論文 21
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Two-dimensionally cultured functional hepatocytes generated from human induced pluripotent stem cell-derived hepatic organoids for pharmaceutical research.
Jumpei Inui, Yukiko Ueyama-Toba, Chiharu Imamura, Wakana Nagai, Rei Asano, Hiroyuki Mizuguchi
Biomaterials Vol. 318 p. 123148-123148 2025年7月 研究論文（学術雑誌）
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Air-liquid interface culture alters the characteristics and functions of monolayers generated from human iPS cell‑derived enterocyte‑like cell organoids.
Tatsuya Inui, Yusei Uraya, Yukiko Ueyama-Toba, Hiroyuki Mizuguchi
European journal of cell biology Vol. 104 No. 2 p. 151479-151479 2025年2月5日 研究論文（学術雑誌）
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[Disease Research and Drug Development Pioneered by Female Researchers with a Focus on the Liver].
Yukiko Ueyama-Toba, Kahori Shimizu
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan Vol. 145 No. 3 p. 169-170 2025年 研究論文（学術雑誌）
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[Application of Human Liver Organoids for Pharmaceutical Research].
Yukiko Ueyama-Toba, Yanran Tong, Hiroyuki Mizuguchi
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan Vol. 145 No. 3 p. 189-194 2025年 研究論文（学術雑誌）
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Generation and application of CES1-knockout Tet-Off-regulated CYP3A4 and UGT1A1-expressing Caco-2 cells.
Michika Murata, Kentaro Okada, Masaki Takahashi, Yukiko Ueyama-Toba, Sumito Ito, Hiroyuki Mizuguchi
Toxicology letters Vol. 401 p. 158-169 2024年11月 研究論文（学術雑誌）
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Development of a hepatic differentiation method in 2D culture from primary human hepatocyte-derived organoids for pharmaceutical research
Yukiko Ueyama-Toba, Yanran Tong, Jumpei Yokota, Kazuhiro Murai, Hayato Hikita, Hidetoshi Eguchi, Tetsuo Takehara, Hiroyuki Mizuguchi
iScience Vol. 27 No. 9 p. 110778-110778 2024年9月 研究論文（学術雑誌）
出版者・発行元：Elsevier BV
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Efficient hepatocyte differentiation of primary human hepatocyte-derived organoids using three dimensional nanofibers (HYDROX) and their possible application in hepatotoxicity research.
Yanran Tong, Yukiko Ueyama-Toba, Jumpei Yokota, Hayato Matsui, Masaki Kanai, Hiroyuki Mizuguchi
Scientific reports Vol. 14 No. 1 p. 10846-10846 2024年5月13日 研究論文（学術雑誌）
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Functional intestinal monolayers from organoids derived from human iPS cells for drug discovery research.
Tatsuya Inui, Yusei Uraya, Jumpei Yokota, Tomoki Yamashita, Kanae Kawai, Kentaro Okada, Yukiko Ueyama-Toba, Hiroyuki Mizuguchi
Stem cell research & therapy Vol. 15 No. 1 p. 57-57 2024年2月29日 研究論文（学術雑誌）
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Establishment of UGT1A1-knockout human iPS-derived hepatic organoids for UGT1A1-specific kinetics and toxicity evaluation
Tomohiro Shintani, Chiharu Imamura, Yukiko Ueyama-Toba, Jumpei Inui, Akira Watanabe, Hiroyuki Mizuguchi
Molecular Therapy - Methods & Clinical Development Vol. 30 p. 429-442 2023年9月 研究論文（学術雑誌）
出版者・発行元：Elsevier BV
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Label-Free Evaluation of Maturation and Hepatotoxicity of Human iPSC-Derived Hepatocytes Using Hyperspectral Raman Imaging
Menglu Li, Yukiko Ueyama-Toba, Matthew Lindley, Gunganist Kongklad, Yasunori Nawa, Yasuaki Kumamoto, Seiichi Ishida, Yasunari Kanda, Satoshi Fujita, Hiroyuki Mizuguchi, Katsumasa Fujita
Analytical Chemistry Vol. 95 No. 24 p. 9252-9262 2023年6月 研究論文（学術雑誌）
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Biliary epithelial cell differentiation of bipotent human liver-derived organoids by 2D and 3D culture.
Yanran Tong, Yukiko Ueyama-Toba, Hiroyuki Mizuguchi
Biochemistry and biophysics reports Vol. 33 p. 101432-101432 2023年3月 研究論文（学術雑誌）
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Development of a method of passaging and freezing human iPS cell-derived hepatocytes to improve their functions.
Jumpei Inui, Yukiko Ueyama-Toba, Seiji Mitani, Hiroyuki Mizuguchi
PloS one Vol. 18 No. 5 2023年 研究論文（学術雑誌）
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Decellularized Organ-Derived Scaffold Is a Promising Carrier for Human Induced Pluripotent Stem Cells-Derived Hepatocytes.
Hideaki Kojima, Hiroshi Yagi, Hiroko Kushige, Yukiko Toda, Kazuo Takayama, Shinako Masuda, Toshinori Morisaku, Tomonori Tsuchida, Kohei Kuroda, Kazuya Hirukawa, Jumpei Inui, Kotaro Nishi, Yutaka Nakano, Masayuki Tanaka, Shutaro Hori, Yasushi Hasegawa, Yuta Abe, Minoru Kitago, Shungo Adachi, Masatoshi Tomi, Katsuhisa Matsuura, Hiroyuki Mizuguchi, Yuko Kitagawa
Cells Vol. 11 No. 8 2022年4月7日 研究論文（学術雑誌）
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Label-free assessment of hiPS-derived hepatocytes by Raman microscopy
Menglu Li, Yukiko Toba, Yasunori Nawa, Satoshi Fujita, Hiroyuki Mizuguchi, Katsumasa Fujita
Biomedical Vibrational Spectroscopy 2022: Advances in Research and Industry Vol. 11957 2022年3月2日 研究論文（国際会議プロシーディングス）
出版者・発行元：SPIE
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Development of a 3D Cell Culture System Using Amphiphilic Polydepsipeptides and Its Application to Hepatic Differentiation
Junko Enomoto, Yukiko Toba, Haruka Yamazaki, Masaki Kanai, Hiroyuki Mizuguchi, Hayato Matsui
ACS APPLIED BIO MATERIALS Vol. 4 No. 9 p. 7290-7299 2021年9月 研究論文（学術雑誌）
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Tolloid-Like 1 Negatively Regulates Hepatic Differentiation of Human Induced Pluripotent Stem Cells Through Transforming Growth Factor Beta Signaling.
Ayumi Kiso, Yukiko Toba, Susumu Tsutsumi, Sayaka Deguchi, Keisuke Igai, Saki Koshino, Yasuhito Tanaka, Kazuo Takayama, Hiroyuki Mizuguchi
Hepatology communications Vol. 4 No. 2 p. 255-267 2020年2月 研究論文（学術雑誌）
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Comparison of commercially available media for hepatic differentiation and hepatocyte maintenance.
Yukiko Toba, Sayaka Deguchi, Natsumi Mimura, Ayaka Sakamoto, Kazuo Harada, Kazumasa Hirata, Kazuo Takayama, Hiroyuki Mizuguchi
PloS one Vol. 15 No. 2 2020年 研究論文（学術雑誌）
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Modeling of Hepatic Drug Metabolism and Responses in CYP2C19 Poor Metabolizer Using Genetically Manipulated Human iPS cells.
Sayaka Deguchi, Tomoki Yamashita, Keisuke Igai, Kazuo Harada, Yukiko Toba, Kazumasa Hirata, Kazuo Takayama, Hiroyuki Mizuguchi
Drug metabolism and disposition: the biological fate of chemicals Vol. 47 No. 6 p. 632-638 2019年6月 研究論文（学術雑誌）
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FGF signal is not required for hepatoblast differentiation of human iPS cells.
Yukiko Toba, Ayumi Kiso, Souichiro Nakamae, Fuminori Sakurai, Kazuo Takayama, Hiroyuki Mizuguchi
Scientific reports Vol. 9 No. 1 p. 3713-3713 2019年3月6日 研究論文（学術雑誌）
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Enrichment of high-functioning human iPS cell-derived hepatocyte-like cells for pharmaceutical research.
Kazuo Takayama, Yasuko Hagihara, Yukiko Toba, Kiyotoshi Sekiguchi, Fuminori Sakurai, Hiroyuki Mizuguchi
Biomaterials Vol. 161 p. 24-32 2018年4月 研究論文（学術雑誌）
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Nanaomycin A Treatment Promotes Hepatoblast Differentiation from Human iPS Cells.
Souichiro Nakamae, Yukiko Toba, Kazuo Takayama, Fuminori Sakurai, Hiroyuki Mizuguchi
Stem cells and development Vol. 27 No. 6 p. 405-414 2018年3月15日 研究論文（学術雑誌）
