Supersaturation, a critical factor underlying proteostasis of amyloid fibril formation.

Yuji Goto, Kichitaro Nakajima, Suguru Yamamoto, Keiichi Yamaguchi

Journal of molecular biology　p. 168475-168475　2024/02/02　Research paper (scientific journal)

Ultrastiff Amyloid-Fibril Network of α-Synuclein Formed by Surface Seeding Reaction Confirmed by Multichannel Electrodeless Quartz-Crystal-Microbalance Biosensor

Lianjie Zhou, Touko Hajiri, Kichitaro Nakajima, César Aguirre, Kensuke Ikenaka, Hideki Mochizuki, Keiichi Yamaguchi, Yuji Goto, Hirotsugu Ogi

ACS Sensors　2023/06/26　Research paper (scientific journal)

Phosphatidylinositol-3,4,5-trisphosphate interacts with alpha-synuclein and initiates its aggregation and formation of Parkinson's disease-related fibril polymorphism.

Chi-Jing Choong, César Aguirre, Keita Kakuda, Goichi Beck, Hiroki Nakanishi, Yasuyoshi Kimura, Shuichi Shimma, Kei Nabekura, Makoto Hideshima, Junko Doi, Keiichi Yamaguchi, Kichitaro Nakajima, Tomoya Wadayama, Hideki Hayakawa, Kousuke Baba, Kotaro Ogawa, Toshihide Takeuchi, Shaymaa Mohamed Mohamed Badawy, Shigeo Murayama, Seiichi Nagano, Yuji Goto, Yohei Miyanoiri, Yoshitaka Nagai, Hideki Mochizuki, Kensuke Ikenaka

Acta neuropathologica　Vol. 145　No. 5　p. 573-595　2023/03/20　Research paper (scientific journal)

Mechanisms of polyphosphate-induced amyloid fibril formation triggered by breakdown of supersaturation

Keiichi Yamaguchi, Kichitaro Nakajima, Yuji Goto

Biophysics and Physicobiology　Vol. 20　No. 1　p. n/a-n/a　2023　Research paper (scientific journal)

The residual structure of acid‐denatured β ₂ ‐microglobulin is relevant to an ordered fibril morphology

Ryosuke Tomiyama, Masatomo So, Keiichi Yamaguchi, Yohei Miyanoiri, Kazumasa Sakurai

Protein Science　Vol. 32　No. 1　2022/11　Research paper (scientific journal)

Supersaturation-Dependent Formation of Amyloid Fibrils

Yuji Goto, Masahiro Noji, Kichitaro Nakajima, Keiichi Yamaguchi

Molecules　Vol. 27　No. 14　p. 4588-4588　2022/07/19　Research paper (scientific journal)

Conformational change in the monomeric alpha-synuclein imparts fibril polymorphs

Cesar Aguirre, Kensuke Ikenaka, Masatomo So, Takahiro Maruno, Keiichi Yamaguchi, Kichitaro Nakajima, Chi-Jing Choong, Kei Nabekura, Goichi Beck, Kentaro Tomii, Yu Yamamori, Junko Doi, Tomoyasu Matsubara, Maho Morishima, Keita Kakuda, Makoto Hideshima, Yasuyoshi Kimura, Seiichi Nagano, Kousuke Baba, Shigeo Murayama, Hirotsugu Ogi, Yoshitaka Nagai, Yasushi Kawata, Susumu Uchiyama, Yohei Miyanoiri, Yuji Goto, Hideki Mochizuki

bioRxiv　2022/02/10　Research paper (scientific journal)

Macromolecular crowding and supersaturation protect hemodialysis patients from the onset of dialysis-related amyloidosis

Kichitaro Nakajima, Keiichi Yamaguchi, Masahiro Noji, César Aguirre, Kensuke Ikenaka, Hideki Mochizuki, Lianjie Zhou, Hirotsugu Ogi, Toru Ito, Ichiei Narita, Fumitake Gejyo, Hironobu Naiki, Suguru Yamamoto, Yuji Goto

2022/02/04

Development of HANABI, an ultrasonication-forced amyloid fibril inducer

Yuji Goto, Kichitaro Nakajima, Keiichi Yamaguchi, Masatomo So, Kensuke Ikenaka, Hideki Mochizuki, Hirotsugu Ogi

Neurochemistry International　Vol. 153　p. 105270-105270　2022/02　Research paper (scientific journal)

Two-step screening method to identify α-synuclein aggregation inhibitors for Parkinson's disease.

Makoto Hideshima, Yasuyoshi Kimura, César Aguirre, Keita Kakuda, Toshihide Takeuchi, Chi-Jing Choong, Junko Doi, Kei Nabekura, Keiichi Yamaguchi, Kichitaro Nakajima, Kousuke Baba, Seiichi Nagano, Yuji Goto, Yoshitaka Nagai, Hideki Mochizuki, Kensuke Ikenaka

Scientific reports　Vol. 12　No. 1　p. 351-351　2022/01/10　Research paper (scientific journal)

Acceleration of amyloid fibril formation by multichannel sonochemical reactor

Kentaro Noi, Kichitaro Nakajima, Keiichi Yamaguchi, Masatomo So, Kensuke Ikenaka, Hideki Mochizuki, Yuji Goto, Hirotsugu OGI

Japanese Journal of Applied Physics　2021/12/08　Research paper (scientific journal)

Breakdown of supersaturation barrier links protein folding to amyloid formation

Masahiro Noji, Tatsushi Samejima, Keiichi Yamaguchi, Masatomo So, Keisuke Yuzu, Eri Chatani, Yoko Akazawa-Ogawa, Yoshihisa Hagihara, Yasushi Kawata, Kensuke Ikenaka, Hideki Mochizuki, József Kardos, Daniel E. Otzen, Vittorio Bellotti, Johannes Buchner, Yuji Goto

Communications Biology　Vol. 4　No. 1　2021/12　Research paper (scientific journal)

Strong acids induce amyloid fibril formation of β2-microglobulin via an anion-binding mechanism

Keiichi Yamaguchi, Kenshiro Hasuo, Masatomo So, Kensuke Ikenaka, Hideki Mochizuki, Yuji Goto

Journal of Biological Chemistry　Vol. 297　No. 5　p. 101286-101286　2021/11　Research paper (scientific journal)

1Pa4-5 Accelerating amyloid fibril formation by multi-channel ultrasonic chemical reactor

Noi Kentaro, Nakajima Kichitaro, Yamaguchi Keiichi, So Masatomo, Ikenaka Kensuke, Mochizuki Hideki, Goto Yuji, Ogi Hirotugu

Proceedings of Symposium on Ultrasonic Electronics　Vol. 42　2021/10/25

Half-Time Heat Map Reveals Ultrasonic Effects on Morphology and Kinetics of Amyloidogenic Aggregation Reaction

Kichitaro Nakajima, Hajime Toda, Keiichi Yamaguchi, Masatomo So, Kensuke Ikenaka, Hideki Mochizuki, Yuji Goto, Hirotsugu Ogi

ACS Chemical Neuroscience　Vol. 12　No. 18　p. 3456-3466　2021/09/15　Research paper (scientific journal)

Polyphenol‐solubility alters amyloid fibril formation of α‐synuclein

Masatomo So, Yuto Kimura, Keiichi Yamaguchi, Toshihiko Sugiki, Toshimichi Fujiwara, Cesar Aguirre, Kensuke Ikenaka, Hideki Mochizuki, Yasushi Kawata, Yuji Goto

Protein Science　Vol. 30　No. 8　p. 1701-1713　2021/08　Research paper (scientific journal)

pHによるウレミックトキシンの蛋白結合能の変化

山本 卓, 山口 圭一, 土門 美緒, 伊藤 徹, 後藤 眞, 後藤 祐児, 成田 一衛

日本腎臓学会誌　Vol. 63　No. 4　p. 481-481　2021/06

Optimized sonoreactor for accelerative amyloid-fibril assays through enhancement of primary nucleation and fragmentation

Kichitaro Nakajima, Kentaro Noi, Keiichi Yamaguchi, Masatomo So, Kensuke Ikenaka, Hideki Mochizuki, Hirotsugu Ogi, Yuji Goto

Ultrasonics Sonochemistry　Vol. 73　p. 105508-105508　2021/05　Research paper (scientific journal)

pH-Dependent Protein Binding Properties of Uremic Toxins In Vitro

Suguru Yamamoto, Kenichi Sasahara, Mio Domon, Keiichi Yamaguchi, Toru Ito, Shin Goto, Yuji Goto, Ichiei Narita

Toxins　Vol. 13　No. 2　p. 116-116　2021/02/04　Research paper (scientific journal)

Polyphosphates induce amyloid fibril formation of α-synuclein in concentration-dependent distinct manners

Keiichi Yamaguchi, Masatomo So, César Aguirre, Kensuke Ikenaka, Hideki Mochizuki, Yasushi Kawata, Yuji Goto

Journal of Biological Chemistry　Vol. 296　p. 100510-100510　2021/01　Research paper (scientific journal)

Amyloid Formation of α-Synuclein Based on the Solubility- and Supersaturation-Dependent Mechanism

Maya Sawada, Keiichi Yamaguchi, Miki Hirano, Masahiro Noji, Masatomo So, Daniel Otzen, Yasushi Kawata, Yuji Goto

Langmuir　Vol. 36　No. 17　p. 4671-4681　2020/05/05　Research paper (scientific journal)

Inorganic polyphosphate potentiates lipopolysaccharide-induced macrophage inflammatory response

Toru Ito, Suguru Yamamoto, Keiichi Yamaguchi, Mami Sato, Yoshikatsu Kaneko, Shin Goto, Yuji Goto, Ichiei Narita

Journal of Biological Chemistry　Vol. 295　No. 12　p. 4014-4023　2020/03　Research paper (scientific journal)

Isoelectric point-amyloid formation of α-synuclein extends the generality of the solubility and supersaturation-limited mechanism

Koki Furukawa, Cesar Aguirre, Masatomo So, Kenji Sasahara, Yohei Miyanoiri, Kazumasa Sakurai, Keiichi Yamaguchi, Kensuke Ikenaka, Hideki Mochizuki, Jozsef Kardos, Yasushi Kawata, Yuji Goto

Current Research in Structural Biology　Vol. 2　p. 35-44　2020　Research paper (scientific journal)

Polyphosphates diminish solubility of a globular protein and thereby promote amyloid aggregation

Kenji Sasahara, Keiichi Yamaguchi, Masatomo So, Yuji Goto

Journal of Biological Chemistry　Vol. 294　No. 42　p. 15318-15329　2019/10　Research paper (scientific journal)

Heating during agitation of β2-microglobulin reveals that supersaturation breakdown is required for amyloid fibril formation at neutral pH

Masahiro Noji, Kenji Sasahara, Keiichi Yamaguchi, Masatomo So, Kazumasa Sakurai, József Kardos, Hironobu Naiki, Yuji Goto

Journal of Biological Chemistry　Vol. 294　No. 43　p. 15826-15835　2019/10　Research paper (scientific journal)

Possible mechanisms of polyphosphate-induced amyloid fibril formation of β2-microglobulin

Chun-ming Zhang, Keiichi Yamaguchi, Masatomo So, Kenji Sasahara, Toru Ito, Suguru Yamamoto, Ichiei Narita, József Kardos, Hironobu Naiki, Yuji Goto

Proceedings of the National Academy of Sciences　Vol. 116　No. 26　p. 12833-12838　2019/06/25　Research paper (scientific journal)

A DISC1 point mutation promotes oligomerization and impairs information processing in a mouse model of schizophrenia

Kyosuke Kakuda, Ayumi Niwa, Ryo Honda, Kei-ichi Yamaguchi, Hiroyuki Tomita, Md Nojebuzzaman, Akira Hara, Yuji Goto, Masatake Osawa, Kazuo Kuwata

The Journal of Biochemistry　Vol. 165　No. 4　p. 369-378　2019/04/01　Research paper (scientific journal)

A designer molecular chaperone against transmissible spongiform encephalopathy slows disease progression in mice and macaques

Keiichi Yamaguchi, Yuji O. Kamatari, Fumiko Ono, Hiroaki Shibata, Takayuki Fuse, Abdelazim Elsayed Elhelaly, Mayuko Fukuoka, Tsutomu Kimura, Junji Hosokawa-Muto, Takeshi Ishikawa, Minoru Tobiume, Yoshinori Takeuchi, Yutaka Matsuyama, Daisuke Ishibashi, Noriyuki Nishida, Kazuo Kuwata

Nature Biomedical Engineering　Vol. 3　No. 3　p. 206-219　2019/03　Research paper (scientific journal)

A valine-to-lysine substitution at position 210 induces structural conversion of prion protein into a β-sheet rich oligomer

Kyosuke Kakuda, Kei-ichi Yamaguchi, Kazuo Kuwata, Ryo Honda

Biochemical and Biophysical Research Communications　Vol. 506　No. 1　p. 81-86　2018/11　Research paper (scientific journal)

Heat-Induced Aggregation of Hen Ovalbumin Suggests a Key Factor Responsible for Serpin Polymerization

Masahiro Noji, Masatomo So, Keiichi Yamaguchi, Hironobu Hojo, Maki Onda, Yoko Akazawa-Ogawa, Yoshihisa Hagihara, Yuji Goto

Biochemistry　Vol. 57　No. 37　p. 5415-5426　2018/09/18　Research paper (scientific journal)

Daidzein reductase of Eggerthella sp. YY7918, its octameric subunit structure containing FMN/FAD/4Fe-4S, and its enantioselective production of R-dihydroisoflavones

Yuika Kawada, Tomoko Goshima, Rie Sawamura, Shin-ichiro Yokoyama, Emiko Yanase, Toshio Niwa, Akio Ebihara, Mizuho Inagaki, Keiichi Yamaguchi, Kazuo Kuwata, Yuta Kato, Osamu Sakurada, Tohru Suzuki

Journal of Bioscience and Bioengineering　Vol. 126　No. 3　p. 301-309　2018/09　Research paper (scientific journal)

Poly-L-histidine inhibits prion propagation in a prion-infected cell line

Ryo Honda, Kei-ichi Yamaguchi, Abdelazim Elsayed Elhelaly, Mitsuhiko Fuji, Kazuo Kuwata

Prion　Vol. 12　No. 3-4　p. 226-233　2018/07/04　Research paper (scientific journal)

Acceleration of nucleation of prion protein during continuous ultrasonication

Kei-ichi Yamaguchi, Ryo P Honda, Abdelazim Elsayed Elhelaly, Kazuo Kuwata

The Journal of Biochemistry　Vol. 163　No. 6　p. 503-513　2018/06/01　Research paper (scientific journal)

Formation and properties of amyloid fibrils of prion protein

Kei-ichi Yamaguchi, Kazuo Kuwata

Biophysical Reviews　Vol. 10　No. 2　p. 517-525　2018/04　Research paper (scientific journal)

Logical design of an anti-cancer agent targeting the plant homeodomain in Pygopus2

Ferdausi Ali, Keiichi Yamaguchi, Mayuko Fukuoka, Abdelazim Elsayed Elhelaly, Kazuo Kuwata

CANCER SCIENCE　Vol. 107　No. 9　p. 1321-1328　2016/09　Research paper (scientific journal)

Calibration of ultrasonic power and conformational analysis of MoPrP amyloid fibrils

Kei-ichi Yamaguchi, Junji Hosokawa-Muto, Yuji O. Kamatari, Kazuo Kuwata

PRION　Vol. 10　p. S41-S41　2016

Logical design of anti-prion agents using NAGARA

Biao Ma, Keiichi Yamaguchi, Mayuko Fukuoka, Kazuo Kuwata

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 469　No. 4　p. 930-935　2016/01　Research paper (scientific journal)

A14 Rapid aggregate reaction of prion protein under the continuous ultrasonication

Yamaguchi Keiichi, Goto Yuji, Kuwata Kazuo

Proceedings of the Annual Meeting of the Japan Society of Sonochemistry　Vol. 25　p. 97-98　2016

A Native-like Intermediate Serves as a Branching Point between the Folding and Aggregation Pathways of the Mouse Prion Protein

Ryo P. Honda, Ming Xu, Kei-ichi Yamaguchi, Heinrich Roder, Kazuo Kuwata

STRUCTURE　Vol. 23　No. 9　p. 1735-1742　2015/09　Research paper (scientific journal)

Synthesis of double-fluorescent labeled prion protein for FRET analysis

Junji Hosokawa-Muto, Kei-ichi Yamaguchi, Yuji O. Kamatari, Kazuo Kuwata

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY　Vol. 79　No. 11　p. 1802-1809　2015　Research paper (scientific journal)

Acid-induced Molten Globule State of a Prion Protein CRUCIAL ROLE OF STRAND 1-HELIX 1-STRAND 2 SEGMENT

Ryo P. Honda, Kei-ichi Yamaguchi, Kazuo Kuwata

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 289　No. 44　p. 30355-30363　2014/10　Research paper (scientific journal)

Nearly reversible conformational change of amyloid fibrils as revealed by ph-jump experiments

Kei-Ichi Yamaguchi, Yuji O. Kamatari, Mayuko Fukuoka, Reiji Miyaji, Kazuo Kuwata

Biochemistry　Vol. 52　No. 39　p. 6797-6806　2013/10/01　Research paper (scientific journal)

Characterizing antiprion compounds based on their binding properties to prion proteins: implications as medical chaperones.

Yuji O Kamatari, Yosuke Hayano, Kei-ichi Yamaguchi, Junji Hosokawa-Muto, Kazuo Kuwata

Protein science : a publication of the Protein Society　Vol. 22　No. 1　p. 22-34　2013/01　Research paper (scientific journal)

Proper calibration of ultrasonic power enabled the quantitative analysis of the ultrasonication-induced amyloid formation process

Kei-ichi Yamaguchi, Tomoharu Matsumoto, Kazuo Kuwata

PROTEIN SCIENCE　Vol. 21　No. 1　p. 38-49　2012/01　Research paper (scientific journal)

3P078 Classification of anti-prion compounds based on the binding properties of prion proteins(Protein: Property,The 48th Annual Meeting of the Biophysical Society of Japan)

Kamatari Yuji, Hayano Yosuke, Yamaguchi Kei-ichi, Hosokawa-Muto Junji, Kuwata Kazuo

Seibutsu Butsuri　Vol. 50　No. 2　2010

Structure, Formation and Propagation of Amyloid Fibrils

Yuji Goto, Hisashi Yagi, Keiichi Yamaguchi, Eri Chatani, Tadato Ban

CURRENT PHARMACEUTICAL DESIGN　Vol. 14　No. 30　p. 3205-3218　2008/10

1P-087 Structural analysis of the amyloid fibril formed by the fragment of β2-microglobulin(The 46th Annual Meeting of the Biophysical Society of Japan)

Yoshimura Yuichi, Sakurai Kazumasa, Chatana Eri, Kameda Atsushi, Sakai Miyo, Yamaguchi Kei-ichi, Naiki Hironobu, Goto Yuji

Seibutsu Butsuri　Vol. 48　2008

Dimethylsulfoxide-quenched hydrogen/deuterium exchange method to study amyloid fibril structure

Masaru Hoshino, Hidenori Katou, Kei-Ichi Yamaguchi, Yuji Goto

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES　Vol. 1768　No. 8　p. 1886-1899　2007/08

Flow-induced alignment of amyloid protofilaments revealed by linear dichroism

Rumi Adachi, Kei-ichi Yamaguchi, Hisashi Yagi, Kazumasa Sakurai, Hironobu Naiki, Yuji Goto

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 282　No. 12　p. 8978-8983　2007/03　Research paper (scientific journal)

Mechanism by which the amyloid-like fibrils of a beta(2)-microglobulin fragment are induced by fluorine-substituted alcohols

Kei-ichi Yamaguchi, Hironobu Naiki, Yuji Goto

JOURNAL OF MOLECULAR BIOLOGY　Vol. 363　No. 1　p. 279-288　2006/10　Research paper (scientific journal)

Direct observation of amyloid fibril growth, propagation, and adaptation

Tadato Ban, Keiichi Yamaguchi, Yuji Goto

ACCOUNTS OF CHEMICAL RESEARCH　Vol. 39　No. 9　p. 663-670　2006/09

Seeding-dependent propagation and maturation of amyloid fibril conformation

Kei-Ichi Yamaguchi, Satoshi Takahashi, Tomoji Kawai, Hironobu Naiki, Yuji Goto

Journal of Molecular Biology　Vol. 352　No. 4　p. 952-960　2005/09/30　Research paper (scientific journal)

Metal ion-dependent effects of clioquinol on the fibril growth of an amyloid beta peptide

B Raman, T Ban, K Yamaguchi, M Sakai, T Kawai, H Naiki, Y Goto

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 280　No. 16　p. 16157-16162　2005/04　Research paper (scientific journal)

Association of thin filaments into thick filaments revealing the structural hierarchy of amyloid fibrils

Takashi Kanno, Keiichi Yamaguchi, Hironobu Naiki, Yuji Goto, Tomoji Kawai

Journal of Structural Biology　Vol. 149　No. 2　p. 213-218　2005/02　Research paper (scientific journal)

Stereospecific amyloid-like fibril formation by a peptide fragment of beta(2)-microglobulin

H Wadai, K Yamaguchi, S Takahashi, T Kanno, T Kawai, H Naiki, Y Goto

BIOCHEMISTRY　Vol. 44　No. 1　p. 157-164　2005/01　Research paper (scientific journal)

Structure and Formation of Amyloid Fibrils of β_2-Microglobulin

YAMAGUCHI Keiichi, GOTO Yuji

Biophysics　Vol. 44　No. 5　p. 212-217　2004/09/25

Core and heterogeneity of beta(2)-microglobulin amyloid fibrils as revealed by H/D exchange

KI Yamaguchi, H Katou, M Hoshino, K Hasegawa, H Naiki, Y Goto

JOURNAL OF MOLECULAR BIOLOGY　Vol. 338　No. 3　p. 559-571　2004/04　Research paper (scientific journal)

Effect of Enantiomeric Fragment for Amyloid Fibril Formation

Wadai H., Yamaguchi K., Kanno T., Nakamura T., T. Tomoji, Hasagawa K., Naiki H., Goto Y.

Seibutsu Butsuri　Vol. 43　2003