Celastrol suppresses humoral immune responses and autoimmunity by targeting the COMMD3/8 complex.

Taiichiro Shirai, Akiko Nakai, Emiko Ando, Jun Fujimoto, Sarah Leach, Takao Arimori, Daisuke Higo, Floris J van Eerden, Janyerkye Tulyeu, Yu-Chen Liu, Daisuke Okuzaki, Masanori A Murayama, Haruhiko Miyata, Kazuto Nunomura, Bangzhong Lin, Akiyoshi Tani, Atsushi Kumanogoh, Masahito Ikawa, James B Wing, Daron M Standley, Junichi Takagi, Kazuhiro Suzuki

Science immunology　Vol. 8　No. 81　2023/03/31　Research paper (scientific journal)

Design and Synthesis of Ether Derivatives of Spliceostatin A and their Biological Evaluation towards Prostate Cancer Treatment

Satoru Hirabayashi, Yue Li, Noriko Ohta, Airi Ishibashi, Yue Li, Yusuke Yoshikawa, Bangzhong Lin, Megumi Fumimoto, Tsunayoshi Takehara, Kazuto Nunomura, Takeyuki Suzuki, Junichi Haruta, Keisuke Nimura, Mitsuhiro Arisawa

Tetrahedron Letters　Vol. 114　p. 154288-154288　2022/12　Research paper (scientific journal)

Design, Synthesis, and Monoamine Oxidase B Selective Inhibitory Activity of N-Arylated Heliamine Analogues

Makito Yamada, Yu Hirose, Bangzhong Lin, Megumi Fumimoto, Kazuto Nunomura, Sirimangkalakitti Natchanun, Naoyuki Takahashi, Yuuta Ohki, Makoto Sako, Kenichi Murai, Kazuo Harada, Masayoshi Arai, Sayo Suzuki, Tomonori Nakamura, Junichi Haruta, Mitsuhiro Arisawa

ACS Medicinal Chemistry Letters　2022/08/22　Research paper (scientific journal)

Discovery of Benzylpiperazine Derivatives as CNS-Penetrant and Selective Histone Deacetylase 6 Inhibitors

Kosuke Hashimoto, Soichiro Ide, Mayumi Arata, Akiko Nakata, Akihiro Ito, Takashi K. Ito, Norio Kudo, Bangzhong Lin, Kazuto Nunomura, Keiko Tsuganezawa, Minoru Yoshida, Yasuo Nagaoka, Takaaki Sumiyoshi

ACS Medicinal Chemistry Letters　Vol. 13　No. 7　p. 1077-1082　2022/06/28　Research paper (scientific journal)

The K-Ras(G12D)-inhibitory peptide KS-58 suppresses growth of murine CT26 colorectal cancer cell-derived tumors

Kotaro Sakamoto, Bangzhong Lin, Kazuto Nunomura, Takeshi Izawa, Shinsaku Nakagawa

Scientific Reports　Vol. 12　No. 1　p. 8121-8121　2022/05/17　Research paper (scientific journal)

Physicochemical and Biochemical Evaluation of Amorphous Solid Dispersion of Naringenin Prepared Using Hot-Melt Extrusion

Kenji Ishimoto, Yukiko Shimada, Akane Ohno, Shuichi Otani, Yukio Ago, Soya Maeda, Bangzhong Lin, Kazuto Nunomura, Nobumasa Hino, Masayuki Suzuki, Shinsaku Nakagawa

Frontiers in Nutrition　Vol. 9　p. 850103-850103　2022/04/27　Research paper (scientific journal)

Design and synthesis of pyrido[2,3-d]pyrimidine derivatives for a novel PAC1 receptor antagonist

Ichiro Takasaki, Ai Watanabe, Takuya Okada, Daisuke Kanayama, Ryota Nagashima, Miyu Shudo, Ayaka Shimodaira, Kazuto Nunomura, Bangzhong Lin, Yurie Watanabe, Hiroaki Gouda, Atsuro Miyata, Takashi Kurihara, Naoki Toyooka

European Journal of Medicinal Chemistry　Vol. 231　p. 114160-114160　2022/03　Research paper (scientific journal)

Gosha-jinki-Gan (GJG) shows anti-aging effects through suppression of TNF-α production by Chikusetsusaponin V

Keisuke Hagihara, Kazuto Nunomura, Bangzhong Lin, Megumi Fumimoto, Junko Watanabe, Yasuharu Mizuhara

Gene　Vol. 815　p. 146178-146178　2022/03　Research paper (scientific journal)

A novel RyR1-selective inhibitor prevents and rescues sudden death in mouse models of malignant hyperthermia and heat stroke

Toshiko Yamazawa, Takuya Kobayashi, Nagomi Kurebayashi, Masato Konishi, Satoru Noguchi, Takayoshi Inoue, Yukiko U. Inoue, Ichizo Nishino, Shuichi Mori, Hiroto Iinuma, Noriaki Manaka, Hiroyuki Kagechika, Arkady Uryash, Jose Adams, Jose R. Lopez, Xiaochen Liu, Christine Diggle, Paul D. Allen, Sho Kakizawa, Keigo Ikeda, Bangzhong Lin, Yui Ikemi, Kazuto Nunomura, Shinsaku Nakagawa, Takashi Sakurai, Takashi Murayama

Nature Communications　Vol. 12　No. 1　2021/12　Research paper (scientific journal)

Microtubule inhibitors identified through non-biased screening enhance DNA transfection efficiency by delaying p62-dependent ubiquitin recruitment

Megumi Tsuchiya, Hidesato Ogawa, Kento Watanabe, Takako Koujin, Chie Mori, Kazuto Nunomura, Bangzhong Lin, Akiyoshi Tani, Yasushi Hiraoka, Tokuko Haraguchi

Genes to cells : devoted to molecular & cellular mechanisms　Vol. 26　No. 9　p. 739-751　2021/09　Research paper (scientific journal)

Design, synthesis, physical properties and indoleamine 2, 3-dioxygenase 1 inhibitory activity of substitued indole derivatives with N-H, N-metohymethyl, or N-mehylthiomethyl groups toward fragment-based drug discovery

Kenta Hayami, Yuichi Kuboki, Katsumi Ohta, Bangzhong Lin, Megumi Fumimoto, Kazuto Nunomura, Jun Ichi Haruta, Kenichi Murai, Hiromichi Fujioka, Akira Asai, Mitsuhiro Arisawa

Heterocycles　Vol. 103　No. 1　p. 511-525　2021　Research paper (scientific journal)

Structural development of 1H-pyrazolo-[3,4-b]pyridine-4-carboxylic acid derivatives as human peroxisome proliferator-activated receptor alpha (PPARα)-selective agonists

Miyachi H, Yuzuriha T, Tabata R, Fukuda S, Nunomura K, Lin B, Kobayashi T, Ishimoto K, Doi T, Tachibana K

Bioorganic & medicinal chemistry letters　Vol. 29　No. 16　p. 2124-2128　2019/08　Research paper (scientific journal)

Discovery of peroxisome proliferator-activated receptor α (PPARα) activators with a ligand-screening system using a human PPARα-expressing cell line

Tachibana K, Yuzuriha T, Tabata R, Fukuda S, Maegawa T, Takahashi R, Tanimoto K, Tsujino H, Nunomura K, Lin B, Matsuura Y, Tanaka T, Hamakubo T, Sakai J, Kodama T, Kobayashi T, Ishimoto K, Miyachi H, Doi T

Journal of biological chemistry　Vol. 293　No. 26　p. 10333-10343　2018/06　Research paper (scientific journal)

Semisynthesis and biological evaluation of a cotylenin A mimic derived from fusicoccin A

Takatsugu Inoue, Yusuke Higuchi, Toru Yoneyama, Bangzhong Lin, Kazuto Nunomura, Yoshio Honma, Nobuo Kato

Bioorganic & medicinal chemistry letters　Vol. 28　No. 4　p. 646-650　2018/02/15　Research paper (scientific journal)

Unbiased compound screening with a reporter gene assay highlights the role of p13 in the cardiac cellular stress response

Inoue N, Hirouchi T, Kasai A, Higashi S, Hiraki N, Tanaka S, Nakazawa T, Nunomura K, Lin B, Omori A, Hayata-Takano A, Kim YJ, Doi T, Baba A, Hashimoto H, Shintani N

Biochemical and biophysical research communications　Vol. 495　No. 2　p. 1992-1997　2018/01　Research paper (scientific journal)

High-throughput Fluorescence Measurements of Membrane Potential and Ca2+ Transients in Human iPSC-Derived Cardiomyocytes for Assessment of Drug-Induced Arrhythmia

Sunao Hisada, Natsumi Kato, Masanori Matsubara, Takuji Kataoka, Fumio Iwase, Bangzhong Lin, Kazuto Nunomura, Yoon-Jeong Kim

JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS　Vol. 88　p. 187-187　2017/11

Opposing roles for SNAP23 in secretion in exocrine and endocrine pancreatic cells

Kunii M, Ohara-Imaizumi M, Takahashi N, Kobayashi M, Kawakami R, Kondoh Y, Shimizu T, Simizu S, Lin B, Nunomura K, Aoyagi K, Ohno M, Ohmuraya M, Sato T, Yoshimura SI, Sato K, Harada R, Kim YJ, Osada H, Nemoto T, Kasai H, Kitamura T, Nagamatsu S, Harada A

Journal of cell biology　Vol. 215　No. 1　p. 121-138　2016/10　Research paper (scientific journal)

MARCKS-like protein, a membrane protein identified for its expression in developing neural retina, plays a role in regulating retinal cell proliferation

Zhao J, Izumi T, Izumi T, Nunomura K, Nunomura K, Satoh S, Watanabe S

Biochemical Journal　Vol. 408　No. 1　p. 51-59　2007/11　Research paper (scientific journal)

Rb plays a role in survival of Abl-dependent human tumor cells as a downstream effector of Abl tyrosine kinase

Nagano K, Itagaki C, Izumi T, Nunomura K, Soda Y, Tani K, Takahashi N, Takenawa T, Isobe T, Isobe T

Oncogene　Vol. 25　No. 4　p. 493-502　2006/01　Research paper (scientific journal)

Cell surface labeling and mass spectrometry reveal diversity of cell surface markers and signaling molecules expressed in undifferentiated mouse embryonic stem cells

Nunomura K, Nagano K, Itagaki C, Taoka M, Okamura N, Okamura N, Yamauchi Y, Sugano S, Takahashi N, Izumi T, Isobe T, Isobe T

Molecular and Cellular Proteomics　Vol. 4　No. 12　p. 1968-1976　2005/12　Research paper (scientific journal)

Large-scale identification of proteins expressed in mouse embryonic stem cells

Nagano K, Taoka M, Yamauchi Y, Itagaki C, Shinkawa T, Nunomura K, Okamura N, Takahashi N, Takahashi N, Izumi T, Isobe T, Isobe T, Isobe T, Isobe T

Proteomics　Vol. 5　No. 5　p. 1346-1361　2005/04　Research paper (scientific journal)

In vivo cross-linking of nucleosomal histones catalyzed by nuclear transglutaminase in starfish sperm and its induction by egg jelly triggering the acrosome reaction

Nunomura K, Nunomura K, Kawakami S, Kawakami S, Shimizu T, Shimizu T, Hara T, Nakamura K, Terakawa Y, Yamasaki A, Ikegami S, Ikegami S

European Journal of Biochemistry　Vol. 270　No. 18　p. 3750-3759　2003/09　Research paper (scientific journal)

A novel histone heterodimer that appears at a specific stage of embryonic development

Ikegami S, Shimizu T, Hozumi K, Nunomura K, Takao T, Shimonishi Y

FASEB Journal　Vol. 11　No. 9　1997/12　Research paper (scientific journal)

Structure of a covalently cross-linked form of core histones present in the starfish sperm

Shimizu T, Shimizu T, Takao T, Hozumi K, Nunomura K, Ohta S, Shimonishi Y, Ikegami S, Ikegami S

Biochemistry　Vol. 36　No. 40　p. 12071-12079　1997/10　Research paper (scientific journal)

A Novel Modification of the Lysine Residue at Position 12 of Histone H4 in Starfish Sperm

NUNOMURA Kazuto, SHIMIZU Takahiko, HOZUMI Keiko, TAKAO Toshifumi, SHIMONISHI Yasutsugu, IKEGAMI Susumu

Bioscience, biotechnology, and biochemistry　Vol. 61　No. 12　p. 2151-2152　1997/01　Research paper (scientific journal)

A covalently crosslinked histone

Shlmizu T, Hozumi H, Horiike S, Nunomura K, Ikegami S, Takao T, Shimonishi Y

Nature　Vol. 380　No. 32　1996/03　Research paper (scientific journal)