EN

基本情報

研究

社会活動

その他の活動

山口 圭一

Yamaguchi Keiichi

工学研究科,特任准教授(常勤)

keyword フォールディング,生物物理,アミロイド線維

学歴

  • ~ 2003年,大阪大学,理学研究科,生物科学専攻

研究内容・専門分野

  • ライフサイエンス,生物物理学
  • ライフサイエンス,構造生物化学

論文

  • Mass spectrometry-based proteomic analysis of proteins adsorbed by hexadecyl-immobilized cellulose bead column for the treatment of dialysis-related amyloidosis.,Suguru Yamamoto,Keiko Yamamoto,Yoshitoshi Hirao,Keiichi Yamaguchi,Kichitaro Nakajima,Mami Sato,Miho Kawachi,Mio Domon,Kei Goto,Kentaro Omori,Noriaki Iino,Hisaki Shimada,Ryuzi Aoyagi,Isei Ei,Shin Goto,Yuji Goto,Fumitake Gejyo,Tadashi Yamamoto,Ichiei Narita,Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis,p. 1-11,2024年02月11日,研究論文(学術雑誌)
  • Supersaturation, a critical factor underlying proteostasis of amyloid fibril formation.,Yuji Goto,Kichitaro Nakajima,Suguru Yamamoto,Keiichi Yamaguchi,Journal of molecular biology,p. 168475-168475,2024年02月02日,研究論文(学術雑誌)
  • Ultrastiff Amyloid-Fibril Network of α-Synuclein Formed by Surface Seeding Reaction Confirmed by Multichannel Electrodeless Quartz-Crystal-Microbalance Biosensor,Lianjie Zhou,Touko Hajiri,Kichitaro Nakajima,César Aguirre,Kensuke Ikenaka,Hideki Mochizuki,Keiichi Yamaguchi,Yuji Goto,Hirotsugu Ogi,ACS Sensors,American Chemical Society (ACS),2023年06月26日,研究論文(学術雑誌)
  • Phosphatidylinositol-3,4,5-trisphosphate interacts with alpha-synuclein and initiates its aggregation and formation of Parkinson's disease-related fibril polymorphism.,Chi-Jing Choong,César Aguirre,Keita Kakuda,Goichi Beck,Hiroki Nakanishi,Yasuyoshi Kimura,Shuichi Shimma,Kei Nabekura,Makoto Hideshima,Junko Doi,Keiichi Yamaguchi,Kichitaro Nakajima,Tomoya Wadayama,Hideki Hayakawa,Kousuke Baba,Kotaro Ogawa,Toshihide Takeuchi,Shaymaa Mohamed Mohamed Badawy,Shigeo Murayama,Seiichi Nagano,Yuji Goto,Yohei Miyanoiri,Yoshitaka Nagai,Hideki Mochizuki,Kensuke Ikenaka,Acta neuropathologica,Vol. 145,No. 5,p. 573-595,2023年03月20日,研究論文(学術雑誌)
  • Mechanisms of polyphosphate-induced amyloid fibril formation triggered by breakdown of supersaturation,Keiichi Yamaguchi,Kichitaro Nakajima,Yuji Goto,Biophysics and Physicobiology,Biophysical Society of Japan,Vol. 20,No. 1,p. n/a-n/a,2023年,研究論文(学術雑誌)
  • The residual structure of acid‐denatured β <sub>2</sub> ‐microglobulin is relevant to an ordered fibril morphology,Ryosuke Tomiyama,Masatomo So,Keiichi Yamaguchi,Yohei Miyanoiri,Kazumasa Sakurai,Protein Science,Wiley,Vol. 32,No. 1,2022年11月,研究論文(学術雑誌)
  • Supersaturation-Dependent Formation of Amyloid Fibrils,Yuji Goto,Masahiro Noji,Kichitaro Nakajima,Keiichi Yamaguchi,Molecules,MDPI AG,Vol. 27,No. 14,p. 4588-4588,2022年07月19日,研究論文(学術雑誌)
  • Conformational change in the monomeric alpha-synuclein imparts fibril polymorphs,Cesar Aguirre,Kensuke Ikenaka,Masatomo So,Takahiro Maruno,Keiichi Yamaguchi,Kichitaro Nakajima,Chi-Jing Choong,Kei Nabekura,Goichi Beck,Kentaro Tomii,Yu Yamamori,Junko Doi,Tomoyasu Matsubara,Maho Morishima,Keita Kakuda,Makoto Hideshima,Yasuyoshi Kimura,Seiichi Nagano,Kousuke Baba,Shigeo Murayama,Hirotsugu Ogi,Yoshitaka Nagai,Yasushi Kawata,Susumu Uchiyama,Yohei Miyanoiri,Yuji Goto,Hideki Mochizuki,bioRxiv,Cold Spring Harbor Laboratory,2022年02月10日,研究論文(学術雑誌)
  • Macromolecular crowding and supersaturation protect hemodialysis patients from the onset of dialysis-related amyloidosis,Kichitaro Nakajima,Keiichi Yamaguchi,Masahiro Noji,César Aguirre,Kensuke Ikenaka,Hideki Mochizuki,Lianjie Zhou,Hirotsugu Ogi,Toru Ito,Ichiei Narita,Fumitake Gejyo,Hironobu Naiki,Suguru Yamamoto,Yuji Goto,Cold Spring Harbor Laboratory,2022年02月04日
  • Development of HANABI, an ultrasonication-forced amyloid fibril inducer,Yuji Goto,Kichitaro Nakajima,Keiichi Yamaguchi,Masatomo So,Kensuke Ikenaka,Hideki Mochizuki,Hirotsugu Ogi,Neurochemistry International,Elsevier BV,Vol. 153,p. 105270-105270,2022年02月,研究論文(学術雑誌)
  • Two-step screening method to identify α-synuclein aggregation inhibitors for Parkinson's disease.,Makoto Hideshima,Yasuyoshi Kimura,César Aguirre,Keita Kakuda,Toshihide Takeuchi,Chi-Jing Choong,Junko Doi,Kei Nabekura,Keiichi Yamaguchi,Kichitaro Nakajima,Kousuke Baba,Seiichi Nagano,Yuji Goto,Yoshitaka Nagai,Hideki Mochizuki,Kensuke Ikenaka,Scientific reports,Vol. 12,No. 1,p. 351-351,2022年01月10日,研究論文(学術雑誌)
  • Acceleration of amyloid fibril formation by multichannel sonochemical reactor,Kentaro Noi,Kichitaro Nakajima,Keiichi Yamaguchi,Masatomo So,Kensuke Ikenaka,Hideki Mochizuki,Yuji Goto,Hirotsugu OGI,Japanese Journal of Applied Physics,IOP Publishing,2021年12月08日,研究論文(学術雑誌)
  • Breakdown of supersaturation barrier links protein folding to amyloid formation,Masahiro Noji,Tatsushi Samejima,Keiichi Yamaguchi,Masatomo So,Keisuke Yuzu,Eri Chatani,Yoko Akazawa-Ogawa,Yoshihisa Hagihara,Yasushi Kawata,Kensuke Ikenaka,Hideki Mochizuki,József Kardos,Daniel E. Otzen,Vittorio Bellotti,Johannes Buchner,Yuji Goto,Communications Biology,Springer Science and Business Media LLC,Vol. 4,No. 1,2021年12月,研究論文(学術雑誌)
  • Strong acids induce amyloid fibril formation of β2-microglobulin via an anion-binding mechanism,Keiichi Yamaguchi,Kenshiro Hasuo,Masatomo So,Kensuke Ikenaka,Hideki Mochizuki,Yuji Goto,Journal of Biological Chemistry,Elsevier BV,Vol. 297,No. 5,p. 101286-101286,2021年11月,研究論文(学術雑誌)
  • Half-Time Heat Map Reveals Ultrasonic Effects on Morphology and Kinetics of Amyloidogenic Aggregation Reaction,Kichitaro Nakajima,Hajime Toda,Keiichi Yamaguchi,Masatomo So,Kensuke Ikenaka,Hideki Mochizuki,Yuji Goto,Hirotsugu Ogi,ACS Chemical Neuroscience,American Chemical Society (ACS),Vol. 12,No. 18,p. 3456-3466,2021年09月15日,研究論文(学術雑誌)
  • Polyphenol‐solubility alters amyloid fibril formation of α‐synuclein,Masatomo So,Yuto Kimura,Keiichi Yamaguchi,Toshihiko Sugiki,Toshimichi Fujiwara,Cesar Aguirre,Kensuke Ikenaka,Hideki Mochizuki,Yasushi Kawata,Yuji Goto,Protein Science,Wiley,Vol. 30,No. 8,p. 1701-1713,2021年08月,研究論文(学術雑誌)
  • Optimized sonoreactor for accelerative amyloid-fibril assays through enhancement of primary nucleation and fragmentation,Kichitaro Nakajima,Kentaro Noi,Keiichi Yamaguchi,Masatomo So,Kensuke Ikenaka,Hideki Mochizuki,Hirotsugu Ogi,Yuji Goto,Ultrasonics Sonochemistry,Elsevier BV,Vol. 73,p. 105508-105508,2021年05月,研究論文(学術雑誌)
  • pH-Dependent Protein Binding Properties of Uremic Toxins In Vitro,Suguru Yamamoto,Kenichi Sasahara,Mio Domon,Keiichi Yamaguchi,Toru Ito,Shin Goto,Yuji Goto,Ichiei Narita,Toxins,MDPI AG,Vol. 13,No. 2,p. 116-116,2021年02月04日,研究論文(学術雑誌)
  • Polyphosphates induce amyloid fibril formation of α-synuclein in concentration-dependent distinct manners,Keiichi Yamaguchi,Masatomo So,César Aguirre,Kensuke Ikenaka,Hideki Mochizuki,Yasushi Kawata,Yuji Goto,Journal of Biological Chemistry,Elsevier BV,Vol. 296,p. 100510-100510,2021年01月,研究論文(学術雑誌)
  • Amyloid Formation of α-Synuclein Based on the Solubility- and Supersaturation-Dependent Mechanism,Maya Sawada,Keiichi Yamaguchi,Miki Hirano,Masahiro Noji,Masatomo So,Daniel Otzen,Yasushi Kawata,Yuji Goto,Langmuir,American Chemical Society (ACS),Vol. 36,No. 17,p. 4671-4681,2020年05月05日,研究論文(学術雑誌)
  • Inorganic polyphosphate potentiates lipopolysaccharide-induced macrophage inflammatory response,Toru Ito,Suguru Yamamoto,Keiichi Yamaguchi,Mami Sato,Yoshikatsu Kaneko,Shin Goto,Yuji Goto,Ichiei Narita,Journal of Biological Chemistry,Elsevier BV,Vol. 295,No. 12,p. 4014-4023,2020年03月,研究論文(学術雑誌)
  • Isoelectric point-amyloid formation of α-synuclein extends the generality of the solubility and supersaturation-limited mechanism,Koki Furukawa,Cesar Aguirre,Masatomo So,Kenji Sasahara,Yohei Miyanoiri,Kazumasa Sakurai,Keiichi Yamaguchi,Kensuke Ikenaka,Hideki Mochizuki,Jozsef Kardos,Yasushi Kawata,Yuji Goto,Current Research in Structural Biology,Elsevier BV,Vol. 2,p. 35-44,2020年,研究論文(学術雑誌)
  • Polyphosphates diminish solubility of a globular protein and thereby promote amyloid aggregation,Kenji Sasahara,Keiichi Yamaguchi,Masatomo So,Yuji Goto,Journal of Biological Chemistry,Elsevier BV,Vol. 294,No. 42,p. 15318-15329,2019年10月,研究論文(学術雑誌)
  • Heating during agitation of β2-microglobulin reveals that supersaturation breakdown is required for amyloid fibril formation at neutral pH,Masahiro Noji,Kenji Sasahara,Keiichi Yamaguchi,Masatomo So,Kazumasa Sakurai,József Kardos,Hironobu Naiki,Yuji Goto,Journal of Biological Chemistry,Elsevier BV,Vol. 294,No. 43,p. 15826-15835,2019年10月,研究論文(学術雑誌)
  • Possible mechanisms of polyphosphate-induced amyloid fibril formation of β2-microglobulin,Chun-ming Zhang,Keiichi Yamaguchi,Masatomo So,Kenji Sasahara,Toru Ito,Suguru Yamamoto,Ichiei Narita,József Kardos,Hironobu Naiki,Yuji Goto,Proceedings of the National Academy of Sciences,Proceedings of the National Academy of Sciences,Vol. 116,No. 26,p. 12833-12838,2019年06月25日,研究論文(学術雑誌)
  • A DISC1 point mutation promotes oligomerization and impairs information processing in a mouse model of schizophrenia,Kyosuke Kakuda,Ayumi Niwa,Ryo Honda,Kei-ichi Yamaguchi,Hiroyuki Tomita,Md Nojebuzzaman,Akira Hara,Yuji Goto,Masatake Osawa,Kazuo Kuwata,The Journal of Biochemistry,Oxford University Press (OUP),Vol. 165,No. 4,p. 369-378,2019年04月01日,研究論文(学術雑誌)
  • A designer molecular chaperone against transmissible spongiform encephalopathy slows disease progression in mice and macaques,Keiichi Yamaguchi,Yuji O. Kamatari,Fumiko Ono,Hiroaki Shibata,Takayuki Fuse,Abdelazim Elsayed Elhelaly,Mayuko Fukuoka,Tsutomu Kimura,Junji Hosokawa-Muto,Takeshi Ishikawa,Minoru Tobiume,Yoshinori Takeuchi,Yutaka Matsuyama,Daisuke Ishibashi,Noriyuki Nishida,Kazuo Kuwata,Nature Biomedical Engineering,Springer Science and Business Media LLC,Vol. 3,No. 3,p. 206-219,2019年03月,研究論文(学術雑誌)
  • A valine-to-lysine substitution at position 210 induces structural conversion of prion protein into a β-sheet rich oligomer,Kyosuke Kakuda,Kei-ichi Yamaguchi,Kazuo Kuwata,Ryo Honda,Biochemical and Biophysical Research Communications,Elsevier BV,Vol. 506,No. 1,p. 81-86,2018年11月,研究論文(学術雑誌)
  • Heat-Induced Aggregation of Hen Ovalbumin Suggests a Key Factor Responsible for Serpin Polymerization,Masahiro Noji,Masatomo So,Keiichi Yamaguchi,Hironobu Hojo,Maki Onda,Yoko Akazawa-Ogawa,Yoshihisa Hagihara,Yuji Goto,Biochemistry,American Chemical Society (ACS),Vol. 57,No. 37,p. 5415-5426,2018年09月18日,研究論文(学術雑誌)
  • Daidzein reductase of Eggerthella sp. YY7918, its octameric subunit structure containing FMN/FAD/4Fe-4S, and its enantioselective production of R-dihydroisoflavones,Yuika Kawada,Tomoko Goshima,Rie Sawamura,Shin-ichiro Yokoyama,Emiko Yanase,Toshio Niwa,Akio Ebihara,Mizuho Inagaki,Keiichi Yamaguchi,Kazuo Kuwata,Yuta Kato,Osamu Sakurada,Tohru Suzuki,Journal of Bioscience and Bioengineering,Elsevier BV,Vol. 126,No. 3,p. 301-309,2018年09月,研究論文(学術雑誌)
  • Poly-L-histidine inhibits prion propagation in a prion-infected cell line,Ryo Honda,Kei-ichi Yamaguchi,Abdelazim Elsayed Elhelaly,Mitsuhiko Fuji,Kazuo Kuwata,Prion,Informa UK Limited,Vol. 12,No. 3-4,p. 226-233,2018年07月04日,研究論文(学術雑誌)
  • Acceleration of nucleation of prion protein during continuous ultrasonication,Kei-ichi Yamaguchi,Ryo P Honda,Abdelazim Elsayed Elhelaly,Kazuo Kuwata,The Journal of Biochemistry,Oxford University Press (OUP),Vol. 163,No. 6,p. 503-513,2018年06月01日,研究論文(学術雑誌)
  • Formation and properties of amyloid fibrils of prion protein,Kei-ichi Yamaguchi,Kazuo Kuwata,Biophysical Reviews,Springer Science and Business Media LLC,Vol. 10,No. 2,p. 517-525,2018年04月,研究論文(学術雑誌)
  • Logical design of an anti-cancer agent targeting the plant homeodomain in Pygopus2,Ferdausi Ali,Keiichi Yamaguchi,Mayuko Fukuoka,Abdelazim Elsayed Elhelaly,Kazuo Kuwata,CANCER SCIENCE,WILEY,Vol. 107,No. 9,p. 1321-1328,2016年09月,研究論文(学術雑誌)
  • Calibration of ultrasonic power and conformational analysis of MoPrP amyloid fibrils,Kei-ichi Yamaguchi,Junji Hosokawa-Muto,Yuji O. Kamatari,Kazuo Kuwata,PRION,TAYLOR & FRANCIS INC,Vol. 10,p. S41-S41,2016年
  • Logical design of anti-prion agents using NAGARA,Biao Ma,Keiichi Yamaguchi,Mayuko Fukuoka,Kazuo Kuwata,BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,ACADEMIC PRESS INC ELSEVIER SCIENCE,Vol. 469,No. 4,p. 930-935,2016年01月,研究論文(学術雑誌)
  • A14 連続超音波照射下におけるプリオン蛋白質の急速凝集反応,山口 圭一,後藤 祐児,桑田 一夫,ソノケミストリー討論会講演論文集,日本ソノケミストリー学会,Vol. 25,p. 97-98,2016年
  • A Native-like Intermediate Serves as a Branching Point between the Folding and Aggregation Pathways of the Mouse Prion Protein,Ryo P. Honda,Ming Xu,Kei-ichi Yamaguchi,Heinrich Roder,Kazuo Kuwata,STRUCTURE,CELL PRESS,Vol. 23,No. 9,p. 1735-1742,2015年09月,研究論文(学術雑誌)
  • Synthesis of double-fluorescent labeled prion protein for FRET analysis,Junji Hosokawa-Muto,Kei-ichi Yamaguchi,Yuji O. Kamatari,Kazuo Kuwata,BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY,TAYLOR & FRANCIS LTD,Vol. 79,No. 11,p. 1802-1809,2015年,研究論文(学術雑誌)
  • Acid-induced Molten Globule State of a Prion Protein CRUCIAL ROLE OF STRAND 1-HELIX 1-STRAND 2 SEGMENT,Ryo P. Honda,Kei-ichi Yamaguchi,Kazuo Kuwata,JOURNAL OF BIOLOGICAL CHEMISTRY,AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC,Vol. 289,No. 44,p. 30355-30363,2014年10月,研究論文(学術雑誌)
  • Characterizing antiprion compounds based on their binding properties to prion proteins: implications as medical chaperones.,Yuji O Kamatari,Yosuke Hayano,Kei-ichi Yamaguchi,Junji Hosokawa-Muto,Kazuo Kuwata,Protein science : a publication of the Protein Society,Vol. 22,No. 1,p. 22-34,2013年01月,研究論文(学術雑誌)
  • Proper calibration of ultrasonic power enabled the quantitative analysis of the ultrasonication-induced amyloid formation process,Kei-ichi Yamaguchi,Tomoharu Matsumoto,Kazuo Kuwata,PROTEIN SCIENCE,WILEY-BLACKWELL,Vol. 21,No. 1,p. 38-49,2012年01月,研究論文(学術雑誌)
  • Structure, Formation and Propagation of Amyloid Fibrils,Yuji Goto,Hisashi Yagi,Keiichi Yamaguchi,Eri Chatani,Tadato Ban,CURRENT PHARMACEUTICAL DESIGN,BENTHAM SCIENCE PUBL LTD,Vol. 14,No. 30,p. 3205-3218,2008年10月
  • 1P-087 β2ミクログロブリンのフラグメントが形成するアミロイド線維構造の構造解析(蛋白質・物性(1),第46回日本生物物理学会年会),Yoshimura Yuichi,Sakurai Kazumasa,Chatana Eri,Kameda Atsushi,Sakai Miyo,Yamaguchi Kei-ichi,Naiki Hironobu,Goto Yuji,生物物理,一般社団法人 日本生物物理学会,Vol. 48,2008年
  • Dimethylsulfoxide-quenched hydrogen/deuterium exchange method to study amyloid fibril structure,Masaru Hoshino,Hidenori Katou,Kei-Ichi Yamaguchi,Yuji Goto,BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES,ELSEVIER SCIENCE BV,Vol. 1768,No. 8,p. 1886-1899,2007年08月
  • Flow-induced alignment of amyloid protofilaments revealed by linear dichroism,Rumi Adachi,Kei-ichi Yamaguchi,Hisashi Yagi,Kazumasa Sakurai,Hironobu Naiki,Yuji Goto,JOURNAL OF BIOLOGICAL CHEMISTRY,AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC,Vol. 282,No. 12,p. 8978-8983,2007年03月,研究論文(学術雑誌)
  • Mechanism by which the amyloid-like fibrils of a β<SUB>2</SUB>-microglobulin fragment are induced by fluorine-substituted alcohols,KI.Yamaguchi,H.Naiki,Y.Goto,J Mol Biol,Vol. 363,No. 1,p. 279-288,2006年10月,研究論文(学術雑誌)
  • Direct observation of amyloid fibril growth, propagation, and adaptation,Tadato Ban,Keiichi Yamaguchi,Yuji Goto,ACCOUNTS OF CHEMICAL RESEARCH,AMER CHEMICAL SOC,Vol. 39,No. 9,p. 663-670,2006年09月
  • Seeding-dependent propagation and maturation of amyloid fibril conformation,Kei-Ichi Yamaguchi,Satoshi Takahashi,Tomoji Kawai,Hironobu Naiki,Yuji Goto,Journal of Molecular Biology,Vol. 352,No. 4,p. 952-960,2005年09月30日,研究論文(学術雑誌)
  • Association of thin filaments into thick filaments revealing the structural hierarchy of amyloid fibrils,Takashi Kanno,Keiichi Yamaguchi,Hironobu Naiki,Yuji Goto,Tomoji Kawai,Journal of Structural Biology,Vol. 149,No. 2,p. 213-218,2005年02月,研究論文(学術雑誌)
  • Stereospecific amyloid-like fibril formation by a peptide fragment of β<SUB>2</SUB>-microglobulin,Wadai, H,Yamaguchi, KI,Takahashi, S,Kanno, T,Kawai, T,Naiki, H,Goto, Y,Biochemistry,Vol. 44,No. 1,p. 157-164,2005年01月,研究論文(学術雑誌)
  • β_2ミクログロブリンのアミロイド線維の構造と形成機構,山口 圭一,後藤 祐児,生物物理,一般社団法人日本生物物理学会,Vol. 44,No. 5,p. 212-217,2004年09月25日

MISC

  • Discovery of anti-prion agents using a PyMOL plugin-based logical drug design platform NAGARA,Biao Ma,Keiichi Yamaguchi,Mayuko Fukuoka,Kazuo Kuwata,PRION,TAYLOR & FRANCIS INC,Vol. 10,p. S46-S47,2016年,研究発表ペーパー・要旨(国際会議)