Effect of Anti-PEG Antibody on Immune Response of mRNA-Loaded Lipid Nanoparticles.

Daiki Omata, Eigo Kawahara, Lisa Munakata, Hiroki Tanaka, Hidetaka Akita, Yasuo Yoshioka, Ryo Suzuki

Molecular pharmaceutics　2024/09/26　Research paper (scientific journal)

Lipid Nanoparticle with 1,2-Di-O-octadecenyl-3-trimethylammonium-propane as a Component Lipid Confers Potent Responses of Th1 Cells and Antibody against Vaccine Antigen.

Atsushi Kawai, Masahiro Noda, Haruki Hirata, Lisa Munakata, Teppei Matsuda, Daiki Omata, Naoki Takemura, Sakura Onoe, Mika Hirose, Takayuki Kato, Tatsuya Saitoh, Toshiro Hirai, Ryo Suzuki, Yasuo Yoshioka

ACS nano　Vol. 18　No. 26　p. 16589-16609　2024/07/02　Research paper (scientific journal)

SARS-CoV-2感染初期におけるJAK阻害はマウスにおいて内因性抗ウイルス活性の低下とともに腎障害を悪化させる(JAK inhibition in the early phase of SARS-CoV-2 infection exacerbates kidney injury along with decreased endogenous antiviral activity in mice)

尾花 理徳, 坂井 響, 禿 宏保, 徳納 渚沙, 山本 彩葉, 岡田 欣晃, 吉岡 靖雄, 藤尾 慈

日本腎臓学会誌　Vol. 66　No. 4　p. 610-610　2024/06

Adjuvant-free parenterally injectable vaccine platform that harnesses previously induced IgG as an antigen delivery carrier

Atsushi Kawai, Haruki Hirata, Nagisa Tokunoh, Chikako Ono, Yoshiharu Matsuura, Toshiro Hirai, Yasuo Yoshioka

Biochemical and Biophysical Research Communications　Vol. 711　p. 149919-149919　2024/06　Research paper (scientific journal)

JAK inhibition during the early phase of SARS-CoV-2 infection worsens kidney injury by suppressing endogenous antiviral activity in mice.

Hibiki Sakai, Hiroyasu Kamuro, Nagisa Tokunoh, Takeshi Izawa, Shigeyuki Tamiya, Ayaha Yamamoto, Shota Tanaka, Daisuke Okuzaki, Chikako Ono, Yoshiharu Matsuura, Yoshiaki Okada, Yasuo Yoshioka, Yasushi Fujio, Masanori Obana

Am J Physiol Renal Physiol　Vol. 326(6)　p. F931-F941　2024/06/01　Research paper (scientific journal)

An inactivated whole-virion vaccine for Enterovirus D68 adjuvanted with CpG ODN or AddaVax elicits potent protective immunity in mice

Kota Senpuku, Chikako Kataoka-Nakamura, Yuta Kunishima, Toshiro Hirai, Yasuo Yoshioka

Vaccine　Vol. 42　No. 9　p. 2463-2474　2024/04　Research paper (scientific journal)

Humoral and cellular immune responses to COVID-19 mRNA vaccines in immunosuppressed liver transplant recipients.

Takuto Nogimori, Yuta Nagatsuka, Shogo Kobayashi, Hirotomo Murakami, Yuji Masuta, Koichiro Suzuki, Yoshito Tomimaru, Takehiro Noda, Hirofumi Akita, Shokichi Takahama, Yasuo Yoshioka, Yuichiro Doki, Hidetoshi Eguchi, Takuya Yamamoto

Communications medicine　Vol. 4　No. 1　p. 30-30　2024/02/26　Research paper (scientific journal)

Adoptively Transferred Myeloid-Derived Suppressor Cells Decrease Influenza A Virus Infection Mortality in a Mouse Model

Zhiqi Xie, Atsushi Kawai, Nobumasa Watanabe, Naoki Okada, Yasuo Yoshioka, Masashi Tachibana

BPB Reports　Vol. 7　No. 2　p. 26-32　2024　Research paper (scientific journal)

Non-glycosylated G protein with CpG ODN provides robust protection against respiratory syncytial virus without inducing eosinophilia

Eigo Kawahara, Takehiko Shibata, Toshiro Hirai, Yasuo Yoshioka

Frontiers in Immunology　Vol. 14　2023/12/19　Research paper (scientific journal)

CpG ODN enhances the efficacy of F protein vaccine against respiratory syncytial virus infection in the upper respiratory tract via CD4+ T cells

Eigo Kawahara, Shinya Yamamoto, Takehiko Shibata, Toshiro Hirai, Yasuo Yoshioka

Biochemical and Biophysical Research Communications　Vol. 686　p. 149143-149143　2023/12　Research paper (scientific journal)

Intranasal immunization with an RBD-hemagglutinin fusion protein harnesses preexisting immunity to enhance antigen-specific responses

Atsushi Kawai, Nagisa Tokunoh, Eigo Kawahara, Shigeyuki Tamiya, Shinya Okamura, Chikako Ono, Jessica Anindita, Hiroki Tanaka, Hidetaka Akita, Sho Yamasaki, Jun Kunisawa, Toru Okamoto, Yoshiharu Matsuura, Toshiro Hirai, Yasuo Yoshioka

Journal of Clinical Investigation　Vol. 133　No. 23　2023/12/01　Research paper (scientific journal)

A nasal vaccine with inactivated whole-virion elicits protective mucosal immunity against SARS-CoV-2 in mice

Nagisa Tokunoh, Shigeyuki Tamiya, Masato Watanabe, Toru Okamoto, Jessica Anindita, Hiroki Tanaka, Chikako Ono, Toshiro Hirai, Hidetaka Akita, Yoshiharu Matsuura, Yasuo Yoshioka

Frontiers in Immunology　Vol. 14　2023/08/31　Research paper (scientific journal)

Upregulation of Robo4 expression by SMAD signaling suppresses vascular permeability and mortality in endotoxemia and COVID-19 models

Maaya Morita, Aki Yoneda, Nagisa Tokunoh, Tatsumi Masaki, Keisuke Shirakura, Mayumi Kinoshita, Rina Hashimoto, Naoya Shigesada, Junya Takahashi, Masashi Tachibana, Shota Tanaka, Masanori Obana, Nobumasa Hino, Masahito Ikawa, Kazutake Tsujikawa, Chikako Ono, Yoshiharu Matsuura, Hiroyasu Kidoya, Nobuyuki Takakura, Yoshiaki Kubota, Takefumi Doi, Kazuo Takayama, Yasuo Yoshioka, Yasushi Fujio, Yoshiaki Okada

Proceedings of the National Academy of Sciences　Vol. 120　No. 3　2023/01/12　Research paper (scientific journal)

Functional changes in cytotoxic CD8+ T-cell cross-reactivity against the SARS-CoV-2 Omicron variant after mRNA vaccination

Takuto Nogimori, Koichiro Suzuki, Yuji Masuta, Ayaka Washizaki, Mika Yagoto, Mami Ikeda, Yuki Katayama, Hidenori Kanda, Minoru Takada, Shohei Minami, Takeshi Kobayashi, Shokichi Takahama, Yasuo Yoshioka, Takuya Yamamoto

Frontiers in Immunology　Vol. 13　2023/01/04　Research paper (scientific journal)

Efficient antigen delivery by dendritic cell-targeting peptide via nucleolin confers superior vaccine effects in mice

Teppei Matsuda, Kazuki Misato, Shigeyuki Tamiya, Yasuhiro Akeda, Ikuhiko Nakase, Etsushi Kuroda, Shokichi Takahama, Motohiro Nonaka, Takuya Yamamoto, Michiko N. Fukuda, Yasuo Yoshioka

iScience　Vol. 25　No. 11　p. 105324-105324　2022/11　Research paper (scientific journal)

Elucidation of the role of nucleolin as a cell surface receptor for nucleic acid-based adjuvants

Satoki Kitagawa, Teppei Matsuda, Ayaka Washizaki, Hirotomo Murakami, Takuya Yamamoto, Yasuo Yoshioka

npj Vaccines　Vol. 7　No. 1　p. 115-115　2022/10/06　Research paper (scientific journal)

SARS-CoV-2 disrupts respiratory vascular barriers by suppressing Claudin-5 expression

Rina Hashimoto, Junya Takahashi, Keisuke Shirakura, Risa Funatsu, Kaori Kosugi, Sayaka Deguchi, Masaki Yamamoto, Yugo Tsunoda, Maaya Morita, Kosuke Muraoka, Masato Tanaka, Tomoaki Kanbara, Shota Tanaka, Shigeyuki Tamiya, Nagisa Tokunoh, Atsushi Kawai, Masahito Ikawa, Chikako Ono, Keisuke Tachibana, Masuo Kondoh, Masanori Obana, Yoshiharu Matsuura, Akihiro Ohsumi, Takeshi Noda, Takuya Yamamoto, Yasuo Yoshioka, Yu-suke Torisawa, Hiroshi Date, Yasushi Fujio, Miki Nagao, Kazuo Takayama, Yoshiaki Okada

Science Advances　Vol. 8　No. 38　2022/09/23　Research paper (scientific journal)

mRNA vaccine induces cytotoxic CD8+ T-cell cross-reactivity against SARS-CoV-2 Omicron variant and regulates COVID-19 severity

Takuto Nogimori, Koichiro Suzuki, Yuji Masuta, Mika Yagoto, Mami Ikeda, Yuki Katayama, Ayaka Washizaki, Hidenori Kanda, Minoru Takada, Shohei Minami, Takeshi Kobayashi, Shokichi Takahama, Yasuo Yoshioka, Takuya Yamamoto

2022/04/11　Research paper (scientific journal)

免疫抑制的な腫瘍内微小環境を有する腫瘍への効果的ながん免疫療法構築に向けた基礎的研究

宗像 理紗, 青枝 大貴, 小山 正平, 小俣 大樹, 丸山 保, 鈴木 悠乃, 萩原 芙美子, 岡田 欣晃, 吉岡 靖雄, 鈴木 亮

日本薬学会年会要旨集　Vol. 142年会　p. 27J-am03　2022/03

Vaccine using community-acquired respiratory distress syndrome toxin as an antigen against Mycoplasma pneumoniae in mice

Eisuke Yoshikawa, Shigeyuki Tamiya, Yuji Inoue, Koichiro Suzuki, Yasuo Yoshioka

Biochemical and Biophysical Research Communications　Vol. 594　p. 81-87　2022/02　Research paper (scientific journal)

Current Status and Prospects of Vaccines based on DDS Technology

Kawai, A., Hirai, T., Yoshioka, Y.

Drug Delivery System　Vol. 37　No. 5　2022　Research paper (scientific journal)

Considerations of CD8+ T Cells for Optimized Vaccine Strategies Against Respiratory Viruses.

Toshiro Hirai, Yasuo Yoshioka

Frontiers in immunology　Vol. 13　p. 918611-918611　2022　Research paper (scientific journal)

Neutrophil-Mediated Lung Injury Both via TLR2-Dependent Production of IL-1α and IL-12 p40, and TLR2-Independent CARDS Toxin after Mycoplasma pneumoniae Infection in Mice

Shigeyuki Tamiya, Eisuke Yoshikawa, Monami Ogura, Etsushi Kuroda, Koichiro Suzuki, Yasuo Yoshioka

Microbiology Spectrum　Vol. 9　No. 3　2021/12/22　Research paper (scientific journal)

Synergistic effect of non-neutralizing antibodies and interferon-γ for cross-protection against influenza

Meito Shibuya, Shigeyuki Tamiya, Atsushi Kawai, Toshiro Hirai, Mark S. Cragg, Yasuo Yoshioka

iScience　Vol. 24　No. 10　2021/09　Research paper (scientific journal)

The potential of neuraminidase as an antigen for nasal vaccines to increase cross-protection against influenza viruses

Atsushi Kawai, Yasuyuki Yamamoto, Takuto Nogimori, Kohei Takeshita, Takuya Yamamoto, Yasuo Yoshioka

Journal of Virology　Vol. 95　No. 20　2021/08/11　Research paper (scientific journal)

Nasal-subcutaneous prime-boost regimen for inactivated whole-virus influenza vaccine efficiently protects mice against both upper and lower respiratory tract infections.

Meito Shibuya, Shigeyuki Tamiya, Atsushi Kawai, Yasuo Yoshioka

Biochemical and biophysical research communications　Vol. 554　p. 166-172　2021/05/21　Research paper (scientific journal)

HDAC inhibitor, MS-275, increases vascular permeability by suppressing Robo4 expression in endothelial cells

Taito Kashio, Keisuke Shirakura, Mayumi Kinoshita, Maaya Morita, Ryosuke Ishiba, Kosuke Muraoka, Tomoaki Kanbara, Masato Tanaka, Risa Funatsu, Nobumasa Hino, Shohei Koyama, Ryo Suzuki, Yasuo Yoshioka, Taiki Aoshi, Takefumi Doi, Yoshiaki Okada

Tissue Barriers　Vol. 9　No. 3　p. 1911195-1911195　2021/05/06　Research paper (scientific journal)

Susceptibility Analysis in Several Mouse Strains Reveals Robust T-Cell Responses After Mycoplasma pneumoniae Infection in DBA/2 Mice

Shigeyuki Tamiya, Eisuke Yoshikawa, Koichiro Suzuki, Yasuo Yoshioka

Frontiers in Cellular and Infection Microbiology　Vol. 10　p. 602453-602453　2021/01/13　Research paper (scientific journal)

Lipid Nanoparticle Acts as a Potential Adjuvant for Influenza Split Vaccine without Inducing Inflammatory Responses

Shirai S, Kawai A, Shibuya M, Munakata L, Omata D, Suzuki R, Yoshioka Y

Vaccines (Basel)　Vol. 8　No. 3　2020/08　Research paper (scientific journal)

Vaccination using inactivated Mycoplasma pneumoniae induces detrimental infiltration of neutrophils after subsequent infection in mice

Tamiya S, Yoshikawa E, Ogura O, Kuroda E, Suzuki K, Yoshioka Y

Vaccine　Vol. 38　No. 32　p. 4979-4987　2020/07　Research paper (scientific journal)

Vaccine effect of recombinant single-chain hemagglutinin protein as an antigen

Kawai A, Yamamoto Y, Yoshioka Y

Heliyon　Vol. 6　No. 6　2020/06　Research paper (scientific journal)

Murine cross-reactive non-neutralizing polyclonal IgG1 antibodies induced by influenza vaccine inhibit the cross-protective effect of IgG2 against heterologous virus in mice

Shibuya M, Aoshi T, Kuroda E, Yoshioka Y

J Virol.　Vol. 94　No. 12　p. 00323-00330　2020/06　Research paper (scientific journal)

Lipid Nanoparticles Potentiate CpG-Oligodeoxynucleotide-Based Vaccine for Influenza Virus

Seiki Shirai, Meito Shibuya, Atsushi Kawai, Shigeyuki Tamiya, Lisa Munakata, Daiki Omata, Ryo Suzuki, Taiki Aoshi, Yasuo Yoshioka

Frontiers in Immunology　Vol. 10　2020/01/09　Research paper (scientific journal)

Ephrin type-A receptor 2 on tumor-derived exosomes enhances angiogenesis through the activation of MAPK signaling.

Yamashita T, Kamada H, Kanasaki S, Nagano K, Inoue M, Higashisaka K, Yoshioka Y, Tsutsumi Y, Tsunoda S

Pharmazie　Vol. 74　No. 10　p. 614-619　2019/11　Research paper (scientific journal)

Lipid nanoparticles of Type-A CpG D35 suppress tumor growth by changing tumor immune-microenvironment and activate CD8 T cells in mice

Lisa Munakata, Yoshihiko Tanimoto, Akio Osa, Jie Meng, Yasunari Haseda, Yujiro Naito, Hirotomo Machiyama, Atsushi Kumanogoh, Daiki Omata, Kazuo Maruyama, Yasuo Yoshioka, Yoshiaki Okada, Shohei Koyama, Ryo Suzuki, Taiki Aoshi

Journal of Controlled Release　Vol. 313　p. 106-119　2019/11　Research paper (scientific journal)

Peptides with the multibasic cleavage site of the hemagglutinin from highly pathogenic influenza viruses act as cell-penetrating via binding to heparan sulfate and neuropilins.

Yamamoto Y, Tamiya S, Shibuya M, Nakase I, Yoshioka Y

Biochem Biophys Res Commun　Vol. 512　No. 3　p. 453-459　2019/05　Research paper (scientific journal)

Autophagy is a new protective mechanism against the cytotoxicity of platinum nanoparticles in human trophoblasts.

Nakashima A, Higashisaka K, Kusabiraki T, Aoki A, Ushijima A, Ono Y, Tsuda S, Shima T, Yoshino O, Nagano K, Yoshioka Y, Tsutsumi Y, Saito S

Sci Rep　Vol. 9　No. 1　p. 5478-5478　2019/04　Research paper (scientific journal)

Neutrophil depletion exacerbates pregnancy complications, including placental damage, induced by silica nanoparticles in mice.

Higashisaka K, Nakashima A, Iwahara Y, Aoki A, Nakayama M, Yanagihara I, Lin Y, Nagano K, Tsunoda S, Saito S, Yoshioka Y, Tsutsumi Y

Front Immunol　Vol. 9　2018/08　Research paper (scientific journal)

Carbonate apatite nanoparticles act as potent vaccine adjuvant delivery vehicles by enhancing cytokine production induced by encapsulated cytosine-phosphate-guanine oligodeoxynucleotides

Hideki Takahashi, Kazuki Misato, Taiki Aoshi, Yasuyuki Yamamoto, Yui Kubota, Xin Wu, Etsushi Kuroda, Ken J. Ishii, Hirofumi Yamamoto, Yasuo Yoshioka

Frontiers in Immunology　Vol. 9　No. APR　2018/04/18　Research paper (scientific journal)

高活性型XCL1/lymphotactinによる抗原特異的メモリーCTLの効率的な誘導

亀井 萌百, 松尾 一彦, 北畑 孝祐, 吉岡 靖雄, 義江 修, 中山 隆志

日本薬学会年会要旨集　Vol. 138年会　No. 3　p. 168-168　2018/03

Intracellular trafficking of particles inside endosomal vesicles is regulated by particle size

Michihiko Aoyama, Yasuo Yoshioka, Yoshiyuki Arai, Haruna Hirai, Rio Ishimoto, Kazuya Nagano, Kazuma Higashisaka, Takeharu Nagai, Yasuo Tsutsumi

JOURNAL OF CONTROLLED RELEASE　Vol. 260　p. 183-193　2017/08　Research paper (scientific journal)

Permeability of skin to silver nanoparticles after epidermal skin barrier disruption in rats

Kuwagata Makiko, Kumagai Fumiaki, Saito Yoshiaki, Higashisaka Kazuma, Yoshioka Yasuo, Tsutsumi Yasuo

Fundamental Toxicological Sciences　Vol. 4　No. 3　p. 109-119　2017/06　Research paper (scientific journal)

Modifying the Surface of Silica Nanoparticles with Amino or Carboxyl Groups Decreases Their Cytotoxicity to Parenchymal Hepatocytes

Takashi Nagano, Kazuya Nagano, Hiromi Nabeshi, Tokuyuki Yoshida, Haruhiko Kamada, Shin-ichi Tsunoda, Jian-Qing Gao, Kazuma Higashisaka, Yasuo Yoshioka, Yasuo Tsutsumi

BIOLOGICAL & PHARMACEUTICAL BULLETIN　Vol. 40　No. 5　p. 726-728　2017/05　Research paper (scientific journal)

Human scavenger receptor A1-mediated inflammatory response to silica particle exposure is size specific

Nobuo Nishijima, Toshiro Hirai, Kazuki Misato, Michihiko Aoyama, Etsushi Kuroda, Ken J. Ishii, Kazuma Higashisaka, Yasuo Yoshioka, Yasuo Tsutsumi

Frontiers in Immunology　Vol. 8　No. 379　2017/04/03　Research paper (scientific journal)

Moesin is activated in cardiomyocytes in experimental autoimmune myocarditis and mediates tissue restoration with protrusion formation

Mitsuhara Yusuke, Miyawaki Akimitsu, Orimoto Aya, Nakayasu Yusuke, Tsunoda Shin-ichi, Obana Masanori, Maeda Makiko, Nakayama Hiroyuki, Yoshioka Yasuo, Tsutsumi Yasuo, Fujio Yasushi

JOURNAL OF PHARMACOLOGICAL SCIENCES　Vol. 133　No. 3　2017/03

Cellular internalization, transcellular transport, and cellular effects of silver nanoparticles in polarized Caco-2 cells following apical or basolateral exposure

Shunji Imai, Yuki Morishita, Tomoyuki Hata, Masuo Kondoh, Kiyohito Yagi, Jian-Qing Gao, Kazuya Nagano, Kazuma Higashisaka, Yasuo Yoshioka, Yasuo Tsutsumi

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 484　No. 3　p. 543-549　2017/03　Research paper (scientific journal)

Identifying a size-specific hazard of silica nanoparticles after intravenous administration and its relationship to the other hazards that have negative correlations with the particle size in mice

Takayuki Handa, Toshiro Hirai, Natsumi Izumi, Shun-ichi Eto, Shin-ichi Tsunoda, Kazuya Nagano, Kazuma Higashisaka, Yasuo Yoshioka, Yasuo Tsutsumi

NANOTECHNOLOGY　Vol. 28　No. 13　2017/02　Research paper (scientific journal)

Hepatotoxicity, nephrotoxicity, and drug/chemical interaction toxicity of platinum nanoparticles in mice

K. Isoda, T. Daibo, K. Yushina, Y. Yoshioka, Y. Tsutsumi, Y. Akimoto, H. Kawakami, Y. Taira, I. Taira, R. Yanoshita, T. Nishimura, I. Ishida

PHARMAZIE　Vol. 72　No. 1　p. 10-16　2017/01　Research paper (scientific journal)

Potential Suppressive Effects of Two C60 Fullerene Derivatives on Acquired Immunity

Toshiro Hirai, Yasuo Yoshioka, Asako Udaka, Eiichiro Uemura, Tomoyuki Ohe, Hisae Aoshima, Jian-Qing Gao, Ken Kokubo, Takumi Oshima, Kazuya Nagano, Kazuma Higashisaka, Tadahiko Mashino, Yasuo Tsutsumi

Nanoscale Research Letters　Vol. 11　No. 1　2016/12/01　Research paper (scientific journal)

Clusterin in the protein corona plays a key role in the stealth effect of nanoparticles against phagocytes

Michihiko Aoyama, Katutomo Hata, Kazuma Higashisaka, Kazuya Nagano, Yasuo Yoshioka, Yasuo Tsutsumi

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 480　No. 4　p. 690-695　2016/11　Research paper (scientific journal)

Distribution of Silver Nanoparticles to Breast Milk and Their Biological Effects on Breast-Fed Offspring Mice

Yuki Morishita, Yasuo Yoshioka, Yuya Takimura, Yuki Shimizu, Yuki Namba, Nao Nojiri, Takuya Ishizaka, Keizo Takao, Fumiyoshi Yamashita, Kazuhiro Takuma, Yukio Ago, Kazuya Nagano, Yohei Mukai, Haruhiko Kamada, Shin-ichi Tsunoda, Shigeru Saito, Toshio Matsuda, Mitsuru Hashida, Tsuyoshi Miyakawa, Kazuma Higashisaka, Yasuo Tsutsumi

ACS NANO　Vol. 10　No. 9　p. 8180-8191　2016/09　Research paper (scientific journal)

Metal nanoparticles in the presence of lipopolysaccharides trigger the onset of metal allergy in mice

Toshiro Hirai, Yasuo Yoshioka, Natsumi Izumi, Ko-ichi Ichihashi, Takayuki Handa, Nobuo Nishijima, Eiichiro Uemura, Ko-ichi Sagami, Hideki Takahashi, Manami Yamaguchi, Kazuya Nagano, Yohei Mukai, Haruhiko Kamada, Shin-ichi Tsunoda, Ken J. Ishii, Kazuma Higashisaka, Yasuo Tsutsumi

NATURE NANOTECHNOLOGY　Vol. 11　No. 9　p. 808-816　2016/09　Research paper (scientific journal)

Moesin is activated in cardiomyocytes in experimental autoimmune myocarditis and mediates cytoskeletal reorganization with protrusion formation

Akimitsu Miyawaki, Yusuke Mitsuhara, Aya Orimoto, Yusuke Nakayasu, Shin-ichi Tsunoda, Masanori Obana, Makiko Maeda, Hiroyuki Nakayama, Yasuo Yoshioka, Yasuo Tsutsumi, Yasushi Fujio

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY　Vol. 311　No. 2　p. H476-H486　2016/08　Research paper (scientific journal)

High-dose cutaneous exposure to mite allergen induces IgG-mediated protection against anaphylaxis

T. Hirai, Y. Yoshioka, H. Takahashi, T. Handa, N. Izumi, T. Mori, E. Uemura, N. Nishijima, K. Sagami, M. Yamaguchi, S. Eto, K. Nagano, H. Kamada, S. Tsunoda, K. J. Ishii, K. Higashisaka, Y. Tsutsumi

CLINICAL AND EXPERIMENTAL ALLERGY　Vol. 46　No. 7　p. 992-1003　2016/07　Research paper (scientific journal)

Relationship between size and surface modification of silica particles and enhancement and suppression of inflammatory cytokine production by lipopolysaccharide- or peptidoglycan-stimulated RAW264.7 macrophages

Eiichiro Uemura, Yasuo Yoshioka, Toshiro Hirai, Takayuki Handa, Kazuya Nagano, Kazuma Higashisaka, Yasuo Tsutsumi

JOURNAL OF NANOPARTICLE RESEARCH　Vol. 18　No. 6　2016/06　Research paper (scientific journal)

Biocompatibility of nanomaterials

Yoshioka Y, Higashisaka K, Tsutsumi Y

Nanomaterials in Pharmacology　2016/01

Elucidation of immunotoxicity of nanoparticles for developing the sustainable nanotechnology

Yoshioka Y, Higashisaka K, Tsutsumi Y

2015/12　Research paper (international conference proceedings)

A Novel Bispecific Antibody against Human CD3 and Ephrin Receptor A10 for Breast Cancer Therapy

Shintaro Taki, Haruhiko Kamada, Masaki Inoue, Kazuya Nagano, Yohei Mukai, Kazuma Higashisaka, Yasuo Yoshioka, Yasuo Tsutsumi, Shin-ichi Tsunoda

PLOS ONE　Vol. 10　No. 12　2015/12　Research paper (scientific journal)

Hydroxylated fullerene: a potential antiinflammatory and antioxidant agent for preventing mouse preterm birth

Tetsu Wakimoto, Kaoru Uchida, Kazuya Mimura, Takeshi Kanagawa, Tzvetozar Roussev Mehandjiev, Hisae Aoshima, Ken Kokubo, Nobuaki Mitsuda, Yasuo Yoshioka, Yasuo Tsutsumi, Tadashi Kimura, Itaru Yanagihara

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY　Vol. 213　No. 5　2015/11　Research paper (scientific journal)

Potential hazards of skin exposure to nanoparticles

Toshiro Hirai, Yasuo Yoshioka, Kazuma Higashisaka, Yasuo Tsutsumi

Biological Effects of Fibrous and Particulate Substances　p. 123-135　2015/10/26　Part of collection (book)

Biodistribution and therapeutic effects of a monoclonal antibody against Eph receptor A10 in a breast cancer xenograft model

Kazuya Nagano, Yuka Maeda, Takuya Yamashita, Yohei Mukai, Haruhiko Kamada, Kazuma Higashisaka, Yasuo Yoshioka, Yasuo Tsutsumi, Shin-ichi Tsunoda

CANCER RESEARCH　Vol. 75　2015/08

Identification and evaluation of metastasis-related proteins, oxysterol binding protein-like 5 and calumenin, in lung tumors

Kazuya Nagano, Sunao Imai, Xiluli Zhao, Takuya Yamashita, Yasuo Yoshioka, Yasuhiro Abe, Yohei Mukai, Haruhiko Kamada, Shinsaku Nakagawa, Yasuo Tsutsumi, Shin-Ichi Tsunoda

International Journal of Oncology　Vol. 47　No. 1　p. 195-203　2015/07/01　Research paper (scientific journal)

脆弱な個体をも対象としたナノ安全科学研究～Sustainable Nanotechnologyを目指して～

吉岡 靖雄, 東阪 和馬, 堤 康央

2015/07　Research paper (other academic)

金属系ナノマテリアルのナノ安全科学研究～Sustainable Nanotechnologyを目指して～

吉岡 靖雄, 東阪 和馬, 堤 康央

2015/07　Research paper (other academic)

Understanding of immunotoxicity of engineered nanomaterials for the sustainable nanotechnology

Yoshioka Y, Tsutsumi Y

2015/06　Research paper (international conference proceedings)

Sustainable Nanotechnologyを目指したナノ安全科学研究

吉岡 靖雄, 東阪 和馬, 堤 康央

2015/06　Research paper (other academic)

Cutaneous exposure to agglomerates of silica nanoparticles and allergen results in IgE-biased immune response and increased sensitivity to anaphylaxis in mice

Toshiro Hirai, Yasuo Yoshioka, Hideki Takahashi, Ko-ichi Ichihashi, Asako Udaka, Takahide Mori, Nobuo Nishijima, Tokuyuki Yoshida, Kazuya Nagano, Haruhiko Kamada, Shin-ichi Tsunoda, Tatsuya Takagi, Ken J. Ishii, Hiromi Nabeshi, Tomoaki Yoshikawa, Kazuma Higashisaka, Yasuo Tsutsumi

PARTICLE AND FIBRE TOXICOLOGY　Vol. 12　No. 1　2015/06　Research paper (scientific journal)

Protein corona changes mediated by surface modification of amorphous silica nanoparticles suppress acute toxicity and activation of intrinsic coagulation cascade in mice

Tokuyuki Yoshida, Yasuo Yoshioka, Yuki Morishita, Michihiko Aoyama, Saeko Tochigi, Toshiro Hirai, Kota Tanaka, Kazuya Nagano, Haruhiko Kamada, Shin-ichi Tsunoda, Hiromi Nabeshi, Tomoaki Yoshikawa, Kazuma Higashisaka, Yasuo Tsutsumi

NANOTECHNOLOGY　Vol. 26　No. 24　2015/06　Research paper (scientific journal)

ナノ粒子曝露に着眼したアレルギー発症要因の理解に向けて

吉岡 靖雄, 堤 康央

2015/05　Research paper (other academic)

Identification and evaluation of metastasis-related proteins, oxysterol binding protein like 5 and calumenin, in lung tumor.

Nagano K, Imai S, Zhao X, Yoshida Y, Yamashita T, Yoshioka Y, Abe Y, Mukai Y, Kamada H, Nakagawa S, Tsutsumi Y, Tsunoda S

Int. J. Oncol.　2015/05　Research paper (scientific journal)

Short-term changes in intracellular ROS localisation after the silver nanoparticles exposure depending on particle size

Akira Onodera, Fumiko Nishiumi, Kisa Kakiguchi, Atsushi Tanaka, Nami Tanabe, Aki Honma, Katsutoshi Yayama, Yasuo Yoshioka, Kumiko Nakahira, Shigenobu Yonemura, Itaru Yanagihara, Yasuo Tsutsumi, Yuichi Kawai

Toxicology Reports　Vol. 2　p. 574-579　2015/01/01　Research paper (scientific journal)

Silica nanoparticle-induced toxicity in mouse lung and liver imaged by electron microscopy

Isoda Katsuhiro, Kondoh Masuo, Yoshioka Yasuo, Tsutsumi Yasuo, Imazawa Takayoshi, Nishimura Tetsuji, Ishida Isao, Yagi Kiyohito

Fundamental Toxicological Sciences　Vol. 2　No. 1　p. 19-23　2015/01　Research paper (scientific journal)

Aminopeptidase P3, a new member of the TNF-TNFR2 signaling complex, induces phosphorylation of JNK1 and JNK2

Masaki Inoue, Haruhiko Kamada, Yasuhiro Abe, Kazuma Higashisaka, Kazuya Nagano, Yohei Mukai, Yasuo Yoshioka, Yasuo Tsutsumi, Shin-Ichi Tsunoda

Journal of Cell Science　Vol. 128　No. 4　p. 656-669　2015　Research paper (scientific journal)

Generation and characterization of a bispecific diabody targeting both EPH receptor A10 and CD3

Haruhiko Kamada, Shintaro Taki, Kazuya Nagano, Masaki Inoue, Daisuke Ando, Yohei Mukai, Kazuma Higashisaka, Yasuo Yoshioka, Yasuo Tsutsumi, Shin-ichi Tsunoda

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 456　No. 4　p. 908-912　2015/01　Research paper (scientific journal)

Evaluation of silica nanoparticle binding to major human blood proteins

Katsutomo Hata, Kazuma Higashisaka, Kazuya Nagano, Yohei Mukai, Haruhiko Kamada, Shin-ichi Tsunoda, Yasuo Yoshioka, Yasuo Tsutsumi

NANOSCALE RESEARCH LETTERS　Vol. 9　2014/12　Research paper (scientific journal)

Size and surface modification of amorphous silica particles determine their effects on the activity of human CYP3A4 in vitro

Shunji Imai, Yasuo Yoshioka, Yuki Morishita, Tokuyuki Yoshida, Miyuki Uji, Kazuya Nagano, Yohei Mukai, Haruhiko Kamada, Shin-ichi Tsunoda, Kazuma Higashisaka, Yasuo Tsutsumi

NANOSCALE RESEARCH LETTERS　Vol. 9　2014/12　Research paper (scientific journal)

Neutrophilia due to silica nanoparticles induces release of double-stranded DNA.

Higashisaka K, Kunieda A, Iwahara Y, Tanaka K, Nagano K, Mukai Y, Kamada H, Tsunoda S, Yoshioka Y, Tsutsumi Y

Journal of Nanomedicine & Nanotechnology.　2014/10　Research paper (scientific journal)

The absorption, distribution, metabolism, and excretion profile of nanoparticles.

Yoshioka Y, Higashisaka K, Tsunoda S, Tsutsumi Y

Engineered Cell Manipulation for Biomedical Application.　2014/09　Research paper (scientific journal)

Intestinal absorption and biological effects of orally administered amorphous silica particles

Tokuyuki Yoshida, Yasuo Yoshioka, Hideki Takahashi, Kazuki Misato, Takahide Mori, Toshiro Hirai, Kazuya Nagano, Yasuhiro Abe, Yohei Mukai, Haruhiko Kamada, Shin-ichi Tsunoda, Hiromi Nabeshi, Tomoaki Yoshikawa, Kazuma Higashisaka, Yasuo Tsutsumi

NANOSCALE RESEARCH LETTERS　Vol. 9　2014/09　Research paper (scientific journal)

Ephrin receptor A10 is a promising drug target potentially useful for breast cancers including triple negative breast cancers

Kazuya Nagano, Yuka Maeda, So-ichiro Kanasaki, Takanobu Watanabe, Takuya Yamashita, Masaki Inoue, Kazuma Higashisaka, Yasuo Yoshioka, Yasuhiro Abe, Yohei Mukai, Haruhiko Kamada, Yasuo Tsutsumi, Shin-ichi Tsunoda

JOURNAL OF CONTROLLED RELEASE　Vol. 189　p. 72-79　2014/09　Research paper (scientific journal)

Eph receptor A10 has a potential as a target for a prostate cancer therapy

Kazuya Nagano, Takuya Yamashita, Masaki Inoue, Kazuma Higashisaka, Yasuo Yoshioka, Yasuhiro Abe, Yohei Mukai, Haruhiko Kamada, Yasuo Tsutsumi, Shin-ichi Tsunoda

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 450　No. 1　p. 545-549　2014/07　Research paper (scientific journal)

Recent Topics on Development of Nanomaterials and Nano-Safety Science Foreword

Yasuo Yoshioka, Yasuo Tsutsumi

YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN　Vol. 134　No. 6　p. 721-722　2014/06

Nano-safety Science for Sustainable Nanotechnology

Yasuo Yoshioka, Yasuo Tsutsumi

YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN　Vol. 134　No. 6　p. 737-742　2014/06

Polyethyleneimine-coating enhances adenoviral transduction of mesenchymal stem cells

Xinglei Yao, Na Zhou, Li Wan, Xiaodong Su, Zhao Sun, Hiroyuki Mizuguchi, Yasuo Yoshioka, Shinsaku Nakagawa, Robert Chunhua Zhao, Jian-Qing Gao

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 447　No. 3　p. 383-387　2014/05　Research paper (scientific journal)

経皮曝露に着目したナノマテリアルの安全性評価

東阪和馬, 吉岡靖雄, 堤 康央

ファームテックジャパン　2014/05

The effects of silica nanoparticles on allergic diseases : For the development of nanomaterials with efficacy and safety

Vol. 61　No. 4　p. 352-356　2014/04

Proteomics approach for searching diagnostic markers of Parkinson's disease.

MISATO Kazuki, MUKAI Yohei, HIGASHISAKA Kazuma, YOSHIOKA Yasuo, NAGANO Kazuya, KAMADA Haruhiko, FUJIO Yasushi, MOCHIZUKI Hideki, TSUNODA Shin-ichi, TSUTSUMI Yasuo

Abstracts for Annual Meeting of Japanese Proteomics Society　Vol. 2014　p. 73-73　2014

Asian Dust Particles Induce Macrophage Inflammatory Responses via Mitogen-Activated Protein Kinase Activation and Reactive Oxygen Species Production

Kazuma Higashisaka, Maho Fujimura, Mayu Taira, Tokuyuki Yoshida, Shin-ichi Tsunoda, Takashi Baba, Nobuyasu Yamaguchi, Hiromi Nabeshi, Tomoaki Yoshikawa, Masao Nasu, Yasuo Yoshioka, Yasuo Tsutsumi

JOURNAL OF IMMUNOLOGY RESEARCH　2014　Research paper (scientific journal)

Expression of Eph receptor A10 is correlated with lymph node metastasis and stage progression in breast cancer patients

Kazuya Nagano, So-ichiro Kanasaki, Takuya Yamashita, Yuka Maeda, Masaki Inoue, Kazuma Higashisaka, Yasuo Yoshioka, Yasuhiro Abe, Yohei Mukai, Haruhiko Kamada, Yasuo Tsutsumi, Shin-ichi Tsunoda

CANCER MEDICINE　Vol. 2　No. 6　p. 972-977　2013/12　Research paper (scientific journal)

Epidermal growth factor receptor localized to exosome membranes as a possible biomarker for lung cancer diagnosis

T. Yamashita, H. Kamada, S. Kanasaki, Y. Maeda, K. Nagano, Y. Abe, M. Inoue, Y. Yoshioka, Y. Tsutsumi, S. Katayama, M. Inoue, Shin-Ichi Tsunoda

Pharmazie　Vol. 68　No. 12　p. 969-973　2013/12　Research paper (scientific journal)

Proteome profiling and detecting method of lung cancer cell-derived exosomes as tumor biomarkers.

Haruhiko Kamada, Takuya Yamashita, Masaki Inoue, Kazuya Nagano, Sumie Katayama, Yohei Mukai, Yasuo Yoshioka, Kazuma Higashisaka, Yasuo Tsutsumi, Shin-ichi Tsunoda

MOLECULAR CANCER THERAPEUTICS　Vol. 12　No. 11　2013/11

Anti-EphA10 monoclonal antibody is a potential therapy against EphA10 positive breast cancer.

Kazuya Nagano, Yuka Maeda, Takuya Yamashita, Masaki Inoue, Yasuhiro Abe, Yohei Mukai, Haruhiko Kamada, Kazuma Higashisaka, Yasuo Yoshioka, Yasuo Tsutsumi, Shin-ichi Tsunoda

MOLECULAR CANCER THERAPEUTICS　Vol. 12　No. 11　2013/11

Liver-specific microRNAs as biomarkers of nanomaterial-induced liver damage

Takashi Nagano, Kazuma Higashisaka, Akiyoshi Kunieda, Yuki Iwahara, Kota Tanaka, Kazuya Nagano, Yasuhiro Abe, Haruhiko Kamada, Shin-ichi Tsunoda, Hiromi Nabeshi, Tomoaki Yoshikawa, Yasuo Yoshioka, Yasuo Tsutsumi

NANOTECHNOLOGY　Vol. 24　No. 40　2013/10　Research paper (scientific journal)

Acute and chronic nephrotoxicity of platinum nanoparticles in mice

Yoshiaki Yamagishi, Akihiro Watari, Yuya Hayata, Xiangru Li, Masuo Kondoh, Yasuo Yoshioka, Yasuo Tsutsumi, Kiyohito Yagi

NANOSCALE RESEARCH LETTERS　Vol. 8　2013/09　Research paper (scientific journal)

Intranasal exposure to amorphous nanosilica particles could activate intrinsic coagulation cascade and platelets in mice

Tokuyuki Yoshida, Yasuo Yoshioka, Saeko Tochigi, Toshiro Hirai, Miyuki Uji, Ko-ichi Ichihashi, Kazuya Nagano, Yasuhiro Abe, Haruhiko Kamada, Shin-ichi Tsunoda, Hiromi Nabeshi, Kazuma Higashisaka, Tomoaki Yoshikawa, Yasuo Tsutsumi

PARTICLE AND FIBRE TOXICOLOGY　Vol. 10　2013/08　Research paper (scientific journal)

経皮吸収性に着目したナノマテリアルの安全性評価研究

東阪和馬, 吉岡靖雄, 堤 康央

コスメテックジャパン　2013/08

Mutants of lymphotoxin-alpha with augmented cytotoxic activity via TNFR1 for use in cancer therapy

Tomohiro Morishige, Yasuo Yoshioka, Shogo Narimatsu, Shinji Ikemizu, Shin-ichi Tsunoda, Yasuo Tsutsumi, Yohei Mukai, Naoki Okada, Shinsaku Nakagawa

CYTOKINE　Vol. 61　No. 2　p. 578-584　2013/02　Research paper (scientific journal)

Resent Topics on Development of Nanomaterials and Nano-Safety Science Foreword

Yasuo Yoshioka, Yasuo Tsutsumi

YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN　Vol. 133　No. 2　p. 149-150　2013/02

Recent Topics about Nano-safety Science and Its Future

Yasuo Yoshioka, Tomoaki Yoshikawa, Hiromi Nabeshi, Yasuo Tsutsumi

YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN　Vol. 133　No. 2　p. 169-174　2013/02

Robo4 is an effective tumor endothelial marker for antibody-drug conjugates based on the rapid isolation of the anti-Robo4 cell-internalizing antibody

Mai Yoshikawa, Yohei Mukai, Yoshiaki Okada, Yuki Tsumori, Shin-Ichi Tsunoda, Yasuo Tsutsumi, William C. Aird, Yasuo Yoshioka, Naoki Okada, Takefumi Doi, Shinsaku Nakagawa

Blood　Vol. 121　No. 14　p. 2804-2813　2013　Research paper (scientific journal)

Biochemical and hematologic effects of polyvinylpyrrolidone-wrapped fullerene C60 after oral administration

K. Yamashita, Y. Yoshioka, H. Pan, M. Taira, T. Ogura, T. Nagano, M. Aoyama, K. Nagano, Y. Abe, H. Kamada, S. I. Tsunoda, H. Aoshima, H. Nabeshi, T. Yoshikawa, Y. Tsutsumi

Pharmazie　Vol. 68　No. 1　p. 54-57　2013/01　Research paper (scientific journal)

安全なナノマテリアルの開発に資するナノ安全科学研究の最前線

永野貴士, 堤 康央, 吉岡靖雄

感染炎症免疫　2012/12

Potential of acute-phase proteins as biomarkers for sub-nano platinum exposure

T. Nagano, Y. Yoshioka, K. Higashisaka, A. Kunieda, K. Hata, K. Nagano, Y. Abe, H. Kamada, S. Tsunoda, H. Nabeshi, T. Yoshikawa, Y. Tsutsumi

PHARMAZIE　Vol. 67　No. 11　p. 958-959　2012/11　Research paper (scientific journal)

Surface modification of amorphous nanosilica particles suppresses nanosilica-induced cytotoxicity, ROS generation, and DNA damage in various mammalian cells

Tokuyuki Yoshida, Yasuo Yoshioka, Keigo Matsuyama, Yasutaro Nakazato, Saeko Tochigi, Toshiro Hirai, Sayuri Kondoh, Kazuya Nagano, Yasuhiro Abe, Haruhiko Kamada, Shin-ichi Tsunoda, Hiromi Nabeshi, Tomoaki Yoshikawa, Yasuo Tsutsumi

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 427　No. 4　p. 748-752　2012/11　Research paper (scientific journal)

The Safety Assessment of Nanomaterials for Development of Nano-cosmetics

Tokuyuki Yoshida, Yasuo Yoshioka, Yasuo Tsutsumi

YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN　Vol. 132　No. 11　p. 1231-1236　2012/11

Amorphous silica nanoparticles enhance cross-presentation in murine dendritic cells

Toshiro Hirai, Yasuo Yoshioka, Hideki Takahashi, Ko-ichi Ichihashi, Tokuyuki Yoshida, Saeko Tochigi, Kazuya Nagano, Yasuhiro Abe, Haruhiko Kamada, Shin-ichi Tsunoda, Hiromi Nabeshi, Tomoaki Yoshikawa, Yasuo Tsutsumi

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 427　No. 3　p. 553-556　2012/10　Research paper (scientific journal)

Hemopexin as biomarkers for analyzing the biological responses associated with exposure to silica nanoparticles

Kazuma Higashisaka, Yasuo Yoshioka, Kohei Yamashita, Yuki Morishita, Huiyan Pan, Toshinobu Ogura, Takashi Nagano, Akiyoshi Kunieda, Kazuya Nagano, Yasuhiro Abe, Haruhiko Kamada, Shin-ichi Tsunoda, Hiromi Nabeshi, Tomoaki Yoshikawa, Yasuo Tsutsumi

NANOSCALE RESEARCH LETTERS　Vol. 7　2012/10　Research paper (scientific journal)

ナノ安全科学研究の最前線

吉岡靖雄, 堤 康央

CICSJ Bulletin　2012/09

Intravenous Administration of Polyethylene Glycol-Coated (PEGylated) Proteins and PEGylated Adenovirus Elicits an Anti-PEG Immunoglobulin M Response

Taro Shimizu, Masako Ichihara, Yasuo Yoshioka, Tatsuhiro Ishida, Shinsaku Nakagawa, Hiroshi Kiwada

BIOLOGICAL & PHARMACEUTICAL BULLETIN　Vol. 35　No. 8　p. 1336-1342　2012/08　Research paper (scientific journal)

Optimization and Internalization Mechanisms of PEGylated Adenovirus Vector with Targeting Peptide for Cancer Gene Therapy

Xing-Lei Yao, Yasuo Yoshioka, Gui-Xin Ruan, Yu-Zhe Chen, Hiroyuki Mizuguchi, Yohei Mukai, Naoki Okada, Jian-Qing Gao, Shinsaku Nakagawa

BIOMACROMOLECULES　Vol. 13　No. 8　p. 2402-2409　2012/08　Research paper (scientific journal)

Amorphous nanosilica particles induce ROS generation in Langerhans cells

T. Yoshida, T. Yoshikawa, H. Nabeshi, K. Matsuyama, T. Hirai, T. Akase, Y. Yoshioka, N. Itoh, Y. Tsutsumi

PHARMAZIE　Vol. 67　No. 8　p. 740-741　2012/08　Research paper (scientific journal)

Dermal absorption of amorphous nanosilica particles after topical exposure for three days

T. Hirai, T. Yoshikawa, H. Nabeshi, T. Yoshida, T. Akase, Y. Yoshioka, N. Itoh, Y. Tsutsumi

PHARMAZIE　Vol. 67　No. 8　p. 742-743　2012/08　Research paper (scientific journal)

Distribution and histologic effects of intravenously administered amorphous nanosilica particles in the testes of mice

Yuki Morishita, Yasuo Yoshioka, Hiroyoshi Satoh, Nao Nojiri, Kazuya Nagano, Yasuhiro Abe, Haruhiko Kamada, Shin-ichi Tsunoda, Hiromi Nabeshi, Tomoaki Yoshikawa, Yasuo Tsutsumi

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 420　No. 2　p. 297-301　2012/04　Research paper (scientific journal)

Annexin A4 is a possible biomarker for cisplatin susceptibility of malignant mesothelioma cells

Takuya Yamashita, Kazuya Nagano, So-ichiro Kanasaki, Yuka Maeda, Takeshi Furuya, Masaki Inoue, Hiromi Nabeshi, Tomoaki Yoshikawa, Yasuo Yoshioka, Norio Itoh, Yasuhiro Abe, Haruhiko Kamada, Yasuo Tsutsumi, Shin-ichi Tsunoda

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 421　No. 1　p. 140-144　2012/04　Research paper (scientific journal)

ナノカーボンDDSの現状とその安全性確保に向けて

平井敏郎, 吉岡靖雄, 堤 康央

ドラッグデリバリーシステムの新展開Ⅱ -核酸医薬・抗体医薬・ワクチン医療を支えるDDS技術-　2012/03

Suppression of nanosilica particle–induced inflammation by surface modification of the particles

Morishige T, Yoshioka Y, Inakura H, Tanabe A, Narimatsu S, Yao X, Monobe Y, Imazawa T, Tsunoda S, Tsutsumi Y, Mukai Y, Okada N, Nakagawa S

Arch. Toxicol　2012/03　Research paper (scientific journal)

Rho GDP-dissociation inhibitor alpha is associated with cancer metastasis in colon and prostate cancer

T. Yamashita, T. Okamura, K. Nagano, S. Imai, Y. Abe, H. Nabeshi, T. Yoshikawa, Y. Yoshioka, H. Kamada, Y. Tsutsumi, S. Tsunoda

PHARMAZIE　Vol. 67　No. 3　p. 253-255　2012/03　Research paper (scientific journal)

The Safety Assessment of Nanomaterials in Reproductive Developmental Field

Kohei Yamashita, Yasuo Yoshioka

YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN　Vol. 132　No. 3　p. 331-335　2012/03　Research paper (scientific journal)

Carbon Nanomaterials: Efficacy and Safety for Nanomedicine

Takuya Yamashita, Kohei Yamashita, Hiromi Nabeshi, Tomoaki Yoshikawa, Yasuo Yoshioka, Shin-ichi Tsunoda, Yasuo Tsutsumi

MATERIALS　Vol. 5　No. 2　p. 350-363　2012/02

Amorphous silica nanoparticles size-dependently aggravate atopic dermatitis-like skin lesions following an intradermal injection

Toshiro Hirai, Tomoaki Yoshikawa, Hiromi Nabeshi, Tokuyuki Yoshida, Saeko Tochigi, Ko-ichi Ichihashi, Miyuki Uji, Takanori Akase, Kazuya Nagano, Yasuhiro Abe, Haruhiko Kamada, Norio Itoh, Shin-ichi Tsunoda, Yasuo Yoshioka, Yasuo Tsutsumi

PARTICLE AND FIBRE TOXICOLOGY　Vol. 9　2012/02　Research paper (scientific journal)

Amorphous nanosilicas induce consumptive coagulopathy after systemic exposure

Hiromi Nabeshi, Tomoaki Yoshikawa, Keigo Matsuyama, Yasutaro Nakazato, Akihiro Arimori, Masaaki Isobe, Saeko Tochigi, Sayuri Kondoh, Toshiro Hirai, Takanori Akase, Takuya Yamashita, Kohei Yamashita, Tokuyuki Yoshida, Kazuya Nagano, Yasuhiro Abe, Yasuo Yoshioka, Haruhiko Kamada, Takayoshi Imazawa, Norio Itoh, Masuo Kondoh, Kiyohito Yagi, Tadanori Mayumi, Shin-ichi Tsunoda, Yasuo Tsutsumi

NANOTECHNOLOGY　Vol. 23　No. 4　2012/02　Research paper (scientific journal)

Safety design of nanoparticle based-vaccine using protein corona

UDAKA Asako, YOSHIOKA Yasuo, YOSHIDA Tokuyuki, UJI Miyuki, MISATO Kazuki, MORI Takahide, HIRAI Toshiro, NAGANO Kazuya, ABE Yasuhiro, KAMADA Haruhiko, TSUNODA Shin-ichi, NABESHI Hiromi, YOSHIKAWA Tomoaki, TSUTSUMI Yasuo

Annual Meeting of the Japanese Society of Toxicology　Vol. 39　p. O-39　2012

Safety evaluation of food nanomaterials based on intestinal flora variation

MORI Takahide, YOSHIOKA Yasuo, YOSHIDA Tokuyuki, UJI Miyuki, MISATO Kazuki, UDAKA Asako, HIRAI Toshiro, TSUNODA Shin-ichi, NABESHI Hiromi, YOSHIKAWA Tomoaki, TSUTSUMI Yasuo

Annual Meeting of the Japanese Society of Toxicology　Vol. 39　p. O-37　2012

Analysis of amorphous nanosilica particles-mediated blood coagulation

YOSHIDA Tokuyuki, YOSHIOKA Yasuo, TOCHIGI Saeko, UJI Miyuki, MISATO Kazuki, UDAKA Asako, MORI Takahide, HIRAI Toshiro, TSUNODA Shin-ichi, NABESHI Hiromi, YOSHIKAWA Tomoaki, TSUTSUMI Yasuo

Annual Meeting of the Japanese Society of Toxicology　Vol. 39　p. O-30　2012

The basic safety assessment of fullerenol by oral administration for the development of safe nanomedicine

YAMASHITA Kohei, YOSHIOKA Yasuo, PAN Huiyan, OGURA Toshinobu, TAIRA Mayu, AOYAMA Michihiko, TSUNODA Shin-ichi, NAKAYAMA Hiroyuki, FUJIO Shigeru, AOSHIMA Hisae, KOKUBO Ken, OSHIMA Takumi, NABESHI Hiromi, YOSHIKAWA Tomoaki, TSUTSUMI Yasuo

Annual Meeting of the Japanese Society of Toxicology　Vol. 39　p. O-36　2012

Association between neutrophilia and inflammatory responses for ensuring safety of nanomaterials

HIGASHISAKA Kazuma, YOSHIOKA Yasuo, NAGANO Takashi, KUNIEDA Akiyoshi, HATA Katsutomo, TSUNODA Shin-ichi, NABESHI Hiromi, YOSHIKAWA Tomoaki, TSUTSUMI Yasuo

Annual Meeting of the Japanese Society of Toxicology　Vol. 39　p. O-23　2012

Assessment of the microRNA-122 as a biomarker toward the developing of safety nanomaterials

NAGANO Takashi, YOSHIOKA Yasuo, HIGASHISAKA Kazuma, KUNIEDA Akiyoshi, HATA Katsutomo, TSUNODA Shin-ichi, NABESHI Hiromi, YOSHIKAWA Tomoaki, TSUTSUMI Yasuo

Annual Meeting of the Japanese Society of Toxicology　Vol. 39　p. O-38　2012

Hazard identification of nano and sub-nano silver following nasal exposure

ICHIHASHI Ko-ichi, YOSHIOKA Yasuo, HIRAI Toshiro, TAKAHASHI Hideki, YOSHIDA Tokuyuki, TSUNODA Shin-ichi, NABESHI Hiromi, YOSHIKAWA Tomoaki, TSUTSUMI Yasuo

Annual Meeting of the Japanese Society of Toxicology　Vol. 39　p. O-26　2012

Safety evaluation of sublingually administered nanomaterials and sub-nanomaterials

MISATO Kazuki, YOSHIOKA Yasuo, YOSHIDA Tokuyuki, UJI Miyuki, UDAKA Asako, MORI Takahide, HIRAI Toshiro, AKASE Takanori, TSUNODA Shin-ichi, NABESHI Hiromi, YOSHIKAWA Tomoaki, TSUTSUMI Yasuo

Annual Meeting of the Japanese Society of Toxicology　Vol. 39　p. O-27　2012

Sub-nano materials might cause pregnancy complications in mice

SATO Hiroyoshi, YOSHIOKA Yasuo, MORISHITA Yuki, NOJIRI Nao, TSUNODA Shin-ichi, NABESHI Hiromi, YOSHIKAWA Tomoaki, TSUTSUMI Yasuo

Annual Meeting of the Japanese Society of Toxicology　Vol. 39　p. O-28　2012

Dermal toxicity of subnano/nano-titanium in rats

KUWAGATA Makiko, MATSUMOTO Aki, KUMAGAI Fumiaki, SAITO Yoshiaki, MARUMO Hideki, NOGUCHI Satoshi, USUMI Kenji, CHISAKA Akiko, FURUYA Mami, SEKI Takayuki, KATOH Hiroyasu, TAKASHIMA Hiromasa, YOSHIDA Tokuyuki, YOSHIKAWA Tomoaki, YOSHIOKA Yasuo, TSUTSUMI Yasuo

Annual Meeting of the Japanese Society of Toxicology　Vol. 39　p. P-140　2012

Hazard identification of exposure to nanomaterial in lactation period

YOSHIOKA Yasuo, NOJIRI Nao, MORISHITA Yuki, SATOH Hiroyoshi, TSUNODA Shin-ichi, NABESHI Hiromi, YOSHIKAWA Tomoaki, TSUTSUMI Yasuo

Annual Meeting of the Japanese Society of Toxicology　Vol. 39　p. P-138　2012

Nanosilica-mediated enhancement of MHC class I-restricted cross-presentation

TAKAHASHI Hideki, YOSHIOKA Yasuo, HIRAI Toshiro, ICHIHASHI Ko-ichi, YOSHIDA Tokuyuki, TSUNODA Shin-ichi, NABESHI Hiromi, YOSHIKAWA Tomoaki, TSUTSUMI Yasuo

Annual Meeting of the Japanese Society of Toxicology　Vol. 39　p. P-137　2012

The hazard identification of amorphous nanosilica particles following dermal applications using the atopic dermatitis model mouse

HIRAI Toshiro, YOSHIOKA Yasuo, ICHIHASHI Ko-ichi, TAKAHASHI Hideki, YOSHIDA Tokuyuki, TAKAGI Tatsuya, TSUNODA Shin-ichi, NABESHI Hiromi, YOSHIKAWA Tomoaki, TSUTSUMI Yasuo

Annual Meeting of the Japanese Society of Toxicology　Vol. 39　p. P-136　2012

Intestinal absorption of amorphous nanosilica particles

UJI Miyuki, YOSHIOKA Yasuo, YOSHIDA Tokuyuki, MISATO Kazuki, UDAKA Asako, MORI Takahide, HIRAI Toshiro, TSUNODA Shin-ichi, NABESHI Hiromi, YOSHIKAWA Tomoaki, TSUTSUMI Yasuo

Annual Meeting of the Japanese Society of Toxicology　Vol. 39　p. P-134　2012

Identification of new biomarkers for lung cancer by exploring proteins derived from exosomes

Kamada Haruhiko, Yamashita Takuya, Nagano Kazuya, Maeda Yuka, Abe Yasuhiro, Yoshikawa Tomoaki, Yoshioka Yasuo, Tsutsumi Yasuo, Tsunoda Shin-ichi

Abstracts for Annual Meeting of Japanese Proteomics Society　Vol. 2012　p. 145-145　2012

ナノカーボンDDSの可能性と安全性

平井敏郎, 吉岡靖雄, 堤 康央

『ドラッグデリバリーシステムの新展開? -核酸医薬・抗体医薬・ワクチン医療を支えるDDS技術-』　2011/12

Induction of Endoplasmic Reticulum-Endosome Fusion for Antigen Cross-Presentation Induced by Poly (gamma-Glutamic Acid) Nanoparticles

Yohei Mukai, Tomoyo Yoshinaga, Mai Yoshikawa, Kazuhiko Matsuo, Tomoaki Yoshikawa, Keisuke Matsuo, Kazuyuki Niki, Yasuo Yoshioka, Naoki Okada, Shinsaku Nakagawa

JOURNAL OF IMMUNOLOGY　Vol. 187　No. 12　p. 6249-6255　2011/12　Research paper (scientific journal)

Lysine-deficient lymphotoxin-alpha mutant for site-specific PEGylation

Shogo Narimatsu, Yasuo Yoshioka, Hikaru Watanabe, Takashi Masano, Tomohiro Morishige, Xinglei Yao, Aya Tanabe, Shin-ichi Tsunoda, Yasuo Tsutsumi, Yohei Mukai, Naoki Okada, Shinsaku Nakagawa

CYTOKINE　Vol. 56　No. 2　p. 489-493　2011/11　Research paper (scientific journal)

Biological and structural characterization of human TNFR2-selective TNF mutants

Yasuhiro Abe, Masaki Inoue, Takeshi Furuya, Yohei Mukai, Teruya Nakamura, Yuriko Yamagata, Hiromi Nabeshi, Tomoaki Yoshikawa, Yasuo Yoshioka, Kazuya Nagano, Haruhiko Kamada, Yasuo Tsutsumi, Shin-ichi Tsunoda

CYTOKINE　Vol. 56　No. 1　p. 78-78　2011/10

Creation of mouse TNFR2-selective TNF mutant using phage display system

Takeshi Furuya, Yasuhiro Abe, Masaki Inoue, Hiromi Nabeshi, Tomoaki Yoshikawa, Yasuo Yoshioka, Norio Itoh, Kazuya Nagano, Haruhiko Kamada, Yasuo Tsutsumi, Shin-ichi Tsunoda

CYTOKINE　Vol. 56　No. 1　p. 90-90　2011/10

Structure-activity relationship of T-cell receptors based on alanine scanning.

Narimatsu S, Yoshioka Y, Morishige T, Yao X, Tsunoda S, Tsutsumi Y, Nishimura MI, Mukai Y, Okada N, Nakagawa S

Biochem. Biophys. Res. Commun　2011/10　Research paper (scientific journal)

Detection of titanium dioxide particles on frozen tissue sections using synchrotron radiation X-ray fluorescence analysis

Y. Morishita, K. Yamashita, T. Yoshikawa, Y. Terada, H. Nabeshi, Y. Yoshioka, N. Itoh, Y. Tsutsumi

PHARMAZIE　Vol. 66　No. 10　p. 808-809　2011/10　Research paper (scientific journal)

Tumor Vascular Targeted Delivery of Polymer-conjugated Adenovirus Vector for Cancer Gene Therapy

Xinglei Yao, Yasuo Yoshioka, Tomohiro Morishige, Yusuke Eto, Shogo Narimatsu, Yasuaki Kawai, Hiroyuki Mizuguchi, Jian-Qing Gao, Yohei Mukai, Naoki Okada, Shinsaku Nakagawa

MOLECULAR THERAPY　Vol. 19　No. 9　p. 1619-1625　2011/09　Research paper (scientific journal)

Size-dependent immune-modulating effect of amorphous nanosilica particles

T. Hirai, T. Yoshikawa, H. Nabeshi, T. Yoshida, S. Tochigi, M. Uji, K. Ichihashi, T. Akase, T. Yamashita, K. Yamashita, K. Nagano, Y. Abe, H. Kamada, S. Tsunoda, Y. Yoshioka, N. Itoh, Y. Tsutsumi

PHARMAZIE　Vol. 66　No. 9　p. 727-728　2011/09　Research paper (scientific journal)

Fine tuning of receptor-selectivity for tumor necrosis factor-alpha using a phage display system with one-step competitive panning

Yasuhiro Abe, Tomoaki Yoshikawa, Masaki Inoue, Tetsuya Nomura, Takeshi Furuya, Takuya Yamashita, Kazuya Nagano, Hiromi Nabeshi, Yasuo Yoshioka, Yohei Mukai, Shinsaku Nakagawa, Haruhiko Kamada, Yasuo Tsutsumi, Shin-ichi Tsunoda

BIOMATERIALS　Vol. 32　No. 23　p. 5498-5504　2011/08　Research paper (scientific journal)

Effect of amorphous silica nanoparticles on in vitro RANKL-induced osteoclast differentiation in murine macrophages

Hiromi Nabeshi, Tomoaki Yoshikawa, Takanori Akase, Tokuyuki Yoshida, Saeko Tochigi, Toshiro Hirai, Miyuki Uji, Ko-ichi Ichihashi, Takuya Yamashita, Kazuma Higashisaka, Yuki Morishita, Kazuya Nagano, Yasuhiro Abe, Haruhiko Kamada, Shin-ichi Tsunoda, Norio Itoh, Yasuo Yoshioka, Yasuo Tsutsumi

NANOSCALE RESEARCH LETTERS　Vol. 6　2011/07　Research paper (scientific journal)

Modifying the antigen-immunization schedule improves the variety of monoclonal antibodies obtained from immune-phage antibody libraries against HIV-1 Nef and Vif

Mai Yoshikawa, Yohei Mukai, Shin-Ichi Tsunoda, Yasuo Tsutsumi, Yasuo Yoshioka, Naoki Okada, Shinsaku Nakagawa

Journal of Bioscience and Bioengineering　Vol. 111　No. 5　p. 597-599　2011/05　Research paper (scientific journal)

Amorphous nanosilica induce endocytosis-dependent ROS generation and DNA damage in human keratinocytes.

Nabeshi H, Yoshikawa T, Matsuyama K, Nakazato Y, Tochigi S, Kondoh S, Hirai T, Akase T, Yamashita T, Yamashita K, Yoshida T, Nagano K, Abe Y, Yoshioka Y, Kamada H, Imazawa T, Itoh N, Tsunoda S, Tsutsumi Y

Part. Fibre. Toxicol.　2011/03　Research paper (scientific journal)

Limited expression of reticulocalbin-1 in lymphatic endothelial cells in lung tumor but not in normal lung

Yasunobu Yoshida, Takuya Yamashita, Kazuya Nagano, Sunao Imai, Hiromi Nabeshi, Tomoaki Yoshikawa, Yasuo Yoshioka, Yasuhiro Abe, Haruhiko Kamada, Yasuo Tsutsumi, Shin-ichi Tsunoda

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 405　No. 4　p. 610-614　2011/02　Research paper (scientific journal)

Anti-inflammatory Effects of a Novel TNFR1-Selective Antagonistic TNF Mutant on Established Murine Collagen-Induced Arthritis

Yasuhiro Abe, Tetsuya Nomura, Yasuo Yoshioka, Haruhiko Kamada, Shin-ichi Tsunoda, Yasuo Tsutsumi

ADVANCES IN TNF FAMILY RESEARCH　Vol. 691　p. 493-500　2011　Research paper (scientific journal)

CREATION OF MUTANT LYMPHOTOXIN-ALPHAS WITH ENHANCED BIOACTIVITIES BY PHAGE DISPLAY TECHNIQUE

Yasuo Yoshioka, Hikaru Watanabe, Yasuo Tsutsumi, Yohei Mukai, Naoki Okada, Shinsaku Nakagawa

ADVANCES IN TNF FAMILY RESEARCH　Vol. 691　p. 720-720　2011

RECEPTOR INTERACTION OF TUMOR NECROSIS FACTOR (TNF) BASED ON 3D STRUCTURAL ANALYSIS OF A FULLY ACTIVE TNFR1-SELECTIVE TNF MUTANT

Yohei Mukai, Teruya Nakamura, Yasuo Yoshioka, Yasuhiro Abe, Tetsuya Nomura, Madoka Taniai, Tsunetaka Ohta, Shinji Ikemizu, Shinsaku Nakagawa, Shin-ichi Tsunoda, Haruhiko Kamada, Yuriko Yamagata, Yasuo Tsutsumi

ADVANCES IN TNF FAMILY RESEARCH　Vol. 691　p. 804-804　2011

THE DEVELOPMENT OF FULLY ACTIVE RECEPTOR-SELECTIVE TUMOR NECROSIS FACTOR (TNF) MUTANTS

Mai Yoshikawa, Yohei Mukai, Hiroko Shibata, Yasuo Yoshioka, Yasuhiro Abe, Tetsuya Nomura, Madoka Taniai, Tsunetaka Ohta, Shin-ichi Tsunoda, Haruhiko Kamada, Shinsaku Nakagawa, Yasuo Tsutsumi

ADVANCES IN TNF FAMILY RESEARCH　Vol. 691　p. 805-805　2011

Silica and titanium dioxide nanoparticles cause pregnancy complications in mice

Kohei Yamashita, Yasuo Yoshioka, Kazuma Higashisaka, Kazuya Mimura, Yuki Morishita, Masatoshi Nozaki, Tokuyuki Yoshida, Toshinobu Ogura, Hiromi Nabeshi, Kazuya Nagano, Yasuhiro Abe, Haruhiko Kamada, Youko Monobe, Takayoshi Imazawa, Hisae Aoshima, Kiyoshi Shishido, Yuichi Kawai, Tadanori Mayumi, Shin-Ichi Tsunoda, Norio Itoh, Tomoaki Yoshikawa, Itaru Yanagihara, Shigeru Saito, Yasuo Tsutsumi

Nature Nanotechnology　Vol. 6　No. 5　p. 321-328　2011　Research paper (scientific journal)

Promotion of allergic immune responses by intranasally-administrated nanosilica particles in mice

Tokuyuki Yoshida, Yasuo Yoshioka, Maho Fujimura, Kohei Yamashita, Kazuma Higashisaka, Yuki Morishita, Hiroyuki Kayamuro, Hiromi Nabeshi, Kazuya Nagano, Yasuhiro Abe, Haruhiko Kamada, Shin-ichi Tsunoda, Norio Itoh, Tomoaki Yoshikawa, Yasuo Tsutsumi

NANOSCALE RESEARCH LETTERS　Vol. 6　2011　Research paper (scientific journal)

Effect of surface properties of silica nanoparticles on their cytotoxicity and cellular distribution in murine macrophages

Hiromi Nabeshi, Tomoaki Yoshikawa, Akihiro Arimori, Tokuyuki Yoshida, Saeko Tochigi, Toshiro Hirai, Takanori Akase, Kazuya Nagano, Yasuhiro Abe, Haruhiko Kamada, Shin-ichi Tsunoda, Norio Itoh, Yasuo Yoshioka, Yasuo Tsutsumi

NANOSCALE RESEARCH LETTERS　Vol. 6　2011　Research paper (scientific journal)

Development of an antibody proteomics system using a phage antibody library for efficient screening of biomarker proteins

Sunao Imai, Kazuya Nagano, Yasunobu Yoshida, Takayuki Okamura, Takuya Yamashita, Yasuhiro Abe, Tomoaki Yoshikawa, Yasuo Yoshioka, Haruhiko Kamada, Yohei Mukai, Shinsaku Nakagawa, Yasuo Tsutsumi, Shin-ichi Tsunoda

BIOMATERIALS　Vol. 32　No. 1　p. 162-169　2011/01　Research paper (scientific journal)

Systemic distribution, nuclear entry and cytotoxicity of amorphous nanosilica following topical application.

Nabeshi H, Yoshikawa T, Matsuyama K, Nakazato Y, Matsuo K, Arimori A, Isobe M, Tochigi S, Kondoh S, Hirai T, Akase T, Yamashita T, Yamashita K, Yoshida T, Nagano K, Abe Y, Yoshioka Y, Kamada H, Imazawa T, Nakagawa S, Mayumi T, Itoh N, Tsunoda S, Tsutsumi Y

Biomaterials　2011/01　Research paper (scientific journal)

Acute phase proteins as biomarkers for predicting the exposure and toxicity of nanomaterials

Kazuma Higashisaka, Yasuo Yoshioka, Kohei Yamashita, Yuki Morishita, Maho Fujimura, Hiromi Nabeshi, Kazuya Nagano, Yasuhiro Abe, Haruhiko Kamada, Shin-ichi Tsunoda, Tomoaki Yoshikawa, Norio Itoh, Yasuo Tsutsumi

BIOMATERIALS　Vol. 32　No. 1　p. 3-9　2011/01　Research paper (scientific journal)

Therapeutic effect of PEGylated TNFR1-selective antagonistic mutant TNF in experimental autoimmune encephalomyelitis mice

Tetsuya Nomura, Yasuhiro Abe, Haruhiko Kamada, Hiroko Shibata, Hiroyuki Kayamuro, Masaki Inoue, Tomoyuki Kawara, Shuhei Arita, Takeshi Furuya, Takuya Yamashita, Kazuya Nagano, Tomoaki Yoshikawa, Yasuo Yoshioka, Yohei Mukai, Shinsaku Nakagawa, Madoka Taniai, Tsunetaka Ohta, Satoshi Serada, Tetsuji Naka, Shin-ichi Tsunoda, Yasuo Tsutsumi

JOURNAL OF CONTROLLED RELEASE　Vol. 149　No. 1　p. 8-14　2011/01　Research paper (scientific journal)

Transcutaneous vaccination using a hydrogel patch induces effective immune responses to tetanus and diphtheria toxoid in hairless rat

Kazuhiko Matsuo, Yumiko Ishii, Ying-Shu Quan, Fumio Kamiyama, Yohei Mukai, Yasuo Yoshioka, Naoki Okada, Shinsaku Nakagawa

JOURNAL OF CONTROLLED RELEASE　Vol. 149　No. 1　p. 15-20　2011/01　Research paper (scientific journal)

The Utility of Poly(gamma-glutamic acid) Nanoparticles as Antigen Delivery Carriers in Dendritic Cell-Based Cancer Immunotherapy

Keisuke Matsuo, Yumiko Ishii, Kazuhiko Matsuo, Tomoyo Yoshinaga, Mitsuru Akashi, Yohei Mukai, Yasuo Yoshioka, Naoki Okada, Shinsaku Nakagawa

BIOLOGICAL & PHARMACEUTICAL BULLETIN　Vol. 33　No. 12　p. 2003-2007　2010/12　Research paper (scientific journal)

Interleukin-1 Family Cytokines as Mucosal Vaccine Adjuvants for Induction of Protective Immunity against Influenza Virus

Hiroyuki Kayamuro, Yasuo Yoshioka, Yasuhiro Abe, Shuhei Arita, Kazufumi Katayama, Tetsuya Nomura, Tomoaki Yoshikawa, Ritsuko Kubota-Koketsu, Kazuyoshi Ikuta, Shigefumi Okamoto, Yasuko Mori, Jun Kunisawa, Hiroshi Kiyono, Norio Itoh, Kazuya Nagano, Haruhiko Kamada, Yasuo Tsutsumi, Shin-Ichi Tsunoda

JOURNAL OF VIROLOGY　Vol. 84　No. 24　p. 12703-12712　2010/12　Research paper (scientific journal)

Potential adjuvant effect of intranasal urban aerosols in mice through induction of dendritic cell maturation

Tokuyuki Yoshida, Yasuo Yoshioka, Maho Fujimura, Kohei Yamashita, Kazuma Higashisaka, Ryosuke Nakanishi, Yuki Morishita, Hiroyuki Kayamuro, Hiromi Nabeshi, Kazuya Nagano, Yasuhiro Abe, Haruhiko Kamada, Shinichi Tsunoda, Tomoaki Yoshikawa, Norio Itoh, Yasuo Tsutsumi

TOXICOLOGY LETTERS　Vol. 199　No. 3　p. 383-388　2010/12　Research paper (scientific journal)

Anti-inflammatory effects of a novel TNFR1-selective antagonistic TNF mutant in murine experimental autoimmune encephalomyelitis

Yasuhiro Abe, Tetsuya Nomura, Masaki Inoue, Shu-hei Arita, Takeshi Furuya, Tomoaki Yoshikawa, Yasuo Yoshioka, Kazuya Nagano, Haruhiko Kamada, Yasuo Tsutsumi, Shin-ichi Tsunoda

CYTOKINE　Vol. 52　No. 1-2　p. 45-45　2010/10

The potential use of IL-1 family cytokines as mucosal adjuvants for a NASA influenza vaccine

Shu-hei Arita, Hiroyuki Kayamuro, Yasuhiro Abe, Yasuo Yoshioka, Haruhiko Kamada, Tsuyoshi Furuya, Norio Itoh, Tomoaki Yoshikawa, Kazuya Nagano, Yasuo Tsutsumi, Shin-ichi Tsunoda

CYTOKINE　Vol. 52　No. 1-2　p. 89-90　2010/10

Optimized PEGylated Adenovirus Vector Reduces the Anti-vector Humoral Immune Response against Adenovirus and Induces a Therapeutic Effect against Metastatic Lung Cancer

Yusuke Eto, Yasuo Yoshioka, Tatsuhiro Ishida, Xinglei Yao, Tomohiro Morishige, Shogo Narimatsu, Hiroyuki Mizuguchi, Yohei Mukai, Naoki Okada, Hiroshi Kiwada, Shinsaku Nakagawa

BIOLOGICAL & PHARMACEUTICAL BULLETIN　Vol. 33　No. 9　p. 1540-1544　2010/09　Research paper (scientific journal)

The effect of surface modification of amorphous silica particles on NLRP3 inflammasome mediated IL-1 beta production, ROS production and endosomal rupture

Tomohiro Morishige, Yasuo Yoshioka, Hiroshi Inakura, Aya Tanabe, Xinglei Yao, Shogo Narimatsu, Youko Monobe, Takayoshi Imazawa, Shin-ichi Tsunoda, Yasuo Tsutsumi, Yohei Mukai, Naoki Okada, Shinsaku Nakagawa

BIOMATERIALS　Vol. 31　No. 26　p. 6833-6842　2010/09　Research paper (scientific journal)

Cytotoxicity of amorphous silica particles against macrophage-like THP-1 cells depends on particle-size and surface properties

T. Morishige, Y. Yoshioka, H. Inakura, A. Tanabe, X. Yao, S. Tsunoda, Y. Tsutsumi, Y. Mukai, N. Okada, S. Nakagawa

PHARMAZIE　Vol. 65　No. 8　p. 596-599　2010/08　Research paper (scientific journal)

Carbon Nanotubes Elicit DNA Damage and Inflammatory Response Relative to Their Size and Shape

Kohei Yamashita, Yasuo Yoshioka, Kazuma Higashisaka, Yuki Morishita, Tokuyuki Yoshida, Maho Fujimura, Hiroyuki Kayamuro, Hiromi Nabeshi, Takuya Yamashita, Kazuya Nagano, Yasuhiro Abe, Haruhiko Kamada, Yuichi Kawai, Tadanori Mayumi, Tomoaki Yoshikawa, Norio Itoh, Shin-ichi Tsunoda, Yasuo Tsutsumi

INFLAMMATION　Vol. 33　No. 4　p. 276-280　2010/08　Research paper (scientific journal)

Adenovirus Vector Covalently Conjugated to Polyethylene Glycol with a Cancer-Specific Promoter Suppresses the Tumor Growth through Systemic Administration

Xinglei Yao, Yasuo Yoshioka, Tomohiro Morishige, Yusuke Eto, Shogo Narimatsu, Hiroyuki Mizugguchi, Yohei Mukai, Naoki Okada, Shinsaku Nakagawa

BIOLOGICAL & PHARMACEUTICAL BULLETIN　Vol. 33　No. 6　p. 1073-1076　2010/06　Research paper (scientific journal)

Simple PEG Conjugation of SPIO via an Au-S Bond Improves Its Tumor Targeting Potency as a Novel MR Tumor Imaging Agent

Hiroki Kojima, Yohei Mukai, Mai Yoshikawa, Kazumasa Kamei, Tomoaki Yoshikawa, Masahito Morita, Toshiro Inubushi, Takao A. Yamamoto, Yasuo Yoshioka, Naoki Okada, Satoshi Seino, Shinsaku Nakagawa

BIOCONJUGATE CHEMISTRY　Vol. 21　No. 6　p. 1026-1031　2010/06　Research paper (scientific journal)

Urban Aerosols Induce Pro-inflammatory Cytokine Production in Macrophages and Cause Airway Inflammation in Vivo

Tokuyuki Yoshida, Yasuo Yoshioka, Maho Fujimura, Hiroyuki Kayamuro, Kohei Yamashita, Kazuma Higashisaka, Ryosuke Nakanishi, Yuki Morishita, Hiromi Nabeshi, Takuya Yamashita, Masashi Muroi, Kenichi Tanamoto, Kazuya Nagano, Yasuhiro Abe, Haruhiko Kamada, Yuichi Kawai, Tadanori Mayumi, Norio Itoh, Tomoaki Yoshikawa, Shinichi Tsunoda, Yasuo Tsutsumi

BIOLOGICAL & PHARMACEUTICAL BULLETIN　Vol. 33　No. 5　p. 780-783　2010/05　Research paper (scientific journal)

Mutant TNF-alpha, mTNF-K90R, is a novel candidate adjuvant for a mucosal vaccine against HIV

H. Kayamuro, Y. Abe, Y. Yoshioka, K. Katayama, T. Yoshida, K. Yamashita, T. Yoshikawa, Y. Kawai, T. Mayumi, T. Hiroi, N. Itoh, K. Nagano, H. Kamada, S. Tsunoda, Y. Tsutsumi

PHARMAZIE　Vol. 65　No. 4　p. 254-256　2010/04　Research paper (scientific journal)

Generation of mouse macrophages expressing membrane-bound TNF variants with selectivity for TNFR1 or TNFR2

Hiroko Shibata, Yasuhiro Abe, Yasuo Yoshioka, Tetsuya Nomura, Masaki Sato, Hiroyuki Kayamuro, Tomoyuki Kawara, Shuhei Arita, Tsuyoshi Furuya, Kazuya Nagano, Tomoaki Yoshikawa, Haruhiko Kamada, Shin-ichi Tsunoda, Yasuo Tsutsumi

CYTOKINE　Vol. 50　No. 1　p. 75-83　2010/04　Research paper (scientific journal)

Creation of a LIGHT mutant with the capacity to evade the decoy receptor for cancer therapy

Tomohiro Morishige, Yasuo Yoshioka, Hiroshi Inakura, Aya Tanabe, Xinglei Yao, Shin-ichi Tsunoda, Yasuo Tsutsumi, Yohei Mukai, Naoki Okada, Shinsaku Nakagawa

BIOMATERIALS　Vol. 31　No. 12　p. 3357-3363　2010/04　Research paper (scientific journal)

「貼るワクチン」の開発 生分解性マイクロニードルを用いたマラリアワクチンの開発

綾部 有里香, 松尾 一彦, 権 英淑, 神山 文男, 堀井 俊宏, 向 洋平, 吉岡 靖雄, 岡田 直貴, 中川 晋作

日本薬学会年会要旨集　Vol. 130年会　No. 4　p. 163-163　2010/03

Size-dependent cytotoxic effects of amorphous silica nanoparticles on Langerhans cells

H. Nabeshi, T. Yoshikawa, K. Matsuyama, Y. Nakazato, A. Arimori, M. Isobe, S. Tochigi, S. Kondoh, T. Hirai, T. Akase, T. Yamashita, K. Yamashita, T. Yoshida, K. Nagano, Y. Abe, Y. Yoshioka, H. Kamada, T. Imazawa, N. Itoh, S. Tsunoda, Y. Tsutsumi

PHARMAZIE　Vol. 65　No. 3　p. 199-201　2010/03　Research paper (scientific journal)

Tumor-targeting CTL expressing a single-chain FV specific for VEGFR2

Naoko Kanagawa, Tatsuya Yanagawa, Yohei Mukai, Yasuo Yoshioka, Naoki Okada, Shinsaku Nakagawa

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 394　No. 1　p. 54-58　2010/03　Research paper (scientific journal)

Creation of a lysine-deficient LIGHT mutant with the capacity for site-specific PEGylation and low affinity for a decoy receptor

Tomohiro Morishige, Yasuo Yoshioka, Hiroshi Inakura, Aya Tanabe, Xinglei Yao, Shin-ichi Tsunoda, Yasuo Tsutsumi, Yohei Mukai, Naoki Okada, Shinsaku Nakagawa

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 393　No. 4　p. 888-893　2010/03　Research paper (scientific journal)

Creation of lysine-deficient mutant lymphotoxin-alpha with receptor selectivity by using a phage display system

Yasuo Yoshioka, Hikaru Watanabe, Tomohiro Morishige, Xinglei Yao, Shinji Ikemizu, Chioko Nagao, Shandar Ahmad, Kenji Mizuguchi, Shin-ichi Tsunoda, Yasuo Tsutsumi, Yohei Mukai, Naoki Okada, Shinsaku Nakagawa

BIOMATERIALS　Vol. 31　No. 7　p. 1935-1943　2010/03　Research paper (scientific journal)

Creation of an improved mutant TNF with TNFR1-selectivity and antagonistic activity by phage display technology

T. Nomura, Y. Abe, H. Kamada, M. Inoue, T. Kawara, S. Arita, T. Furuya, K. Minowa, Y. Yoshioka, H. Shibata, H. Kayamuro, T. Yamashita, K. Nagano, T. Yoshikawa, Y. Mukai, S. Nakagawa, S. Tsunoda, Y. Tsutsumi

PHARMAZIE　Vol. 65　No. 2　p. 93-96　2010/02　Research paper (scientific journal)

Titanium dioxide induces different levels of IL-1 beta production dependent on its particle characteristics through caspase-1 activation mediated by reactive oxygen species and cathepsin B

Tomohiro Morishige, Yasuo Yoshioka, Aya Tanabe, Xinglei Yao, Shin-ichi Tsunoda, Yasuo Tsutsumi, Yohei Mukai, Naoki Okada, Shinsaku Nakagawa

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 392　No. 2　p. 160-165　2010/02　Research paper (scientific journal)

Evaluation of Synthetic Cell-Penetrating Peptides, Pro-Rich Peptide and Octaargine Derivatives, as Adenovirus Vector Carrier

Shinya Kida, Yusuke Eto, Yasuo Yoshioka, Shinsaku Nakagawa, Koichi Kawasaki, Mitsuko Maeda

PROTEIN AND PEPTIDE LETTERS　Vol. 17　No. 2　p. 164-167　2010　Research paper (scientific journal)

Structure of the TNF-TNFR2 complex

Mukai Y, Nakamura T, Yoshikawa M, Yoshioka Y, Tsunoda S, Nakagawa S, Yamagata Y, Tsutsumi Y

Sci Signal.　Vol. 2010 Nov 16;3(148)　No. 148　2010　Research paper (scientific journal)

Comparison of the anti-tumor activity of native, secreted, and membrane-bound LIGHT in mouse tumor models

Tomohiro Morishige, Yasuo Yoshioka, Aya Tanabe, Xinglei Yao, Hiroyuki Mizuguchi, Shin-ichi Tsunoda, Yasuo Tsutsumi, Yohei Mukai, Naoki Okada, Shinsaku Nakagawa

INTERNATIONAL IMMUNOPHARMACOLOGY　Vol. 10　No. 1　p. 26-33　2010/01　Research paper (scientific journal)

The treatment of established murine collagen-induced arthritis with a TNFR1-selective antagonistic mutant TNF

Hiroko Shibata, Yasuo Yoshioka, Yasuhiro Abe, Akiko Ohkawa, Tetsuya Nomura, Kyoko Minowa, Yohei Mukai, Shinsaku Nakagawa, Madoka Taniai, Tsunetaka Ohta, Haruhiko Kamada, Shin-ichi Tsunoda, Yasuo Tsutsumi

BIOMATERIALS　Vol. 30　No. 34　p. 6638-6647　2009/12　Research paper (scientific journal)

Systemic administration of a PEGylated adenovirus vector with a cancer-specific promoter is effective in a mouse model of metastasis

X. Yao, Y. Yoshioka, T. Morishige, Y. Eto, H. Watanabe, Y. Okada, H. Mizuguchi, Y. Mukai, N. Okada, S. Nakagawa

GENE THERAPY　Vol. 16　No. 12　p. 1395-1404　2009/12　Research paper (scientific journal)

LIGHT protein suppresses tumor growth by augmentation of immune response

Tomohiro Morishige, Yasuo Yoshioka, Hiroshi Inakura, Aya Tanabe, Hikaru Watanabe, Xinglei Yao, Shin-ichi Tsunoda, Yasuo Tsutsumi, Yohei Mukai, Naoki Okada, Shinsaku Nakagawa

IMMUNOLOGY LETTERS　Vol. 127　No. 1　p. 33-38　2009/12　Research paper (scientific journal)

Creation of lysine-deficient mutant lymphotoxin-alpha with receptor selectivity by using phage display

Yoshioka Yasuo, Watanabe Hikaru, Morishige Tomohiro, Yao Xinglei, Ikemizu Shinji, Nagao Chioko, Ahmad Shandar, Mizuguchi Kenji, Tsutsumi Yasuo, Mukai Yohei, Okada Naoki, Nakagawa Shinsaku

CYTOKINE　Vol. 48　No. 1月2日　2009/10

TNFR1-selectivity improvement of mutant TNF with antagonistic activity

Tetsuya Nomura, Yasuhiro Abe, Masaki Inoue, Yasuo Yoshioka, Hiroyuki Kayamuro, Yohei Mukai, Madoka Taniai, Tsunetaka Ohta, Shinsaku Nakagawa, Haruhiko Kamada, Shin-ichi Tsunoda, Yasuo Tsutsumi

CYTOKINE　Vol. 48　No. 1-2　p. 73-73　2009/10

Characterization of mucosal and systemic immune responses elicited by interleukin cytokines as mucosal adjuvant against influenza virus

Hiroyuki Kayamuro, Yasuo Yoshioka, Yasuhiro Abe, Shu-hei Arita, Kazufumi Katayama, Haruhiko Kamada, Tetsuya Nomura, Norio Itoh, Tomoaki Yoshikawa, Kazuya Nagano, Shin-ich Tsunoda, Yasuo Tsutsumi

CYTOKINE　Vol. 48　No. 1-2　p. 109-109　2009/10

Mast cells are required for interleukin-18 dependent mucosal immune responses

Yasuhiro Abe, Hiroyuki Kayamuro, Yasuo Yoshioka, Shu-hei Arita, Haruhiko Kamada, Tetsuya Nomura, Norio Itoh, Tomoaki Yoshikawa, Kazuya Nagano, Shin-ich Tsunoda, Yasuo Tsutsumi

CYTOKINE　Vol. 48　No. 1-2　p. 111-111　2009/10

The use of a mutant TNF-alpha as a vaccine adjuvant for the induction of mucosal immune responses

Hiroyuki Kayamuro, Yasuhiro Abe, Yasuo Yoshioka, Kazufumi Katayama, Tetsuya Nomura, Tokuyuki Yoshida, Kohei Yamashita, Tomoaki Yoshikawa, Yuichi Kawai, Tadanori Mayumi, Takachika Hiroi, Norio Itoh, Kazuya Nagano, Haruhiko Kamada, Shin-ichi Tsunoda, Yasuo Tsutsumi

BIOMATERIALS　Vol. 30　No. 29　p. 5869-5876　2009/10　Research paper (scientific journal)

Novel protein engineering strategy for creating highly receptor-selective mutant TNFs

Tetsuya Nomura, Yasuhiro Abe, Haruhiko Kamada, Masaki Inoue, Tomoyuki Kawara, Shuhei Arita, Takeshi Furuya, Yasuo Yoshioka, Hiroko Shibata, Hiroyuki Kayamuro, Takuya Yamashita, Kazuya Nagano, Tomoaki Yoshikawa, Yohei Mukai, Shinsaku Nakagawa, Madoka Taniai, Tsunetaka Ohta, Shin-ichi Tsunoda, Yasuo Tsutsumi

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 388　No. 4　p. 667-671　2009/10　Research paper (scientific journal)

Nanosilicas with different sizes and surface charges induce different profiles of cytokine production on macrophages

Yasuo Yoshioka, Tomohiro Morishige, Aya Tanabe, Yasuo Tsutsumi, Yohei Mukai, Naoki Okada, Shinsaku Nakagawa

TOXICOLOGY LETTERS　Vol. 189　p. S182-S182　2009/09

Fast Binding Kinetics and Conserved 3D Structure Underlie the Antagonistic Activity of Mutant TNF: Useful Information for Designing Artificial Proteo-Antagonists

Yohei Mukai, Teruya Nakamura, Yasuo Yoshioka, Hiroko Shibata, Yasuhiro Abe, Tetsuya Nomura, Madoka Taniai, Tsunetaka Ohta, Shinsaku Nakagawa, Shin-ichi Tsunoda, Haruhiko Kamada, Yuriko Yamagata, Yasuo Tsutsumi

JOURNAL OF BIOCHEMISTRY　Vol. 146　No. 2　p. 167-172　2009/08　Research paper (scientific journal)

Transduction of adenovirus vectors modified with cell-penetrating peptides

Yusuke Eto, Yasuo Yoshioka, Ratima Asavatanabodee, Shinya Kida, Mitsuko Maeda, Yohei Mukai, Hiroyuki Mizuguchi, Koichi Kawasaki, Naoki Okada, Shinsaku Nakagawa

PEPTIDES　Vol. 30　No. 8　p. 1548-1552　2009/08　Research paper (scientific journal)

Arsenic Trioxide Inhibits Human T Cell-Lymphotropic Virus-1-Induced Syncytiums by Down-Regulating gp46

Hiromi Nabeshi, Tomoaki Yoshikawa, Haruhiko Kamada, Hiroko Shibata, Toshiki Sugita, Yasuhiro Abe, Kazuya Nagano, Tetsuya Nomura, Kyoko Minowa, Takuya Yamashita, Norio Itoh, Yasuo Yoshioka, Shin-ichi Tsunoda, Yasuo Tsutsumi

BIOLOGICAL & PHARMACEUTICAL BULLETIN　Vol. 32　No. 7　p. 1286-1288　2009/07　Research paper (scientific journal)

TNF superfamily member, TL1A, is a potential mucosal vaccine adjuvant

Hiroyuki Kayamuro, Yasuo Yoshioka, Yasuhiro Abe, Kazufumi Katayama, Tokuyuki Yoshida, Kohei Yamashita, Tomoaki Yoshikawa, Takachika Hiroi, Norio Itoh, Yuichi Kawai, Tadanori Mayumi, Haruhiko Kamada, Shin-ichi Tsunoda, Yasuo Tsutsumi

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 384　No. 3　p. 296-300　2009/07　Research paper (scientific journal)

Molecular cloning, expression, and characterization of a major 38-kd cochineal allergen

Yoko Ohgiya, Fumihiro Arakawa, Hiroshi Akiyama, Yasuo Yoshioka, Yoshiki Hayashi, Shinobu Sakai, Sumio Ito, Yuko Yamakawa, Satoru Ohgiya, Zenro Ikezawa, Reiko Teshima

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY　Vol. 123　No. 5　p. 1157-1162　2009/05　Research paper (scientific journal)

Direct cell entry of gold/iron-oxide magnetic nanoparticles in adenovirus mediated gene delivery

Kazumasa Kamei, Yohei Mukai, Hiroki Kojima, Tomoaki Yoshikawa, Mai Yoshikawa, George Kiyohara, Takao A. Yamamoto, Yasuo Yoshioka, Naoki Okada, Satoshi Seino, Shinsaku Nakagawa

BIOMATERIALS　Vol. 30　No. 9　p. 1809-1814　2009/03　Research paper (scientific journal)

Crystallization and preliminary X-ray analysis of the tumour necrosis factor alpha-tumour necrosis factor receptor type 2 complex

Yohei Mukai, Teruya Nakamura, Yasuo Yoshioka, Shin-ichi Tsunoda, Haruhiko Kamada, Shinsaku Nakagawa, Yuriko Yamagata, Yasuo Tsutsumi

ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS　Vol. 65　p. 295-298　2009/03　Research paper (scientific journal)

CREATION OF MUTANT LYMPHOTOXIN-ALPHAS WITH ENHANCED BIOACTIVITIES BY PHAGE DISPLAY TECHNIQUE

Yasuo Yoshioka, Hikaru Watanabe, Yasuo Tsutsumi, Yohei Mukai, Naoki Okada, Shinsaku Nakagawa

JOURNAL OF PHYSIOLOGICAL SCIENCES　Vol. 59　p. 157-157　2009

Structure-function relationship of tumor necrosis factor (TNF) and its receptor interaction based on 3D structural analysis of a fully active TNFR1-selective TNF mutant

Mukai Y, Shibata H, Nakamura T, Yoshioka Y, Abe Y, Nomura T, Taniai M, Ohta T, Ikemizu S, Nakagawa S, Tsunoda S, Kamada H, Yamagata Y, Tsutsumi Y

J Mol Biol　2009/01　Research paper (scientific journal)

Orally administered apple procyanidins protect against experimental inflammatory bowel disease in mice

Yasuo Yoshioka, Hiroshi Akiyama, Masataka Nakano, Toshihiko Shoji, Tomomasa Kanda, Yasuyuki Ohtake, Toshichika Takita, Rieko Matsuda, Tamio Maitani

INTERNATIONAL IMMUNOPHARMACOLOGY　Vol. 8　No. 13-14　p. 1802-1807　2008/12　Research paper (scientific journal)

Tat conjugation of adenovirus vector broadens tropism and enhances transduction efficiency

Yasuo Yoshioka, Ratima Asavatanabodee, Yusuke Eto, Hikaru Watanabe, Tomohiro Morishige, Xinglei Yao, Shinya Kida, Mitsuko Maeda, Yohei Mukai, Hiroyuki Mizuguchi, Koichi Kawasaki, Naoki Okada, Shinsaku Nakagawa

LIFE SCIENCES　Vol. 83　No. 21-22　p. 747-755　2008/11　Research paper (scientific journal)

The therapeutic effect of TNFR1-selective antagonistic mutant TNF-alpha in murine hepatitis models

Hiroko Shibata, Yasuo Yoshioka, Akiko Ohkawa, Yasuhiro Abe, Tetsuya Nomura, Yohei Mukai, Shinsaku Nakagawa, Madoka Taniai, Tsunetaka Ohta, Tadanori Mayumi, Haruhiko Kamada, Shin-ichi Tsunoda, Yasuo Tsutsumi

CYTOKINE　Vol. 44　No. 2　p. 229-233　2008/11　Research paper (scientific journal)

Fine tuning of receptor-selectivity for TNF using a phage display system with one-step competitive-subtractive panning

Yasuhiro Abe, Hiroko Shibata, Tetsuya Nomura, Hiroyuki Kayamuro, Yohei Mukai, Tomoaki Yoshikawa, Yasuo Yoshioka, Madoka Taniai, Tsunetaka Ohta, Shinsaku Nakagawa, Haruhiko Kamada, Shin-ichi Tsunoda, Yasuo Tsutsumi

CYTOKINE　Vol. 43　No. 3　p. 294-295　2008/09

Creation of mutant TNF with TNF receptor-1 selective antagonistic activity for the development of a novel autoimune disease drug

Tetsuya Nomura, Yasuhiro Abe, Yasuo Yoshioka, Hiroko Shibata, Hiroyuki Kayamuro, Yohei Mukai, Madoka Taniai, Tsunetaka Ohta, Shinsaku Nakagawa, Haruhiko Kamada, Shin-ichi Tsunoda, Yasuo Tsutsumi

CYTOKINE　Vol. 43　No. 3　p. 259-259　2008/09

Structure-function relationship of TNF based on 3D structural analysis of fully active TNFR1-selective TNF mutant

Yohei Mukai, Hiroko Shibata, Teruya Nakamura, Yasuo Yoshioka, Yasuhiro Abe, Tetsuya Nomura, Madoka Taniai, Tsunetaka Ohta, Shinji Ikemizu, Shinsaku Nakagawa, Shin-ichi Tsunoda, Haruhiko Kamada, Yuriko Yamagata, Yasuo Tsutsumi

CYTOKINE　Vol. 43　No. 3　p. 295-295　2008/09

Ligand-independent assembly of purified soluble magic roundabout (Robo4), a tumor-specific endothelial marker

Mai Yoshikawa, Yohei Mukai, Yoshiaki Okada, Yasuo Yoshioka, Shin-ichi Tsunoda, Yasuo Tsutsumi, Naoki Okada, William C. Aird, Takefumi Doi, Shinsaku Nakagawa

PROTEIN EXPRESSION AND PURIFICATION　Vol. 61　No. 1　p. 78-82　2008/09　Research paper (scientific journal)

Antitumor mechanism of intratumoral injection with IL-12-expressing adenoviral vector against IL-12-unresponsive tumor

Naoko Kanagawa, Jian-Qing Gao, Yoshiaki Motomura, Tatsuya Yanagawa, Yohei Mukai, Yasuo Yoshioka, Naoki Okada, Shinsaku Nakagawa

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 372　No. 4　p. 821-825　2008/08　Research paper (scientific journal)

Organelle-targeted delivery of biological macromolecules using the protein transduction domain: Potential applications for peptide aptamer delivery into the nucleus

Tomoaki Yoshikawa, Toshiki Sugita, Yohei Mukai, Natsue Yamanada, Kazuya Nagano, Hiromi Nabeshi, Yasuo Yoshioka, Shinsaku Nakagawa, Yasuhiro Abe, Haruhiko Kamada, Shin-ichi Tsunoda, Yasuo Tsutsumi

JOURNAL OF MOLECULAR BIOLOGY　Vol. 380　No. 5　p. 777-782　2008/07　Research paper (scientific journal)

Simple and highly sensitive assay system for TNFR2-mediated soluble- and transmembrane-TNF activity

Yasuhiro Abe, Tomoaki Yoshikawa, Haruhiko Kamada, Hiroko Shibata, Tetsuya Nomura, Kyoko Minowa, Hiroyuki Kayamuro, Kazufumi Katayama, Hiroyuki Miyoshi, Yohei Mukai, Yasuo Yoshioka, Shinsaku Nakagawa, Shin-ichi Tsunoda, Yasuo Tsutsumi

JOURNAL OF IMMUNOLOGICAL METHODS　Vol. 335　No. 1-2　p. 71-78　2008/06　Research paper (scientific journal)

Comparative study on transduction and toxicity of protein transduction domains

T. Sugita, T. Yoshikawa, Y. Mukai, N. Yamanada, S. Imai, K. Nagano, Y. Yoshida, H. Shibata, Y. Yoshioka, S. Nakagawa, H. Kamada, S-i Tsunoda, Y. Tsutsumi

BRITISH JOURNAL OF PHARMACOLOGY　Vol. 153　No. 6　p. 1143-1152　2008/03　Research paper (scientific journal)

Preparation of a Tat-related transporter peptide for carrying the adenovirus vector into cells

Shinya Kida, Yusuke Eto, Mitsuko Maeda, Yasuo Yoshioka, Shinsaku Nakagawa, Keiko Hojo, Yuko Tsuda, Tadanori Mayumi, Koichi Kawasaki

PROTEIN AND PEPTIDE LETTERS　Vol. 15　No. 2　p. 219-222　2008/02　Research paper (scientific journal)

Development of amphiphilic gamma-PGA-nanoparticle based tumor vaccine: Potential of the nanoparticulate cytosolic protein delivery carrier

Tomoaki Yoshikawa, Naoki Okada, Atsushi Oda, Kazuhiko Matsuo, Keisuke Matsuo, Yohei Mukai, Yasuo Yoshioka, Takami Akagi, Mitsuru Akashi, Shinsaku Nakagawa

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 366　No. 2　p. 408-413　2008/02　Research paper (scientific journal)

3P-081 Creation of TNFR1-selective mutant lymphotoxin alpha using phage display system(The 46th Annual Meeting of the Biophysical Society of Japan)

Watanabe Hikaru, Yoshioka Yasuo, Morishige Tomohiro, Tsunoda Shin-ichi, Tsutsumi Yasuo, Mukai Yohei, Okada Naoki, Nakagawa Shinsaku

Seibutsu Butsuri　Vol. 48　p. S139-S140　2008

Creation and x-ray structure analysis of the tumor necrosis factor receptor-1-selective mutant of a tumor necrosis factor-alpha antagonist

Hiroko Shibata, Yasuo Yoshioka, Akiko Ohkawa, Kyoko Minowa, Yohei Mukai, Yasuhiro Abe, Madoka Taniai, Tetsuya Nomura, Hiroyuki Kayamuro, Hiromi Nabeshi, Toshiki Sugita, Sunao Imai, Kazuya Nagano, Tomoaki Yoshikawa, Takuya Fujita, Shinsaku Nakagawa, Akira Yamamoto, Tsunetaka Ohta, Takao Hayakawa, Tadanori Mayumi, Peter Vandenabeele, Bharat B. Aggarwal, Teruya Nakamura, Yuriko Yamagata, Shin-ichi Tsunoda, Haruhiko Kamada, Yasuo Tsutsumi

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 283　No. 2　p. 998-1007　2008/01　Research paper (scientific journal)

Efficient generation of antigen-specific cellular immunity by vaccination with poly(γ-glutamic acid) nanoparticles entrapping endoplasmic reticulum-targeted peptides

Keisuke Matsuo, Tomoaki Yoshikawa, Atsushi Oda, Takami Akagi, Mitsuru Akashi, Yohei Mukai, Yasuo Yoshioka, Naoki Okada, Shinsaku Nakagawa

Biochemical and Biophysical Research Communications　Vol. 362　No. 4　p. 1069-1072　2007/11/03　Research paper (scientific journal)

Improved cytosolic translocation and tumor-killing activity of Tat-shepherdin conjugates mediated by co-treatment with Tat-fused endosome-disruptive HA2 peptide

Toshiki Sugita, Tomoaki Yoshikawa, Yohei Muka, Natsue Yamanada, Imai Sunao, Kazuya Nagano, Yasunobu Yoshida, Hiroko Shibata, Yasuo Yoshioka, Shinsaku Nakagawa, Haruhiko Kamada, Shin-Ichi Tsunoda, Yasuo Tsutsumi

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 363　No. 4　p. 1027-1032　2007/11　Research paper (scientific journal)

TERT promoter-driven adenovirus vector for cancer gene therapy via systemic injection

Xinglei Yao, Yasuo Yoshioka, Yusuke Eto, Tomohiro Morishige, Yuka Okada, Hiroyuki Mizuguchi, Yohei Mukal, Naoki Okada, Shinsaku Nakagawa

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 362　No. 2　p. 419-424　2007/10　Research paper (scientific journal)

Effective tumor targeted gene transfer using PEGylated adenovirus vector via systemic administration.

Jian-Qing Gao, Yusuke Eto, Yasuo Yoshioka, Fumiko Sekiguchi, Shinnosuke Kurachi, Tomohiro Morishige, Xinglei Yao, Hikaru Watanabe, Ratima Asavatanabodee, Fuminori Sakurai, Hiroyuki Mizuguchi, Yuka Okada, Yohei Mukai, Yasuo Tsutsumi, Tadanori Mayumi, Naoki Okada, Shinsaku Nakagawa

Journal of controlled release : official journal of the Controlled Release Society　Vol. 122　No. 1　p. 102-10　2007/09/11　Research paper (scientific journal)

Role of amino acid residue 90 in bioactivity and receptor binding capacity of tumor necrosis factor mutants.

Hiroko Shibata, Haruhiko Kamada, Kyoko Kobayashi-Nishibata, Yasuo Yoshioka, Toshihide Nishibata, Yasuhiro Abe, Tetsuya Nomura, Hiromi Nabeshi, Kyoko Minowa, Yohei Mukai, Shinsaku Nakagawa, Tadanori Mayumi, Shin-Ichi Tsunoda, Yasuo Tsutsumi

Biochimica et biophysica acta　Vol. 1774　No. 8　p. 1029-35　2007/08　Research paper (scientific journal)

Role of amino acid residue 90 in bioactivity and receptor binding capacity of tumor necrosis factor mutants

Hiroko Shibata, Haruhiko Kamada, Kyoko Kobayashi-Nishibata, Yasuo Yoshioka, Toshihide Nishibata, Yasuhiro Abe, Tetsuya Nomura, Hiromi Nabeshi, Kyoko Minowa, Yohei Mukai, Shinsaku Nakagawa, Tadanori Mayumi, Shin-ichi Tsunoda, Yasuo Tsutsumi

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS　Vol. 1774　No. 8　p. 1029-1035　2007/08　Research paper (scientific journal)

Development of the valuable cell line which evaluate the bioactivity through TNFR2 using chimeric receptor strategy

Yasuhiro Abe, Yasuo Yoshioka, Tetsuya Nomura, Hiromi Nabeshi, Hiroyuki Kayamuro, Kyoko Minowa, Hiroko Shibata, Shinsaku Nakagawa, Haruhiko Kamada, Shin-Ichi Tsunoda, Yasuo Tsutsumi

CYTOKINE　Vol. 39　No. 1　p. 1-1　2007/07

Site-specific PEGylation of a lysine-deficient TNF superfamily with full bioactivity

Yasuo Yoshioka, Tomohiro Morishige, Hikaru Watanabe, Aya Tanabe, Yasuhiro Abe, Yohei Mukai, Harubiko Kamada, Naoki Okada, Shinsaku Nakagawa, Yasuo Tsutsumi

CYTOKINE　Vol. 39　No. 1　p. 47-47　2007/07

Role of amino acid residue 90 in bioactivity and receptor binding capacity of tumor necrosis factor mutants

Kamada Haruhiko, Tsutsumi Yasuo, Yoshioka Yasuo, Shibata Hiroko, Abe Yasuhiro, Nomura Tetsuya, Minowa Kyoko, Nabeshi Hiromi, Nakagawa Shinsaku, Tsunoda Shin-ichi

Abstracts for Annual Meeting of Japanese Proteomics Society　Vol. 2007　No. 0　p. 154-154　2007

A strategy for efficient cross-presentation of CTL-epitope peptides leading to enhanced induction of in vivo tumor immunity

Akira Hayashi, Hisashi Wakita, Tomoaki Yoshikawa, Tsuyoshi Nakanishi, Yasuo Tsutsumi, Tadanori Mayumi, Yohei Mukai, Yasuo Yoshioka, Naoki Okada, Shinsaku Nakagawa

JOURNAL OF CONTROLLED RELEASE　Vol. 117　No. 1　p. 11-19　2007/01　Research paper (scientific journal)

Interlaboratory evaluation of two enzyme-linked immunosorbent assay kits for the detection of egg, milk, wheat, buckwheat, and peanut in foods

Rieko Matsuda, Yasuo Yoshioka, Hiroshi Akiyama, Kenichi Aburatani, Yumiko Watanabe, Takashi Matsumoto, Naoki Morishita, Hidetaka Sato, Takashi Mishima, Reiko Gamo, Yasunori Kihira, Tamio Maitani

JOURNAL OF AOAC INTERNATIONAL　Vol. 89　No. 6　p. 1600-1608　2006/11　Research paper (scientific journal)

Chondroitin sulfate intake inhibits the IgE-mediated allergic response by down-regulating Th2 responses in mice

Shinobu Sakai, Hiroshi Akiyama, Yuji Sato, Yasuo Yoshioka, Robert J. Linhardt, Yukihiro Goda, Tamio Maitani, Toshihiko Toida

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 281　No. 29　p. 19872-19880　2006/07　Research paper (scientific journal)

1 食物アレルゲン(ピーナッツ,魚卵)(シンポジウム10 今注目すべきアレルゲンと病態,第18回日本アレルギー学会春季臨床大会)

穐山 浩, 吉岡 靖雄, 松田 りえ子, 佐伯 宏樹, 渡辺 一彦, 宇理須 厚雄, 米谷 民雄

アレルギー　Vol. 55　No. 3　p. 352-352　2006

Profile analysis and immunoglobulin E reactivity of wheat protein hydrolysates

H Akiyama, K Sakata, Y Yoshioka, Y Murata, Y Ishihara, R Teshima, J Sawada, T Maitani

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY　Vol. 140　No. 1　p. 36-42　2006　Research paper (scientific journal)

プロシアニジンによる大腸炎発症予防効果とその作用メカニズムに関する検討

吉岡 靖雄, 穐山 浩, 庄司 俊彦, 滝田 聖親, 神田 智正, 松田 りえ子, 米谷 民雄

アレルギー　Vol. 54　No. 8-9　p. 1102-1102　2005/09

Dietary unripe apple polyphenol inhibits the development of food allergies in murine models

H Akiyama, Y Sato, T Watanabe, MH Nagaoka, Y Yoshioka, T Shoji, T Kanda, K Yamada, M Totsuka, R Teshima, J Sawada, Y Goda, T Maitani

FEBS LETTERS　Vol. 579　No. 20　p. 4485-4491　2005/08　Research paper (scientific journal)

Functionalization of tumor necrosis factor-alpha using phage display technique and PEGylation improves its antitumor therapeutic window

H Shibata, Y Yoshioka, S Ikemizu, K Kobayashi, Y Yamamoto, Y Mukai, T Okamoto, M Taniai, M Kawamura, Y Abe, S Nakagawa, T Hayakawa, S Nagata, Y Yamagata, T Mayumi, H Kamada, Y Tsutsumi

CLINICAL CANCER RESEARCH　Vol. 10　No. 24　p. 8293-8300　2004/12　Research paper (scientific journal)

Optimal construction of non-immune scFv phage display libraries from mouse bone marrow and spleen established to select specific scFvs efficiently binding to antigen

T Okamoto, Y Mukai, Y Yoshioka, H Shibata, M Kawamura, Y Yamamoto, S Nakagawa, H Kamada, T Hayakawa, T Mayumi, Y Tsutsumi

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 323　No. 2　p. 583-591　2004/10　Research paper (scientific journal)

Effective accumulation of poly(vinylpyrrolidone-co-vinyl laurate) into the spleen.

Yasuo Yoshioka, Yasuo Tsutsumi, Yohei Mukai, Hiroko Shibata, Takayuki Okamoto, Yoshihisa Kaneda, Shin-ichi Tsunoda, Haruhiko Kamada, Keiichi Koizumi, Yoko Yamamoto, Yu Mu, Hiroshi Kodaira, Keiko Sato-Kamada, Shinsaku Nakagawa, Tadanori Mayumi

Journal of biomedical materials research. Part A　Vol. 70　No. 2　p. 219-23　2004/08/01　Research paper (scientific journal)

The targeting of anionized polyvinylpyrrolidone to the renal system

H Kodaira, Y Tsutsumi, Y Yoshioka, H Kamada, Y Kaneda, Y Yamamoto, S Tsunoda, T Okamoto, Y Mukai, H Shibata, S Nakagawa, T Mayumi

BIOMATERIALS　Vol. 25　No. 18　p. 4309-4315　2004/08　Research paper (scientific journal)

Effective accumulation of poly(vinylpyrrolidone-co-vinyl laurate) into the spleen

Y Yoshioka, Y Tsutsumi, Y Mukai, H Shibata, T Okamoto, Y Kaneda, S Tsunoda, H Kamada, K Koizumi, Y Yamamoto, Y Mu, H Kodaira, K Sato-Kamada, S Nakagawa, T Mayumi

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A　Vol. 70A　No. 2　p. 219-223　2004/08　Research paper (scientific journal)

The use of PVP as a polymeric carrier to improve the plasma half-life of drugs

Y Kaneda, Y Tsutsumi, Y Yoshioka, H Kamada, Y Yamamoto, H Kodaira, S Tsunoda, T Okamoto, Y Mukai, H Shibata, S Nakagawa, T Mayumi

BIOMATERIALS　Vol. 25　No. 16　p. 3259-3266　2004/07　Research paper (scientific journal)

Design of a pH-sensitive polymeric carrier for drug release and its application in cancer therapy

H Kamada, Y Tsutsumi, Y Yoshioka, Y Yamamoto, H Kodaira, S Tsunoda, T Okamoto, Y Mukai, H Shibata, S Nakagawa, T Mayumi

CLINICAL CANCER RESEARCH　Vol. 10　No. 7　p. 2545-2550　2004/04　Research paper (scientific journal)

Poly(vinylpyrrolidone-co-dimethyl maleic acid) as a novel renal targeting carrier

Y Yamamoto, Y Tsutsumi, Y Yoshioka, H Kamada, K Sato-Kamada, T Okamoto, Y Mukai, H Shibata, S Nakagawa, T Mayumi

JOURNAL OF CONTROLLED RELEASE　Vol. 95　No. 2　p. 229-237　2004/03　Research paper (scientific journal)

Optimal site-specific PEGylation of mutant TNF-alpha improves its antitumor potency

Y Yoshioka, Y Tsutsumi, S Ikemizu, Y Yamamoto, H Shibata, T Nishibata, Y Mukai, T Okamoto, M Taniai, M Kawamura, Y Abe, S Nakagawa, S Nagata, Y Yamagata, T Mayumi

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 315　No. 4　p. 808-814　2004/03　Research paper (scientific journal)

Selective enhancer of tumor vascular permeability for optimization of cancer chemotherapy

Y Yoshioka, Y Tsutsumi, H Kamada, T Kihira, S Tsunoda, Y Yamamoto, T Okamoto, H Shibata, Y Mukai, M Taniai, T Shimizu, M Kawamura, Y Abe, S Nakagawa, T Mayumi

BIOLOGICAL & PHARMACEUTICAL BULLETIN　Vol. 27　No. 3　p. 437-439　2004/03　Research paper (scientific journal)

Combination effects of complement regulatory proteins and anti-complement polymer.

Yasuo Yoshioka, Ryo Suzuki, Takayuki Okamoto, Naoki Okada, Yohei Mukai, Hiroko Shibata, Yasuo Tsutsumi, Natsuki Dohi, Noriko Okada, Shinsaku Nakagawa, Tadanori Mayumi

Biochimica et biophysica acta　Vol. 1624　No. 1-3　p. 54-9　2003/12/05　Research paper (scientific journal)

Combination effects of complement regulatory proteins and anti-complement polymer

Yasuo Yoshioka, Ryo Suzuki, Takayuki Okamoto, Naoki Okada, Yohei Mukai, Hiroko Shibata, Yasuo Tsutsumi, Natsuki Dohi, Noriko Okada, Shinsaku Nakagawa, Tadanori Mayumi

Biochimica et Biophysica Acta - General Subjects　Vol. 1624　No. 1-3　p. 54-59　2003/12/05　Research paper (scientific journal)

Anti-angiogenic effects of dimethyl sulfoxide on endothelial cells

K Koizumi, Y Tsutsumi, Y Yoshioka, M Watanabe, T Okamoto, Y Mukai, S Nakagawa, T Mayumi

BIOLOGICAL & PHARMACEUTICAL BULLETIN　Vol. 26　No. 9　p. 1295-1298　2003/09　Research paper (scientific journal)

Incorporation of adult organ-derived endothelial cells into tumor blood vessel.

Koizumi K, Tsutsumi Y, Kamada H, Yoshioka Y, Watanabe M, Yamamoto Y, Okamoto T, Mukai Y, Nakagawa S, Tani Y, Mayumi T

Biochem Biophys Res Commun.　2003/07　Research paper (scientific journal)

Site-specific PEGylation of a lysine-deficient TNF-alpha with full bioactivity

Y Yamamoto, Y Tsutsumi, Y Yoshioka, T Nishibata, K Kobayashi, T Okamoto, Y Mukai, T Shimizu, S Nakagawa, S Nagata, T Mayumi

NATURE BIOTECHNOLOGY　Vol. 21　No. 5　p. 546-552　2003/05　Research paper (scientific journal)

A novel cytomedical vehicle capable of protecting cells against complement

Y Yoshioka, R Suzuki, H Oka, N Okada, T Okamoto, T Yoshioka, Y Mukai, H Shibata, Y Tsutsumi, S Nakagawa, J Miyazaki, T Mayumi

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 305　No. 2　p. 353-358　2003/05　Research paper (scientific journal)

Synthesis of a poly(vinylpyrrolidone-co-dimethyl maleic anhydride) co-polymer and its application for renal drug targeting

H Kamada, Y Tsutsumi, K Sato-Kamada, Y Yamamoto, Y Yoshioka, T Okamoto, S Nakagawa, S Nagata, T Mayumi

NATURE BIOTECHNOLOGY　Vol. 21　No. 4　p. 399-404　2003/04　Research paper (scientific journal)

Development of a novel cytomedical treatment that can protect entrapped cells from host humoral immunity

R Suzuki, Y Yoshioka, E Kitano, T Yoshioka, H Oka, T Okamoto, N Okada, Y Tsutsumi, S Nakagawa, J Miyazaki, H Kitamura, T Mayumi

CELL TRANSPLANTATION　Vol. 11　No. 8　p. 787-797　2002　Research paper (scientific journal)