12 p. 2583-2592 2023/12/13 Research paper (scientific journal)

  16. Impact of Degradation of Polyethylene Particles on Their Cytotoxicity

    Yudai Ikuno, Hirofumi Tsujino, Yuya Haga, Haruyasu Asahara, Kazuma Higashisaka, Yasuo Tsutsumi

    Microplastics Vol. 2 No. 2 p. 192-201 2023/05/22 Research paper (scientific journal)

    Publisher: MDPI AG
  17. Fluorouracil exacerbates alpha-crystallin B chain-mediated cell migration in triple-negative breast cancer cell lines.

    Lili Yang, Yuya Haga, Akihide Nishimura, Yuki Tsujii, Suzuno Tanahashi, Hirofumi Tsujino, Kazuma Higashisaka, Yasuo Tsutsumi

    Scientific reports Vol. 13 No. 1 p. 4010-4010 2023/03/10 Research paper (scientific journal)

  18. Silver nanoparticles suppress forskolin-induced syncytialization in BeWo cells

    Yuji Sakahashi, Kazuma Higashisaka, Ryo Isaka, Rina Izutani, Jiwon Seo, Atsushi Furuta, Akemi Yamaki-Ushijima, Hirofumi Tsujino, Yuya Haga, Akitoshi Nakashima, Yasuo Tsutsumi

    Nanotoxicology Vol. 16 No. 9-10 p. 1-12 2023/01/03 Research paper (scientific journal)

    Publisher: Informa UK Limited
  19. Effect of benzopyrene-induced cellular senescence on cancer malignant change

    KITAMOTO Natsuko, HAGA Yuya, TSUJII Yuki, TSUJINO Hirofumi, HIGASHISAKA Kazuma, TSUTSUMI Yasuo

    Annual Meeting of the Japanese Society of Toxicology Vol. 50.1 2023

    Publisher: The Japanese Society of Toxicology
  20. Absorption, fluorescence, and two-photon excitation ability of 5-phenyl-13-arylisoindolo[2,1-a]quinolines prepared by one-pot reaction of ring-closing metathesis and 1,3-dipolar cycloaddition

    Avena Francisco Ramon, Yuki Wada, Hirokazu Ishii, Yuki Watakabe, Motosuke Tsutsumi, Kwangkyun Jang, Kohei Otomo, Lin Qiao, Yuki Fujii, Hirofumi Tsujino, Yasuo Tsutsumi, Tomomi Nemoto, Mitsuhiro Arisawa

    Dyes and Pigments p. 111118-111118 2023/01 Research paper (scientific journal)

    Publisher: Elsevier BV
  21. Silver Nanoparticles Suppress Retinoic Acid-Induced Neuronal Differentiation in Human-Derived Neuroblastoma SH-SY5Y Cells

    Shintaro Yamaguchi, Ryo Isaka, Yuji Sakahashi, Hirofumi Tsujino, Yuya Haga, Kazuma Higashisaka, Yasuo Tsutsumi

    ACS Applied Nano Materials Vol. 5 No. 12 p. 19025-19034 2022/12/23 Research paper (scientific journal)

    Publisher: American Chemical Society (ACS)
  22. Osimertinib-tolerant lung cancer cells are susceptible to ferroptosis.

    Hiroto Konishi, Yuya Haga, Ying Lin, Hirofumi Tsujino, Kazuma Higashisaka, Yasuo Tsutsumi

    Biochemical and biophysical research communications Vol. 641 p. 116-122 2022/12/10 Research paper (scientific journal)

  23. Amorphous silica nanoparticles (nSP50) exacerbate hepatic damage through the activation of acquired cell-mediated immunity

    Shun-ichi Eto, Kazuma Higashisaka, Aoi Koshida, Kenta Sato, Mao Ogura, Miyuki Sakurai, Hirofumi Tsujino, Kazuya Nagano, Yasuo Tsutsumi

    Nano Express Vol. 3 No. 1 p. 015002-015002 2022/03/01 Research paper (scientific journal)

    Publisher: IOP Publishing
  24. Alpha-crystallin B chains enhance cell migration in basal-like 2 triple-negative breast cancer cells

    L. Yang, K. Higashisaka, Y. Haga, H. Tsujino, K. Nagano, Y. Tsutsumi

    PHARMAZIE Vol. 77 No. 2 2022/02 Research paper (scientific journal)

  25. Identification of biomarkers of chronic kidney disease among kidney-derived proteins.

    Kazuma Higashisaka, Sonoko Takeya, Haruhiko Kamada, Masanori Obana, Makiko Maeda, Mai Kabayama, Koichi Yamamoto, Nanan Ishida, Ryo Isaka, Hirofumi Tsujino, Kazuya Nagano, Noriyuki Tomiyama, Hiromi Rakugi, Yasushi Fujio, Kei Kamide, Yasuo Tsutsumi

    Clinical proteomics Vol. 19 No. 1 p. 3-3 2022/01/11 Research paper (scientific journal)

  26. Amorphas Silica Nanoparticles Decrease Human Chorionic Gonadotropin β Expression During Syncytialization of BeWo Cell

    Yuji Sakahashi, Rena Yamamoto, Go Kitahara, Rina Izutani, Hirofumi Tsujino, Yuya Haga, Kazuma Higashisaka, Yasuo Tsutsumi

    BPB Reports Vol. 5 No. 6 p. 154-158 2022 Research paper (scientific journal)

    Publisher: Pharmaceutical Society of Japan
  27. Silica Particles with Human Protein Corona Shows Sensitization Potential in the Human Cell Line Activation Test

    Shun-ichi Eto, Aoi Koshida, Hirofumi Tsujino, Kazuya Nagano, Kazuma Higashisaka, Yasuo Tsutsumi

    BPB Reports Vol. 5 No. 1 p. 1-4 2022 Research paper (scientific journal)

    Publisher: Pharmaceutical Society of Japan
  28. Subvisible Particles Derived by Dropping Stress Enhance Anti-PEG Antibody Production and Clearance of PEGylated Proteins in Mice

    Takaki Nakajima, Kazuya Nagano, Yuka Fukuda, Yu Ishima, Hiroko Shibata, Ryo Isaka, Tian-qi Zhang, Yuya Haga, Kazuma Higashisaka, Hirofumi Tsujino, Tatsuhiro Ishida, Akiko Ishii-Watabe, Yasuo Tsutsumi

    Journal of Pharmaceutical Sciences Vol. 111 No. 5 p. 1363-1369 2022/01 Research paper (scientific journal)

    Publisher: Elsevier BV
  29. Alpha-crystallin B chains in trastuzumab-resistant breast cancer cells promote endothelial cell tube formation through activating mTOR

    Lili Yang, Kazuma Higashisaka, Masafumi Shimoda, Yuya Haga, Naoki Sekine, Hirofumi Tsujino, Kazuya Nagano, Kenzo Shimazu, Yasuo Tsutsumi

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Vol. 588 p. 175-181 2022/01 Research paper (scientific journal)

  30. Indoxyl Sulfate Induces an Inflammatory Response in the Proximal Tubule via Macrophages

    Isaka R, Ishida N, Kitahara G, Sakahashi Y, Haga Y, Tsujino H, Nagano K, Higashisaka K, Tsutsumi Y

    BPB Reports Vol. 4 No. 6 p. 198-201 2021/11 Research paper (scientific journal)

    Publisher: Pharmaceutical Society of Japan
  31. Carbon-Carbon Bond Formation between N-Heterocyclic Carbene Ligand on Ruthenium Carbene Catalysts and 1,4-Naphthoquinone via Intramolecular Carbon(sp(3))-Hydrogen Bond Activation

    Yuki Wada, Tsunayoshi Takehara, Takeyuki Suzuki, Satoshi Aoki, Takayuki Hibi, Makoto Sako, Hirofumi Tsujino, Yasuo Tsutsumi, Mitsuhiro Arisawa

    ORGANOMETALLICS Vol. 40 No. 16 p. 2901-2908 2021/08 Research paper (scientific journal)

  32. Revisiting chiral recognition mechanism on chicken alpha 1-acid glycoprotein: Location of chiral binding sites and insight into chiral binding mechanism

    Jun Haginaka, Taku Yamashita, Hirofumi Tsujino, Mitsuhiro Arisawa

    Separations Vol. 8 No. 6 2021/06 Research paper (scientific journal)

  33. A New Bitterness Evaluation Index Obtained Using the Taste Sensor for 48 Active Pharmaceutical Ingredients of Pediatric Medicines.

    Honami Kojima, Toshio Kurihara, Miyako Yoshida, Tamami Haraguchi, Haruka Nishikawa, Saeri Ikegami, Takayoshi Okuno, Taku Yamashita, Junichi Nishikawa, Hirofumi Tsujino, Mitsuhiro Arisawa, Masaaki Habara, Hidekazu Ikezaki, Takahiro Uchida

    Chemical & pharmaceutical bulletin Vol. 69 No. 6 p. 537-547 2021/06 Research paper (scientific journal)

  34. Inhibitory Activity and Proposed Binding Model of γ-Glutamyl Cysteine, the Precursor of Glutathione, on Angiotensin Converting Enzyme

    Chisato Okajima, Naoki Imakawa, Kazuya Nagano, Masayoshi Arai, Mitsuhiro Arisawa, Misa Muraoka, Hirofumi Tsujino, Yoshihiko Hirata, Kazumasa Hirata

    BPB Reports Vol. 4 No. 4 p. 116-119 2021 Research paper (scientific journal)

    Publisher: Pharmaceutical Society of Japan
  35. Inhibition of Akt/mTOR pathway overcomes intrinsic resistance to dasatinib in triple-negative breast cancer.

    Yuya Haga, Kazuma Higashisaka, Lili Yang, Naoki Sekine, Ying Lin, Hirofumi Tsujino, Kazuya Nagano, Yasuo Tsutsumi

    Biochemical and biophysical research communications Vol. 533 No. 4 p. 672-678 2020/12/17 Research paper (scientific journal)

  36. Impact of single nucleotide polymorphisms (R132Q and W120R) on the binding affinity and metabolic activity of CYP2C19 toward some therapeutically important substrates.

    Sayed M Derayea, Hirofumi Tsujino, Yukiko Oyama, Yoshinobu Ishikawa, Taku Yamashita, Tadayuki Uno

    Xenobiotica; the fate of foreign compounds in biological systems Vol. 50 No. 12 p. 1510-1519 2020/12 Research paper (scientific journal)

  37. Development and Evaluation of a System for the Semi-Quantitative Determination of the Physical Properties of Skin After Exposure to Silver Nanoparticles.

    Hong Tao, Kazuya Nagano, Ikkei Tasaki, Tian-Qi Zhang, Takuya Ishizaka, Jian-Qing Gao, Kazuo Harada, Kazumasa Hirata, Hirofumi Tsujino, Kazuma Higashisaka, Yasuo Tsutsumi

    Nanoscale research letters Vol. 15 No. 1 p. 187-187 2020/09/29 Research paper (scientific journal)

  38. Redox State Control of Human Cytoglobin by Direct Electrochemical Method to Investigate Its Function in Molecular Basis.

    Yasuhiro Mie, Kyoka Takahashi, Ryo Torii, Shen Jingkai, Takumi Tanaka, Kenta Sueyoshi, Hirofumi Tsujino, Taku Yamashita

    Chemical & pharmaceutical bulletin Vol. 68 No. 8 p. 806-809 2020/08/01 Research paper (scientific journal)

  39. Silver Nanoparticles Induce DNA Hypomethylation through Proteasome-Mediated Degradation of DNA Methyltransferase 1.

    Ayaka Maki, Ying Lin, Michihiko Aoyama, Kenta Sato, Jian-Qing Gao, Hirofumi Tsujino, Kazuya Nagano, Kazuma Higashisaka, Yasuo Tsutsumi

    Biological & pharmaceutical bulletin Vol. 43 No. 12 p. 1924-1930 2020 Research paper (scientific journal)

  40. Bitterness-Suppressing Effect of Umami Dipeptides and Their Constituent Amino Acids on Diphenhydramine: Evaluation by Gustatory Sensation and Taste Sensor Testing

    Takayoshi Okuno, Shiori Morimoto, Haruka Nishikawa, Tamami Haraguchi, Honami Kojima, Hirofumi Tsujino, Mitsuhiro Arisawa, Taku Yamashita, Junichi Nishikawa, Miyako Yoshida, Masaaki Habara, Hidekazu Ikezaki, Takahiro Uchida

    Chemical & pharmaceutical bulletin Vol. 68 No. 3 p. 234-243 2020 Research paper (scientific journal)

  41. Nanoporous gold based electrodes for electrochemical studies of human neuroglobin

    Yasuhiro Mie, Kyoka Takahashi, Yuka Itoga, Kenta Sueyoshi, Hirofumi Tsujino, Taku Yamashita, Tadayuki Uno

    Electrochemistry Communications Vol. 110 p. 106621-106621 2020/01 Research paper (scientific journal)

  42. Absorption, Fluorescence, and Two-Photon Excitation Ability of 5-Phenylisolidolo[2,1-a]quinolines

    Ramon Francisco Avena, Lin Qiao, Yuki Fujii, Kohei Otomo, Hirokazu Ishii, Takeyuki Suzuki, Hirofumi Tsujino, Tadayuki Uno, Yasuo Tsutsumi, Yusuke Kawashima, Tatsuya Takagi, Kenichi Murai, Tomomi Nemoto, Mitsuhiro Arisawa

    ACS Omega Vol. 5 No. 5 p. 2473-2479 2020/01 Research paper (scientific journal)

  43. The role of alpha B-crystallin in chemotherapy-induced migration of triple negative breast cancer

    Lili Yang, Kazuma Higashisaka, Yuya Haga, Naoki Sekine, Kotoe Kiyomoto, Ying Lin, Hirofumi Tsujino, Kazuya Nagano, Yasuo Tsutsumi

    MOLECULAR CANCER THERAPEUTICS Vol. 18 No. 12 2019/12

  44. Development and evaluation of a simultaneous and efficient quantification strategy for final prostanoid metabolites in urine.

    Zhang TQ, Kuroda H, Nagano K, Terada S, Gao JQ, Harada K, Hirata K, Tsujino H, Higashisaka K, Matsumoto H, Tsutsumi Y

    Prostaglandins, leukotrienes, and essential fatty acids Vol. 157 p. 102032-102032 2019/11 Research paper (scientific journal)

  45. Correlation of indoleamine-2,3-dioxigenase 1 inhibitory activity of 4,6-disubstituted indazole derivatives and their heme binding affinity.

    Tsujino H, Uno T, Yamashita T, Katsuda M, Takada K, Saiki T, Maeda S, Takagi A, Masuda S, Kawano Y, Meguro K, Akai S

    Bioorganic & medicinal chemistry letters Vol. 29 No. 19 p. 126607-126607 2019/10 Research paper (scientific journal)

  46. Optimization and Evaluation of Pretreatment Method for sp-ICP-MS to Reveal the Distribution of Silver Nanoparticles in the Body.

    Ishizaka T, Nagano K, Tasaki I, Tao H, Gao JQ, Harada K, Hirata K, Saito S, Tsujino H, Higashisaka K, Tsutsumi Y

    Nanoscale research letters Vol. 14 No. 1 p. 180-180 2019/05 Research paper (scientific journal)

  47. Investigation on drug-binding in heme pocket of CYP2C19 with UV-visible and resonance Raman spectroscopies.

    Derayea SM, Tsujino H, Oyama Y, Ishikawa Y, Yamashita T, Uno T

    Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy Vol. 209 p. 209-216 2019/02 Research paper (scientific journal)

  48. Direct synthesis of dialkylarylvinylsilane derivatives: Metathesis of dialkylaryl-iso-propenylsilane and its application to tetracyclic silacycle dye synthesis

    Shohei Yoshioka, Tsunayoshi Takehara, Tsuyoshi Matsuzaki, Takeyuki Suzuki, Hirofumi Tsujino, Tadayuki Uno, Yasuo Tsutsumi, Kenichi Murai, Hiromichi Fujioka, Mitsuhiro Arisawa

    Chemical Communications Vol. 55 No. 93 p. 14070-14073 2019 Research paper (scientific journal)

  49. Effect of Drug Combination on Omeprazole Metabolism by Cytochrome P450 2C19 in Helicobacter pylori Eradication Therapy.

    Attia TZ, Yamashita T, Tsujino H, Derayea SM, Tsutsumi Y, Uno T

    Chemical & pharmaceutical bulletin Vol. 67 No. 8 p. 810-815 2019 Research paper (scientific journal)

  50. Allosteric activation of cytochrome P450 3A4 by efavirenz facilitates midazolam binding.

    Ichikawa T, Tsujino H, Miki T, Kobayashi M, Matsubara C, Miyata S, Yamashita T, Takeshita K, Yonezawa Y, Uno T

    Xenobiotica; the fate of foreign compounds in biological systems Vol. 48 No. 12 p. 1227-1236 2018/12 Research paper (scientific journal)

  51. Discovery of peroxisome proliferator-activated receptor α (PPARα) activators with a ligand-screening system using a human PPARα-expressing cell line.

    Tachibana K, Yuzuriha T, Tabata R, Fukuda S, Maegawa T, Takahashi R, Tanimoto K, Tsujino H, Nunomura K, Lin B, Matsuura Y, Tanaka T, Hamakubo T, Sakai J, Kodama T, Kobayashi T, Ishimoto K, Miyachi H, Doi T

    The Journal of biological chemistry Vol. 293 No. 26 p. 10333-10343 2018/06 Research paper (scientific journal)

  52. Roles of N- and C-terminal domains in the ligand-binding properties of cytoglobin

    Shumpei Hanai, Hirofumi Tsujino, Taku Yamashita, Ryo Torii, Hitomi Sawai, Yoshitsugu Shiro, Koji Oohora, Takashi Hayashi, Tadayuki Uno

    Journal of Inorganic Biochemistry Vol. 179 p. 1-9 2018/02/01 Research paper (scientific journal)

    Publisher: Elsevier Inc.
  53. Identification of claudin-4 binder that attenuates tight junction barrier function by TR-FRET-based screening assay

    Akihiro Watari, Miki Kodaka, Koji Matsuhisa, Yuta Sakamoto, Kota Hisaie, Norihito Kawashita, Tatsuya Takagi, Yoshiaki Yamagishi, Hidehiko Suzuki, Hirofumi Tsujino, Kiyohito Yagi, Masuo Kondoh

    SCIENTIFIC REPORTS Vol. 7 No. 1 p. 14514-14514 2017/11 Research paper (scientific journal)

  54. One-pot enyne metathesis/Diels-Alder/oxidation to six-membered silacycles with a multi-ring core: Discovery of novel fluorophores

    Shohei Yoshioka, Yuki Fujii, Hirofumi Tsujino, Tadayuki Uno, Hiromichi Fujioka, Mitsuhiro Arisawa

    Chemical Communications Vol. 53 No. 44 p. 5970-5973 2017 Research paper (scientific journal)

  55. Comparative study on stabilization mechanism of monomeric cytochrome c(5) from deep-sea piezophilic Shewanella violacea

    Misa Masanari, Sotaro Fujii, Kazuki Kawahara, Hiroya Oki, Hirofumi Tsujino, Takahiro Maruno, Yuji Kobayashi, Tadayasu Ohkubo, Satoshi Wakai, Yoshihiro Sambongi

    BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY Vol. 80 No. 12 p. 2365-2370 2016 Research paper (scientific journal)

  56. Development of an Enyne Metathesis/Isomerization/Diels-Alder One-Pot Reaction for the Synthesis of a Novel Near-Infrared (NIR) Dye Core

    Kohei Yamashita, Yuki Fujii, Shohei Yoshioka, Hiroshi Aoyama, Hirofumi Tsujino, Tadayuki Uno, Hiromichi Fujioka, Mitsuhiro Arisawa

    Chemistry - A European Journal Vol. 21 No. 48 p. 17491-17494 2015/11/23 Research paper (scientific journal)

  57. Membrane Anchor of Cytochrome P450 Reductase Suppresses the Uncoupling of Cytochrome P450

    Masayoshi Miyamoto, Taku Yamashita, Yuki Yasuhara, Akinori Hayasaki, Yukari Hosokawa, Hirofumi Tsujino, Tadayuki Uno

    CHEMICAL & PHARMACEUTICAL BULLETIN Vol. 63 No. 4 p. 286-294 2015/04 Research paper (scientific journal)

  58. Disulfide bonds regulate binding of exogenous ligand to human cytoglobin

    Hirofumi Tsujino, Taku Yamashita, Azusa Nose, Kaori Kukino, Hitomi Sawai, Yoshitsugu Shiro, Tadayuki Uno

    JOURNAL OF INORGANIC BIOCHEMISTRY Vol. 135 p. 20-27 2014/06 Research paper (scientific journal)

  59. Ferric Human Neuroglobin Scavenges Superoxide to Form Oxy Adduct

    Taku Yamashita, Leila Hafsi, Eri Masuda, Hirofumi Tsujino, Tadayuki Uno

    CHEMICAL & PHARMACEUTICAL BULLETIN Vol. 62 No. 6 p. 613-615 2014/06 Research paper (scientific journal)

  60. Effect of Cytochrome P450 2C19 and 2C9 Amino Acid Residues 72 and 241 on Metabolism of Tricyclic Antidepressant Drugs

    Tamer Zekry Attia, Taku Yamashita, Mohamed Abdelkhalek Hammad, Akinori Hayasaki, Takumi Sato, Masayoshi Miyamoto, Yuki Yasuhara, Takashi Nakamura, Yusuke Kagawa, Hirofumi Tsujino, Mahmoud Ahmed Omar, Osama Hassan Abdelmageed, Sayed Mohamed Derayea, Tadayuki Uno

    CHEMICAL & PHARMACEUTICAL BULLETIN Vol. 62 No. 2 p. 176-181 2014/02 Research paper (scientific journal)

  61. Creation and biochemical analysis of a broad-specific claudin binder

    Azusa Takahashi, Yumiko Saito, Masuo Kondoh, Kyohei Matsushita, Susanne M. Krug, Hidehiko Suzuki, Hirofumi Tsujino, Xiangru Li, Hiroshi Aoyama, Koji Matsuhisa, Tadayuki Uno, Michael Fromm, Takao Hamakubo, Kiyohito Yagi

    BIOMATERIALS Vol. 33 No. 12 p. 3464-3474 2012/04 Research paper (scientific journal)

Misc. 8

  1. 微粒子曝露と脆弱な世代への健康影響 : 胎盤毒性/動態解析を例に—Health effects of fine particle exposure on vulnerable generations

    東阪 和馬, 芳賀 優弥, 辻野 博文, 堤 康央

    Bio clinica = バイオクリニカ Vol. 37 No. 1 p. 61-65 2022/01

    Publisher: 東京 : 北隆館
  2. The effect of cellular senescence caused by benzopyrene on cancer progression.

    北本夏子, 芳賀優弥, 辻井勇気, 辻野博文, 辻野博文, 東阪和馬, 東阪和馬, 堤康央, 堤康央

    日本薬学会年会要旨集(Web) Vol. 142nd 2022

  3. Progesterone receptor membrane component 1 leads to erlotinib resistance, initiating crosstalk of Wnt/β-catenin and NF-κB pathways, in lung adenocarcinoma cells.

    Ying Lin, Kazuma Higashisaka, Takuya Shintani, Ayaka Maki, Sachiyo Hanamuro, Yuya Haga, Shinichiro Maeda, Hirofumi Tsujino, Kazuya Nagano, Yasushi Fujio, Yasuo Tsutsumi

    Scientific reports Vol. 10 No. 1 p. 4748-4748 2020/03/16

  4. 近位尿細管の上皮間葉転換においてインテグリンリガンドが果たす役割の解明

    井阪 亮, 東阪 和馬, 石田 菜南, 坂橋 優治, 山口 慎太郎, 北原 剛, 藤尾 慈, 神出 計, 辻野 博文, 長野 一也, 堤 康央

    日本薬学会年会要旨集 Vol. 140年会 p. 26F-pm11S 2020/03

    Publisher: (公社)日本薬学会
  5. Preparation of a broad-specific claudin binder by using Clostridium perfringens enterotoxin

    Hidehiko Suzuki, Azusa Takahashi, Kyohei Matsushita, Xiangru Li, Hirofumi Tsujino, Akihiro Watari, Masuo Kondoh, Hiroshi Aoyama, Tadayuki Uno, Kiyohito Yagi

    FASEB JOURNAL Vol. 26 2012/04 Research paper, summary (international conference)

  6. Structural and biochemical analysis of a novel, broadly specific claudin binder.

    S. Nagase, K. Matsushita, A. Takahashi, H. Tsujino, X. Li, H. Suzuki, H. Aoyama, M. Kondoh, A. Watari, T. Uno, T. Hamakubo, K. Yagi

    MOLECULAR BIOLOGY OF THE CELL Vol. 23 2012 Research paper, summary (international conference)

  7. Correlations between ligand binding properties and redox states of haem and disulphide bond in neuroglobin

    Leila Hafsi, Hirofumi Tsujino, Taku Yamashita, Hiroshi Aoyama, Tadayuki Uno

    AIP Conference Proceedings Vol. 1267 p. 879-880 2010/12/14

  8. Hydrophobic residues regulate distal histidine coordinations in human Cgb and Ngb

    Hirofumi Tsujino, Taku Yamashita, Leila Hafsi, Azusa Nose, Kaori Kukino, Norifumi Kawada, Katsutoshi Yoshizato, Yoshitsugu Shiro, Hiroshi Aoyama, Tadayuki Uno

    AIP Conference Proceedings Vol. 1267 p. 877-878 2010/12/14

Academic Activities 2

  1. 大阪大学総合学術博物館 第20回特別展 トヨナカ写真/マチの肖像 1950-2000

    大阪大学総合学術博物館

    2024/07/17 - 2024/08/17

  2. 大阪大学総合学術博物館 第16回特別展「モダン中之島コレクション “大大阪”時代の文化芸術発信センター」

    大阪大学総合学術博物館

    2022/04/28 - 2022/07/30

Institutional Repository 7

Content Published in the University of Osaka Institutional Repository (OUKA)
  1. Exploring Nile Red staining as an analytical tool for surface-oxidized microplastics

    Idehara Wakaba, Haga Yuya, Tsujino Hirofumi, Ikuno Yudai, Manabe Sota, Hokaku Mii, Asahara Haruyasu, Higashisaka Kazuma, Tsutsumi Yasuo

    Environmental Research Vol. 269 2025/03/15

  2. Absorption, Fluorescence, and Two-Photon Excitation Ability of 5-o-Tolyl-11 (or 13)-o-tolylisoindolo[2,1-a]quinolines Prepared by Ring-Closing Metathesis and [2+3] Cycloaddition

    Wada Yuki, Jang Kwangkyun, Ishii Hirokazu, Watakabe Yuki, Tsutsumi Motosuke, Sako Makoto, Takehara Tsunayoshi, Suzuki Takeyuki, Tsujino Hirofumi, Tsutsumi Yasuo, Nemoto Tomomi, Arisawa Mitsuhiro

    Chemistry - An Asian Journal Vol. 20 No. 2 2025/01/17

  3. Treatment of polyethylene microplastics degraded by ultraviolet light irradiation causes lysosome-deregulated cell death

    Manabe Sota, Haga Yuya, Tsujino Hirofumi, Ikuno Yudai, Asahara Haruyasu, Higashisaka Kazuma, Tsutsumi Yasuo

    Scientific Reports Vol. 14 2024/10/14

  4. Polyethylene, whose surface has been modified by UV irradiation, induces cytotoxicity: A comparison with microplastics found in beaches

    Ikuno Yudai, Tsujino Hirofumi, Haga Yuya, Manabe Sota, Idehara Wakaba, Hokaku Mii, Asahara Haruyasu, Higashisaka Kazuma, Tsutsumi Yasuo

    Ecotoxicology and Environmental Safety Vol. 277 2024/06/01

  5. Coculture with macrophages alters ferroptosis susceptibility of triple-negative cancer cells

    Konishi Hiroto, Haga Yuya, Okumura Moe, Tsujino Hirofumi, Higashisaka Kazuma, Tsutsumi Yasuo

    Cell Death Discovery Vol. 10 No. 1 2024/03/01

  6. Furanyl bis(indolyl)methane as a palladium ion-selective chromogenic agent

    Ban Kazuho, Nozaki Shiho, Aijima Takaaki, Oyama Shuki, Tsujino Hirofumi, Kanematsu Yusuke, Akai Shuji, Sawama Yoshinari

    Organic and Biomolecular Chemistry Vol. 22 No. 14 p. 2734-2738 2024/02/09

  7. サイトグロビンの多量体形成による活性酸素種との反応性制御

    辻野 博文