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Shimamura Munehisa
島村　宗尚
Shimamura Munehisa
島村　宗尚
Institutional repository
Graduate School of Medicine，Endowed Chair Professor
Institutional repository

Research History 12

  1. 2023/01 - Present
    大阪大学大学院医学系研究科遺伝子幹細胞再生治療学　寄附講座教授

  2. 2015/04 - Present
    Osaka University　Graduate School of Medicine

  3. 2014/07 - Present
    Osaka University　Graduate School of Medicine

  4. 2010/04 - 2015/03
    大阪大学大学院連合小児発達学研究科　健康発達医学講座　寄附講座准教授

  5. 2009/05 - 2010/03
    Osaka University　Graduate School of Medicine

  6. 2007/04 - 2009/05
    コーネル大学医学部　神経生物学　リサーチフェロー

  7. 2005/04 - 2007/03
    The University of Tokyo　Graduate School of Medicine

  8. 2000/04 - 2001/03
    Kumamoto University　University Hospital

  9. 1999/04 - 2000/03
    熊本市立市民病院　神経内科　医員

  10. 1998/04 - 1999/03
    Kumamoto University　University Hospital

  11. 1997/10 - 1998/03
    済生会熊本病院循環器内科　研修医

  12. 1997/04 - 1997/09
    Kumamoto University　University Hospital

Education 4

  1. 国立循環器病センター　放射線医学部 任意研修生

    2003/06 - 2005/03

  2. 大阪大学大学院　医学系研究科遺伝子治療学（大学院生）

    2001/04 - 2005/03

  3. Kumamoto University　School of Medicine

    1991/04 - 1997/03

  4. 熊本県立熊本高等学校

    - 1991/03

Research Areas 1

  1. Life sciences / Neurology /

Awards 2

  1. 日本抗加齢医学会学会賞

    2023/06

  2. 第22回日本抗加齢医学会総会優秀演題賞

    島村宗尚　2022

Papers 59

  1. R-spondin 3/LGR4 (Leucine-Rich Repeat-Containing G Protein-Coupled Receptor 4) Axis Is a Novel Inflammatory and Neurite Outgrowth Signaling System in the Ischemic Brain in Mice.

    Munehisa Shimamura, Hiroki Hayashi, Nan Ju, Shota Yoshida, Satoshi Baba, Tsutomu Sasaki, Hideki Mochizuki, Ryuichi Morishita, Hironori Nakagami

    Stroke　Vol. 54　No. 6　p. 1606-1615　2023/06　Research paper (scientific journal)

  2. Role of Polymorphonuclear Myeloid-Derived Suppressor Cells and Neutrophils in Ischemic Stroke.

    Haomin Yan, Tomohiro Kawano, Hideaki Kanki, Kumiko Nishiyama, Munehisa Shimamura, Hideki Mochizuki, Tsutomu Sasaki

    Journal of the American Heart Association　Vol. 12　No. 6　2023/03/21　Research paper (scientific journal)

  3. Prevention of bleomycin-induced pulmonary fibrosis by a RANKL peptide in mice

    Nan Ju, Hiroki Hayashi, Munehisa Shimamura, Satoshi Baba, Shota Yoshida, Ryuichi Morishita, Hiromi Rakugi, Hironori Nakagami

    Scientific Reports　Vol. 12　No. 1　2022/12　Research paper (scientific journal)

    Publisher: Springer Science and Business Media LLC

  4. RANKL Impairs the TLR4 Pathway by Increasing TRAF6 and RANK Interaction in Macrophages.

    Ryerson Fonseca Mota, Paulo Henrique Cavalcanti de Araújo, Maria Eduarda Ramos Cezine, Flávia Sayuri Matsuo, Rodrigo Jair Morandi Metzner, Carlos Alberto Oliveira de Biagi Junior, Kamila Chagas Peronni, Hiroki Hayashi, Munehisa Shimamura, Hironori Nakagami, Mariana Kiomy Osako

    BioMed research international　Vol. 2022　p. 7740079-7740079　2022　Research paper (scientific journal)

  5. Prevention of vascular dementia via immunotherapeutic blockade of renin-angiotensin system in a rat model.

    Kouji Wakayama, Munehisa Shimamura, Shota Yoshida, Hiroki Hayashi, Nan Ju, Hironori Nakagami, Ryuichi Morishita

    Brain research　Vol. 1772　p. 147667-147667　2021/12/01　Research paper (scientific journal)

  6. Development of anti-thrombotic vaccine against human S100A9 in rhesus monkey

    Munehisa Shimamura, Koichi Kaikita, Hironori Nakagami, Tomohiro Kawano, Nan Ju, Hiroki Hayashi, Ryo Nakamaru, Shota Yoshida, Tsutomu Sasaki, Hideki Mochizuki, Kenichi Tsujita, Ryuichi Morishita

    Scientific Reports　Vol. 11　No. 1　2021/12　Research paper (scientific journal)

    Publisher: Springer Science and Business Media LLC

  7. Prevention of Acute Lung Injury by a Novel CD14-Inhibitory Receptor Activator of the NF-κB Ligand Peptide in Mice

    Nan Ju, Hiroki Hayashi, Munehisa Shimamura, Shota Yoshida, Ryo Nakamaru, Hironori Nakagami, Ryuichi Morishita, Hiromi Rakugi

    ImmunoHorizons　Vol. 5　No. 6　p. 438-447　2021/06/15　Research paper (scientific journal)

    Publisher: The American Association of Immunologists

  8. Preventative effects of the partial RANKL peptide MHP1-AcN in a mouse model of imiquimod-induced psoriasis.

    Nan Ju, Munehisa Shimamura, Hiroki Hayashi, Yuka Ikeda, Shota Yoshida, Ayumi Nakamura, Ryuichi Morishita, Hiromi Rakugi, Hironori Nakagami

    Scientific reports　Vol. 9　No. 1　p. 15434-15434　2019/10/28　Research paper (scientific journal)

  9. A vaccine targeting blood clot formation: what is the potential?

    Shimamura M, Nakagami H

    Expert review of vaccines　Vol. 18　No. 5　p. 419-421　2019/05

  10. Temporal and spatial profile of polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) in ischemic stroke in mice.

    Tomohiro Kawano, Munehisa Shimamura, Hironori Nakagami, Hideaki Kanki, Tsutomu Sasaki, Hideki Mochizuki

    PloS one　Vol. 14　No. 5　2019　Research paper (scientific journal)

  11. Development of a novel RANKL-based peptide, microglial healing peptide1-AcN (MHP1-AcN), for treatment of ischemic stroke.

    Shimamura M, Nakagami H, Shimizu H, Mukai H, Watanabe R, Okuzono T, Kawano T, Ikeda Y, Hayashi H, Yoshida S, Ju N, Mochizuki H, Morishita R

    Scientific reports　Vol. 8　No. 1　2018/12　Research paper (scientific journal)

    Publisher: Springer Science and Business Media LLC

  12. Therapeutic Vaccine Against S100A9 (S100 Calcium-Binding Protein A9) Inhibits Thrombosis Without Increasing the Risk of Bleeding in Ischemic Stroke in Mice.

    Kawano T, Shimamura M, Nakagami H, Iso T, Koriyama H, Takeda S, Baba K, Sasaki T, Sakaguchi M, Morishita R, Mochizuki H

    Hypertension (Dallas, Tex. : 1979)　Vol. 72　No. 6　p. 1355-1364　2018/12　Research paper (scientific journal)

  13. Therapeutic Effects of Systemic Administration of the Novel RANKL-Modified Peptide, MHP1, for Ischemic Stroke in Mice.

    Shimamura M, Nakagami H, Shimizu H, Wakayama K, Kawano T, Ikeda Y, Hayashi H, Yoshida S, Mochizuki H, Morishita R

    BioMed research international　Vol. 2018　p. 4637084-4637084　2018　Research paper (scientific journal)

  14. Nuclear factor-kappa B activation and postischemic inflammation are suppressed in CD36-null mice after middle cerebral artery occlusion

    Alexander Kunz, Takato Abe, Karin Hochrainer, Munehisa Shimamura, Josef Anrather, Gianfranco Racchumi, Ping Zhou, Costantino Iadecola

    JOURNAL OF NEUROSCIENCE　Vol. 28　No. 7　p. 1649-1658　2008/02　Research paper (scientific journal)

  15. Post-ischemic administration of fluvastatin improves cognitive dysfunction in the chronic stage of cerebral infarction in rat model

    Munehisa Shimamura, Naoyuki Sato, Maka Sata sata, Koji Kawakami, Takuya Hayashi, Hidehiro Iida, Toshio Ogihara, Ryuichi Morishita

    JOURNAL OF HYPERTENSION　Vol. 24　p. 406-407　2006/12

  16. A Vaccine Against Fibroblast Activation Protein Improves Murine Cardiac Fibrosis by Preventing the Accumulation of Myofibroblasts

    Shota Yoshida, Hiroki Hayashi, Takuro Kawahara, Shunsuke Katsuki, Mitsukuni Kimura, Rissei Hino, Jiao Sun, Ryo Nakamaru, Akiko Tenma, Masayoshi Toyoura, Satoshi Baba, Munehisa Shimamura, Tomohiro Katsuya, Ryuichi Morishita, Hiromi Rakugi, Tetsuya Matoba, Hironori Nakagami

    Circulation Research　2024/12/04　Research paper (scientific journal)

    Publisher: Ovid Technologies (Wolters Kluwer Health)

  17. Intradermal administration of DNA vaccine targeting Omicron SARS-CoV-2 via pyro-drive jet injector provides the prolonged neutralizing antibody production via germinal center reaction

    Hiroki Hayashi, Jiao Sun, Yuka Yanagida, Takako Otera, Jiayu A. Tai, Tomoyuki Nishikawa, Kunihiko Yamashita, Naoki Sakaguchi, Shota Yoshida, Satoshi Baba, Chin Yang Chang, Munehisa Shimamura, Sachiko Okamoto, Yasunori Amaishi, Hideto Chono, Junichi Mineno, Hiromi Rakugi, Ryuichi Morishita, Hironori Nakagami

    Scientific Reports　Vol. 13　No. 1　2023/08/10　Research paper (scientific journal)

    Publisher: Springer Science and Business Media LLC

  18. Impact of insufficient recovery of cerebral blood flow due to partial reperfusion on the pathophysiology of ischemic stroke in mice

    Munehisa Shimamura, Chin yang Chang, Hiroki Hayashi, Satoshi Baba, Shota Yoshida, Hironori Nakagami

    Neuroscience Letters　Vol. 810　p. 137370-137370　2023/07　Research paper (scientific journal)

    Publisher: Elsevier BV

  19. Antiepileptic drugs modulate Alzheimer-related tau aggregation in a neuronal activity-independent manner

    Yuki Ito, Shuko Takeda, Sayaka Moroi, Tsuneo Nakajima, Akane Oyama, Kunihiro Miki, Nanami Sugihara, Yoichi Takami, Yasushi Takeya, Munehisa Shimamura, Hiromi Rakugi, Ryuichi Morishita

    Dementia and Geriatric Cognitive Disorders　2023/03/06　Research paper (scientific journal)

    Publisher: S. Karger AG

  20. Peptide-based vaccine targeting IL17A attenuates experimental spondyloarthritis in HLA-B27 transgenic rats

    Hiroki Hayashi, Jiao Sun, Yuka Yanagida, Shota Yoshida, Satoshi Baba, Akiko Tenma, Masayoshi Toyoura, Sotaro Kawabata, Takako Ehara, Ryoko Asaki, Makoto Sakaguchi, Hideki Tomioka, Munehisa Shimamura, Ryuichi Morishita, Hiromi Rakugi, Tetsuya Tomita, Hironori Nakagami

    RMD Open　Vol. 9　No. 1　p. e002851-e002851　2023/02　Research paper (scientific journal)

    Publisher: BMJ

  21. High-Fat Diet-Induced Diabetic Conditions Exacerbate Cognitive Impairment in a Mouse Model of Alzheimer’s Disease Via a Specific Tau Phosphorylation Pattern

    Y. Ito, S. Takeda, T. Nakajima, A. Oyama, H. Takeshita, K. Miki, Y. Takami, Y. Takeya, M. Shimamura, H. Rakugi, R. Morishita

    The Journal Of Prevention of Alzheimer's Disease　2023　Research paper (scientific journal)

    Publisher: SERDI

  22. Modified DNA vaccine confers improved humoral immune response and effective virus protection against SARS-CoV-2 delta variant

    Hiroki Hayashi, Jiao Sun, Yuka Yanagida, Takako Otera, Miwa Sasai, Chin Yang Chang, Jiayu A. Tai, Tomoyuki Nishikawa, Kunihiko Yamashita, Naoki Sakaguchi, Shota Yoshida, Satoshi Baba, Munehisa Shimamura, Sachiko Okamoto, Yasunori Amaishi, Hideto Chono, Junichi Mineno, Hiromi Rakugi, Ryuichi Morishita, Masahiro Yamamoto, Hironori Nakagami

    Scientific Reports　Vol. 12　No. 1　2022/12/03　Research paper (scientific journal)

    Publisher: Springer Science and Business Media LLC

  23. A novel chronic dural port platform for continuous collection of cerebrospinal fluid and intrathecal drug delivery in free-moving mice

    Tsuneo Nakajima, Shuko Takeda, Yuki Ito, Akane Oyama, Yoichi Takami, Yasushi Takeya, Koichi Yamamoto, Ken Sugimoto, Hideo Shimizu, Munehisa Shimamura, Hiromi Rakugi, Ryuichi Morishita

    Fluids and Barriers of the CNS　Vol. 19　No. 1　2022/12　Research paper (scientific journal)

    Publisher: Springer Science and Business Media LLC

  24. 脳梗塞急性期治療のパラダイムシフト 炎症制御をターゲットにした急性期脳梗塞の創薬研究

    島村 宗尚, 中神 啓徳, 佐々木 勉, 望月 秀樹

    神経治療学　Vol. 39　No. 4　p. 517-521　2022/07

    Publisher: (一社)日本神経治療学会

  25. Preclinical study of a DNA vaccine targeting SARS-CoV-2.

    Hiroki Hayashi, Jiao Sun, Yuka Yanagida, Takako Otera, Ritsuko Kubota-Koketsu, Tatsuo Shioda, Chikako Ono, Yoshiharu Matsuura, Hisashi Arase, Shota Yoshida, Ryo Nakamaru, Nan Ju, Ryoko Ide, Akiko Tenma, Sotaro Kawabata, Takako Ehara, Makoto Sakaguchi, Hideki Tomioka, Munehisa Shimamura, Sachiko Okamoto, Yasunori Amaishi, Hideto Chono, Junichi Mineno, Takao Komatsuno, Yoshimi Saito, Hiromi Rakugi, Ryuichi Morishita, Hironori Nakagami

    Current research in translational medicine　Vol. 70　No. 4　p. 103348-103348　2022/04/20　Research paper (scientific journal)

  26. Therapeutic vaccine for chronic diseases after the COVID-19 Era.

    Hironori Nakagami, Hiroki Hayashi, Munehisa Shimamura, Hiromi Rakugi, Ryuichi Morishita

    Hypertension research : official journal of the Japanese Society of Hypertension　Vol. 44　No. 9　p. 1047-1053　2021/09　Research paper (scientific journal)

  27. High neutrophil/lymphocyte ratio at cancer diagnosis predicts incidence of stroke in cancer patients

    Tomohiro Kawano, Tsutomu Sasaki, Yasufumi Gon, Takaya Kitano, Hideaki Kanki, Kenichi Todo, Munehisa Shimamura, Yasushi Matsumura, Ao Huang, Satoshi Hattori, Hideki Mochizuki

    Brain Communications　Vol. 3　No. 2　2021/04/05　Research paper (scientific journal)

    Publisher: Oxford University Press (OUP)

  28. A novel angiotensin II peptide vaccine without an adjuvant in mice.

    Ryo Nakamaru, Hironori Nakagami, Hiroki Hayashi, Jiao Sun, Akiko Tenma, Koichi Yamamoto, Munehisa Shimamura, Ryuichi Morishita, Hiromi Rakugi

    Journal of hypertension　Vol. 39　No. 1　p. 181-189　2021/01　Research paper (scientific journal)

  29. The CD153 vaccine is a senotherapeutic option for preventing the accumulation of senescent T cells in mice

    Shota Yoshida, Hironori Nakagami, Hiroki Hayashi, Yuka Ikeda, Jiao Sun, Akiko Tenma, Hideki Tomioka, Tomohiro Kawano, Munehisa Shimamura, Ryuichi Morishita, Hiromi Rakugi

    Nature Communications　Vol. 11　No. 1　p. 2482-2482　2020/12　Research paper (scientific journal)

    Publisher: Springer Science and Business Media LLC

  30. [A case of Alexander disease presented with dystonia of lower limb and decreased dopaminergic uptake in dopamine transporter scintigraphy].

    Eri Hayano, Mikito Shimizu, Kousuke Baba, Munehisa Shimamura, Tomokatsu Yoshida, Hideki Mochizuki

    Rinsho shinkeigaku = Clinical neurology　Vol. 60　No. 10　p. 712-715　2020/10/24　Research paper (scientific journal)

  31. Go-sha-jinki-Gan Alleviates Inflammation in Neurological Disorders via p38-TNF Signaling in the Central Nervous System

    Shiying Jiang, Kousuke Baba, Tatsusada Okuno, Makoto Kinoshita, Chi-Jing Choong, Hideki Hayakawa, Hiroshi Sakiyama, Kensuke Ikenaka, Seiichi Nagano, Tsutomu Sasaki, Munehisa Shimamura, Yoshitaka Nagai, Keisuke Hagihara, Hideki Mochizuki

    Neurotherapeutics　2020/10/20　Research paper (scientific journal)

    Publisher: Springer Science and Business Media LLC

  32. Progress of Gene Therapy in Cardiovascular Disease.

    Munehisa Shimamura, Hironori Nakagami, Fumihiro Sanada, Ryuichi Morishita

    Hypertension (Dallas, Tex. : 1979)　Vol. 76　No. 4　p. 1038-1044　2020/10　Research paper (scientific journal)

  33. Combined Analysis of Clinical Data on HGF Gene Therapy to Treat Critical Limb Ischemia in Japan

    Ryuichi Morishita, Munehisa Shimamura, Yasushi Takeya, Hironori Nakagami, Mitsuaki Chujo, Tetsuya Ishihama, Ei Yamada, Hiromi Rakugi

    Current Gene Therapy　Vol. 20　No. 1　p. 25-35　2020/05/16　Research paper (scientific journal)

  34. [Current status and perspectives in the development of therapeutic agents targeting post-ischemic inflammation in the acute stage of stroke].

    Munehisa Shimamura, Hironori Nakagami, Tsutomu Sasaki, Ryuichi Morishita, Hideki Mochizuki

    Rinsho shinkeigaku = Clinical neurology　Vol. 60　No. 4　p. 253-259　2020/03/31　Research paper (scientific journal)

  35. Development of an IL-17A DNA Vaccine to Treat Systemic Lupus Erythematosus in Mice.

    Hiroshi Koriyama, Yuka Ikeda, Hironori Nakagami, Munehisa Shimamura, Shota Yoshida, Hiromi Rakugi, Ryuichi Morishita

    Vaccines　Vol. 8　No. 1　2020/02/12　Research paper (scientific journal)

  36. A vaccine for ischemic stroke

    Munehisa Shimamura, Tomohiro Kawano, Kouji Wakayama, Hironori Nakagami

    Therapeutic Vaccines as Novel Immunotherapy: Biological and Clinical Concepts　p. 21-32　2020/01/01　Part of collection (book)

    Publisher: Springer Singapore

  37. AJP001, a novel helper T-cell epitope, induces a humoral immune response with activation of innate immunity when included in a peptide vaccine.

    Akiko Tenma, Hironori Nakagami, Hideki Tomioka, Makoto Sakaguchi, Ryoko Ide, Hiroshi Koriyama, Hiroki Hayashi, Munehisa Shimamura, Hiromi Rakugi, Ryuichi Morishita

    FASEB bioAdvances　Vol. 1　No. 12　p. 760-772　2019/12　Research paper (scientific journal)

  38. レボドパ/カルビドパ配合経腸用液療法14例維持期におけるPEG-J関連合併症の検討

    島村 宗尚, 新崎 信一郎, 池中 健介, 小仲 邦, 竹原 徹郎, 望月 秀樹

    臨床神経学　Vol. 59　No. Suppl.　p. S219-S219　2019/11

    Publisher: (一社)日本神経学会

  39. Novel Method for Rapid Assessment of Cognitive Impairment Using High-Performance Eye-Tracking Technology.

    Akane Oyama, Shuko Takeda, Yuki Ito, Tsuneo Nakajima, Yoichi Takami, Yasushi Takeya, Koichi Yamamoto, Ken Sugimoto, Hideo Shimizu, Munehisa Shimamura, Taiichi Katayama, Hiromi Rakugi, Ryuichi Morishita

    Scientific reports　Vol. 9　No. 1　p. 12932-12932　2019/09/10　Research paper (scientific journal)

  40. [Analysis of PEG-J associated complications in 14 adult patients treated with levodopa-carbidopa intestinal gel].

    Munehisa Shimamura, Shinichiro Shinzaki, Kensuke Ikenaka, Kuni Konaka, Daisuke Hirozawa, Teruyuki Ishikura, Makoto Hideshima, Tomohito Nakano, Takaya Kitano, Tetsuo Takehara, Hideki Mochizuki

    Rinsho shinkeigaku = Clinical neurology　Vol. 59　No. 3　p. 153-156　2019/03/28　Research paper (scientific journal)

  41. β-arrestin-2 in PAR-1-biased signaling has a crucial role in endothelial function via PDGF-β in stroke.

    Kanki H, Sasaki T, Matsumura S, Yokawa S, Yukami T, Shimamura M, Sakaguchi M, Furuno T, Suzuki T, Mochizuki H

    Cell death & disease　Vol. 10　No. 2　p. 100-100　2019/02　Research paper (scientific journal)

  42. [Levodopa-carbidopa intestinal gel treatment introduced by surgical gastrostomy in a patient of Parkinson's disease after Billroth II gastrojejunostomy].

    Nakano T, Hirozawa D, Shimamura M, Sasaki T, Ikenaka K, Mochizuki H

    Rinsho shinkeigaku = Clinical neurology　Vol. 58　No. 9　p. 570-573　2018/09

  43. Paraneoplastic Cerebellar Degeneration and Lambert-Eaton Myasthenic Syndrome Associated with Neuroendocrine Carcinoma of the Oropharynx.

    Junji Takasugi, Munehisa Shimamura, Toru Koda, Toshihiro Kishikawa, Atsushi Hanamoto, Hidenori Inohara, Kazuaki Sato, Eiichi Morii, Masakatsu Motomura, Manabu Sakaguchi, Yuji Nakatsuji, Hideki Mochizuki

    Internal medicine (Tokyo, Japan)　Vol. 57　No. 4　p. 587-590　2018/02/15　Research paper (scientific journal)

  44. Development of vaccine for dyslipidemia targeted to a proprotein convertase subtilisin/kexin type 9 (PCSK9) epitope in mice.

    Ryo Kawakami, Yoichi Nozato, Hironori Nakagami, Yuka Ikeda, Munehisa Shimamura, Shota Yoshida, Jiao Sun, Tomohiro Kawano, Yoichi Takami, Takahisa Noma, Hiromi Rakugi, Tetsuo Minamino, Ryuichi Morishita

    PloS one　Vol. 13　No. 2　2018　Research paper (scientific journal)

  45. 収縮期心不全に関する新しい臨床評価法 漢方のスコアと心エコー造影指標の関係性(New clinical evaluation in systolic heart failure: The relation between Kampo-scores and indices with echocardiography)

    尾崎 和成, 牧野 寛史, 志水 秀郎, 谷山 義明, 島村 宗尚, 楠 博, 清水 一賢, 大津 礼, 岸田 友紀, 萩原 圭祐, 森下 竜一

    日本抗加齢医学会総会プログラム・抄録集　Vol. 13回　p. 189-189　2013/06

    Publisher: (一社)日本抗加齢医学会

  46. 拡張期心不全における新しい臨床評価 漢方スコアと心エコー指標との関係(New clinical evaluation in diastolic heart failure: The relation between Kampo-scores and indices with echocardiography)

    尾崎 和成, 牧野 寛史, 志水 秀郎, 谷山 義明, 島村 宗尚, 楠 博, 岩林 正明, 大津 礼, 岸田 友紀, 萩原 圭祐, 森下 竜一

    日本抗加齢医学会総会プログラム・抄録集　Vol. 12回　p. 191-191　2012/06

    Publisher: (一社)日本抗加齢医学会

  47. 低用量の利尿剤とARB併用によるRAS活性の抑制と骨代謝改善効果

    志水 秀郎, 安政 奈都記, 島村 宗尚, 楠 博, 中神 啓徳, 森下 竜一

    日本抗加齢医学会総会プログラム・抄録集　Vol. 11回　p. 317-317　2011/04

    Publisher: (一社)日本抗加齢医学会

  48. 【アンチエイジングをめぐる最近の話題(PART 2)】アルツハイマー病と後天的危険因子

    里 直行, 武田 朱公, 篠原 充, 栗波 仁美, 林 真一郎, 島村 宗尚, 森下 竜一

    Anti-aging Science　Vol. 2　No. 1　p. 82-88　2010/02

    Publisher: (株)メディカルレビュー社

  49. Mutations of the Lipoprotein Receptor-Related Protein-6 Modulate Ischemic Brain Injury

    Abe Takato, Zhou Ping, Shimamura Munehisa, Ross M. E, Iadecola Costantino

    Stroke　Vol. 41　No. 4　2010

  50. A model of cerebrovascular injury in rats

    Kouji Wakayama, Munehisa Shimamura, Masataka Sata, Nobutaka Koibuchi, Naoyuki Sato, Toshio Ogihara, Ryuichi Morishita

    JOURNAL OF NEUROSCIENCE METHODS　Vol. 175　No. 2　p. 187-195　2008/11　Research paper (scientific journal)

  51. Prevention of amyloid ss-induced memory impairment by fluvastatin, associated with the decrease in amyloid ss accumulation and oxidative stress in amyloid ss injection mouse model

    Hitomi Kurinami, Naoyuki Sato, Mitsuru Shinohara, Daisuke Takeuchi, Shuko Takeda, Munehisa Shimamura, Toshio Ogihara, Ryuichi Morishita

    INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE　Vol. 21　No. 5　p. 531-537　2008/05　Research paper (scientific journal)

  52. A novel model of cerebrovascular injury in rats

    Kouji Wakayama, Munehisa Shimamura, Masataka Sata, Naoyuki Sato, Nobutaka Koibuchi, Ryuichi Morishita

    STROKE　Vol. 39　No. 2　p. 717-717　2008/02

  53. NF-kappa B is a key mediator of cerebral aneurysm formation

    Tomohiro Aoki, Hiroharu Kataoka, Munehisa Shimamura, Hironori Nakagami, Kouji Wakayama, Takuya Moriwaki, Ryota Ishibashi, Kazuhiko Nozaki, Ryuichi Morishita, Nobuo Hashimoto

    CIRCULATION　Vol. 116　No. 24　p. 2830-2840　2007/12　Research paper (scientific journal)

  54. Quantitative measurement of neurological deficit after mild (30 min) transient middle cerebral artery occlusion in rats

    Kouji Wakayama, Munehisa Shimamura, Masataka Sata, Naoyuki Sato, Koji Kawakami, Hirotsugu Fukuda, Takuji Tomimatsu, Toshio Ogihara, Ryuichi Morishita

    BRAIN RESEARCH　Vol. 1130　No. 1　p. 181-187　2007/01　Research paper (scientific journal)

  55. Transfer of HGF by microbubbleenhanced ultrasound improve amyloid beta-induced memory impairment in mice

    Daisuke Takeuchi, Naoyuki Sato, Munehisa Shimamura, Hitomi Kurinami, Ryuichi Morishita, Toshio Ogihara

    JOURNAL OF HYPERTENSION　Vol. 24　p. 200-200　2006/12

  56. Statin therapy is effective in cognition impairment

    Hitomi Kurinami, Naoyuki Sato, Daisuke Takeuchi, Munehisa Shimamura, Ryuichi Morishita, Toshio Ogihara

    JOURNAL OF HYPERTENSION　Vol. 24　p. 398-398　2006/12

  57. Effective assessment of behavioral function after subcortical infarct induced by transient middle cerebral artery occlusion in rats

    Kouji Wakayama, Munehisa Shimamura, Masataka Sata, Koji Kawakami, Naoyuki Sato, Toshio Ogihara, Ryuichi Morishita

    JOURNAL OF HYPERTENSION　Vol. 24　p. 406-406　2006/12

  58. 【βアミロイドの重合状態と神経細胞機能】βアミロイド可溶性オリゴマーと線維形成

    里 直行, 栗波 仁美, 島村 宗尚, 濱田 日月, 竹内 大亮, 長谷川 みゆき, 林 真一郎, 谷山 義明, 荻原 俊男, 森下 竜一

    Cognition and Dementia　Vol. 3　No. 4　p. 345-351　2004/10

    Publisher: (株)メディカルレビュー社

  59. 専門医に求められる最新の知識 Neuroscience 脳虚血性疾患に対する血管新生療法の試み

    林 真一郎, 島村 宗尚, 荻原 俊男, 森下 竜一

    脳神経外科速報　Vol. 13　No. 10　p. 1080-1084　2003/10

    Publisher: (株)メディカ出版

Misc. 142

  1. Angiotensin II Peptide Vaccine Protects Ischemic Brain Through Reducing Oxidative Stress

    Kouji Wakayama, Munehisa Shimamura, Jun-ichi Suzuki, Ryo Watanabe, Hiroshi Koriyama, Hiroshi Akazawa, Hironori Nakagami, Hideki Mochizuki, Mitsuaki Isobe, Ryuichi Morishita

    STROKE　Vol. 48　No. 5　p. 1362-+　2017/05

  2. A Novel Therapeutic Peptide as a Partial Agonist of RANKL in Ischemic Stroke

    Hitomi Kurinami, Munehisa Shimamura, Hironori Nakagami, Hideo Shimizu, Hiroshi Koriyama, Tomohiro Kawano, Kouji Wakayama, Hideki Mochizuki, Hiromi Rakugi, Ryuichi Morishita

    SCIENTIFIC REPORTS　Vol. 6　2016/11

  3. Long-term expression of periostin during the chronic stage of ischemic stroke in mice

    Munehisa Shimamura, Yoshiaki Taniyama, Hironori Nakagami, Naruto Katsuragi, Kouji Wakayama, Hiroshi Koriyama, Hitomi Kurinami, Akiko Tenma, Hideki Tomioka, Ryuichi Morishita

    HYPERTENSION RESEARCH　Vol. 37　No. 6　p. 494-499　2014/06

  4. OPG/RANKL/RANK axis is a critical inflammatory signaling system in ischemic brain in mice

    Munehisa Shimamura, Hironori Nakagami, Mariana K. Osako, Hitomi Kurinami, Hiroshi Koriyama, Pang Zhengda, Hideki Tomioka, Akiko Tenma, Kouji Wakayama, Ryuichi Morishita

    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　Vol. 111　No. 22　p. 8191-8196　2014/06

  5. Prohibitin Viral Gene Transfer Protects Hippocampal CA1 Neurons From Ischemia and Ameliorates Postischemic Hippocampal Dysfunction

    Hitomi Kurinami, Munehisa Shimamura, Tao Ma, Liping Qian, Kenzo Koizumi, Laibaik Park, Eric Klann, Giovanni Manfredi, Costantino Iadecola, Ping Zhou

    STROKE　Vol. 45　No. 4　p. 1131-1138　2014/04

  6. Unique remodeling processes after vascular injury in intracranial arteries: analysis using a novel mouse model

    Munehisa Shimamura, Hironori Nakagami, Masataka Sata, Minoru Takaoka, Junya Azuma, Mariana Kiomy Osako, Hiroshi Koriyama, Hitomi Kurinami, Kouji Wakayama, Takashi Miyake, Ryuichi Morishita

    JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM　Vol. 33　No. 8　p. 1153-1159　2013/08

  7. Prostaglandin E-2 type 1 receptors contribute to neuronal apoptosis after transient forebrain ischemia

    Munehisa Shimamura, Ping Zhou, Barbara Casolla, Liping Qian, Carmen Capone, Hitomi Kurinami, Costantino Iadecola, Josef Anrather

    JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM　Vol. 33　No. 8　p. 1207-1214　2013/08

  8. Role of Central Nervous System Periostin in Cerebral Ischemia

    Munehisa Shimamura, Yoshiaki Taniyama, Naruto Katsuragi, Nobutaka Koibuchi, Mariko Kyutoku, Naoyuki Sato, Mohammad Allahtavakoli, Kouji Wakayama, Hironori Nakagami, Ryuichi Morishita

    STROKE　Vol. 43　No. 4　p. 1108-U341　2012/04

  9. Key Role of CD36 in Toll-Like Receptor 2 Signaling in Cerebral Ischemia

    Takato Abe, Munehisa Shimamura, Katherine Jackman, Hitomi Kurinami, Josef Anrather, Ping Zhou, Costantino Iadecola

    STROKE　Vol. 41　No. 5　p. 898-904　2010/05

  10. Delayed postischemic treatment with fluvastatin improved cognitive impairment after stroke in rats

    Munehisa Shimamura, Naoyuki Sato, Masataka Sata, Hitomi Kurinami, Daisuke Takeuchi, Kouji Wakayama, Takuya Hayashi, Hidehiro Iida, Ryuichi Morishita

    STROKE　Vol. 38　No. 12　p. 3251-3258　2007/12

  11. Gene transfer of hepatocyte growth factor gene improves learning and memory in the chronic stage of cerebral infarction

    M Shimamura, N Sato, S Waguri, Y Uchiyama, T Hayashi, H Iida, T Nakamura, T Ogihara, Y Kaneda, R Morishita

    HYPERTENSION　Vol. 47　No. 4　p. 742-751　2006/04

  12. Novel therapeutic strategy to treat brain ischemia - Overexpression of hepatocyte growth factor gene reduced ischemic injury without cerebral edema in rat model

    M Shimamura, N Sato, K Oshima, M Aoki, H Kurinami, S Waguri, Y Uchiyama, T Ogihara, Y Kaneda, R Morishita

    CIRCULATION　Vol. 109　No. 3　p. 424-431　2004/01

  13. 定量的リン酸化プロテオミクスを用いたアルツハイマー病と糖尿病の病態連関の解析

    伊藤祐規, 武田朱公, 中嶋恒男, 大山茜, 三木国煕, 鷹見洋一, 竹屋泰, 島村宗尚, 山本浩一, 森下竜一

    日本老年医学会雑誌(Web)　Vol. 61　2024

  14. バイオインフォマティクス解析を用いたアルツハイマー病と糖尿病の病態連関の基盤にある細胞内シグナル伝達経路の探索

    伊藤祐規, 伊藤祐規, 武田朱公, 武田朱公, 中嶋恒男, 大山茜, 三木国熙, 鷹見洋一, 竹屋泰, 島村宗尚, 山本浩一, 森下竜一

    日本抗加齢医学会総会プログラム・抄録集　Vol. 24th　2024

  15. リン酸化プロテオーム解析を用いた糖尿病とアルツハイマー病を繋ぐ鍵分子の探索

    伊藤祐規, 伊藤祐規, 武田朱公, 武田朱公, 中嶋恒男, 大山茜, 三木国煕, 鷹見洋一, 竹屋泰, 島村宗尚, 樂木宏実, 森下竜一

    Dementia Japan　Vol. 37　No. 4　2023

  16. アイトラッキング式認知機能評価法を利用した通所介護での介入プログラムの有効性検証

    武田朱公, 武田朱公, 島村宗尚, 中嶋恒男, 伊藤祐規, 伊藤祐規, 井口健, 森下竜一

    Dementia Japan　Vol. 37　No. 4　2023

  17. Diabetes mellitus aggravates behavioral deficit and increases a site-specific phosphorylation of tau protein in Alzheimer’s disease mouse model.

    伊藤祐規, 伊藤祐規, 武田朱公, 武田朱公, 中嶋恒男, 大山茜, 竹下ひかり, 三木国煕, 鷹見洋一, 竹屋泰, 島村宗尚, 樂木宏実, 森下竜一

    日本高血圧学会総会プログラム・抄録集(CD-ROM)　Vol. 45th　2023

  18. Development of anti-thrombotic and hypertensive vaccine for prevention of ischemic stroke

    島村宗尚, 中神啓徳

    日本血栓止血学会誌　Vol. 32　No. 3　2021

  19. 部分再開通における脳梗塞の病態解析

    島村宗尚, 中神啓徳, 森下竜一

    日本抗加齢医学会総会プログラム・抄録集　Vol. 21st　2021

  20. 新型コロナウイルスをターゲットとしたDNAワクチンの開発

    林宏樹, 孫嬌, 柳田結花, 大寺量子, 塩田達夫, 小野慎子, 松浦善治, 蝶野英人, 峰野純一, 島村宗尚, 森下竜一, 楽木宏美, 中神啓徳

    日本ワクチン学会学術集会プログラム・抄録集　Vol. 25th　2021

  21. The Efficacy of Angiotensin II Peptide Vaccination Against White Matter Lesions of Vascular Dementia in Rats

    Kouji Wakayama, Munehisa Shimamura, Hironori Nakagami, Ryuichi Morishita

    STROKE　Vol. 51　2020/02　Research paper, summary (international conference)

  22. RANKL部分ペプチドMHP1による乾癬に対する治療効果についての検討

    島村宗尚, 島村宗尚, 鞠楠, 林宏樹, 中神啓徳, 森下竜一

    日本抗加齢医学会総会プログラム・抄録集　Vol. 20th　2020

  23. 炎症制御をターゲットにした脳梗塞急性期治療薬開発の現状と展望

    島村 宗尚, 中神 啓徳, 佐々木 勉, 森下 竜一, 望月 秀樹

    臨床神経学　Vol. 60　p. 253-259　2020　Article, review, commentary, editorial, etc. (scientific journal)

  24. 【多系統萎縮症-新たな展開】線条体黒質変性症

    島村 宗尚, 望月 秀樹

    Clinical Neuroscience　Vol. 37　No. 9　p. 1059-1060　2019/09

    Publisher: (株)中外医学社

  25. レボドパ/カルビドパ配合経腸用液療法14例におけるPEG-J関連合併症の検討

    島村 宗尚, 新崎 信一郎, 池中 建介, 小仲 邦, 廣澤 太輔, 石倉 照之, 秀嶋 信, 中野 智仁, 北野 貴也, 竹原 徹郎, 望月 秀樹

    臨床神経学　Vol. 59　No. 3　p. 153-156　2019/03

    Publisher: (一社)日本神経学会

  26. Analysis of PEG-J associated complications in 14 adult patients treated with levodopa-carbidopa intestinal gel

    島村宗尚, 新崎信一郎, 池中建介, 小仲邦, 廣澤太輔, 石倉照之, 秀嶋信, 中野智仁, 北野貴也, 竹原徹郎, 望月秀樹

    臨床神経学(Web)　Vol. 59　No. 3　2019

  27. 当院におけるレボドパ/カルビドパ配合経腸用液療法維持期PEG-J関連合併症の検討

    島村宗尚, 島村宗尚, 新崎信一郎, 池中健介, 小仲邦, 竹原徹郎, 望月秀樹

    パーキンソン病・運動障害疾患コングレスプログラム・抄録集　Vol. 13th　2019

  28. S100A9を標的とした抗血小板機能ワクチンの開発

    中神啓徳, 林宏樹, 河野友裕, 河野友裕, 島村宗尚, 島村宗尚

    日本NO学会学術集会プログラム抄録集　Vol. 19th　2019

  29. アンギオテンシンIIワクチンによる血管性認知症の治療効果検討

    島村宗尚, 島村宗尚, 若山幸示, 中神啓徳, 森下竜一

    Anti-Aging Science　Vol. 11　No. 1　2019

  30. 開腹胃瘻造設術により、レボドパ/カルビドパ配合経腸用液療法を導入したパーキンソン病の1例

    中野 智仁, 廣澤 太輔, 島村 宗尚, 佐々木 勉, 池中 建介, 望月 秀樹

    臨床神経学　Vol. 58　No. 9　p. 570-573　2018/09

    Publisher: (一社)日本神経学会

  31. 開腹胃瘻造設術により、レボドパ/カルビドパ配合経腸用液療法を導入したパーキンソン病の1例

    中野 智仁, 廣澤 太輔, 島村 宗尚, 佐々木 勉, 池中 建介, 望月 秀樹

    臨床神経学　Vol. 58　No. 9　p. 570-573　2018/09

    Publisher: (一社)日本神経学会

  32. S100A9タンパク質を標的とした新規抗血栓ワクチンによる脳梗塞予防法の開発

    河野友裕, 河野友裕, 島村宗尚, 島村宗尚, 中神啓徳, 佐々木勉, 森下竜一, 望月秀樹

    日本心血管内分泌代謝学会学術総会プログラム及び抄録集　Vol. 21st　No. 2　p. 110-104　2017/12

    Publisher: (株)メディカルレビュー社

  33. Glial fibrillary acidic protein (GFAP) is a novel biomarker for the prediction of autoimmune diabetes

    Zhengda Pang, Akifumi Kushiyama, Jiao Sun, Takako Kikuchi, Hiroki Yamazaki, Yasuhiko Iwamoto, Hiroshi Koriyama, Shota Yoshida, Munehisa Shimamura, Masayoshi Higuchi, Tomohiro Kawano, Yoichi Takami, Hiromi Rakugi, Ryuichi Morishita, Hironori Nakagami

    FASEB JOURNAL　Vol. 31　No. 9　p. 4053-4063　2017/09

  34. 【アンチエイジング研究-世界の趨勢と日本】各領域におけるアンチエイジング研究 脳・心血管系のアンチエイジング研究 認知症と脳血管老化

    島村 宗尚, 望月 秀樹, 森下 竜一

    医学のあゆみ　Vol. 261　No. 6　p. 601-605　2017/05

    Publisher: 医歯薬出版(株)

  35. Transplantation of lineage-negative stem cells in pterygopalatine artery ligation induced retinal ischemia-reperfusion injury in mice

    Gillipsie Minhas, Sudesh Prabhakar, Ryuichi Morishita, Munehisa Shimamura, Reema Bansal, Akshay Anand

    MOLECULAR AND CELLULAR BIOCHEMISTRY　Vol. 429　No. 1-2　p. 123-136　2017/05

  36. A peptide vaccine targeting angiotensin II attenuates the cardiac dysfunction induced by myocardial infarction

    Ryo Watanabe, Jun-ichi Suzuki, Kouji Wakayama, Yasuhiro Maejima, Munehisa Shimamura, Hiroshi Koriyama, Hironori Nakagami, Hidetoshi Kumagai, Yuichi Ikeda, Hiroshi Akazawa, Ryuichi Morishita, Issei Komuro, Mitsuaki Isobe

    SCIENTIFIC REPORTS　Vol. 7　2017/03

  37. New treatment

    Munehisa Shimamura, Hironori Nakagami, Kouji Wakayama, Tomohiro Kawano, Hideki Mochizuki, Ryuichi Morishita

    STROKE　Vol. 48　2017/02　Research paper, summary (international conference)

  38. S100A9タンパク質を標的とした新規抗血栓ワクチンによる脳梗塞予防法の開発

    河野友裕, 島村宗尚, 島村宗尚, 中神啓徳, 郡山弘, 佐々木勉, 坂口学, 楽木宏実, 望月秀樹

    日本心血管脳卒中学会学術集会プログラム・抄録集　Vol. 4th　2017

  39. S100A9タンパク質を標的とした新規抗血栓ワクチンによる脳梗塞予防法の開発

    河野友裕, 島村宗尚, 中神啓徳, 郡山弘, 佐々木勉, 森下竜一, 望月秀樹

    Anti-Aging Science　Vol. 9　No. 2　2017

  40. Evaluating the potential of the GFAP-KLH immune-tolerizing vaccine for type 1 diabetes in mice

    Zhengda Pang, Masayoshi Higuchi, Hiroshi Koriyama, Shota Yoshida, Hitomi Kurinami, Munehisa Shimamura, Yoichi Takami, Hiromi Rakugi, Ryuichi Morishita, Hironori Nakagami

    FEBS LETTERS　Vol. 591　No. 1　p. 129-136　2017/01

  41. NOVEL THERAPEUTIC APPROACH FOR CEREBRAL ISCHEMIA IN RATS WITH ANGIOTENSIN II PEPTIDE VACCINE

    Hironori Nakagami, Kouji Wakayama, Munehisa Shimamura, Jun-ichi Suzuki, Ryo Watanabe, Hiroshi Koriyama, Mitsuaki Isobe, Hiromi Rakugi, Ryuichi Morishita

    JOURNAL OF HYPERTENSION　Vol. 34　p. E408-E408　2016/09　Research paper, summary (international conference)

  42. Current therapies and investigational drugs for peripheral arterial disease

    Jun-ichi Suzuki, Munehisa Shimamura, Hiroyuki Suda, Kouji Wakayama, Hidetoshi Kumagai, Yuichi Ikeda, Hiroshi Akazawa, Mitsuaki Isobe, Issei Komuro, Ryuichi Morishita

    HYPERTENSION RESEARCH　Vol. 39　No. 4　p. 183-191　2016/04　Book review, literature introduction, etc.

  43. Therapeutic Application of an Angiotensin II Peptide Vaccine in a Middle Cerebral Artery Occlusion Model in Rats

    Kouji Wakayama, Munehisa Shimamura, Jun-ichi Suzuki, Mitsuaki Isobe, Hironori Nakagami, Ryuichi Morishita

    STROKE　Vol. 47　2016/02　Research paper, summary (international conference)

  44. 【血管病としての認知症〜予防はどこまで可能か?〜】脳血管のアンチエイジングと認知症予防

    島村 宗尚, 中神 啓徳, 里 直行, 望月 秀樹, 森下 竜一

    分子脳血管病　Vol. 15　No. 1　p. 14-18　2016/01

    Publisher: (株)先端医学社

  45. A model of stroke and vascular injury in the brain

    Munehisa Shimamura, Hironori Nakagami, Masataka Sata, Hitomi Kurinami, Kouji Wakayama, Hideki Mochizuki, Ryuichi Morishita

    Mouse Models of Vascular Diseases　p. 263-274　2016/01/01

    Publisher: Springer Japan

  46. 【老化を科学する】糖尿病・脂質異常症と認知症

    島村 宗尚, 里 直行, 中神 啓徳, 望月 秀樹, 森下 竜一

    最新精神医学　Vol. 20　No. 6　p. 517-524　2015/11

    Publisher: (株)世論時報社

  47. Long-Term Reduction of High Blood Pressure by Angiotensin II DNA Vaccine in Spontaneously Hypertensive Rats

    Hiroshi Koriyama, Hironori Nakagami, Futoshi Nakagami, Mariana Kiomy Osako, Mariko Kyutoku, Munehisa Shimamura, Hitomi Kurinami, Tomohiro Katsuya, Hiromi Rakugi, Ryuichi Morishita

    HYPERTENSION　Vol. 66　No. 1　p. 167-174　2015/07

  48. 【内科医が知っておくべき認知症・せん妄・うつの特徴と鑑別】高血圧・糖尿病と認知症・うつ・せん妄

    栗波 仁美, 島村 宗尚, 里 直行, 森下 竜一

    Mebio　Vol. 32　No. 6　p. 4-13　2015/06

    Publisher: (株)メジカルビュー社

  49. 脳血管傷害後のリモデリング過程の解析-頭蓋外血管との比較-

    島村宗尚, 島村宗尚, 中神啓徳, 郡山弘, 佐田政隆, 森下竜一

    日本高血圧学会総会プログラム・抄録集　Vol. 38th　2015

  50. 【各国の治療ガイドラインからみたRAS抑制薬の位置づけ】高齢者(認知症を含む)におけるRAS抑制薬の位置づけ

    島村 宗尚, 里 直行, 中神 啓徳, 森下 竜一

    Angiotensin Research　Vol. 12　No. 1　p. 43-49　2015/01

    Publisher: (株)先端医学社

  51. Modeling transient retinal ischemia in mouse by ligation of pterygopalatine artery

    Gillipsie Minhas, Ryuichi Morishita, Munehisa Shimamura, Reema Bansal, Akshay Anand

    Annals of Neurosciences　Vol. 22　No. 4　p. 222-225　2015

    Publisher: Indian Academy of Neurosciences

  52. Gene therapy for peripheral arterial disease

    Munehisa Shimamura, Hironori Nakagami, Yoshiaki Taniyama, Ryuichi Morishita

    EXPERT OPINION ON BIOLOGICAL THERAPY　Vol. 14　No. 8　p. 1175-1184　2014/08　Book review, literature introduction, etc.

  53. 【最新臨床脳卒中学[上]-最新の診断と治療-】治療戦略を目指した研究 基礎研究 脳梗塞治療標的分子細胞外基質ペリオスチン

    島村 宗尚, 谷山 義明, 中神 啓徳, 森下 竜一

    日本臨床　Vol. 72　No. 増刊5 最新臨床脳卒中学(上)　p. 423-427　2014/07

    Publisher: (株)日本臨床社

  54. The dipeptidyl peptidase-4 inhibitor teneligliptin improved endothelial dysfunction and insulin resistance in the SHR/NDmcr-cp rat model of metabolic syndrome

    Hironori Nakagami, Zhengda Pang, Takashi Shimosato, Toshinori Moritani, Hitomi Kurinami, Hiroshi Koriyama, Akiko Tenma, Munehisa Shimamura, Ryuichi Morishita

    HYPERTENSION RESEARCH　Vol. 37　No. 7　p. 629-635　2014/07

  55. Research for Localized High-Efficient Gene Transfer by the Magnetic Force Control Using High Temperature Superconducting Bulk Magnet

    Junya Tamada, Yoshihiro Oaku, Fumihito Mishima, Yoko Akiyama, Mariana KiomyOsako, Munehisa Shimamura, Hironori Nakagami, Shigehiro Nishijima

    IEEE TRANSACTIONS ON APPLIED SUPERCONDUCTIVITY　Vol. 24　No. 3　2014/06

  56. Possible modification of Alzheimer's disease by statins in nnidlife: interactions with genetic and non-genetic risk factors

    Mitsuru Shinohara, Naoyuki Sato, Munehisa Shimamura, Hitomi Kurinami, Toshimitsu Hamasaki, Amarnath Chatterjee, Hiromi Rakugi, Ryuichi Morishita

    FRONTIERS IN AGING NEUROSCIENCE　Vol. 6　2014/04　Book review, literature introduction, etc.

  57. Therapeutic vaccine against DPP4 improves glucose metabolism in mice

    Zhengda Pang, Hironori Nakagami, Mariana K. Osako, Hiroshi Koriyama, Futoshi Nakagami, Hideki Tomioka, Munehisa Shimamura, Hitomi Kurinami, Yoichi Takami, Ryuichi Morishita, Hiromi Rakugi

    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　Vol. 111　No. 13　p. E1256-E1263　2014/04

  58. Abetaの沈着は脳梗塞慢性期の微小循環に影響を及ぼす

    栗波仁美, 島村宗尚, 中神啓徳, 森下竜一

    日本抗加齢医学会総会プログラム・抄録集　Vol. 14th　2014

  59. アンジオテンシンIIを標的としたワクチンによる高血圧症の新規治療法の開発

    郡山弘, 中神啓徳, 島村宗尚, 栗波仁美, 勝谷友宏, 楽木宏実, 森下竜一

    日本抗加齢医学会総会プログラム・抄録集　Vol. 14th　2014

  60. プロヒビチン遺伝子導入により虚血後の海馬機能障害が改善する

    栗波仁美, 島村宗尚, 中神啓徳, 森下竜一

    Anti-Aging Science　Vol. 6　No. 3　2014

  61. Development of novel DNA vaccine for VEGF in murine cancer model

    Mariko Kyutoku, Hironori Nakagami, Hiroshi Koriyama, Hideki Tomioka, Futoshi Nakagami, Munehisa Shimamura, Hitomi Kurinami, Pang Zhengda, Dong Hyun Jo, Jeong Hun Kim, Nobuyuki Takakura, Ryuichi Morishita

    SCIENTIFIC REPORTS　Vol. 3　2013/11

  62. 脳血管性認知症 2.脳のアンチエイジング

    島村宗尚, 中神啓徳, 里直行, 森下竜一

    Anti Aging Sci　Vol. 5　No. 2　p. 82-88　2013/06/25

  63. Do Angiotensin Receptor Blockers Protect Against Alzheimer's Disease?

    Hitomi Kurinami, Munehisa Shimamura, Naoyuki Sato, Hironori Nakagami, Ryuichi Morishita

    DRUGS & AGING　Vol. 30　No. 6　p. 367-372　2013/06

  64. Cross-Talk of Receptor Activator of Nuclear Factor-kappa B Ligand Signaling With Renin-Angiotensin System in Vascular Calcification

    Mariana Kiomy Osako, Hironori Nakagami, Munehisa Shimamura, Hiroshi Koriyama, Futoshi Nakagami, Hideo Shimizu, Takashi Miyake, Masao Yoshizumi, Hiromi Rakugi, Ryuichi Morishita

    ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY　Vol. 33　No. 6　p. 1287-+　2013/06

  65. Inhibition of Neointima Formation through DNA Vaccination for Apolipoprotein(a): A New Therapeutic Strategy for Lipoprotein(a)

    Mariko Kyutoku, Hironori Nakagami, Hiroshi Koriyama, Futoshi Nakagami, Munehisa Shimamura, Hitomi Kurinami, Hideki Tomioka, Takashi Miyake, Tomohiro Katsuya, Ryuichi Morishita

    SCIENTIFIC REPORTS　Vol. 3　2013/04

  66. Plasmid DNA-based gene therapy in neurological disorders

    Munehisa Shimamura, Hironori Nakagami, Hitomi Kurinami, Naoyuki Sato, Ryuichi Morishita

    Gene Therapy: Technologies and Applications　p. 47-56　2013/03/01

    Publisher: Future Medicine Ltd.

  67. Decrease in Blood Pressure and Regression of Cardiovascular Complications by Angiotensin II Vaccine in Mice

    Futoshi Nakagami, Hiroshi Koriyama, Hironori Nakagami, Mariana Kiomy Osako, Munehisa Shimamura, Mariko Kyutoku, Takashi Miyake, Tomohiro Katsuya, Hiromi Rakugi, Ryuichi Morishita

    PLOS ONE　Vol. 8　No. 3　2013/03

  68. 頭蓋外血管と比較した頭蓋内動脈傷害におけるリモデリング過程の解析

    島村宗尚, 中神啓徳, 佐田政隆, 若山幸示, 栗波仁美, 森下竜一

    日本神経学会学術大会プログラム・抄録集　Vol. 54th　2013

  69. マウスモデルを用いた頭蓋内血管傷害におけるリモデリング過程の解析

    島村宗尚, 中神啓徳, 里直行, 佐田政隆, 栗波仁美, 森下竜一

    日本老年医学会雑誌　Vol. 50　2013

  70. Chronic deposition of Aβ influences microcirculation in the chronic stage of cerebral Ischemia

    Munehisa Shimamura, Naoyuki Sato, Hironori Nakagami, Mariana Kiomy Osako, Mariko Kyutoku, Kouji Wakayama, Ryuichi Morishita

    Immunology, Endocrine and Metabolic Agents in Medicinal Chemistry　Vol. 13　No. 1　p. 77-80　2013

  71. Rosuvastatin ameliorates obesity and proteinuria in zucker diabetic fatty rats

    Hironori Nakagami, Takashi Shimosato, Munehisa Shimamura, Ryuichi Morishita

    Immunology, Endocrine and Metabolic Agents in Medicinal Chemistry　Vol. 13　No. 2　p. 144-149　2013

  72. Gene Therapy and Cell-Based Therapies for Therapeutic Angiogenesis in Peripheral Artery Disease

    Munehisa Shimamura, Hironori Nakagami, Hiroshi Koriyama, Ryuichi Morishita

    BIOMED RESEARCH INTERNATIONAL　Vol. 2013　2013　Book review, literature introduction, etc.

  73. From Bench To Bedside(第25回)ペリオスチンの機能と脳梗塞治療への応用

    島村 宗尚, 谷山 義明, 中神 啓徳

    Vascular medicine : journal of vascular medicine　Vol. 8　No. 2　p. 158-163　2012/10

    Publisher: 先端医学社

  74. 成因 (特集 生活習慣病と認知症 : 負の連鎖を断ち切るために) -- (高血圧)

    島村 宗尚, 里 直行, 森下 竜一

    Medicinal = メディシーナル : 生活習慣病の薬物療法・治療薬を中心とする臨床医学誌　Vol. 2　No. 9　p. 19-26　2012/09

    Publisher: 医学出版

  75. 内科疾患と脳神経疾患:診断と治療の進歩 V.生活習慣病と認知症

    島村宗尚, 里直行, 森下竜一

    日本内科学会雑誌　Vol. 101　No. 8　p. 2204-2211　2012/08/10

    Publisher: The Japanese Society of Internal Medicine

  76. Ultrasound microbubbles and needleless jet injector for gene transfer of naked plasmid dna

    Munehisa Shimamura, Hironori Nakagami, Naoyuki Sato, Yoshiaki Taniyama, Yasuo Kunigiza, Ryuichi Morishita

    Plasmids: Genetics, Applications and Health　p. 137-147　2012/08/01

  77. HIG1, a novel regulator of mitochondrial gamma-secretase, maintains normal mitochondrial function

    Hiroki Hayashi, Hironori Nakagami, Makiko Takeichi, Munehisa Shimamura, Nobutaka Koibuchi, Eiji Oiki, Naoyuki Sato, Hiroshi Koriyama, Masaki Mori, Rodriguez Gerardo Araujo, Akito Maeda, Ryuichi Morishita, Katsuto Tamai, Yasufumi Kaneda

    FASEB JOURNAL　Vol. 26　No. 6　p. 2306-2317　2012/06

  78. 後天的危険因子に着目したアルツハイマー病の新規診断・治療法の開発

    武田朱公, 里直行, 内尾(山田)こずえ, 島村宗尚, 湯久浩, 守口篤, 楽木宏実, 森下竜一

    精神薬療研究年報　No. 44　p. 85-86　2012/03/21

    Publisher: (公財)先進医薬研究振興財団

  79. 脳虚血における細胞外マトリックスペリオスチンの機能解明

    島村宗尚, 谷山義明, 中神啓徳, 里直行, 森下竜一

    日本老年医学会雑誌　Vol. 49　2012

  80. 動脈硬化危険因子Lp(a)に対するapo(a)DNAワクチン治療効果の検討

    久徳真梨子, 久徳真梨子, 中神啓徳, 郡山弘, 郡山弘, 大窄マリアナ今日美, 島村宗尚, 栗波仁美, 栗波仁美, ほう正達, 冨岡英樹, 冨岡英樹, 森下竜一

    Anti-Aging Science　Vol. 4　No. 3　2012

  81. カルシウム拮抗薬ベニジピンの骨形成促進と骨吸収抑制による骨代謝改善作用について

    志水秀郎, 中神啓徳, 島村宗尚, 楠博, 尾崎和成, 森下竜一

    日本抗加齢医学会総会プログラム・抄録集　Vol. 12th　2012

  82. マウスを用いた脳梗塞におけるペリオスチンの機能解析

    島村宗尚, 谷山義明, 中神啓徳, 三宅隆, 大迫マリアナ, 郡山弘, 鯉渕信孝, 若山幸示, 森下竜一

    日本高血圧学会総会プログラム・抄録集　Vol. 35th　2012

  83. Nifedipine prevents hepatic fibrosis in a non-alcoholic steatohepatitis model induced by an L-methionine-and choline-deficient diet

    Hironori Nakagami, Munehisa Shimamura, Takashi Miyake, Takashi Shimosato, Noriko Minobe, Toshinori Moritani, Mariana Kiomy Osako, Futoshi Nakagami, Hiroshi Koriyama, Mariko Kyutoku, Hideo Shimizu, Tomohiro Katsuya, Ryuichi Morishita

    MOLECULAR MEDICINE REPORTS　Vol. 5　No. 1　p. 37-40　2012/01

  84. Cilnidipine, but not amlodipine, ameliorates osteoporosis in ovariectomized hypertensive rats through inhibition of the N-type calcium channel

    Hideo Shimizu, Hironori Nakagami, Natsuki Yasumasa, Osako Kiomy Mariana, Mariko Kyutoku, Hiroshi Koriyama, Futoshi Nakagami, Munehisa Shimamura, Hiromi Rakugi, Ryuichi Morishita

    HYPERTENSION RESEARCH　Vol. 35　No. 1　p. 77-81　2012/01

  85. Pitavastatin improves endothelial function and glucose metabolism in ovariectomized mice

    Hironori Nakagami, Mariana Kiomy Osako, Natsuki Yasumasa, Munehisa Shimamura, Mariko Kyutoku, Futoshi Nakagami, Hiroshi Koriyama, Hideki Tomioka, Tomohiro Katsuya, Ryuichi Morishita

    Immunology, Endocrine and Metabolic Agents in Medicinal Chemistry　Vol. 12　No. 1　p. 29-33　2012

    Publisher: Bentham Science Publishers B.V.

  86. Lipoprotein(a) is a therapeutic target for cardiovascular disease

    Mariko Kyutoku, Hironori Nakagami, Futoshi Nakagami, Hiroshi Koriyama, Mariana Kiomy Osako, Munehisa Shimamura, Takashi Miyake, Ryuichi Morishita

    Immunology, Endocrine and Metabolic Agents in Medicinal Chemistry　Vol. 12　No. 2　p. 118-121　2012　Book review, literature introduction, etc.

    Publisher: Bentham Science Publishers B.V.

  87. Screening of antihypertensive drugs for osteoclastic acid secretion and bone resorption by acridine orange

    Hideo Shimizu, Hironori Nakagami, Natsuki Yasumasa, Osako Kiomy Mariana, Mariko Kyutoku, Hiroshi Koriyama, Futoshi Nakagami, Munehisa Shimamura, Hiromi Rakugi, Ryuichi Morishita

    Immunology, Endocrine and Metabolic Agents in Medicinal Chemistry　Vol. 12　No. 3　p. 161-167　2012

    Publisher: Bentham Science Publishers B.V.

  88. [Internal medicine and neurological diseases: progress in diagnosis and treatment. Topics: V. Dementia and life-style related disease].

    Munehisa Shimamura, Naoyuki Sato, Ryuichi Morishita

    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine　Vol. 101　p. 2204-2211　2012/01/01

  89. Development of nucleic acid drugs for neurological disorders

    Munehisa Shimamura, Naoyuki Sato, Hironori Nakagami, Yoshiaki Taniyama, Ryuichi Morishita

    Current Topics in Medicinal Chemistry　Vol. 12　No. 15　p. 1621-1629　2012　Book review, literature introduction, etc.

  90. Links Between Hypertension and Osteoporosis: Benidipine Ameliorates Osteoporosis in Ovariectomized Hypertensive Rats Through Promotion of Osteoblast Proliferation and Inhibition of Osteoclast Differentiation

    Hideo Shimizu, Hironori Nakagami, Natsuki Yasumasa, Osako Kiyomy Mariana, Mariko Kyutoku, Hiroshi Koriyama, Futoshi Nakagami, Munehisa Shimamura, Hiromi Rakugi, Ryuichi Morishita

    Current Cardiovascular Risk Reports　Vol. 6　No. 4　p. 274-280　2012　Book review, literature introduction, etc.

  91. Experimental and Clinical Application of Plasmid DNA in the Field of Central Nervous Diseases

    Munehisa Shimamura, Naoyuki Sato, Ryuichi Morishita

    CURRENT GENE THERAPY　Vol. 11　No. 6　p. 491-500　2011/12　Book review, literature introduction, etc.

  92. Naked Plasmid DNA for Gene Therapy

    Munehisa Shimamura, Ryuichi Morishita

    CURRENT GENE THERAPY　Vol. 11　No. 6　p. 433-433　2011/12　Other

  93. スタチンのベータ・アミロイドに対する特異的な作用―アルツハイマー病予防の可能性

    里直行, 篠原充, 島村宗尚, 楽木宏実, 森下竜一

    Anti Aging Sci　Vol. 3　2011/11/30

  94. Prevention of Neointimal Hyperplasia After Angioplasty Using NF-kappaB Decoy Oligodeoxynucleotides-Coated Balloon Catheter in Rabbit Restenosis Model

    Takashi Miyake, Munehisa Shimamura, Hironori Nakagami, Ryuichi Morishita

    CIRCULATION　Vol. 124　No. 21　2011/11　Research paper, summary (international conference)

  95. Irbesartan improves endothelial dysfunction, abnormal lipid profile, proteinuria and liver dysfunction in Zucker diabetic fatty rats independent of glucose and insulin levels

    Munehisa Shimamura, Hironori Nakagami, Takashi Shimosato, Toshinori Moritani, Futoshi Nakagami, Mariana Kiomy Osako, Takashi Miyake, Hiroshi Koriyama, Hideo Shimizu, Ryuichi Morishita

    EXPERIMENTAL AND THERAPEUTIC MEDICINE　Vol. 2　No. 5　p. 957-961　2011/09

  96. Systemic Administration of Ribbon-type Decoy Oligodeoxynucleotide Against Nuclear Factor kappa B and Ets Prevents Abdominal Aortic Aneurysm in Rat Model

    Takashi Miyake, Motokuni Aoki, Mariana K. Osako, Munehisa Shimamura, Hironori Nakagami, Ryuichi Morishita

    MOLECULAR THERAPY　Vol. 19　No. 1　p. 181-187　2011/01

  97. [Gene therapy for diabetic microangiopathy].

    Munehisa Shimamura, Ryuichi Morishita

    Nippon rinsho. Japanese journal of clinical medicine　Vol. 68 Suppl 9　p. 207-211　2010/11/01

  98. Prevention and regression of non-alcoholic steatohepatitis (NASH) in a rat model by metabosartan, telmisartan

    Hironori Nakagami, Mariana Kiomy Osako, Futoshi Nakagami, Takashi Shimosato, Noriko Minobe, Toshinori Moritani, Munehisa Shimamura, Takashi Miyake, Hideo Shimizu, Yasushi Takeya, Ryuichi Morishita

    INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE　Vol. 26　No. 4　p. 477-481　2010/10

  99. Estrogen Inhibits Vascular Calcification via Vascular RANKL System Common Mechanism of Osteoporosis and Vascular Calcification

    Mariana Kiomy Osako, Hironori Nakagami, Nobutaka Koibuchi, Hideo Shimizu, Futoshi Nakagami, Hiroshi Koriyama, Munehisa Shimamura, Takashi Miyake, Hiromi Rakugi, Ryuichi Morishita

    CIRCULATION RESEARCH　Vol. 107　No. 4　p. 466-U57　2010/08

  100. Estrogen attenuates vascular remodeling in Lp(a) transgenic mice

    Futoshi Nakagami, Hironori Nakagami, Mariana Kiomy Osako, Masaaki Iwabayashi, Yoshiaki Taniyama, Takefumi Doi, Hideo Shimizu, Munehisa Shimamura, Hiromi Rakugi, Ryuichi Morishita

    ATHEROSCLEROSIS　Vol. 211　No. 1　p. 41-47　2010/07

  101. Reduction of Brain beta-Amyloid (A beta) by Fluvastatin, a Hydroxymethylglutaryl-CoA Reductase Inhibitor, through Increase in Degradation of Amyloid Precursor Protein C-terminal Fragments (APP-CTFs) and A beta Clearance

    Mitsuru Shinohara, Naoyuki Sato, Hitomi Kurinami, Daisuke Takeuchi, Shuko Takeda, Munehisa Shimamura, Toshihide Yamashita, Yasuo Uchiyama, Hiromi Rakugi, Ryuichi Morishita

    JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 285　No. 29　p. 22091-22102　2010/07

  102. 動脈瘤の進展における慢性腎障害の影響

    三宅隆, 浜田日月, 島村宗尚, 中神啓徳, 森下竜一

    日本血管生物医学会学術集会プログラム・抄録集　Vol. 18th　2010

  103. 核酸医薬の全身投与による転写因子NF-kappaBとEtsの抑制が腹部大動脈瘤に及ぼす影響

    三宅隆, 島村宗尚, 中神啓徳, 森下竜一

    日本血管生物医学会学術集会プログラム・抄録集　Vol. 18th　2010

  104. Combination of thiazide diuretics and angiotensin receptor blockers attenuates osteoporosis in hypertensive rats

    Hideo Shimizu, Hironori Nakagami, Natsuki Yasumasa, Mariana Kiomy Osako, Munehisa Shimamura, Takeshi Miyake, Futoshi Nakagami, Hiroshi Koriyama, Hiromi Rakugi, Ryuichi Morishita

    Immunology, Endocrine and Metabolic Agents in Medicinal Chemistry　Vol. 10　No. 3　p. 115-122　2010

    Publisher: Bentham Science Publishers B.V.

  105. The neuroprotective effect of prostaglandin E2 EP1 receptor inhibition has a wide therapeutic window, is sustained in time and is not sexually dimorphic

    Takato Abe, Alexander Kunz, Munehisa Shimamura, Ping Zhou, Josef Anrather, Costantino Iadecola

    JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM　Vol. 29　No. 1　p. 66-72　2009/01

  106. Injection of HGF plasmid cDNA to prevent manifestation of Parkinson disease: A preclinical study using a primate model

    Hiromi Koike, Akihiko Ishida, Takuya Hayashi, Munehisa Shimamura, Shinya Mizuno, Toshikazu Nakamura, Hidehiro Iida, Toshio Ogihara, Yasufumi Kaneda, Ryuichi Morishita

    Open Gene Therapy Journal　Vol. 2　p. 38-44　2009

  107. Prevention of amyloid ss-induced memory impairment by fluvastatin, associated with the decrease in amyloid ss accumulation and oxidative stress in amyloid ss injection mouse model

    Hitomi Kurinami, Naoyuki Sato, Mitsuru Shinohara, Daisuke Takeuchi, Shuko Takeda, Munehisa Shimamura, Toshio Ogihara, Ryuichi Morishita

    INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE　Vol. 21　No. 5　p. 531-537　2008/05

  108. Alleviation of A beta-induced cognitive impairment by ultrasound-mediated gene transfer of HGF in a mouse model

    D. Takeuchi, N. Sato, M. Shimamura, H. Kurinami, S. Takeda, M. Shinohara, S. Suzuki, M. Kojima, T. Ogihara, R. Morishita

    GENE THERAPY　Vol. 15　No. 8　p. 561-571　2008/04

  109. Expression of hepatocyte growth factor and c-Met after spinal cord injury in rats

    Munehisa Shimamura, Naoyuki Sato, Masataka Sata, Kouji Wakayama, Toshio Ogihara, Ryuichi Morishita

    BRAIN RESEARCH　Vol. 1151　p. 188-194　2007/06

  110. Gene therapy for ischemic brain disease with special reference to vascular dementia

    SATO Naoyuki, SHIMAMURA Munehisa, TAKEUCHI Daisuke, KURINAMI Hitomi, OGIHARA Toshio, MORISHITA Ryuichi

    Vol. 7　No. 1　p. 1-14　2007/03/01

  111. OJ-094 Delayed Post-ischemic Treatment with Fluvastatin Improved Learning and Memory Deficit After Stroke in Rats without affecting Infarction Volume(Cerebrovascular circulation / Stroke-1, The 71st Annual Scientific Meeting of the Japanese Circulation Society)

    Shimamura Munehisa, Sato Naoyuki, Sata Masataka, Wakayama Kouji, Hayashi Takuya, Iida Hidehiro, Ogihara Toshio, Morishita Ryuichi

    Circulation journal : official journal of the Japanese Circulation Society　Vol. 71　p. 277-277　2007/03/01

    Publisher: Japanese Circulation Society

  112. Prevention of onset of Parkinson's disease by in vivo gene transfer of human hepatocyte growth factor in rodent model: a model of gene therapy for Parkinson's disease

    H. Koike, A. Ishida, M. Shimamura, S. Mizuno, T. Nakamura, T. Ogihara, Y. Kaneda, R. Morishita

    GENE THERAPY　Vol. 13　No. 23　p. 1639-1644　2006/12

  113. Development of new screening system for Alzheimer disease, in vitro A beta sink assay, to identify the dissociation of soluble A beta from fibrils

    N Sato, M Okochi, Y Taniyama, H Kurinami, M Shimamura, D Takeuchi, H Hamada, A Fukumori, K Kiyosue, T Taguchi, T Tanaka, M Miyasaka, M Takeda, T Ogihara, R Morishita

    NEUROBIOLOGY OF DISEASE　Vol. 22　No. 3　p. 487-495　2006/06

  114. PJ-652 Over-expression of HGF Improves Learning and Memory and Prevents Progressive Shrinkage of Thalamus in the Chronic Stage of Cerebral Infarction(Cerebrovascular circulation/Stroke-3 (H) PJ110,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)

    Shimamura Munehisa, Sato Naoyuki, Hayashi Takuya, Iida Hidehiro, Nakamura Toshikazu, Kaneda Yasufumi, Ogihara Toshio, Morishita Ryuichi

    Circulation journal : official journal of the Japanese Circulation Society　Vol. 70　p. 651-651　2006/03/01

    Publisher: Japanese Circulation Society

  115. HVJ-based non-viral gene transfer method: Successful gene therapy using HGF and VEGF genes in experimental ischemia

    Munehisa Shimamura, Naoyuki Sato, Shinichi Yoshimura, Yasufumi Kaneda, Ryuichi Morishita

    Frontiers in Bioscience　Vol. 11　No. 1　p. 753-759　2006　Book review, literature introduction, etc.

  116. Gene transfer into adult rat spinal cord using naked plasmid DNA and ultrasound microbubbles

    M Shimamura, N Sato, Y Taniyama, H Kurinami, H Tanaka, T Takami, T Ogihara, M Tohyama, Y Kaneda, R Morishita

    JOURNAL OF GENE MEDICINE　Vol. 7　No. 11　p. 1468-1474　2005/11

  117. Gene transfer of HGF gene improves learning and memory in the chronic stage of cerebral infarction

    M Shimamura, N Sato, M Aoki, S Waguri, T Hayashi, T Ogihara, Y Kaneda, R Morishita

    CIRCULATION　Vol. 112　No. 17　p. U336-U337　2005/10　Research paper, summary (international conference)

  118. Recent progress in cerebrovascular gene therapy

    N Sato, M Shimamura, R Morishita

    CURRENT NEUROVASCULAR RESEARCH　Vol. 2　No. 3　p. 235-247　2005/07　Book review, literature introduction, etc.

  119. Recovery of Learning and Memory by Gene Therapy Using Hepatocyte Growth Factor Gene After Focal Cerebral Ishcemia in Rats(Gene Therapy/Genetic Engineering (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)

    Shimamura Munehisa, Sato Naoyuki, Aoki Motokuni, Waguri Satoshi, Uchiyama Yasuo, Matsumoto Kunio, Hayashi Takuya, Iida Hidehiro, Nakamura Toshikazu, Kaneda Yasufumi, Ogihara Toshio, Morishita Ryuichi

    Circulation journal : official journal of the Japanese Circulation Society　Vol. 69　p. 306-306　2005/03/01

    Publisher: Japanese Circulation Society

  120. HGF遺伝子を用いた脳梗塞後における記憶障害に対する遺伝子治療の検討

    島村 宗尚, 里 直行, 青木 元邦, 和栗 聡, 内山 安男, 林 拓也, 飯田 秀博, 金田 安史, 荻原 俊男, 森下 竜一

    日本高血圧学会総会プログラム・抄録集　Vol. 27回　p. 44-44　2004/10

    Publisher: (NPO)日本高血圧学会

  121. Development of efficient plasmid DNA transfer into adult rat central nervous system using microbubble-enhanced ultrasound

    M Shimamura, N Sato, Y Taniyama, S Yamamoto, M Endoh, H Kurinami, M Aoki, T Ogihara, Y Kaneda, R Morishita

    GENE THERAPY　Vol. 11　No. 20　p. 1532-1539　2004/10

  122. A novel therapeutic strategy to treat brain ischemia: Over-expression of hepatocyte growth factor gene reduced ischemic injury without cerebral edema in rat model

    M Shimamura, N Sato, T Ogihara, Y Kaneda, R Morishita

    MOLECULAR THERAPY　Vol. 9　p. S88-S88　2004/05　Research paper, summary (international conference)

  123. Prevention of onset of Parkinson's disease by in vivo gene transfer of human hepatocyte growth factor in primate model: A model of gene therapy for Parkinson's disease

    H Koike, A Ishida, M Shimamura, N Sato, N Tomita, Y Kaneda, R Morishita

    MOLECULAR THERAPY　Vol. 9　p. S196-S196　2004/05　Research paper, summary (international conference)

  124. PJ-477 A Therapeutic Strategy to Treat Brain Ischemia : Over-expression of Hepatocyte Growth Factor Gene Reduced Ischemic Injury in Rat Model(Cerebrovascular Circulation/Stroke 1 (H) : PJ80)(Poster Session (Japanese))

    Shimamura Munehisa, Sato Naoyuki, Kurinami Hitomi, Aoki Motokuni, Kaneda Yasufumi, Ogihara Toshio, Morishita Ryuichi

    Circulation journal : official journal of the Japanese Circulation Society　Vol. 68　p. 597-597　2004/03/01

    Publisher: Japanese Circulation Society

  125. A novel therapeutic strategy to treat brain ischemia: over-expression of hepatocyte growth factor gene reduced ischemic injury without brain edema in rat model.

    M Shimamura, N Sato, M Aoki, S Waguri, Y Uchiyama, T Ogihara, Y Kaneda, R Morishita

    STROKE　Vol. 35　No. 1　p. 282-282　2004/01　Research paper, summary (international conference)

  126. Intrathecal injection of HVJ-E containing HGF gene to cerebrospinal fluid can prevent and ameliorate hearing impairment in rats

    K Oshima, M Shimamura, S Mizuno, K Tamai, K Doi, R Morishita, T Nakamura, T Kubo, Y Kaneda

    FASEB JOURNAL　Vol. 18　No. 1　p. 212-214　2004/01

  127. Modification of plasmid DNA-based gene transfer into central nerve system

    Y Taniyama, M Shimamura, N Sato, N Tomita, M Endho, J Azuma, K Iekushi, Y Kaneda, T Ogihara, R Monshita

    STATE OF THE ART: ULTRASONICS IN MEDICINE　Vol. 1274　p. 159-163　2004

  128. ラット中大脳動脈閉塞モデルにおける肝細胞増殖因子(HGF)遺伝子による遺伝子治療の検討

    島村 宗尚, 里 直行, 青木 元邦, 和栗 聡, 内山 安男, 金田 安史, 荻原 俊男, 森下 竜一

    日本高血圧学会総会プログラム・抄録集　Vol. 26回　p. 187-187　2003/10

    Publisher: (NPO)日本高血圧学会

  129. Gene Therapy for Cerebral Ischemia Using Hepatocyte Growth Factor (HGF)

    島村宗尚, 里直行, 青木元邦, 森下竜一

    Bio Ind　Vol. 20　No. 9　p. 5-10　2003/09/12

    Publisher: シーエムシー出版

  130. Overexpression of HGF (Hepatocyte Growth Factor) Reduced Ischemic Injury in Rat Permanent Middle Cerebral Artery Occlusion (MCAO) Model

    Shimamura Munehisa, Morishita Ryuichi, Aoki Motokuni, Ogihara Toshio, Kaneda Yasufumi

    Circulation journal : official journal of the Japanese Circulation Society　Vol. 67　p. 629-629　2003/03/01

    Publisher: Japanese Circulation Society

  131. Gene therapy for neurological diseases

    Munehisa Shimamura, Motokuni Aoki, Ryuichi Morishita

    Japanese Journal of Neurosurgery　Vol. 12　No. 3　p. 147-155　2003/03/01

    Publisher: Japanese Congress of Neurological Surgeons

  132. A unique case of sporadic Creutzfeldt-Jacob disease presenting as progressive supranuclear palsy

    M Shimamura, E Uyama, T Hirano, T Murakami, S Mita, T Kitamoto, M Uchino

    INTERNAL MEDICINE　Vol. 42　No. 2　p. 195-198　2003/02

  133. HVJ-envelope vector for gene transfer into central nervous system

    M Shimamura, R Morishita, M Endoh, K Oshima, M Aoki, S Waguri, Y Uchiyama, Y Kaneda

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 300　No. 2　p. 464-471　2003/01

  134. 基礎から臨床へ 動脈硬化の遺伝子治療

    島村 宗尚, 青木 元邦, 森下 竜一

    診断と治療　Vol. 90　No. 11　p. 2021-2028　2002/11

    Publisher: 診断と治療社

  135. Therapeutic angiogenesis using gene therapy

    Munehisa Shimamura, Motokuni Aoki, Ryuichi Morishita

    Respiration and Circulation　Vol. 50　No. 4　p. 341-347　2002/04/01

    Publisher: 医学書院

  136. Gene therapy for preventing delayed neuronal death using hepatocyte growth factor

    Shimamura Munehisa, Morishita Ryuichi, Kaneda Yasuhumi, Aoki Motokuni, Ogihara Toshio, Hayashi Katsuhiko, Yoshimura Shin-ichi

    Circulation journal : official journal of the Japanese Circulation Society　Vol. 66　p. 705-705　2002/03/31

    Publisher: Japanese Circulation Society

  137. 遺伝子治療はどこまで進むか (21世紀の医療と創薬--これからの医療・薬物療法はどう変わるか) -- (第1章 21世紀の医療)

    島村 宗尚, 青木 元邦, 森下 竜一

    月刊薬事　Vol. 44　No. 4　p. 618-626　2002/03

    Publisher: じほう

  138. Autosomal dominant proximal spinal muscular atrophy of adult-onset

    E Uyama, K Yamaguchi, M Shimamura, S Imamura, M Uchino

    NEUROMUSCULAR DISORDERS　Vol. 11　No. 6-7　p. 649-649　2001/09　Research paper, summary (international conference)

  139. A novel CLCN1 mutation: P480T in a Japanese family with Thomsen's myotonia congenita

    R Sasaki, N Ito, M Shimamura, T Murakami, S Kuzuhara, M Uchino, E Uyama

    MUSCLE & NERVE　Vol. 24　No. 3　p. 357-363　2001/03

  140. Hodgkin's disease preceded by unique neurological symptoms

    Munehisa Shimamura, Yuji Uchida, Tadashi Terasaki, Yoichiro Hashimoto, Hiroshi Yamasaki, Hiroyuki Tsuda, Tadashi Wakayama, Tetsuo Ando, Makoto Uchino

    Internal Medicine　Vol. 40　No. 8　p. 819-821　2001

    Publisher: Japanese Society of Internal Medicine

  141. Treatment for recurrent paradoxical brain embolism through the patent foramen ovale

    Munehisa Shimamura, Yoichiro Hashimoto, Satoshi Orita, Tadashi Terasaki, Makoto Uchino

    Brain and Nerve　Vol. 53　No. 4　p. 357-361　2001

  142. Cerebral embolism in systemic lupus erythematosus with Libman-Sacks endocarditis: A case report

    J. Kasuya, Y. Hashimoto, T. Terasaki, M. Shimamura, M. Uchino

    Clinical Neurology　Vol. 40　No. 7　p. 707-711　2000

Institutional Repository 3

Content Published in the University of Osaka Institutional Repository (OUKA)

  1. Development of a peptide-based vaccine using a T cell epitope derived from SARS-CoV-2

    Baba Satoshi, Hayashi Hiroki, Yoshida Shota, Yin Nanxiang, Shimamura Munehisa, Morishita Ryuichi, Rakugi Hiromi, Nakagami Hironori, Yamamoto Koichi

    iScience　Vol. 28　No. 6　2025/05/13

  2. RANKL-derived peptide MHP1-AcN attenuates ovariectomy-induced osteoporosis by targeting RANK and TNFR1 in mice

    Kurihara Takuya, Shimamura Munehisa, Etani Yuki, Noguchi Takaaki, Fukuda Yuji, Ochiai Nagahiro, Goshima Atsushi, Miura Taihei, Hirao Makoto, Sugimoto Atsushi, Ju Nan, Yamakawa Satoshi, Kanamoto Takashi, Nakata Ken, Okada Seiji, Ebina Kosuke

    Bone　Vol. 194　2025/05/01

  3. Novel Therapeutic Strategy to Treat Brain Ischemia Overexpression of Hepatocyte Growth Factor Gene Reduced Ischemic Injury Without Cerebral Edema in Rat Model

    島村 宗尚