筑波大学大学院 生命環境科学研究科 生物科学専攻
2017年4月 ～ 2018年3月
九州大学大学院 農学研究科 農芸化学専攻
1990年4月 ～ 1992年3月
九州大学 農学部 農芸化学専攻 醗酵学講座
1986年4月 ～ 1990年3月
日本生物工学会
ライフサイエンス / 応用分子細胞生物学 / 化合物スクリーニング、ターゲットバリデーション、MOA解析
Applying deep learning to iterative screening of medium-sized molecules for protein-protein interaction-targeted drug discovery.
Yugo Shimizu, Tomoki Yonezawa, Yu Bao, Junichi Sakamoto, Mariko Yokogawa, Toshio Furuya, Masanori Osawa, Kazuyoshi Ikeda
Chemical communications (Cambridge, England) Vol. 59 No. 44 p. 6722-6725 2023年5月30日 研究論文（学術雑誌）
Identification of novel inhibitors of Keap1/Nrf2 by a promising method combining protein-protein interaction-oriented library and machine learning.
Yugo Shimizu, Tomoki Yonezawa, Junichi Sakamoto, Toshio Furuya, Masanori Osawa, Kazuyoshi Ikeda
Scientific reports Vol. 11 No. 1 p. 7420-7420 2021年4月1日 研究論文（学術雑誌）
Discovery and characterization of a small-molecule enteropeptidase inhibitor, SCO-792.
Masako Sasaki, Ikuo Miyahisa, Sachiko Itono, Hiroaki Yashiro, Hideyuki Hiyoshi, Kazue Tsuchimori, Ken-Ichi Hamagami, Yusuke Moritoh, Masanori Watanabe, Kimio Tohyama, Minoru Sasaki, Jun-Ichi Sakamoto, Tomohiro Kawamoto
Pharmacology research & perspectives Vol. 7 No. 5 2019年10月 研究論文（学術雑誌）
Discovery of an Irreversible and Cell-Active BCL6 Inhibitor Selectively Targeting Cys53 Located at the Protein-Protein Interaction Interface.
Tomoya Sameshima, Takeshi Yamamoto, Osamu Sano, Satoshi Sogabe, Shigeru Igaki, Kotaro Sakamoto, Koh Ida, Mika Gotou, Yasuhiro Imaeda, Junichi Sakamoto, Ikuo Miyahisa
Biochemistry Vol. 57 No. 8 p. 1369-1379 2018年2月27日 研究論文（学術雑誌）
Identification and Characterization of a New Series of Ghrelin O-Acyl Transferase Inhibitors.
Mariko Yoneyama-Hirozane, Kohei Deguchi, Takeshi Hirakawa, Tsuyoshi Ishii, Tomoyuki Odani, Junji Matsui, Yoshihide Nakano, Kenichi Imahashi, Nobuyuki Takakura, Ikumi Chisaki, Shiro Takekawa, Junichi Sakamoto
SLAS discovery : advancing life sciences R & D Vol. 23 No. 2 p. 154-163 2018年2月 研究論文（学術雑誌）
Antiobesity and emetic effects of a short-length peptide YY analog and its PEGylated and alkylated derivatives.
Ayumu Niida, Yoko Kanematsu-Yamaki, Tomoko Asakawa, Yoshimasa Ishimura, Hisashi Fujita, Kouta Matsumiya, Naoki Nishizawa, Yusuke Adachi, Taisuke Mochida, Kazue Tsuchimori, Mariko Yoneyama-Hirozane, Junichi Sakamoto, Hideki Hirabayashi, Hideo Fukui, Shiro Takekawa, Taiji Asami
Bioorganic & medicinal chemistry Vol. 26 No. 3 p. 566-572 2018年2月1日 研究論文（学術雑誌）
Bombesin receptor subtype-3-expressing neurons regulate energy homeostasis through a novel neuronal pathway in the hypothalamus.
Minoru Maruyama, Natsu Hotta, Yasunori Nio, Kenichi Hamagami, Toshimi Nagi, Masaaki Funata, Junichi Sakamoto, Masanori Nakakariya, Nobuyuki Amano, Mayumi Nishida, Tomohiro Okawa, Yasuyoshi Arikawa, Shinobu Sasaki, Shizuo Kasai, Yasutaka Nagisa, Yugo Habata, Masaaki Mori
Brain and behavior Vol. 8 No. 1 2018年1月 研究論文（学術雑誌）
Differential effects of selective agonists of neuromedin U1 and U2 receptors in obese and diabetic mice.
Hiroaki Nagai, Tomoko Kaisho, Kotaro Yokoyama, Tomoko Asakawa, Hisashi Fujita, Kouta Matsumiya, Jiro Noguchi, Kazue Tsuchimori, Naoki Nishizawa, Yoko Kanematsu-Yamaki, Katsuko Dote, Hiroshi Inooka, Jun-Ichi Sakamoto, Tetsuya Ohtaki, Taiji Asami, Shiro Takekawa
British journal of pharmacology Vol. 175 No. 2 p. 359-373 2018年1月 研究論文（学術雑誌）
A potent neuromedin U receptor 2-selective alkylated peptide.
Naoki Nishizawa, Yoko Kanematsu-Yamaki, Masaaki Funata, Hiroaki Nagai, Ayako Shimizu, Hisashi Fujita, Junichi Sakamoto, Shiro Takekawa, Taiji Asami
Bioorganic & medicinal chemistry letters Vol. 27 No. 20 p. 4626-4629 2017年10月15日 研究論文（学術雑誌）
High-Throughput Quantitative Intrinsic Thiol Reactivity Evaluation Using a Fluorescence-Based Competitive Endpoint Assay.
Tomoya Sameshima, Ikuo Miyahisa, Seiji Yamasaki, Mika Gotou, Toshitake Kobayashi, Junichi Sakamoto
SLAS discovery : advancing life sciences R & D Vol. 22 No. 9 p. 1168-1174 2017年10月 研究論文（学術雑誌）
Discovery of a novel B-cell lymphoma 6 (BCL6)-corepressor interaction inhibitor by utilizing structure-based drug design.
Takeshi Yasui, Takeshi Yamamoto, Nozomu Sakai, Kouhei Asano, Takafumi Takai, Yayoi Yoshitomi, Melinda Davis, Terufumi Takagi, Kotaro Sakamoto, Satoshi Sogabe, Yusuke Kamada, Weston Lane, Gyorgy Snell, Masashi Iwata, Masayuki Goto, Hiroshi Inooka, Jun-Ichi Sakamoto, Yoshihisa Nakada, Yasuhiro Imaeda
Bioorganic & medicinal chemistry Vol. 25 No. 17 p. 4876-4886 2017年9月1日 研究論文（学術雑誌）
Identification of cytidine-5-triphosphate synthase1-selective inhibitory peptide from random peptide library displayed on T7 phage.
Kotaro Sakamoto, Yoshihiro Ishibashi, Ryutaro Adachi, Shin-Ichi Matsumoto, Hideyuki Oki, Yusuke Kamada, Satoshi Sogabe, Yumi Zama, Jun-Ichi Sakamoto, Akiyoshi Tani
Peptides Vol. 94 p. 56-63 2017年8月 研究論文（学術雑誌）
Potent Body Weight-Lowering Effect of a Neuromedin U Receptor 2-selective PEGylated Peptide.
Yoko Kanematsu-Yamaki, Naoki Nishizawa, Tomoko Kaisho, Hiroaki Nagai, Taisuke Mochida, Tomoko Asakawa, Hiroshi Inooka, Katsuko Dote, Hisashi Fujita, Kouta Matsumiya, Hideki Hirabayashi, Junichi Sakamoto, Tetsuya Ohtaki, Shiro Takekawa, Taiji Asami
Journal of medicinal chemistry Vol. 60 No. 14 p. 6089-6097 2017年7月27日 研究論文（学術雑誌）
Crystal Structure of a Human K-Ras G12D Mutant in Complex with GDP and the Cyclic Inhibitory Peptide KRpep-2d.
Satoshi Sogabe, Yusuke Kamada, Masanori Miwa, Ayumu Niida, Tomoya Sameshima, Masahiro Kamaura, Kazuko Yonemori, Shigekazu Sasaki, Jun-Ichi Sakamoto, Kotaro Sakamoto
ACS medicinal chemistry letters Vol. 8 No. 7 p. 732-736 2017年7月13日 研究論文（学術雑誌）
Discovery of a B-Cell Lymphoma 6 Protein-Protein Interaction Inhibitor by a Biophysics-Driven Fragment-Based Approach.
Yusuke Kamada, Nozomu Sakai, Satoshi Sogabe, Koh Ida, Hideyuki Oki, Kotaro Sakamoto, Weston Lane, Gyorgy Snell, Motoo Iida, Yasuhiro Imaeda, Junichi Sakamoto, Junji Matsui
Journal of medicinal chemistry Vol. 60 No. 10 p. 4358-4368 2017年5月25日 研究論文（学術雑誌）
Discovery of a Kelch-like ECH-associated protein 1-inhibitory tetrapeptide and its structural characterization.
Satoshi Sogabe, Kotaro Sakamoto, Yusuke Kamada, Akito Kadotani, Yasunori Fukuda, Jun-Ichi Sakamoto
Biochemical and biophysical research communications Vol. 486 No. 3 p. 620-625 2017年5月6日 研究論文（学術雑誌）
A Selective Bombesin Receptor Subtype 3 Agonist Promotes Weight Loss in Male Diet-Induced-Obese Rats With Circadian Rhythm Change.
Yasunori Nio, Natsu Hotta, Minoru Maruyama, Kenichi Hamagami, Toshimi Nagi, Masaaki Funata, Junichi Sakamoto, Masanori Nakakariya, Nobuyuki Amano, Tomohiro Okawa, Yasuyoshi Arikawa, Shinobu Sasaki, Shoki Okuda, Shizuo Kasai, Yugo Habata, Yasutaka Nagisa
Endocrinology Vol. 158 No. 5 p. 1298-1313 2017年5月1日 研究論文（学術雑誌）
Discovery of Human Intestinal MGAT Inhibitors Using High-Throughput Mass Spectrometry.
Ryutaro Adachi, Tsuyoshi Ishii, Shinichi Matsumoto, Takuya Satou, Junichi Sakamoto, Tomohiro Kawamoto
SLAS discovery : advancing life sciences R & D Vol. 22 No. 4 p. 360-365 2017年4月 研究論文（学術雑誌）
K-Ras(G12D)-selective inhibitory peptides generated by random peptide T7 phage display technology.
Kotaro Sakamoto, Yusuke Kamada, Tomoya Sameshima, Masahiro Yaguchi, Ayumu Niida, Shigekazu Sasaki, Masanori Miwa, Shoichi Ohkubo, Jun-Ichi Sakamoto, Masahiro Kamaura, Nobuo Cho, Akiyoshi Tani
Biochemical and biophysical research communications Vol. 484 No. 3 p. 605-611 2017年3月11日 研究論文（学術雑誌）
Novel DOCK2-selective inhibitory peptide that suppresses B-cell line migration.
Kotaro Sakamoto, Yusuke Adachi, Yusaku Komoike, Yusuke Kamada, Ryokichi Koyama, Yasunori Fukuda, Akito Kadotani, Taiji Asami, Jun-Ichi Sakamoto
Biochemical and biophysical research communications Vol. 483 No. 1 p. 183-190 2017年1月29日 研究論文（学術雑誌）
Discovery of GPX4 inhibitory peptides from random peptide T7 phage display and subsequent structural analysis.
Kotaro Sakamoto, Satoshi Sogabe, Yusuke Kamada, Shin-Ichi Matsumoto, Akito Kadotani, Jun-Ichi Sakamoto, Akiyoshi Tani
Biochemical and biophysical research communications Vol. 482 No. 2 p. 195-201 2017年1月8日 研究論文（学術雑誌）
Discovery of high-affinity BCL6-binding peptide and its structure-activity relationship.
Kotaro Sakamoto, Satoshi Sogabe, Yusuke Kamada, Nozomu Sakai, Kouhei Asano, Mie Yoshimatsu, Kou Ida, Yasuhiro Imaeda, Jun-Ichi Sakamoto
Biochemical and biophysical research communications Vol. 482 No. 2 p. 310-316 2017年1月8日 研究論文（学術雑誌）
Pharmacological characterization of a series of aryl-sulfonamide derivatives that potently and selectively inhibit monoacylglycerol acyltransferase 2.
Ryutaro Adachi, Tsuyoshi Ishii, Kazumasa Ogawa, Shinichi Matsumoto, Takuya Satou, Junichi Sakamoto, Kenjiro Sato, Tomohiro Kawamoto
European journal of pharmacology Vol. 791 p. 569-577 2016年11月15日 研究論文（学術雑誌）
Structure-activity relationships and key structural feature of pyridyloxybenzene-acylsulfonamides as new, potent, and selective peroxisome proliferator-activated receptor (PPAR) γ Agonists.
Kentaro Rikimaru, Takeshi Wakabayashi, Hidenori Abe, Taisuke Tawaraishi, Hiroshi Imoto, Jinichi Yonemori, Hideki Hirose, Katsuhito Murase, Takanori Matsuo, Mitsuharu Matsumoto, Chisako Nomura, Hiroko Tsuge, Naoto Arimura, Kazutoshi Kawakami, Junichi Sakamoto, Miyuki Funami, Clifford D Mol, Gyorgy P Snell, Kenneth A Bragstad, Bi-Ching Sang, Douglas R Dougan, Toshimasa Tanaka, Nozomi Katayama, Yoshiaki Horiguchi, Yu Momose
Bioorganic & medicinal chemistry Vol. 20 No. 10 p. 3332-58 2012年5月15日 研究論文（学術雑誌）
A new class of non-thiazolidinedione, non-carboxylic-acid-based highly selective peroxisome proliferator-activated receptor (PPAR) γ agonists: design and synthesis of benzylpyrazole acylsulfonamides.
Kentaro Rikimaru, Takeshi Wakabayashi, Hidenori Abe, Hiroshi Imoto, Tsuyoshi Maekawa, Osamu Ujikawa, Katsuhito Murase, Takanori Matsuo, Mitsuharu Matsumoto, Chisako Nomura, Hiroko Tsuge, Naoto Arimura, Kazutoshi Kawakami, Junichi Sakamoto, Miyuki Funami, Clifford D Mol, Gyorgy P Snell, Kenneth A Bragstad, Bi-Ching Sang, Douglas R Dougan, Toshimasa Tanaka, Nozomi Katayama, Yoshiaki Horiguchi, Yu Momose
Bioorganic & medicinal chemistry Vol. 20 No. 2 p. 714-33 2012年1月15日 研究論文（学術雑誌）
Design, synthesis, and structure-activity relationships of spirolactones bearing 2-ureidobenzothiophene as acetyl-CoA carboxylases inhibitors.
Tohru Yamashita, Makoto Kamata, Satoshi Endo, Mitsuo Yamamoto, Keiko Kakegawa, Hiroyuki Watanabe, Katsuhiko Miwa, Toru Yamano, Masaaki Funata, Jyun-Ichi Sakamoto, Akiyoshi Tani, Clifford D Mol, Hua Zou, Douglas R Dougan, Biching Sang, Gyorgy Snell, Kohji Fukatsu
Bioorganic & medicinal chemistry letters Vol. 21 No. 21 p. 6314-8 2011年11月1日 研究論文（学術雑誌）
A novel oxyiminoalkanoic acid derivative, TAK-559, activates human peroxisome proliferator-activated receptor subtypes.
Junichi Sakamoto, Hiroyuki Kimura, Shinji Moriyama, Hiroshi Imoto, Yu Momose, Hiroyuki Odaka, Hidekazu Sawada
European journal of pharmacology Vol. 495 No. 1 p. 17-26 2004年7月8日 研究論文（学術雑誌）
Studies on non-thiazolidinedione antidiabetic agents. 3. Preparation and biological activity of the metabolites of TAK-559.
Hiroshi Imoto, Mitsuharu Matsumoto, Hiroyuki Odaka, Junichi Sakamoto, Hiroyuki Kimura, Masami Nonaka, Yutaka Kiyota, Yu Momose
Chemical & pharmaceutical bulletin Vol. 52 No. 1 p. 120-4 2004年1月 研究論文（学術雑誌）
Activation of human peroxisome proliferator-activated receptor (PPAR) subtypes by pioglitazone.
J Sakamoto, H Kimura, S Moriyama, H Odaka, Y Momose, Y Sugiyama, H Sawada
Biochemical and biophysical research communications Vol. 278 No. 3 p. 704-11 2000年11月30日 研究論文（学術雑誌）
High-level expression of human fibroblast growth factor-9 N33 in Escherichia coli
M Kuriyama, J Sakamoto, M Nakatu, T Kurokawa, H Sawada
J Ferment Bioeng. Vol. 80 No. 4 p. 327-333 1995年
