Development of a hepatic differentiation method in 2D culture from primary human hepatocyte-derived organoids for pharmaceutical research

Yukiko Ueyama-Toba, Yanran Tong, Jumpei Yokota, Kazuhiro Murai, Hayato Hikita, Hidetoshi Eguchi, Tetsuo Takehara, Hiroyuki Mizuguchi

iScience　Vol. 27　No. 9　p. 110778-110778　2024/09　Research paper (scientific journal)

Efficient hepatocyte differentiation of primary human hepatocyte-derived organoids using three dimensional nanofibers (HYDROX) and their possible application in hepatotoxicity research.

Yanran Tong, Yukiko Ueyama-Toba, Jumpei Yokota, Hayato Matsui, Masaki Kanai, Hiroyuki Mizuguchi

Scientific reports　Vol. 14　No. 1　p. 10846-10846　2024/05/13　Research paper (scientific journal)

Functional intestinal monolayers from organoids derived from human iPS cells for drug discovery research.

Tatsuya Inui, Yusei Uraya, Jumpei Yokota, Tomoki Yamashita, Kanae Kawai, Kentaro Okada, Yukiko Ueyama-Toba, Hiroyuki Mizuguchi

Stem cell research & therapy　Vol. 15　No. 1　p. 57-57　2024/02/29　Research paper (scientific journal)

Establishment of UGT1A1-knockout human iPS-derived hepatic organoids for UGT1A1-specific kinetics and toxicity evaluation

Tomohiro Shintani, Chiharu Imamura, Yukiko Ueyama-Toba, Jumpei Inui, Akira Watanabe, Hiroyuki Mizuguchi

Molecular Therapy - Methods & Clinical Development　Vol. 30　p. 429-442　2023/09　Research paper (scientific journal)

Label-Free Evaluation of Maturation and Hepatotoxicity of Human iPSC-Derived Hepatocytes Using Hyperspectral Raman Imaging

Menglu Li, Yukiko Ueyama-Toba, Matthew Lindley, Gunganist Kongklad, Yasunori Nawa, Yasuaki Kumamoto, Seiichi Ishida, Yasunari Kanda, Satoshi Fujita, Hiroyuki Mizuguchi, Katsumasa Fujita

Analytical Chemistry　Vol. 95　No. 24　p. 9252-9262　2023/06　Research paper (scientific journal)

Biliary epithelial cell differentiation of bipotent human liver-derived organoids by 2D and 3D culture.

Yanran Tong, Yukiko Ueyama-Toba, Hiroyuki Mizuguchi

Biochemistry and biophysics reports　Vol. 33　p. 101432-101432　2023/03　Research paper (scientific journal)

Development of a method of passaging and freezing human iPS cell-derived hepatocytes to improve their functions.

Jumpei Inui, Yukiko Ueyama-Toba, Seiji Mitani, Hiroyuki Mizuguchi

PloS one　Vol. 18　No. 5　2023　Research paper (scientific journal)

Decellularized Organ-Derived Scaffold Is a Promising Carrier for Human Induced Pluripotent Stem Cells-Derived Hepatocytes.

Hideaki Kojima, Hiroshi Yagi, Hiroko Kushige, Yukiko Toda, Kazuo Takayama, Shinako Masuda, Toshinori Morisaku, Tomonori Tsuchida, Kohei Kuroda, Kazuya Hirukawa, Jumpei Inui, Kotaro Nishi, Yutaka Nakano, Masayuki Tanaka, Shutaro Hori, Yasushi Hasegawa, Yuta Abe, Minoru Kitago, Shungo Adachi, Masatoshi Tomi, Katsuhisa Matsuura, Hiroyuki Mizuguchi, Yuko Kitagawa

Cells　Vol. 11　No. 8　2022/04/07　Research paper (scientific journal)

Label-free assessment of hiPS-derived hepatocytes by Raman microscopy

Menglu Li, Yukiko Toba, Yasunori Nawa, Satoshi Fujita, Hiroyuki Mizuguchi, Katsumasa Fujita

Biomedical Vibrational Spectroscopy 2022: Advances in Research and Industry　Vol. 11957　2022/03/02　Research paper (international conference proceedings)

Development of a 3D Cell Culture System Using Amphiphilic Polydepsipeptides and Its Application to Hepatic Differentiation

Junko Enomoto, Yukiko Toba, Haruka Yamazaki, Masaki Kanai, Hiroyuki Mizuguchi, Hayato Matsui

ACS APPLIED BIO MATERIALS　Vol. 4　No. 9　p. 7290-7299　2021/09　Research paper (scientific journal)

Tolloid-Like 1 Negatively Regulates Hepatic Differentiation of Human Induced Pluripotent Stem Cells Through Transforming Growth Factor Beta Signaling.

Ayumi Kiso, Yukiko Toba, Susumu Tsutsumi, Sayaka Deguchi, Keisuke Igai, Saki Koshino, Yasuhito Tanaka, Kazuo Takayama, Hiroyuki Mizuguchi

Hepatology communications　Vol. 4　No. 2　p. 255-267　2020/02　Research paper (scientific journal)

Comparison of commercially available media for hepatic differentiation and hepatocyte maintenance.

Yukiko Toba, Sayaka Deguchi, Natsumi Mimura, Ayaka Sakamoto, Kazuo Harada, Kazumasa Hirata, Kazuo Takayama, Hiroyuki Mizuguchi

PloS one　Vol. 15　No. 2　2020　Research paper (scientific journal)

Modeling of Hepatic Drug Metabolism and Responses in CYP2C19 Poor Metabolizer Using Genetically Manipulated Human iPS cells.

Sayaka Deguchi, Tomoki Yamashita, Keisuke Igai, Kazuo Harada, Yukiko Toba, Kazumasa Hirata, Kazuo Takayama, Hiroyuki Mizuguchi

Drug metabolism and disposition: the biological fate of chemicals　Vol. 47　No. 6　p. 632-638　2019/06　Research paper (scientific journal)

FGF signal is not required for hepatoblast differentiation of human iPS cells.

Yukiko Toba, Ayumi Kiso, Souichiro Nakamae, Fuminori Sakurai, Kazuo Takayama, Hiroyuki Mizuguchi

Scientific reports　Vol. 9　No. 1　p. 3713-3713　2019/03/06　Research paper (scientific journal)

Enrichment of high-functioning human iPS cell-derived hepatocyte-like cells for pharmaceutical research.

Kazuo Takayama, Yasuko Hagihara, Yukiko Toba, Kiyotoshi Sekiguchi, Fuminori Sakurai, Hiroyuki Mizuguchi

Biomaterials　Vol. 161　p. 24-32　2018/04　Research paper (scientific journal)

Nanaomycin A Treatment Promotes Hepatoblast Differentiation from Human iPS Cells.

Souichiro Nakamae, Yukiko Toba, Kazuo Takayama, Fuminori Sakurai, Hiroyuki Mizuguchi

Stem cells and development　Vol. 27　No. 6　p. 405-414　2018/03/15　Research paper (scientific journal)