-
Modulation of Ca2+ oscillation following ischemia and nicotinic acetylcholine receptors in primary cortical neurons by high-throughput analysis.
Tsutomu Sasaki, Sunao Hisada, Hideaki Kanki, Kazuto Nunomura, Bangzhong Lin, Kumiko Nishiyama, Tomohito Kawano, Shigenobu Matsumura, Hideki Mochizuki
Scientific reports Vol. 14 No. 1 p. 27667-27667 2024年11月12日 研究論文（学術雑誌）
-
Development of a high-throughput screening system targeting the protein-protein interactions between PRL and CNNM.
Yosuke Funato, Mai Mimura, Kazuto Nunomura, Bangzhong Lin, Shintarou Fujii, Junichi Haruta, Hiroaki Miki
Scientific reports Vol. 14 No. 1 p. 25432-25432 2024年10月25日 研究論文（学術雑誌）
-
Anti-Schistosomal activity and ADMET properties of 1,2,5-oxadiazinane-containing compound synthesized by visible-light photoredox catalysis.
Kennosuke Itoh, Hiroki Nakahara, Atsushi Takashino, Aya Hara, Akiho Katsuno, Yuriko Abe, Takaaki Mizuguchi, Fumika Karaki, Shigeto Hirayama, Kenichiro Nagai, Reiko Seki, Noriko Sato, Kazuki Okuyama, Masashi Hashimoto, Ken Tokunaga, Hitoshi Ishida, Fusako Mikami, Kofi Dadzie Kwofie, Hayato Kawada, Bangzhong Lin, Kazuto Nunomura, Toshio Kanai, Takeshi Hatta, Naotoshi Tsuji, Junichi Haruta, Hideaki Fujii
RSC medicinal chemistry 2024年9月26日 研究論文（学術雑誌）
-
Bayesian approach enabled objective comparison of multiple human iPSC-derived Cardiomyocytes' Proarrhythmia sensitivities.
Tetsuro Wakatsuki, Neil Daily, Sunao Hisada, Kazuto Nunomura, Bangzhong Lin, Ko Zushida, Yayoi Honda, Mahoko Asyama, Kiyoshi Takasuna
Journal of pharmacological and toxicological methods p. 107531-107531 2024年6月7日 研究論文（学術雑誌）
-
Design and synthesis of 4-acetoxypentanamide derivatives of spliceostatin A and their biological evaluation towards prostate cancer treatment.
Satoru Hirabayashi, Yuko Tsuyuguchi, Yue Li, Noriko Ohta, Yusuke Yoshikawa, Bangzhong Lin, Megumi Fumimoto, Kazuto Nunomura, Takeyuki Suzuki, Junichi Haruta, Keisuke Nimura, Mitsuhiro Arisawa
Bioorganic & medicinal chemistry letters p. 129333-129333 2023年5月17日 研究論文（学術雑誌）
-
Celastrol suppresses humoral immune responses and autoimmunity by targeting the COMMD3/8 complex.
Taiichiro Shirai, Akiko Nakai, Emiko Ando, Jun Fujimoto, Sarah Leach, Takao Arimori, Daisuke Higo, Floris J van Eerden, Janyerkye Tulyeu, Yu-Chen Liu, Daisuke Okuzaki, Masanori A Murayama, Haruhiko Miyata, Kazuto Nunomura, Bangzhong Lin, Akiyoshi Tani, Atsushi Kumanogoh, Masahito Ikawa, James B Wing, Daron M Standley, Junichi Takagi, Kazuhiro Suzuki
Science immunology Vol. 8 No. 81 2023年3月31日 研究論文（学術雑誌）
-
Design and Synthesis of Ether Derivatives of Spliceostatin A and their Biological Evaluation towards Prostate Cancer Treatment
Satoru Hirabayashi, Yue Li, Noriko Ohta, Airi Ishibashi, Yue Li, Yusuke Yoshikawa, Bangzhong Lin, Megumi Fumimoto, Tsunayoshi Takehara, Kazuto Nunomura, Takeyuki Suzuki, Junichi Haruta, Keisuke Nimura, Mitsuhiro Arisawa
Tetrahedron Letters Vol. 114 p. 154288-154288 2022年12月 研究論文（学術雑誌）
出版者・発行元：Elsevier BV
-
Design, Synthesis, and Monoamine Oxidase B Selective Inhibitory Activity of N-Arylated Heliamine Analogues
Makito Yamada, Yu Hirose, Bangzhong Lin, Megumi Fumimoto, Kazuto Nunomura, Sirimangkalakitti Natchanun, Naoyuki Takahashi, Yuuta Ohki, Makoto Sako, Kenichi Murai, Kazuo Harada, Masayoshi Arai, Sayo Suzuki, Tomonori Nakamura, Junichi Haruta, Mitsuhiro Arisawa
ACS Medicinal Chemistry Letters 2022年8月22日 研究論文（学術雑誌）
出版者・発行元：American Chemical Society (ACS)
-
Discovery of Benzylpiperazine Derivatives as CNS-Penetrant and Selective Histone Deacetylase 6 Inhibitors
Kosuke Hashimoto, Soichiro Ide, Mayumi Arata, Akiko Nakata, Akihiro Ito, Takashi K. Ito, Norio Kudo, Bangzhong Lin, Kazuto Nunomura, Keiko Tsuganezawa, Minoru Yoshida, Yasuo Nagaoka, Takaaki Sumiyoshi
ACS Medicinal Chemistry Letters Vol. 13 No. 7 p. 1077-1082 2022年6月28日 研究論文（学術雑誌）
出版者・発行元：American Chemical Society (ACS)
-
The K-Ras(G12D)-inhibitory peptide KS-58 suppresses growth of murine CT26 colorectal cancer cell-derived tumors
Kotaro Sakamoto, Bangzhong Lin, Kazuto Nunomura, Takeshi Izawa, Shinsaku Nakagawa
Scientific Reports Vol. 12 No. 1 p. 8121-8121 2022年5月17日 研究論文（学術雑誌）
出版者・発行元：Springer Science and Business Media LLC
-
Physicochemical and Biochemical Evaluation of Amorphous Solid Dispersion of Naringenin Prepared Using Hot-Melt Extrusion
Kenji Ishimoto, Yukiko Shimada, Akane Ohno, Shuichi Otani, Yukio Ago, Soya Maeda, Bangzhong Lin, Kazuto Nunomura, Nobumasa Hino, Masayuki Suzuki, Shinsaku Nakagawa
Frontiers in Nutrition Vol. 9 p. 850103-850103 2022年4月27日 研究論文（学術雑誌）
出版者・発行元：Frontiers Media SA
-
Design and synthesis of pyrido[2,3-d]pyrimidine derivatives for a novel PAC1 receptor antagonist
Ichiro Takasaki, Ai Watanabe, Takuya Okada, Daisuke Kanayama, Ryota Nagashima, Miyu Shudo, Ayaka Shimodaira, Kazuto Nunomura, Bangzhong Lin, Yurie Watanabe, Hiroaki Gouda, Atsuro Miyata, Takashi Kurihara, Naoki Toyooka
European Journal of Medicinal Chemistry Vol. 231 p. 114160-114160 2022年3月 研究論文（学術雑誌）
出版者・発行元：Elsevier BV
-
Gosha-jinki-Gan (GJG) shows anti-aging effects through suppression of TNF-α production by Chikusetsusaponin V
Keisuke Hagihara, Kazuto Nunomura, Bangzhong Lin, Megumi Fumimoto, Junko Watanabe, Yasuharu Mizuhara
Gene Vol. 815 p. 146178-146178 2022年3月 研究論文（学術雑誌）
出版者・発行元：Elsevier BV
-
A novel RyR1-selective inhibitor prevents and rescues sudden death in mouse models of malignant hyperthermia and heat stroke
Toshiko Yamazawa, Takuya Kobayashi, Nagomi Kurebayashi, Masato Konishi, Satoru Noguchi, Takayoshi Inoue, Yukiko U. Inoue, Ichizo Nishino, Shuichi Mori, Hiroto Iinuma, Noriaki Manaka, Hiroyuki Kagechika, Arkady Uryash, Jose Adams, Jose R. Lopez, Xiaochen Liu, Christine Diggle, Paul D. Allen, Sho Kakizawa, Keigo Ikeda, Bangzhong Lin, Yui Ikemi, Kazuto Nunomura, Shinsaku Nakagawa, Takashi Sakurai, Takashi Murayama
Nature Communications Vol. 12 No. 1 2021年12月 研究論文（学術雑誌）
-
Microtubule inhibitors identified through non-biased screening enhance DNA transfection efficiency by delaying p62-dependent ubiquitin recruitment
Megumi Tsuchiya, Hidesato Ogawa, Kento Watanabe, Takako Koujin, Chie Mori, Kazuto Nunomura, Bangzhong Lin, Akiyoshi Tani, Yasushi Hiraoka, Tokuko Haraguchi
Genes to cells : devoted to molecular & cellular mechanisms Vol. 26 No. 9 p. 739-751 2021年9月 研究論文（学術雑誌）
-
Design, synthesis, physical properties and indoleamine 2, 3-dioxygenase 1 inhibitory activity of substitued indole derivatives with N-H, N-metohymethyl, or N-mehylthiomethyl groups toward fragment-based drug discovery
Kenta Hayami, Yuichi Kuboki, Katsumi Ohta, Bangzhong Lin, Megumi Fumimoto, Kazuto Nunomura, Jun Ichi Haruta, Kenichi Murai, Hiromichi Fujioka, Akira Asai, Mitsuhiro Arisawa
Heterocycles Vol. 103 No. 1 p. 511-525 2021年 研究論文（学術雑誌）
-
Structural development of 1H-pyrazolo-[3,4-b]pyridine-4-carboxylic acid derivatives as human peroxisome proliferator-activated receptor alpha (PPARα)-selective agonists
Miyachi H, Yuzuriha T, Tabata R, Fukuda S, Nunomura K, Lin B, Kobayashi T, Ishimoto K, Doi T, Tachibana K
Bioorganic & medicinal chemistry letters Vol. 29 No. 16 p. 2124-2128 2019年8月 研究論文（学術雑誌）
-
Discovery of peroxisome proliferator-activated receptor α (PPARα) activators with a ligand-screening system using a human PPARα-expressing cell line
Tachibana K, Yuzuriha T, Tabata R, Fukuda S, Maegawa T, Takahashi R, Tanimoto K, Tsujino H, Nunomura K, Lin B, Matsuura Y, Tanaka T, Hamakubo T, Sakai J, Kodama T, Kobayashi T, Ishimoto K, Miyachi H, Doi T
Journal of biological chemistry Vol. 293 No. 26 p. 10333-10343 2018年6月 研究論文（学術雑誌）
-
Semisynthesis and biological evaluation of a cotylenin A mimic derived from fusicoccin A
Takatsugu Inoue, Yusuke Higuchi, Toru Yoneyama, Bangzhong Lin, Kazuto Nunomura, Yoshio Honma, Nobuo Kato
Bioorganic & medicinal chemistry letters Vol. 28 No. 4 p. 646-650 2018年2月15日 研究論文（学術雑誌）
-
Unbiased compound screening with a reporter gene assay highlights the role of p13 in the cardiac cellular stress response
Inoue N, Hirouchi T, Kasai A, Higashi S, Hiraki N, Tanaka S, Nakazawa T, Nunomura K, Lin B, Omori A, Hayata-Takano A, Kim YJ, Doi T, Baba A, Hashimoto H, Shintani N
Biochemical and biophysical research communications Vol. 495 No. 2 p. 1992-1997 2018年1月 研究論文（学術雑誌）
出版者・発行元：
-
High-throughput Fluorescence Measurements of Membrane Potential and Ca2+ Transients in Human iPSC-Derived Cardiomyocytes for Assessment of Drug-Induced Arrhythmia
Sunao Hisada, Natsumi Kato, Masanori Matsubara, Takuji Kataoka, Fumio Iwase, Bangzhong Lin, Kazuto Nunomura, Yoon-Jeong Kim
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS Vol. 88 p. 187-187 2017年11月
-
Opposing roles for SNAP23 in secretion in exocrine and endocrine pancreatic cells
Kunii M, Ohara-Imaizumi M, Takahashi N, Kobayashi M, Kawakami R, Kondoh Y, Shimizu T, Simizu S, Lin B, Nunomura K, Aoyagi K, Ohno M, Ohmuraya M, Sato T, Yoshimura SI, Sato K, Harada R, Kim YJ, Osada H, Nemoto T, Kasai H, Kitamura T, Nagamatsu S, Harada A
Journal of cell biology Vol. 215 No. 1 p. 121-138 2016年10月 研究論文（学術雑誌）
出版者・発行元：
-
MARCKS-like protein, a membrane protein identified for its expression in developing neural retina, plays a role in regulating retinal cell proliferation
Zhao J, Izumi T, Izumi T, Nunomura K, Nunomura K, Satoh S, Watanabe S
Biochemical Journal Vol. 408 No. 1 p. 51-59 2007年11月 研究論文（学術雑誌）
-
Rb plays a role in survival of Abl-dependent human tumor cells as a downstream effector of Abl tyrosine kinase
Nagano K, Itagaki C, Izumi T, Nunomura K, Soda Y, Tani K, Takahashi N, Takenawa T, Isobe T, Isobe T
Oncogene Vol. 25 No. 4 p. 493-502 2006年1月 研究論文（学術雑誌）
-
Cell surface labeling and mass spectrometry reveal diversity of cell surface markers and signaling molecules expressed in undifferentiated mouse embryonic stem cells
Nunomura K, Nagano K, Itagaki C, Taoka M, Okamura N, Okamura N, Yamauchi Y, Sugano S, Takahashi N, Izumi T, Isobe T, Isobe T
Molecular and Cellular Proteomics Vol. 4 No. 12 p. 1968-1976 2005年12月 研究論文（学術雑誌）
-
Large-scale identification of proteins expressed in mouse embryonic stem cells
Nagano K, Taoka M, Yamauchi Y, Itagaki C, Shinkawa T, Nunomura K, Okamura N, Takahashi N, Takahashi N, Izumi T, Isobe T, Isobe T, Isobe T, Isobe T
Proteomics Vol. 5 No. 5 p. 1346-1361 2005年4月 研究論文（学術雑誌）
-
In vivo cross-linking of nucleosomal histones catalyzed by nuclear transglutaminase in starfish sperm and its induction by egg jelly triggering the acrosome reaction
Nunomura K, Nunomura K, Kawakami S, Kawakami S, Shimizu T, Shimizu T, Hara T, Nakamura K, Terakawa Y, Yamasaki A, Ikegami S, Ikegami S
European Journal of Biochemistry Vol. 270 No. 18 p. 3750-3759 2003年9月 研究論文（学術雑誌）
-
A novel histone heterodimer that appears at a specific stage of embryonic development
Ikegami S, Shimizu T, Hozumi K, Nunomura K, Takao T, Shimonishi Y
FASEB Journal Vol. 11 No. 9 1997年12月 研究論文（学術雑誌）
-
Structure of a covalently cross-linked form of core histones present in the starfish sperm
Shimizu T, Shimizu T, Takao T, Hozumi K, Nunomura K, Ohta S, Shimonishi Y, Ikegami S, Ikegami S
Biochemistry Vol. 36 No. 40 p. 12071-12079 1997年10月 研究論文（学術雑誌）
-
A novel modification of the lysine residue at position 12 of histone H4 in starfish sperm
Nunomura K, Shimizu T, Shimizu T, Hozumi K, Takao T, Takao T, Shimonishi Y, Shimonishi Y, Ikegami S
Bioscience, Biotechnology and Biochemistry Vol. 61 No. 12 p. 2151-2152 1997年1月 研究論文（学術雑誌）
出版者・発行元：社団法人日本農芸化学会
-
A covalently crosslinked histone
Shlmizu T, Hozumi H, Horiike S, Nunomura K, Ikegami S, Takao T, Shimonishi Y
Nature Vol. 380 No. 32 1996年3月 研究論文（学術雑誌）
