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Yoshioka Yasuo

吉岡　靖雄

Institute for Open and Transdisciplinary Research Initiatives, Specially Appointed Professor (Full Time)

Education

  • 2001/04 - 2004/03, Osaka University, Graduate School of Pharmaceutical Sciences, Applied Biopharmaceutical Sciences
  • 1999/04 - 2001/03, Osaka University, Graduate School of Pharmaceutical Sciences, Applied Biopharmaceutical Sciences
  • - 2000, Osaka University, Graduate School, Division of Food and Medical Sciences
  • 1995/04 - 1999/03, Osaka University, School of Pharmaceutical Sciences

Research History

  • 2020/04 - Present, Osaka University, Research Institute for Microbial Diseases
  • 2015/01 - Present, Osaka University, Research Institute for Microbial Diseases
  • 2012/02 - 2014/12, Osaka University, Graduate School of Pharmaceutical Sciences
  • 2011/04 - 2012/01, 大阪大学臨床医工学融合研究教育センター 特任准教授（常勤）
  • 2006/04 - 2011/03, 大阪大学臨床医工学融合研究教育センター 特任講師（常勤）
  • 2004/04 - 2006/03, 国立医薬品食品衛生研究所食品部 研究員

Research Areas

  • Life sciences, Virology
  • Life sciences, Immunology
  • Life sciences, Pharmacology
  • Life sciences, Pharmaceuticals - health and biochemistry
  • Life sciences, Clinical pharmacy

Professional Memberships

  • THE JAPANESE SOCIETY FOR VACCINOLOGY
  • JAPANESE COSMETIC SCIENCE SOCIETY
  • 日本免疫毒性学会
  • THE JAPANESE SOCIETY OF TOXICOLOGY
  • THE PHARMACEUTICAL SOCIETY OF JAPAN
  • THE JAPAN SOCIETY OF DRUG DELIVERY SYSTEM
  • THE JAPANESE SOCIETY FOR IMMUNOLOGY

Papers

  • Humoral and cellular immune responses to COVID-19 mRNA vaccines in immunosuppressed liver transplant recipients., Takuto Nogimori,Yuta Nagatsuka,Shogo Kobayashi,Hirotomo Murakami,Yuji Masuta,Koichiro Suzuki,Yoshito Tomimaru,Takehiro Noda,Hirofumi Akita,Shokichi Takahama,Yasuo Yoshioka,Yuichiro Doki,Hidetoshi Eguchi,Takuya Yamamoto, Communications medicine, Vol. 4, No. 1, p. 30-30, 2024/02/26
  • CpG ODN enhances the efficacy of F protein vaccine against respiratory syncytial virus infection in the upper respiratory tract via CD4+ T cells., Eigo Kawahara,Shinya Yamamoto,Takehiko Shibata,Toshiro Hirai,Yasuo Yoshioka, Biochemical and biophysical research communications, Vol. 686, p. 149143-149143, 2023/12/17
  • Intranasal immunization with an RBD-hemagglutinin fusion protein harnesses preexisting immunity to enhance antigen-specific responses., Atsushi Kawai,Nagisa Tokunoh,Eigo Kawahara,Shigeyuki Tamiya,Shinya Okamura,Chikako Ono,Jessica Anindita,Hiroki Tanaka,Hidetaka Akita,Sho Yamasaki,Jun Kunisawa,Toru Okamoto,Yoshiharu Matsuura,Toshiro Hirai,Yasuo Yoshioka, The Journal of clinical investigation, Vol. 133, No. 23, 2023/12/01
  • SARS-CoV-2に対する有効なCTL反応を効果的に誘導するためのエピトープ選択法の樹立, 升田 雄士,野木森 拓人,西山 紋恵,鈴木 孝一朗,吉岡 靖雄,高濱 正吉,山本 拓也, 臨床とウイルス, 日本臨床ウイルス学会, Vol. 51, No. 3, p. 160-160, 2023/09
  • Upregulation of Robo4 expression by SMAD signaling suppresses vascular permeability and mortality in endotoxemia and COVID-19 models, Maaya Morita,Aki Yoneda,Nagisa Tokunoh,Tatsumi Masaki,Keisuke Shirakura,Mayumi Kinoshita,Rina Hashimoto,Naoya Shigesada,Junya Takahashi,Masashi Tachibana,Shota Tanaka,Masanori Obana,Nobumasa Hino,Masahito Ikawa,Kazutake Tsujikawa,Chikako Ono,Yoshiharu Matsuura,Hiroyasu Kidoya,Nobuyuki Takakura,Yoshiaki Kubota,Takefumi Doi,Kazuo Takayama,Yasuo Yoshioka,Yasushi Fujio,Yoshiaki Okada, Proceedings of the National Academy of Sciences, Proceedings of the National Academy of Sciences, Vol. 120, No. 3, 2023/01/17
  • Functional changes in cytotoxic CD8+ T-cell cross-reactivity against the SARS-CoV-2 Omicron variant after mRNA vaccination, Takuto Nogimori,Koichiro Suzuki,Yuji Masuta,Ayaka Washizaki,Mika Yagoto,Mami Ikeda,Yuki Katayama,Hidenori Kanda,Minoru Takada,Shohei Minami,Takeshi Kobayashi,Shokichi Takahama,Yasuo Yoshioka,Takuya Yamamoto, Frontiers in Immunology, Frontiers Media SA, Vol. 13, p. 1081047-1081047, 2023/01/04
  • Non-glycosylated G protein with CpG ODN provides robust protection against respiratory syncytial virus without inducing eosinophilia., Eigo Kawahara,Takehiko Shibata,Toshiro Hirai,Yasuo Yoshioka, Frontiers in immunology, Vol. 14, p. 1282016-1282016, 2023
  • Efficient antigen delivery by dendritic cell-targeting peptide via nucleolin confers superior vaccine effects in mice, Teppei Matsuda,Kazuki Misato,Shigeyuki Tamiya,Yasuhiro Akeda,Ikuhiko Nakase,Etsushi Kuroda,Shokichi Takahama,Motohiro Nonaka,Takuya Yamamoto,Michiko N. Fukuda,Yasuo Yoshioka, iScience, Elsevier BV, Vol. 25, No. 11, p. 105324-105324, 2022/11
  • Elucidation of the role of nucleolin as a cell surface receptor for nucleic acid-based adjuvants, Satoki Kitagawa,Teppei Matsuda,Ayaka Washizaki,Hirotomo Murakami,Takuya Yamamoto,Yasuo Yoshioka, npj Vaccines, Springer Science and Business Media LLC, Vol. 7, No. 1, p. 115-115, 2022/10/06
  • SARS-CoV-2 disrupts respiratory vascular barriers by suppressing Claudin-5 expression, Rina Hashimoto,Junya Takahashi,Keisuke Shirakura,Risa Funatsu,Kaori Kosugi,Sayaka Deguchi,Masaki Yamamoto,Yugo Tsunoda,Maaya Morita,Kosuke Muraoka,Masato Tanaka,Tomoaki Kanbara,Shota Tanaka,Shigeyuki Tamiya,Nagisa Tokunoh,Atsushi Kawai,Masahito Ikawa,Chikako Ono,Keisuke Tachibana,Masuo Kondoh,Masanori Obana,Yoshiharu Matsuura,Akihiro Ohsumi,Takeshi Noda,Takuya Yamamoto,Yasuo Yoshioka,Yu-suke Torisawa,Hiroshi Date,Yasushi Fujio,Miki Nagao,Kazuo Takayama,Yoshiaki Okada, Science Advances, American Association for the Advancement of Science (AAAS), Vol. 8, No. 38, 2022/09/23
  • mRNA vaccine induces cytotoxic CD8+ T-cell cross-reactivity against SARS-CoV-2 Omicron variant and regulates COVID-19 severity, Takuto Nogimori,Koichiro Suzuki,Yuji Masuta,Mika Yagoto,Mami Ikeda,Yuki Katayama,Ayaka Washizaki,Hidenori Kanda,Minoru Takada,Shohei Minami,Takeshi Kobayashi,Shokichi Takahama,Yasuo Yoshioka,Takuya Yamamoto, Research Square Platform LLC, 2022/04/11
  • 免疫抑制的な腫瘍内微小環境を有する腫瘍への効果的ながん免疫療法構築に向けた基礎的研究, 宗像 理紗,青枝 大貴,小山 正平,小俣 大樹,丸山 保,鈴木 悠乃,萩原 芙美子,岡田 欣晃,吉岡 靖雄,鈴木 亮, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 142年会, p. 27J-am03, 2022/03
  • Vaccine using community-acquired respiratory distress syndrome toxin as an antigen against Mycoplasma pneumoniae in mice, Eisuke Yoshikawa,Shigeyuki Tamiya,Yuji Inoue,Koichiro Suzuki,Yasuo Yoshioka, Biochemical and Biophysical Research Communications, Elsevier BV, Vol. 594, p. 81-87, 2022/02
  • Considerations of CD8+ T Cells for Optimized Vaccine Strategies Against Respiratory Viruses., Toshiro Hirai,Yasuo Yoshioka, Frontiers in immunology, Vol. 13, p. 918611-918611, 2022
  • Neutrophil-Mediated Lung Injury Both via TLR2-Dependent Production of IL-1α and IL-12 p40, and TLR2-Independent CARDS Toxin after Mycoplasma pneumoniae Infection in Mice, Shigeyuki Tamiya,Eisuke Yoshikawa,Monami Ogura,Etsushi Kuroda,Koichiro Suzuki,Yasuo Yoshioka, Microbiology Spectrum, American Society for Microbiology, Vol. 9, No. 3, 2021/12/22
  • Synergistic effect of non-neutralizing antibodies and interferon-γ for cross-protection against influenza, Meito Shibuya,Shigeyuki Tamiya,Atsushi Kawai,Toshiro Hirai,Mark S. Cragg,Yasuo Yoshioka, iScience, Vol. 24, No. 10, 2021/09
  • The potential of neuraminidase as an antigen for nasal vaccines to increase cross-protection against influenza viruses, Atsushi Kawai,Yasuyuki Yamamoto,Takuto Nogimori,Kohei Takeshita,Takuya Yamamoto,Yasuo Yoshioka, Journal of Virology, American Society for Microbiology, Vol. 95, No. 20, 2021/08/11
  • Nasal-subcutaneous prime-boost regimen for inactivated whole-virus influenza vaccine efficiently protects mice against both upper and lower respiratory tract infections., Meito Shibuya,Shigeyuki Tamiya,Atsushi Kawai,Yasuo Yoshioka, Biochemical and biophysical research communications, Vol. 554, p. 166-172, 2021/05/21
  • HDAC inhibitor, MS-275, increases vascular permeability by suppressing Robo4 expression in endothelial cells, Taito Kashio,Keisuke Shirakura,Mayumi Kinoshita,Maaya Morita,Ryosuke Ishiba,Kosuke Muraoka,Tomoaki Kanbara,Masato Tanaka,Risa Funatsu,Nobumasa Hino,Shohei Koyama,Ryo Suzuki,Yasuo Yoshioka,Taiki Aoshi,Takefumi Doi,Yoshiaki Okada, Tissue Barriers, Informa UK Limited, Vol. 9, No. 3, p. 1911195-1911195, 2021/05/06
  • Susceptibility Analysis in Several Mouse Strains Reveals Robust T-Cell Responses After Mycoplasma pneumoniae Infection in DBA/2 Mice, Shigeyuki Tamiya,Eisuke Yoshikawa,Koichiro Suzuki,Yasuo Yoshioka, Frontiers in Cellular and Infection Microbiology, Frontiers Media SA, Vol. 10, p. 602453-602453, 2021/01/13
  • Lipid Nanoparticle Acts as a Potential Adjuvant for Influenza Split Vaccine without Inducing Inflammatory Responses, Shirai S,Kawai A,Shibuya M,Munakata L,Omata D,Suzuki R,Yoshioka Y, Vaccines (Basel), Vol. 8, No. 3, 2020/08
  • Vaccination using inactivated Mycoplasma pneumoniae induces detrimental infiltration of neutrophils after subsequent infection in mice, Tamiya S,Yoshikawa E,Ogura O,Kuroda E,Suzuki K,Yoshioka Y, Vaccine, Vol. 38, No. 32, p. 4979-4987, 2020/07
  • Vaccine effect of recombinant single-chain hemagglutinin protein as an antigen, Kawai A,Yamamoto Y,Yoshioka Y, Heliyon, Vol. 6, No. 6, 2020/06
  • Murine cross-reactive non-neutralizing polyclonal IgG1 antibodies induced by influenza vaccine inhibit the cross-protective effect of IgG2 against heterologous virus in mice, Shibuya M,Aoshi T,Kuroda E,Yoshioka Y, J Virol., Vol. 94, No. 12, p. 00323-00330, 2020/06
  • Lipid Nanoparticles Potentiate CpG-Oligodeoxynucleotide-Based Vaccine for Influenza Virus, Seiki Shirai,Meito Shibuya,Atsushi Kawai,Shigeyuki Tamiya,Lisa Munakata,Daiki Omata,Ryo Suzuki,Taiki Aoshi,Yasuo Yoshioka, Frontiers in Immunology, Frontiers Media SA, Vol. 10, 2020/01/09
  • Ephrin type-A receptor 2 on tumor-derived exosomes enhances angiogenesis through the activation of MAPK signaling., Yamashita T, Kamada H, Kanasaki S, Nagano K, Inoue M, Higashisaka K, Yoshioka Y, Tsutsumi Y, Tsunoda S, Pharmazie, Vol. 74, No. 10, p. 614-619, 2019/11
  • Lipid nanoparticles of Type-A CpG D35 suppress tumor growth by changing tumor immune-microenvironment and activate CD8 T cells in mice, Lisa Munakata,Yoshihiko Tanimoto,Akio Osa,Jie Meng,Yasunari Haseda,Yujiro Naito,Hirotomo Machiyama,Atsushi Kumanogoh,Daiki Omata,Kazuo Maruyama,Yasuo Yoshioka,Yoshiaki Okada,Shohei Koyama,Ryo Suzuki,Taiki Aoshi, Journal of Controlled Release, Elsevier BV, Vol. 313, p. 106-119, 2019/11
  • Peptides with the multibasic cleavage site of the hemagglutinin from highly pathogenic influenza viruses act as cell-penetrating via binding to heparan sulfate and neuropilins., Yamamoto Y,Tamiya S,Shibuya M,Nakase I,Yoshioka Y, Biochem Biophys Res Commun, Vol. 512, No. 3, p. 453-459, 2019/05
  • Autophagy is a new protective mechanism against the cytotoxicity of platinum nanoparticles in human trophoblasts., Nakashima A,Higashisaka K,Kusabiraki T,Aoki A,Ushijima A,Ono Y,Tsuda S,Shima T,Yoshino O,Nagano K,Yoshioka Y,Tsutsumi Y,Saito S, Sci Rep, Vol. 9, No. 1, p. 5478-5478, 2019/04
  • Neutrophil depletion exacerbates pregnancy complications, including placental damage, induced by silica nanoparticles in mice., Higashisaka K,Nakashima A,Iwahara Y,Aoki A,Nakayama M,Yanagihara I,Lin Y,Nagano K,Tsunoda S,Saito S,Yoshioka Y,Tsutsumi Y, Front Immunol, Vol. 9, 2018/08
  • Carbonate apatite nanoparticles act as potent vaccine adjuvant delivery vehicles by enhancing cytokine production induced by encapsulated cytosine-phosphate-guanine oligodeoxynucleotides, Hideki Takahashi,Kazuki Misato,Taiki Aoshi,Yasuyuki Yamamoto,Yui Kubota,Xin Wu,Etsushi Kuroda,Ken J. Ishii,Hirofumi Yamamoto,Yasuo Yoshioka, Frontiers in Immunology, Frontiers Media S.A., Vol. 9, No. APR, 2018/04/18
  • 高活性型XCL1/lymphotactinによる抗原特異的メモリーCTLの効率的な誘導, 亀井 萌百,松尾 一彦,北畑 孝祐,吉岡 靖雄,義江 修,中山 隆志, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 138年会, No. 3, p. 168-168, 2018/03
  • Intracellular trafficking of particles inside endosomal vesicles is regulated by particle size, Michihiko Aoyama,Yasuo Yoshioka,Yoshiyuki Arai,Haruna Hirai,Rio Ishimoto,Kazuya Nagano,Kazuma Higashisaka,Takeharu Nagai,Yasuo Tsutsumi, JOURNAL OF CONTROLLED RELEASE, ELSEVIER SCIENCE BV, Vol. 260, p. 183-193, 2017/08
  • Permeability of skin to silver nanoparticles after epidermal skin barrier disruption in rats, Kuwagata Makiko,Kumagai Fumiaki,Saito Yoshiaki,Higashisaka Kazuma,Yoshioka Yasuo,Tsutsumi Yasuo, Fundamental Toxicological Sciences, The Japanese Society of Toxicology, Vol. 4, No. 3, p. 109-119, 2017/06
  • Modifying the Surface of Silica Nanoparticles with Amino or Carboxyl Groups Decreases Their Cytotoxicity to Parenchymal Hepatocytes, Takashi Nagano,Kazuya Nagano,Hiromi Nabeshi,Tokuyuki Yoshida,Haruhiko Kamada,Shin-ichi Tsunoda,Jian-Qing Gao,Kazuma Higashisaka,Yasuo Yoshioka,Yasuo Tsutsumi, BIOLOGICAL & PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOC JAPAN, Vol. 40, No. 5, p. 726-728, 2017/05
  • Human scavenger receptor A1-mediated inflammatory response to silica particle exposure is size specific, Nobuo Nishijima,Toshiro Hirai,Kazuki Misato,Michihiko Aoyama,Etsushi Kuroda,Ken J. Ishii,Kazuma Higashisaka,Yasuo Yoshioka,Yasuo Tsutsumi, Frontiers in Immunology, Frontiers Research Foundation, Vol. 8, No. 379, 2017/04/03
  • Moesin is activated in cardiomyocytes in experimental autoimmune myocarditis and mediates tissue restoration with protrusion formation, Mitsuhara Yusuke,Miyawaki Akimitsu,Orimoto Aya,Nakayasu Yusuke,Tsunoda Shin-ichi,Obana Masanori,Maeda Makiko,Nakayama Hiroyuki,Yoshioka Yasuo,Tsutsumi Yasuo,Fujio Yasushi, JOURNAL OF PHARMACOLOGICAL SCIENCES, Vol. 133, No. 3, 2017/03
  • Cellular internalization, transcellular transport, and cellular effects of silver nanoparticles in polarized Caco-2 cells following apical or basolateral exposure, Shunji Imai,Yuki Morishita,Tomoyuki Hata,Masuo Kondoh,Kiyohito Yagi,Jian-Qing Gao,Kazuya Nagano,Kazuma Higashisaka,Yasuo Yoshioka,Yasuo Tsutsumi, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC ELSEVIER SCIENCE, Vol. 484, No. 3, p. 543-549, 2017/03
  • Identifying a size-specific hazard of silica nanoparticles after intravenous administration and its relationship to the other hazards that have negative correlations with the particle size in mice, Takayuki Handa,Toshiro Hirai,Natsumi Izumi,Shun-ichi Eto,Shin-ichi Tsunoda,Kazuya Nagano,Kazuma Higashisaka,Yasuo Yoshioka,Yasuo Tsutsumi, NANOTECHNOLOGY, IOP PUBLISHING LTD, Vol. 28, No. 13, 2017/02
  • Hepatotoxicity, nephrotoxicity, and drug/chemical interaction toxicity of platinum nanoparticles in mice, K. Isoda,T. Daibo,K. Yushina,Y. Yoshioka,Y. Tsutsumi,Y. Akimoto,H. Kawakami,Y. Taira,I. Taira,R. Yanoshita,T. Nishimura,I. Ishida, PHARMAZIE, GOVI-VERLAG PHARMAZEUTISCHER VERLAG GMBH, Vol. 72, No. 1, p. 10-16, 2017/01
  • Potential Suppressive Effects of Two C60 Fullerene Derivatives on Acquired Immunity, Toshiro Hirai,Yasuo Yoshioka,Asako Udaka,Eiichiro Uemura,Tomoyuki Ohe,Hisae Aoshima,Jian-Qing Gao,Ken Kokubo,Takumi Oshima,Kazuya Nagano,Kazuma Higashisaka,Tadahiko Mashino,Yasuo Tsutsumi, Nanoscale Research Letters, Springer New York LLC, Vol. 11, No. 1, 2016/12/01
  • Clusterin in the protein corona plays a key role in the stealth effect of nanoparticles against phagocytes, Michihiko Aoyama,Katutomo Hata,Kazuma Higashisaka,Kazuya Nagano,Yasuo Yoshioka,Yasuo Tsutsumi, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC ELSEVIER SCIENCE, Vol. 480, No. 4, p. 690-695, 2016/11
  • Distribution of Silver Nanoparticles to Breast Milk and Their Biological Effects on Breast-Fed Offspring Mice, Yuki Morishita,Yasuo Yoshioka,Yuya Takimura,Yuki Shimizu,Yuki Namba,Nao Nojiri,Takuya Ishizaka,Keizo Takao,Fumiyoshi Yamashita,Kazuhiro Takuma,Yukio Ago,Kazuya Nagano,Yohei Mukai,Haruhiko Kamada,Shin-ichi Tsunoda,Shigeru Saito,Toshio Matsuda,Mitsuru Hashida,Tsuyoshi Miyakawa,Kazuma Higashisaka,Yasuo Tsutsumi, ACS NANO, AMER CHEMICAL SOC, Vol. 10, No. 9, p. 8180-8191, 2016/09
  • Metal nanoparticles in the presence of lipopolysaccharides trigger the onset of metal allergy in mice, Toshiro Hirai,Yasuo Yoshioka,Natsumi Izumi,Ko-ichi Ichihashi,Takayuki Handa,Nobuo Nishijima,Eiichiro Uemura,Ko-ichi Sagami,Hideki Takahashi,Manami Yamaguchi,Kazuya Nagano,Yohei Mukai,Haruhiko Kamada,Shin-ichi Tsunoda,Ken J. Ishii,Kazuma Higashisaka,Yasuo Tsutsumi, NATURE NANOTECHNOLOGY, NATURE PUBLISHING GROUP, Vol. 11, No. 9, p. 808-816, 2016/09
  • Moesin is activated in cardiomyocytes in experimental autoimmune myocarditis and mediates cytoskeletal reorganization with protrusion formation, Akimitsu Miyawaki,Yusuke Mitsuhara,Aya Orimoto,Yusuke Nakayasu,Shin-ichi Tsunoda,Masanori Obana,Makiko Maeda,Hiroyuki Nakayama,Yasuo Yoshioka,Yasuo Tsutsumi,Yasushi Fujio, AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, AMER PHYSIOLOGICAL SOC, Vol. 311, No. 2, p. H476-H486, 2016/08
  • High-dose cutaneous exposure to mite allergen induces IgG-mediated protection against anaphylaxis, T. Hirai,Y. Yoshioka,H. Takahashi,T. Handa,N. Izumi,T. Mori,E. Uemura,N. Nishijima,K. Sagami,M. Yamaguchi,S. Eto,K. Nagano,H. Kamada,S. Tsunoda,K. J. Ishii,K. Higashisaka,Y. Tsutsumi, CLINICAL AND EXPERIMENTAL ALLERGY, WILEY-BLACKWELL, Vol. 46, No. 7, p. 992-1003, 2016/07
  • Relationship between size and surface modification of silica particles and enhancement and suppression of inflammatory cytokine production by lipopolysaccharide- or peptidoglycan-stimulated RAW264.7 macrophages, Eiichiro Uemura,Yasuo Yoshioka,Toshiro Hirai,Takayuki Handa,Kazuya Nagano,Kazuma Higashisaka,Yasuo Tsutsumi, JOURNAL OF NANOPARTICLE RESEARCH, SPRINGER, Vol. 18, No. 6, 2016/06
  • Biocompatibility of nanomaterials, Yoshioka Y,Higashisaka K,Tsutsumi Y, Nanomaterials in Pharmacology, 2016/01
  • Elucidation of immunotoxicity of nanoparticles for developing the sustainable nanotechnology, Yoshioka Y,Higashisaka K,Tsutsumi Y, 2015/12
  • A Novel Bispecific Antibody against Human CD3 and Ephrin Receptor A10 for Breast Cancer Therapy, Shintaro Taki,Haruhiko Kamada,Masaki Inoue,Kazuya Nagano,Yohei Mukai,Kazuma Higashisaka,Yasuo Yoshioka,Yasuo Tsutsumi,Shin-ichi Tsunoda, PLOS ONE, PUBLIC LIBRARY SCIENCE, Vol. 10, No. 12, 2015/12
  • Hydroxylated fullerene: a potential antiinflammatory and antioxidant agent for preventing mouse preterm birth, Tetsu Wakimoto,Kaoru Uchida,Kazuya Mimura,Takeshi Kanagawa,Tzvetozar Roussev Mehandjiev,Hisae Aoshima,Ken Kokubo,Nobuaki Mitsuda,Yasuo Yoshioka,Yasuo Tsutsumi,Tadashi Kimura,Itaru Yanagihara, AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, MOSBY-ELSEVIER, Vol. 213, No. 5, 2015/11
  • Potential hazards of skin exposure to nanoparticles, Toshiro Hirai,Yasuo Yoshioka,Kazuma Higashisaka,Yasuo Tsutsumi, Biological Effects of Fibrous and Particulate Substances, Springer Japan, p. 123-135, 2015/10/26
  • Biodistribution and therapeutic effects of a monoclonal antibody against Eph receptor A10 in a breast cancer xenograft model, Kazuya Nagano,Yuka Maeda,Takuya Yamashita,Yohei Mukai,Haruhiko Kamada,Kazuma Higashisaka,Yasuo Yoshioka,Yasuo Tsutsumi,Shin-ichi Tsunoda, CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, Vol. 75, 2015/08
  • Identification and evaluation of metastasis-related proteins, oxysterol binding protein-like 5 and calumenin, in lung tumors, Kazuya Nagano,Sunao Imai,Xiluli Zhao,Takuya Yamashita,Yasuo Yoshioka,Yasuhiro Abe,Yohei Mukai,Haruhiko Kamada,Shinsaku Nakagawa,Yasuo Tsutsumi,Shin-Ichi Tsunoda, International Journal of Oncology, Spandidos Publications, Vol. 47, No. 1, p. 195-203, 2015/07/01
  • 脆弱な個体をも対象としたナノ安全科学研究～Sustainable Nanotechnologyを目指して～, 吉岡 靖雄,東阪 和馬,堤 康央, 2015/07
  • 金属系ナノマテリアルのナノ安全科学研究～Sustainable Nanotechnologyを目指して～, 吉岡 靖雄,東阪 和馬,堤 康央, 2015/07
  • Understanding of immunotoxicity of engineered nanomaterials for the sustainable nanotechnology, Yoshioka Y,Tsutsumi Y, 2015/06
  • Sustainable Nanotechnologyを目指したナノ安全科学研究, 吉岡 靖雄,東阪 和馬,堤 康央, 2015/06
  • Cutaneous exposure to agglomerates of silica nanoparticles and allergen results in IgE-biased immune response and increased sensitivity to anaphylaxis in mice, Toshiro Hirai,Yasuo Yoshioka,Hideki Takahashi,Ko-ichi Ichihashi,Asako Udaka,Takahide Mori,Nobuo Nishijima,Tokuyuki Yoshida,Kazuya Nagano,Haruhiko Kamada,Shin-ichi Tsunoda,Tatsuya Takagi,Ken J. Ishii,Hiromi Nabeshi,Tomoaki Yoshikawa,Kazuma Higashisaka,Yasuo Tsutsumi, PARTICLE AND FIBRE TOXICOLOGY, BIOMED CENTRAL LTD, Vol. 12, No. 1, 2015/06
  • Protein corona changes mediated by surface modification of amorphous silica nanoparticles suppress acute toxicity and activation of intrinsic coagulation cascade in mice, Tokuyuki Yoshida,Yasuo Yoshioka,Yuki Morishita,Michihiko Aoyama,Saeko Tochigi,Toshiro Hirai,Kota Tanaka,Kazuya Nagano,Haruhiko Kamada,Shin-ichi Tsunoda,Hiromi Nabeshi,Tomoaki Yoshikawa,Kazuma Higashisaka,Yasuo Tsutsumi, NANOTECHNOLOGY, IOP PUBLISHING LTD, Vol. 26, No. 24, 2015/06
  • ナノ粒子曝露に着眼したアレルギー発症要因の理解に向けて, 吉岡 靖雄,堤 康央, 2015/05
  • Identification and evaluation of metastasis-related proteins, oxysterol binding protein like 5 and calumenin, in lung tumor., Nagano K,Imai S,Zhao X,Yoshida Y,Yamashita T,Yoshioka Y,Abe Y,Mukai Y,Kamada H,Nakagawa S,Tsutsumi Y,Tsunoda S, Int. J. Oncol., 2015/05
  • Short-term changes in intracellular ROS localisation after the silver nanoparticles exposure depending on particle size, Akira Onodera,Fumiko Nishiumi,Kisa Kakiguchi,Atsushi Tanaka,Nami Tanabe,Aki Honma,Katsutoshi Yayama,Yasuo Yoshioka,Kumiko Nakahira,Shigenobu Yonemura,Itaru Yanagihara,Yasuo Tsutsumi,Yuichi Kawai, Toxicology Reports, Elsevier Inc., Vol. 2, p. 574-579, 2015/01/01
  • Silica nanoparticle-induced toxicity in mouse lung and liver imaged by electron microscopy, Isoda Katsuhiro,Kondoh Masuo,Yoshioka Yasuo,Tsutsumi Yasuo,Imazawa Takayoshi,Nishimura Tetsuji,Ishida Isao,Yagi Kiyohito, Fundamental Toxicological Sciences, The Japanese Society of Toxicology, Vol. 2, No. 1, p. 19-23, 2015/01
  • Aminopeptidase P3, a new member of the TNF-TNFR2 signaling complex, induces phosphorylation of JNK1 and JNK2, Masaki Inoue,Haruhiko Kamada,Yasuhiro Abe,Kazuma Higashisaka,Kazuya Nagano,Yohei Mukai,Yasuo Yoshioka,Yasuo Tsutsumi,Shin-Ichi Tsunoda, Journal of Cell Science, Company of Biologists Ltd, Vol. 128, No. 4, p. 656-669, 2015
  • Generation and characterization of a bispecific diabody targeting both EPH receptor A10 and CD3, Haruhiko Kamada,Shintaro Taki,Kazuya Nagano,Masaki Inoue,Daisuke Ando,Yohei Mukai,Kazuma Higashisaka,Yasuo Yoshioka,Yasuo Tsutsumi,Shin-ichi Tsunoda, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC ELSEVIER SCIENCE, Vol. 456, No. 4, p. 908-912, 2015/01
  • Evaluation of silica nanoparticle binding to major human blood proteins, Katsutomo Hata,Kazuma Higashisaka,Kazuya Nagano,Yohei Mukai,Haruhiko Kamada,Shin-ichi Tsunoda,Yasuo Yoshioka,Yasuo Tsutsumi, NANOSCALE RESEARCH LETTERS, SPRINGER, Vol. 9, 2014/12
  • Size and surface modification of amorphous silica particles determine their effects on the activity of human CYP3A4 in vitro, Shunji Imai,Yasuo Yoshioka,Yuki Morishita,Tokuyuki Yoshida,Miyuki Uji,Kazuya Nagano,Yohei Mukai,Haruhiko Kamada,Shin-ichi Tsunoda,Kazuma Higashisaka,Yasuo Tsutsumi, NANOSCALE RESEARCH LETTERS, SPRINGER, Vol. 9, 2014/12
  • Neutrophilia due to silica nanoparticles induces release of double-stranded DNA., Higashisaka K,Kunieda A,Iwahara Y,Tanaka K,Nagano K,Mukai Y,Kamada H,Tsunoda S,Yoshioka Y,Tsutsumi Y, Journal of Nanomedicine & Nanotechnology., 2014/10
  • The absorption, distribution, metabolism, and excretion profile of nanoparticles., Yoshioka Y,Higashisaka K,Tsunoda S,Tsutsumi Y, Engineered Cell Manipulation for Biomedical Application., 2014/09
  • Intestinal absorption and biological effects of orally administered amorphous silica particles, Tokuyuki Yoshida,Yasuo Yoshioka,Hideki Takahashi,Kazuki Misato,Takahide Mori,Toshiro Hirai,Kazuya Nagano,Yasuhiro Abe,Yohei Mukai,Haruhiko Kamada,Shin-ichi Tsunoda,Hiromi Nabeshi,Tomoaki Yoshikawa,Kazuma Higashisaka,Yasuo Tsutsumi, NANOSCALE RESEARCH LETTERS, SPRINGER, Vol. 9, 2014/09
  • Ephrin receptor A10 is a promising drug target potentially useful for breast cancers including triple negative breast cancers, Kazuya Nagano,Yuka Maeda,So-ichiro Kanasaki,Takanobu Watanabe,Takuya Yamashita,Masaki Inoue,Kazuma Higashisaka,Yasuo Yoshioka,Yasuhiro Abe,Yohei Mukai,Haruhiko Kamada,Yasuo Tsutsumi,Shin-ichi Tsunoda, JOURNAL OF CONTROLLED RELEASE, ELSEVIER SCIENCE BV, Vol. 189, p. 72-79, 2014/09
  • Eph receptor A10 has a potential as a target for a prostate cancer therapy, Kazuya Nagano,Takuya Yamashita,Masaki Inoue,Kazuma Higashisaka,Yasuo Yoshioka,Yasuhiro Abe,Yohei Mukai,Haruhiko Kamada,Yasuo Tsutsumi,Shin-ichi Tsunoda, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC ELSEVIER SCIENCE, Vol. 450, No. 1, p. 545-549, 2014/07
  • Recent Topics on Development of Nanomaterials and Nano-Safety Science Foreword, Yasuo Yoshioka,Yasuo Tsutsumi, YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, PHARMACEUTICAL SOC JAPAN, Vol. 134, No. 6, p. 721-722, 2014/06
  • Nano-safety Science for Sustainable Nanotechnology, Yasuo Yoshioka,Yasuo Tsutsumi, YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, PHARMACEUTICAL SOC JAPAN, Vol. 134, No. 6, p. 737-742, 2014/06
  • Polyethyleneimine-coating enhances adenoviral transduction of mesenchymal stem cells, Xinglei Yao,Na Zhou,Li Wan,Xiaodong Su,Zhao Sun,Hiroyuki Mizuguchi,Yasuo Yoshioka,Shinsaku Nakagawa,Robert Chunhua Zhao,Jian-Qing Gao, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC ELSEVIER SCIENCE, Vol. 447, No. 3, p. 383-387, 2014/05
  • 経皮曝露に着目したナノマテリアルの安全性評価, 東阪和馬,吉岡靖雄,堤 康央, ファームテックジャパン, 2014/05
  • The effects of silica nanoparticles on allergic diseases : For the development of nanomaterials with efficacy and safety, Vol. 61, No. 4, p. 352-356, 2014/04
  • Proteomics approach for searching diagnostic markers of Parkinson's disease., MISATO Kazuki,MUKAI Yohei,HIGASHISAKA Kazuma,YOSHIOKA Yasuo,NAGANO Kazuya,KAMADA Haruhiko,FUJIO Yasushi,MOCHIZUKI Hideki,TSUNODA Shin-ichi,TSUTSUMI Yasuo, Abstracts for Annual Meeting of Japanese Proteomics Society, Japanese Proteomics Society (Japan Human Proteome Organisation), Vol. 2014, p. 73-73, 2014
  • Asian Dust Particles Induce Macrophage Inflammatory Responses via Mitogen-Activated Protein Kinase Activation and Reactive Oxygen Species Production, Kazuma Higashisaka,Maho Fujimura,Mayu Taira,Tokuyuki Yoshida,Shin-ichi Tsunoda,Takashi Baba,Nobuyasu Yamaguchi,Hiromi Nabeshi,Tomoaki Yoshikawa,Masao Nasu,Yasuo Yoshioka,Yasuo Tsutsumi, JOURNAL OF IMMUNOLOGY RESEARCH, HINDAWI PUBLISHING CORPORATION, 2014
  • Expression of Eph receptor A10 is correlated with lymph node metastasis and stage progression in breast cancer patients, Kazuya Nagano,So-ichiro Kanasaki,Takuya Yamashita,Yuka Maeda,Masaki Inoue,Kazuma Higashisaka,Yasuo Yoshioka,Yasuhiro Abe,Yohei Mukai,Haruhiko Kamada,Yasuo Tsutsumi,Shin-ichi Tsunoda, CANCER MEDICINE, WILEY-BLACKWELL, Vol. 2, No. 6, p. 972-977, 2013/12
  • Epidermal growth factor receptor localized to exosome membranes as a possible biomarker for lung cancer diagnosis, T. Yamashita,H. Kamada,S. Kanasaki,Y. Maeda,K. Nagano,Y. Abe,M. Inoue,Y. Yoshioka,Y. Tsutsumi,S. Katayama,M. Inoue,Shin-Ichi Tsunoda, Pharmazie, Vol. 68, No. 12, p. 969-973, 2013/12
  • Proteome profiling and detecting method of lung cancer cell-derived exosomes as tumor biomarkers., Haruhiko Kamada,Takuya Yamashita,Masaki Inoue,Kazuya Nagano,Sumie Katayama,Yohei Mukai,Yasuo Yoshioka,Kazuma Higashisaka,Yasuo Tsutsumi,Shin-ichi Tsunoda, MOLECULAR CANCER THERAPEUTICS, AMER ASSOC CANCER RESEARCH, Vol. 12, No. 11, 2013/11
  • Anti-EphA10 monoclonal antibody is a potential therapy against EphA10 positive breast cancer., Kazuya Nagano,Yuka Maeda,Takuya Yamashita,Masaki Inoue,Yasuhiro Abe,Yohei Mukai,Haruhiko Kamada,Kazuma Higashisaka,Yasuo Yoshioka,Yasuo Tsutsumi,Shin-ichi Tsunoda, MOLECULAR CANCER THERAPEUTICS, AMER ASSOC CANCER RESEARCH, Vol. 12, No. 11, 2013/11
  • Liver-specific microRNAs as biomarkers of nanomaterial-induced liver damage, Takashi Nagano,Kazuma Higashisaka,Akiyoshi Kunieda,Yuki Iwahara,Kota Tanaka,Kazuya Nagano,Yasuhiro Abe,Haruhiko Kamada,Shin-ichi Tsunoda,Hiromi Nabeshi,Tomoaki Yoshikawa,Yasuo Yoshioka,Yasuo Tsutsumi, NANOTECHNOLOGY, IOP PUBLISHING LTD, Vol. 24, No. 40, 2013/10
  • Acute and chronic nephrotoxicity of platinum nanoparticles in mice, Yoshiaki Yamagishi,Akihiro Watari,Yuya Hayata,Xiangru Li,Masuo Kondoh,Yasuo Yoshioka,Yasuo Tsutsumi,Kiyohito Yagi, NANOSCALE RESEARCH LETTERS, SPRINGER, Vol. 8, 2013/09
  • Intranasal exposure to amorphous nanosilica particles could activate intrinsic coagulation cascade and platelets in mice, Tokuyuki Yoshida,Yasuo Yoshioka,Saeko Tochigi,Toshiro Hirai,Miyuki Uji,Ko-ichi Ichihashi,Kazuya Nagano,Yasuhiro Abe,Haruhiko Kamada,Shin-ichi Tsunoda,Hiromi Nabeshi,Kazuma Higashisaka,Tomoaki Yoshikawa,Yasuo Tsutsumi, PARTICLE AND FIBRE TOXICOLOGY, BIOMED CENTRAL LTD, Vol. 10, 2013/08
  • 経皮吸収性に着目したナノマテリアルの安全性評価研究, 東阪和馬,吉岡靖雄,堤 康央, コスメテックジャパン, 2013/08
  • Mutants of lymphotoxin-alpha with augmented cytotoxic activity via TNFR1 for use in cancer therapy, Tomohiro Morishige,Yasuo Yoshioka,Shogo Narimatsu,Shinji Ikemizu,Shin-ichi Tsunoda,Yasuo Tsutsumi,Yohei Mukai,Naoki Okada,Shinsaku Nakagawa, CYTOKINE, ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, Vol. 61, No. 2, p. 578-584, 2013/02
  • Resent Topics on Development of Nanomaterials and Nano-Safety Science Foreword, Yasuo Yoshioka,Yasuo Tsutsumi, YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, PHARMACEUTICAL SOC JAPAN, Vol. 133, No. 2, p. 149-150, 2013/02
  • Recent Topics about Nano-safety Science and Its Future, Yasuo Yoshioka,Tomoaki Yoshikawa,Hiromi Nabeshi,Yasuo Tsutsumi, YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, PHARMACEUTICAL SOC JAPAN, Vol. 133, No. 2, p. 169-174, 2013/02
  • Robo4 is an effective tumor endothelial marker for antibody-drug conjugates based on the rapid isolation of the anti-Robo4 cell-internalizing antibody, Mai Yoshikawa,Yohei Mukai,Yoshiaki Okada,Yuki Tsumori,Shin-Ichi Tsunoda,Yasuo Tsutsumi,William C. Aird,Yasuo Yoshioka,Naoki Okada,Takefumi Doi,Shinsaku Nakagawa, Blood, American Society of Hematology, Vol. 121, No. 14, p. 2804-2813, 2013
  • Robo4 is an effective tumor endothelial marker for antibody-drug conjugates based on the rapid isolation of the anti-Robo4 cell-internalizing antibody, Mai Yoshikawa,Yohei Mukai,Yoshiaki Okada,Yuki Tsumori,Shin-Ichi Tsunoda,Yasuo Tsutsumi,William C. Aird,Yasuo Yoshioka,Naoki Okada,Takefumi Doi,Shinsaku Nakagawa, Blood, American Society of Hematology, Vol. 121, No. 14, p. 2804-2813, 2013
  • Biochemical and hematologic effects of polyvinylpyrrolidone-wrapped fullerene C60 after oral administration, K. Yamashita,Y. Yoshioka,H. Pan,M. Taira,T. Ogura,T. Nagano,M. Aoyama,K. Nagano,Y. Abe,H. Kamada,S. I. Tsunoda,H. Aoshima,H. Nabeshi,T. Yoshikawa,Y. Tsutsumi, Pharmazie, Vol. 68, No. 1, p. 54-57, 2013/01
  • 安全なナノマテリアルの開発に資するナノ安全科学研究の最前線, 永野貴士,堤 康央,吉岡靖雄, 感染炎症免疫, 2012/12
  • Potential of acute-phase proteins as biomarkers for sub-nano platinum exposure, T. Nagano,Y. Yoshioka,K. Higashisaka,A. Kunieda,K. Hata,K. Nagano,Y. Abe,H. Kamada,S. Tsunoda,H. Nabeshi,T. Yoshikawa,Y. Tsutsumi, PHARMAZIE, GOVI-VERLAG PHARMAZEUTISCHER VERLAG GMBH, Vol. 67, No. 11, p. 958-959, 2012/11
  • Surface modification of amorphous nanosilica particles suppresses nanosilica-induced cytotoxicity, ROS generation, and DNA damage in various mammalian cells, Tokuyuki Yoshida,Yasuo Yoshioka,Keigo Matsuyama,Yasutaro Nakazato,Saeko Tochigi,Toshiro Hirai,Sayuri Kondoh,Kazuya Nagano,Yasuhiro Abe,Haruhiko Kamada,Shin-ichi Tsunoda,Hiromi Nabeshi,Tomoaki Yoshikawa,Yasuo Tsutsumi, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC ELSEVIER SCIENCE, Vol. 427, No. 4, p. 748-752, 2012/11
  • The Safety Assessment of Nanomaterials for Development of Nano-cosmetics, Tokuyuki Yoshida,Yasuo Yoshioka,Yasuo Tsutsumi, YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, PHARMACEUTICAL SOC JAPAN, Vol. 132, No. 11, p. 1231-1236, 2012/11
  • Amorphous silica nanoparticles enhance cross-presentation in murine dendritic cells, Toshiro Hirai,Yasuo Yoshioka,Hideki Takahashi,Ko-ichi Ichihashi,Tokuyuki Yoshida,Saeko Tochigi,Kazuya Nagano,Yasuhiro Abe,Haruhiko Kamada,Shin-ichi Tsunoda,Hiromi Nabeshi,Tomoaki Yoshikawa,Yasuo Tsutsumi, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC ELSEVIER SCIENCE, Vol. 427, No. 3, p. 553-556, 2012/10
  • Hemopexin as biomarkers for analyzing the biological responses associated with exposure to silica nanoparticles, Kazuma Higashisaka,Yasuo Yoshioka,Kohei Yamashita,Yuki Morishita,Huiyan Pan,Toshinobu Ogura,Takashi Nagano,Akiyoshi Kunieda,Kazuya Nagano,Yasuhiro Abe,Haruhiko Kamada,Shin-ichi Tsunoda,Hiromi Nabeshi,Tomoaki Yoshikawa,Yasuo Tsutsumi, NANOSCALE RESEARCH LETTERS, SPRINGER, Vol. 7, 2012/10
  • ナノ安全科学研究の最前線, 吉岡靖雄,堤 康央, CICSJ Bulletin, 2012/09
  • Intravenous Administration of Polyethylene Glycol-Coated (PEGylated) Proteins and PEGylated Adenovirus Elicits an Anti-PEG Immunoglobulin M Response, Taro Shimizu,Masako Ichihara,Yasuo Yoshioka,Tatsuhiro Ishida,Shinsaku Nakagawa,Hiroshi Kiwada, BIOLOGICAL & PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOC JAPAN, Vol. 35, No. 8, p. 1336-1342, 2012/08
  • Optimization and Internalization Mechanisms of PEGylated Adenovirus Vector with Targeting Peptide for Cancer Gene Therapy, Xing-Lei Yao,Yasuo Yoshioka,Gui-Xin Ruan,Yu-Zhe Chen,Hiroyuki Mizuguchi,Yohei Mukai,Naoki Okada,Jian-Qing Gao,Shinsaku Nakagawa, BIOMACROMOLECULES, AMER CHEMICAL SOC, Vol. 13, No. 8, p. 2402-2409, 2012/08
  • Amorphous nanosilica particles induce ROS generation in Langerhans cells, T. Yoshida,T. Yoshikawa,H. Nabeshi,K. Matsuyama,T. Hirai,T. Akase,Y. Yoshioka,N. Itoh,Y. Tsutsumi, PHARMAZIE, GOVI-VERLAG PHARMAZEUTISCHER VERLAG GMBH, Vol. 67, No. 8, p. 740-741, 2012/08
  • Dermal absorption of amorphous nanosilica particles after topical exposure for three days, T. Hirai,T. Yoshikawa,H. Nabeshi,T. Yoshida,T. Akase,Y. Yoshioka,N. Itoh,Y. Tsutsumi, PHARMAZIE, GOVI-VERLAG PHARMAZEUTISCHER VERLAG GMBH, Vol. 67, No. 8, p. 742-743, 2012/08
  • Distribution and histologic effects of intravenously administered amorphous nanosilica particles in the testes of mice, Yuki Morishita,Yasuo Yoshioka,Hiroyoshi Satoh,Nao Nojiri,Kazuya Nagano,Yasuhiro Abe,Haruhiko Kamada,Shin-ichi Tsunoda,Hiromi Nabeshi,Tomoaki Yoshikawa,Yasuo Tsutsumi, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC ELSEVIER SCIENCE, Vol. 420, No. 2, p. 297-301, 2012/04
  • Annexin A4 is a possible biomarker for cisplatin susceptibility of malignant mesothelioma cells, Takuya Yamashita,Kazuya Nagano,So-ichiro Kanasaki,Yuka Maeda,Takeshi Furuya,Masaki Inoue,Hiromi Nabeshi,Tomoaki Yoshikawa,Yasuo Yoshioka,Norio Itoh,Yasuhiro Abe,Haruhiko Kamada,Yasuo Tsutsumi,Shin-ichi Tsunoda, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC ELSEVIER SCIENCE, Vol. 421, No. 1, p. 140-144, 2012/04
  • ナノカーボンDDSの現状とその安全性確保に向けて, 平井敏郎,吉岡靖雄,堤 康央, ドラッグデリバリーシステムの新展開Ⅱ -核酸医薬・抗体医薬・ワクチン医療を支えるDDS技術-, シーエムシー出版, 2012/03
  • Suppression of nanosilica particle–induced inflammation by surface modification of the particles, Morishige T,Yoshioka Y,Inakura H,Tanabe A,Narimatsu S,Yao X,Monobe Y,Imazawa T,Tsunoda S,Tsutsumi Y,Mukai Y,Okada N,Nakagawa S, Arch. Toxicol, 2012/03
  • Rho GDP-dissociation inhibitor alpha is associated with cancer metastasis in colon and prostate cancer, T. Yamashita,T. Okamura,K. Nagano,S. Imai,Y. Abe,H. Nabeshi,T. Yoshikawa,Y. Yoshioka,H. Kamada,Y. Tsutsumi,S. Tsunoda, PHARMAZIE, GOVI-VERLAG PHARMAZEUTISCHER VERLAG GMBH, Vol. 67, No. 3, p. 253-255, 2012/03
  • The Safety Assessment of Nanomaterials in Reproductive Developmental Field, Kohei Yamashita,Yasuo Yoshioka, YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, PHARMACEUTICAL SOC JAPAN, Vol. 132, No. 3, p. 331-335, 2012/03
  • Carbon Nanomaterials: Efficacy and Safety for Nanomedicine, Takuya Yamashita,Kohei Yamashita,Hiromi Nabeshi,Tomoaki Yoshikawa,Yasuo Yoshioka,Shin-ichi Tsunoda,Yasuo Tsutsumi, MATERIALS, MDPI AG, Vol. 5, No. 2, p. 350-363, 2012/02
  • Amorphous silica nanoparticles size-dependently aggravate atopic dermatitis-like skin lesions following an intradermal injection, Toshiro Hirai,Tomoaki Yoshikawa,Hiromi Nabeshi,Tokuyuki Yoshida,Saeko Tochigi,Ko-ichi Ichihashi,Miyuki Uji,Takanori Akase,Kazuya Nagano,Yasuhiro Abe,Haruhiko Kamada,Norio Itoh,Shin-ichi Tsunoda,Yasuo Yoshioka,Yasuo Tsutsumi, PARTICLE AND FIBRE TOXICOLOGY, BIOMED CENTRAL LTD, Vol. 9, 2012/02
  • Amorphous nanosilicas induce consumptive coagulopathy after systemic exposure, Hiromi Nabeshi,Tomoaki Yoshikawa,Keigo Matsuyama,Yasutaro Nakazato,Akihiro Arimori,Masaaki Isobe,Saeko Tochigi,Sayuri Kondoh,Toshiro Hirai,Takanori Akase,Takuya Yamashita,Kohei Yamashita,Tokuyuki Yoshida,Kazuya Nagano,Yasuhiro Abe,Yasuo Yoshioka,Haruhiko Kamada,Takayoshi Imazawa,Norio Itoh,Masuo Kondoh,Kiyohito Yagi,Tadanori Mayumi,Shin-ichi Tsunoda,Yasuo Tsutsumi, NANOTECHNOLOGY, IOP PUBLISHING LTD, Vol. 23, No. 4, 2012/02
  • Safety design of nanoparticle based-vaccine using protein corona, UDAKA Asako,YOSHIOKA Yasuo,YOSHIDA Tokuyuki,UJI Miyuki,MISATO Kazuki,MORI Takahide,HIRAI Toshiro,NAGANO Kazuya,ABE Yasuhiro,KAMADA Haruhiko,TSUNODA Shin-ichi,NABESHI Hiromi,YOSHIKAWA Tomoaki,TSUTSUMI Yasuo, Annual Meeting of the Japanese Society of Toxicology, The Japanese Society of Toxicology, Vol. 39, p. O-39, 2012
  • Safety evaluation of food nanomaterials based on intestinal flora variation, MORI Takahide,YOSHIOKA Yasuo,YOSHIDA Tokuyuki,UJI Miyuki,MISATO Kazuki,UDAKA Asako,HIRAI Toshiro,TSUNODA Shin-ichi,NABESHI Hiromi,YOSHIKAWA Tomoaki,TSUTSUMI Yasuo, Annual Meeting of the Japanese Society of Toxicology, The Japanese Society of Toxicology, Vol. 39, p. O-37, 2012
  • Analysis of amorphous nanosilica particles-mediated blood coagulation, YOSHIDA Tokuyuki,YOSHIOKA Yasuo,TOCHIGI Saeko,UJI Miyuki,MISATO Kazuki,UDAKA Asako,MORI Takahide,HIRAI Toshiro,TSUNODA Shin-ichi,NABESHI Hiromi,YOSHIKAWA Tomoaki,TSUTSUMI Yasuo, Annual Meeting of the Japanese Society of Toxicology, The Japanese Society of Toxicology, Vol. 39, p. O-30, 2012
  • The basic safety assessment of fullerenol by oral administration for the development of safe nanomedicine, YAMASHITA Kohei,YOSHIOKA Yasuo,PAN Huiyan,OGURA Toshinobu,TAIRA Mayu,AOYAMA Michihiko,TSUNODA Shin-ichi,NAKAYAMA Hiroyuki,FUJIO Shigeru,AOSHIMA Hisae,KOKUBO Ken,OSHIMA Takumi,NABESHI Hiromi,YOSHIKAWA Tomoaki,TSUTSUMI Yasuo, Annual Meeting of the Japanese Society of Toxicology, The Japanese Society of Toxicology, Vol. 39, p. O-36, 2012
  • Association between neutrophilia and inflammatory responses for ensuring safety of nanomaterials, HIGASHISAKA Kazuma,YOSHIOKA Yasuo,NAGANO Takashi,KUNIEDA Akiyoshi,HATA Katsutomo,TSUNODA Shin-ichi,NABESHI Hiromi,YOSHIKAWA Tomoaki,TSUTSUMI Yasuo, Annual Meeting of the Japanese Society of Toxicology, The Japanese Society of Toxicology, Vol. 39, p. O-23, 2012
  • Assessment of the microRNA-122 as a biomarker toward the developing of safety nanomaterials, NAGANO Takashi,YOSHIOKA Yasuo,HIGASHISAKA Kazuma,KUNIEDA Akiyoshi,HATA Katsutomo,TSUNODA Shin-ichi,NABESHI Hiromi,YOSHIKAWA Tomoaki,TSUTSUMI Yasuo, Annual Meeting of the Japanese Society of Toxicology, The Japanese Society of Toxicology, Vol. 39, p. O-38, 2012
  • Hazard identification of nano and sub-nano silver following nasal exposure, ICHIHASHI Ko-ichi,YOSHIOKA Yasuo,HIRAI Toshiro,TAKAHASHI Hideki,YOSHIDA Tokuyuki,TSUNODA Shin-ichi,NABESHI Hiromi,YOSHIKAWA Tomoaki,TSUTSUMI Yasuo, Annual Meeting of the Japanese Society of Toxicology, The Japanese Society of Toxicology, Vol. 39, p. O-26, 2012
  • Safety evaluation of sublingually administered nanomaterials and sub-nanomaterials, MISATO Kazuki,YOSHIOKA Yasuo,YOSHIDA Tokuyuki,UJI Miyuki,UDAKA Asako,MORI Takahide,HIRAI Toshiro,AKASE Takanori,TSUNODA Shin-ichi,NABESHI Hiromi,YOSHIKAWA Tomoaki,TSUTSUMI Yasuo, Annual Meeting of the Japanese Society of Toxicology, The Japanese Society of Toxicology, Vol. 39, p. O-27, 2012
  • Sub-nano materials might cause pregnancy complications in mice, SATO Hiroyoshi,YOSHIOKA Yasuo,MORISHITA Yuki,NOJIRI Nao,TSUNODA Shin-ichi,NABESHI Hiromi,YOSHIKAWA Tomoaki,TSUTSUMI Yasuo, Annual Meeting of the Japanese Society of Toxicology, The Japanese Society of Toxicology, Vol. 39, p. O-28, 2012
  • Dermal toxicity of subnano/nano-titanium in rats, KUWAGATA Makiko,MATSUMOTO Aki,KUMAGAI Fumiaki,SAITO Yoshiaki,MARUMO Hideki,NOGUCHI Satoshi,USUMI Kenji,CHISAKA Akiko,FURUYA Mami,SEKI Takayuki,KATOH Hiroyasu,TAKASHIMA Hiromasa,YOSHIDA Tokuyuki,YOSHIKAWA Tomoaki,YOSHIOKA Yasuo,TSUTSUMI Yasuo, Annual Meeting of the Japanese Society of Toxicology, The Japanese Society of Toxicology, Vol. 39, p. P-140, 2012
  • Hazard identification of exposure to nanomaterial in lactation period, YOSHIOKA Yasuo,NOJIRI Nao,MORISHITA Yuki,SATOH Hiroyoshi,TSUNODA Shin-ichi,NABESHI Hiromi,YOSHIKAWA Tomoaki,TSUTSUMI Yasuo, Annual Meeting of the Japanese Society of Toxicology, The Japanese Society of Toxicology, Vol. 39, p. P-138, 2012
  • Nanosilica-mediated enhancement of MHC class I-restricted cross-presentation, TAKAHASHI Hideki,YOSHIOKA Yasuo,HIRAI Toshiro,ICHIHASHI Ko-ichi,YOSHIDA Tokuyuki,TSUNODA Shin-ichi,NABESHI Hiromi,YOSHIKAWA Tomoaki,TSUTSUMI Yasuo, Annual Meeting of the Japanese Society of Toxicology, The Japanese Society of Toxicology, Vol. 39, p. P-137, 2012
  • The hazard identification of amorphous nanosilica particles following dermal applications using the atopic dermatitis model mouse, HIRAI Toshiro,YOSHIOKA Yasuo,ICHIHASHI Ko-ichi,TAKAHASHI Hideki,YOSHIDA Tokuyuki,TAKAGI Tatsuya,TSUNODA Shin-ichi,NABESHI Hiromi,YOSHIKAWA Tomoaki,TSUTSUMI Yasuo, Annual Meeting of the Japanese Society of Toxicology, The Japanese Society of Toxicology, Vol. 39, p. P-136, 2012
  • Intestinal absorption of amorphous nanosilica particles, UJI Miyuki,YOSHIOKA Yasuo,YOSHIDA Tokuyuki,MISATO Kazuki,UDAKA Asako,MORI Takahide,HIRAI Toshiro,TSUNODA Shin-ichi,NABESHI Hiromi,YOSHIKAWA Tomoaki,TSUTSUMI Yasuo, Annual Meeting of the Japanese Society of Toxicology, The Japanese Society of Toxicology, Vol. 39, p. P-134, 2012
  • Identification of new biomarkers for lung cancer by exploring proteins derived from exosomes, Kamada Haruhiko,Yamashita Takuya,Nagano Kazuya,Maeda Yuka,Abe Yasuhiro,Yoshikawa Tomoaki,Yoshioka Yasuo,Tsutsumi Yasuo,Tsunoda Shin-ichi, Abstracts for Annual Meeting of Japanese Proteomics Society, Japanese Proteomics Society (Japan Human Proteome Organisation), Vol. 2012, p. 145-145, 2012
  • ナノカーボンDDSの可能性と安全性, 平井敏郎,吉岡靖雄,堤 康央, 『ドラッグデリバリーシステムの新展開? -核酸医薬・抗体医薬・ワクチン医療を支えるDDS技術-』, 2011/12
  • Induction of Endoplasmic Reticulum-Endosome Fusion for Antigen Cross-Presentation Induced by Poly (gamma-Glutamic Acid) Nanoparticles, Yohei Mukai,Tomoyo Yoshinaga,Mai Yoshikawa,Kazuhiko Matsuo,Tomoaki Yoshikawa,Keisuke Matsuo,Kazuyuki Niki,Yasuo Yoshioka,Naoki Okada,Shinsaku Nakagawa, JOURNAL OF IMMUNOLOGY, AMER ASSOC IMMUNOLOGISTS, Vol. 187, No. 12, p. 6249-6255, 2011/12
  • Lysine-deficient lymphotoxin-alpha mutant for site-specific PEGylation, Shogo Narimatsu,Yasuo Yoshioka,Hikaru Watanabe,Takashi Masano,Tomohiro Morishige,Xinglei Yao,Aya Tanabe,Shin-ichi Tsunoda,Yasuo Tsutsumi,Yohei Mukai,Naoki Okada,Shinsaku Nakagawa, CYTOKINE, ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, Vol. 56, No. 2, p. 489-493, 2011/11
  • Biological and structural characterization of human TNFR2-selective TNF mutants, Yasuhiro Abe,Masaki Inoue,Takeshi Furuya,Yohei Mukai,Teruya Nakamura,Yuriko Yamagata,Hiromi Nabeshi,Tomoaki Yoshikawa,Yasuo Yoshioka,Kazuya Nagano,Haruhiko Kamada,Yasuo Tsutsumi,Shin-ichi Tsunoda, CYTOKINE, ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, Vol. 56, No. 1, p. 78-78, 2011/10
  • Creation of mouse TNFR2-selective TNF mutant using phage display system, Takeshi Furuya,Yasuhiro Abe,Masaki Inoue,Hiromi Nabeshi,Tomoaki Yoshikawa,Yasuo Yoshioka,Norio Itoh,Kazuya Nagano,Haruhiko Kamada,Yasuo Tsutsumi,Shin-ichi Tsunoda, CYTOKINE, ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, Vol. 56, No. 1, p. 90-90, 2011/10
  • Structure-activity relationship of T-cell receptors based on alanine scanning., Narimatsu S,Yoshioka Y,Morishige T,Yao X,Tsunoda S,Tsutsumi Y,Nishimura MI,Mukai Y,Okada N,Nakagawa S, Biochem. Biophys. Res. Commun, 2011/10
  • Detection of titanium dioxide particles on frozen tissue sections using synchrotron radiation X-ray fluorescence analysis, Y. Morishita,K. Yamashita,T. Yoshikawa,Y. Terada,H. Nabeshi,Y. Yoshioka,N. Itoh,Y. Tsutsumi, PHARMAZIE, GOVI-VERLAG PHARMAZEUTISCHER VERLAG GMBH, Vol. 66, No. 10, p. 808-809, 2011/10
  • Tumor Vascular Targeted Delivery of Polymer-conjugated Adenovirus Vector for Cancer Gene Therapy, Xinglei Yao,Yasuo Yoshioka,Tomohiro Morishige,Yusuke Eto,Shogo Narimatsu,Yasuaki Kawai,Hiroyuki Mizuguchi,Jian-Qing Gao,Yohei Mukai,Naoki Okada,Shinsaku Nakagawa, MOLECULAR THERAPY, NATURE PUBLISHING GROUP, Vol. 19, No. 9, p. 1619-1625, 2011/09
  • Size-dependent immune-modulating effect of amorphous nanosilica particles, T. Hirai,T. Yoshikawa,H. Nabeshi,T. Yoshida,S. Tochigi,M. Uji,K. Ichihashi,T. Akase,T. Yamashita,K. Yamashita,K. Nagano,Y. Abe,H. Kamada,S. Tsunoda,Y. Yoshioka,N. Itoh,Y. Tsutsumi, PHARMAZIE, GOVI-VERLAG PHARMAZEUTISCHER VERLAG GMBH, Vol. 66, No. 9, p. 727-728, 2011/09
  • Fine tuning of receptor-selectivity for tumor necrosis factor-alpha using a phage display system with one-step competitive panning, Yasuhiro Abe,Tomoaki Yoshikawa,Masaki Inoue,Tetsuya Nomura,Takeshi Furuya,Takuya Yamashita,Kazuya Nagano,Hiromi Nabeshi,Yasuo Yoshioka,Yohei Mukai,Shinsaku Nakagawa,Haruhiko Kamada,Yasuo Tsutsumi,Shin-ichi Tsunoda, BIOMATERIALS, ELSEVIER SCI LTD, Vol. 32, No. 23, p. 5498-5504, 2011/08
  • Effect of amorphous silica nanoparticles on in vitro RANKL-induced osteoclast differentiation in murine macrophages, Hiromi Nabeshi,Tomoaki Yoshikawa,Takanori Akase,Tokuyuki Yoshida,Saeko Tochigi,Toshiro Hirai,Miyuki Uji,Ko-ichi Ichihashi,Takuya Yamashita,Kazuma Higashisaka,Yuki Morishita,Kazuya Nagano,Yasuhiro Abe,Haruhiko Kamada,Shin-ichi Tsunoda,Norio Itoh,Yasuo Yoshioka,Yasuo Tsutsumi, NANOSCALE RESEARCH LETTERS, SPRINGER, Vol. 6, 2011/07
  • Modifying the antigen-immunization schedule improves the variety of monoclonal antibodies obtained from immune-phage antibody libraries against HIV-1 Nef and Vif, Mai Yoshikawa,Yohei Mukai,Shin-Ichi Tsunoda,Yasuo Tsutsumi,Yasuo Yoshioka,Naoki Okada,Shinsaku Nakagawa, Journal of Bioscience and Bioengineering, Vol. 111, No. 5, p. 597-599, 2011/05
  • Amorphous nanosilica induce endocytosis-dependent ROS generation and DNA damage in human keratinocytes., Nabeshi H,Yoshikawa T,Matsuyama K,Nakazato Y,Tochigi S,Kondoh S,Hirai T,Akase T,Yamashita T,Yamashita K,Yoshida T,Nagano K,Abe Y,Yoshioka Y,Kamada H,Imazawa T,Itoh N,Tsunoda S,Tsutsumi Y, Part. Fibre. Toxicol., 2011/03
  • Limited expression of reticulocalbin-1 in lymphatic endothelial cells in lung tumor but not in normal lung, Yasunobu Yoshida,Takuya Yamashita,Kazuya Nagano,Sunao Imai,Hiromi Nabeshi,Tomoaki Yoshikawa,Yasuo Yoshioka,Yasuhiro Abe,Haruhiko Kamada,Yasuo Tsutsumi,Shin-ichi Tsunoda, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC ELSEVIER SCIENCE, Vol. 405, No. 4, p. 610-614, 2011/02
  • Anti-inflammatory Effects of a Novel TNFR1-Selective Antagonistic TNF Mutant on Established Murine Collagen-Induced Arthritis, Yasuhiro Abe,Tetsuya Nomura,Yasuo Yoshioka,Haruhiko Kamada,Shin-ichi Tsunoda,Yasuo Tsutsumi, ADVANCES IN TNF FAMILY RESEARCH, SPRINGER-VERLAG BERLIN, Vol. 691, p. 493-500, 2011
  • CREATION OF MUTANT LYMPHOTOXIN-ALPHAS WITH ENHANCED BIOACTIVITIES BY PHAGE DISPLAY TECHNIQUE, Yasuo Yoshioka,Hikaru Watanabe,Yasuo Tsutsumi,Yohei Mukai,Naoki Okada,Shinsaku Nakagawa, ADVANCES IN TNF FAMILY RESEARCH, SPRINGER-VERLAG BERLIN, Vol. 691, p. 720-720, 2011
  • RECEPTOR INTERACTION OF TUMOR NECROSIS FACTOR (TNF) BASED ON 3D STRUCTURAL ANALYSIS OF A FULLY ACTIVE TNFR1-SELECTIVE TNF MUTANT, Yohei Mukai,Teruya Nakamura,Yasuo Yoshioka,Yasuhiro Abe,Tetsuya Nomura,Madoka Taniai,Tsunetaka Ohta,Shinji Ikemizu,Shinsaku Nakagawa,Shin-ichi Tsunoda,Haruhiko Kamada,Yuriko Yamagata,Yasuo Tsutsumi, ADVANCES IN TNF FAMILY RESEARCH, SPRINGER-VERLAG BERLIN, Vol. 691, p. 804-804, 2011
  • THE DEVELOPMENT OF FULLY ACTIVE RECEPTOR-SELECTIVE TUMOR NECROSIS FACTOR (TNF) MUTANTS, Mai Yoshikawa,Yohei Mukai,Hiroko Shibata,Yasuo Yoshioka,Yasuhiro Abe,Tetsuya Nomura,Madoka Taniai,Tsunetaka Ohta,Shin-ichi Tsunoda,Haruhiko Kamada,Shinsaku Nakagawa,Yasuo Tsutsumi, ADVANCES IN TNF FAMILY RESEARCH, SPRINGER-VERLAG BERLIN, Vol. 691, p. 805-805, 2011
  • Silica and titanium dioxide nanoparticles cause pregnancy complications in mice, Kohei Yamashita,Yasuo Yoshioka,Kazuma Higashisaka,Kazuya Mimura,Yuki Morishita,Masatoshi Nozaki,Tokuyuki Yoshida,Toshinobu Ogura,Hiromi Nabeshi,Kazuya Nagano,Yasuhiro Abe,Haruhiko Kamada,Youko Monobe,Takayoshi Imazawa,Hisae Aoshima,Kiyoshi Shishido,Yuichi Kawai,Tadanori Mayumi,Shin-Ichi Tsunoda,Norio Itoh,Tomoaki Yoshikawa,Itaru Yanagihara,Shigeru Saito,Yasuo Tsutsumi, Nature Nanotechnology, Nature Publishing Group, Vol. 6, No. 5, p. 321-328, 2011
  • Promotion of allergic immune responses by intranasally-administrated nanosilica particles in mice, Tokuyuki Yoshida,Yasuo Yoshioka,Maho Fujimura,Kohei Yamashita,Kazuma Higashisaka,Yuki Morishita,Hiroyuki Kayamuro,Hiromi Nabeshi,Kazuya Nagano,Yasuhiro Abe,Haruhiko Kamada,Shin-ichi Tsunoda,Norio Itoh,Tomoaki Yoshikawa,Yasuo Tsutsumi, NANOSCALE RESEARCH LETTERS, SPRINGER, Vol. 6, 2011
  • Effect of surface properties of silica nanoparticles on their cytotoxicity and cellular distribution in murine macrophages, Hiromi Nabeshi,Tomoaki Yoshikawa,Akihiro Arimori,Tokuyuki Yoshida,Saeko Tochigi,Toshiro Hirai,Takanori Akase,Kazuya Nagano,Yasuhiro Abe,Haruhiko Kamada,Shin-ichi Tsunoda,Norio Itoh,Yasuo Yoshioka,Yasuo Tsutsumi, NANOSCALE RESEARCH LETTERS, SPRINGER, Vol. 6, 2011
  • Development of an antibody proteomics system using a phage antibody library for efficient screening of biomarker proteins, Sunao Imai,Kazuya Nagano,Yasunobu Yoshida,Takayuki Okamura,Takuya Yamashita,Yasuhiro Abe,Tomoaki Yoshikawa,Yasuo Yoshioka,Haruhiko Kamada,Yohei Mukai,Shinsaku Nakagawa,Yasuo Tsutsumi,Shin-ichi Tsunoda, BIOMATERIALS, ELSEVIER SCI LTD, Vol. 32, No. 1, p. 162-169, 2011/01
  • Systemic distribution, nuclear entry and cytotoxicity of amorphous nanosilica following topical application., Nabeshi H,Yoshikawa T,Matsuyama K,Nakazato Y,Matsuo K,Arimori A,Isobe M,Tochigi S,Kondoh S,Hirai T,Akase T,Yamashita T,Yamashita K,Yoshida T,Nagano K,Abe Y,Yoshioka Y,Kamada H,Imazawa T,Nakagawa S,Mayumi T,Itoh N,Tsunoda S,Tsutsumi Y, Biomaterials, 2011/01
  • Acute phase proteins as biomarkers for predicting the exposure and toxicity of nanomaterials, Kazuma Higashisaka,Yasuo Yoshioka,Kohei Yamashita,Yuki Morishita,Maho Fujimura,Hiromi Nabeshi,Kazuya Nagano,Yasuhiro Abe,Haruhiko Kamada,Shin-ichi Tsunoda,Tomoaki Yoshikawa,Norio Itoh,Yasuo Tsutsumi, BIOMATERIALS, ELSEVIER SCI LTD, Vol. 32, No. 1, p. 3-9, 2011/01
  • Therapeutic effect of PEGylated TNFR1-selective antagonistic mutant TNF in experimental autoimmune encephalomyelitis mice, Tetsuya Nomura,Yasuhiro Abe,Haruhiko Kamada,Hiroko Shibata,Hiroyuki Kayamuro,Masaki Inoue,Tomoyuki Kawara,Shuhei Arita,Takeshi Furuya,Takuya Yamashita,Kazuya Nagano,Tomoaki Yoshikawa,Yasuo Yoshioka,Yohei Mukai,Shinsaku Nakagawa,Madoka Taniai,Tsunetaka Ohta,Satoshi Serada,Tetsuji Naka,Shin-ichi Tsunoda,Yasuo Tsutsumi, JOURNAL OF CONTROLLED RELEASE, ELSEVIER, Vol. 149, No. 1, p. 8-14, 2011/01
  • Transcutaneous vaccination using a hydrogel patch induces effective immune responses to tetanus and diphtheria toxoid in hairless rat, Kazuhiko Matsuo,Yumiko Ishii,Ying-Shu Quan,Fumio Kamiyama,Yohei Mukai,Yasuo Yoshioka,Naoki Okada,Shinsaku Nakagawa, JOURNAL OF CONTROLLED RELEASE, ELSEVIER SCIENCE BV, Vol. 149, No. 1, p. 15-20, 2011/01
  • The Utility of Poly(gamma-glutamic acid) Nanoparticles as Antigen Delivery Carriers in Dendritic Cell-Based Cancer Immunotherapy, Keisuke Matsuo,Yumiko Ishii,Kazuhiko Matsuo,Tomoyo Yoshinaga,Mitsuru Akashi,Yohei Mukai,Yasuo Yoshioka,Naoki Okada,Shinsaku Nakagawa, BIOLOGICAL & PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOC JAPAN, Vol. 33, No. 12, p. 2003-2007, 2010/12
  • Interleukin-1 Family Cytokines as Mucosal Vaccine Adjuvants for Induction of Protective Immunity against Influenza Virus, Hiroyuki Kayamuro,Yasuo Yoshioka,Yasuhiro Abe,Shuhei Arita,Kazufumi Katayama,Tetsuya Nomura,Tomoaki Yoshikawa,Ritsuko Kubota-Koketsu,Kazuyoshi Ikuta,Shigefumi Okamoto,Yasuko Mori,Jun Kunisawa,Hiroshi Kiyono,Norio Itoh,Kazuya Nagano,Haruhiko Kamada,Yasuo Tsutsumi,Shin-Ichi Tsunoda, JOURNAL OF VIROLOGY, AMER SOC MICROBIOLOGY, Vol. 84, No. 24, p. 12703-12712, 2010/12
  • Potential adjuvant effect of intranasal urban aerosols in mice through induction of dendritic cell maturation, Tokuyuki Yoshida,Yasuo Yoshioka,Maho Fujimura,Kohei Yamashita,Kazuma Higashisaka,Ryosuke Nakanishi,Yuki Morishita,Hiroyuki Kayamuro,Hiromi Nabeshi,Kazuya Nagano,Yasuhiro Abe,Haruhiko Kamada,Shinichi Tsunoda,Tomoaki Yoshikawa,Norio Itoh,Yasuo Tsutsumi, TOXICOLOGY LETTERS, ELSEVIER IRELAND LTD, Vol. 199, No. 3, p. 383-388, 2010/12
  • Anti-inflammatory effects of a novel TNFR1-selective antagonistic TNF mutant in murine experimental autoimmune encephalomyelitis, Yasuhiro Abe,Tetsuya Nomura,Masaki Inoue,Shu-hei Arita,Takeshi Furuya,Tomoaki Yoshikawa,Yasuo Yoshioka,Kazuya Nagano,Haruhiko Kamada,Yasuo Tsutsumi,Shin-ichi Tsunoda, CYTOKINE, ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, Vol. 52, No. 1-2, p. 45-45, 2010/10
  • The potential use of IL-1 family cytokines as mucosal adjuvants for a NASA influenza vaccine, Shu-hei Arita,Hiroyuki Kayamuro,Yasuhiro Abe,Yasuo Yoshioka,Haruhiko Kamada,Tsuyoshi Furuya,Norio Itoh,Tomoaki Yoshikawa,Kazuya Nagano,Yasuo Tsutsumi,Shin-ichi Tsunoda, CYTOKINE, ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, Vol. 52, No. 1-2, p. 89-90, 2010/10
  • Optimized PEGylated Adenovirus Vector Reduces the Anti-vector Humoral Immune Response against Adenovirus and Induces a Therapeutic Effect against Metastatic Lung Cancer, Yusuke Eto,Yasuo Yoshioka,Tatsuhiro Ishida,Xinglei Yao,Tomohiro Morishige,Shogo Narimatsu,Hiroyuki Mizuguchi,Yohei Mukai,Naoki Okada,Hiroshi Kiwada,Shinsaku Nakagawa, BIOLOGICAL & PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOC JAPAN, Vol. 33, No. 9, p. 1540-1544, 2010/09
  • The effect of surface modification of amorphous silica particles on NLRP3 inflammasome mediated IL-1 beta production, ROS production and endosomal rupture, Tomohiro Morishige,Yasuo Yoshioka,Hiroshi Inakura,Aya Tanabe,Xinglei Yao,Shogo Narimatsu,Youko Monobe,Takayoshi Imazawa,Shin-ichi Tsunoda,Yasuo Tsutsumi,Yohei Mukai,Naoki Okada,Shinsaku Nakagawa, BIOMATERIALS, ELSEVIER SCI LTD, Vol. 31, No. 26, p. 6833-6842, 2010/09
  • Cytotoxicity of amorphous silica particles against macrophage-like THP-1 cells depends on particle-size and surface properties, T. Morishige,Y. Yoshioka,H. Inakura,A. Tanabe,X. Yao,S. Tsunoda,Y. Tsutsumi,Y. Mukai,N. Okada,S. Nakagawa, PHARMAZIE, GOVI-VERLAG PHARMAZEUTISCHER VERLAG GMBH, Vol. 65, No. 8, p. 596-599, 2010/08
  • Carbon Nanotubes Elicit DNA Damage and Inflammatory Response Relative to Their Size and Shape, Kohei Yamashita,Yasuo Yoshioka,Kazuma Higashisaka,Yuki Morishita,Tokuyuki Yoshida,Maho Fujimura,Hiroyuki Kayamuro,Hiromi Nabeshi,Takuya Yamashita,Kazuya Nagano,Yasuhiro Abe,Haruhiko Kamada,Yuichi Kawai,Tadanori Mayumi,Tomoaki Yoshikawa,Norio Itoh,Shin-ichi Tsunoda,Yasuo Tsutsumi, INFLAMMATION, SPRINGER/PLENUM PUBLISHERS, Vol. 33, No. 4, p. 276-280, 2010/08
  • Adenovirus Vector Covalently Conjugated to Polyethylene Glycol with a Cancer-Specific Promoter Suppresses the Tumor Growth through Systemic Administration, Xinglei Yao,Yasuo Yoshioka,Tomohiro Morishige,Yusuke Eto,Shogo Narimatsu,Hiroyuki Mizugguchi,Yohei Mukai,Naoki Okada,Shinsaku Nakagawa, BIOLOGICAL & PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOC JAPAN, Vol. 33, No. 6, p. 1073-1076, 2010/06
  • Simple PEG Conjugation of SPIO via an Au-S Bond Improves Its Tumor Targeting Potency as a Novel MR Tumor Imaging Agent, Hiroki Kojima,Yohei Mukai,Mai Yoshikawa,Kazumasa Kamei,Tomoaki Yoshikawa,Masahito Morita,Toshiro Inubushi,Takao A. Yamamoto,Yasuo Yoshioka,Naoki Okada,Satoshi Seino,Shinsaku Nakagawa, BIOCONJUGATE CHEMISTRY, AMER CHEMICAL SOC, Vol. 21, No. 6, p. 1026-1031, 2010/06
  • Urban Aerosols Induce Pro-inflammatory Cytokine Production in Macrophages and Cause Airway Inflammation in Vivo, Tokuyuki Yoshida,Yasuo Yoshioka,Maho Fujimura,Hiroyuki Kayamuro,Kohei Yamashita,Kazuma Higashisaka,Ryosuke Nakanishi,Yuki Morishita,Hiromi Nabeshi,Takuya Yamashita,Masashi Muroi,Kenichi Tanamoto,Kazuya Nagano,Yasuhiro Abe,Haruhiko Kamada,Yuichi Kawai,Tadanori Mayumi,Norio Itoh,Tomoaki Yoshikawa,Shinichi Tsunoda,Yasuo Tsutsumi, BIOLOGICAL & PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOC JAPAN, Vol. 33, No. 5, p. 780-783, 2010/05
  • Creation of a LIGHT mutant with the capacity to evade the decoy receptor for cancer therapy, Tomohiro Morishige,Yasuo Yoshioka,Hiroshi Inakura,Aya Tanabe,Xinglei Yao,Shin-ichi Tsunoda,Yasuo Tsutsumi,Yohei Mukai,Naoki Okada,Shinsaku Nakagawa, BIOMATERIALS, ELSEVIER SCI LTD, Vol. 31, No. 12, p. 3357-3363, 2010/04
  • Mutant TNF-alpha, mTNF-K90R, is a novel candidate adjuvant for a mucosal vaccine against HIV, H. Kayamuro,Y. Abe,Y. Yoshioka,K. Katayama,T. Yoshida,K. Yamashita,T. Yoshikawa,Y. Kawai,T. Mayumi,T. Hiroi,N. Itoh,K. Nagano,H. Kamada,S. Tsunoda,Y. Tsutsumi, PHARMAZIE, GOVI-VERLAG PHARMAZEUTISCHER VERLAG GMBH, Vol. 65, No. 4, p. 254-256, 2010/04
  • Generation of mouse macrophages expressing membrane-bound TNF variants with selectivity for TNFR1 or TNFR2, Hiroko Shibata,Yasuhiro Abe,Yasuo Yoshioka,Tetsuya Nomura,Masaki Sato,Hiroyuki Kayamuro,Tomoyuki Kawara,Shuhei Arita,Tsuyoshi Furuya,Kazuya Nagano,Tomoaki Yoshikawa,Haruhiko Kamada,Shin-ichi Tsunoda,Yasuo Tsutsumi, CYTOKINE, ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, Vol. 50, No. 1, p. 75-83, 2010/04
  • Creation of a LIGHT mutant with the capacity to evade the decoy receptor for cancer therapy, Tomohiro Morishige,Yasuo Yoshioka,Hiroshi Inakura,Aya Tanabe,Xinglei Yao,Shin-ichi Tsunoda,Yasuo Tsutsumi,Yohei Mukai,Naoki Okada,Shinsaku Nakagawa, BIOMATERIALS, ELSEVIER SCI LTD, Vol. 31, No. 12, p. 3357-3363, 2010/04
  • 「貼るワクチン」の開発 生分解性マイクロニードルを用いたマラリアワクチンの開発, 綾部 有里香,松尾 一彦,権 英淑,神山 文男,堀井 俊宏,向 洋平,吉岡 靖雄,岡田 直貴,中川 晋作, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 130年会, No. 4, p. 163-163, 2010/03
  • Size-dependent cytotoxic effects of amorphous silica nanoparticles on Langerhans cells, H. Nabeshi,T. Yoshikawa,K. Matsuyama,Y. Nakazato,A. Arimori,M. Isobe,S. Tochigi,S. Kondoh,T. Hirai,T. Akase,T. Yamashita,K. Yamashita,T. Yoshida,K. Nagano,Y. Abe,Y. Yoshioka,H. Kamada,T. Imazawa,N. Itoh,S. Tsunoda,Y. Tsutsumi, PHARMAZIE, GOVI-VERLAG PHARMAZEUTISCHER VERLAG GMBH, Vol. 65, No. 3, p. 199-201, 2010/03
  • Tumor-targeting CTL expressing a single-chain FV specific for VEGFR2, Naoko Kanagawa,Tatsuya Yanagawa,Yohei Mukai,Yasuo Yoshioka,Naoki Okada,Shinsaku Nakagawa, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC ELSEVIER SCIENCE, Vol. 394, No. 1, p. 54-58, 2010/03
  • Creation of a lysine-deficient LIGHT mutant with the capacity for site-specific PEGylation and low affinity for a decoy receptor, Tomohiro Morishige,Yasuo Yoshioka,Hiroshi Inakura,Aya Tanabe,Xinglei Yao,Shin-ichi Tsunoda,Yasuo Tsutsumi,Yohei Mukai,Naoki Okada,Shinsaku Nakagawa, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC ELSEVIER SCIENCE, Vol. 393, No. 4, p. 888-893, 2010/03
  • Creation of lysine-deficient mutant lymphotoxin-alpha with receptor selectivity by using a phage display system, Yasuo Yoshioka,Hikaru Watanabe,Tomohiro Morishige,Xinglei Yao,Shinji Ikemizu,Chioko Nagao,Shandar Ahmad,Kenji Mizuguchi,Shin-ichi Tsunoda,Yasuo Tsutsumi,Yohei Mukai,Naoki Okada,Shinsaku Nakagawa, BIOMATERIALS, ELSEVIER SCI LTD, Vol. 31, No. 7, p. 1935-1943, 2010/03
  • Creation of an improved mutant TNF with TNFR1-selectivity and antagonistic activity by phage display technology, T. Nomura,Y. Abe,H. Kamada,M. Inoue,T. Kawara,S. Arita,T. Furuya,K. Minowa,Y. Yoshioka,H. Shibata,H. Kayamuro,T. Yamashita,K. Nagano,T. Yoshikawa,Y. Mukai,S. Nakagawa,S. Tsunoda,Y. Tsutsumi, PHARMAZIE, GOVI-VERLAG PHARMAZEUTISCHER VERLAG GMBH, Vol. 65, No. 2, p. 93-96, 2010/02
  • Titanium dioxide induces different levels of IL-1 beta production dependent on its particle characteristics through caspase-1 activation mediated by reactive oxygen species and cathepsin B, Tomohiro Morishige,Yasuo Yoshioka,Aya Tanabe,Xinglei Yao,Shin-ichi Tsunoda,Yasuo Tsutsumi,Yohei Mukai,Naoki Okada,Shinsaku Nakagawa, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC ELSEVIER SCIENCE, Vol. 392, No. 2, p. 160-165, 2010/02
  • Evaluation of Synthetic Cell-Penetrating Peptides, Pro-Rich Peptide and Octaargine Derivatives, as Adenovirus Vector Carrier, Shinya Kida,Yusuke Eto,Yasuo Yoshioka,Shinsaku Nakagawa,Koichi Kawasaki,Mitsuko Maeda, PROTEIN AND PEPTIDE LETTERS, BENTHAM SCIENCE PUBL LTD, Vol. 17, No. 2, p. 164-167, 2010
  • Structure of the TNF-TNFR2 complex, Mukai Y,Nakamura T,Yoshikawa M,Yoshioka Y,Tsunoda S,Nakagawa S,Yamagata Y,Tsutsumi Y, Sci Signal., AMER ASSOC ADVANCEMENT SCIENCE, Vol. 2010 Nov 16;3(148), No. 148, 2010
  • Comparison of the anti-tumor activity of native, secreted, and membrane-bound LIGHT in mouse tumor models, Tomohiro Morishige,Yasuo Yoshioka,Aya Tanabe,Xinglei Yao,Hiroyuki Mizuguchi,Shin-ichi Tsunoda,Yasuo Tsutsumi,Yohei Mukai,Naoki Okada,Shinsaku Nakagawa, INTERNATIONAL IMMUNOPHARMACOLOGY, ELSEVIER SCIENCE BV, Vol. 10, No. 1, p. 26-33, 2010/01
  • The treatment of established murine collagen-induced arthritis with a TNFR1-selective antagonistic mutant TNF, Hiroko Shibata,Yasuo Yoshioka,Yasuhiro Abe,Akiko Ohkawa,Tetsuya Nomura,Kyoko Minowa,Yohei Mukai,Shinsaku Nakagawa,Madoka Taniai,Tsunetaka Ohta,Haruhiko Kamada,Shin-ichi Tsunoda,Yasuo Tsutsumi, BIOMATERIALS, ELSEVIER SCI LTD, Vol. 30, No. 34, p. 6638-6647, 2009/12
  • Systemic administration of a PEGylated adenovirus vector with a cancer-specific promoter is effective in a mouse model of metastasis, X. Yao,Y. Yoshioka,T. Morishige,Y. Eto,H. Watanabe,Y. Okada,H. Mizuguchi,Y. Mukai,N. Okada,S. Nakagawa, GENE THERAPY, NATURE PUBLISHING GROUP, Vol. 16, No. 12, p. 1395-1404, 2009/12
  • LIGHT protein suppresses tumor growth by augmentation of immune response, Tomohiro Morishige,Yasuo Yoshioka,Hiroshi Inakura,Aya Tanabe,Hikaru Watanabe,Xinglei Yao,Shin-ichi Tsunoda,Yasuo Tsutsumi,Yohei Mukai,Naoki Okada,Shinsaku Nakagawa, IMMUNOLOGY LETTERS, ELSEVIER SCIENCE BV, Vol. 127, No. 1, p. 33-38, 2009/12
  • Creation of lysine-deficient mutant lymphotoxin-alpha with receptor selectivity by using phage display, Yoshioka Yasuo,Watanabe Hikaru,Morishige Tomohiro,Yao Xinglei,Ikemizu Shinji,Nagao Chioko,Ahmad Shandar,Mizuguchi Kenji,Tsutsumi Yasuo,Mukai Yohei,Okada Naoki,Nakagawa Shinsaku, CYTOKINE, Vol. 48, No. 1月2日, 2009/10
  • TNFR1-selectivity improvement of mutant TNF with antagonistic activity, Tetsuya Nomura,Yasuhiro Abe,Masaki Inoue,Yasuo Yoshioka,Hiroyuki Kayamuro,Yohei Mukai,Madoka Taniai,Tsunetaka Ohta,Shinsaku Nakagawa,Haruhiko Kamada,Shin-ichi Tsunoda,Yasuo Tsutsumi, CYTOKINE, ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, Vol. 48, No. 1-2, p. 73-73, 2009/10
  • Characterization of mucosal and systemic immune responses elicited by interleukin cytokines as mucosal adjuvant against influenza virus, Hiroyuki Kayamuro,Yasuo Yoshioka,Yasuhiro Abe,Shu-hei Arita,Kazufumi Katayama,Haruhiko Kamada,Tetsuya Nomura,Norio Itoh,Tomoaki Yoshikawa,Kazuya Nagano,Shin-ich Tsunoda,Yasuo Tsutsumi, CYTOKINE, ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, Vol. 48, No. 1-2, p. 109-109, 2009/10
  • Mast cells are required for interleukin-18 dependent mucosal immune responses, Yasuhiro Abe,Hiroyuki Kayamuro,Yasuo Yoshioka,Shu-hei Arita,Haruhiko Kamada,Tetsuya Nomura,Norio Itoh,Tomoaki Yoshikawa,Kazuya Nagano,Shin-ich Tsunoda,Yasuo Tsutsumi, CYTOKINE, ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, Vol. 48, No. 1-2, p. 111-111, 2009/10
  • The use of a mutant TNF-alpha as a vaccine adjuvant for the induction of mucosal immune responses, Hiroyuki Kayamuro,Yasuhiro Abe,Yasuo Yoshioka,Kazufumi Katayama,Tetsuya Nomura,Tokuyuki Yoshida,Kohei Yamashita,Tomoaki Yoshikawa,Yuichi Kawai,Tadanori Mayumi,Takachika Hiroi,Norio Itoh,Kazuya Nagano,Haruhiko Kamada,Shin-ichi Tsunoda,Yasuo Tsutsumi, BIOMATERIALS, ELSEVIER SCI LTD, Vol. 30, No. 29, p. 5869-5876, 2009/10
  • Novel protein engineering strategy for creating highly receptor-selective mutant TNFs, Tetsuya Nomura,Yasuhiro Abe,Haruhiko Kamada,Masaki Inoue,Tomoyuki Kawara,Shuhei Arita,Takeshi Furuya,Yasuo Yoshioka,Hiroko Shibata,Hiroyuki Kayamuro,Takuya Yamashita,Kazuya Nagano,Tomoaki Yoshikawa,Yohei Mukai,Shinsaku Nakagawa,Madoka Taniai,Tsunetaka Ohta,Shin-ichi Tsunoda,Yasuo Tsutsumi, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC ELSEVIER SCIENCE, Vol. 388, No. 4, p. 667-671, 2009/10
  • Nanosilicas with different sizes and surface charges induce different profiles of cytokine production on macrophages, Yasuo Yoshioka,Tomohiro Morishige,Aya Tanabe,Yasuo Tsutsumi,Yohei Mukai,Naoki Okada,Shinsaku Nakagawa, TOXICOLOGY LETTERS, ELSEVIER IRELAND LTD, Vol. 189, p. S182-S182, 2009/09
  • Fast Binding Kinetics and Conserved 3D Structure Underlie the Antagonistic Activity of Mutant TNF: Useful Information for Designing Artificial Proteo-Antagonists, Yohei Mukai,Teruya Nakamura,Yasuo Yoshioka,Hiroko Shibata,Yasuhiro Abe,Tetsuya Nomura,Madoka Taniai,Tsunetaka Ohta,Shinsaku Nakagawa,Shin-ichi Tsunoda,Haruhiko Kamada,Yuriko Yamagata,Yasuo Tsutsumi, JOURNAL OF BIOCHEMISTRY, OXFORD UNIV PRESS, Vol. 146, No. 2, p. 167-172, 2009/08
  • Transduction of adenovirus vectors modified with cell-penetrating peptides, Yusuke Eto,Yasuo Yoshioka,Ratima Asavatanabodee,Shinya Kida,Mitsuko Maeda,Yohei Mukai,Hiroyuki Mizuguchi,Koichi Kawasaki,Naoki Okada,Shinsaku Nakagawa, PEPTIDES, ELSEVIER SCIENCE INC, Vol. 30, No. 8, p. 1548-1552, 2009/08
  • Arsenic Trioxide Inhibits Human T Cell-Lymphotropic Virus-1-Induced Syncytiums by Down-Regulating gp46, Hiromi Nabeshi,Tomoaki Yoshikawa,Haruhiko Kamada,Hiroko Shibata,Toshiki Sugita,Yasuhiro Abe,Kazuya Nagano,Tetsuya Nomura,Kyoko Minowa,Takuya Yamashita,Norio Itoh,Yasuo Yoshioka,Shin-ichi Tsunoda,Yasuo Tsutsumi, BIOLOGICAL & PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOC JAPAN, Vol. 32, No. 7, p. 1286-1288, 2009/07
  • TNF superfamily member, TL1A, is a potential mucosal vaccine adjuvant, Hiroyuki Kayamuro,Yasuo Yoshioka,Yasuhiro Abe,Kazufumi Katayama,Tokuyuki Yoshida,Kohei Yamashita,Tomoaki Yoshikawa,Takachika Hiroi,Norio Itoh,Yuichi Kawai,Tadanori Mayumi,Haruhiko Kamada,Shin-ichi Tsunoda,Yasuo Tsutsumi, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC ELSEVIER SCIENCE, Vol. 384, No. 3, p. 296-300, 2009/07
  • Molecular cloning, expression, and characterization of a major 38-kd cochineal allergen, Yoko Ohgiya,Fumihiro Arakawa,Hiroshi Akiyama,Yasuo Yoshioka,Yoshiki Hayashi,Shinobu Sakai,Sumio Ito,Yuko Yamakawa,Satoru Ohgiya,Zenro Ikezawa,Reiko Teshima, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, MOSBY-ELSEVIER, Vol. 123, No. 5, p. 1157-1162, 2009/05
  • Direct cell entry of gold/iron-oxide magnetic nanoparticles in adenovirus mediated gene delivery, Kazumasa Kamei,Yohei Mukai,Hiroki Kojima,Tomoaki Yoshikawa,Mai Yoshikawa,George Kiyohara,Takao A. Yamamoto,Yasuo Yoshioka,Naoki Okada,Satoshi Seino,Shinsaku Nakagawa, BIOMATERIALS, ELSEVIER SCI LTD, Vol. 30, No. 9, p. 1809-1814, 2009/03
  • Crystallization and preliminary X-ray analysis of the tumour necrosis factor alpha-tumour necrosis factor receptor type 2 complex, Yohei Mukai,Teruya Nakamura,Yasuo Yoshioka,Shin-ichi Tsunoda,Haruhiko Kamada,Shinsaku Nakagawa,Yuriko Yamagata,Yasuo Tsutsumi, ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, INT UNION CRYSTALLOGRAPHY, Vol. 65, p. 295-298, 2009/03
  • CREATION OF MUTANT LYMPHOTOXIN-ALPHAS WITH ENHANCED BIOACTIVITIES BY PHAGE DISPLAY TECHNIQUE, Yasuo Yoshioka,Hikaru Watanabe,Yasuo Tsutsumi,Yohei Mukai,Naoki Okada,Shinsaku Nakagawa, JOURNAL OF PHYSIOLOGICAL SCIENCES, SPRINGER TOKYO, Vol. 59, p. 157-157, 2009
  • Structure-function relationship of tumor necrosis factor (TNF) and its receptor interaction based on 3D structural analysis of a fully active TNFR1-selective TNF mutant, Mukai Y,Shibata H,Nakamura T,Yoshioka Y,Abe Y,Nomura T,Taniai M,Ohta T,Ikemizu S,Nakagawa S,Tsunoda S,Kamada H,Yamagata Y,Tsutsumi Y, J Mol Biol, 2009/01
  • Orally administered apple procyanidins protect against experimental inflammatory bowel disease in mice, Yasuo Yoshioka,Hiroshi Akiyama,Masataka Nakano,Toshihiko Shoji,Tomomasa Kanda,Yasuyuki Ohtake,Toshichika Takita,Rieko Matsuda,Tamio Maitani, INTERNATIONAL IMMUNOPHARMACOLOGY, ELSEVIER SCIENCE BV, Vol. 8, No. 13-14, p. 1802-1807, 2008/12
  • Tat conjugation of adenovirus vector broadens tropism and enhances transduction efficiency, Yasuo Yoshioka,Ratima Asavatanabodee,Yusuke Eto,Hikaru Watanabe,Tomohiro Morishige,Xinglei Yao,Shinya Kida,Mitsuko Maeda,Yohei Mukai,Hiroyuki Mizuguchi,Koichi Kawasaki,Naoki Okada,Shinsaku Nakagawa, LIFE SCIENCES, PERGAMON-ELSEVIER SCIENCE LTD, Vol. 83, No. 21-22, p. 747-755, 2008/11
  • The therapeutic effect of TNFR1-selective antagonistic mutant TNF-alpha in murine hepatitis models, Hiroko Shibata,Yasuo Yoshioka,Akiko Ohkawa,Yasuhiro Abe,Tetsuya Nomura,Yohei Mukai,Shinsaku Nakagawa,Madoka Taniai,Tsunetaka Ohta,Tadanori Mayumi,Haruhiko Kamada,Shin-ichi Tsunoda,Yasuo Tsutsumi, CYTOKINE, ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, Vol. 44, No. 2, p. 229-233, 2008/11
  • Fine tuning of receptor-selectivity for TNF using a phage display system with one-step competitive-subtractive panning, Yasuhiro Abe,Hiroko Shibata,Tetsuya Nomura,Hiroyuki Kayamuro,Yohei Mukai,Tomoaki Yoshikawa,Yasuo Yoshioka,Madoka Taniai,Tsunetaka Ohta,Shinsaku Nakagawa,Haruhiko Kamada,Shin-ichi Tsunoda,Yasuo Tsutsumi, CYTOKINE, ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD, Vol. 43, No. 3, p. 294-295, 2008/09
  • Creation of mutant TNF with TNF receptor-1 selective antagonistic activity for the development of a novel autoimune disease drug, Tetsuya Nomura,Yasuhiro Abe,Yasuo Yoshioka,Hiroko Shibata,Hiroyuki Kayamuro,Yohei Mukai,Madoka Taniai,Tsunetaka Ohta,Shinsaku Nakagawa,Haruhiko Kamada,Shin-ichi Tsunoda,Yasuo Tsutsumi, CYTOKINE, ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD, Vol. 43, No. 3, p. 259-259, 2008/09
  • Structure-function relationship of TNF based on 3D structural analysis of fully active TNFR1-selective TNF mutant, Yohei Mukai,Hiroko Shibata,Teruya Nakamura,Yasuo Yoshioka,Yasuhiro Abe,Tetsuya Nomura,Madoka Taniai,Tsunetaka Ohta,Shinji Ikemizu,Shinsaku Nakagawa,Shin-ichi Tsunoda,Haruhiko Kamada,Yuriko Yamagata,Yasuo Tsutsumi, CYTOKINE, ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD, Vol. 43, No. 3, p. 295-295, 2008/09
  • Ligand-independent assembly of purified soluble magic roundabout (Robo4), a tumor-specific endothelial marker, Mai Yoshikawa,Yohei Mukai,Yoshiaki Okada,Yasuo Yoshioka,Shin-ichi Tsunoda,Yasuo Tsutsumi,Naoki Okada,William C. Aird,Takefumi Doi,Shinsaku Nakagawa, PROTEIN EXPRESSION AND PURIFICATION, ACADEMIC PRESS INC ELSEVIER SCIENCE, Vol. 61, No. 1, p. 78-82, 2008/09
  • Antitumor mechanism of intratumoral injection with IL-12-expressing adenoviral vector against IL-12-unresponsive tumor, Naoko Kanagawa,Jian-Qing Gao,Yoshiaki Motomura,Tatsuya Yanagawa,Yohei Mukai,Yasuo Yoshioka,Naoki Okada,Shinsaku Nakagawa, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC ELSEVIER SCIENCE, Vol. 372, No. 4, p. 821-825, 2008/08
  • Organelle-targeted delivery of biological macromolecules using the protein transduction domain: Potential applications for peptide aptamer delivery into the nucleus, Tomoaki Yoshikawa,Toshiki Sugita,Yohei Mukai,Natsue Yamanada,Kazuya Nagano,Hiromi Nabeshi,Yasuo Yoshioka,Shinsaku Nakagawa,Yasuhiro Abe,Haruhiko Kamada,Shin-ichi Tsunoda,Yasuo Tsutsumi, JOURNAL OF MOLECULAR BIOLOGY, ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD, Vol. 380, No. 5, p. 777-782, 2008/07
  • Simple and highly sensitive assay system for TNFR2-mediated soluble- and transmembrane-TNF activity, Yasuhiro Abe,Tomoaki Yoshikawa,Haruhiko Kamada,Hiroko Shibata,Tetsuya Nomura,Kyoko Minowa,Hiroyuki Kayamuro,Kazufumi Katayama,Hiroyuki Miyoshi,Yohei Mukai,Yasuo Yoshioka,Shinsaku Nakagawa,Shin-ichi Tsunoda,Yasuo Tsutsumi, JOURNAL OF IMMUNOLOGICAL METHODS, ELSEVIER SCIENCE BV, Vol. 335, No. 1-2, p. 71-78, 2008/06
  • Comparative study on transduction and toxicity of protein transduction domains, T. Sugita,T. Yoshikawa,Y. Mukai,N. Yamanada,S. Imai,K. Nagano,Y. Yoshida,H. Shibata,Y. Yoshioka,S. Nakagawa,H. Kamada,S-i Tsunoda,Y. Tsutsumi, BRITISH JOURNAL OF PHARMACOLOGY, NATURE PUBLISHING GROUP, Vol. 153, No. 6, p. 1143-1152, 2008/03
  • Preparation of a Tat-related transporter peptide for carrying the adenovirus vector into cells, Shinya Kida,Yusuke Eto,Mitsuko Maeda,Yasuo Yoshioka,Shinsaku Nakagawa,Keiko Hojo,Yuko Tsuda,Tadanori Mayumi,Koichi Kawasaki, PROTEIN AND PEPTIDE LETTERS, BENTHAM SCIENCE PUBL LTD, Vol. 15, No. 2, p. 219-222, 2008/02
  • Development of amphiphilic gamma-PGA-nanoparticle based tumor vaccine: Potential of the nanoparticulate cytosolic protein delivery carrier, Tomoaki Yoshikawa,Naoki Okada,Atsushi Oda,Kazuhiko Matsuo,Keisuke Matsuo,Yohei Mukai,Yasuo Yoshioka,Takami Akagi,Mitsuru Akashi,Shinsaku Nakagawa, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC ELSEVIER SCIENCE, Vol. 366, No. 2, p. 408-413, 2008/02
  • 3P-081 Creation of TNFR1-selective mutant lymphotoxin alpha using phage display system(The 46th Annual Meeting of the Biophysical Society of Japan), Watanabe Hikaru,Yoshioka Yasuo,Morishige Tomohiro,Tsunoda Shin-ichi,Tsutsumi Yasuo,Mukai Yohei,Okada Naoki,Nakagawa Shinsaku, Seibutsu Butsuri, The Biophysical Society of Japan General Incorporated Association, Vol. 48, p. S139-S140, 2008
  • Creation and x-ray structure analysis of the tumor necrosis factor receptor-1-selective mutant of a tumor necrosis factor-alpha antagonist, Hiroko Shibata,Yasuo Yoshioka,Akiko Ohkawa,Kyoko Minowa,Yohei Mukai,Yasuhiro Abe,Madoka Taniai,Tetsuya Nomura,Hiroyuki Kayamuro,Hiromi Nabeshi,Toshiki Sugita,Sunao Imai,Kazuya Nagano,Tomoaki Yoshikawa,Takuya Fujita,Shinsaku Nakagawa,Akira Yamamoto,Tsunetaka Ohta,Takao Hayakawa,Tadanori Mayumi,Peter Vandenabeele,Bharat B. Aggarwal,Teruya Nakamura,Yuriko Yamagata,Shin-ichi Tsunoda,Haruhiko Kamada,Yasuo Tsutsumi, JOURNAL OF BIOLOGICAL CHEMISTRY, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, Vol. 283, No. 2, p. 998-1007, 2008/01
  • Efficient generation of antigen-specific cellular immunity by vaccination with poly(γ-glutamic acid) nanoparticles entrapping endoplasmic reticulum-targeted peptides, Keisuke Matsuo,Tomoaki Yoshikawa,Atsushi Oda,Takami Akagi,Mitsuru Akashi,Yohei Mukai,Yasuo Yoshioka,Naoki Okada,Shinsaku Nakagawa, Biochemical and Biophysical Research Communications, Vol. 362, No. 4, p. 1069-1072, 2007/11/03
  • Improved cytosolic translocation and tumor-killing activity of Tat-shepherdin conjugates mediated by co-treatment with Tat-fused endosome-disruptive HA2 peptide, Toshiki Sugita,Tomoaki Yoshikawa,Yohei Muka,Natsue Yamanada,Imai Sunao,Kazuya Nagano,Yasunobu Yoshida,Hiroko Shibata,Yasuo Yoshioka,Shinsaku Nakagawa,Haruhiko Kamada,Shin-Ichi Tsunoda,Yasuo Tsutsumi, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC ELSEVIER SCIENCE, Vol. 363, No. 4, p. 1027-1032, 2007/11
  • TERT promoter-driven adenovirus vector for cancer gene therapy via systemic injection, Xinglei Yao,Yasuo Yoshioka,Yusuke Eto,Tomohiro Morishige,Yuka Okada,Hiroyuki Mizuguchi,Yohei Mukal,Naoki Okada,Shinsaku Nakagawa, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC ELSEVIER SCIENCE, Vol. 362, No. 2, p. 419-424, 2007/10
  • Effective tumor targeted gene transfer using PEGylated adenovirus vector via systemic administration., Jian-Qing Gao,Yusuke Eto,Yasuo Yoshioka,Fumiko Sekiguchi,Shinnosuke Kurachi,Tomohiro Morishige,Xinglei Yao,Hikaru Watanabe,Ratima Asavatanabodee,Fuminori Sakurai,Hiroyuki Mizuguchi,Yuka Okada,Yohei Mukai,Yasuo Tsutsumi,Tadanori Mayumi,Naoki Okada,Shinsaku Nakagawa, Journal of controlled release : official journal of the Controlled Release Society, Vol. 122, No. 1, p. 102-10, 2007/09/11
  • Role of amino acid residue 90 in bioactivity and receptor binding capacity of tumor necrosis factor mutants., Hiroko Shibata,Haruhiko Kamada,Kyoko Kobayashi-Nishibata,Yasuo Yoshioka,Toshihide Nishibata,Yasuhiro Abe,Tetsuya Nomura,Hiromi Nabeshi,Kyoko Minowa,Yohei Mukai,Shinsaku Nakagawa,Tadanori Mayumi,Shin-Ichi Tsunoda,Yasuo Tsutsumi, Biochimica et biophysica acta, Vol. 1774, No. 8, p. 1029-35, 2007/08
  • Role of amino acid residue 90 in bioactivity and receptor binding capacity of tumor necrosis factor mutants, Hiroko Shibata,Haruhiko Kamada,Kyoko Kobayashi-Nishibata,Yasuo Yoshioka,Toshihide Nishibata,Yasuhiro Abe,Tetsuya Nomura,Hiromi Nabeshi,Kyoko Minowa,Yohei Mukai,Shinsaku Nakagawa,Tadanori Mayumi,Shin-ichi Tsunoda,Yasuo Tsutsumi, BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, ELSEVIER SCIENCE BV, Vol. 1774, No. 8, p. 1029-1035, 2007/08
  • Development of the valuable cell line which evaluate the bioactivity through TNFR2 using chimeric receptor strategy, Yasuhiro Abe,Yasuo Yoshioka,Tetsuya Nomura,Hiromi Nabeshi,Hiroyuki Kayamuro,Kyoko Minowa,Hiroko Shibata,Shinsaku Nakagawa,Haruhiko Kamada,Shin-Ichi Tsunoda,Yasuo Tsutsumi, CYTOKINE, ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD, Vol. 39, No. 1, p. 1-1, 2007/07
  • Site-specific PEGylation of a lysine-deficient TNF superfamily with full bioactivity, Yasuo Yoshioka,Tomohiro Morishige,Hikaru Watanabe,Aya Tanabe,Yasuhiro Abe,Yohei Mukai,Harubiko Kamada,Naoki Okada,Shinsaku Nakagawa,Yasuo Tsutsumi, CYTOKINE, ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD, Vol. 39, No. 1, p. 47-47, 2007/07
  • Role of amino acid residue 90 in bioactivity and receptor binding capacity of tumor necrosis factor mutants, Kamada Haruhiko,Tsutsumi Yasuo,Yoshioka Yasuo,Shibata Hiroko,Abe Yasuhiro,Nomura Tetsuya,Minowa Kyoko,Nabeshi Hiromi,Nakagawa Shinsaku,Tsunoda Shin-ichi, Abstracts for Annual Meeting of Japanese Proteomics Society, Japanese Proteomics Society (Japan Human Proteome Organisation), Vol. 2007, No. 0, p. 154-154, 2007
  • A strategy for efficient cross-presentation of CTL-epitope peptides leading to enhanced induction of in vivo tumor immunity, Akira Hayashi,Hisashi Wakita,Tomoaki Yoshikawa,Tsuyoshi Nakanishi,Yasuo Tsutsumi,Tadanori Mayumi,Yohei Mukai,Yasuo Yoshioka,Naoki Okada,Shinsaku Nakagawa, JOURNAL OF CONTROLLED RELEASE, ELSEVIER SCIENCE BV, Vol. 117, No. 1, p. 11-19, 2007/01
  • Interlaboratory evaluation of two enzyme-linked immunosorbent assay kits for the detection of egg, milk, wheat, buckwheat, and peanut in foods, Rieko Matsuda,Yasuo Yoshioka,Hiroshi Akiyama,Kenichi Aburatani,Yumiko Watanabe,Takashi Matsumoto,Naoki Morishita,Hidetaka Sato,Takashi Mishima,Reiko Gamo,Yasunori Kihira,Tamio Maitani, JOURNAL OF AOAC INTERNATIONAL, AOAC INTERNATIONAL, Vol. 89, No. 6, p. 1600-1608, 2006/11
  • Chondroitin sulfate intake inhibits the IgE-mediated allergic response by down-regulating Th2 responses in mice, Shinobu Sakai,Hiroshi Akiyama,Yuji Sato,Yasuo Yoshioka,Robert J. Linhardt,Yukihiro Goda,Tamio Maitani,Toshihiko Toida, JOURNAL OF BIOLOGICAL CHEMISTRY, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, Vol. 281, No. 29, p. 19872-19880, 2006/07
  • 1 食物アレルゲン(ピーナッツ,魚卵)(シンポジウム10 今注目すべきアレルゲンと病態,第18回日本アレルギー学会春季臨床大会), 穐山 浩,吉岡 靖雄,松田 りえ子,佐伯 宏樹,渡辺 一彦,宇理須 厚雄,米谷 民雄, アレルギー, 一般社団法人 日本アレルギー学会, Vol. 55, No. 3, p. 352-352, 2006
  • Profile analysis and immunoglobulin E reactivity of wheat protein hydrolysates, H Akiyama,K Sakata,Y Yoshioka,Y Murata,Y Ishihara,R Teshima,J Sawada,T Maitani, INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, KARGER, Vol. 140, No. 1, p. 36-42, 2006
  • プロシアニジンによる大腸炎発症予防効果とその作用メカニズムに関する検討, 吉岡 靖雄,穐山 浩,庄司 俊彦,滝田 聖親,神田 智正,松田 りえ子,米谷 民雄, アレルギー, (一社)日本アレルギー学会, Vol. 54, No. 8-9, p. 1102-1102, 2005/09
  • Dietary unripe apple polyphenol inhibits the development of food allergies in murine models, H Akiyama,Y Sato,T Watanabe,MH Nagaoka,Y Yoshioka,T Shoji,T Kanda,K Yamada,M Totsuka,R Teshima,J Sawada,Y Goda,T Maitani, FEBS LETTERS, ELSEVIER SCIENCE BV, Vol. 579, No. 20, p. 4485-4491, 2005/08
  • Functionalization of tumor necrosis factor-alpha using phage display technique and PEGylation improves its antitumor therapeutic window, H Shibata,Y Yoshioka,S Ikemizu,K Kobayashi,Y Yamamoto,Y Mukai,T Okamoto,M Taniai,M Kawamura,Y Abe,S Nakagawa,T Hayakawa,S Nagata,Y Yamagata,T Mayumi,H Kamada,Y Tsutsumi, CLINICAL CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, Vol. 10, No. 24, p. 8293-8300, 2004/12
  • Optimal construction of non-immune scFv phage display libraries from mouse bone marrow and spleen established to select specific scFvs efficiently binding to antigen, T Okamoto,Y Mukai,Y Yoshioka,H Shibata,M Kawamura,Y Yamamoto,S Nakagawa,H Kamada,T Hayakawa,T Mayumi,Y Tsutsumi, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC ELSEVIER SCIENCE, Vol. 323, No. 2, p. 583-591, 2004/10
  • Effective accumulation of poly(vinylpyrrolidone-co-vinyl laurate) into the spleen., Yasuo Yoshioka,Yasuo Tsutsumi,Yohei Mukai,Hiroko Shibata,Takayuki Okamoto,Yoshihisa Kaneda,Shin-ichi Tsunoda,Haruhiko Kamada,Keiichi Koizumi,Yoko Yamamoto,Yu Mu,Hiroshi Kodaira,Keiko Sato-Kamada,Shinsaku Nakagawa,Tadanori Mayumi, Journal of biomedical materials research. Part A, Vol. 70, No. 2, p. 219-23, 2004/08/01
  • The targeting of anionized polyvinylpyrrolidone to the renal system, H Kodaira,Y Tsutsumi,Y Yoshioka,H Kamada,Y Kaneda,Y Yamamoto,S Tsunoda,T Okamoto,Y Mukai,H Shibata,S Nakagawa,T Mayumi, BIOMATERIALS, ELSEVIER SCI LTD, Vol. 25, No. 18, p. 4309-4315, 2004/08
  • Effective accumulation of poly(vinylpyrrolidone-co-vinyl laurate) into the spleen, Y Yoshioka,Y Tsutsumi,Y Mukai,H Shibata,T Okamoto,Y Kaneda,S Tsunoda,H Kamada,K Koizumi,Y Yamamoto,Y Mu,H Kodaira,K Sato-Kamada,S Nakagawa,T Mayumi, JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, WILEY-LISS, Vol. 70A, No. 2, p. 219-223, 2004/08
  • The use of PVP as a polymeric carrier to improve the plasma half-life of drugs, Y Kaneda,Y Tsutsumi,Y Yoshioka,H Kamada,Y Yamamoto,H Kodaira,S Tsunoda,T Okamoto,Y Mukai,H Shibata,S Nakagawa,T Mayumi, BIOMATERIALS, ELSEVIER SCI LTD, Vol. 25, No. 16, p. 3259-3266, 2004/07
  • Design of a pH-sensitive polymeric carrier for drug release and its application in cancer therapy, H Kamada,Y Tsutsumi,Y Yoshioka,Y Yamamoto,H Kodaira,S Tsunoda,T Okamoto,Y Mukai,H Shibata,S Nakagawa,T Mayumi, CLINICAL CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, Vol. 10, No. 7, p. 2545-2550, 2004/04
  • Poly(vinylpyrrolidone-co-dimethyl maleic acid) as a novel renal targeting carrier, Y Yamamoto,Y Tsutsumi,Y Yoshioka,H Kamada,K Sato-Kamada,T Okamoto,Y Mukai,H Shibata,S Nakagawa,T Mayumi, JOURNAL OF CONTROLLED RELEASE, ELSEVIER SCIENCE BV, Vol. 95, No. 2, p. 229-237, 2004/03
  • Optimal site-specific PEGylation of mutant TNF-alpha improves its antitumor potency, Y Yoshioka,Y Tsutsumi,S Ikemizu,Y Yamamoto,H Shibata,T Nishibata,Y Mukai,T Okamoto,M Taniai,M Kawamura,Y Abe,S Nakagawa,S Nagata,Y Yamagata,T Mayumi, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC ELSEVIER SCIENCE, Vol. 315, No. 4, p. 808-814, 2004/03
  • Selective enhancer of tumor vascular permeability for optimization of cancer chemotherapy, Y Yoshioka,Y Tsutsumi,H Kamada,T Kihira,S Tsunoda,Y Yamamoto,T Okamoto,H Shibata,Y Mukai,M Taniai,T Shimizu,M Kawamura,Y Abe,S Nakagawa,T Mayumi, BIOLOGICAL & PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOC JAPAN, Vol. 27, No. 3, p. 437-439, 2004/03
  • Combination effects of complement regulatory proteins and anti-complement polymer., Yasuo Yoshioka,Ryo Suzuki,Takayuki Okamoto,Naoki Okada,Yohei Mukai,Hiroko Shibata,Yasuo Tsutsumi,Natsuki Dohi,Noriko Okada,Shinsaku Nakagawa,Tadanori Mayumi, Biochimica et biophysica acta, Vol. 1624, No. 1-3, p. 54-9, 2003/12/05
  • Combination effects of complement regulatory proteins and anti-complement polymer, Yasuo Yoshioka,Ryo Suzuki,Takayuki Okamoto,Naoki Okada,Yohei Mukai,Hiroko Shibata,Yasuo Tsutsumi,Natsuki Dohi,Noriko Okada,Shinsaku Nakagawa,Tadanori Mayumi, Biochimica et Biophysica Acta - General Subjects, Elsevier, Vol. 1624, No. 1-3, p. 54-59, 2003/12/05
  • Anti-angiogenic effects of dimethyl sulfoxide on endothelial cells, K Koizumi,Y Tsutsumi,Y Yoshioka,M Watanabe,T Okamoto,Y Mukai,S Nakagawa,T Mayumi, BIOLOGICAL & PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOC JAPAN, Vol. 26, No. 9, p. 1295-1298, 2003/09
  • Incorporation of adult organ-derived endothelial cells into tumor blood vessel., Koizumi K,Tsutsumi Y,Kamada H,Yoshioka Y,Watanabe M,Yamamoto Y,Okamoto T,Mukai Y,Nakagawa S,Tani Y,Mayumi T, Biochem Biophys Res Commun., 2003/07
  • Site-specific PEGylation of a lysine-deficient TNF-alpha with full bioactivity, Y Yamamoto,Y Tsutsumi,Y Yoshioka,T Nishibata,K Kobayashi,T Okamoto,Y Mukai,T Shimizu,S Nakagawa,S Nagata,T Mayumi, NATURE BIOTECHNOLOGY, NATURE PUBLISHING GROUP, Vol. 21, No. 5, p. 546-552, 2003/05
  • A novel cytomedical vehicle capable of protecting cells against complement, Y Yoshioka,R Suzuki,H Oka,N Okada,T Okamoto,T Yoshioka,Y Mukai,H Shibata,Y Tsutsumi,S Nakagawa,J Miyazaki,T Mayumi, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC ELSEVIER SCIENCE, Vol. 305, No. 2, p. 353-358, 2003/05
  • Synthesis of a poly(vinylpyrrolidone-co-dimethyl maleic anhydride) co-polymer and its application for renal drug targeting, H Kamada,Y Tsutsumi,K Sato-Kamada,Y Yamamoto,Y Yoshioka,T Okamoto,S Nakagawa,S Nagata,T Mayumi, NATURE BIOTECHNOLOGY, NATURE PUBLISHING GROUP, Vol. 21, No. 4, p. 399-404, 2003/04
  • Development of a novel cytomedical treatment that can protect entrapped cells from host humoral immunity, R Suzuki,Y Yoshioka,E Kitano,T Yoshioka,H Oka,T Okamoto,N Okada,Y Tsutsumi,S Nakagawa,J Miyazaki,H Kitamura,T Mayumi, CELL TRANSPLANTATION, COGNIZANT COMMUNICATION CORP, Vol. 11, No. 8, p. 787-797, 2002

Misc.

  • 効果的ながん免疫療法の実現に向けた免疫賦活化核酸搭載脂質ナノ粒子の開発, 宗像 理紗,小俣 大樹,小山 正平,岡田 欣晃,吉岡 靖雄,青枝 大貴,鈴木 亮, バイオイメージング, 日本バイオイメージング学会, Vol. 29, No. 1-2, p. 32-32, 2020/11
  • CpG核酸搭載ナノ粒子を利用した抗腫瘍免疫誘導に関する検討, 宗像理紗,小俣大樹,丸山一雄,谷本佳彦,長谷田泰成,小山正平,吉岡靖雄,吉岡靖雄,岡田欣晃,青枝大貴,鈴木亮, 日本薬剤学会年会講演要旨集(Web), Vol. 34年会, p. 148-148, 2019/05
  • ヒストン脱アセチル化酵素阻害剤MS-275ががん細胞の血管外遊走に与える影響の解析, 樫尾 泰斗,石破 亮斗,森田 真綾,木下 真由美,小山 正平,鈴木 亮,吉岡 靖雄,青枝 大貴,岡田 欣晃,土井 健史, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 139年会, No. 3, p. 86-86, 2019/03
  • 免疫賦活化核酸搭載脂質ナノ粒子による抗腫瘍メカニズム解析, 宗像理紗,小俣大樹,谷本佳彦,長谷田泰成,小山正平,吉岡靖雄,吉岡靖雄,岡田欣晃,丸山一雄,青枝大貴,鈴木亮, 日本薬学会年会要旨集(CD-ROM), Vol. 139年会, No. 4, p. 71-71, 2019/03
  • CpG核酸搭載脂質ナノ粒子の細胞内取込経路解析, 青木恵理子,宗像理紗,小俣大樹,長谷田泰成,小山正平,吉岡靖雄,吉岡靖雄,岡田欣晃,丸山一雄,青枝大貴,鈴木亮, 日本薬学会関東支部大会講演要旨集, Vol. 63rd, 2019
  • 免疫賦活化核酸搭載脂質ナノ粒子の開発とその有効性・安全性評価, 川元愛実,宗像理紗,小俣大樹,谷本佳彦,長谷田泰成,小山正平,吉岡靖雄,吉岡靖雄,岡田欣晃,丸山一雄,青枝大貴,鈴木亮, 日本薬学会関東支部大会講演要旨集, Vol. 62nd, 2018/09/10
  • PD-L1 siRNAによる核酸治療の可能性(A possibility of nucleic acid medicine using PD-L1 siRNA), 久保田 結衣,吉岡 靖雄,横山 雄起,呉 しん,武田 力,山本 浩文, 日本癌学会総会記事, 日本癌学会, Vol. 77回, p. 1722-1722, 2018/09
  • 効果的がん免疫療法の確立に向けた免疫賦活化核酸搭載ナノ粒子の開発, 宗像 理紗,鈴木 亮,小俣 大樹,青枝 大貴,長谷田 泰成,小山 正平,吉岡 靖雄,岡田 欣晃,丸山 一雄, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 138年会, No. 4, p. 75-75, 2018/03
  • 効果的がん免疫療法の確立に向けた免疫賦活化核酸搭載ナノ粒子の開発, 宗像理紗,鈴木亮,小俣大樹,青枝大貴,長谷田泰成,小山正平,吉岡靖雄,吉岡靖雄,岡田欣晃,丸山一雄, 日本薬学会年会要旨集(CD-ROM), (公社)日本薬学会, Vol. 138th, No. 4, p. ROMBUNNO.27V‐pm01S-75, 2018/03
  • D35と脂質複合体による抗腫瘍効果, 谷本佳彦,宗像理紗,長彰翁,孟潔,長谷田泰成,吉岡靖雄,岡田欣晃,小山正平,鈴木亮,青枝大貴, 日本ワクチン学会学術集会プログラム・抄録集, Vol. 22nd, 2018
  • Nano-safety Research: Examining the Associations among the Biological Effects of Nanoparticles and Their Physicochemical Properties and Kinetics, Kazuma Higashisaka,Kazuya Nagano,Yasuo Yoshioka,Yasuo Tsutsumi, BIOLOGICAL & PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOC JAPAN, Vol. 40, No. 3, p. 243-248, 2017/03
  • Allergic Responses induced by the immunomodulatory effects of Nanomaterials upon Skin exposure, Yasuo Yoshioka,Etsushi Kuroda,Toshiro Hirai,Yasuo Tsutsumi,Ken J. Ishii, FRONTIERS IN IMMUNOLOGY, FRONTIERS MEDIA SA, Vol. 8, 2017/02
  • 血管内皮細胞特異的受容体Robo4が癌の増殖,転移,血管透過性に与える影響の解析, 石破亮祐,樫尾泰斗,吉岡靖雄,吉岡靖雄,鈴木亮,小山正平,青枝大貴,岡田欣晃,土井健史, 日本心血管内分泌代謝学会学術総会プログラム及び抄録集, Vol. 21st, 2017
  • ナノ粒子の安全科学研究, 東阪和馬,吉岡靖雄,堤 康央, ぶんせき, p. 404-408, 2016/10
  • Effect of nanomaterials on permeability of placental barrier focused on intercellular space, SHIMIZU Yuki,HIGASHISAKA Kazuma,AOYAMA Michihiko,NAMBA Yuki,IZUMI Masahiro,NAGANO Kazuya,YOSHIOKA Yasuo,TSUTSUMI Yasuo, Annual Meeting of the Japanese Society of Toxicology, The Japanese Society of Toxicology, Vol. 43, p. O-37, 2016
  • The effects of silver nanoparticles on DNA methyltransferase, MAKI Ayaka,HIGASHISAKA Kazuma,AOYAMA Michihiko,NISHIKAWA Yuki,ISHIZAKA Takuya,KASAHARA Junpei,NAGANO Kazuya,YOSHIOKA Yasuo,TSUTSUMI Yasuo, Annual Meeting of the Japanese Society of Toxicology, The Japanese Society of Toxicology, Vol. 43, p. O-35, 2016
  • The analysis of the pathogenesis of metal allergy in the animal model mediated by nanoparticles focused on the adjuvant, IZUMI Natsumi,YOSHIOKA Yasuo,HIRAI Toshiro,HANDA Takayuki,ETO Syun-ichi,AOYAMA Michihiko,NAGANO Kazuya,HIGASHISAKA Kazuma,TSUTSUMI Yasuo, Annual Meeting of the Japanese Society of Toxicology, The Japanese Society of Toxicology, Vol. 43, p. O-36, 2016
  • The effect of autophagy inhibition on uptake of nanomaterials, AOYAMA Michihiko,ISHIMOTO Rio,HIRAI Haruna,NAGANO Kazuya,SAITO Shigeru,HIGASHISAKA Kazuma,YOSHIOKA Yasuo,TSUTSUMI Yasuo, Annual Meeting of the Japanese Society of Toxicology, The Japanese Society of Toxicology, Vol. 43, p. P-9, 2016
  • The basic analysis on intracellular movement of nanoparticles, HIRAI Haruna,HIGASHISAKA Kazuma,AOYAMA Michihiko,ARAI Yoshiyuki,ISHIMOTO Rio,NAGANO Kazuya,NAGAI Takeharu,YOSHIOKA Yasuo,TSUTSUMI Yasuo, Annual Meeting of the Japanese Society of Toxicology, The Japanese Society of Toxicology, Vol. 43, p. P-212, 2016
  • The establishment of single particle ICP-MS to determine the metal nanoparticles, ISHIZAKA Takuya,HIGASHISAKA Kazuma,AOYAMA Michihiko,NISHIKAWA Yuki,MAKI Ayaka,KASAHARA Junpei,NAGANO Kazuya,YOSHIOKA Yasuo,TSUTSUMI Yasuo, Annual Meeting of the Japanese Society of Toxicology, The Japanese Society of Toxicology, Vol. 43, p. P-11, 2016
  • Reproductive and developmental effects of nanomaterials, Yuki Morishita,Yasuo Yoshioka,Kazuma Higashisaka,Yasuo Tsutsumi, Biological Effects of Fibrous and Particulate Substances, Springer Japan, p. 77-101, 2015/10/26
  • Neutrophil depletion increase silica nanoparticle-induced placental cellular damage, K. Higashisaka,Y. Iwahara,I. Yanagihara,S. Saito,Y. Yoshioka,Y. Tsutsumi, TOXICOLOGY LETTERS, ELSEVIER IRELAND LTD, Vol. 238, No. 2, p. S206-S206, 2015/10
  • Applications and Safety of Nanomaterials Used in the Food Industry, Higashisaka Kazuma,Yoshioka Yasuo,Tsutsumi Yasuo, Food Safety, Food Safety Commission, Cabinet Office, Government of Japan, Vol. 3, No. 2, p. 39-47, 2015/06
  • Effects of nanoparticles on DNA methylation on alveolar epithelial cells, MAKI Ayaka,HIGASHISAKA Kazuma,NISHIKAWA Yuki,YOSHIOKA Yasuo,TSUTSUMI Yasuo, Annual Meeting of the Japanese Society of Toxicology, The Japanese Society of Toxicology, Vol. 42, p. P-94, 2015
  • The identification of a cell type that concerned about the pathogenesis of metal allergy in animal model mediated by metal nanoparticles, IZUMI Natsumi,YOSHIOKA Yasuo,HIRAI Toshiro,NISHIJIMA Nobuo,HANDA Takayuki,HIGASHISAKA Kazuma,TSUTSUMI Yasuo, Annual Meeting of the Japanese Society of Toxicology, The Japanese Society of Toxicology, Vol. 42, p. P-93, 2015
  • A study on the elucidation of the chronic exposure to nanoparticles –the evaluation of proinflammatory activities induced by daily exposure to silver nanoparticles-, NISHIKAWA Yuki,HIGASHISAKA Kazuma,MAKI Ayaka,YOSHIOKA Yasuo,TSUTSUMI Yasuo, Annual Meeting of the Japanese Society of Toxicology, The Japanese Society of Toxicology, Vol. 42, p. O-2, 2015
  • Transgenerational effects of nanomaterials through paternal exposure, NAMBA Yuki,YOSHIOKA Yasuo,MORISHITA Yuki,TAKIMURA Yuya,SHIMIZU Yuki,AGO Yukio,TAKUMA Kazuhiro,MATSUDA Toshio,HIGASHISAKA Kazuma,TSUTSUMI Yasuo, Annual Meeting of the Japanese Society of Toxicology, The Japanese Society of Toxicology, Vol. 42, p. O-1, 2015
  • The mechanism analysis of silica nanoparticles-induced acute toxicity focused on platelet, HANDA Takayuki,YOSHIOKA Yasuo,HIRAI Toshiro,NISHIJIMA Nobuo,IZUMI Natsumi,HIGASHISAKA Kazuma,TSUTSUMI Yasuo, Annual Meeting of the Japanese Society of Toxicology, The Japanese Society of Toxicology, Vol. 42, p. P-92, 2015
  • Effect of nanomaterial on permeability of blood-placenta barrier, SHIMIZU Yuki,YOSHIOKA Yasuo,MORISHITA Yuki,TAKIMURA Yuya,NAMBA Yuki,YANAGIHARA Itaru,HIGASHISAKA Kazuma,TSUTSUMI Yasuo, Annual Meeting of the Japanese Society of Toxicology, The Japanese Society of Toxicology, Vol. 42, p. P-88, 2015
  • Optimization of an immune method to shorten time for inducing antibodies in mice, T. Mori,K. Nagano,K. Higashisaka,Y. Yoshioka,H. Kamada,S. Tsunoda,Y. Tsutsumi, MOLECULAR BIOLOGY OF THE CELL, AMER SOC CELL BIOLOGY, Vol. 26, 2015
  • ナノ白金粒子と医薬品成分・化学物質の相互作用に関する検討, 大坊萌美,磯田勝広,油科香里,長谷川知也,吉岡靖雄,堤康央,石田功, 日本薬学会年会要旨集(CD-ROM), Vol. 135th, 2015
  • Effect of toxicity and drug interactions by nano-platinum particles, ISODA Katsuhiro,DAIBO Tomomi,YUSHINA Kaori,TAIRA Yuitiro,TAIRA Ikuko,YOSHIOKA Yasuo,TSUTSUMI Yasuo,ISHIDA Isao, Annual Meeting of the Japanese Society of Toxicology, The Japanese Society of Toxicology, Vol. 42, No. 0, p. P-96, 2015
  • Single particle tracking method for the analysis of intracellular movement of the silica nanoparticles, Michihiko Aoyama,Yasuo Yoshioka,Yoshiyuki Arai,Rio Ishimoto,Shin-ichi Tsunoda,Kazuma Higashisaka,Takeharu Nagai,Yasuo Tsutsumi, TOXICOLOGY LETTERS, ELSEVIER IRELAND LTD, Vol. 229, p. S186-S187, 2014/09
  • The contribution of silica nanoparticles-induced neutrophilia to pregnancy complications in mice, Kazuma Higashisaka,Akiyoshi Kunieda,Yuki Iwahara,Kota Tanaka,Shin-ichi Tsunoda,Yasuo Yoshioka,Yasuo Tsutsumi, TOXICOLOGY LETTERS, ELSEVIER IRELAND LTD, Vol. 229, p. S193-S193, 2014/09
  • Expression of Annexin A4 regulates cisplatin-susceptibility in malignant mesothelioma, K. Nagano,T. Yamashita,M. Inoue,K. Higashisaka,Y. Yoshioka,Y. Abe,Y. Mukai,H. Kamada,Y. Tsutsumi,S. Tsunoda, EUROPEAN JOURNAL OF CANCER, ELSEVIER SCI LTD, Vol. 50, p. S190-S190, 2014/07
  • Silver nanoparticles induce silver nanoparticle-specific allergic responses, Toshiro Hirai,Yasuo Yoshioka,Ko-ichi Ichihashi,Takahide Mori,Nobuo Nishijima,Takayuki Handa,Hideki Takahashi,Shin-ichi Tsunoda,Kazuma Higashisaka,Yasuo Tsutsumi, JOURNAL OF IMMUNOLOGY, AMER ASSOC IMMUNOLOGISTS, Vol. 192, 2014/05
  • Fullerene C60 derivatives suppress the acquired immune responses, Yasuo Yoshioka,Asako Udaka,Toshiro Hirai,Hisae Aoshima,Ken Kokubo,Takumi Oshima,Tomoyuki Ohe,Tadahiko Mashino,Shin-ichi Tsunoda,Kazuma Higashisaka,Yasuo Tsutsumi, JOURNAL OF IMMUNOLOGY, AMER ASSOC IMMUNOLOGISTS, Vol. 192, 2014/05
  • ナノ白金粒子の薬物相互作用に関する検討, 磯田勝広,油科香里,赤浦広紀,西村哲治,手塚雅勝,吉岡靖雄,堤康央,石田功, 日本薬学会年会要旨集(CD-ROM), Vol. 134th, 2014
  • The effect of lactational exposure to silver nanoparticles on emotional functions of infants, MORISHITA Yuki,MIYAKAWA Tsuyoshi,HIGASHISAKA Kazuma,TSUTSUMI Yasuo,YOSHIOKA Yasuo,TAKIMURA Yuya,NOJIRI Nao,TAKAO Keizo,TAKUMA Kazuhiro,AGO Yukio,TSUNODA Shin-ichi,MATSUDA Toshio, Annual Meeting of the Japanese Society of Toxicology, The Japanese Society of Toxicology, Vol. 41, No. 0, p. P-19, 2014
  • The transitivity of silver nanoparticles to the infant through the milk, TAKIMURA Yuya,MIYAGAWA Tsuyoshi,HIGASHISAKA Kazuma,TSUTSUMI Yasuo,YOSHIOKA Yasuo,MORISHITA Yuki,NOJIRI Nao,TAKAO Keizo,TAKUMA Kazuhiro,AGO Yukio,TSUNODA Shin-ichi,MATSUDA Toshio, Annual Meeting of the Japanese Society of Toxicology, The Japanese Society of Toxicology, Vol. 41, No. 0, p. O-30, 2014
  • 腫瘍血管マーカーRobo4に対する細胞内侵入抗体の抗体薬物複合体としての有用性評価, 向洋平,吉川舞,岡田欣晃,WILLIAM Aird,吉岡靖雄,角田慎一,堤康央,岡田直貴,土井健史,中川晋作, 日本DDS学会学術集会プログラム予稿集, 日本DDS学会, Vol. 29回, p. 155-155, 2013/06
  • 非晶質ナノシリカの妊娠期曝露が仔の情動機能へ及ぼす影響探索, 森下裕貴,吉岡靖雄,高雄啓三,吾郷由希夫,佐藤宏祐,野尻奈央,田中智大,田熊一敞,角田慎一,松田敏夫,宮川剛,東阪和馬,堤康央, J Toxicol Sci, Vol. 38, No. Supplement, 2013/06
  • The effects of oral administration of silica nanoparticles on immunologic response to the food antigen, Kazuki Misato,Yasuo Yoshioka,Miyuki Uji,Asako Udaka,Takahide Mori,Manami Yamaguchi,Toshiro Hirai,Tokuyuki Yoshida,Hiromi Nabeshi,Tomoaki Yoshikawa,Shin-ichi Tsunoda,Kazuma Higashisaka,Yasuo Tsutsumi, JOURNAL OF IMMUNOLOGY, AMER ASSOC IMMUNOLOGISTS, Vol. 190, 2013/05
  • The size effects of amorphous silica nanoparticles on atopic dermatitis-like skin lesion, Hideki Takahashi,Yasuo Yoshioka,Toshiro Hirai,Ko-ichi Ichihashi,Nobuo Nishijima,Tokuyuki Yoshida,Hiromi Nabeshi,Tomoaki Yoshikawa,Shin-ichi Tsunoda,Kazuma Higashisaka,Yasuo Tsutsumi, JOURNAL OF IMMUNOLOGY, AMER ASSOC IMMUNOLOGISTS, Vol. 190, 2013/05
  • 認知機能に着目した非晶質ナノシリカの妊娠期曝露による次世代影響評価, 森下裕貴,吉岡靖雄,高雄啓三,吾郷由希夫,佐藤宏祐,野尻奈央,田熊一敞,角田慎一,鍋師裕美,吉川友章,松田敏夫,宮川剛,堤康央, J Toxicol Sci, 日本毒性学会, Vol. 37, No. Supplement 1, p. S224-135, 2012/07
  • Safety assessment of sub-nano platinum-2-Hazards on neonates, Yuki Morishita,Yuki Morishita,Yasuo Yoshioka,Hiroyoshi Satoh,Nao Nojiri,Hiromi Nabeshi,Tomoaki Yoshikawa,Yasuo Tsutsumi, TOXICOLOGY LETTERS, ELSEVIER IRELAND LTD, Vol. 211, p. S198-S199, 2012/06
  • Safety assessment of sub-nano platinum-1-Hazards on fetus, Yasuo Yoshioka,Yasuo Yoshioka,Hiroyoshi Satoh,Yuki Morishita,Nao Nojiri,Hiromi Nabeshi,Tomoaki Yoshikawa,Yasuo Tsutsumi, TOXICOLOGY LETTERS, ELSEVIER IRELAND LTD, Vol. 211, p. S198-S198, 2012/06
  • Hazard identification of nanosilica particles using atopic dermatitis model mouse, Toshiro Hirai,Tomoaki Yoshikawa,Tokuyuki Yoshida,Ko-Ichi Ichihashi,Hideki Takahashi,Hiromi Nabeshi,Yasuo Yoshioka,Yasuo Tsutsumi, TOXICOLOGY LETTERS, ELSEVIER IRELAND LTD, Vol. 211, p. S199-S199, 2012/06
  • 癌ターゲティング療法における腫瘍血管内皮細胞特異的な細胞内侵入抗体の有用性評価, 柳澤有紀,向洋平,吉川舞,岡田欣晃,吉岡靖雄,角田慎一,堤康央,岡田直貴,土井健史,中川晋作, 日本DDS学会学術集会プログラム予稿集, 日本DDS学会, Vol. 28回, p. 161-161, 2012/06
  • Carbon Nanomaterials: Efficacy and Safety for Nanomedicine, Takuya Yamashita,Kohei Yamashita,Hiromi Nabeshi,Tomoaki Yoshikawa,Yasuo Yoshioka,Shin-ichi Tsunoda,Yasuo Tsutsumi, MATERIALS, MDPI AG, Vol. 5, No. 2, p. 350-363, 2012/02
  • Tumor-targeting CTL expressing a single-chain Fv specific for VEGFR2 (vol 394, pg 54, 2010), Naoko Kanagawa,Tatsuya Yanagawa,Yohei Mukai,Yasuo Yoshioka,Naoki Okada,Shinsaku Nakagawa, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC ELSEVIER SCIENCE, Vol. 417, No. 3, p. 1106-1106, 2012/01
  • Quantifying the biodistribution of nanoparticles, Yasuo Tsutsumi,Yasuo Yoshioka, NATURE NANOTECHNOLOGY, NATURE PUBLISHING GROUP, Vol. 6, No. 12, p. 755-755, 2011/12
  • 急性ホウ酸中毒に対する血液浄化療法の有効性の検討, 桂木 慎一,松本 直也,山川 一馬,姜 晋求,吉岡 靖雄,鍋師 裕美,吉川 友章,小倉 裕司,鍬方 安行,堤 康央,嶋津 岳士, 中毒研究, (株)へるす出版, Vol. 24, No. 4, p. 353-354, 2011/12
  • Development of a novel DDS for site-specific PEGylated proteins, Yoshioka Y,Tsunoda S,Tsutsumi Y, Chem. Cent. J. (Chemistry Central Journal), 2011/12
  • Quantifying the biodistribution of nanoparticles, Xiao He,Zhiyong Zhang,Jinsen Liu,Yuhui Ma,Peng Zhang,Yuanyuan Li,Zhenqiang Wu,Yuliang Zhao,Zhifang Chai, NATURE NANOTECHNOLOGY, NATURE PUBLISHING GROUP, Vol. 6, No. 12, p. 755-755, 2011/12
  • Original report abstracts of 36th annual meeting: Biodistribution analysis of amorphous nanosilicas as nano-safety assessment, Journal of Japanese Cosmetic Science Society, Vol. 35, No. 3, p. 221-223, 2011/09
  • VEGFR2に対する細胞内侵入抗体は優れた抗癌剤送達キャリアである(Cell-internalizing monoclonal antibody against VEGFR2 is a potent anti-cancer agent carrier), 吉川 舞,向 洋平,角田 慎一,堤 康央,吉岡 靖雄,岡田 直貴,中川 晋作, 日本癌学会総会記事, 日本癌学会, Vol. 70回, p. 441-441, 2011/09
  • Effect of surface properties of nanosilica on their in vitro safety, M. Uji,T. Yoshikawa,T. Yoshida,T. Hirai,H. Nabeshi,Y. Yoshioka,N. Itoh,Y. Tsutsumi, TOXICOLOGY LETTERS, ELSEVIER IRELAND LTD, Vol. 205, p. S289-S289, 2011/08
  • The safety assessment of amorphous nanosilica following dermal exposure, T. Hirai,T. Yoshikawa,T. Yoshida,M. Uji,H. Nabeshi,Y. Yoshioka,N. Itoh,Y. Tsutsumi, TOXICOLOGY LETTERS, ELSEVIER IRELAND LTD, Vol. 205, p. S283-S283, 2011/08
  • In vitro evaluation of the embryotoxic potency of amorphous nanosilica, T. Ogura,Y. Yoshioka,K. Yamashita,K. Kawabata,H. Mizuguchi,T. Yoshikawa,N. Itoh,Y. Tsutsumi, TOXICOLOGY LETTERS, ELSEVIER IRELAND LTD, Vol. 205, p. S251-S251, 2011/08
  • Development of biomarkers for ensuring safety of nanomaterials, K. Higashisaka,Y. Yoshioka,K. Yamashita,Y. Morishita,H. Nabeshi,S. Tsunoda,N. Itoh,Y. Tsutsumi, TOXICOLOGY LETTERS, ELSEVIER IRELAND LTD, Vol. 205, p. S64-S64, 2011/08
  • Postnatal effects of prenatal treatment of amorphous nanosilica, Y. Morishita,Y. Yoshioka,K. Takao,K. Yamashita,T. Yoshikawa,N. Itoh,T. Miyakawa,Y. Tsutsumi, TOXICOLOGY LETTERS, ELSEVIER IRELAND LTD, Vol. 205, No. 0, p. S285-S286, 2011/08
  • 香粧品分野におけるナノマテリアルの安全性に関する国内外の報告, 森下裕貴,鍋師裕美,吉川友章,吉岡靖雄,堤 康央, コスメティックステージ, 2011/08
  • 【インフラマソーム】インフラマソームの活性とシリカ粒子の性状, 吉岡 靖雄,中川 晋作,堤 康央, 生体の科学, (公財)金原一郎記念医学医療振興財団, Vol. 62, No. 3, p. 228-232, 2011/06
  • 金磁性ナノ粒子を応用した新規MRI腫瘍造影剤の開発, 伴野由季,向洋平,吉川舞,小島拓記,清野智史,山本孝夫,森田将史,犬伏俊郎,吉岡靖雄,岡田直貴,中川晋作, 日本薬剤学会年会講演要旨集, (公社)日本薬剤学会, Vol. 26年会, p. 94-94, 2011/05
  • 標的分子特異的な細胞内薬物送達を目指した細胞内侵入抗体の基礎的特性評価, 吉川舞,向洋平,堤康央,角田慎一,吉岡靖雄,岡田直貴,中川晋作, 日本薬剤学会年会講演要旨集, (公社)日本薬剤学会, Vol. 26年会, p. 102-102, 2011/05
  • 食品分野におけるナノテクノロジーの安全性, 鍋師裕美,吉岡靖雄,吉川友章,堤 康央, 食品衛生研究, Vol. 61, No. 5, p. 27-34, 2011/05
  • 線虫C. elegansをモデルとしたナノシリカの生態影響評価, 井口 綾子,皆越 緑,吉 赫哲,吉岡 靖雄,堤 康央,冨永 伸明,有薗 幸司, 日本薬学会第131回年回（静岡）, 2011/03
  • 抗体プロテオミクス技術による肺がんリンパ節転移関連分子の同定と機能解析, 長野一也,今井直,山下琢矢,渡邊貴信,金崎聡一郎,前田祐香,鍋師裕美,吉川友章,吉岡靖雄,井上雅己,趙秀麗,阿部康弘,鎌田春彦,中川晋作,堤康央,角田慎一, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 131年会, No. 4, p. 294-294, 2011/03
  • Safety evaluation study of nanomaterials aimed at the promotion of the social reception., Gene. Environ, 2011/03
  • NanoSafety Studies of Nanomaterials about Biodistribution and Immunotoxicity, Yasuo Yoshioka, YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, PHARMACEUTICAL SOC JAPAN, Vol. 131, No. 2, p. 221-224, 2011/02
  • Recent Topics of NanoTox Studies for Their Safety Foreword, Yasuo Tsutsumi,Yasuo Yoshioka, YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, PHARMACEUTICAL SOC JAPAN, Vol. 131, No. 2, p. 193-194, 2011/02
  • Solution of the structure of the TNF-TNFR2 complex, Yohei Mukai,Teruya Nakamura,Mai Yoshikawa,Yasuo Yoshioka,Shin-ichi Tsunoda,Shinsaku Nakagawa,Yuriko Yamagata,Yasuo Tsutsumi, ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES, INT UNION CRYSTALLOGRAPHY, Vol. 67, p. C308-C308, 2011
  • To the Editor, Yasuo Tsutsumi,Yasuo Yoshioka, Nature Nanotechnology, Nature Publishing Group, Vol. 6, No. 12, 2011
  • Safety evaluation study of nanomaterials aimed at promoting their acceptance by society, Hiromi Nabeshi,Tomoaki Yoshikawa,Yasuo Yoshioka,Yasuo Tsutsumi, Genes and Environment, Vol. 33, No. 1, p. 21-26, 2011
  • MUTANT TNF ELICITS MUCOSAL AND SYSTEMIC IMMUNITY AGAINST HIV-1 AND INFLUENZA VIRUS, Yasuhiro Abe,Hiroyuki Kayamuro,Yasuo Yoshioka,Kazuhumi Katayama,Haruhiko Kamada,Tetsuya Nomura,Takachika Hiroi,Shin-nichi Tsunoda,Yasuo Tsutsumi, ADVANCES IN TNF FAMILY RESEARCH, SPRINGER-VERLAG BERLIN, Vol. 691, p. 801-802, 2011
  • IDENTIFICATION OF NEW CANDIDATES AS MUCOSAL VACCINE ADJUVANT IN TNF SUPERFAMILY CYTOKINES, Hiroyuki Kayamuro,Yasuo Yoshioka,Yasuhiro Abe,Kazufumi Katayama,Haruhiko Kamada,Tetsuya Nomura,Takachika Hiroi,Shin-ichi Tsunoda,Yasuo Tsutsumi, ADVANCES IN TNF FAMILY RESEARCH, SPRINGER-VERLAG BERLIN, Vol. 691, p. 685-685, 2011
  • DEVELOPMENT OF A NOVEL METHOD USING PHAGE DISPLAY, GENE SHUFFLING AND IMPROVED RECEPTOR SELECTIVITY TO PRODUCE MUTANT TNFS, Tetsuya Nomura,Yasuhiro Abe,Yasuo Yoshioka,Hiroyuki Kayamuro,Hiroko Shibata,Yohei Mukai,Shin-ichi Tsunoda,Yasuo Tsutsumi, ADVANCES IN TNF FAMILY RESEARCH, SPRINGER-VERLAG BERLIN, Vol. 691, p. 802-802, 2011
  • ANTI-INFLAMMATORY EFFECTS OF A NOVEL TNFR1-SELECTIVE ANTAGONISTIC TNF MUTANT ON ESTABLISHED MURINE COLLAGEN-INDUCED ARTHRITIS, Shin-ichi Tsunoda,Yasuhiro Abe,Tetsuya Nomura,Hiroko Shibata,Yasuo Yoshioka,Haruhiko Kamada,Yasuo Tsutsumi, ADVANCES IN TNF FAMILY RESEARCH, SPRINGER-VERLAG BERLIN, Vol. 691, p. 803-803, 2011
  • Identification of New Candidates as Mucosal Vaccine Adjuvant in TNF Family Cytokines, Hiroyuki Kayamuro,Yasuo Yoshioka,Yasuhiro Abe,Kazufumi Katayama,Shuhei Arita,Tetsuya Nomura,Tomoaki Yoshikawa,Norio Itoh,Haruhiko Kamada,Shin-ichi Tsunoda,Yasuo Tsutsumi, ADVANCES IN TNF FAMILY RESEARCH, SPRINGER-VERLAG BERLIN, Vol. 691, p. 299-304, 2011
  • Safety analysis of newly-created nanomaterials for developing safe and convenience society based on innovative technologies, Vol. 62, No. 4, p. 52-56, 2010/10
  • Cell-penetrating Peptides as Adenovirus Vector Carrier, K. Kawasaki,S. Kida,Y. Eto,Y. Yoshioka,S. Nakagawa,K. Hojo,M. Maeda, JOURNAL OF PEPTIDE SCIENCE, JOHN WILEY & SONS LTD, Vol. 16, p. 138-138, 2010/09
  • ナノ含有食品の安全性確保および安全なナノ含有食品の開発に向けて:ナノ酸化チタンの形状と免疫系への影響, 吉岡靖雄,森重智弘,吉川友章,長野一也,阿部康弘,鎌田春彦,伊藤徳夫,角田慎一,向洋平,岡田直貴,中川晋作,堤康央, 日本食品衛生学会学術講演会講演要旨集, (公社)日本食品衛生学会, Vol. 100回, p. 91-91, 2010/09
  • ナノマテリアルの安全確保に向けたNano-Safety Science研究, 吉岡靖雄,吉川友章,堤 康央, 日本衛生学会誌, 2010/09
  • 安全なナノマテリアルの開発に向けた非晶質ナノシリカの粒子特性と起炎性の連関評価, 吉岡靖雄,森重智弘,稲倉裕,吉川友章,角田慎一,向洋平,岡田直貴,中川晋作,堤康央, 日本免疫毒性学会講演抄録集, Vol. 17th(CD-ROM), 2010/08
  • Identification and evaluation of novel breast cancer related biomarker proteins by antibody proteomics technology, K. Nagano,T. Yamashita,S. Imai,Y. Abe,T. Yoshikawa,Y. Yoshioka,H. Kamada,Y. Tsutsumi,S. Tsunoda, EJC SUPPLEMENTS, PERGAMON-ELSEVIER SCIENCE LTD, Vol. 8, No. 5, p. 53-53, 2010/06
  • Identification and evaluation of tumour lymphatic endothelial cell-specific proteins by antibody proteomics technology, S. Tsunoda,K. Nagano,T. Yamashita,S. Imai,Y. Abe,T. Yoshikawa,Y. Yoshioka,H. Kamada,Y. Tsutsumi, EJC SUPPLEMENTS, PERGAMON-ELSEVIER SCIENCE LTD, Vol. 8, No. 5, p. 64-65, 2010/06
  • 線虫C.elegansにおけるナノシリカの生体影響及び遺伝子発現変動解析, 井口 綾子,上田 清佳,内匠 正太,山元 涼子,吉 赫哲,吉岡 靖雄,堤 康央,冨永 伸明,有薗 幸司, The Journal of Toxicological Sciences, (一社)日本毒性学会, Vol. 35, No. Suppl., p. S114-S114, 2010/05
  • 新規腫瘍MRI造影剤としてのPEG化金SPIOの有用性評価, 松尾奈緒美,松尾奈緒美,向洋平,小島拓記,吉川舞,清野智史,山本孝夫,吉岡靖雄,岡田直貴,高島庄太夫,中川晋作, Drug Deliv Syst, 日本DDS学会, Vol. 25, No. 3, p. 282-282, 2010/05
  • 親水性ゲルパッチによる抗原の角質層透過促進機構に関する検討, 岡本英揚,松尾一彦,川合泰明,権英淑,神山文男,向洋平,吉岡靖雄,岡田直貴,中川晋作, Drug Delivery System, 日本DDS学会, Vol. 25, No. 3, p. 311-311, 2010/05
  • Immuno‐conjugate製剤における抗体の細胞内侵入活性と抗腫瘍効果の連関解析, 吉川舞,向洋平,堤康央,角田慎一,吉岡靖雄,岡田直貴,中川晋作, Drug Deliv Syst, 日本DDS学会, Vol. 25, No. 3, p. 298-298, 2010/05
  • T細胞受容体の新規ターゲティング分子への適用を目指した検討, 成松翔伍,吉岡靖雄,堤康央,向洋平,岡田直貴,中川晋作, Drug Deliv Syst, 日本DDS学会, Vol. 25, No. 3, p. 290-290, 2010/05
  • 破傷風・ジフテリア経皮ワクチン製剤のヒトにおける安全性・有効性の検証, 廣部祥子,松尾一彦,権英淑,神山文男,浅田秀夫,高矢雄介,向洋平,吉岡靖雄,岡田直貴,中川晋作, Drug Delivery System, 日本DDS学会, Vol. 25, No. 3, p. 311-311, 2010/05
  • 生分解性マイクロニードルの経皮ワクチンデバイスとしての特性, 横田やよい,松尾一彦,権英淑,神山文男,向洋平,吉岡靖雄,岡田直貴,中川晋作, Drug Delivery System, 日本DDS学会, Vol. 25, No. 3, p. 311-311, 2010/05
  • 多種多様な抗原に適用できる新規経皮ワクチン製剤の開発, 齋塲雄貴,松尾一彦,権英淑,神山文男,向洋平,吉岡靖雄,岡田直貴,中川晋作, Drug Delivery System, 日本DDS学会, Vol. 25, No. 3, p. 312-312, 2010/05
  • アルツハイマー病に対する治療効果を狙った経皮ワクチン療法の開発, 亀井数正,松尾一彦,川合泰明,権英淑,神山文男,向洋平,吉岡靖雄,岡田直貴,中川晋作, Drug Delivery System, 日本DDS学会, Vol. 25, No. 3, p. 312-312, 2010/05
  • マラリア撲滅に向けた新規経皮ワクチン製剤の開発, 松尾一彦,綾部有里香,権英叔,神山文男,堀井俊宏,向洋平,吉岡靖雄,岡田直貴,中川晋作, Drug Delivery System, 日本DDS学会, Vol. 25, No. 3, p. 312-312, 2010/05
  • Special session presented by the Study Group on Fibrous and Particulate Substances (SGFPS): Invited lecture: The safety scientific assessment of nanomaterials, Japanese journal of hygiene, Vol. 65, No. 2, p. 253-255, 2010/04
  • Immune‐conjugate製剤の開発に適う細胞内侵入抗体の効率的創製法の確立, 吉川舞,向洋平,堤康央,角田慎一,吉岡靖雄,岡田直貴,中川晋作, 薬剤学, (公社)日本薬剤学会, Vol. 70, No. Suppl., p. 104-104, 2010/04
  • T細胞受容体の新規ターゲティング分子への適用を目指した検討, 成松翔伍,吉岡靖雄,堤康央,向洋平,岡田直貴,中川晋作, 薬剤学, (公社)日本薬剤学会, Vol. 70, No. Suppl., p. 140-140, 2010/04
  • 「貼るワクチン」の開発 VII~生分解性マイクロニードルを用いたインフルエンザワクチンの開発~, 川端洋輝,松尾一彦,権英淑,神山文男,向洋平,吉岡靖雄,岡田直貴,中川晋作, 日本薬学会年会要旨集, Vol. 130年会, No. 4, p. 163-163, 2010/03
  • 「貼るワクチン」の開発 III~生分解性マイクロニードルによる経皮抗原デリバリーに関する検討~, 横田やよい,松尾一彦,権英淑,神山文男,向洋平,吉岡靖雄,岡田直貴,中川晋作, 日本薬学会年会要旨集, Vol. 130年会, No. 4, p. 163-163, 2010/03
  • 「貼るワクチン」の開発 V~生分解性マイクロニードルを用いた破傷風・ジフテリアワクチンの開発~, 廣部祥子,松尾一彦,権英淑,神山文男,向洋平,吉岡靖雄,岡田直貴,中川晋作, 日本薬学会年会要旨集, Vol. 130年会, No. 4, p. 163-163, 2010/03
  • 「貼るワクチン」の開発 I~親水性ゲルパッチによる抗原蛋白質の角質層透過に関する検討~, 岡本英揚,川合泰明,松尾一彦,権英淑,神山文男,向洋平,吉岡靖雄,岡田直貴,中川晋作, 日本薬学会年会要旨集, Vol. 130年会, No. 4, p. 162-162, 2010/03
  • 「貼るワクチン」の開発 IV~生分解性マイクロニードルによる可溶性抗原および粒子状抗原に対する免疫誘導~, 瀬戸正志,松尾一彦,権英淑,神山文男,向洋平,吉岡靖雄,岡田直貴,中川晋作, 日本薬学会年会要旨集, Vol. 130年会, No. 4, p. 163-163, 2010/03
  • 「貼るワクチン」の開発 II~親水性ゲルパッチを用いた経皮ワクチンの臨床研究~, 齊塲雄貴,松尾一彦,権英淑,神山文男,浅田秀夫,向洋平,吉岡靖雄,岡田直貴,中川晋作, 日本薬学会年会要旨集, Vol. 130年会, No. 4, p. 163-163, 2010/03
  • 「貼るワクチン」の開発 VI~生分解性マイクロニードルを用いたマラリアワクチンの開発~, 綾部有里香,松尾一彦,権英淑,神山文男,堀井俊宏,向洋平,吉岡靖雄,岡田直貴,中川晋作, 日本薬学会年会要旨集, Vol. 130年会, No. 4, p. 163-163, 2010/03
  • プロテオミクスによる非アルコール性脂肪性肝疾患(NAFLD/NASH)のバイオマーカー探索, 渡邊 貴信,長野 一也,山下 琢矢,岡村 賢孝,金崎 聡一郎,阿部 康弘,吉川 友章,吉岡 靖雄,鎌田 春彦,伊藤 徳夫,小泉 桂一,角田 慎一,堤 康央, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 130年会, No. 4, p. 313-313, 2010/03
  • Nano-Safety Science for Assuring the Safety of Nanomaterials, YOSHIOKA Yasuo,YOSHIKAWA Tomoaki,TSUTSUMI Yasuo, Nippon Eiseigaku Zasshi (Japanese Journal of Hygiene), The Japanese Society for Hygiene, Vol. 65(4):487-492, No. 4, p. 487-492, 2010
  • Creation of TNFR1-selective Antagonist and Its Therapeutic Effects, NOMURA Tetsuya,ABE Yasuhiro,YOSHIOKA Yasuo,NAKAGAWA Shinsaku,TSUNODA Shin-ichi,TSUTSUMI Yasuo, YAKUGAKU ZASSHI, The Pharmaceutical Society of Japan, Vol. 130, No. 1, p. 63-68, 2010
  • Inflammatory responses of nanosilica with different size and properties, YOSHIOKA Yasuo,MORISHIGE Tomohiro,TSUNODA Shin-ichi,MUKAI Yohei,OKADA Naoki,TSUTSUMI Yasuo,NAKAGAWA Shinsaku, Annual Meeting of the Japanese Society of Toxicology, The Japanese Society of Toxicology, Vol. 37, No. 0, p. 111-111, 2010
  • 化粧品ナノマテリアルの安全性評価の現状と技術的課題～安全なナノマテリアルの開発支援に向けて～, 吉川友章,吉岡靖雄,角田慎一,堤 康央, コスメティックステージ, 技術情報協会, Vol. Vol.4(4): 44-48, No. 4, p. 44-48, 2010
  • Creation of TNFR1-selective Antagonist and Its Therapeutic Effects, Tetsuya Nomura,Yasuhiro Abe,Yasuo Yoshioka,Shinsaku Nakagawa,Shin-ichi Tsunoda,Yasuo Tsutsumi, YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, PHARMACEUTICAL SOC JAPAN, Vol. 130, No. 1, p. 63-68, 2010/01
  • Application of Bioactive Mutant TNF Alpha to a Mucosal Vaccine Adjuvant, Hiroyuki Kayamuro,Yasuo Yoshioka,Yasuhiro Abe,Haruhiko Kamada,Shin-ichi Tsunoda,Yasuo Tsutsumi, YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, PHARMACEUTICAL SOC JAPAN, Vol. 130, No. 1, p. 55-61, 2010/01
  • Antibody‐drug conjugateの開発に適う細胞内侵入抗体の効率的探索法, 吉川舞,向洋平,吉岡靖雄,岡田直貴,堤康央,角田慎一,中川晋作, 次世代を担う若手ファーマ・バイオフォーラム講演要旨集, Vol. 8th, 2009/11/02
  • 生分解性マイクロニードルを応用した経皮ワクチンの開発, 松尾一彦,横田やよい,廣部祥子,権英淑,神山文男,向洋平,吉岡靖雄,岡田直貴,中川晋作, 次世代を担う若手ファーマ・バイオフォーラム講演要旨集, Vol. 8th, 2009/11/02
  • Cancer hazard of carbon nanotubes: Size/shape-dependent induction of DNA damage and inflammation, Kohei Yamashita,Yasuo Yoshioka,Hiroyuki Kayamuro,Tokuyuki Yoshida,Kazuma Higashisaka,Yasuhiro Abe,Tomoaki Yoshikawa,Norio Itoh,Shin-ichi Tsunoda,Yasuo Tsutsumi, CYTOKINE, ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, Vol. 48, No. 1-2, p. 55-55, 2009/10
  • ナノマテリアルの安全確保に向けて―1 ナノマテリアルの経皮吸収性・体内動態と急性毒性・肝毒性, 角田慎一,吉川友章,鍋師裕美,赤瀬貴憲,長野一也,阿部康弘,吉岡靖雄,今澤孝喜,向洋平,岡田直貴,中川晋作,堤康央, 日本食品衛生学会学術講演会講演要旨集, Vol. 98回, p. 91-91, 2009/10
  • ナノマテリアルの安全確保に向けて―4 ナノマテリアルの動態特性と免疫毒性, 吉岡靖雄,森重智弘,稲倉裕,吉田徳幸,藤村真穂,鍋師裕美,阿部康弘,長野一也,吉川友章,今澤孝喜,角田慎一,向洋平,岡田直貴,堤康央,中川晋作, 日本食品衛生学会学術講演会講演要旨集, Vol. 98回, p. 94-94, 2009/10
  • Urban aerosol directly stimulates antigen presentation cells in vitro and cause airway inflammation in vivo, Tokuyuki Yoshida,Yasuo Yoshioka,Hiroyuki Kayamuro,Kohei Yamashita,Kazuma Higashisaka,Ryosuke Nakanishi,Yasuhiro Abe,Yu-ichi Kawai,Tadanori Mayumi,Tadanori Yoshikawa,Norio Itoh,Shin-ichi Tsunoda,Yasuo Tsutsumi, TOXICOLOGY LETTERS, ELSEVIER IRELAND LTD, Vol. 189, p. S176-S177, 2009/09
  • Evaluation of size-dependent acute toxicity and toxicokinetics of amorphous nanosilicas, Hiromi Nabeshi,Tomoaki Yoshikawa,Keigo Matsuyama,Yasutaro Nakazato,Takayoshi Imazawa,Yasuo Yoshioka,Yasuhiro Abe,Yu-ichi Kawai,Tadanori Mayumi,Norio Ito,Shin-ichi Tsunoda,Yasuo Tsutsumi, TOXICOLOGY LETTERS, ELSEVIER IRELAND LTD, Vol. 189, p. S181-S182, 2009/09
  • Differential acute toxicity and toxicokinetics of amorphous nanosilicas: The role of surface physicochemical properties, Yasutaro Nakazato,Tomoaki Yoshikawa,Hiromi Nabeshi,Keigo Matsuyama,Takayoshi Imazawa,Yasuo Yoshioka,Yasuhiro Abe,Yu-ichi Kawai,Tadanori Mayumi,Norio Itoh,Shin-ichi Tsunoda,Yasuo Tsutsumi, TOXICOLOGY LETTERS, ELSEVIER IRELAND LTD, Vol. 189, p. S183-S183, 2009/09
  • Evaluation of size-dependent intracellular distribution and genotoxicity of amorphous nanosilicas in human keratinocytes, Keigo Matsuyama,Tomoaki Yoshikawa,Hiromi Nabeshi,Yasutaro Nakazato,Takayoshi Imazawa,Yasuo Yoshioka,Yasuhiro Abe,Yu-ichi Kawai,Tadanori Mayumi,Norio Itoh,Shin-ichi Tsunoda,Yasuo Tsutsumi, TOXICOLOGY LETTERS, ELSEVIER IRELAND LTD, Vol. 189, p. S183-S183, 2009/09
  • In vitro nanotoxicologic studies of silica-nanoparticles using dermal cell lines, Tomoaki Yoshikawa,Hiromi Nabeshi,Keigo Matsuyama,Yasutaro Nakazato,Takayoshi Imazawa,Yasuo Yoshioka,Yasuhiro Abe,Yu-ichi Kawai,Tadanori Mayumi,Norio Itoh,Shin-ichi Tsunoda,Yasuo Tsutsumi, TOXICOLOGY LETTERS, ELSEVIER IRELAND LTD, Vol. 189, p. S179-S180, 2009/09
  • Ligand independent assembly of purified soluble Magic Roundabout (Robo4), a tumour-specific endothelial marker, M. Yoshikawa,Y. Mukai,Y. Okada,Y. Yoshioka,S. Tsunoda,Y. Tsutsumi,N. Okada,A. William C,T. Doi,S. Nakagawa, EJC SUPPLEMENTS, PERGAMON-ELSEVIER SCIENCE LTD, Vol. 7, No. 2, p. 103-103, 2009/09
  • 新規香粧品素材として注目されるナノシリカの経皮リスクに関する基礎検討, 松尾一彦,免山智行,角田慎一,堤康央,向洋平,吉岡靖雄,岡田直貴,中川晋作, 日本香粧品学会誌, 日本香粧品学会, Vol. 33, No. 3, p. 218-219, 2009/09
  • ファージ表面提示法を駆使した活性増強型TNF変異体の創出とその特性, 鎌田春彦,阿部康弘,吉岡靖雄,野村鉄也,萱室裕之,向洋平,中川晋作,角田慎一,堤康央, 生化学, (公社)日本生化学会, Vol. 82回, p. 2P-404, 2009/09
  • 非晶質シリカの粒子特性と起炎性の連関評価, 吉岡靖雄,森重智弘,稲倉裕,田辺綾,堤康央,角田慎一,河合裕一,眞弓忠範,向洋平,岡田直貴,中川晋作, 日本免疫毒性学会講演抄録集, Vol. 16th, 2009/08/10
  • 特定細胞内へのドラッグデリバリーを目指した細胞内侵入抗体の効率的な創製法の確立(High-throughput screening method of Cell-internalizing monoclonal antibodies, potent anti-tumor drug delivery carriers), 吉川 舞,向 洋平,吉岡 靖雄,岡田 直貴,堤 康央,角田 慎一,中川 晋作, 日本癌学会総会記事, 日本癌学会, Vol. 68回, p. 283-283, 2009/08
  • 親水性ゲルパッチを用いた経皮免疫製剤のアジュバント併用時の有効性評価, 齋場雄貴,松尾一彦,石井裕美子,川合泰明,権英淑,神山文男,向洋平,吉岡靖雄,岡田直貴,中川晋作, Drug Deliv Syst, 日本DDS学会, Vol. 24, No. 3, p. 322-322, 2009/06
  • T細胞受容体を用いた新規ターゲティング分子の創製, 成松翔伍,吉岡靖雄,渡辺光,堤康央,向洋平,岡田直貴,中川晋作, Drug Deliv Syst, 日本DDS学会, Vol. 24, No. 3, p. 330-330, 2009/06
  • 自己免疫疾患に対する有効性および安全性の向上を目指したTNFR1指向性アンタゴニストの改変, 野村鉄也,阿部康弘,吉岡靖雄,萱室裕之,向洋平,中川晋作,角田慎一,堤康央, Drug Deliv Syst, 日本DDS学会, Vol. 24, No. 3, p. 360-360, 2009/06
  • 抑制性レセプターを回避し得るLIGHT変異体の創製とその機能評価, 稲倉裕,吉岡靖雄,森重智弘,堤康央,向洋平,岡田直貴,中川晋作, 日本蛋白質科学会年会プログラム・要旨集, Vol. 9th, 2009/04/24
  • TNFR1選択的阻害剤の開発を目指したTNFR1選択的変異体の創製とそのレセプター結合における構造‐活性相関研究, 向洋平,柴田寛子,中村照也,吉岡靖雄,阿部康弘,野村鉄也,谷合まどか,太田恒孝,池水信二,鎌田春彦,角田慎一,中川晋作,山縣ゆり子,堤康央, 日本蛋白質科学会年会プログラム・要旨集, Vol. 9th, 2009/04/24
  • T細胞受容体を用いた新規ターゲティング分子の創製, 成松翔伍,吉岡靖雄,渡辺光,堤康央,向洋平,岡田直貴,中川晋作, 日本蛋白質科学会年会プログラム・要旨集, Vol. 9th, 2009/04/24
  • TNFR1選択的阻害剤の開発を目指したTNFR1選択的変異体の創製とそのレセプター結合における構造‐活性相関研究, 向洋平,柴田寛子,中村照也,吉岡靖雄,阿部康弘,野村鉄也,谷合まどか,太田恒孝,池水信二,鎌田春彦,角田慎一,中川晋作,山縣ゆり子,堤康央, 日本蛋白質科学会年会プログラム・要旨集, Vol. 9th, 2009/04/24
  • 活性増強型リンフォトキシンαの機能解明, 渡辺光,吉岡靖雄,堤康央,向洋平,岡田直貴,中川晋作, 日本蛋白質科学会年会プログラム・要旨集, Vol. 9th, 2009/04/24
  • レセプター指向性を有するリンフォトキシンαの創製と特性評価, 吉岡靖雄,渡辺光,堤康央,AHMAD Shandar,長尾知生子,池水信二,水口賢司,向洋平,岡田直貴,中川晋作, 日本蛋白質科学会年会プログラム・要旨集, Vol. 9th, 2009/04/24
  • Antibody‐drug conjugate製剤の開発に適う細胞内侵入抗体の効率的創製法の確立, 吉川舞,向洋平,久保貴,吉岡靖雄,岡田直貴,堤康央,角田慎一,中川晋作, 薬剤学, (公社)日本薬剤学会, Vol. 69, No. Suppl., p. 131-131, 2009/04
  • 微細超常磁性酸化鉄粒子(USPIO)をコアとしたPEG化金磁性ナノ粒子の創製とそのMRI腫瘍造影剤としての有用性評価, 小島拓記,向洋平,森田将史,犬伏俊郎,山本孝夫,吉岡靖雄,岡田直貴,清野智史,中川晋作, 薬剤学, (公社)日本薬剤学会, Vol. 69, No. Suppl., p. 133-133, 2009/04
  • 新規素材として期待されるナノマテリアルの自然免疫攪乱作用に関する検討, 吉岡靖雄,田辺綾,森重智弘,姚醒蕾,渡辺光,室井正志,棚元憲一,堤康央,向洋平,岡田直貴,中川晋作, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 129年会, No. 3, p. 155-155, 2009/03
  • 各種酸化チタンの起炎性評価及びそのメカニズム解析, 森重智弘,吉岡靖雄,田辺綾,渡辺光,姚醒蕾,堤康央,向洋平,岡田直貴,中川晋作, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 129年会, No. 3, p. 180-180, 2009/03
  • TNFSF14/LIGHTによる効率的な腫瘍特異的免疫応答の惹起と抗腫瘍効果に関する検討, 稲倉裕,吉岡靖雄,森重智弘,田辺綾,渡辺光,姚醒蕾,堤康央,向洋平,岡田直貴,中川晋作, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 129年会, No. 3, p. 170-170, 2009/03
  • ナノシリカの皮膚透過性と経皮リスクに関する基礎検討, 松尾一彦,免山智行,角田慎一,堤康央,向洋平,吉岡靖雄,岡田直貴,中川晋作, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 129年会, No. 4, p. 286-286, 2009/03
  • 破傷風・ジフテリアに対する経皮免疫製剤の実用化に向けた基礎的検討, 川合泰明,松尾一彦,石井裕美子,齋塲雄貴,権英淑,神山文男,向洋平,吉岡靖雄,岡田直貴,中川晋作, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 129年会, No. 4, p. 165-165, 2009/03
  • I型TNF受容体選択的アンタゴニストの創出とその自己免疫疾患治療薬としての可能性, 野村鉄也,阿部康弘,吉岡靖雄,中川晋作,角田慎一,堤康央, 日本薬学会年会要旨集, Vol. 129年会, No. 1, p. 253-253, 2009/03
  • 遺伝子工学的手法を用いた神経幹細胞から膵β細胞への分化誘導, 林香織,金川尚子,向洋平,吉岡靖雄,水口裕之,岡田直貴,中川晋作, 再生医療, Vol. 8, 2009/02/05
  • Evaluation of depressive effect against innate immune response induced by noncrystalline nano silica, MORISHIGE Tomohiro,OKADA Naoki,NAKAGAWA Shin-saku,YOSHIOKA Yasuo,TANABE Aya,TSUTSUMI Yasuo,MUROI Masashi,TANAMOTO Ken-ichi,KAWAI Yuchi,MAYUMI Tadanori,MUKAI Yohei, Annual Meeting of the Japanese Society of Toxicology, The Japanese Society of Toxicology, Vol. 36, No. 0, p. 3009-3009, 2009
  • Evaluation and mechanistic analysis of the inflammation induced by various titanium dioxide, Inakura Hiroshi,Nakagawa Shinsaku,Yoshioka Yasuo,Morishige Tomohiro,Tanabe Aya,Tsutsumi Yasuo,Kawai Yuuithi,Mayumi Tadanori,Mukai Youhei,Okada Naoki, Annual Meeting of the Japanese Society of Toxicology, The Japanese Society of Toxicology, Vol. 36, No. 0, p. 3012-3012, 2009
  • Systematic evaluation between particle characteristics of silica and inflammatory responses, Yoshioka Yasuo,Morishige Tomohiro,Tanabe Aya,Tsutsumi Yasuo,Kawai Yuuichi,Mayumi Tadanori,Mukai Yohei,Okada Naoki,Nakagawa Shinsaku, Annual Meeting of the Japanese Society of Toxicology, The Japanese Society of Toxicology, Vol. 36, No. 0, p. 4112-4112, 2009
  • Development of PEGylated adenovirus vector for cancer gene therapy, Yusuke Eto,Yasuo Yoshioka,Ratima Asavatanabodee,Hiroyuki Mizuguchi,Yohei Mukai,Naoki Okada,Shinsaku Nakagawa, Yakugaku Zasshi, (公社)日本薬学会, Vol. 128, No. 12, p. 1733-1742, 2008/12
  • Evaluation of Biological Influence of Nano-materials using Toxicokinetic and Toxicoproteomic Approach, Tomoaki Yoshikawa,Hiromi Nabeshi,Yasuo Yoshioka, YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, PHARMACEUTICAL SOC JAPAN, Vol. 128, No. 12, p. 1715-1725, 2008/12
  • Development of PEGylated Adenovirus Vector for Cancer Gene Therapy, Yusuke Eto,Yasuo Yoshioka,Ratima Asavatanabodee,Hiroyuki Mizuguchi,Yohei Mukal,Shinsaku Nakagawa, YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, PHARMACEUTICAL SOC JAPAN, Vol. 128, No. 12, p. 1733-1742, 2008/12
  • ナノマテリアルの自然免疫活性化メカニズムの検討, 田辺綾,吉岡靖雄,森重智弘,角田慎一,堤康央,向洋平,岡田直貴,中川晋作, 日本バイオマテリアル学会シンポジウム予稿集, 日本バイオマテリアル学会, Vol. シンポジウム2008, p. 250-250, 2008/11
  • これからのアレルゲン研究 コチニール色素中の主要アレルゲンタンパク質の解析, 扇谷 陽子,穐山 浩,荒川 史博,酒井 信夫,吉岡 靖雄,山川 有子,池澤 善郎,手島 玲子, アレルギー, (一社)日本アレルギー学会, Vol. 57, No. 9-10, p. 1405-1405, 2008/10
  • Mutant TNF elicits Th2-type responses for enhanced mucosal immunity, Hiroyuki Kayamuro,Yasuo Yoshioka,Kazufumi Katayama,Haruhiko Kamada,Tetsuya Nomura,Yasuhiro Abe,Takachika Hiroi,Shin-ichi Tsunoda,Yasuo Tsutsumi, CYTOKINE, ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD, Vol. 43, No. 3, p. 309-309, 2008/09
  • 活性増強型リンフォトキシンαの創製とその特性評価(In vitro and in vivo antitumor effects of mutant lymphotoxin-αs with enhanced bioactivities), 渡辺 光,吉岡 靖雄,森重 智弘,角田 慎一,鎌田 春彦,堤 康央,向 洋平,岡田 直貴,中川 晋作, 日本癌学会総会記事, 日本癌学会, Vol. 67回, p. 314-314, 2008/09
  • 抗体プロテオミクスによる効率的な腫瘍バイオマーカー探索とバリデーション(Antibody-based proteomics for efficient discovery and validation of tumor biomarkers), 角田 慎一,長野 一也,吉川 友章,吉岡 靖雄,中川 晋作,阿部 康弘,鎌田 春彦,堤 康央, 日本癌学会総会記事, 日本癌学会, Vol. 67回, p. 343-343, 2008/09
  • 各種ナノマテリアルの自然免疫応答に及ぼす影響, 田辺綾,吉岡靖雄,森重智弘,角田慎一,堤康央,向洋平,岡田直貴,中川晋作, 日本免疫毒性学会講演抄録集, Vol. 15th, 2008/08/22
  • Development of PEGylated adenovirus vector with targeting ligand., Eto Y,Yoshioka Y,Mukai Y,Okada N,Nakagawa S, Int J Pharm., Vol. 354, p. 3-8, 2008/08
  • 金磁性ナノ粒子が可能とする遺伝子導入技術の確立, 小島拓記,吉川友章,亀井数正,清野智史,山本孝夫,吉岡靖雄,岡田直貴,向洋平,中川晋作, Drug Deliv Syst, Vol. 23, No. 3, 2008/06/06
  • アンタゴニスト活性を有するI型受容体指向性TNF変異体の評価:関節リウマチモデルに対する治療効果および安全性の検討, 野村鉄也,吉岡靖雄,柴田寛子,阿部康弘,蓑輪恭子,萱室裕之,萱室裕之,中川晋作,鎌田春彦,角田慎一,堤康央, Drug Deliv Syst, Vol. 23, No. 3, 2008/06/06
  • 腫瘍血管と癌細胞を共に傷害する遺伝子改変T細胞の癌養子免疫療法における有用性評価, 川合泰明,金川尚子,柳川達也,向洋平,吉岡靖雄,岡田直貴,中川晋作, Drug Deliv Syst, Vol. 23, No. 3, 2008/06/06
  • PEG修飾タンパクおよびPEG修飾アデノウイルス投与による抗PEG IgM誘導に関する検討, 清水太郎,名和田幸介,吉岡靖雄,石田竜弘,中川晋作,際田弘志, Drug Delivery System, Vol. 23, No. 3, 2008/06/06
  • 新規腫瘍MRI造影剤の開発を目指したPEG化金磁性ナノ粒子の創製, 亀井数正,向洋平,小島拓記,森田将史,犬伏俊郎,清野智史,山本孝夫,吉岡靖雄,岡田直貴,中川晋作, Drug Deliv Syst, Vol. 23, No. 3, 2008/06/06
  • ファージ表面提示法を用いた活性増強型リンフォトキシンαの創製とその特性評価, 渡辺光,吉岡靖雄,森重智弘,鎌田春彦,向洋平,角田慎一,堤康央,岡田直貴,中川晋作, 日本蛋白質科学会年会プログラム・要旨集, Vol. 8th, 2008/05/23
  • 遺伝子工学的手法を用いた高機能化細胞傷害性T細胞の創製とその癌養子免疫療法への応用, 金川尚子,柳川達也,向洋平,吉岡靖雄,岡田直貴,中川晋作, 遺伝子・デリバリー研究会シンポジウム要旨集, Vol. 8th, 2008/05/09
  • 転移癌遺伝子治療における全身投与型腫瘍標的化アデノウイルスベクターの有用性評価, 姚醒蕾,吉岡靖雄,衛藤佑介,森重智弘,水口裕之,向洋平,岡田直貴,中川晋作, 遺伝子・デリバリー研究会シンポジウム要旨集, Vol. 8th, 2008/05/09
  • 破傷風およびジフテリアに対する「貼るワクチン」の有効性評価, 石井裕美子,岡田直貴,坂本史子,権英淑,神山文男,向洋平,吉岡靖雄,中川晋作, 薬剤学, (公社)日本薬剤学会, Vol. 68, No. Suppl., p. 216-216, 2008/04
  • 各種細胞膜移行ペプチドにより修飾したアデノウイルスベクターの遺伝子導入特性評価, ASAVATANABODEE Ratima,吉岡靖雄,衛藤佑介,喜田進也,前田光子,水口裕之,向洋平,岡田直貴,川崎紘一,中川晋作, 日本薬学会年会要旨集, Vol. 128th, No. 4, 2008/03/05
  • 標的指向能を有するバイオコンジュゲート化アデノウイルスベクターの開発, 衛藤佑介,吉岡靖雄,ASAVATANABODEE Ratima,水口裕之,向洋平,岡田直貴,中川晋作, 日本薬学会年会要旨集, Vol. 128th, No. 1, 2008/03/05
  • 香粧品材料としてのナノマテリアルの経皮リスクに関する基礎検討, 亀井数正,向洋平,小島拓記,吉川舞,角田慎一,堤康央,吉岡靖雄,岡田直貴,中川晋作, 日本薬学会年会要旨集, Vol. 128th, No. 4, 2008/03/05
  • 効率的な遺伝子細胞内送達のためのアデノウイルスベクター修飾用細胞膜透過性キャリアーペプチドの合成, 喜田進也,衛藤佑介,ASAVATANABODEE Ratima,前田光子,吉岡靖雄,中川晋作,北條恵子,津田裕子,眞弓忠範,川崎紘一, 日本薬学会年会要旨集, Vol. 128th, No. 2, 2008/03/05
  • Cell-Penetrating Peptides as Adenovirus Vector Carrier, KIDA Shinya,ETO Yusuke,ASAVATANABODEE Ratima,MAEDA Mitsuko,YOSHIOKA Yasuo,NAKAGAWA Shinsaku,HOJO Keiko,TSUDA Yuko,MAYUMI Tadanori,KAWASAKI Koichi, Vol. 2007, p. 337-340, 2008/03/01
  • アンタゴニスト活性を有するI型受容体指向性TNF変異体の評価(1):関節リウマチモデルに対する治療効果の検討, 野村鉄也,吉岡靖雄,柴田寛子,阿部康弘,蓑輪恭子,萱室裕之,中川晋作,山本昌,鎌田春彦,角田慎一,堤康央, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 128年会, No. 3, p. 9-9, 2008/03
  • 腫瘍血管傷害性T細胞の創製とその養子免疫療法への応用, 金川尚子,柳川達也,井口香菜子,向洋平,吉岡靖雄,岡田直貴,中川晋作, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 128年会, No. 4, p. 99-99, 2008/03
  • Comparative study on transduction and toxicity of protein transduction domains, T. Sugita,T. Yoshikawa,Y. Mukai,N. Yamanada,S. Imai,K. Nagano,Y. Yoshida,H. Shibata,Y. Yoshioka,S. Nakagawa,H. Kamada,S-i Tsunoda,Y. Tsutsumi, BRITISH JOURNAL OF PHARMACOLOGY, NATURE PUBLISHING GROUP, Vol. 153, No. 6, p. 1143-1152, 2008/03
  • 神経幹細胞に対する各種ウイルスベクターの遺伝子導入特性の比較, 林香織,金川尚子,川合泰明,向洋平,吉岡靖雄,岡田直貴,中川晋作, 再生医療, Vol. 7, 2008/02/22
  • コチニール色素中の主要アレルゲンタンパク質のcDNAクローニング, 穐山浩,扇谷陽子,荒川史博,伊藤澄夫,酒井信夫,吉岡靖雄,吉岡靖雄,林芳樹,山川有子,山川有子,池澤善郎,手島玲子, 日本食品化学学会総会・学術大会講演要旨集, Vol. 14th, 2008
  • P-060 / O-06 Basic examination of carbon nanotube genotoxicity(Poster Session), Yamashita Kohei,Yoshioka Yasuo,Kayamuro Hiroyuki,Yoshida Tokuyuki,Higashisaka Kazuma,Nakanishi Ryosuke,Abe Yasuhiro,Kamada Haruhiko,Itoh Norio,Tsunoda Shin-ichi,Tsutsumi Yasuo, No. 37, p. 136-136, 2008
  • P-130 Basic examination of immunotoxicity of urban aerosols(Poster Session), Yoshida Tokuyuki,Yoshioka Yasuo,Kayamuro Hiroyuki,Yamashita Kouhei,Higashisaka Kazuma,Nakanishi Ryousuke,Abe Yasuhiro,Kamada Haruhiko,Itoh Norio,Tsunoda Shin-ichi,Tsutsumi Yasuo, No. 37, p. 171-171, 2008
  • ナノシリカの自然免疫応答に及ぼす影響, 吉岡靖雄,田辺綾,堤康央,向洋平,岡田直貴,中川晋作, 生化学, 2008
  • T細胞受容体を用いた新規ターゲティング分子の創製に関する基礎的検討, 成松翔伍,吉岡靖雄,堤康央,向洋平,岡田直貴,中川晋作, 生化学, 2008
  • ナノマテリアルのオートファジー誘導に関する検討, 田辺綾,吉岡靖雄,堤康央,向洋平,岡田直貴,中川晋作, 生化学, 2008
  • Creation of receptor-selective TNFs with agonistic activity, Shibata H,Kamada H,Yoshioka Y,Ohkawa A,Minowa K,Mukai Y,Abe Y,Taniai M,Nomura T,Kayamuro H,Nabeshi H,Sugita T,Imai S,Nagano K,Yoshikawa T,Fujita T,Nakagawa S,Yamamoto A,Ohta T,Hayakawa T,Mayumi T,Vandeenabeele P,Aggarwal BB,Tsunoda S,Tsutsumi Y, J. Biol. Chem., Vol. 283, No. 2, p. 998-1007, 2008
  • 医薬品・香粧品におけるナノマテリアルの安全性評価, 吉岡靖雄,吉川友章,角田慎一, Pharma VISION NEWS, Vol. 第12号: 14-18, 2008
  • 癌遺伝子治療の最適化を目指した高機能化アデノウイルスベクターの創製, 吉岡靖雄,向洋平,水口裕之,岡田直貴,中川晋作, 日本学術会議材料工学連合講演会講演論文集, Vol. 51st, 2007/11/27
  • 標的指向能を付与したバイオコンジュゲート化アデノウイルスベクターの創製, 衛藤佑介,吉岡靖雄,ASAVATANABODEE Ratima,水口裕之,向洋平,岡田直貴,中川晋作, 日本バイオマテリアル学会大会予稿集, 日本バイオマテリアル学会, Vol. 29回, p. 132-132, 2007/11
  • Tatペプチド修飾アデノウイルスベクターの構築と遺伝子導入特性評価, 吉岡靖雄,衛藤佑介,喜田進也,前田光子,向洋平,川崎紘一,岡田直貴,中川晋作, 日本血栓止血学会誌, (一社)日本血栓止血学会, Vol. 18, No. 5, p. 474-474, 2007/10
  • Telomeraseを標的とした樹状細胞療法の有効性、汎用性および安全性の評価(Investigation of efficacy, versatility, and safety of dendritic cell-based cancer immunotherapy targeting telomerase), 金川 尚子,岡田 直貴,柳川 達也,向 洋平,吉岡 靖雄,中川 晋作, 日本癌学会総会記事, 日本癌学会, Vol. 66回, p. 160-160, 2007/08
  • 抗原送達キャリアーとしてγ-PGAナノ粒子を用いた経鼻投与型癌ワクチンの開発(Development of nasal administration-type cancer vaccine using γ-PGA nanoparticle as an antigen delivery carrier), 松尾 一彦,松尾 圭祐,赤木 隆美,明石 満,向 洋平,吉岡 靖雄,岡田 直貴,中川 晋作, 日本癌学会総会記事, 日本癌学会, Vol. 66回, p. 425-425, 2007/08
  • 腫瘍血管を標的とする養子免疫療法の構築に向けた抗flk1 scFv発現CTLの創製と機能解析(Generation and functional analysis of CTLs expressing anti-flk1 scFv for tumor vessel-targeting adoptive immunotherapy), 柳川 達也,岡田 直貴,金川 尚子,向 洋平,吉岡 靖雄,中川 晋作, 日本癌学会総会記事, 日本癌学会, Vol. 66回, p. 426-426, 2007/08
  • Creation of TNF receptor1-selective mutant TNF using phage display system, Kyoko Minowa,Yoshioka Yasuo,Yasuhiro Abe,Tetsuya Nomura,Hiromi Nabeshi,Hiroyuki Kayamuro,Hiroko Shibata,Takuya Fujita,Akira Yamamoto,Shin-Ichi Tsunoda,Haruhiko Kamada,Yasuo Tsutsumi, CYTOKINE, ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD, Vol. 39, No. 1, p. 28-28, 2007/07
  • 抗原内包γ‐PGAナノ粒子を用いた経鼻投与型癌ワクチンの開発, 松尾一彦,小泉勇人,松尾圭祐,赤木隆美,明石満,藤田卓也,山本昌,向洋平,吉岡靖雄,岡田直貴,中川晋作, 薬剤学, (公社)日本薬剤学会, Vol. 67, No. Supplement, p. 373-373, 2007/05/10
  • 金磁性ナノ粒子を応用した新規遺伝子導入法の確立と特性評価, 亀井数正,吉川友章,松尾圭祐,向洋平,吉岡靖雄,吉岡靖雄,清野智史,山本孝夫,岡田直貴,中川晋作, 薬剤学, (公社)日本薬剤学会, Vol. 67, No. Supplement, p. 312-312, 2007/05/10
  • 癌免疫療法の有効性向上を目指した免疫細胞の体内動態制御技術の開発, 金川尚子,柳川達也,畑中豊,橋詰薫,向洋平,吉岡靖雄,岡田直貴,中川晋作, 薬剤学, (公社)日本薬剤学会, Vol. 67, No. Supplement, p. 371-371, 2007/05/10
  • ケモカインシステムを応用したCTLの体内動態制御とその癌養子免疫養法における有用性, 柳川達也,金川尚子,本村吉章,向洋平,吉岡靖雄,岡田直貴,中川晋作, 薬剤学, Vol. 67, No. Supplement, p. 294-294, 2007/05/10
  • 各種両親媒化高分子を素材とするナノ粒子のワクチンキャリアー機能に関する比較検討, 吉永知世,松尾圭祐,吉川友章,赤木隆美,明石満,向洋平,吉岡靖雄,岡田直貴,中川晋作, Drug Delivery System, 日本DDS学会, Vol. 22, No. 3, p. 345-345, 2007/05
  • LIGHT発現樹状細胞の定着腫瘍に対する抗腫瘍効果とその作用機序, 高橋正也,金川尚子,後藤美千代,柳川達也,水口裕之,向洋平,吉岡靖雄,岡田直貴,中川晋作, Drug Deliv Syst, 日本DDS学会, Vol. 22, No. 3, p. 344-344, 2007/05
  • 抗腫瘍活性に優れたTNFレセプター指向性変異体の創製, 野村鉄也,柴田寛子,阿部康弘,蓑輪恭子,鍋師裕美,中川晋作,吉岡靖雄,角田慎一,鎌田春彦,堤康央, Drug Deliv Syst, 日本DDS学会, Vol. 22, No. 3, p. 317-317, 2007/05
  • γ‐PGAナノ粒子を抗原送達キャリアーとして用いた樹状細胞免疫療法の有効性評価, 石井裕美子,松尾圭祐,吉川友章,赤木隆美,明石満,向洋平,吉岡靖雄,岡田直貴,中川晋作, Drug Deliv Syst, 日本DDS学会, Vol. 22, No. 3, p. 345-345, 2007/05
  • 腫瘍での遺伝子発現増強と肝臓への集積性・遺伝子発現抑制を充たし得るPEG修飾アデノウイルスベクターの創製, 森重智弘,吉岡靖雄,衛藤佑介,倉知慎之輔,姚醒蕾,水口裕之,向洋平,岡田直貴,中川晋作, Drug Deliv Syst, 日本DDS学会, Vol. 22, No. 3, p. 369-369, 2007/05
  • 幹細胞分化制御技術の開発に向けた神経幹細胞への効率的な遺伝子導入法の探索, 林香織,金川尚子,柳川達也,向洋平,吉岡靖雄,岡田直貴,中川晋作, Drug Deliv Syst, 日本DDS学会, Vol. 22, No. 3, p. 369-369, 2007/05
  • TNFレセプターの機能解析を目指したTNFR2指向性変異体の作製, 野村鉄也,柴田寛子,阿部康弘,蓑輪恭子,鍋師裕美,吉岡靖雄,中川晋作,鎌田春彦,角田慎一,堤康央, 日本薬学会年会要旨集, Vol. 127th, No. 2, 2007/03/05
  • TNFR1指向性変異体を目指した新規ファージライブラリの作製, 鎌田春彦,柴田寛子,阿部康弘,野村鉄也,鍋師裕美,蓑輪恭子,中川晋作,吉岡靖雄,角田慎一,堤康央, 日本薬学会年会要旨集, Vol. 127th, No. 2, 2007/03/05
  • アンタゴニスト活性を有したTNF変異体の創製に関する基礎的検討―1, 柴田寛子,蓑輪恭子,阿部康弘,野村鉄也,鍋師裕美,吉岡靖雄,中川晋作,鎌田春彦,角田慎一,堤康央, 日本薬学会年会要旨集, Vol. 127th, No. 2, 2007/03/05
  • 特異的結合能を有する構造変異体のスクリーニング条件の最適化, 阿部康弘,柴田寛子,野村鉄也,鍋師裕美,蓑輪恭子,鎌田春彦,中川晋作,吉岡靖雄,角田慎一,堤康央, 日本薬学会年会要旨集, Vol. 127th, No. 2, 2007/03/05
  • 抗原内包γ‐PGAナノ粒子の免疫誘導機構と安全性に関する検討, 松尾圭祐,吉川友章,萱室裕之,松尾一彦,赤木隆美,明石満,向洋平,吉岡靖雄,岡田直貴,中川晋作, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 127年会, No. 3, p. 86-86, 2007/03
  • 金磁性ナノ粒子を応用したアデノウイルスベクターの遺伝子導入スペクトラムの拡大, 亀井数正,吉川友章,松尾圭祐,向洋平,吉岡靖雄,清野智史,山本孝夫,岡田直貴,中川晋作, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 127年会, No. 3, p. 88-88, 2007/03
  • 抗腫瘍活性・リンパ組織形成能に優れた機能化LIGHT変異体創製に関する基礎的検討, 森重智弘,吉岡靖雄,渡辺光,鎌田春彦,向洋平,角田慎一,岡田直貴,堤康央,中川晋作, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 127年会, No. 3, p. 130-130, 2007/03
  • 人工リンパ組織構築を目指したリジン欠損リンフォトキシン変異体創製に関する基礎的検討, 渡辺光,吉岡靖雄,森重智弘,鎌田春彦,向洋平,角田慎一,岡田直貴,堤康央,中川晋作, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 127年会, No. 3, p. 131-131, 2007/03
  • TNF関連分子発現樹状細胞を用いた定着腫瘍に対する新規免疫療法の開発, 後藤美千代,金川尚子,岡田裕香,向洋平,吉岡靖雄,岡田直貴,中川晋作, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 127年会, No. 3, p. 230-230, 2007/03
  • 広範な感染域を有するTatペプチド修飾アデノウイルスベクターの作製と遺伝子導入特性評価, ASAVATANABODEE Ratima,吉岡靖雄,衛藤佑介,喜田進也,前田光子,水口裕之,向洋平,岡田直貴,川崎紘一,中川晋作, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 127年会, No. 3, p. 160-160, 2007/03
  • 腫瘍特異的プロモーター搭載アデノウイルスベクターを用いた自殺遺伝子治療, 姚醒蕾,吉岡靖雄,衛藤佑介,水口裕之,岡田裕香,向洋平,岡田直貴,中川晋作, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 127年会, No. 3, p. 160-160, 2007/03
  • ケモカイン‐ケモカインレセプター連関を利用した癌養子免疫療法の有効性改善, 柳川達也,金川尚子,本村吉章,向洋平,吉岡靖雄,岡田直貴,中川晋作, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 127年会, No. 3, p. 230-230, 2007/03
  • Adenovirus Vector Carrierとしての細胞膜透過性ペプチド, 喜田進也,前田光子,北條恵子,衛藤佑介,森重智弘,渡辺光,ASAVATANABODEE Ratima,吉岡靖雄,水口裕之,真弓忠範,中川晋作,川崎紘一, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 127年会, No. 4, p. 116-116, 2007/03
  • アデノウイルスベクター内封PEG化リポソームの創製および精製法の確立, 衛藤佑介,吉岡靖雄,姚醒蕾,吉川友章,向洋平,鈴木亮,宇都口直樹,岡田直貴,丸山一雄,中川晋作, 日本薬学会年会要旨集, Vol. 127年会, No. 3, p. 160-160, 2007/03
  • コチニール色素のアレルゲン蛋白質の解析と夾雑蛋白質分析法の検討 第2報, 荒川史博,津嶋容子,大西邦義,伊藤澄夫,穐山浩,吉岡靖雄,米谷民雄, 日本食品化学学会総会・学術大会講演要旨集, Vol. 13th, 2007
  • Creation of TNFR2-selective mutants using phage display technique, Abe Yasuhiro,Tsutsumi Yasuo,Nomura Tetsuya,Nabeshi Hiromi,Kayamuro Kyoko,Minowa Kyoko,Kamada Haruhiko,Nakagawa Shinsaku,Yoshioka Yasuo,Tsunoda Shin-ichi, Abstracts for Annual Meeting of Japanese Proteomics Society, Japanese Proteomics Society (Japan Human Proteome Organisation), Vol. 2007, No. 0, p. 153-153, 2007
  • 全身投与による癌遺伝子治療の最適化を目指した高分子バイオコンジュゲート化アデノウイルスベクターの創製, 衛藤佑介,吉岡靖雄,森重智弘,姚醒蕾,倉知慎之輔,水口裕之,堤康央,向洋平,岡田直貴,中川晋作, 遺伝子・デリバリー研究会シンポジウム要旨集, Vol. 7th, 2007
  • 金磁性ナノ粒子を応用した新規遺伝子導入法の特性評価, 亀井数正,小島拓記,向洋平,吉川友章,吉岡靖雄,清野智史,山本孝夫,岡田直貴,中川晋作, 生化学, 2007
  • γ‐PGAナノ粒子の抗原送達キャリアー特性とその癌免疫療法への応用, 松尾圭祐,吉川友章,松尾一彦,石井裕美子,吉永知世,赤木隆美,明石満,向洋平,吉岡靖雄,岡田直貴,中川晋作, 遺伝子・デリバリー研究会シンポジウム要旨集, Vol. 7th, 2007
  • 血管新生に関わるRobo4蛋白質の発現と精製, 吉川舞,向洋平,岡田欣晃,土井健史,吉岡靖雄,岡田直貴,堤康央,角田慎一,中川晋作, 生化学, 2007
  • Systemic Administration of PEGylated Adenovirus Vector Enhances Vector Accumulation and Gene Expression in Tumors and Improves Anti-tumor Effects in Cytokine Gene Therapy, Gao J.Q,Eto Y,Yoshioka Y,Sekiguchi F,Kurachi S,Morishige T,Yao X,Watanabe H,Asavatanabodee R,Sakurai F,Mizuguchi H,Okada Y,Mukai Y,Tsutsumi Y,Mayumi T,Okada N,Nakagawa S, J. Control. Release, Vol. 122, No. 1, p. 102-110, 2007
  • 癌遺伝子治療の最適化を目指したTatペプチド修飾アデノウイルスベクターの作製と遺伝子導入特性評価, 渡辺光,衛藤佑介,森重智弘,喜田進也,前田光子,水口裕之,吉岡靖雄,岡田直貴,中川晋作, 日本癌学会学術総会記事, Vol. 65th, 2006/08/28
  • PEGylationと腫瘍特異的プロモーターの併用による腫瘍標的化アデノウイルスベクターの最適化, 森重智弘,衛藤佑介,倉知慎之介,渡辺光,岡田裕香,水口裕之,吉岡靖雄,岡田直貴,中川晋作, 日本癌学会学術総会記事, Vol. 65th, 2006/08/28
  • Tatペプチド修飾アデノウイルスベクターの開発と遺伝子導入特性に関する検討, 渡辺光,衛藤佑介,森重智弘,姚醒蕾,吉岡靖雄,喜田進也,前田光子,川崎紘一,水口裕之,岡田直貴,中川晋作, Drug Deliv Syst, 日本DDS学会, Vol. 21, No. 3, p. 308-308, 2006/06
  • ヒトプラスミノーゲンクリングル5関連ペプチドの合成, 前田光子,望月麻友美,武林久瑠美,吉岡靖雄,喜田進也,北条恵子,堤康央,中川晋作,真弓忠範,野水基義,川崎紘一, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 126年会, No. 3, p. 45-45, 2006/03
  • Approach to life science research from the view point of foods, YOSHIOKA Yasuo, Vol. 20, No. 6, p. 678-679, 2005/11/10
  • スギヒラタケ中の成分分析について, 穐山浩,天倉吉章,近藤一成,吉岡靖雄,米谷民雄,酒井信夫,戸井田敏彦, 日本食品衛生学会学術講演会講演要旨集, (公社)日本食品衛生学会, Vol. 90回, p. 27-27, 2005/10
  • Phage display and PEGylation of therapeutic proteins., Mukai Y,Yoshioka Y,Tsutsumi Y, Comb Chem High Throughput Screen., 2005/05
  • Research on analysis of harmful ingredients in Pleurocybella porrigens. Analysis of the mushroom ingredients., 穐山浩,天倉吉章,近藤一成,吉岡靖雄,小川温子,吉田奈央,笠原義正,戸井田敏彦,酒井信夫, スギヒラタケ中の有害成分の分析に関する研究 平成16年度 総括・分担研究報告書, 2005
  • Bioconjugation of proteins with polymeric modifiers for improvement of their therapeutic efficacy., Mukai Y,Tsutsumi Y,Yoshioka Y,Mayumi T, Current Topics in Peptide & Protein Reserch, 2004/08
  • Creation of Functional Muteins Using Phage Libraries for Pharmacoproteomic-based Drug Discovery and Development of DDS, YOSHIOKA Yasuo, YAKUGAKU ZASSHI, The Pharmaceutical Society of Japan, Vol. 124, No. 8, p. 531-539, 2004/08
  • Recent progress on tumor missile therapy and tumor vascular targeting therapy as a new approach, Yasuo Yoshioka,Yasuo Tsutsumi,Shinsaku Nakagawa,Tadanori Mayumi, Current Vascular Pharmacology, Vol. 2, No. 3, p. 259-270, 2004/07
  • プロテオーム創薬にかなう機能性人工蛋白質の迅速創出とそのバイオコンジュゲーションへの展開, 柴田 寛子,阿部 康弘,岡本 貴行,向 洋平,川村 真紀,大和 友子,中川 晋作,吉岡 靖雄,堤 康央,真弓 忠範, Drug Delivery System, 日本DDS学会, Vol. 19, No. 3, p. 272-272, 2004/05
  • ファージ表面提示法を駆使した部位特異的バイオコンジュゲーションの最適化, 阿部 康弘,柴田 寛子,岡本 貴行,向 洋平,川村 真紀,大和 友子,中川 晋作,吉岡 靖雄,堤 康央,真弓 忠範, Drug Delivery System, 日本DDS学会, Vol. 19, No. 3, p. 292-292, 2004/05
  • 新規腎ターゲティングキャリアーの腎疾患治療への応用, 柴田 寛子,吉岡 靖雄,向 洋平,阿部 康弘,岡本 貴行,清水 智絵,川村 真紀,鎌田 春彦,堤 康央,中川 晋作,真弓 忠範, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 124年会, No. 4, p. 114-114, 2004/03
  • 蛋白療法の最適化に向けた腎ターゲティングキャリアの開発, 向 洋平,吉岡 靖雄,柴田 寛子,阿部 康弘,岡本 貴行,清水 智絵,川村 真紀,鎌田 春彦,堤 康央,中川 晋作,真弓 忠範, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 124年会, No. 4, p. 114-114, 2004/03
  • 細胞内移行ペプチドを利用した細胞内薬物デリバリーに関する基礎的検討, 岡本貴行,川村真紀,吉岡靖雄,柴田寛子,清水智絵,向洋平,阿部康弘,堤康央,中川晋作, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 124年会, No. 4, p. 114-114, 2004/03
  • 医薬価値に優れた新規機能性ペプチドの網羅的探索システムの構築, 川村真紀,岡本貴行,吉岡靖雄,柴田寛子,清水智絵,向洋平,阿部康弘,堤康央,中川晋作, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 124年会, No. 4, p. 114-114, 2004/03
  • 食物アレルゲン経口感作におけるリンゴプロシアニジンの抑制効果, 穐山浩,佐藤雄嗣,渡辺敬浩,浜野恵,吉岡靖雄,庄司俊彦,神田智正,山田潔,戸塚護, 日本免疫学会総会・学術集会記録, Vol. 34, p. 117-117, 2004
  • 医薬価値に優れた機能性人工蛋白質を迅速創製可能な創薬戦略の確立に向けて, 吉岡靖雄,堤康央,中川晋作,真弓忠範, 日本癌学会総会記事, 日本癌学会, Vol. 62回, p. 159-159, 2003/08
  • 医薬価値に優れた機能性人工タンパク質の網羅的かつ迅速同定システムとプロテオーム創薬への展開, 堤康央,吉岡靖雄,真弓忠範, 細胞工学, 2003/08
  • 抗TNF療法の最適化に向けた1本鎖抗体の部位特異的バイオコンジュゲーションに関する基礎的検討, 川村真紀,岡本貴行,吉岡靖雄,向洋平,清水智絵,柴田寛子,堤康央,中川晋作,真弓忠範, Drug Deliv Syst, 日本DDS学会, Vol. 18, No. 3, p. 296-296, 2003/05
  • 癌ミサイル療法の最適化に向けたImmunotoxinの部位特異的バイオコンジュゲーションに関する検討, 向洋平,吉岡靖雄,岡本貴行,吉川友章,柴田寛子,清水智絵,川村真紀,中川晋作,真弓忠範, Drug Deliv Syst, 日本DDS学会, Vol. 18, No. 3, p. 265-265, 2003/05
  • 目的とする生理活性を完全に保持した機能性変異蛋白質の迅速構築とそのDDSへの応用, 吉岡 靖雄,堤 康央,山本 陽子,小林 恭子,柴田 寛子,岡本 貴行,吉川 友章,清水 はな,清水 智絵,向 洋平,川村 真紀,中川 晋作,真弓 忠範, 薬剤学: 生命とくすり, (公社)日本薬剤学会, Vol. 63, No. Suppl., p. 118-118, 2003/03/05
  • ファージ表面提示法を駆使した部位特異的バイオコンジュゲーションの最適化, 柴田寛子,吉岡靖雄,小林恭子,岡本貴行,堤康央,中川晋作,真弓忠範, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 123年会, No. 4, p. 86-86, 2003/03
  • 抗TNF‐alpha療法の最適化に向けて:TNF‐alphaに対する1本鎖抗体の作製とその特性評価, 岡本貴行,吉岡靖雄,向洋平,川村真紀,堤康央,中川晋作,真弓忠範, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 123年会, No. 4, p. 86-86, 2003/03
  • Phage display systemを利用した機能性1本鎖抗体の創出に関する基礎的検討, 向洋平,吉岡靖雄,岡本貴行,川村真紀,堤康央,中川晋作,真弓忠範, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 123年会, No. 4, p. 87-87, 2003/03
  • 医薬価値に優れた機能性人工蛋白質の設計戦略確立に向けて 1, 清水智絵,吉岡靖雄,小林恭子,吉川友章,岡本貴行,柴田寛子,堤康央,中川晋作,真弓忠範, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 123年会, No. 4, p. 87-87, 2003/03
  • 医薬価値に優れた機能性人工蛋白質の設計戦略確立に向けて 2, 吉川友章,吉岡靖雄,小林恭子,岡本貴行,柴田寛子,清水智絵,堤康央,中川晋作,真弓忠範, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 123年会, No. 4, p. 87-87, 2003/03
  • 部位特異的バイオコンジュゲーション・システムの構築 リジン欠損TNF‐α変異体の作製とその評価, 吉岡靖雄,堤康央,宮本陽子,中川晋作,真弓忠範, 日本癌学会総会記事, Vol. 61st, 2002/08/25
  • Cytomedical therapy for insulinopenic diabetes using microencapsulated pancreatic beta cell lines, R Suzuki,N Okada,H Miyamoto,T Yoshioka,K Sakamoto,H Oka,Y Tsutsumi,S Nakagawa,J Miyazaki,T Mayumi, LIFE SCIENCES, PERGAMON-ELSEVIER SCIENCE LTD, Vol. 71, No. 15, p. 1717-1729, 2002/08
  • ファージ抗体ライブラリによるモノクローナル抗体の網羅的迅速単離とその抗体療法の最適化に関する基礎的検討, 岡本貴行,吉岡靖雄,堤康央,向洋平,中川晋作,真弓忠範, Drug Deliv Syst, 日本DDS学会, Vol. 17, No. 3, p. 281-281, 2002/05
  • g8p提示型ファージペプチドライブラリの構築及び機能評価, 吉川友章,山本陽子,形山和史,吉岡靖雄,堤康央,中川晋作,真弓忠範, Drug Deliv Syst, 日本DDS学会, Vol. 17, No. 3, p. 282-282, 2002/05
  • 部位特異的バイオコンジュゲーション・システムの構築 リジン欠損TNF-α変異体の作製とその評価, 吉岡 靖雄,堤 康央,山本 陽子,西端 俊秀,小林 恭子,岡本 貴行,吉川 友章,清水 智絵,向 洋平,中川 晋作, Drug Delivery System, 日本DDS学会, Vol. 17, No. 3, p. 255-255, 2002/05
  • ナイーブ一本鎖抗体提示phage libraryの構築および特異的抗体単離に関する検討 (その1) phage libraryの作製, 吉岡靖雄,岡本貴行,向洋平,堤康央,中川晋作,真弓忠範, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 122年会, No. 4, p. 83-83, 2002/03
  • アデノウイルスファイバー領域を提示したファージの構築とそのペプチドライブラリ化, 吉川友章,山本陽子,形山和史,吉岡靖雄,水口裕之,早川尭夫,堤康央,中川晋作,真弓忠範, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 122年会, No. 4, p. 80-80, 2002/03
  • ナイーブ一本鎖抗体提示phage libraryの構築および特異的抗体単離に関する検討 (その2) 特異的抗体単離に関する検討, 岡本貴行,吉岡靖雄,向洋平,堤康央,中川晋作,真弓忠範, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 122年会, No. 4, p. 83-83, 2002/03
  • Construction and evaluation of phage-displayed naive antibody libraries derived from human, mouse and rabbit, 29th Annual Meeting of the Controlled Relearse Society, 2002
  • 細胞性製剤への抗補体作用付与による液性免疫隔離に関する基礎的検討, 岡本 貴行,吉岡 靖雄,鈴木 亮,岡田 直貴,北野 悦子,北村 肇,岡田 秀親,堤 康央,中川 晋作,真弓 忠範, Drug Delivery System, 日本DDS学会, Vol. 16, No. 4, p. 337-337, 2001/07
  • 液性免疫隔離能を有する細胞性製剤の設計, 吉岡靖雄,鈴木亮,岡本貴行,岡田直貴,北野悦子,北村肇,堤康央,中川晋作,真弓忠範, 薬剤学, Vol. 61, No. Supplement, p. 110-110, 2001/03/05
  • 体液性免疫隔離能を付与した細胞性製剤の開発, 鈴木亮,吉岡靖雄,岡本貴行,岡田直貴,宮崎純一,堤康央,中川晋作,真弓忠範, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 121年会, No. 3, p. 124-124, 2001/03
  • 細胞性製剤の体液性免疫隔離 (1) 細胞固定化担体の補体透過性抑制効果, 鈴木亮,岡宏明,吉岡靖雄,岡田直貴,堤康央,中川晋作,早川尭夫,宮崎純一,真弓忠範, 日本薬学会年会要旨集, Vol. 120th, No. 2, 2000/03/05
  • 細胞性製剤の体液性免疫隔離 (2) 補体失活能を有する新規細胞固定化担体の開発, 岡宏明,鈴木亮,吉岡靖雄,岡田直貴,堤康央,中川晋作,早川尭夫,宮崎純一,真弓忠範, 日本薬学会年会要旨集, Vol. 120th, No. 2, 2000/03/05
  • Cytomedical therapy for diabetes mellitus using microencapsulated pancreatic beta cell line with glucose sensor, Millennial world Congress of Pharmaceutical Sciences, 2000
  • Prolongation of the effective duration of cytomedical therapy by re-injecting SK2 hybridoma cells microencapsulated within alginate-poly(L)lysine-alginate membranes into human interleukin-6 transgenic mice, H Miyamoto,N Okada,T Yoshioka,K Sakamoto,A Katsume,H Saito,Y Tsutsumi,K Kubo,S Nakagawa,Y Ohsugi,T Mayumi, BIOLOGICAL & PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOC JAPAN, Vol. 22, No. 3, p. 295-297, 1999/03
  • Cytomedical therapy for IgG1 plasmacytosis in human interleukin-6 transgenic mice using hybridoma cells microencapsulated in alginate-poly(L)lysine-alginate membrane, N Okada,H Miyamoto,T Yoshioka,A Katsume,H Saito,K Yorozu,O Ueda,N Itoh,H Mizuguchi,S Nakagawa,Y Ohsugi,T Mayumi, BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, ELSEVIER SCIENCE BV, Vol. 1360, No. 1, p. 53-63, 1997/02
  • Immunological studies of SK2 hybridoma cells microencapsulated with alginate-poly(L)lysine-alginate (APA) membrane following allogeneic transplantation, N Okada,H Miyamoto,T Yoshioka,K Sakamoto,A Katsume,H Saito,S Nakagawa,Y Ohsugi,T Mayumi, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS, Vol. 230, No. 3, p. 524-527, 1997/01
  • Development of the novel cytomedical device that can protect against humoral immunity, Millennial world Congress of Pharmaceutical Sciences

Publications

  • Allergy and Immunotoxicology in Occupational Health-The next step, Yoshioka Y,Hirai T,Tsutsumi Y, Springer, 2020
  • 基礎と臨床の両側面からみた胎盤学, 東阪和馬, 吉岡靖雄, 堤 康央, メジカルビュー社, 2019
  • Nanomaterials in Pharmacology, Yoshioka Y,Higashisaka K,Tsutsumi Y, Springer, 2016
  • Reproductive and developmental effects of nanomaterials, Morishita Y,Yoshioka Y,Higashisaka K,Tsutsumi Y, Springer, ISBN:9784431557319, 2016/01
  • Biological Effects of Fibrous and Particulate Substances, Hirai T,Yoshioka Y,Higashisaka K,Tsutsumi Y, Springer, ISBN:9784431557326, 2016/01
  • 生命科学から創薬へのイノベーション, 吉岡靖雄, 南山堂, 2014
  • Engineered Cell Manipulation for Biomedical Application, Yoshioka Y,Higashisaka K,Tsunoda S,Tsutsumi Y, Springer, 2014
  • 遺伝子治療におけるDDS-ベクターの体内動態制御, 吉岡靖雄,中川晋作, NTS出版, 2013
  • 応用が拡がるDDS 人体環境から農業・家電まで, 吉岡靖雄,堤 康央, NTS出版, 2013
  • 開発/製造、登録/輸出入における世界の化学品規制・ルールの解釈と違反回避のための実務, 市橋宏一,平井敏郎,吉岡靖雄,堤 康央, 技術情報協会, 2012
  • ドラッグデリバリーシステムの新展開Ⅱ -核酸医薬・抗体医薬・ワクチン医療を支えるDDS技術-, 平井敏郎,吉岡靖雄,堤 康央, シーエムシー出版, 2012
  • 次世代バイオ医薬品の製剤設計と開発技術, 吉岡靖雄,角田慎一,堤 康央, シーエムシー出版, 2011
  • ペプチド･タンパク性医薬品の新規DDS製剤の開発と応用, 吉岡靖雄,吉川友章,堤 康央, 遺伝子医学MOOK別冊, 2011
  • ナノ材料のリスク評価と安全性対策, 吉川友章,吉岡靖雄,堤 康央, フロンティア出版, 2010
  • Recent Developments in Gene Therapy, Eto Y,Yoshioka Y,Mukai Y,Okada N,Nakagawa S, Research Sigupost in India, 2007
  • 最新医学・別冊 新しい診断と治療のABC, 穐山浩,吉岡靖雄,松田りえ子,米谷民雄

Works

  • 黄砂現象の環境・健康リスクに関する環境科学的研究, 2011 -

Awards

  • 第9回高橋奨励賞, 日本ワクチン学会, 2020/12
  • 大阪大学 総長奨励賞 研究部門, 吉岡 靖雄, 2015
  • 大阪大学 総長奨励賞 研究部門, 吉岡 靖雄, 2014
  • 日本免疫毒性学会 奨励賞, 吉岡 靖雄, 2013
  • 大阪大学 総長奨励賞 研究部門, 吉岡 靖雄, 2013
  • 日本薬学会 奨励賞, 吉岡 靖雄, 2010
  • International Cytokine Society, ICS Young Investigation Award, 吉岡 靖雄, 2009
  • 日本薬学会近畿支部 支部奨励賞, 2003
  • 日本薬剤学会第18年会 最優秀論文発表賞, 2003
  • ファーマ・バイオフォーラム 2002 最優秀発表賞, 2002

Presentations

  • Development of type A CpG oligodeoxynucleotide loaded lipid nanoparticles as an adjuvant for cancer immunotherapy, 2022/10
  • 免疫毒性学的観点からのワクチン開発, 吉岡靖雄, 第27回日本免疫毒性学会学術年会, 2020/09/26
  • 核酸アジュバントの細胞表面受容体の同定と創薬展開, 吉岡靖雄, 日本薬学会第140年会, 2020/03/27
  • For the development of vaccines against infectious diseases., Yasuo Yoshioka, 2019/12/04
  • マイコプラズマ肺炎の病態形成メカニズムの解明とワクチン展開, 吉岡 靖雄, 日本薬学会第139年会, 2019/03/21
  • DDSを活用した感染症に対する最適ワクチンの創成, 吉岡 靖雄, 奈良先端化学技術大学院大学 異分野融合ワークショップ（第2回 臨床医学および免疫学に基づく生体適合性高分子の合成と医用材料設計）, 2019/03/15
  • 感染症対策に資する新規ワクチン開発に向けて, 吉岡 靖雄, 第26回大阪母子医療センターシンポジウム, 2019/02/06
  • 機能性ペプチドによる免疫制御法の開発～感染症ワクチンおよび免疫寛容誘導法の開発～, 吉岡 靖雄, 日本薬学会第137年会, 2017/03
  • Development of novel nano-carrier with safety for vaccine against infectious diseases, 吉岡 靖雄, XIV International Congress of Toxicology, 2016/10
  • 感染症に対する次世代型ワクチンの創成, 吉岡 靖雄, 日本薬学会第136年会, 2016/03
  • 感染症に対する次世代型ワクチンの創成に向けて, 吉岡 靖雄, 第89回日本細菌学会総会, 2016/03
  • Elucidation of immunotoxicity of nanoparticles for developing the sustainable nanotechnology, 吉岡 靖雄, The 2015 International Chemical Congress of Pacific Basin Societies (Pacifichem 2015), 2015/12
  • 脆弱な個体をも対象としたナノ安全科学研究～Sustainable Nanotechnologyを目指して～, 吉岡 靖雄, 第55回日本先天異常学会学術集会, 2015/07
  • 金属系ナノマテリアルのナノ安全科学研究～Sustainable Nanotechnologyを目指して～, 吉岡 靖雄, 第26回日本微量元素学会学術集会, 2015/07
  • Understanding of immunotoxicity of engineered nanomaterials for the sustainable nanotechnology, 吉岡 靖雄, The 31st International Congress on Occupational Health, 2015/06
  • Sustainable Nanotechnologyを目指したナノ安全科学研究, 吉岡 靖雄, 第42回日本毒性学会学術年会, 2015/06
  • ナノ粒子曝露に着眼したアレルギー発症要因の理解に向けて, 吉岡 靖雄, 第88回日本産業衛生学会 アレルギー・免疫毒性研究会, 2015/05
  • サイトカインシグナルを標的とした新規粘膜ワクチンアジュバントの開発に向けて, 吉岡 靖雄, 日本薬学会第135年会, 2015/03
  • Nano-Safety Science for the Sustainable Nanotechnology, 吉岡 靖雄, KANSAI Nano Symposium, 2014/02
  • ナノマテリアルの安全性確保に資する微粒子の免疫毒性評価, 吉岡 靖雄, 第20回日本免疫毒性学会学術大会, 2013/09
  • The importance of systemic nanotoxicological and toxicokinetic analysis for ensuring the safety of nanomaterials, 吉岡 靖雄, The XIII International Congress of Toxicology, 2013/06
  • ナノマテリアルの物性-動態-生体影響の連関評価, 吉岡 靖雄, 第40回日本毒性学会, 2013/06
  • ナノ粒子の安全使用に向けた検討：免疫毒性学の観点から, 吉岡 靖雄, 第40回日本毒性学会, 2013/06
  • ナノマテリアルの持続的な安全使用に向けたナノ安全科学研究, 吉岡 靖雄, 日本薬学会第133年会, 2013/03
  • The importance of nano-safety science for ensuring the safety of nanomaterials, 吉岡 靖雄, The 2nd symposium of “Carbon Nanoforms”, 2012/07
  • The importance of systemic nanotoxicological and toxicokinetic analysis for ensuring the safety of nanomaterials, 吉岡 靖雄, Joint International Conference by KSOT and KSEH, 2012/06
  • ナノ安全科学研究の最前線：ナノマテリアルの安全性解析と安全なナノマテリアルの開発支援に向けて, 吉岡 靖雄, 技術情報協会セミナー, 2012/04
  • Conclusion ～ナノマテリアルの開発・安全性評価の将来展望～, 吉岡 靖雄, 日本薬学会第132年会, 2012/03
  • 大学の取組：ナノマテリアルの安全性評価と安全なナノマテリアルの開発支援 ～ナノ安全科学研究の現状と今後～, 吉岡 靖雄, 日本薬学会第132年会, 2012/03
  • ナノマテリアルの安全性評価研究, 吉岡 靖雄, 第4回次世代アジュバント研究会, 2012/02
  • レセプター指向性を有する蛋白性アンタゴニストの創製と自己免疫疾患治療への展開, 吉岡 靖雄, 健康長寿(SONIC)研究会, 2012/01
  • The importance of systemic nanotoxicological and toxicokinetic analysis for ensuring the safety of nanomaterials, 吉岡 靖雄, Gordon Research conference, 2011/05
  • ナノマテリアルの安全性確保を目指して, 吉岡 靖雄, 第80回日本衛生学会学術総会, 2010/05
  • レセプター指向性を有する蛋白性アンタゴニストの創製と自己免疫疾患治療への展開（奨励賞受賞講演）, 吉岡 靖雄, 日本薬学会第130年会, 2010/03
  • ナノマテリアルの安全確保に向けたNanoTox研究の最前線（総括）, 吉岡 靖雄, 日本薬学会第130年会, 2010/03
  • ナノマテリアルの動態特性と免疫毒性, 吉岡 靖雄, 日本薬学会第130年会, 2010/03

Committee Memberships

  • 日本食品化学学会, 編集委員, -
  • 一般社団法人 臨床医工情報学 コンソーシアム関西, アドバイザー, -
  • 文部科学省 科学技術・学術政策研究所 科学技術予測センター, 専門調査員, -
  • 一般社団法人 日本化学工業協会, LRI学術諮問会議委員, -
  • 日本薬学会関西支部, 委員, -
  • 日本DDS学会, 評議員, -
  • 日本毒性学会 評議員, -
  • 日本免疫毒性学会 理事, -
  • 日本薬学会 代議員, -