顔写真

PHOTO

Sakamoto Junichi
坂本　潤一
Sakamoto Junichi
坂本　潤一
Graduate School of Pharmaceutical Sciences, Specially Appointed Associate Professor (Full Time)

Research History 3

  1. 2024/07 - Present
    Graduate School of Pharmaceutical Science, Osaka university　Compound Library Screening Center　Specially Appointed Associate Professor

  2. 2017/07 - 2024/06
    Axcelead Drug Discovery Partners Inc.　Discovery Biology, HTS and Compound Evaluation

  3. 1992/04 - 2017/06
    Takeda Pharmaceutical Company Limited　Biomolecular Research Laboratory　Director

Education 3

  1. 筑波大学大学院　生命環境科学研究科　生物科学専攻

    2017/04 - 2018/03

  2. 九州大学大学院　農学研究科　農芸化学専攻

    1990/04 - 1992/03

  3. 九州大学　農学部　農芸化学専攻 醗酵学講座

    1986/04 - 1990/03

Professional Memberships 1

  1. 日本生物工学会

Research Areas 1

  1. Life sciences / Applied molecular and cellular biology / Compound Screening, Target Validation, MOA confirmation

Papers 30

  1. Applying deep learning to iterative screening of medium-sized molecules for protein-protein interaction-targeted drug discovery.

    Yugo Shimizu, Tomoki Yonezawa, Yu Bao, Junichi Sakamoto, Mariko Yokogawa, Toshio Furuya, Masanori Osawa, Kazuyoshi Ikeda

    Chemical communications (Cambridge, England)　Vol. 59　No. 44　p. 6722-6725　2023/05/30　Research paper (scientific journal)

  2. Identification of novel inhibitors of Keap1/Nrf2 by a promising method combining protein-protein interaction-oriented library and machine learning.

    Yugo Shimizu, Tomoki Yonezawa, Junichi Sakamoto, Toshio Furuya, Masanori Osawa, Kazuyoshi Ikeda

    Scientific reports　Vol. 11　No. 1　p. 7420-7420　2021/04/01　Research paper (scientific journal)

  3. Discovery and characterization of a small-molecule enteropeptidase inhibitor, SCO-792.

    Masako Sasaki, Ikuo Miyahisa, Sachiko Itono, Hiroaki Yashiro, Hideyuki Hiyoshi, Kazue Tsuchimori, Ken-Ichi Hamagami, Yusuke Moritoh, Masanori Watanabe, Kimio Tohyama, Minoru Sasaki, Jun-Ichi Sakamoto, Tomohiro Kawamoto

    Pharmacology research & perspectives　Vol. 7　No. 5　2019/10　Research paper (scientific journal)

  4. Discovery of an Irreversible and Cell-Active BCL6 Inhibitor Selectively Targeting Cys53 Located at the Protein-Protein Interaction Interface.

    Tomoya Sameshima, Takeshi Yamamoto, Osamu Sano, Satoshi Sogabe, Shigeru Igaki, Kotaro Sakamoto, Koh Ida, Mika Gotou, Yasuhiro Imaeda, Junichi Sakamoto, Ikuo Miyahisa

    Biochemistry　Vol. 57　No. 8　p. 1369-1379　2018/02/27　Research paper (scientific journal)

  5. Identification and Characterization of a New Series of Ghrelin O-Acyl Transferase Inhibitors.

    Mariko Yoneyama-Hirozane, Kohei Deguchi, Takeshi Hirakawa, Tsuyoshi Ishii, Tomoyuki Odani, Junji Matsui, Yoshihide Nakano, Kenichi Imahashi, Nobuyuki Takakura, Ikumi Chisaki, Shiro Takekawa, Junichi Sakamoto

    SLAS discovery : advancing life sciences R & D　Vol. 23　No. 2　p. 154-163　2018/02　Research paper (scientific journal)

  6. Antiobesity and emetic effects of a short-length peptide YY analog and its PEGylated and alkylated derivatives.

    Ayumu Niida, Yoko Kanematsu-Yamaki, Tomoko Asakawa, Yoshimasa Ishimura, Hisashi Fujita, Kouta Matsumiya, Naoki Nishizawa, Yusuke Adachi, Taisuke Mochida, Kazue Tsuchimori, Mariko Yoneyama-Hirozane, Junichi Sakamoto, Hideki Hirabayashi, Hideo Fukui, Shiro Takekawa, Taiji Asami

    Bioorganic & medicinal chemistry　Vol. 26　No. 3　p. 566-572　2018/02/01　Research paper (scientific journal)

  7. Bombesin receptor subtype-3-expressing neurons regulate energy homeostasis through a novel neuronal pathway in the hypothalamus.

    Minoru Maruyama, Natsu Hotta, Yasunori Nio, Kenichi Hamagami, Toshimi Nagi, Masaaki Funata, Junichi Sakamoto, Masanori Nakakariya, Nobuyuki Amano, Mayumi Nishida, Tomohiro Okawa, Yasuyoshi Arikawa, Shinobu Sasaki, Shizuo Kasai, Yasutaka Nagisa, Yugo Habata, Masaaki Mori

    Brain and behavior　Vol. 8　No. 1　2018/01　Research paper (scientific journal)

  8. Differential effects of selective agonists of neuromedin U1 and U2 receptors in obese and diabetic mice.

    Hiroaki Nagai, Tomoko Kaisho, Kotaro Yokoyama, Tomoko Asakawa, Hisashi Fujita, Kouta Matsumiya, Jiro Noguchi, Kazue Tsuchimori, Naoki Nishizawa, Yoko Kanematsu-Yamaki, Katsuko Dote, Hiroshi Inooka, Jun-Ichi Sakamoto, Tetsuya Ohtaki, Taiji Asami, Shiro Takekawa

    British journal of pharmacology　Vol. 175　No. 2　p. 359-373　2018/01　Research paper (scientific journal)

  9. A potent neuromedin U receptor 2-selective alkylated peptide.

    Naoki Nishizawa, Yoko Kanematsu-Yamaki, Masaaki Funata, Hiroaki Nagai, Ayako Shimizu, Hisashi Fujita, Junichi Sakamoto, Shiro Takekawa, Taiji Asami

    Bioorganic & medicinal chemistry letters　Vol. 27　No. 20　p. 4626-4629　2017/10/15　Research paper (scientific journal)

  10. High-Throughput Quantitative Intrinsic Thiol Reactivity Evaluation Using a Fluorescence-Based Competitive Endpoint Assay.

    Tomoya Sameshima, Ikuo Miyahisa, Seiji Yamasaki, Mika Gotou, Toshitake Kobayashi, Junichi Sakamoto

    SLAS discovery : advancing life sciences R & D　Vol. 22　No. 9　p. 1168-1174　2017/10　Research paper (scientific journal)

  11. Discovery of a novel B-cell lymphoma 6 (BCL6)-corepressor interaction inhibitor by utilizing structure-based drug design.

    Takeshi Yasui, Takeshi Yamamoto, Nozomu Sakai, Kouhei Asano, Takafumi Takai, Yayoi Yoshitomi, Melinda Davis, Terufumi Takagi, Kotaro Sakamoto, Satoshi Sogabe, Yusuke Kamada, Weston Lane, Gyorgy Snell, Masashi Iwata, Masayuki Goto, Hiroshi Inooka, Jun-Ichi Sakamoto, Yoshihisa Nakada, Yasuhiro Imaeda

    Bioorganic & medicinal chemistry　Vol. 25　No. 17　p. 4876-4886　2017/09/01　Research paper (scientific journal)

  12. Identification of cytidine-5-triphosphate synthase1-selective inhibitory peptide from random peptide library displayed on T7 phage.

    Kotaro Sakamoto, Yoshihiro Ishibashi, Ryutaro Adachi, Shin-Ichi Matsumoto, Hideyuki Oki, Yusuke Kamada, Satoshi Sogabe, Yumi Zama, Jun-Ichi Sakamoto, Akiyoshi Tani

    Peptides　Vol. 94　p. 56-63　2017/08　Research paper (scientific journal)

  13. Potent Body Weight-Lowering Effect of a Neuromedin U Receptor 2-selective PEGylated Peptide.

    Yoko Kanematsu-Yamaki, Naoki Nishizawa, Tomoko Kaisho, Hiroaki Nagai, Taisuke Mochida, Tomoko Asakawa, Hiroshi Inooka, Katsuko Dote, Hisashi Fujita, Kouta Matsumiya, Hideki Hirabayashi, Junichi Sakamoto, Tetsuya Ohtaki, Shiro Takekawa, Taiji Asami

    Journal of medicinal chemistry　Vol. 60　No. 14　p. 6089-6097　2017/07/27　Research paper (scientific journal)

  14. Crystal Structure of a Human K-Ras G12D Mutant in Complex with GDP and the Cyclic Inhibitory Peptide KRpep-2d.

    Satoshi Sogabe, Yusuke Kamada, Masanori Miwa, Ayumu Niida, Tomoya Sameshima, Masahiro Kamaura, Kazuko Yonemori, Shigekazu Sasaki, Jun-Ichi Sakamoto, Kotaro Sakamoto

    ACS medicinal chemistry letters　Vol. 8　No. 7　p. 732-736　2017/07/13　Research paper (scientific journal)

  15. Discovery of a B-Cell Lymphoma 6 Protein-Protein Interaction Inhibitor by a Biophysics-Driven Fragment-Based Approach.

    Yusuke Kamada, Nozomu Sakai, Satoshi Sogabe, Koh Ida, Hideyuki Oki, Kotaro Sakamoto, Weston Lane, Gyorgy Snell, Motoo Iida, Yasuhiro Imaeda, Junichi Sakamoto, Junji Matsui

    Journal of medicinal chemistry　Vol. 60　No. 10　p. 4358-4368　2017/05/25　Research paper (scientific journal)

  16. Discovery of a Kelch-like ECH-associated protein 1-inhibitory tetrapeptide and its structural characterization.

    Satoshi Sogabe, Kotaro Sakamoto, Yusuke Kamada, Akito Kadotani, Yasunori Fukuda, Jun-Ichi Sakamoto

    Biochemical and biophysical research communications　Vol. 486　No. 3　p. 620-625　2017/05/06　Research paper (scientific journal)

  17. A Selective Bombesin Receptor Subtype 3 Agonist Promotes Weight Loss in Male Diet-Induced-Obese Rats With Circadian Rhythm Change.

    Yasunori Nio, Natsu Hotta, Minoru Maruyama, Kenichi Hamagami, Toshimi Nagi, Masaaki Funata, Junichi Sakamoto, Masanori Nakakariya, Nobuyuki Amano, Tomohiro Okawa, Yasuyoshi Arikawa, Shinobu Sasaki, Shoki Okuda, Shizuo Kasai, Yugo Habata, Yasutaka Nagisa

    Endocrinology　Vol. 158　No. 5　p. 1298-1313　2017/05/01　Research paper (scientific journal)

  18. Discovery of Human Intestinal MGAT Inhibitors Using High-Throughput Mass Spectrometry.

    Ryutaro Adachi, Tsuyoshi Ishii, Shinichi Matsumoto, Takuya Satou, Junichi Sakamoto, Tomohiro Kawamoto

    SLAS discovery : advancing life sciences R & D　Vol. 22　No. 4　p. 360-365　2017/04　Research paper (scientific journal)

  19. K-Ras(G12D)-selective inhibitory peptides generated by random peptide T7 phage display technology.

    Kotaro Sakamoto, Yusuke Kamada, Tomoya Sameshima, Masahiro Yaguchi, Ayumu Niida, Shigekazu Sasaki, Masanori Miwa, Shoichi Ohkubo, Jun-Ichi Sakamoto, Masahiro Kamaura, Nobuo Cho, Akiyoshi Tani

    Biochemical and biophysical research communications　Vol. 484　No. 3　p. 605-611　2017/03/11　Research paper (scientific journal)

  20. Novel DOCK2-selective inhibitory peptide that suppresses B-cell line migration.

    Kotaro Sakamoto, Yusuke Adachi, Yusaku Komoike, Yusuke Kamada, Ryokichi Koyama, Yasunori Fukuda, Akito Kadotani, Taiji Asami, Jun-Ichi Sakamoto

    Biochemical and biophysical research communications　Vol. 483　No. 1　p. 183-190　2017/01/29　Research paper (scientific journal)

  21. Discovery of GPX4 inhibitory peptides from random peptide T7 phage display and subsequent structural analysis.

    Kotaro Sakamoto, Satoshi Sogabe, Yusuke Kamada, Shin-Ichi Matsumoto, Akito Kadotani, Jun-Ichi Sakamoto, Akiyoshi Tani

    Biochemical and biophysical research communications　Vol. 482　No. 2　p. 195-201　2017/01/08　Research paper (scientific journal)

  22. Discovery of high-affinity BCL6-binding peptide and its structure-activity relationship.

    Kotaro Sakamoto, Satoshi Sogabe, Yusuke Kamada, Nozomu Sakai, Kouhei Asano, Mie Yoshimatsu, Kou Ida, Yasuhiro Imaeda, Jun-Ichi Sakamoto

    Biochemical and biophysical research communications　Vol. 482　No. 2　p. 310-316　2017/01/08　Research paper (scientific journal)

  23. Pharmacological characterization of a series of aryl-sulfonamide derivatives that potently and selectively inhibit monoacylglycerol acyltransferase 2.

    Ryutaro Adachi, Tsuyoshi Ishii, Kazumasa Ogawa, Shinichi Matsumoto, Takuya Satou, Junichi Sakamoto, Kenjiro Sato, Tomohiro Kawamoto

    European journal of pharmacology　Vol. 791　p. 569-577　2016/11/15　Research paper (scientific journal)

  24. Structure-activity relationships and key structural feature of pyridyloxybenzene-acylsulfonamides as new, potent, and selective peroxisome proliferator-activated receptor (PPAR) γ Agonists.

    Kentaro Rikimaru, Takeshi Wakabayashi, Hidenori Abe, Taisuke Tawaraishi, Hiroshi Imoto, Jinichi Yonemori, Hideki Hirose, Katsuhito Murase, Takanori Matsuo, Mitsuharu Matsumoto, Chisako Nomura, Hiroko Tsuge, Naoto Arimura, Kazutoshi Kawakami, Junichi Sakamoto, Miyuki Funami, Clifford D Mol, Gyorgy P Snell, Kenneth A Bragstad, Bi-Ching Sang, Douglas R Dougan, Toshimasa Tanaka, Nozomi Katayama, Yoshiaki Horiguchi, Yu Momose

    Bioorganic & medicinal chemistry　Vol. 20　No. 10　p. 3332-58　2012/05/15　Research paper (scientific journal)

  25. A new class of non-thiazolidinedione, non-carboxylic-acid-based highly selective peroxisome proliferator-activated receptor (PPAR) γ agonists: design and synthesis of benzylpyrazole acylsulfonamides.

    Kentaro Rikimaru, Takeshi Wakabayashi, Hidenori Abe, Hiroshi Imoto, Tsuyoshi Maekawa, Osamu Ujikawa, Katsuhito Murase, Takanori Matsuo, Mitsuharu Matsumoto, Chisako Nomura, Hiroko Tsuge, Naoto Arimura, Kazutoshi Kawakami, Junichi Sakamoto, Miyuki Funami, Clifford D Mol, Gyorgy P Snell, Kenneth A Bragstad, Bi-Ching Sang, Douglas R Dougan, Toshimasa Tanaka, Nozomi Katayama, Yoshiaki Horiguchi, Yu Momose

    Bioorganic & medicinal chemistry　Vol. 20　No. 2　p. 714-33　2012/01/15　Research paper (scientific journal)

  26. Design, synthesis, and structure-activity relationships of spirolactones bearing 2-ureidobenzothiophene as acetyl-CoA carboxylases inhibitors.

    Tohru Yamashita, Makoto Kamata, Satoshi Endo, Mitsuo Yamamoto, Keiko Kakegawa, Hiroyuki Watanabe, Katsuhiko Miwa, Toru Yamano, Masaaki Funata, Jyun-Ichi Sakamoto, Akiyoshi Tani, Clifford D Mol, Hua Zou, Douglas R Dougan, Biching Sang, Gyorgy Snell, Kohji Fukatsu

    Bioorganic & medicinal chemistry letters　Vol. 21　No. 21　p. 6314-8　2011/11/01　Research paper (scientific journal)

  27. A novel oxyiminoalkanoic acid derivative, TAK-559, activates human peroxisome proliferator-activated receptor subtypes.

    Junichi Sakamoto, Hiroyuki Kimura, Shinji Moriyama, Hiroshi Imoto, Yu Momose, Hiroyuki Odaka, Hidekazu Sawada

    European journal of pharmacology　Vol. 495　No. 1　p. 17-26　2004/07/08　Research paper (scientific journal)

  28. Studies on non-thiazolidinedione antidiabetic agents. 3. Preparation and biological activity of the metabolites of TAK-559.

    Hiroshi Imoto, Mitsuharu Matsumoto, Hiroyuki Odaka, Junichi Sakamoto, Hiroyuki Kimura, Masami Nonaka, Yutaka Kiyota, Yu Momose

    Chemical & pharmaceutical bulletin　Vol. 52　No. 1　p. 120-4　2004/01　Research paper (scientific journal)

  29. Activation of human peroxisome proliferator-activated receptor (PPAR) subtypes by pioglitazone.

    J Sakamoto, H Kimura, S Moriyama, H Odaka, Y Momose, Y Sugiyama, H Sawada

    Biochemical and biophysical research communications　Vol. 278　No. 3　p. 704-11　2000/11/30　Research paper (scientific journal)

  30. High-level expression of human fibroblast growth factor-9 N33 in Escherichia coli

    M Kuriyama, J Sakamoto, M Nakatu, T Kurokawa, H Sawada

    J Ferment Bioeng.　Vol. 80　No. 4　p. 327-333　1995