EN

基本情報

研究

社会活動

その他の活動

島村 宗尚

Shimamura Munehisa

医学系研究科,寄附講座准教授

keyword 神経内科,脳梗塞,認知症,パーキンソン病,遺伝子治療,ワクチン,ペプチド創薬

学歴

  • 2003年06月 ~ 2005年03月,国立循環器病センター,放射線医学部 任意研修生
  • 2001年04月 ~ 2005年03月,大阪大学大学院,医学系研究科遺伝子治療学(大学院生)
  • 1991年04月 ~ 1997年03月,熊本大学,医学部
  • ~ 1991年03月,熊本県立熊本高等学校

経歴

  • 2015年04月 ~ 継続中,大阪大学大学院医学系研究科,健康発達医学講座,寄附講座准教授
  • 2014年07月 ~ 継続中,大阪大学大学院医学系研究科,神経内科学,(併任)
  • 2010年04月 ~ 2015年03月,大阪大学大学院連合小児発達学研究科,健康発達医学講座,寄附講座准教授
  • 2009年05月 ~ 2010年03月,大阪大学大学院医学系研究科,老年・腎臓内科学,特任助教
  • 2007年04月 ~ 2009年05月,コーネル大学医学部,神経生物学,リサーチフェロー
  • 2005年04月 ~ 2007年03月,東京大学大学院医学系研究科,先端臨床医学開発講座,助手
  • 2000年04月 ~ 2001年03月,熊本大学医学部附属病院,神経内科,医員
  • 1999年04月 ~ 2000年03月,熊本市立市民病院,神経内科,医員
  • 1998年04月 ~ 1999年03月,熊本大学医学部附属病院,神経内科,研修医
  • 1997年10月 ~ 1998年03月,済生会熊本病院循環器内科,研修医
  • 1997年04月 ~ 1997年09月,熊本大学医学部附属病院,神経内科,研修医

研究内容・専門分野

  • ライフサイエンス,神経内科学

論文

  • A novel angiotensin II peptide vaccine without an adjuvant in mice.,Ryo Nakamaru,Hironori Nakagami,Hiroki Hayashi,Jiao Sun,Akiko Tenma,Koichi Yamamoto,Munehisa Shimamura,Ryuichi Morishita,Hiromi Rakugi,Journal of hypertension,Vol. 39,No. 1,p. 181-189,2021年01月,研究論文(学術雑誌)
  • The CD153 vaccine is a senotherapeutic option for preventing the accumulation of senescent T cells in mice,Shota Yoshida,Hironori Nakagami,Hiroki Hayashi,Yuka Ikeda,Jiao Sun,Akiko Tenma,Hideki Tomioka,Tomohiro Kawano,Munehisa Shimamura,Ryuichi Morishita,Hiromi Rakugi,Nature Communications,Springer Science and Business Media LLC,Vol. 11,No. 1,2020年12月,研究論文(学術雑誌)
  • Go-sha-jinki-Gan Alleviates Inflammation in Neurological Disorders via p38-TNF Signaling in the Central Nervous System,Shiying Jiang,Kousuke Baba,Tatsusada Okuno,Makoto Kinoshita,Chi-Jing Choong,Hideki Hayakawa,Hiroshi Sakiyama,Kensuke Ikenaka,Seiichi Nagano,Tsutomu Sasaki,Munehisa Shimamura,Yoshitaka Nagai,Keisuke Hagihara,Hideki Mochizuki,Neurotherapeutics,Springer Science and Business Media LLC,2020年10月20日,研究論文(学術雑誌)
  • Combined Analysis of Clinical Data on HGF Gene Therapy to Treat Critical Limb Ischemia in Japan,Ryuichi Morishita,Munehisa Shimamura,Yasushi Takeya,Hironori Nakagami,Mitsuaki Chujo,Tetsuya Ishihama,Ei Yamada,Hiromi Rakugi,Current Gene Therapy,Bentham Science Publishers Ltd.,Vol. 20,2020年05月16日,研究論文(学術雑誌)
  • [Current status and perspectives in the development of therapeutic agents targeting post-ischemic inflammation in the acute stage of stroke].,Munehisa Shimamura,Hironori Nakagami,Tsutomu Sasaki,Ryuichi Morishita,Hideki Mochizuki,Rinsho shinkeigaku = Clinical neurology,Vol. 60,No. 4,p. 253-259,2020年03月31日,研究論文(学術雑誌)
  • Development of an IL-17A DNA Vaccine to Treat Systemic Lupus Erythematosus in Mice.,Hiroshi Koriyama,Yuka Ikeda,Hironori Nakagami,Munehisa Shimamura,Shota Yoshida,Hiromi Rakugi,Ryuichi Morishita,Vaccines,Vol. 8,No. 1,2020年02月12日
  • AJP001, a novel helper T-cell epitope, induces a humoral immune response with activation of innate immunity when included in a peptide vaccine.,Akiko Tenma,Hironori Nakagami,Hideki Tomioka,Makoto Sakaguchi,Ryoko Ide,Hiroshi Koriyama,Hiroki Hayashi,Munehisa Shimamura,Hiromi Rakugi,Ryuichi Morishita,FASEB bioAdvances,Vol. 1,No. 12,p. 760-772,2019年12月
  • Preventative effects of the partial RANKL peptide MHP1-AcN in a mouse model of imiquimod-induced psoriasis.,Nan Ju,Munehisa Shimamura,Hiroki Hayashi,Yuka Ikeda,Shota Yoshida,Ayumi Nakamura,Ryuichi Morishita,Hiromi Rakugi,Hironori Nakagami,Scientific reports,Vol. 9,No. 1,p. 15434-15434,2019年10月28日
  • Novel Method for Rapid Assessment of Cognitive Impairment Using High-Performance Eye-Tracking Technology.,Akane Oyama,Shuko Takeda,Yuki Ito,Tsuneo Nakajima,Yoichi Takami,Yasushi Takeya,Koichi Yamamoto,Ken Sugimoto,Hideo Shimizu,Munehisa Shimamura,Taiichi Katayama,Hiromi Rakugi,Ryuichi Morishita,Scientific reports,Vol. 9,No. 1,p. 12932-12932,2019年09月10日,研究論文(学術雑誌)
  • A vaccine targeting blood clot formation: what is the potential?,Shimamura M,Nakagami H,Expert review of vaccines,Vol. 18,No. 5,p. 419-421,2019年05月
  • [Analysis of PEG-J associated complications in 14 adult patients treated with levodopa-carbidopa intestinal gel].,Munehisa Shimamura,Shinichiro Shinzaki,Kensuke Ikenaka,Kuni Konaka,Daisuke Hirozawa,Teruyuki Ishikura,Makoto Hideshima,Tomohito Nakano,Takaya Kitano,Tetsuo Takehara,Hideki Mochizuki,Rinsho shinkeigaku = Clinical neurology,Vol. 59,No. 3,p. 153-156,2019年03月28日,研究論文(学術雑誌)
  • β-arrestin-2 in PAR-1-biased signaling has a crucial role in endothelial function via PDGF-β in stroke.,Kanki H,Sasaki T,Matsumura S,Yokawa S,Yukami T,Shimamura M,Sakaguchi M,Furuno T,Suzuki T,Mochizuki H,Cell death & disease,Vol. 10,No. 2,p. 100-100,2019年02月,研究論文(学術雑誌)
  • Temporal and spatial profile of polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) in ischemic stroke in mice.,Tomohiro Kawano,Munehisa Shimamura,Hironori Nakagami,Hideaki Kanki,Tsutomu Sasaki,Hideki Mochizuki,PloS one,Vol. 14,No. 5,2019年,研究論文(学術雑誌)
  • Development of a novel RANKL-based peptide, microglial healing peptide1-AcN (MHP1-AcN), for treatment of ischemic stroke.,Shimamura M,Nakagami H,Shimizu H,Mukai H,Watanabe R,Okuzono T,Kawano T,Ikeda Y,Hayashi H,Yoshida S,Ju N,Mochizuki H,Morishita R,Scientific reports,Vol. 8,No. 1,2018年12月
  • Therapeutic Vaccine Against S100A9 (S100 Calcium-Binding Protein A9) Inhibits Thrombosis Without Increasing the Risk of Bleeding in Ischemic Stroke in Mice.,Kawano T,Shimamura M,Nakagami H,Iso T,Koriyama H,Takeda S,Baba K,Sasaki T,Sakaguchi M,Morishita R,Mochizuki H,Hypertension (Dallas, Tex. : 1979),Vol. 72,No. 6,p. 1355-1364,2018年12月,研究論文(学術雑誌)
  • [Levodopa-carbidopa intestinal gel treatment introduced by surgical gastrostomy in a patient of Parkinson's disease after Billroth II gastrojejunostomy].,Nakano T,Hirozawa D,Shimamura M,Sasaki T,Ikenaka K,Mochizuki H,Rinsho shinkeigaku = Clinical neurology,Vol. 58,No. 9,p. 570-573,2018年09月
  • Paraneoplastic Cerebellar Degeneration and Lambert-Eaton Myasthenic Syndrome Associated with Neuroendocrine Carcinoma of the Oropharynx.,Junji Takasugi,Munehisa Shimamura,Toru Koda,Toshihiro Kishikawa,Atsushi Hanamoto,Hidenori Inohara,Kazuaki Sato,Eiichi Morii,Masakatsu Motomura,Manabu Sakaguchi,Yuji Nakatsuji,Hideki Mochizuki,Internal medicine (Tokyo, Japan),Vol. 57,No. 4,p. 587-590,2018年02月15日,研究論文(学術雑誌)
  • Development of vaccine for dyslipidemia targeted to a proprotein convertase subtilisin/kexin type 9 (PCSK9) epitope in mice.,Ryo Kawakami,Yoichi Nozato,Hironori Nakagami,Yuka Ikeda,Munehisa Shimamura,Shota Yoshida,Jiao Sun,Tomohiro Kawano,Yoichi Takami,Takahisa Noma,Hiromi Rakugi,Tetsuo Minamino,Ryuichi Morishita,PloS one,Vol. 13,No. 2,2018年,研究論文(学術雑誌)
  • Therapeutic Effects of Systemic Administration of the Novel RANKL-Modified Peptide, MHP1, for Ischemic Stroke in Mice.,Shimamura M,Nakagami H,Shimizu H,Wakayama K,Kawano T,Ikeda Y,Hayashi H,Yoshida S,Mochizuki H,Morishita R,BioMed research international,Vol. 2018,2018年
  • イルベサルタンの食塩感受性高血圧モデルに対する改善効果,楠 博,谷山 義明,東 純哉,家串 和真,岩林 正明,志水 秀郎,尾崎 和成,牧野 寛史,島村 宗尚,大津 礼,楽木 宏実,森下 竜一,日本抗加齢医学会総会プログラム・抄録集,(一社)日本抗加齢医学会,Vol. 12回,p. 188-188,2012年06月
  • メタボリックシンドローム(MetS)病態モデルにおける肝細胞増殖因子(HGF),楠 博,谷山 義明,東 純哉,家串 和真,岩林 正明,志水 秀郎,尾崎 和成,大津 礼,牧野 寛史,島村 宗尚,楽木 宏実,森下 竜一,日本抗加齢医学会総会プログラム・抄録集,(一社)日本抗加齢医学会,Vol. 12回,p. 189-189,2012年06月
  • 拡張期心不全における新しい臨床評価 漢方スコアと心エコー指標との関係(New clinical evaluation in diastolic heart failure: The relation between Kampo-scores and indices with echocardiography),尾崎 和成,牧野 寛史,志水 秀郎,谷山 義明,島村 宗尚,楠 博,岩林 正明,大津 礼,岸田 友紀,萩原 圭祐,森下 竜一,日本抗加齢医学会総会プログラム・抄録集,(一社)日本抗加齢医学会,Vol. 12回,p. 191-191,2012年06月
  • HGF(肝細胞増殖因子)はメタボサルタンの腎保護作用のエフェクター分子である,楠 博,谷山 義明,岩林 正明,家串 和真,大津 礼,清水 秀郎,島村 宗尚,尾崎 和成,楽木 宏実,森下 竜一,日本抗加齢医学会総会プログラム・抄録集,(一社)日本抗加齢医学会,Vol. 11回,p. 259-259,2011年04月
  • Mutations of the Lipoprotein Receptor-Related Protein-6 Modulate Ischemic Brain Injury,Abe Takato,Zhou Ping,Shimamura Munehisa,Ross M. E,Iadecola Costantino,Stroke,Vol. 41,No. 4,2010年
  • A model of cerebrovascular injury in rats,Kouji Wakayama,Munehisa Shimamura,Masataka Sata,Nobutaka Koibuchi,Naoyuki Sato,Toshio Ogihara,Ryuichi Morishita,JOURNAL OF NEUROSCIENCE METHODS,ELSEVIER SCIENCE BV,Vol. 175,No. 2,p. 187-195,2008年11月,研究論文(学術雑誌)
  • Prevention of amyloid ss-induced memory impairment by fluvastatin, associated with the decrease in amyloid ss accumulation and oxidative stress in amyloid ss injection mouse model,Hitomi Kurinami,Naoyuki Sato,Mitsuru Shinohara,Daisuke Takeuchi,Shuko Takeda,Munehisa Shimamura,Toshio Ogihara,Ryuichi Morishita,INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE,SPANDIDOS PUBL LTD,Vol. 21,No. 5,p. 531-537,2008年05月,研究論文(学術雑誌)
  • A novel model of cerebrovascular injury in rats,Kouji Wakayama,Munehisa Shimamura,Masataka Sata,Naoyuki Sato,Nobutaka Koibuchi,Ryuichi Morishita,STROKE,LIPPINCOTT WILLIAMS & WILKINS,Vol. 39,No. 2,p. 717-717,2008年02月
  • Nuclear factor-kappa B activation and postischemic inflammation are suppressed in CD36-null mice after middle cerebral artery occlusion,Alexander Kunz,Takato Abe,Karin Hochrainer,Munehisa Shimamura,Josef Anrather,Gianfranco Racchumi,Ping Zhou,Costantino Iadecola,JOURNAL OF NEUROSCIENCE,SOC NEUROSCIENCE,Vol. 28,No. 7,p. 1649-1658,2008年02月,研究論文(学術雑誌)
  • NF-kappa B is a key mediator of cerebral aneurysm formation,Tomohiro Aoki,Hiroharu Kataoka,Munehisa Shimamura,Hironori Nakagami,Kouji Wakayama,Takuya Moriwaki,Ryota Ishibashi,Kazuhiko Nozaki,Ryuichi Morishita,Nobuo Hashimoto,CIRCULATION,LIPPINCOTT WILLIAMS & WILKINS,Vol. 116,No. 24,p. 2830-2840,2007年12月,研究論文(学術雑誌)
  • Quantitative measurement of neurological deficit after mild (30 min) transient middle cerebral artery occlusion in rats,Kouji Wakayama,Munehisa Shimamura,Masataka Sata,Naoyuki Sato,Koji Kawakami,Hirotsugu Fukuda,Takuji Tomimatsu,Toshio Ogihara,Ryuichi Morishita,BRAIN RESEARCH,ELSEVIER SCIENCE BV,Vol. 1130,No. 1,p. 181-187,2007年01月,研究論文(学術雑誌)
  • Transfer of HGF by microbubbleenhanced ultrasound improve amyloid beta-induced memory impairment in mice,Daisuke Takeuchi,Naoyuki Sato,Munehisa Shimamura,Hitomi Kurinami,Ryuichi Morishita,Toshio Ogihara,JOURNAL OF HYPERTENSION,LIPPINCOTT WILLIAMS & WILKINS,Vol. 24,p. 200-200,2006年12月
  • Statin therapy is effective in cognition impairment,Hitomi Kurinami,Naoyuki Sato,Daisuke Takeuchi,Munehisa Shimamura,Ryuichi Morishita,Toshio Ogihara,JOURNAL OF HYPERTENSION,LIPPINCOTT WILLIAMS & WILKINS,Vol. 24,p. 398-398,2006年12月
  • Effective assessment of behavioral function after subcortical infarct induced by transient middle cerebral artery occlusion in rats,Kouji Wakayama,Munehisa Shimamura,Masataka Sata,Koji Kawakami,Naoyuki Sato,Toshio Ogihara,Ryuichi Morishita,JOURNAL OF HYPERTENSION,LIPPINCOTT WILLIAMS & WILKINS,Vol. 24,p. 406-406,2006年12月
  • Post-ischemic administration of fluvastatin improves cognitive dysfunction in the chronic stage of cerebral infarction in rat model,Munehisa Shimamura,Naoyuki Sato,Maka Sata sata,Koji Kawakami,Takuya Hayashi,Hidehiro Iida,Toshio Ogihara,Ryuichi Morishita,JOURNAL OF HYPERTENSION,LIPPINCOTT WILLIAMS & WILKINS,Vol. 24,p. 406-407,2006年12月

MISC

  • 炎症制御をターゲットにした脳梗塞急性期治療薬開発の現状と展望,島村 宗尚,中神 啓徳,佐々木 勉,森下 竜一,望月 秀樹,臨床神経学,Vol. 60,p. 253-259,2020年,記事・総説・解説・論説等(学術雑誌)
  • 【多系統萎縮症-新たな展開】線条体黒質変性症,島村 宗尚,望月 秀樹,Clinical Neuroscience,(株)中外医学社,Vol. 37,No. 9,p. 1059-1060,2019年09月
  • レボドパ/カルビドパ配合経腸用液療法14例におけるPEG-J関連合併症の検討,島村 宗尚,新崎 信一郎,池中 建介,小仲 邦,廣澤 太輔,石倉 照之,秀嶋 信,中野 智仁,北野 貴也,竹原 徹郎,望月 秀樹,臨床神経学,(一社)日本神経学会,Vol. 59,No. 3,p. 153-156,2019年03月
  • 開腹胃瘻造設術により、レボドパ/カルビドパ配合経腸用液療法を導入したパーキンソン病の1例,中野 智仁,廣澤 太輔,島村 宗尚,佐々木 勉,池中 建介,望月 秀樹,臨床神経学,(一社)日本神経学会,Vol. 58,No. 9,p. 570-573,2018年09月
  • S100A9タンパク質を標的とした新規抗血栓ワクチンによる脳梗塞予防法の開発,河野友裕,河野友裕,島村宗尚,島村宗尚,中神啓徳,佐々木勉,森下竜一,望月秀樹,日本心血管内分泌代謝学会学術総会プログラム及び抄録集,(株)メディカルレビュー社,Vol. 21st,No. 2,p. 110-104,2017年12月
  • Glial fibrillary acidic protein (GFAP) is a novel biomarker for the prediction of autoimmune diabetes,Zhengda Pang,Akifumi Kushiyama,Jiao Sun,Takako Kikuchi,Hiroki Yamazaki,Yasuhiko Iwamoto,Hiroshi Koriyama,Shota Yoshida,Munehisa Shimamura,Masayoshi Higuchi,Tomohiro Kawano,Yoichi Takami,Hiromi Rakugi,Ryuichi Morishita,Hironori Nakagami,FASEB JOURNAL,FEDERATION AMER SOC EXP BIOL,Vol. 31,No. 9,p. 4053-4063,2017年09月
  • 【アンチエイジング研究-世界の趨勢と日本】各領域におけるアンチエイジング研究 脳・心血管系のアンチエイジング研究 認知症と脳血管老化,島村 宗尚,望月 秀樹,森下 竜一,医学のあゆみ,医歯薬出版(株),Vol. 261,No. 6,p. 601-605,2017年05月
  • Transplantation of lineage-negative stem cells in pterygopalatine artery ligation induced retinal ischemia–reperfusion injury in mice,Gillipsie Minhas,Sudesh Prabhakar,Ryuichi Morishita,Munehisa Shimamura,Reema Bansal,Akshay Anand,Molecular and Cellular Biochemistry,Vol. 429,No. 1-2,p. 123-136,2017年05月
  • Angiotensin II Peptide Vaccine Protects Ischemic Brain Through Reducing Oxidative Stress,Kouji Wakayama,Munehisa Shimamura,Jun-ichi Suzuki,Ryo Watanabe,Hiroshi Koriyama,Hiroshi Akazawa,Hironori Nakagami,Hideki Mochizuki,Mitsuaki Isobe,Ryuichi Morishita,STROKE,LIPPINCOTT WILLIAMS & WILKINS,Vol. 48,No. 5,p. 1362-+,2017年05月
  • A peptide vaccine targeting angiotensin II attenuates the cardiac dysfunction induced by myocardial infarction,Ryo Watanabe,Jun-ichi Suzuki,Kouji Wakayama,Yasuhiro Maejima,Munehisa Shimamura,Hiroshi Koriyama,Hironori Nakagami,Hidetoshi Kumagai,Yuichi Ikeda,Hiroshi Akazawa,Ryuichi Morishita,Issei Komuro,Mitsuaki Isobe,SCIENTIFIC REPORTS,NATURE PUBLISHING GROUP,Vol. 7,2017年03月
  • S100A9タンパク質を標的とした新規抗血栓ワクチンによる脳梗塞予防法の開発,河野友裕,島村宗尚,中神啓徳,郡山弘,佐々木勉,森下竜一,望月秀樹,Anti-Aging Science,Vol. 9,No. 2,2017年
  • Evaluating the potential of the GFAP-KLH immune-tolerizing vaccine for type 1 diabetes in mice,Zhengda Pang,Masayoshi Higuchi,Hiroshi Koriyama,Shota Yoshida,Hitomi Kurinami,Munehisa Shimamura,Yoichi Takami,Hiromi Rakugi,Ryuichi Morishita,Hironori Nakagami,FEBS LETTERS,WILEY-BLACKWELL,Vol. 591,No. 1,p. 129-136,2017年01月
  • A Novel Therapeutic Peptide as a Partial Agonist of RANKL in Ischemic Stroke,Hitomi Kurinami,Munehisa Shimamura,Hironori Nakagami,Hideo Shimizu,Hiroshi Koriyama,Tomohiro Kawano,Kouji Wakayama,Hideki Mochizuki,Hiromi Rakugi,Ryuichi Morishita,SCIENTIFIC REPORTS,NATURE PUBLISHING GROUP,Vol. 6,2016年11月
  • Current therapies and investigational drugs for peripheral arterial disease,Jun-ichi Suzuki,Munehisa Shimamura,Hiroyuki Suda,Kouji Wakayama,Hidetoshi Kumagai,Yuichi Ikeda,Hiroshi Akazawa,Mitsuaki Isobe,Issei Komuro,Ryuichi Morishita,HYPERTENSION RESEARCH,NATURE PUBLISHING GROUP,Vol. 39,No. 4,p. 183-191,2016年04月,書評論文,書評,文献紹介等
  • Therapeutic Application of an Angiotensin II Peptide Vaccine in a Middle Cerebral Artery Occlusion Model in Rats,Kouji Wakayama,Munehisa Shimamura,Jun-ichi Suzuki,Mitsuaki Isobe,Hironori Nakagami,Ryuichi Morishita,STROKE,LIPPINCOTT WILLIAMS & WILKINS,Vol. 47,2016年02月,研究発表ペーパー・要旨(国際会議)
  • Development of a Novel Anti-inflammatory and Anti-osteoplastic Peptide Based on De-loop and Ef-loop in Rankl for Treatment of Ischemic Stroke,Hitomi Kurinami,Munehisa Shimamura,Hironori Nakagami,Hideo Shimizu,Hiroshi Koriyama,Tomohiro Kawano,Hideki Mochizuki,Ryuichi Morishita,STROKE,LIPPINCOTT WILLIAMS & WILKINS,Vol. 47,2016年02月,研究発表ペーパー・要旨(国際会議)
  • 【血管病としての認知症〜予防はどこまで可能か?〜】脳血管のアンチエイジングと認知症予防,島村 宗尚,中神 啓徳,里 直行,望月 秀樹,森下 竜一,分子脳血管病,(株)先端医学社,Vol. 15,No. 1,p. 14-18,2016年01月
  • A model of stroke and vascular injury in the brain,Munehisa Shimamura,Hironori Nakagami,Masataka Sata,Hitomi Kurinami,Kouji Wakayama,Hideki Mochizuki,Ryuichi Morishita,Mouse Models of Vascular Diseases,Springer Japan,p. 263-274,2016年01月01日
  • 【老化を科学する】糖尿病・脂質異常症と認知症,島村 宗尚,里 直行,中神 啓徳,望月 秀樹,森下 竜一,最新精神医学,(株)世論時報社,Vol. 20,No. 6,p. 517-524,2015年11月
  • Long-Term Reduction of High Blood Pressure by Angiotensin II DNA Vaccine in Spontaneously Hypertensive Rats,Hiroshi Koriyama,Hironori Nakagami,Futoshi Nakagami,Mariana Kiomy Osako,Mariko Kyutoku,Munehisa Shimamura,Hitomi Kurinami,Tomohiro Katsuya,Hiromi Rakugi,Ryuichi Morishita,HYPERTENSION,LIPPINCOTT WILLIAMS & WILKINS,Vol. 66,No. 1,p. 167-174,2015年07月
  • 【内科医が知っておくべき認知症・せん妄・うつの特徴と鑑別】高血圧・糖尿病と認知症・うつ・せん妄,栗波 仁美,島村 宗尚,里 直行,森下 竜一,Mebio,(株)メジカルビュー社,Vol. 32,No. 6,p. 4-13,2015年06月
  • 【各国の治療ガイドラインからみたRAS抑制薬の位置づけ】高齢者(認知症を含む)におけるRAS抑制薬の位置づけ,島村 宗尚,里 直行,中神 啓徳,森下 竜一,Angiotensin Research,(株)先端医学社,Vol. 12,No. 1,p. 43-49,2015年01月
  • Modeling transient retinal ischemia in mouse by ligation of pterygopalatine artery,Gillipsie Minhas,Ryuichi Morishita,Munehisa Shimamura,Reema Bansal,Akshay Anand,Annals of Neurosciences,Indian Academy of Neurosciences,Vol. 22,No. 4,p. 222-225,2015年
  • Gene therapy for peripheral arterial disease,Munehisa Shimamura,Hironori Nakagami,Yoshiaki Taniyama,Ryuichi Morishita,EXPERT OPINION ON BIOLOGICAL THERAPY,INFORMA HEALTHCARE,Vol. 14,No. 8,p. 1175-1184,2014年08月,書評論文,書評,文献紹介等
  • 【最新臨床脳卒中学[上]-最新の診断と治療-】治療戦略を目指した研究 基礎研究 脳梗塞治療標的分子細胞外基質ペリオスチン,島村 宗尚,谷山 義明,中神 啓徳,森下 竜一,日本臨床,(株)日本臨床社,Vol. 72,No. 増刊5 最新臨床脳卒中学(上),p. 423-427,2014年07月
  • The dipeptidyl peptidase-4 inhibitor teneligliptin improved endothelial dysfunction and insulin resistance in the SHR/NDmcr-cp rat model of metabolic syndrome,Hironori Nakagami,Zhengda Pang,Takashi Shimosato,Toshinori Moritani,Hitomi Kurinami,Hiroshi Koriyama,Akiko Tenma,Munehisa Shimamura,Ryuichi Morishita,HYPERTENSION RESEARCH,NATURE PUBLISHING GROUP,Vol. 37,No. 7,p. 629-635,2014年07月
  • Long-term expression of periostin during the chronic stage of ischemic stroke in mice,Munehisa Shimamura,Yoshiaki Taniyama,Hironori Nakagami,Naruto Katsuragi,Kouji Wakayama,Hiroshi Koriyama,Hitomi Kurinami,Akiko Tenma,Hideki Tomioka,Ryuichi Morishita,HYPERTENSION RESEARCH,NATURE PUBLISHING GROUP,Vol. 37,No. 6,p. 494-499,2014年06月
  • Research for Localized High-Efficient Gene Transfer by the Magnetic Force Control Using High Temperature Superconducting Bulk Magnet,Junya Tamada,Yoshihiro Oaku,Fumihito Mishima,Yoko Akiyama,Mariana KiomyOsako,Munehisa Shimamura,Hironori Nakagami,Shigehiro Nishijima,IEEE TRANSACTIONS ON APPLIED SUPERCONDUCTIVITY,IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC,Vol. 24,No. 3,2014年06月
  • OPG/RANKL/RANK axis is a critical inflammatory signaling system in ischemic brain in mice,Munehisa Shimamura,Hironori Nakagami,Mariana K. Osako,Hitomi Kurinami,Hiroshi Koriyama,Pang Zhengda,Hideki Tomioka,Akiko Tenma,Kouji Wakayama,Ryuichi Morishita,PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,NATL ACAD SCIENCES,Vol. 111,No. 22,p. 8191-8196,2014年06月
  • Prohibitin Viral Gene Transfer Protects Hippocampal CA1 Neurons From Ischemia and Ameliorates Postischemic Hippocampal Dysfunction,Hitomi Kurinami,Munehisa Shimamura,Tao Ma,Liping Qian,Kenzo Koizumi,Laibaik Park,Eric Klann,Giovanni Manfredi,Costantino Iadecola,Ping Zhou,STROKE,LIPPINCOTT WILLIAMS & WILKINS,Vol. 45,No. 4,p. 1131-1138,2014年04月
  • Possible modification of Alzheimer's disease by statins in nnidlife: interactions with genetic and non-genetic risk factors,Mitsuru Shinohara,Naoyuki Sato,Munehisa Shimamura,Hitomi Kurinami,Toshimitsu Hamasaki,Amarnath Chatterjee,Hiromi Rakugi,Ryuichi Morishita,FRONTIERS IN AGING NEUROSCIENCE,FRONTIERS MEDIA SA,Vol. 6,2014年04月,書評論文,書評,文献紹介等
  • Therapeutic vaccine against DPP4 improves glucose metabolism in mice,Zhengda Pang,Hironori Nakagami,Mariana K. Osako,Hiroshi Koriyama,Futoshi Nakagami,Hideki Tomioka,Munehisa Shimamura,Hitomi Kurinami,Yoichi Takami,Ryuichi Morishita,Hiromi Rakugi,PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,NATL ACAD SCIENCES,Vol. 111,No. 13,p. E1256-E1263,2014年04月
  • Development of novel DNA vaccine for VEGF in murine cancer model,Mariko Kyutoku,Hironori Nakagami,Hiroshi Koriyama,Hideki Tomioka,Futoshi Nakagami,Munehisa Shimamura,Hitomi Kurinami,Pang Zhengda,Dong Hyun Jo,Jeong Hun Kim,Nobuyuki Takakura,Ryuichi Morishita,SCIENTIFIC REPORTS,NATURE PUBLISHING GROUP,Vol. 3,2013年11月
  • Unique remodeling processes after vascular injury in intracranial arteries: analysis using a novel mouse model,Munehisa Shimamura,Hironori Nakagami,Masataka Sata,Minoru Takaoka,Junya Azuma,Mariana Kiomy Osako,Hiroshi Koriyama,Hitomi Kurinami,Kouji Wakayama,Takashi Miyake,Ryuichi Morishita,JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM,NATURE PUBLISHING GROUP,Vol. 33,No. 8,p. 1153-1159,2013年08月
  • Prostaglandin E-2 type 1 receptors contribute to neuronal apoptosis after transient forebrain ischemia,Munehisa Shimamura,Ping Zhou,Barbara Casolla,Liping Qian,Carmen Capone,Hitomi Kurinami,Costantino Iadecola,Josef Anrather,JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM,NATURE PUBLISHING GROUP,Vol. 33,No. 8,p. 1207-1214,2013年08月
  • 脳血管性認知症 2.脳のアンチエイジング,島村宗尚,中神啓徳,里直行,森下竜一,Anti Aging Sci,Vol. 5,No. 2,p. 82-88,2013年06月25日
  • Do Angiotensin Receptor Blockers Protect Against Alzheimer's Disease?,Hitomi Kurinami,Munehisa Shimamura,Naoyuki Sato,Hironori Nakagami,Ryuichi Morishita,DRUGS & AGING,ADIS INT LTD,Vol. 30,No. 6,p. 367-372,2013年06月
  • Cross-Talk of Receptor Activator of Nuclear Factor-kappa B Ligand Signaling With Renin-Angiotensin System in Vascular Calcification,Mariana Kiomy Osako,Hironori Nakagami,Munehisa Shimamura,Hiroshi Koriyama,Futoshi Nakagami,Hideo Shimizu,Takashi Miyake,Masao Yoshizumi,Hiromi Rakugi,Ryuichi Morishita,ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY,LIPPINCOTT WILLIAMS & WILKINS,Vol. 33,No. 6,p. 1287-+,2013年06月
  • Inhibition of Neointima Formation through DNA Vaccination for Apolipoprotein(a): A New Therapeutic Strategy for Lipoprotein(a),Mariko Kyutoku,Hironori Nakagami,Hiroshi Koriyama,Futoshi Nakagami,Munehisa Shimamura,Hitomi Kurinami,Hideki Tomioka,Takashi Miyake,Tomohiro Katsuya,Ryuichi Morishita,SCIENTIFIC REPORTS,NATURE PUBLISHING GROUP,Vol. 3,2013年04月
  • Plasmid DNA-based gene therapy in neurological disorders,Munehisa Shimamura,Hironori Nakagami,Hitomi Kurinami,Naoyuki Sato,Ryuichi Morishita,Gene Therapy: Technologies and Applications,Future Medicine Ltd.,p. 47-56,2013年03月01日
  • Decrease in Blood Pressure and Regression of Cardiovascular Complications by Angiotensin II Vaccine in Mice,Futoshi Nakagami,Hiroshi Koriyama,Hironori Nakagami,Mariana Kiomy Osako,Munehisa Shimamura,Mariko Kyutoku,Takashi Miyake,Tomohiro Katsuya,Hiromi Rakugi,Ryuichi Morishita,PLOS ONE,PUBLIC LIBRARY SCIENCE,Vol. 8,No. 3,2013年03月
  • Chronic deposition of Aβ influences microcirculation in the chronic stage of cerebral Ischemia,Munehisa Shimamura,Naoyuki Sato,Hironori Nakagami,Mariana Kiomy Osako,Mariko Kyutoku,Kouji Wakayama,Ryuichi Morishita,Immunology, Endocrine and Metabolic Agents in Medicinal Chemistry,Vol. 13,No. 1,p. 77-80,2013年
  • Rosuvastatin ameliorates obesity and proteinuria in zucker diabetic fatty rats,Hironori Nakagami,Takashi Shimosato,Munehisa Shimamura,Ryuichi Morishita,Immunology, Endocrine and Metabolic Agents in Medicinal Chemistry,Vol. 13,No. 2,p. 144-149,2013年
  • Gene Therapy and Cell-Based Therapies for Therapeutic Angiogenesis in Peripheral Artery Disease,Munehisa Shimamura,Hironori Nakagami,Hiroshi Koriyama,Ryuichi Morishita,BIOMED RESEARCH INTERNATIONAL,HINDAWI PUBLISHING CORPORATION,Vol. 2013,2013年,書評論文,書評,文献紹介等
  • 内科疾患と脳神経疾患:診断と治療の進歩 V.生活習慣病と認知症,島村宗尚,里直行,森下竜一,日本内科学会雑誌,Vol. 101,No. 8,p. 2204-2211,2012年08月10日
  • Ultrasound microbubbles and needleless jet injector for gene transfer of naked plasmid dna,Munehisa Shimamura,Hironori Nakagami,Naoyuki Sato,Yoshiaki Taniyama,Yasuo Kunigiza,Ryuichi Morishita,Plasmids: Genetics, Applications and Health,p. 137-147,2012年08月01日
  • HIG1, a novel regulator of mitochondrial γ-secretase, maintains normal mitochondrial function,Hiroki Hayashi,Hironori Nakagami,Makiko Takeichi,Munehisa Shimamura,Nobutaka Koibuchi,Eiji Oiki,Naoyuki Sato,Hiroshi Koriyama,Masaki Mori,Rodriguez Gerardo Araujo,Akito Maeda,Ryuichi Morishita,Katsuto Tamai,Yasufumi Kaneda,FASEB Journal,Vol. 26,No. 6,p. 2306-2317,2012年06月
  • Role of Central Nervous System Periostin in Cerebral Ischemia,Munehisa Shimamura,Yoshiaki Taniyama,Naruto Katsuragi,Nobutaka Koibuchi,Mariko Kyutoku,Naoyuki Sato,Mohammad Allahtavakoli,Kouji Wakayama,Hironori Nakagami,Ryuichi Morishita,STROKE,LIPPINCOTT WILLIAMS & WILKINS,Vol. 43,No. 4,p. 1108-U341,2012年04月
  • 後天的危険因子に着目したアルツハイマー病の新規診断・治療法の開発,武田朱公,里直行,内尾(山田)こずえ,島村宗尚,湯久浩,守口篤,楽木宏実,森下竜一,精神薬療研究年報,No. 44,p. 85-86,2012年03月21日
  • Nifedipine prevents hepatic fibrosis in a non-alcoholic steatohepatitis model induced by an L-methionine-and choline-deficient diet,Hironori Nakagami,Munehisa Shimamura,Takashi Miyake,Takashi Shimosato,Noriko Minobe,Toshinori Moritani,Mariana Kiomy Osako,Futoshi Nakagami,Hiroshi Koriyama,Mariko Kyutoku,Hideo Shimizu,Tomohiro Katsuya,Ryuichi Morishita,MOLECULAR MEDICINE REPORTS,SPANDIDOS PUBL LTD,Vol. 5,No. 1,p. 37-40,2012年01月
  • Cilnidipine, but not amlodipine, ameliorates osteoporosis in ovariectomized hypertensive rats through inhibition of the N-type calcium channel,Hideo Shimizu,Hironori Nakagami,Natsuki Yasumasa,Osako Kiomy Mariana,Mariko Kyutoku,Hiroshi Koriyama,Futoshi Nakagami,Munehisa Shimamura,Hiromi Rakugi,Ryuichi Morishita,HYPERTENSION RESEARCH,NATURE PUBLISHING GROUP,Vol. 35,No. 1,p. 77-81,2012年01月
  • Pitavastatin improves endothelial function and glucose metabolism in ovariectomized mice,Hironori Nakagami,Mariana Kiomy Osako,Natsuki Yasumasa,Munehisa Shimamura,Mariko Kyutoku,Futoshi Nakagami,Hiroshi Koriyama,Hideki Tomioka,Tomohiro Katsuya,Ryuichi Morishita,Immunology, Endocrine and Metabolic Agents in Medicinal Chemistry,Bentham Science Publishers B.V.,Vol. 12,No. 1,p. 29-33,2012年
  • Lipoprotein(a) is a therapeutic target for cardiovascular disease,Mariko Kyutoku,Hironori Nakagami,Futoshi Nakagami,Hiroshi Koriyama,Mariana Kiomy Osako,Munehisa Shimamura,Takashi Miyake,Ryuichi Morishita,Immunology, Endocrine and Metabolic Agents in Medicinal Chemistry,Bentham Science Publishers B.V.,Vol. 12,No. 2,p. 118-121,2012年,書評論文,書評,文献紹介等
  • Screening of antihypertensive drugs for osteoclastic acid secretion and bone resorption by acridine orange,Hideo Shimizu,Hironori Nakagami,Natsuki Yasumasa,Osako Kiomy Mariana,Mariko Kyutoku,Hiroshi Koriyama,Futoshi Nakagami,Munehisa Shimamura,Hiromi Rakugi,Ryuichi Morishita,Immunology, Endocrine and Metabolic Agents in Medicinal Chemistry,Bentham Science Publishers B.V.,Vol. 12,No. 3,p. 161-167,2012年
  • [Internal medicine and neurological diseases: progress in diagnosis and treatment. Topics: V. Dementia and life-style related disease].,Munehisa Shimamura,Naoyuki Sato,Ryuichi Morishita,Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine,Vol. 101,p. 2204-2211,2012年01月01日
  • Development of nucleic acid drugs for neurological disorders,Munehisa Shimamura,Naoyuki Sato,Hironori Nakagami,Yoshiaki Taniyama,Ryuichi Morishita,Current Topics in Medicinal Chemistry,Vol. 12,No. 15,p. 1621-1629,2012年,書評論文,書評,文献紹介等
  • Links Between Hypertension and Osteoporosis: Benidipine Ameliorates Osteoporosis in Ovariectomized Hypertensive Rats Through Promotion of Osteoblast Proliferation and Inhibition of Osteoclast Differentiation,Hideo Shimizu,Hironori Nakagami,Natsuki Yasumasa,Osako Kiyomy Mariana,Mariko Kyutoku,Hiroshi Koriyama,Futoshi Nakagami,Munehisa Shimamura,Hiromi Rakugi,Ryuichi Morishita,Current Cardiovascular Risk Reports,Vol. 6,No. 4,p. 274-280,2012年,書評論文,書評,文献紹介等
  • Experimental and Clinical Application of Plasmid DNA in the Field of Central Nervous Diseases,Munehisa Shimamura,Naoyuki Sato,Ryuichi Morishita,CURRENT GENE THERAPY,BENTHAM SCIENCE PUBL LTD,Vol. 11,No. 6,p. 491-500,2011年12月,書評論文,書評,文献紹介等
  • Naked Plasmid DNA for Gene Therapy,Munehisa Shimamura,Ryuichi Morishita,CURRENT GENE THERAPY,BENTHAM SCIENCE PUBL LTD,Vol. 11,No. 6,p. 433-433,2011年12月
  • スタチンのベータ・アミロイドに対する特異的な作用―アルツハイマー病予防の可能性,里直行,篠原充,島村宗尚,楽木宏実,森下竜一,Anti Aging Sci,Vol. 3,2011年11月30日
  • Prevention of Neointimal Hyperplasia After Angioplasty Using NF-kappaB Decoy Oligodeoxynucleotides-Coated Balloon Catheter in Rabbit Restenosis Model,Takashi Miyake,Munehisa Shimamura,Hironori Nakagami,Ryuichi Morishita,CIRCULATION,LIPPINCOTT WILLIAMS & WILKINS,Vol. 124,No. 21,2011年11月,研究発表ペーパー・要旨(国際会議)
  • Irbesartan improves endothelial dysfunction, abnormal lipid profile, proteinuria and liver dysfunction in Zucker diabetic fatty rats independent of glucose and insulin levels,Munehisa Shimamura,Hironori Nakagami,Takashi Shimosato,Toshinori Moritani,Futoshi Nakagami,Mariana Kiomy Osako,Takashi Miyake,Hiroshi Koriyama,Hideo Shimizu,Ryuichi Morishita,EXPERIMENTAL AND THERAPEUTIC MEDICINE,SPANDIDOS PUBL LTD,Vol. 2,No. 5,p. 957-961,2011年09月
  • Key Role Of Periostin In Cerebral Ischemia,Munehisa Shimamura,Yoshiaki Taniyama,Hironori Nakagami,Naoyuki Sato,Nobutaka Koibuchi,Mohammad Allahtavakoli,Kouji Wakayama,Takashi Miyake,Hideo Shimizu,Ryuichi Morishita,STROKE,LIPPINCOTT WILLIAMS & WILKINS,Vol. 42,No. 3,p. E67-E67,2011年03月,研究発表ペーパー・要旨(国際会議)
  • Systemic Administration of Ribbon-type Decoy Oligodeoxynucleotide Against Nuclear Factor kappa B and Ets Prevents Abdominal Aortic Aneurysm in Rat Model,Takashi Miyake,Motokuni Aoki,Mariana K. Osako,Munehisa Shimamura,Hironori Nakagami,Ryuichi Morishita,MOLECULAR THERAPY,NATURE PUBLISHING GROUP,Vol. 19,No. 1,p. 181-187,2011年01月
  • A STATIN PROTECTS ABETA-INDUCED MEMORY IMPAIRMENT IN MICE,Hitomi Kurinami,Naoyuki Sato,Mitsuru Shinohara,Daisuke Takeuchi,Shuko Takeda,Munehisa Shimamura,Ryuichi Morishita,JOURNAL OF GENE MEDICINE,JOHN WILEY & SONS LTD,Vol. 12,No. 12,p. 1027-1028,2010年12月,研究発表ペーパー・要旨(国際会議)
  • ULTRASOUND-MEDIATED GENE TRANSFER OF HGF IMPROVED ABETA-INDUCED COGNITIVE IMPAIRMENT IN MICE ASSOCIATED WITH UPREGULATION OF BDNF, AND DOWNREGULATION OF OXIDATIVE STRESS.,Daisuke Takeuchi,Naoyuki Sato,Hitomi Kurinami,Munehisa Shimamura,Shuko Takeda,Mitsuru Shinohara,Ryuichi Morishita,JOURNAL OF GENE MEDICINE,JOHN WILEY & SONS LTD,Vol. 12,No. 12,p. 1048-1049,2010年12月,研究発表ペーパー・要旨(国際会議)
  • [Gene therapy for diabetic microangiopathy].,Munehisa Shimamura,Ryuichi Morishita,Nippon rinsho. Japanese journal of clinical medicine,Vol. 68 Suppl 9,p. 207-211,2010年11月01日
  • Prevention and regression of non-alcoholic steatohepatitis (NASH) in a rat model by metabosartan, telmisartan,Hironori Nakagami,Mariana Kiomy Osako,Futoshi Nakagami,Takashi Shimosato,Noriko Minobe,Toshinori Moritani,Munehisa Shimamura,Takashi Miyake,Hideo Shimizu,Yasushi Takeya,Ryuichi Morishita,INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE,SPANDIDOS PUBL LTD,Vol. 26,No. 4,p. 477-481,2010年10月
  • Estrogen Inhibits Vascular Calcification via Vascular RANKL System Common Mechanism of Osteoporosis and Vascular Calcification,Mariana Kiomy Osako,Hironori Nakagami,Nobutaka Koibuchi,Hideo Shimizu,Futoshi Nakagami,Hiroshi Koriyama,Munehisa Shimamura,Takashi Miyake,Hiromi Rakugi,Ryuichi Morishita,CIRCULATION RESEARCH,LIPPINCOTT WILLIAMS & WILKINS,Vol. 107,No. 4,p. 466-U57,2010年08月
  • Estrogen attenuates vascular remodeling in Lp(a) transgenic mice,Futoshi Nakagami,Hironori Nakagami,Mariana Kiomy Osako,Masaaki Iwabayashi,Yoshiaki Taniyama,Takefumi Doi,Hideo Shimizu,Munehisa Shimamura,Hiromi Rakugi,Ryuichi Morishita,ATHEROSCLEROSIS,ELSEVIER IRELAND LTD,Vol. 211,No. 1,p. 41-47,2010年07月
  • Reduction of brain β-amyloid (Aβ) by fluvastatin, a hydroxymethylglutaryl-CoA reductase inhibitor, through increase in degradation of amyloid precursor protein C-terminal fragments (APP-CTFs) and Aβ clearance,Mitsuru Shinohara,Naoyuki Sato,Hitomi Kurinami,Daisuke Takeuchi,Shuko Takeda,Munehisa Shimamura,Toshihide Yamashita,Yasuo Uchiyama,Hiromi Rakugi,Ryuichi Morishita,Journal of Biological Chemistry,Vol. 285,No. 29,p. 22091-22102,2010年07月
  • Key Role of CD36 in Toll-Like Receptor 2 Signaling in Cerebral Ischemia,Takato Abe,Munehisa Shimamura,Katherine Jackman,Hitomi Kurinami,Josef Anrather,Ping Zhou,Costantino Iadecola,STROKE,LIPPINCOTT WILLIAMS & WILKINS,Vol. 41,No. 5,p. 898-904,2010年05月
  • Combination of thiazide diuretics and angiotensin receptor blockers attenuates osteoporosis in hypertensive rats,Hideo Shimizu,Hironori Nakagami,Natsuki Yasumasa,Mariana Kiomy Osako,Munehisa Shimamura,Takeshi Miyake,Futoshi Nakagami,Hiroshi Koriyama,Hiromi Rakugi,Ryuichi Morishita,Immunology, Endocrine and Metabolic Agents in Medicinal Chemistry,Bentham Science Publishers B.V.,Vol. 10,No. 3,p. 115-122,2010年
  • Toll-like receptor 2/1 signaling in cerebral ischemia requires the scavenger receptor CD36,T. Abe,M. Shimamura,J. Anrather,P. Zhou,G. Racchumi,C. Iadecola,JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM,NATURE PUBLISHING GROUP,Vol. 29,p. S94-S95,2009年10月,研究発表ペーパー・要旨(国際会議)
  • The neuroprotective effect of prostaglandin E2 EP1 receptor inhibition has a wide therapeutic window, is sustained in time and is not sexually dimorphic,Takato Abe,Alexander Kunz,Munehisa Shimamura,Ping Zhou,Josef Anrather,Costantino Iadecola,JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM,NATURE PUBLISHING GROUP,Vol. 29,No. 1,p. 66-72,2009年01月
  • Injection of HGF plasmid cDNA to prevent manifestation of Parkinson disease: A preclinical study using a primate model,Hiromi Koike,Akihiko Ishida,Takuya Hayashi,Munehisa Shimamura,Shinya Mizuno,Toshikazu Nakamura,Hidehiro Iida,Toshio Ogihara,Yasufumi Kaneda,Ryuichi Morishita,Open Gene Therapy Journal,Vol. 2,p. 38-44,2009年
  • Prevention of amyloid β-induced memory impairment by fluvastatin, associated with the decrease in amyloid β accumulation and oxidative stress in amyloid β injection mouse model,Hitomi Kurinami,Naoyuki Sato,Mitsuru Shinohara,Daisuke Takeuchi,Shuko Takeda,Munehisa Shimamura,Toshio Ogihara,Ryuichi Morishita,International Journal of Molecular Medicine,Vol. 21,No. 5,p. 531-537,2008年05月
  • Alleviation of Aβ-induced cognitive impairment by ultrasound-mediated gene transfer of HGF in a mouse model,D. Takeuchi,N. Sato,M. Shimamura,H. Kurinami,S. Takeda,M. Shinohara,S. Suzuki,M. Kojima,T. Ogihara,R. Morishita,Gene Therapy,Vol. 15,No. 8,p. 561-571,2008年04月
  • Prevention of amyloid beta-induced memory impairment by fluvastatin, associated with the decrease in amyloid beta accumulation and oxidative stress in amyloid beta injection mouse model,H. Kurinami,N. Sato,M. Shinohara,D. Takeuchi,S. Takeda,M. Shimamura,T. Ogihara,R. Morishita,ANNALS OF NUTRITION AND METABOLISM,KARGER,Vol. 53,No. 1,p. 59-59,2008年,研究発表ペーパー・要旨(国際会議)
  • Delayed postischemic treatment with fluvastatin improved cognitive impairment after stroke in rats,Munehisa Shimamura,Naoyuki Sato,Masataka Sata,Hitomi Kurinami,Daisuke Takeuchi,Kouji Wakayama,Takuya Hayashi,Hidehiro Iida,Ryuichi Morishita,STROKE,LIPPINCOTT WILLIAMS & WILKINS,Vol. 38,No. 12,p. 3251-3258,2007年12月
  • Expression of hepatocyte growth factor and c-Met after spinal cord injury in rats,Munehisa Shimamura,Naoyuki Sato,Masataka Sata,Kouji Wakayama,Toshio Ogihara,Ryuichi Morishita,BRAIN RESEARCH,ELSEVIER SCIENCE BV,Vol. 1151,p. 188-194,2007年06月
  • Prevention of onset of Parkinson's disease by in vivo gene transfer of human hepatocyte growth factor in rodent model: a model of gene therapy for Parkinson's disease,H. Koike,A. Ishida,M. Shimamura,S. Mizuno,T. Nakamura,T. Ogihara,Y. Kaneda,R. Morishita,GENE THERAPY,NATURE PUBLISHING GROUP,Vol. 13,No. 23,p. 1639-1644,2006年12月
  • Development of new screening system for Alzheimer disease, in vitro Aβ sink assay, to identify the dissociation of soluble Aβ from fibrils,Naoyuki Sato,Masayasu Okochi,Yoshiaki Taniyama,Hitomi Kurinami,Munehisa Shimamura,Daisuke Takeuchi,Hizuki Hamada,Akio Fukumori,Kazuyuki Kiyosue,Takahisa Taguchi,Toshiyuki Tanaka,Masayuki Miyasaka,Masatoshi Takeda,Toshio Ogihara,Ryuichi Morishita,Neurobiology of Disease,Vol. 22,No. 3,p. 487-495,2006年06月
  • Gene transfer of hepatocyte growth factor gene improves learning and memory in the chronic stage of cerebral infarction,M Shimamura,N Sato,S Waguri,Y Uchiyama,T Hayashi,H Iida,T Nakamura,T Ogihara,Y Kaneda,R Morishita,HYPERTENSION,LIPPINCOTT WILLIAMS & WILKINS,Vol. 47,No. 4,p. 742-751,2006年04月
  • HVJ-based non-viral gene transfer method: Successful gene therapy using HGF and VEGF genes in experimental ischemia,Munehisa Shimamura,Naoyuki Sato,Shinichi Yoshimura,Yasufumi Kaneda,Ryuichi Morishita,Frontiers in Bioscience,Vol. 11,No. 1,p. 753-759,2006年,書評論文,書評,文献紹介等
  • Gene transfer into adult rat spinal cord using naked plasmid DNA and ultrasound microbubbles,M Shimamura,N Sato,Y Taniyama,H Kurinami,H Tanaka,T Takami,T Ogihara,M Tohyama,Y Kaneda,R Morishita,JOURNAL OF GENE MEDICINE,JOHN WILEY & SONS LTD,Vol. 7,No. 11,p. 1468-1474,2005年11月
  • Gene transfer of HGF gene improves learning and memory in the chronic stage of cerebral infarction,M Shimamura,N Sato,M Aoki,S Waguri,T Hayashi,T Ogihara,Y Kaneda,R Morishita,CIRCULATION,LIPPINCOTT WILLIAMS & WILKINS,Vol. 112,No. 17,p. U336-U337,2005年10月,研究発表ペーパー・要旨(国際会議)
  • Recent progress in cerebrovascular gene therapy,N Sato,M Shimamura,R Morishita,CURRENT NEUROVASCULAR RESEARCH,BENTHAM SCIENCE PUBL LTD,Vol. 2,No. 3,p. 235-247,2005年07月,書評論文,書評,文献紹介等
  • Recovery of cognitive function with gene therapy using helpatocyte growth factor gene after ischemic stroke,M Shimamura,N Sato,M Aoki,S Waguri,T Hayashi,H Iida,Y Uchiyama,T Nakamura,T Ogihara,Y Kaneda,R Morishita,STROKE,LIPPINCOTT WILLIAMS & WILKINS,Vol. 36,No. 2,p. 513-513,2005年02月,研究発表ペーパー・要旨(国際会議)
  • Development of efficient plasmid DNA transfer into adult rat central nervous system using microbubble-enhanced ultrasound,M Shimamura,N Sato,Y Taniyama,S Yamamoto,M Endoh,H Kurinami,M Aoki,T Ogihara,Y Kaneda,R Morishita,GENE THERAPY,NATURE PUBLISHING GROUP,Vol. 11,No. 20,p. 1532-1539,2004年10月
  • A novel therapeutic strategy to treat brain ischemia: Over-expression of hepatocyte growth factor gene reduced ischemic injury without cerebral edema in rat model,M Shimamura,N Sato,T Ogihara,Y Kaneda,R Morishita,MOLECULAR THERAPY,ACADEMIC PRESS INC ELSEVIER SCIENCE,Vol. 9,p. S88-S88,2004年05月,研究発表ペーパー・要旨(国際会議)
  • Prevention of onset of Parkinson's disease by in vivo gene transfer of human hepatocyte growth factor in primate model: A model of gene therapy for Parkinson's disease,H Koike,A Ishida,M Shimamura,N Sato,N Tomita,Y Kaneda,R Morishita,MOLECULAR THERAPY,ACADEMIC PRESS INC ELSEVIER SCIENCE,Vol. 9,p. S196-S196,2004年05月,研究発表ペーパー・要旨(国際会議)
  • A novel therapeutic strategy to treat brain ischemia: Overexpression of hepatocyte growth factor gene reduced ischemic injury without brain edema in rat model,M Shimamura,N Sato,M Aoki,Y Kaneda,T Ogihara,R Morishita,JOURNAL OF HYPERTENSION,LIPPINCOTT WILLIAMS & WILKINS,Vol. 22,p. S84-S85,2004年02月,研究発表ペーパー・要旨(国際会議)
  • A novel therapeutic strategy to treat brain ischemia: over-expression of hepatocyte growth factor gene reduced ischemic injury without brain edema in rat model.,M Shimamura,N Sato,M Aoki,S Waguri,Y Uchiyama,T Ogihara,Y Kaneda,R Morishita,STROKE,LIPPINCOTT WILLIAMS & WILKINS,Vol. 35,No. 1,p. 282-282,2004年01月,研究発表ペーパー・要旨(国際会議)
  • Intrathecal injection of HVJ-E containing HGF gene to cerebrospinal fluid can prevent and ameliorate hearing impairment in rats,K Oshima,M Shimamura,S Mizuno,K Tamai,K Doi,R Morishita,T Nakamura,T Kubo,Y Kaneda,FASEB JOURNAL,FEDERATION AMER SOC EXP BIOL,Vol. 18,No. 1,p. 212-214,2004年01月
  • Novel therapeutic strategy to treat brain ischemia - Overexpression of hepatocyte growth factor gene reduced ischemic injury without cerebral edema in rat model,M Shimamura,N Sato,K Oshima,M Aoki,H Kurinami,S Waguri,Y Uchiyama,T Ogihara,Y Kaneda,R Morishita,CIRCULATION,LIPPINCOTT WILLIAMS & WILKINS,Vol. 109,No. 3,p. 424-431,2004年01月
  • Modification of plasmid DNA-based gene transfer into central nerve system,Y Taniyama,M Shimamura,N Sato,N Tomita,M Endho,J Azuma,K Iekushi,Y Kaneda,T Ogihara,R Monshita,STATE OF THE ART: ULTRASONICS IN MEDICINE,ELSEVIER SCIENCE BV,Vol. 1274,p. 159-163,2004年
  • ラット中大脳動脈閉塞モデルにおける肝細胞増殖因子(HGF)遺伝子による遺伝子治療の検討,島村 宗尚,里 直行,青木 元邦,和栗 聡,内山 安男,金田 安史,荻原 俊男,森下 竜一,日本高血圧学会総会プログラム・抄録集,(NPO)日本高血圧学会,Vol. 26回,p. 187-187,2003年10月
  • 血管新生作用を促進する肝細胞増殖因子(HGF)による脳梗塞の遺伝子治療,島村宗尚,里直行,青木元邦,森下竜一,Bio Ind,Vol. 20,No. 9,p. 5-10,2003年09月12日
  • Hepatocyte growth factor gene transfer in cerebrospinal fluid can prevent and ameliorate hearing impairment in rats,K Oshima,M Shimamura,K Tamai,R Morishita,Y Kaneda,MOLECULAR THERAPY,ACADEMIC PRESS INC ELSEVIER SCIENCE,Vol. 7,No. 5,p. S251-S251,2003年05月,研究発表ペーパー・要旨(国際会議)
  • Gene therapy for neurological diseases,Munehisa Shimamura,Motokuni Aoki,Ryuichi Morishita,Japanese Journal of Neurosurgery,Japanese Congress of Neurological Surgeons,Vol. 12,No. 3,p. 147-155,2003年03月01日
  • A unique case of sporadic Creutzfeldt-Jacob disease presenting as progressive supranuclear palsy,M Shimamura,E Uyama,T Hirano,T Murakami,S Mita,T Kitamoto,M Uchino,INTERNAL MEDICINE,JAPAN SOC INTERNAL MEDICINE,Vol. 42,No. 2,p. 195-198,2003年02月
  • HVJ-envelope vector for gene transfer into central nervous system,M Shimamura,R Morishita,M Endoh,K Oshima,M Aoki,S Waguri,Y Uchiyama,Y Kaneda,BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,ACADEMIC PRESS INC ELSEVIER SCIENCE,Vol. 300,No. 2,p. 464-471,2003年01月
  • Gene therapy for preventing delayed neuronal death using hepatocyte growth factor,M Shimamura,R Morishita,S Yoshimura,K Hayashi,M Aoki,Y Kaneda,T Ogihara,JOURNAL OF HYPERTENSION,LIPPINCOTT WILLIAMS & WILKINS,Vol. 20,p. S179-S179,2002年06月,研究発表ペーパー・要旨(国際会議)
  • Therapeutic angiogenesis using gene therapy,Munehisa Shimamura,Motokuni Aoki,Ryuichi Morishita,Respiration and Circulation,Vol. 50,p. 341-347,2002年04月01日
  • Gene therapy for cerebral ischemic disease using hepatocyte growth factor (HGF): In vivo gene transfer of HGF to subarachnoid space accelerates angiogenesis and prevents delayed neuronal death,M Shimamura,SI Yoshimura,K Hayashi,R Morishita,CIRCULATION,LIPPINCOTT WILLIAMS & WILKINS,Vol. 104,No. 17,p. 530-530,2001年10月,研究発表ペーパー・要旨(国際会議)
  • Autosomal dominant proximal spinal muscular atrophy of adult-onset,E Uyama,K Yamaguchi,M Shimamura,S Imamura,M Uchino,NEUROMUSCULAR DISORDERS,PERGAMON-ELSEVIER SCIENCE LTD,Vol. 11,No. 6-7,p. 649-649,2001年09月,研究発表ペーパー・要旨(国際会議)
  • A novel CLCN1 mutation: P480T in a Japanese family with Thomsen's myotonia congenita,R Sasaki,N Ito,M Shimamura,T Murakami,S Kuzuhara,M Uchino,E Uyama,MUSCLE & NERVE,JOHN WILEY & SONS INC,Vol. 24,No. 3,p. 357-363,2001年03月
  • Hodgkin's disease preceded by unique neurological symptoms,Munehisa Shimamura,Yuji Uchida,Tadashi Terasaki,Yoichiro Hashimoto,Hiroshi Yamasaki,Hiroyuki Tsuda,Tadashi Wakayama,Tetsuo Ando,Makoto Uchino,Internal Medicine,Japanese Society of Internal Medicine,Vol. 40,No. 8,p. 819-821,2001年
  • Treatment for recurrent paradoxical brain embolism through the patent foramen ovale,Munehisa Shimamura,Yoichiro Hashimoto,Satoshi Orita,Tadashi Terasaki,Makoto Uchino,Brain and Nerve,Vol. 53,No. 4,p. 357-361,2001年
  • A transesophageal echocariographic study for the detection of patent foramen ovale in patients with paradoxical brain embolism - Importance of repeat examination-,M Shimamura,S Orita,T Terasaki,Y Hashimoto,T Hirano,M Uchino,STROKE,LIPPINCOTT WILLIAMS & WILKINS,Vol. 31,No. 11,p. 2779-2779,2000年11月,研究発表ペーパー・要旨(国際会議)
  • Cerebral embolism in systemic lupus erythematosus with Libman-Sacks endocarditis: A case report,J. Kasuya,Y. Hashimoto,T. Terasaki,M. Shimamura,M. Uchino,Clinical Neurology,Vol. 40,No. 7,p. 707-711,2000年