網羅的匂い分子解析のリアルタイム定量化を目指したヒト嗅覚受容体発現細胞の樹立

中村 実世, 立松 健司, 山崎 智子, 黒田 俊一

日本生物工学会大会講演要旨集　Vol. 平成30年度　p. 290-290　2018/08

Establishment of human olfactory receptor-expressing cell lines for high throughput odorant analysis.

Nakamura M, Yamazaki T, Takai M, Tatematsu K, Kuroda S

2018/01

Deciphering the Receptor Repertoire Encoding Specific Odorants by Time-Lapse Single-Cell Array Cytometry

Suzuki M, Yoshimoto N, Shimono K, Kuroda S

Scientific Reports　Vol. 6　p. 19934-19934　2016/02/02　Research paper (scientific journal)

特定の匂い分子に応答する嗅覚受容体群の網羅的取得法

良元伸男, 黒田俊一

Aroma Research　Vol. 17　No. 3　p. 41-45　2016

Human Olfactory Receptor Sensor for Odor Reconstitution

Shun’ichi Kuroda, Yukiko Nakaya-Kishi, Kenji Tatematsu, Shuji Hinuma

Sensors　Vol. 23　No. 13　p. 6164-6164　2023/07/05　Research paper (scientific journal)

Immunostick colorimetric assay for highly sensitive detection of food allergens by bio-nanocapsule-scaffolding technology

Yuto Sasamura, Seri Yamamoto, Akiko Tanabe, Kota Kera, Shun'ichi Kuroda, Tsutomu Nakayama, Masumi Iijima

Bioscience, Biotechnology, and Biochemistry　Vol. 87　No. 7　p. 765-770　2023/04/24　Research paper (scientific journal)

Mass-Fabrication Scheme of Highly Sensitive Wireless Electrodeless MEMS QCM Biosensor with Antennas on Inner Walls of Microchannel

Lianjie Zhou, Fumihito Kato, Masumi Iijima, Tomoyuki Nonaka, Shun’ichi Kuroda, Hirotsugu Ogi

Analytical Chemistry　2023/03/24　Research paper (scientific journal)

Changes in Olfactory Receptor Responses in the Modulatory Action of Sensuous Deodorization

MITSUDA Megumi, TAKESHITA Goushi, HANAOKA Sanae, KONDO Saki, TATEMATSU Kenji, KURODA Shun'ichi

Journal of human and living environment　Vol. 30　No. 1　p. 1-8　2023

Chapter 11 Oriented immobilization of biomolecules on small surfaces

Masumi Iijima, Shun'ichi Kuroda

Biocatalyst Immibolization: Foundations and Applications　p. 249-268　2023

Specific Binding and Endocytosis of Liposomes to HEK293T Cells via Myrisoylated Pre-S1 Peptide Bound to Sodium Taurocholate Cotransporting Polypeptide

Shuji Hinuma, Kazuyo Fujita, Shun’ichi Kuroda

Vaccines　Vol. 10　No. 12　p. 2050-2050　2022/11/30　Research paper (scientific journal)

Nano-visualization of the in vitro antiviral activity of black tea based on production area using a liposome-based virus membrane model.

Masumi Iijima, Atsushi Kawaguchi, Yukino Ogura, Ryotaro Yoshimoto, Moemi Kaneda, Kota Kera, Shun'ichi Kuroda, Tsutomu Nakayama

Bioscience, biotechnology, and biochemistry　Vol. 86　No. 12　p. 1658-1669　2022/11/23　Research paper (scientific journal)

Mechanical detection of interactions between proteins related to intermediate filament and transcriptional regulation in living cells

Ayana Yamagishi, Mei Mizusawa, Koki Uchida, Masumi Iijima, Shun’ichi Kuroda, Kyoko Fukazawa, Kazuhiko Ishihara, Chikashi Nakamura

Biosensors and Bioelectronics　Vol. 216　p. 114603-114603　2022/11　Research paper (scientific journal)

Engineering of Extracellular Vesicles for Small Molecule-Regulated Cargo Loading and Cytoplasmic Delivery of Bioactive Proteins.

Masaharu Somiya, Shun'ichi Kuroda

Molecular pharmaceutics　2022/05/20　Research paper (scientific journal)

Verification of extracellular vesicle-mediated functional mRNA delivery via RNA editing

Somiya, Masaharu, Kuroda, Shun'ichi

bioRxiv　2022/01/26

Binding of Hepatitis B Virus Pre-S1 Domain-Derived Synthetic Myristoylated Peptide to Scavenger Receptor Class B Type 1 with Differential Properties from Sodium Taurocholate Cotransporting Polypeptide

Shuji Hinuma, Shun’ichi Kuroda

Viruses　Vol. 14　No. 1　p. 105-105　2022/01/07　Research paper (scientific journal)

Bio-nanocapsules for oriented immobilization of DNA aptamers on aptasensors

Masumi Iijima, Yuki Yamada, Hideo Nakano, Tsutomu Nakayama, Shun'ichi Kuroda

The Analyst　Vol. 147　No. 3　p. 489-495　2022/01　Research paper (scientific journal)

Functional and structural characterization of a flavoprotein monooxygenase essential for biogenesis of tryptophylquinone cofactor

Toshinori Oozeki, Tadashi Nakai, Kazuki Kozakai, Kazuki Okamoto, Shun’ichi Kuroda, Kazuo Kobayashi, Katsuyuki Tanizawa, Toshihide Okajima

Nature Communications　Vol. 12　No. 1　2021/12　Research paper (scientific journal)

Binding of Nanoparticles Harboring Recombinant Large Surface Protein of Hepatitis B Virus to Scavenger Receptor Class B Type 1

Shuji Hinuma, Kazuyo Fujita, Shun’ichi Kuroda

Viruses　Vol. 13　No. 7　p. 1334-1334　2021/07/10　Research paper (scientific journal)

Binding of liposomes composed of phosphatidylcholine to scavenger receptor class B type 1 and its modulation by phosphatidic acid in HEK293T cells

Narumi Koide, Kazuyo Fujita, Shun'ichi Kuroda, Shuji Hinuma

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research　Vol. 1868　No. 7　p. 119043-119043　2021/06/14　Research paper (scientific journal)

HBV Pre-S1-Derived Myristoylated Peptide (Myr47): Identification of the Inhibitory Activity on the Cellular Uptake of Lipid Nanoparticles

Masaya Nanahara, Ya-Ting Chang, Masaharu Somiya, Shun'ichi Kuroda

Viruses　Vol. 13　No. 5　p. 929-929　2021/05/17　Research paper (scientific journal)

Polymerized Albumin Receptor of Hepatitis B Virus for Evading the Reticuloendothelial System

Kurumi Takagi, Masaharu Somiya, Joohee Jung, Masumi Iijima, Shun'ichi Kuroda

Pharmaceuticals　2021/04　Research paper (scientific journal)

Id2 Represses Aldosterone-Stimulated Cardiac T-Type Calcium Channels Expression.

Jumpei Ito, Tomomi Minemura, Sébastien Wälchli, Tomoaki Niimi, Yoshitaka Fujihara, Shun'ichi Kuroda, Koichi Takimoto, Andrés D Maturana

International journal of molecular sciences　Vol. 22　No. 7　2021/03/30　Research paper (scientific journal)

Cytoplasmic delivery of small interfering RNA by photoresponsive non-cationic liposomes

Masaharu Somiya, Kanako Sakaeda, Yuta Ishii, Shun’ichi Kuroda

Journal of Drug Delivery Science and Technology　p. 102488-102488　2021/03　Research paper (scientific journal)

Real-Time Luminescence Assay for Cytoplasmic Cargo Delivery of Extracellular Vesicles

Masaharu Somiya, Shun’ichi Kuroda

Analytical Chemistry　2021/03　Research paper (scientific journal)

Reporter gene assay for membrane fusion of extracellular vesicles

Masaharu Somiya, Shun’ichi Kuroda

2021/02/17

Enhancing antibody-dependent cellular phagocytosis by Re-education of tumor-associated macrophages with resiquimod-encapsulated liposomes.

Hao Li, Masaharu Somiya, Shun'ichi Kuroda

Biomaterials　Vol. 268　p. 120601-120601　2021/01　Research paper (scientific journal)

A regulatory role of scavenger receptor class B type 1 in endocytosis and lipid droplet formation induced by liposomes containing phosphatidylethanolamine in HEK293T cells

Kazuyo Fujita, Narumi Koide, Masaharu Somiya, Shun'ichi Kuroda, Shuji Hinuma

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research　Vol. 1868　No. 1　p. 118859-118859　2021/01　Research paper (scientific journal)

Influence of Nivolumab for Intercellular Adhesion Force between a T Cell and a Cancer Cell Evaluated by AFM Force Spectroscopy

Hyonchol Kim, Kenta Ishibashi, Masumi Iijima, Shun’ichi Kuroda, Chikashi Nakamura

Sensors　Vol. 20　No. 19　p. 5723-5723　2020/10/08　Research paper (scientific journal)

Digital Pathology Platform for Respiratory Tract Infection Diagnosis via Multiplex Single-Particle Detections

Akihide Arima, Makusu Tsutsui, Takeshi Yoshida, Kenji Tatematsu, Tomoko Yamazaki, Kazumichi Yokota, Shun’ichi Kuroda, Takashi Washio, Yoshinobu Baba, Tomoji Kawai

ACS Sensors　Vol. 5　No. 11　p. 3398-3403　2020/09/25　Research paper (scientific journal)

Enhanced sugar chain detection by oriented immobilization of Fc-fused lectins

Masumi Iijima, Yuki Yamada, Tsutomu Nakayama, Shun'ichi Kuroda

Bioscience, Biotechnology, and Biochemistry　Vol. 84　No. 9　p. 1775-1779　2020/09/01　Research paper (scientific journal)

A Novel Hybrid Drug Delivery System for Treatment of Aortic Aneurysms

Koichi Yoshimura, Hiroki Aoki, Chie Teruyama, Masumi Iijima, Hiromori Tsutsumi, Shun’ichi Kuroda, Kimikazu Hamano

International Journal of Molecular Sciences　Vol. 21　No. 15　p. 5538-5538　2020/08/02　Research paper (scientific journal)

Mechanism of affinity-enhanced protein adsorption on bio-nanocapsules studied by viscoelasticity measurement with wireless QCM biosensor

Kentaro Noi, Masumi Iijima, Shun’ichi Kuroda, Fumihito Kato, Hirotsugu Ogi

Japanese Journal of Applied Physics　Vol. 59　No. SK　p. SKKB03-SKKB03　2020/07/01　Research paper (scientific journal)

Development of a universal method for the measurement of binding affinities of antibody drugs towards a living cell based on AFM force spectroscopy

Hyonchol Kim, Masamichi Hoshi, Masumi Iijima, Shun'ichi Kuroda, Chikashi Nakamura

Analytical Methods　Vol. 12　No. 22　p. 2922-2927　2020/06　Research paper (scientific journal)

Virus-mimicking nanocarriers for the intracellular delivery of therapeutic biomolecules.

Masaharu Somiya, Shun'ichi Kuroda

Nanomedicine (London, England)　Vol. 15　No. 12　p. 1163-1165　2020/05

Two-dimensional membrane scaffold for the oriented immobilization of biosensing molecules

Masumi Iijima, Tsutomu Nakayama, Shun'ichi Kuroda

Biosensors and Bioelectronics　Vol. 150　p. 111860-111860　2020/02　Research paper (scientific journal)

Carrier development for biopharmaceuticals: Bio-nanocapsules based on the early infection machinery of hepatitis B virus

Masaharu Somiya, Shun'ichi Kuroda

Drug Delivery System　Vol. 35　No. 1　p. 57-63　2020　Research paper (scientific journal)

Construction of a Macrophage-Targeting Bio-nanocapsule-Based Nanocarrier.

Hao Li, Masaharu Somiya, Kenji Tatematsu, Shun'ichi Kuroda

Methods in molecular biology (Clifton, N.J.)　Vol. 2059　p. 299-313　2020　Research paper (scientific journal)

[DDS Nanocarriers Mimicking Early Infection Machinery of Viruses].

Masaharu Somiya, Shun'ichi Kuroda

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan　Vol. 140　No. 2　p. 147-152　2020　Research paper (scientific journal)

バイオミミック技術によるウイルスの感染機構を搭載したDDSナノキャリアの開発

曽宮正晴, 黒田俊一

薬学雑誌　Vol. 140　No. 2　p. 147-152　2020

バイオ医薬に利用されるキャリア開発：B型肝炎ウイルスの初期感染機構に基づくバイオナノカプセル

曽宮正晴, 黒田俊一

DDS学会誌　Vol. 35　No. 1　p. 57-63　2020

In vivo uterine local gene delivery system using TAT‐displaying bionanocapsules

Kaori Koizumi, Hitomi Nakamura, Masumi Iijima, Takashi Matsuzaki, Masaharu Somiya, Keiichi Kumasawa, Tadashi Kimura, Shun'ichi Kuroda

The Journal of Gene Medicine　Vol. 21　No. 12　2019/12　Research paper (scientific journal)

Ultrahigh-sensitive wireless QCM with bio-nanocapsules

Kentaro Noi, Masumi Iijima, Shun’ichi Kuroda, Hirotsugu Ogi

Sensors and Actuators B: Chemical　Vol. 293　p. 59-62　2019/08　Research paper (scientific journal)

NF-κB転写阻害因子(MTI-II)由来6アミノ酸ペプチド(sMPAID)の抗炎症作用

岡本 一起, 立松 健司, 黒田 俊一

ビタミン　Vol. 93　No. 4　p. 189-189　2019/04

Oriented immobilization to nanoparticles enhanced the therapeutic efficacy of antibody drugs

Iijima M, Araki K, Liu Q, Somiya M, Kuroda S.

Acta Biomaterialia　Vol. 86　p. 373-380　2019/03　Research paper (scientific journal)

Robo2 contains a cryptic binding site for neural EGFL-like (NELL) protein 1/2

N. Yamamoto, M. Kashiwagi, M. Ishihara, T. Kojima, A. D. Maturana, S. Kuroda, T. Niimi

J Biol Chem　Vol. 294　No. 12　p. 4693-4703　2019/03　Research paper (scientific journal)

Identifying multiple single viruses using nanopore sensors

Arima Akihide, Tsutsui Makusu, Tonomura Wataru, Yokota Kazumichi, Tatematsu Kenji, Yamazaki Tomoko, Kuroda Shun'ichi, Taniguchi Masateru, Washio Takashi, Kawai Tomoji

JSAP Annual Meetings Extended Abstracts　Vol. 2019.1　p. 2513-2513　2019/02/25

Induction of lipid droplets in non-macrophage cells as well as macrophages by liposomes and exosomes

Kazuyo Fujita, Masaharu Somiya, Shun'ichi Kuroda, Shuji Hinuma

Biochemical and Biophysical Research Communications　Vol. 510　No. 1　p. 184-190　2019/02　Research paper (scientific journal)

Identifying multiple viral species at a single particle level using a combination of nanopores and machine leaning approach

Akihide Arima, Makusu Tsutsui, Yoshida Takeshi, Kazumichi Yokota, Wataru Tonomura, Takao Yasui, Taisuke Shimada, Tomoko Yamazaki, Kenji Tatematsu, Shunichi Kuroda, Masateru Taniguchi, Takashi Washio, Tomoji Kawai, Yoshinobu Baba

23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019　p. 1238-1239　2019　Research paper (international conference proceedings)

エンベロープウイルスやエクソソームを利用したドラッグデリバリーシステムの開発

曽宮正晴, 黒田俊一

膜　Vol. 44　p. 222-227　2019

High-throughput single nanoparticle detection using a feed-through channel-integrated nanopore

Makusu Tsutsui, Tomoko Yamazaki, Kenji Tatematsu, Kazumichi Yokota, Yuko Esaki, Yukari Kubo, Hiroko Deguchi, Akihide Arima, Shun'ichi Kuroda, Tomoji Kawai

Nanoscale　Vol. 11　No. 43　p. 20475-20484　2019　Research paper (scientific journal)

The Structural Function of Nestin in Cell Body Softening is Correlated with Cancer Cell Metastasis

Ayana Yamagishi, Moe Susaki, Yuta Takano, Mei Mizusawa, Mari Mishima, Masumi Iijima, Shun'ichi Kuroda, Tomoko Okada, Chikashi Nakamura

International Journal of Biological Sciences　Vol. 15　No. 7　p. 1546-1556　2019　Research paper (scientific journal)

A hepatitis B virus-derived human hepatic cell-specific heparin-binding peptide: identification and application to a drug delivery system

Qiushi Liu, Masaharu Somiya, Masumi Iijima, Kenji Tatematsu, Shun'ichi Kuroda

Biomaterials Science　Vol. 7　No. 1　p. 322-335　2019　Research paper (scientific journal)

CD11c-specific bio-nanocapsule enhances vaccine immunogenicity by targeting immune cells

Hidenori Matsuo, Masaharu Somiya, Masumi Iijima, Takeshi Arakawa, Shun’ichi Kuroda

Journal of Nanobiotechnology　Vol. 16　No. 1　p. 59-59　2018/12　Research paper (scientific journal)

Identifying single viruses using nanopore sensors

Arima Akihide, Tsutsui Makusu, Tonomura Wataru, Yokota Kazumichi, Tatematsu Kenji, Yamazaki Tomoko, Kuroda Shun'ichi, Taniguchi Masateru, Washio Takashi, Kawai Tomoji

JSAP Annual Meetings Extended Abstracts　Vol. 2018.2　p. 2648-2648　2018/09/05

NF-κBコリプレッサー(MTI-II)の作用部位由来6アミノ酸ペプチドのin vivo抗炎症作用

岡本 一起, 立松 健司, 黒田 俊一

日本生化学会大会プログラム・講演要旨集　Vol. 91回　p. [1P-329]　2018/09

Automated Single-Cell Analysis and Isolation System: A Paradigm Shift in Cell Screening Methods for Bio-medicines.

K. Tatematsu, S. Kuroda

Adv Exp Med Biol　2018/06　Research paper (scientific journal)

Development of a macrophage-targeting and phagocytosis-inducing bio-nanocapsule-based nanocarrier for drug delivery

Hao Li, Kenji Tatematsu, Masaharu Somiya, Masumi Iijima, Shun'ichi Kuroda

Acta Biomaterialia　Vol. 73　p. 412-423　2018/06/01　Research paper (scientific journal)

ファゴサイトーシスを誘導するバイオナノカプセルを用いたマクロファージ標的化ドラッグデリバリーシステム

李 昊, 曽宮 正晴, 立松 健司, 黒田 俊一

日本DDS学会学術集会プログラム予稿集　Vol. 34回　p. 168-168　2018/05

Low immunogenic bio-nanocapsule based on hepatitis B virus escape mutants

Jung J, Somiya M, Jeong SY, Choi EK, Kuroda S.

Nanomedicine: Nanotechnology, Biology and Medicine　Vol. 14　No. 2　p. 595-600　2018/02　Research paper (scientific journal)

Albumin-Encapsulated Liposomes: A Novel Drug Delivery Carrier With Hydrophobic Drugs Encapsulated in the Inner Aqueous Core

Okamoto Y, Taguchi K, Yamasaki K, Sakuragi M, Kuroda S, Otagiri M.

Journal of Pharmaceutical Sciences　Vol. 107　No. 1　p. 436-445　2018/01/01　Research paper (scientific journal)

Bio-nanocapsule-based scaffold for clustering and oriented-immobilization of sensing molecules.

Yamada Y, Iijima M, Kuroda S

2018/01

A New Cell Separation Method Based on Antibody-Immobilized Nanoneedle Arrays for the Detection of Intracellular Markers

Kawamura R, Miyazaki M, Shimizu K, Matsumoto Y, Silberberg YR, Sathuluri RR, Iijima M, Kuroda S, Iwata F, Kobayashi T, Nakamura C.

Nano Letters　Vol. 17　No. 11　p. 7117-7124　2017/11/08　Research paper (scientific journal)

Mechanical Separation of Neural Stem Cell Derived from Human iPS Cell Using Nanoneedle Array

Matsumoto Y, Shimizu K, Kawamura R, Yamagishi A, Iijima M, Kuroda S, Nakamura C

2017/11

Evaluation of mechanical property of intermediate filament related with stiffness of breast cancer cell by use of nanoneedle and AFM

Yamagishi A, Susaki M, Takano U, Iijima M, Kuroda S, Okada T, Nagasaki A, Nakamura C

2017/11　Research paper (other academic)

Innovative method for oriented and closed-packed immobilization of immunoglobulins Iijima M., Kuroda S.

Iijima M, Kuroda S

Atlas of Science (2017)　2017/10

Preclinical evaluation of cisplatin-incorporated bio-nanocapsules as chemo-radiotherapy for human hepatocellular carcinoma

Seol Hwa Shin, Seok Soon Park, Kyoung Jin Lee, Eun Jin Ju, Jin Park, Eun Jeong Ko, Joohee Jung, Shun'ich Kuroda, Seung-Mo Hong, Jung Jin Hwang, Jung Shin Lee, Si Yeol Song, Seong-Yun Jeong, Eun Kyung Choi

Oncology Reports　Vol. 38　No. 4　p. 2259-2266　2017/10/01　Research paper (scientific journal)

Development of scaffolding molecule for improving function of biomolecules

M. Iijima, S. Kuroda

FEBS JOURNAL　Vol. 284　p. 333-333　2017/09

抗体提示型GL-Virosomeによるマクロファージ特異的薬剤送達法の開発

李 昊, 立松 健司, 曽宮 正晴, 黒田 俊一

日本生物工学会大会講演要旨集　Vol. 平成29年度　p. 166-166　2017/08

B型肝炎ウイルス感染機構に基づくNF-κB転写活性抑制ペプチドsMPAIDの肝臓特異的送達法の開発

徐 子暢, 立松 健司, 岡本 一起, 曽宮 正晴, 黒田 俊一

日本生物工学会大会講演要旨集　Vol. 平成29年度　p. 169-169　2017/08

Synthesis and assembly of Hepatitis B virus envelope protein-derived particles in Escherichia coli

Hao Li, Keisuke Onbe, Qiushi Liu, Masumi Iijima, Kenji Tatematsu, Masaharu Seno, Hiroko Tada, Shun’ ichi Kuroda

Biochemical and Biophysical Research Communications　Vol. 490　No. 2　p. 155-160　2017/08　Research paper (scientific journal)

Capsular- and Planar-Scaffold for Clustering and Oriented Immobilization of Sensing Molecules.

Iijima M, Kuroda S

2017/06

Planar membrane displaying IgGs in an oriented immobilization manner for biosensor surface.

2017/05

Scaffolds for oriented and close-packed immobilization of immunoglobulins

Masumi Iijima, Shun'ichi Kuroda

Biosensors and Bioelectronics　Vol. 89　p. 810-821　2017/03/15

Current Progress of Virus-mimicking Nanocarriers for Drug Delivery

Somiya M, Liu Q, Kuroda S.

Nanotheranostics　Vol. 1　No. 4　p. 415-429　2017　Research paper (scientific journal)

センシング分子の精密整列化技術

飯嶋益巳, 黒田俊一

月刊「ケミカル・エンジニヤリング」　Vol. 62　No. 11　p. 1-7　2017

Issues in the entrepreneurization and commercialization of academic research-based DDS technology

Drug delivery system : DDS : official journal of the Japan Society of Drug Delivery System　Vol. 32　No. 4　p. 251-258　2017

Automated Single-Cell Analysis and Isolation System: Basics and Applications—:A Paradigm Shift in the Cell Screening System by Single-Cell Isolation Robot

TATEMATSU Kenji, KURODA Shun'ichi

KAGAKU TO SEIBUTSU　Vol. 55　No. 10　p. 684-689　2017

High efficiency penetration of antibody-immobilized nanoneedle thorough plasma membrane for in situ detection of cytoskeletal proteins in living cells

R. Kawamura, K. Shimizu, Y. Matsumoto, A. Yamagishi, Y. R. Silberberg, M. Iijima, S. Kuroda, K. Fukazawa, K. Ishihara, C. Nakamura

Journal of Nanobiotechnology　Vol. 14　No. 1　p. 74-74　2016/12　Research paper (scientific journal)

Cellular uptake of hepatitis B virus envelope L particles is independent of sodium taurocholate cotransporting polypeptide, but dependent on heparan sulfate proteoglycan

Somiya M, Liu Q, Yoshimoto N, Iijima M, Tatematsu K, Nakai T, Okajima T, Kuroki K, Ueda K, Kuroda S

Virology　Vol. 497　p. 23-32　2016/10　Research paper (scientific journal)

様々な抗体を提示可能なバイオナノカプセルによる能動的標的化DDSナノキャリアの開発

立松 健司, 李 昊, 飯嶋 益巳, 黒田 俊一

日本生物工学会大会講演要旨集　Vol. 平成28年度　p. 124-124　2016/08

Cytokine-Dependent Activation of JAK-STAT Pathway in Saccharomyces cerevisiae

Yoshimoto N, Ikeda Y, Tatematsu K, Iijima M, Nakai T, Okajima T, Tanizawa K, Kuroda S.

BIOTECHNOLOGY AND BIOENGINEERING　Vol. 113　No. 8　p. 1796-1804　2016/08　Research paper (scientific journal)

RBM20 and RBM24 cooperatively promote the expression of shortenhsplice variants

Ito J, Iijima M, Yoshimoto N, Niimi T, Kuroda S, Maturana A.

FEBS Letters　Vol. 590　No. 14　p. 2262-2274　2016/07　Research paper (scientific journal)

Core-fucosylation plays a pivotal role in hepatitis B pseudo virus infection: a possible implication for HBV glycotherapy

Takamatsu S, Shimomura M, Kamada Y, Maeda H, Sobajima T, Hikita H, Iijima M, Okamoto Y, Misaki R, Fujiyama K, Nagamori S, Kanai Y, Takehara T, Ueda K, Kuroda S, Miyoshi E

Glycobiology　Vol. 26　No. 11　p. 1180-1189　2016/06/21　Research paper (scientific journal)

Bio-nanocapsule-based scaffold improves the sensitivity and ligand-binding capacity of mammalian receptors on the sensor chip

Iijima M, Yoshimoto N, Niimi T, Maturana AD, Kuroda S.

BIOTECHNOLOGY JOURNAL　Vol. 11　No. 6　p. 805-813　2016/06　Research paper (scientific journal)

Scaffold protein enigma homolog 1 overcomes the repression of myogenesis activation by inhibitor of DNA binding 2

Nakatani M, Ito J, Koyama R, Iijima M, Yoshimoto N, Niimi T, Kuroda S, Maturana AD

Biochemical and Biophysical Research Communications　Vol. 474　No. 2　p. 413-420　2016/05/27　Research paper (scientific journal)

Mutational analysis of hepatitis B virus pre-S1 (9-24) fusogenic peptide

Liu Q, Somiya M, Shimada N, Sakamoto W, Yoshimoto N, Iijima M, Tatematsu K, Nakai T, Okajima T, Maruyama A, Kuroda S.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 474　No. 2　p. 406-412　2016/05　Research paper (scientific journal)

Bio-nanocapsules displaying various immunoglobulins as an active targeting-based drug delivery system

Tatematsu K, Iijima M, Yoshimoto N, Nakai T, Okajima T, Kuroda S.

Acta Biomaterialia　Vol. 35　p. 238-247　2016/04　Research paper (scientific journal)

Effect of PEGylation on the physicochemical and pharmacokinetic characteristics of bovine serum albumin-encapsulated liposome

Yuko Okamoto, Kazuaki Taguchi, Keishi Yamasaki, Mina Sakuragi, Shun'ichi Kuroda, Masaki Otagiri

Asian Journal of Pharmaceutical Sciences　Vol. 11　No. 1　p. 112-113　2016/02　Research paper (scientific journal)

Potential of a non-cationic liposomes-based delivery system for nucleic acid medicines

Somiya Masaharu, Kuroda Shun'ichi

Drug Deliv Syst　Vol. 31　No. 1　p. 35-43　2016/01/25

Elucidation of the early infection machinery of hepatitis B virus by using bio-nanocapsule

Qiushi Liu, Masaharu Somiya, Shun’ichi Kuroda

World Journal of Gastroenterology　Vol. 22　No. 38　p. 8489-8496　2016　Research paper (scientific journal)

Development of Drug Delivery System Nanocarrier by Biomimicking Technology : Bio-Nanocapsule Based on Hepatitis B Virus Early Infection Machinery

Vol. 45　No. 11　p. 18-24　2016

生体分子の整列固定化法

飯嶋益巳, 黒田俊一

日本生物工学会誌　Vol. 94　No. 8　p. 497-497　2016

Automated isolation and analysis system of single-cell for developing novel cell-breeding technology

Vol. 74　No. 1　p. 30-33　2016

Release of siRNA from Liposomes Induced by Curcumin

Fujita K, Hiramatsu Y, Minematsu H, Somiya M, Kuroda S, Seno M, Hinuma S.

Journal of Nanotechnology　Vol. 2016　p. 1-6　2016　Research paper (scientific journal)

Mapping the heparin-binding site of the osteoinductive protein NELL1 by site-directed mutagenesis

Takahashi K, Imai A, Iijima M, Yoshimoto N, Maturana AD, Kuroda S, Niimi T.

FEBS Letters　Vol. 589　No. 24PartB　p. 4026-4032　2015/12/21　Research paper (scientific journal)

Development of a virus-mimicking nanocarrier for drug delivery systems: The bio-nanocapsule

Masaharu Somiya, Shun'ichi Kuroda

ADVANCED DRUG DELIVERY REVIEWS　Vol. 95　p. 77-89　2015/12

Scaffold protein enigma homolog activates CREB whereas a short splice variant prevents CREB activation in cardiomyocytes

Ito J, Iijima M, Yoshimoto N, Niimi T, Kuroda S, and Maturana AD.

CELLULAR SIGNALLING　Vol. 27　No. 12　p. 2425-2433　2015/12　Research paper (scientific journal)

Bio-nanocapsule(BNC)を用いた子宮局所への新しいdrug delivery systemの構築

小泉 花織, 中村 仁美, 松崎 高志, 黒田 俊一, 瀧内 剛, 熊澤 恵一, 木村 正

Reproductive Immunology and Biology　Vol. 30　No. 1-2　p. 13-21　2015/11

バイオナノカプセルを用いた抗炎症タンパク質MTI-IIの生体内ピンポイント送達法の開発

立松 健司, 岡本 一起, 飯嶋 益巳, 黒田 俊一

日本生物工学会大会講演要旨集　Vol. 平成27年度　p. 327-327　2015/09

Intracellular trafficking of bio-nanocapsule–liposome complex: Identification of fusogenic activity in the pre-S1 region of hepatitis B virus surface antigen L protein

Somiya M, Sasaki Y, Matsuzaki T, Liu Q, Iijima M, Yoshimoto N, Niimi T, Maturana AD, Kuroda S

Journal of Controlled Release　Vol. 212　p. 10-18　2015/08　Research paper (scientific journal)

One-step scalable preparation method for non-cationic liposomes with high siRNA content

Somiya M, Yamaguchi K, Liu Q, Niimi T, Maturana AD, Iijima M, Yoshimoto N, Kuroda S.

INTERNATIONAL JOURNAL OF PHARMACEUTICS　Vol. 490　No. 1-2　p. 316-323　2015/07　Research paper (scientific journal)

Virosomes of hepatitis B virus envelope L proteins containing doxorubicin: synergistic enhancement of human liver-specific antitumor growth activity by radiotherapy.

Shun'ichi Kuroda, Qiushi Liu, Joohee Jung, Masumi Iijima, Nobuo Yoshimoto, Tomoaki Niimi, Andrés Maturana, Seol Hwa Shin, Seong-Yun Jeong, Eun Kyung Choi, Masaharu Somiya

International Journal of Nanomedicine　Vol. 10　p. 4159-4172　2015/06/25　Research paper (scientific journal)

A cisplatin-incorporated liposome that targets the epidermal growth factor receptor enhances radiotherapeutic efficacy without nephrotoxicity

Jung J, Jeong SY, Park SS, Shin SH, Ju EJ, Choi J, Park J, Lee JH, Kim I, Suh YA, Hwang JJ,Kuroda S, Lee JS, Song SY and Choi EK

International Journal of Oncology　Vol. 46　No. 3　p. 1268-1274　2015/03/01　Research paper (scientific journal)

Bio-nanocapsule-based scaffold for biosensing molecules: Enhancement ofsensitivity by the clustering and oriented immobilization of sensing molecules

Masumi Iijima, Shun'Ichi Kuroda

Seibutsu-kogaku Kaishi　Vol. 93　No. 5　p. 248-258　2015　Research paper (scientific journal)

バイオナノカプセルを用いたセンシング分子整列化技術によるバイオセンシングの高感度化

飯嶋益巳, 黒田 俊一

生物工学会誌　Vol. 93　p. 248-258　2015

Bio-nanocapsule(BNC)を用いた子宮局所への新しいdrug delivery systemの構築

小泉 花織, 中村 仁美, 松崎 高志, 黒田 俊一, 瀧内 剛, 熊澤 恵一, 木村 正

Reproductive Immunology and Biology　Vol. 29　No. 1-2　p. 82-82　2014/11

Specific delivery of microRNA93 into HBV-replicating hepatocytes downregulates protein expression of liver cancer susceptible gene MICA

Motoko Ohno, Motoyuki Otsuka, Takahiro Kishikawa, Chikako Shibata, Takeshi Yoshikawa, Akemi Takata, Ryosuke Muroyama, Norie Kowatari, Masaya Sato, Naoya Kato, Shun’ichi Kuroda, Kazuhiko Koike

Oncotarget　Vol. 5　No. 14　p. 5581-5590　2014/07/30　Research paper (scientific journal)

Oligomerization-induced Conformational Change in the C-terminal Region of Nel-like Molecule 1 (NELL1) Protein Is Necessary for the Efficient Mediation of Murine MC3T3-E1 Cell Adhesion and Spreading

Yoko Nakamura, Ai Hasebe, Kaneyoshi Takahashi, Masumi Iijima, Nobuo Yoshimoto, Andrés D. Maturana, Kang Ting, Shun'ichi Kuroda, Tomoaki Niimi

Journal of Biological Chemistry　Vol. 289　No. 14　p. 9781-9794　2014/04/04　Research paper (scientific journal)

Single-cell-based breeding: Rational strategy for the establishment of cell lines from a single cell with the most favorable properties

Nobuo Yoshimoto, Shun'ichi Kuroda

Journal of Bioscience and Bioengineering　Vol. 117　No. 4　p. 394-400　2014/04　Research paper (scientific journal)

High-throughput de novo screening of receptor agonists with an automated single-cell analysis and isolation system

Yoshimoto N, Tatematsu K, Iijima M, Niimi T, Maturana AD, Fujii I, Kondo A, Tanizawa K, Kuroda S

Scientific Reports　Vol. 4　p. 4242-4250　2014/02/28

全自動１細胞解析単離装置（ASONECell Picking System）の開発

黒田俊一

BB Chubu　No. 5　p. 15-20　2014

ウイルス表面抗原タンパク質提示によるリポソームへの標的化能，細胞内侵入能，およびステルス能の付与

黒田俊一

膜　Vol. 39　p. 283-289　2014

Enhanced OH radical generation by dual-frequency ultrasound with TiO2 nanoparticles: Its application to targeted sonodynamic therapy

Kazuaki Ninomiya, Kyohei Noda, Chiaki Ogino, Shun-ichi Kuroda, Nobuaki Shimizu

ULTRASONICS SONOCHEMISTRY　Vol. 21　No. 1　p. 289-294　2014/01　Research paper (scientific journal)

A bio-nanocapsule containing envelope protein domain III of Japanese encephalitis virus protects mice against lethal Japanese encephalitis virus infection

Takeshi Miyata, Senji Tafuku, Tetsuya Harakuni, Masayuki Tadano, Nobuo Yoshimoto, Masumi Iijima, Hidenori Matsuo, Goro Matsuzaki, Shun'ichi Kuroda, Takeshi Arakawa

Microbiology and Immunology　Vol. 57　No. 6　p. 470-477　2013/06　Research paper (scientific journal)

Bio-Nanocapsules for Signal Enhancement of Alkaline Phosphatase-Linked Immunosorbent Assays

Masumi IIJIMA, Mikako YAMAMOTO, Nobuo YOSHIMOTO, Tomoaki NIIMI, Shun'ichi KURODA

Bioscience, Biotechnology, and Biochemistry　Vol. 77　No. 4　p. 843-846　2013/04/23　Research paper (scientific journal)

Application of Bionanocapsule-liposome complex for in vivo pinpoint drug delivery

Vol. 42　No. 4　p. 44-49　2013/04

Cell Surface-Fluorescence Immunosorbent Assay for Real-Time Detection of Hybridomas with Efficient Antibody Secretion at the Single-Cell Level

Akiko Kida, Masumi Iijima, Tomoaki Niimi, Andrés D. Maturana, Nobuo Yoshimoto, Shun’ichi Kuroda

Analytical Chemistry　Vol. 85　No. 3　p. 1753-1759　2013/02/05　Research paper (scientific journal)

An automated system for high-throughput single cell-based breeding

Nobuo Yoshimoto, Akiko Kida, Xu Jie, Masaya Kurokawa, Masumi Iijima, Tomoaki Niimi, Andres D. Maturana, Itoshi Nikaido, Hiroki R. Ueda, Kenji Tatematsu, Katsuyuki Tanizawa, Akihiko Kondo, Ikuo Fujii, Shun'ichi Kuroda

SCIENTIFIC REPORTS　Vol. 3　p. 1191-1199　2013/02　Research paper (scientific journal)

オール名古屋大学の純米酒「なごみ桜」

黒田俊一

日本醸造協会誌　Vol. 108　No. 5　p. 352-353　2013

バイオナノカプセルを用いるイムノセンシング分子の整列化技術

飯嶋益巳, 黒田俊一

バイオサイエンスとバイオインダストリー　Vol. 71　p. 314-317　2013

バイオナノカプセルを用いた生体内ピンポイントDDS技術の開発

松尾英典, 良元伸男, 黒田俊一

表面　Vol. 50　No. 6　p. 207-218　2013

Nanocapsule-based probe for evaluating the orientation of antibodies immobilized on a solid phase

ijima M, Yoshimoto N, Niimi T, Kuroda S

Analyst　Vol. 138　p. 3470-3477　2013

Nano-visualization of oriented-immobilized IgGs on immunosensors by high-speed atomic force microscopy

Masumi Iijima, Masaharu Somiya, Nobuo Yoshimoto, Tomoaki Niimi, Shun'ichi Kuroda

Scientific Reports　Vol. 2　No. 1　p. 790-790　2012/12　Research paper (scientific journal)

NELL-1 promotes cell adhesion and differentiation via integrinβ1

Jia Shen, Aaron W. James, Jonguk Chung, Kiho Lee, James B. Zhang, Stephanie Ho, Kevin S. Lee, Toyong M. Kim, Tomoaki Niimi, Shun'ichi Kuroda, Kang Ting, Chia Soo

Journal of Cellular Biochemistry　Vol. 113　No. 12　p. 3620-3628　2012/12　Research paper (scientific journal)

The role of PKC isoforms in the inhibition of NF-κB activation by vitamin K2 in human hepatocellular carcinoma cells

JingHe Xia, Sachiko Matsuhashi, Hiroshi Hamajima, Shinji Iwane, Hirokazu Takahashi, Yuichiro Eguchi, Toshihiko Mizuta, Kazuma Fujimoto, Shun'ichi Kuroda, Iwata Ozaki

The Journal of Nutritional Biochemistry　Vol. 23　No. 12　p. 1668-1675　2012/12　Research paper (scientific journal)

Development of Bio-Nanocapsules (Nanocarriers Possessing Viral Infection Machinery) for in vivo Pinpoint DDS Carrier

KURODA Shun'ichi

Vol. 61　No. 8　p. 530-532　2012/08

The C-terminal region of NELL1 mediates osteoblastic cell adhesion through integrin alpha 3 beta 1

Ai Hasebe, Yoko Nakamura, Hiroki Tashima, Kaneyoshi Takahashi, Masumi Iijima, Nobuo Yoshimoto, Kang Ting, Shun'ichi Kuroda, Tomoaki Niimi

FEBS LETTERS　Vol. 586　No. 16　p. 2500-2506　2012/07　Research paper (scientific journal)

Targeting of polyplex to human hepatic cells by bio-nanocapsules, hepatitis B virus surface antigen L protein particles

Masaharu Somiya, Nobuo Yoshimoto, Masumi Iijima, Tomoaki Niimi, Takehisa Dewa, Joohee Jung, Shun’ichi Kuroda

Bioorganic & Medicinal Chemistry　Vol. 20　No. 12　p. 3873-3879　2012/06　Research paper (scientific journal)

Hepatitis B virus envelope L protein-derived bio-nanocapsules: Mechanisms of cellular attachment and entry into human hepatic cells

Mitsuo Yamada, Ayako Oeda, Joohee Jung, Masumi Iijima, Nobuo Yoshimoto, Tomoaki Niimi, Seong-Yun Jeong, Eun Kyung Choi, Katsuyuki Tanizawa, Shun'ichi Kuroda

Journal of Controlled Release　Vol. 160　No. 2　p. 322-329　2012/06　Research paper (scientific journal)

Cell Wall Trapping of Autocrine Peptides for Human G-Protein-Coupled Receptors on the Yeast Cell Surface

Jun Ishii, Nobuo Yoshimoto, Kenji Tatematsu, Shun’ichi Kuroda, Chiaki Ogino, Hideki Fukuda, Akihiko Kondo

PLoS ONE　Vol. 7　No. 5　p. e37136-e37136　2012/05/18　Research paper (scientific journal)

Targeted sonodynamic therapy using protein-modified TiO2 nanoparticles

Kazuaki Ninomiya, Chiaki Ogino, Shuhei Oshima, Shiro Sonoke, Shun-ichi Kuroda, Nobuaki Shimizu

ULTRASONICS SONOCHEMISTRY　Vol. 19　No. 3　p. 607-614　2012/05　Research paper (scientific journal)

An Unusual Subtilisin-like Serine Protease Is Essential for Biogenesis of Quinohemoprotein Amine Dehydrogenase

Tadashi Nakai, Kazutoshi Ono, Shun'ichi Kuroda, Katsuyuki Tanizawa, Toshihide Okajima

Journal of Biological Chemistry　Vol. 287　No. 9　p. 6530-6538　2012/02/24　Research paper (scientific journal)

Engineered hepatitis B virus surface antigen L protein particles for in vivo active targeting of splenic dendritic cells

Hidenori Matsuo, Nobuo Yoshimoto, Masumi Iijima, Tomoaki Niimi, Joohee Jung, Seong-Yun Jeong, Eun Kyung Choi, Tomomitsu Sewaki, Takeshi Arakawa, Shun'ichi Kuroda

INTERNATIONAL JOURNAL OF NANOMEDICINE　Vol. 7　p. 3341-3350　2012　Research paper (scientific journal)

Fluorophore-labeled nanocapsules displaying IgG Fc-binding domains for the simultaneous detection of multiple antigens

Masumi Iijima, Takashi Matsuzaki, Nobuo Yoshimoto, Tomoaki Niimi, Katsuyuki Tanizawa, Shun’ichi Kuroda

Biomaterials　Vol. 32　No. 34　p. 9011-9020　2011/12　Research paper (scientific journal)

「名大さくら酵母」 学内資源を活用して造るオール名古屋大学の純米酒

黒田俊一

日本生物工学会誌　Vol. 89　No. 10　p. 111-625　2011/10

Hepatoma-targeted gene delivery using a tumor cell-specific gene regulation system combined with a human liver cell-specific bionanocapsule (vol 6, pg 583, 2010)

Jeong-Hun Kang, Jun Oishi, Jong-Hwan Kim, Moeko Ijuin, Riki Toita, Byungdug Jun, Daisuke Asai, Takeshi Mori, Takuro Niidome, Katsuyuki Tanizawa, Shun'ichi Kuroda, Yoshiki Katayama

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE　Vol. 7　No. 4　p. 514-514　2011/08

Efficient and rapid purification of drug- and gene-carrying bio-nanocapsules, hepatitis B virus surface antigen L particles, from Saccharomyces cerevisiae

Joohee Jung, Masumi Iijima, Nobuo Yoshimoto, Mano Sasaki, Tomoaki Niimi, Kenji Tatematsu, Seong-Yun Jeong, Eun Kyung Choi, Katsuyuki Tanizawa, Shun’ichi Kuroda

Protein Expression and Purification　Vol. 78　No. 2　p. 149-155　2011/08　Research paper (scientific journal)

LIM domains regulate protein kinase C activity: A novel molecular function

Andrés D. Maturana, Noritaka Nakagawa, Nobuo Yoshimoto, Kenji Tatematsu, Masahiko Hoshijima, Katsuyuki Tanizawa, Shun'ichi Kuroda

Cellular Signalling　Vol. 23　No. 5　p. 928-934　2011/05　Research paper (scientific journal)

Nell-1, a key functional mediator of Runx2, partially rescues calvarial defects in Runx2+/- mice

Xinli Zhang, Kang Ting, Catherine M. Bessette, Cymbeline T. Culiat, Sang Jin Sung, Haofu Lee, Feng Chen, Jia Shen, James J. Wang, Shun'Ichi Kuroda, Chia Soo

Journal of Bone and Mineral Research　Vol. 26　No. 4　p. 777-791　2011/04　Research paper (scientific journal)

Nanocapsules incorporating IgG Fc-binding domain derived from Staphylococcus aureus protein A for displaying IgGs on immunosensor chips

Masumi Iijima, Hiroyasu Kadoya, Satoko Hatahira, Shingo Hiramatsu, Giman Jung, Aaron Martin, John Quinn, Joohee Jung, Seong-Yun Jeong, Eun Kyung Choi, Takeshi Arakawa, Fumiyo Hinako, Masanobu Kusunoki, Nobuo Yoshimoto, Tomoaki Niimi, Katsuyuki Tanizawa, Shun&apos, ichi Kuroda

BIOMATERIALS　Vol. 32　No. 6　p. 1455-1464　2011/02　Research paper (scientific journal)

S28. Targeted sonodynamic therapy using protein-modified TiO_2 nanoparticles(Oral Presentation)

Ninomiya Kazuaki, Oshima Shuhei, Sonoke Shiro, Ogino Chiaki, Kuroda Shun-ichi, Shimizu Nobuaki

Proceedings of the Annual Meeting of the Japan Society of Sonochemistry　Vol. 20　p. 80-83　2011

Efficient Production and Characterization of Recombinant Human NELL1 Protein in Human Embryonic Kidney 293-F Cells

Ai Hasebe, Hiroki Tashima, Teruhiko Ide, Masumi Iijima, Nobuo Yoshimoto, Kang Ting, Shun'ichi Kuroda, Tomoaki Niimi

MOLECULAR BIOTECHNOLOGY　Vol. 51　No. 1　p. 58-66　2011　Research paper (scientific journal)

Development of automated single-cell isolation and analysis system

Yoshimoto Nobuo, Xu Jie, Kurokawa Masaya, Kondo Akihiko, Fujii Ikuo, Kuroda Shun'ichi

Vol. 89　No. 2　p. 72-78　2011/01

Human Liver Specific Nano-Carrier in a Novel Mouse Xenograft Model Bearing Non-Cancerous Human Liver Tissue

Matsuura Y, Yagi H, Matsuda S, Itano O, Koichi A, Kuroda S, Ueda M, Kitagawa Y

European Surgical Research　Vol. 46　p. 65-72　2011

Construction of protein-modified TiO2 nanoparticles for use with ultrasound irradiation in a novel cell injuring method

Chiaki Ogino, Naonori Shibata, Ryosuke Sasai, Keiko Takaki, Yusuke Miyachi, Shun-ichi Kuroda, Kazuaki Ninomiya, Nobuaki Shimizu

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS　Vol. 20　No. 17　p. 5320-5325　2010/09　Research paper (scientific journal)

A gene-delivery system specific for hepatoma cells and an intracellular kinase signal based on human liver-specific bionanocapsules and signal-responsive artificial polymer

Jun Oishi, Joohee Jung, Akira Tsuchiya, Riki Toita, Jeong-Hun Kang, Takeshi Mori, Takuro Niidome, Katsuyuki Tanizawa, Shun’ichi Kuroda, Yoshiki Katayama

International Journal of Pharmaceutics　Vol. 396　No. 1-2　p. 174-178　2010/08/30　Research paper (scientific journal)

Hepatoma-targeted gene delivery using a tumor cell–specific gene regulation system combined with a human liver cell–specific bionanocapsule

Jeong-Hun Kang, Jun Oishi, Jong-Hwan Kim, Moeko Ijuin, Riki Toita, Byungdug Jun, Daisuke Asai, Takeshi Mori, Takuro Niidome, Katsuyuki Tanizawa, Shun'ichi Kuroda, Yoshiki Katayama

Nanomedicine: Nanotechnology, Biology and Medicine　Vol. 6　No. 4　p. 583-589　2010/08　Research paper (scientific journal)

Splice variants of Enigma homolog, differentially expressed during heart development, promote or prevent hypertrophy

Tomoko Yamazaki, Sebastien Walchli, Toshitsugu Fujita, Stephan Ryser, Masahiko Hoshijima, Werner Schlegel, Shun'ichi Kuroda, Andres D. Maturana

CARDIOVASCULAR RESEARCH　Vol. 86　No. 3　p. 374-382　2010/06　Research paper (scientific journal)

1分子1細胞アッセイ技術に基づく生物工学の最近の潮流

黒田俊一, 藤井郁夫, 近藤昭彦

生物工学会誌　Vol. 88　No. 12　p. 671-671　2010

Functions of Fasciculation and Elongation Protein Zeta-1 (FEZ1) in the Brain

Andres D. Maturana, Toshitsugu Fujita, Shun'ichi Kuroda

THESCIENTIFICWORLDJOURNAL　Vol. 10　p. 1646-1654　2010　Research paper (scientific journal)

Bionanocapsule-based enzyme–antibody conjugates for enzyme-linked immunosorbent assay

Masumi Iijima, Takashi Matsuzaki, Hiroyasu Kadoya, Satoko Hatahira, Shingo Hiramatsu, Giman Jung, Katsuyuki Tanizawa, Shun’ichi Kuroda

Analytical Biochemistry　Vol. 396　No. 2　p. 257-261　2010/01　Research paper (scientific journal)

Accumulation of polyubiquitinated proteins by overexpression of RBCC protein interacting with protein kinase C2, a splice variant of ubiquitin ligase RBCC protein interacting with protein kinase C1

Nobuo Yoshimoto, Kenji Tatematsu, Toshihide Okajima, Katsuyuki Tanizawa, Shun’ichi Kuroda

FEBS Journal　Vol. 276　No. 21　p. 6375-6385　2009/11　Research paper (scientific journal)

Role of the T-Type Calcium Channel Ca(V)3.2 in the Chronotropic Action of Corticosteroids in Isolated Rat Ventricular Myocytes

Andres Maturana, Sebastien Lenglet, Magaly Python, Shun'Ichi Kuroda, Michel F. Rossier

ENDOCRINOLOGY　Vol. 150　No. 8　p. 3726-3734　2009/08　Research paper (scientific journal)

A03 In vitro and in vivo evaluation of sonocatalytic cancer therapy coupled with TiO_2 nanoparticles

OSHIMA Shuhei, NINOMIYA Kazuaki, OGINO Chiaki, KURODA Shunichi, SHIMIZU Nobuaki

Proceedings of the Annual Meeting of the Japan Society of Sonochemistry　Vol. 18　p. 5-6　2009

TiO&2&ナノ粒子と超音波を併用した新規がん治療法構築のための基礎的検討

仁宮 一章, 園家 史朗, 大島 周平, 荻野 千秋, 黒田 俊一, 清水 宣明

化学工学会 研究発表講演要旨集　Vol. 2009　p. 728-728　2009

BIO-NANOCAPSULE-LIPOSOME CONJUGATES FOR IN VIVO PINPOINT DRUG AND GENE DELIVERY

Takeshi Kasuya, Joohee Jung, Rie Kinoshita, Yasumasa Goh, Takashi Matsuzaki, Masumi Iijima, Nobuo Yoshimoto, Katsuyuki Tanizawa, Shun'ichi Kuroda

METHODS IN ENZYMOLOGY; LIPOSOMES, PT F　Vol. 464　p. 147-166　2009　Part of collection (book)

Targeted nanoparticle drug delivery systems to the human liver: in vitro and in vivo advances

Kasuya, T, Yamada, T, Kuroda, S

Expert Opinion on Drug Delivery　Vol. 6　p. 1-14　2009

The potentiality of DDS in uveitis treatment

Vol. 51　No. 7　p. 891-899　2009

Human eosinophil cationic protein enhances stress fiber formation in Balb/c 3T3 fibroblasts and differentiation of rat neonatal cardiomyocytes

Takayuki Fukuda, Miki Iwata, Midori Kitazoe, Takashi Maeda, David Salomon, Satoshi Hirohata, Katsuyuki Tanizawa, Shun'ichi Kuroda, Masaharu Seno

Growth Factors　Vol. 27　No. 4　p. 228-236　2009/01　Research paper (scientific journal)

Expression of squamous cell carcinoma antigen-1 in liver enhances the uptake of hepatitis B virus envelope-derived bio-nanocapsules in transgenic rats

Takeshi Kasuya, Shintaro Nomura, Takashi Matsuzaki, Joohee Jung, Tadanori Yamada, Kenji Tatematsu, Toshihide Okajima, Katsuyuki Tanizawa, Shun'ichi Kuroda

FEBS Journal　Vol. 275　No. 22　p. 5714-5724　2008/11　Research paper (scientific journal)

In VivoDelivery of Bionanocapsules DisplayingPhaseolus vulgarisAgglutinin-L4Isolectin to Malignant Tumors OverexpressingN-Acetylglucosaminyltransferase V

Takeshi Kasuya, Joohee Jung, Hiroyasu Kadoya, Takashi Matsuzaki, Kenji Tatematsu, Toshihide Okajima, Eiji Miyoshi, Katsuyuki Tanizawa, Shun'ichi Kuroda

Human Gene Therapy　Vol. 19　No. 9　p. 887-895　2008/09　Research paper (scientific journal)

In vivo protein delivery to human liver-derived cells using hepatitis B virus envelope pre-S region

Takeshi Kasuya, Tadanori Yamada, Atsuko Uyeda, Takashi Matsuzaki, Toshihide Okajima, Kenji Tatematsu, Katsuyuki Tanizawa, Shun'Ichi Kuroda

Journal of Bioscience and Bioengineering　Vol. 106　No. 1　p. 99-102　2008/07　Research paper (scientific journal)

Enigma homolog 1 scaffolds protein kinase D1 to regulate the activity of the cardiac L-type voltage-gated calcium channel

Andres D. Maturana, Sebastien Waelchli, Miki Iwata, Stephan Ryser, Johannes Van Lint, Masahiko Hoshijima, Werner Schlegel, Yasuhiro Ikeda, Katsuyuki Tanizawa, Shun'ichi Kuroda

CARDIOVASCULAR RESEARCH　Vol. 78　No. 3　p. 458-465　2008/06　Research paper (scientific journal)

Crystal structures of Lymnaea stagnalis AChBP in complex with neonicotinoid insecticides imidacloprid and clothianidin

Makoto Ihara, Toshihide Okajima, Atsuko Yamashita, Takuma Oda, Koichi Hirata, Hisashi Nishiwaki, Takako Morimoto, Miki Akamatsu, Yuji Ashikawa, Shun'Ichi Kuroda, Ryosuke Mega, Seiki Kuramitsu, David B. Sattelle, Kazuhiko Matsuda

Invertebrate Neuroscience　Vol. 8　No. 2　p. 71-81　2008/06　Research paper (scientific journal)

Yeast-based fluorescence reporter assay of G protein-coupled receptor signalling for flow cytometric screening: FAR1-disruption recovers loss of episomal plasmid caused by signalling in yeast.

Jun Ishii, Tsutomu Tanaka, Shizuka Matsumura, Kenji Tatematsu, Shun'ichi Kuroda, Chiaki Ogino, Hideki Fukuda, Akihiko Kondo

Journal of biochemistry　Vol. 143　No. 5　p. 667-674　2008/05　Research paper (scientific journal)

Identification of ubiquitin ligase activity of RBCK1 and its inhibition by splice variant RBCK2 and protein kinase C beta

Kenji Tatematsu, Nobuo Yoshimoto, Toshihide Okajima, Katsuyuki Tanizawa, Shun'ichi Kuroda

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 283　No. 17　p. 11575-11585　2008/04　Research paper (scientific journal)

Bio-nanocapsule conjugated with liposomes for in vivo pinpoint delivery of various materials

Joohee Jung, Takashi Matsuzaki, Kenji Tatematsu, Toshihide Okajima, Katsuyuki Tanizawa, Shun'ichi Kuroda

JOURNAL OF CONTROLLED RELEASE　Vol. 126　No. 3　p. 255-264　2008/03　Research paper (scientific journal)

酵母蛍光レポーターアッセイによるヒトソマトスタチンレセプター変異体の機能解析

戸川 翔太, 石井 純, 田中 勉, 立松 健司, 黒田 俊一, 福田 秀樹, 近藤 昭彦

化学工学会 研究発表講演要旨集　Vol. 2008　p. 971-971　2008

酵母でのヒトG蛋白質共役型受容体発現に関する分泌シグナル配列の影響

井口 裕介, 石井 純, 田中 勉, 立松 健司, 黒田 俊一, 福田 秀樹, 近藤 昭彦

化学工学会 研究発表講演要旨集　Vol. 2008　p. 970-970　2008

P28 Evaluation of sonocatalytic cytotoxicity of cancer cells with incorporation of TiO_2 nanoparticles(Part II,Poster session)

NINOMIYA Kazuaki, SONOKE Shiro, OSHIMA Shuhei, OGINO Chiaki, KURODA Shun'ichi, SHIMIZU Nobuaki

Proceedings of the Annual Meeting of the Japan Society of Sonochemistry　Vol. 17　p. 96-97　2008

フローサイトメーター(FCM)を利用した酵母GPCRシグナリング解析技術

石井 純, 田中 勉, 松村 静香, 立松 健司, 黒田 俊一, 荻野 千秋, 福田 秀樹, 近藤 昭彦

化学工学会 研究発表講演要旨集　Vol. 2008　p. 348-348　2008

抗体提示バイオナノカプセルを用いたピンポイントプロテインデリバリーシステムの開発

安住 友希, 倉田 直弥, 宍戸 卓矢, 上田 政和, 妹尾 昌治, 多田 宏子, 谷澤 克行, 黒田 俊一, 田中 勉, 福田 秀樹, 近藤 昭彦

化学工学会 研究発表講演要旨集　Vol. 2008　p. 320-320　2008

機能性二酸化チタン・ナノ粒子のがん治療への基礎研究

笹井 良祐, 園家 史朗, 大島 周平, 荻野 千秋, 黒田 俊一, 清水 宣明

化学工学会 研究発表講演要旨集　Vol. 2008　p. 328-328　2008

The mitogen-activated protein kinase p38 links Shiga toxin-dependent signaling and trafficking

Sebastien Walchli, Sigrid S. Skanland, Tone F. Gregers, Silje U. Lauvrak, Maria L. Torgersen, Ming Ying, Shun'ichi Kuroda, Andres Maturana, Kirsten Sandvig

MOLECULAR BIOLOGY OF THE CELL　Vol. 19　No. 1　p. 95-104　2008/01　Research paper (scientific journal)

Involvement of MAPK signaling molecules and Runx2 in the NELL1-induced osteoblastic differentiation

Nobuyuki Bokui, Takayuki Otani, Koichi Igarashi, Junichiro Kaku, Mitsuo Oda, Tadahiro Nagaoka, Masaharu Seno, Kenji Taternatsu, Toshihide Okajima, Takashi Matsuzaki, Kang Ting, Katsuyuki Tanizawa, Shunichi Kuroda

FEBS LETTERS　Vol. 582　No. 2　p. 365-371　2008/01　Research paper (scientific journal)

Axonal guidance protein FEZ1 associates with tubulin and kinesin motor protein to transport mitochondria in neurites of NGF-stimulated PC12 cells

Toshitsugu Ftijita, Andres D. Maturana, Junko Ikuta, Juri Hamada, Sebastien Walchli, Tadaki Suzuki, Hirofurni Sawa, Marie W. Wooten, Toshihide Okajima, Kenji Taternatsu, Katsuyuki Tanizawa, Shun'ichi Kuroda

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 361　No. 3　p. 605-610　2007/09　Research paper (scientific journal)

Synergistic effects of Nell-1 and BMP-2 on the osteogenic differentiation of myoblasts

Catherine M. Cowan, Xinquan Jiang, Tiffany Hsu, Chia Soo, Beiji Zhang, Joyce Z. Wang, Shun'ichi Kuroda, Benjamin Wu, Zhiyuan Zhang, Xinli Zhang, Kang Ting

JOURNAL OF BONE AND MINERAL RESEARCH　Vol. 22　No. 6　p. 918-930　2007/06　Research paper (scientific journal)

Gene therapy of liver tumors with human liver-specific nanoparticles (vol 14, pg 74, 2007)

M. Ueda, Y. Iwasaki, T. Yamada, A. Kondo, M. Seno, K. Tanizawa, S. Kuroda, M. Sakamoto, M. Kitajima

CANCER GENE THERAPY　Vol. 14　No. 4　p. 440-440　2007/04

Characterization of bio-nanocapsule as a transfer vector targeting human hepatocyte carcinoma by disulfide linkage modification

Tadahiro Nagaoka, Takayuki Fukuda, Shinnosuke Yoshida, Hirohito Nishimura, Dongwei Yu, Shun'ichi Kuroda, Katsuyuki Tanizawa, Akhko Kondo, Masakazu Ueda, Hidenori Yamada, Hiroko Tada, Masaharu Seno

JOURNAL OF CONTROLLED RELEASE　Vol. 118　No. 3　p. 348-356　2007/04　Research paper (scientific journal)

A cold-active and thermostable alcohol dehydrogenase of a psychrotorelant from Antarctic seawater, Flavobacterium frigidimaris KUC-1

Takayuki Kazuoka, Tadao Oikawa, Ikuo Muraoka, Shun'ichi Kuroda, Kenji Soda

EXTREMOPHILES　Vol. 11　No. 2　p. 257-267　2007/03　Research paper (scientific journal)

酵母を用いたリガンド検出システムの開発

森口 みゆき, 石井 純, 立松 健司, 黒田 俊一, 福田 秀樹, 近藤 昭彦

化学工学会 研究発表講演要旨集　Vol. 2007　p. 844-844　2007

S3-5 Construction of biomolecule-immobilized TiO_2 nanoparticle for applying to new cell injuring method with ultrasound irradiation(Symposium (3) Biomedical Application)

Ogino Chiaki, Sasai Ryousuke, Sonoke Shirou, Kuroda Shunichi, Shimizu Nobuaki

Proceedings of the Annual Meeting of the Japan Society of Sonochemistry　Vol. 2007　p. 50-51　2007

組織ターゲティング機能を有する二酸化チタンナノ粒子によるがん細胞障害

柴田 直範, 笹井 良祐, 高木 圭子, 黒田 俊一, 荻野 千秋, 清水 宣明

化学工学会 研究発表講演要旨集　Vol. 2007　p. 391-391　2007

Gene Therapy of Liver Tumors with Human Liver-Specific Nanoparticles

Iwasaki Y, Ueda M, Yamada T, Kondo A, Seno M, Tanizawa K, Kuroda S, Sakamoto M, Kitajima M

Cancer Gene Ther　Vol. 14　p. 74-81　2007

生体内ピンポイント投与を可能にするバイオナノカプセル

鄭周姫, 粕谷武司, 谷澤克行, 黒田俊一

日本薬学会誌　Vol. 128　p. 797-805　2007

バイオナノキャリアの開発とがん遺伝子治療への応用

近藤昭彦, 黒田俊一, 谷澤克行, 妹尾昌治, 上田政和

バイオテクノロジージャーナル　Vol. 7　No. 1　p. 41-47　2007

Fasciculation and elongation protein zeta-1 (FEZ1) participates in the polarization of hippocampal neuron by controlling the mitochondrial motility

Ikuta, J, Maturana, A, Fujita, T, Okajima, T, Tatematsu, K, Tanizawa, K, Kuroda, S

Biochem. Biophys. Res. Commun　Vol. 353　p. 127-132　2007

Secretory production system of bionanocapsules using a stably transfected insect cell line

Takuya Shishido, Masaru Muraoka, Masakazu Ueda, Masaharu Seno, Katsuyuki Tanizawa, Shun'ichi Kuroda, Hideki Fukuda, Akihiko Kondo

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY　Vol. 73　No. 3　p. 505-511　2006/12　Research paper (scientific journal)

Nell-1-induced bone regeneration in calvarial defects

Tara Aghaloo, Catherine M. Cowan, Yu-Fen Chou, Xinli Zhang, Haoful Lee, Steve Miao, Nichole Hong, Shun'ichi Kuroda, Benjamin Wu, Kang Ting, Chia Soo

AMERICAN JOURNAL OF PATHOLOGY　Vol. 169　No. 3　p. 903-915　2006/09　Research paper (scientific journal)

Quantitative and dynamic analyses of G protein-coupled receptor signaling in yeast using FUS1, enhanced green fluorescence protein (EGFP), and HIS3 fusion protein

Jun Ishii, Shizuka Matsumura, Sakurako Kimura, Kenji Tatematsu, Shun'ichi Kuroda, Hideki Fukuda, Akihiko Kondo

BIOTECHNOLOGY PROGRESS　Vol. 22　No. 4　p. 954-960　2006/08　Research paper (scientific journal)

Nell-1 induces acrania-like cranioskeletal deformities during mouse embryonic development

XL Zhang, CM Cowan, XQ Jiang, C Soo, S Miao, D Carpenter, B Wu, S Kuroda, K Ting

LABORATORY INVESTIGATION　Vol. 86　No. 7　p. 633-644　2006/07　Research paper (scientific journal)

Involvement of a putative [Fe-S]-cluster-binding protein in the biogenesis of quinohemoprotein amine dehydrogenase

K Ono, T Okajima, M Tani, S Kuroda, D Sun, VL Davidson, K Tanizawa

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 281　No. 19　p. 13672-13684　2006/05　Research paper (scientific journal)

Quantum mechanical hydrogen tunneling in bacterial copper amine oxidase reaction

T Murakawa, T Okajima, S Kuroda, T Nakamoto, M Taki, Y Yamamoto, H Hayashi, K Tanizawa

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 342　No. 2　p. 414-423　2006/04　Research paper (scientific journal)

Kinetic and structural studies on the catalytic role of the aspartic acid residue conserved in copper amine oxidase

YC Chiu, T Okajima, T Murakawa, M Uchida, M Taki, S Hirota, M Kim, H Yamaguchi, Y Kawano, N Kamiya, S Kuroda, H Hayashi, Y Yamamoto, K Tanizawa

BIOCHEMISTRY　Vol. 45　No. 13　p. 4105-4120　2006/04　Research paper (scientific journal)

Development of dds using hollow bio-nanoparticles and their commercialization

Akihiko Kondo, Shun-ichi Kuroda, Katsuyuki Tanizawa, Masaharu Seno, Masakazu Ueda

Drug Delivery System　Vol. 21　No. 4　p. 435-443　2006　Research paper (scientific journal)

フェロモン応答性タンパク質を利用した新規レポーターによるリガンド検出システムの開発

森口 みゆき, 石井 純, 立松 健司, 黒田 俊一, 福田 秀樹, 近藤 昭彦

化学工学会 研究発表講演要旨集　Vol. 2006　p. 986-986　2006

Nell-1 induced bone formation within the distracted intermaxillary suture

CM Cowan, S Cheng, K Ting, C Soo, B Walder, B Wu, S Kuroda, XL Zhang

BONE　Vol. 38　No. 1　p. 48-58　2006/01　Research paper (scientific journal)

バイオナノカプセルの開発と医薬品分野での応用

黒田俊一

PHARM STAGE　Vol. 6　No. 8　p. 61-69　2006

中空バイオナノ粒子を用いたDDS の開発とその産業化

近藤昭彦, 黒田俊一, 谷澤克行, 妹尾昌治, 上田政和

Drug Delivery System　Vol. 21　No. 4　p. 435-443　2006

Engineered bio-nanocapsules, the selective vector for drug delivery system

DW Yu, T Fukuda, Tuoya, S Kuroda, K Tanizawa, A Kondo, M Ueda, T Yamada, H Tada, M Seno

IUBMB LIFE　Vol. 58　No. 1　p. 1-6　2006/01

バイオナノカプセルの開発とバイオメディカル分野での応用

黒田俊一, 粕谷武史, 鄭周姫, 谷澤克行

化学工業　Vol. 57　No. 11　p. 869-874　2006

乳酸菌表層ディスプレイ技術による新しいHPVワクチンの創製

瀬脇智満, 夫 夏玲, 金 哲仲, 成 文喜, 黒田俊一

細胞　Vol. 38　No. 13　p. 36-39　2006

遺伝子・薬剤の生体内ピンポイントデリバリーを可能にするバイオナノカプセルの現状とこれから

粕谷武司, 鄭 周姫, 谷澤克行, 黒田俊一

化学と生物　Vol. 44　No. 11　p. 760-766　2006

Cytoplasmic tethering of a RING protein RBCK1 by its splice variant lacking the RING domain

Nobuo Yoshimoto, Kenji Tatematsu, Tomoyoshi Koyanagi, Toshihide Okajima, Katsuyuki Tanizawa, Shun’ichi Kuroda

Biochemical and Biophysical Research Communications　Vol. 335　No. 2　p. 550-557　2005/09　Research paper (scientific journal)

Reinvestigation of metal ion specificity for quinone cofactor biogenesis in bacterial copper amine oxidase

T Okajima, S Kishishita, YC Chiu, T Murakawa, M Kim, H Yamaguchi, S Hirota, S Kuroda, K Tanizawa

BIOCHEMISTRY　Vol. 44　No. 36　p. 12041-12048　2005/09　Research paper (scientific journal)

Spatial learning of mice lacking a neuron-specific epidermal growth factor family protein, NELL2

S Matsuyama, N Doe, N Kurihara, K Tanizawa, S Kuroda, H Iso, M Horie

JOURNAL OF PHARMACOLOGICAL SCIENCES　Vol. 98　No. 3　p. 239-243　2005/07　Research paper (scientific journal)

The specific delivery of proteins to human liver cells by engineered bio-nanocapsules

DW Yu, C Amano, T Fukuda, T Yamada, S Kuroda, K Tanizawa, A Kondo, M Ueda, H Yamada, H Tada, M Seno

FEBS JOURNAL　Vol. 272　No. 14　p. 3651-3660　2005/07　Research paper (scientific journal)

Identification of FEZ1 as a protein that interacts with JC virus agnoprotein and microtubules - Role of agnoprotein-induced dissociation of FEZ1 from microtubules in viral propagation

T Suzuki, Y Okada, S Semba, S Orba, Yamanouchi, S Endo, S Tanaka, T Fujita, S Kuroda, K Nagashima, H Sawa

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 280　No. 26　p. 24948-24956　2005/07　Research paper (scientific journal)

Nuclear-Cytoplasmic Shuttling of a RING-IBR Protein RBCK1 and Its Functional Interaction with Nuclear Body Proteins

Kenji Tatematsu, Nobuo Yoshimoto, Tomoyoshi Koyanagi, Chiharu Tokunaga, Taro Tachibana, Yoshihiro Yoneda, Minoru Yoshida, Toshihide Okajima, Katsuyuki Tanizawa, Shun'ichi Kuroda

Journal of Biological Chemistry　Vol. 280　No. 24　p. 22937-22944　2005/06/17　Research paper (scientific journal)

PKC epsilon-PKD1 signaling complex at Z-discs plays a pivotal role in the cardiac hypertrophy induced by G-protein coupling receptor agonists

M Iwata, A Maturana, M Hoshijima, K Tatematsu, T Okajima, Vandenheede, JR, J Van Lint, K Tanizawa, S Kuroda

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 327　No. 4　p. 1105-1113　2005/02　Research paper (scientific journal)

昆虫細胞を用いたバイオナノ粒子の効率的生産

宍戸 卓矢, 村岡 優, 上田 政和, 妹尾 昌治, 多田 宏子, 谷澤 克行, 黒田 俊一, 福田 秀樹, 近藤 昭彦

化学工学会 研究発表講演要旨集　Vol. 2005　p. 327-327　2005

産学官連携によるバイオベンチャー設立まで----大学教官とバイオベンチャー取締役の両立を目指して----

黒田俊一

産学官連携ジャーナル　Vol. 1　No. 6　p. 25-28　2005

バイオベンチャー起業物語「ビークル」

黒田俊一

月刊「バイオインダストリー」　Vol. 22　No. 4　p. 88-95　2005

バイオナノカプセルの開発と化粧品への応用

黒田俊一

ＦＲＡＧＲＡＮＣＥ ＪＯＵＲＮＡＬ　Vol. 11　No. 11　p. 22-28　2005

バイオナノカプセルが拓く新しい医療技術

黒田俊一

バイオサイエンスとインダストリー　Vol. 63　No. 9　p. 589-590　2005

細胞及び組織特異的遺伝子導入を可能にするバイオナノカプセル

山田忠範, 妹尾昌治, 上田政和, 近藤昭彦, 谷澤克行, 黒田俊一

生物工学会会誌　Vol. 83　No. 8　p. 380-383　2005

中空バイオナノ粒子を用いたピンポイントDDSの開発

近藤昭彦, 黒田俊一, 谷澤克行, 妹尾昌治, 上田政和

月刊「ケミカル・エンジニヤリング」　Vol. 50　No. 5　p. 23-28　2005

革新的なナノキャリア：中空バイオナノ粒子によるピンポイントDDS

近藤昭彦, 黒田俊一, 谷澤克行, 妹尾昌治, 上田政和

月刊「バイオインダストリー」　Vol. 22　No. 5　p. 22-27　2005

ナノテクが導く「効果的な遺伝子治療」

鄭周姫, 黒田俊一

月刊「化学」　Vol. 60　No. 1　p. 23-25　2005

Over-expression system for secretory phospholipase D by Streptomyces lividans

C. Ogino, M. Kanemasu, Y. Hayashi, A. Kondo, N. Shimizu, S. Tokuyama, Y. Tahara, S. Kuroda, K. Tanizawa, H. Fukuda

Applied Microbiology and Biotechnology　Vol. 64　No. 6　p. 823-828　2004/06/01　Research paper (scientific journal)

Chemical rescue of a site-specific mutant of bacterial copper amine oxidase for generation of the topa quinone cofactor

H Matsunami, T Okajima, S Hirota, H Yamaguchi, H Hori, S Kuroda, K Tanizawa

BIOCHEMISTRY　Vol. 43　No. 8　p. 2178-2187　2004/03　Research paper (scientific journal)

Expression of fasciculation and elongation protein zeta-1 (FEZ1) in the developing rat brain

A Honda, K Miyoshi, K Baba, M Taniguchi, Y Koyama, S Kuroda, T Katayama, M Tohyama

MOLECULAR BRAIN RESEARCH　Vol. 122　No. 1　p. 89-92　2004/03　Research paper (scientific journal)

Enhanced Long-term Potentiation In Vivo in the Dentate Gyrus of Mice Lacking a Neuron-specific EGF Family Protein, NELL2

S Matsuyama, K Aihara, N Nishino, S Takeda, K Tanizawa, S Kuroda, M Horie

NEUROREPORT　Vol. 15　No. 3　p. 417-420　2004/03　Research paper (scientific journal)

Novel tissue and cell type-specific gene/drug delivery system using surface engineered hepatitis B virus nano-particles

Tadanori Yamada, Akihiko Kondo, Masakazu Ueda, Masaharu Seno, Katsuyuki Tanizawa, Shun'ichi Kuroda

Current Drug Targets - Infectious Disorders　Vol. 4　No. 2　p. 163-167　2004

Pinpoint drug delivery system using hollow bio-nanoparticles

T Yamada, M Seno, A Kondo, M Ueda, K Tanizawa, S Kuroda

KOBUNSHI RONBUNSHU　Vol. 61　No. 12　p. 606-612　2004　Research paper (scientific journal)

中空バイオナノ粒子が拓く新しい医療技術

黒田俊一, 妹尾昌治, 近藤昭彦, 上田政和, 谷澤克行

月刊「化学工業」　Vol. 55　No. 12　p. 40-46　2004

UNC-76/FEZ Family Is Essential for Axonal Guidance

Fujita, T, Ikuta, J, Maturana, A, Okajima, T, Tatematsu, K, Tanizawa, K, Kuroda, S

Recent Res. Devel. Biophys. Biochem.　Vol. 4　p. 313-320　2004

Identification of a tissue-non-specific homologue of axonal fasciculation and elongation protein zeta-1

Toshitsugu Fujita, Junko Ikuta, Juri Hamada, Toshihide Okajima, Kenji Tatematsu, Katsuyuki Tanizawa, Shun’ichi Kuroda

Biochemical and Biophysical Research Communications　Vol. 313　No. 3　p. 738-744　2004/01　Research paper (scientific journal)

Overexpression of Nell-1, a craniosynostosis-associated gene, induces apoptosis in osteoblasts during craniofacial development

XL Zhang, D Carpenter, N Bokui, C Soo, S Miao, T Truong, B Wu, Chen, I, H Vastardis, K Tanizawa, S Kuroda, K Ting

JOURNAL OF BONE AND MINERAL RESEARCH　Vol. 18　No. 12　p. 2126-2134　2003/12　Research paper (scientific journal)

Detection of protein-protein interactions onSiO(2)/Si surfaces by spectroscopic ellipsometry

S Kodera, T Okajima, H Iwabuki, D Kitaguchi, S Kuroda, T Yoshinobu, K Tanizawa, M Futai, H Iwasaki

ANALYTICAL BIOCHEMISTRY　Vol. 321　No. 1　p. 65-70　2003/10　Research paper (scientific journal)

Phospholipase D from Streptoverticillium cinnamoneum: protein engineering and application for phospholipid production

Chiaki Ogino, Shun’ichi Kuroda, Shinji Tokuyama, Akihiko Kondo, Nobuaki Shimizu, Katsuyuki Tanizawa, Hideki Fukuda

Journal of Molecular Catalysis B: Enzymatic　Vol. 23　No. 2-6　p. 107-115　2003/09　Research paper (scientific journal)

A neuron-specific EGF family protein, NELL2, promotes survival of neurons through mitogen-activated protein kinases

K Aihara, S Kuroda, N Kanayama, S Matsuyama, K Tanizawa, M Horie

MOLECULAR BRAIN RESEARCH　Vol. 116　No. 1-2　p. 86-93　2003/08　Research paper (scientific journal)

Nanoparticles for the delivery of genes and drugs to human hepatocytes

T Yamada, Y Iwasaki, H Tada, H Iwabuki, MKL Chuah, T VandenDriessche, H Fukuda, A Kondo, M Ueda, M Seno, K Tanizawa, S Kuroda

NATURE BIOTECHNOLOGY　Vol. 21　No. 8　p. 885-890　2003/08　Research paper (scientific journal)

A PKC epsilon-ENH-channel complex specifically modulates N-type Ca2+ channels

Y Maeno-Hikichi, SH Chang, K Matsumura, MZ Lai, H Lin, N Nakagawa, S Kuroda, JF Zhang

NATURE NEUROSCIENCE　Vol. 6　No. 5　p. 468-475　2003/05　Research paper (scientific journal)

Role of copper ion in bacterial copper amine oxidase: Spectroscopic and crystallographic studies of metal-substituted enzymes

Sei'ichiro Kishishita, Toshihide Okajima, Misa Kim, Hiroshi Yamaguchi, Shun Hirota, Shinnichiro Suzuki, Shun'ichi Kuroda, Katsuyuki Tanizawa, Minae Mure

Journal of the American Chemical Society　Vol. 125　No. 4　p. 1041-1055　2003/01/29　Research paper (scientific journal)

Disrupted-In-Schizophrenia 1, a candidate gene for schizophrenia, participates in axonal outgrowth

K Miyoshi, A Honda, K Baba, M Taniguchi, K Oono, T Fujita, S Kuroda, T Katayama, M Tohyama

MOLECULAR PSYCHIATRY　Vol. 8　No. 7　p. 685-694　2003　Research paper (scientific journal)

中空バイオナノ粒子によるピンポイントドラッグデリバリーシステム

Kondo, A, Kuroda, S, Tanizawa, K, Seno, M, Ueda, M

化学工学会誌　Vol. 67　No. 12　p. 686-688　2003

バイオナノ粒子を用いる遺伝子・薬剤のピンポイントでラッグデリバリーシステム

Seno, M, Kuroda, S, Kondo, A, Tada, H, Tanizawa, K, Ueda, M

BIO INDUSTRY　Vol. 4　p. 54-62　2003

Nanoparticle-directed Tissue-specific Delivery System for Genes and Drugs.

Kuroda, S, Yamada, T, Tanizawa, K

Discovery Medicine　Vol. 3　No. 18　p. 56-57　2003

Size distribution measurement of vesicles by atomic force microscopy

T Kanno, T Yamada, H Iwabuki, H Tanaka, S Kuroda, K Tanizawa, T Kawai

ANALYTICAL BIOCHEMISTRY　Vol. 309　No. 2　p. 196-199　2002/10　Research paper (scientific journal)

Craniosynostosis in transgenic mice overexpressing Nell-1

XL Zhang, S Kuroda, D Carpenter, Nishimura, I, C Soo, R Moats, K Iida, E Wisner, FY Hu, S Miao, S Beanes, C Dang, H Vastardis, M Longaker, K Tanizawa, N Kanayama, N Saito, K Ting

JOURNAL OF CLINICAL INVESTIGATION　Vol. 110　No. 6　p. 861-870　2002/09　Research paper (scientific journal)

HepG2細胞表面レセプター特異的抗体の機能的スクリーニング

北口 大輔, 岩蕗 秀彦, 山田 忠範, 立松 健司, 黒田 俊一, 岡島 俊英, 谷澤 克行

生化学　Vol. 74　No. 8　p. 946-946　2002/08

無血清培養により大量発現させた新規骨形成因子NELL1の生化学的解析

朴井 伸行, Ting Kang, 金山 範洋, 岩蕗 秀彦, 立松 健司, 岡島 俊英, 谷澤 克行, 黒田 俊一

生化学　Vol. 74　No. 8　p. 804-804　2002/08

RING-fingerを有する新規転写因子RPY1の低浸透圧下におけるMpk1との相互作用

八尾 修平, 小柳 智義, 立松 健司, 金子 嘉信, 原島 俊, 岡島 俊英, 谷澤 克行, 黒田 俊一

生化学　Vol. 74　No. 8　p. 926-926　2002/08

A brain-specific EGF-like family protein, NELL2, is a novel survival factor for neurons

K Aihara, M Horie, K Tanizawa, S Kuroda

NEUROBIOLOGY OF AGING　Vol. 23　No. 1　2002/07

Crystal structure of quinohemoprotein amine dehydrogenase from Pseudomonas putida - Identification of a novel quinone cofactor encaged by multiple thioether cross-bridges

A Satoh, JK Kim, Miyahara, I, B Devreese, Vandenberghe, I, A Hacisalihoglu, T Okajima, S Kuroda, O Adachi, JA Duine, J Van Beeumen, K Tanizawa, K Hirotsu

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 277　No. 4　p. 2830-2834　2002/01　Research paper (scientific journal)

Biogenesis Machinery of Peptide-Built-in Quinone Cofactors.

Okajima, T, Kuroda, S, Tanizawa, K

マテリアルインテグレーション　Vol. 15　No. 7　p. 23-27　2002

Novel Intracellular Biosignaling Machineries Involving Protein Kinase C-Interacting Proteins and Its Application.

Tatematsu, K, Okajima, T, Tanizawa, K, Kuroda, S

マテリアルインテグレーション　Vol. 15　No. 7　p. 18-22　2002

Development of Novel Gene Delivery System Using Bionanoparticles and Its Application for Advanced Medical Field.

Kuroda, S, Okajima, T, Tanizawa, K

マテリアルインテグレーション　Vol. 15　No. 7　p. 12-17　2002

Structure of a quinohemoprotein amine dehydrogenase with an uncommon redox cofactor and highly unusual crosslinking

S Datta, Y Mori, K Takagi, K Kawaguchi, ZW Chen, T Okajima, S Kuroda, T Ikeda, K Kano, K Tanizawa, FS Mathews

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　Vol. 98　No. 25　p. 14268-14273　2001/12　Research paper (scientific journal)

Brain specific human genes, NELL1 and NELL2, are predominantly expressed in neuroblastoma and other embryonal neuroepithelial tumors

K Maeda, S Matsuhashi, K Tabuchi, T Watanabe, T Katagiri, M Oyasu, N Saito, S Kuroda

NEUROLOGIA MEDICO-CHIRURGICA　Vol. 41　No. 12　p. 582-588　2001/12　Research paper (scientific journal)

The covalent structure of the small subunit from Pseudomonas putida amine dehydrogenase reveals the presence of three novel types of internal cross-linkages, all involving cysteine in a thioether bond

Vandenberghe, I, JK Kim, B Devreese, A Hacisalihoglu, H Iwabuki, T Okajima, S Kuroda, O Adachi, JA Jongejan, JA Duine, K Tanizawa, J Van Beeumen

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 276　No. 46　p. 42923-42931　2001/11　Research paper (scientific journal)

Novel intracellular signal transduction machineries mediated by protein kinase C-interacting proteins

S Kuroda

NIPPON NOGEIKAGAKU KAISHI-JOURNAL OF THE JAPAN SOCIETY FOR BIOSCIENCE BIOTECHNOLOGY AND AGROCHEMISTRY　Vol. 75　No. 11　p. 1191-1199　2001/11

【モチーフ・ドメインリスト】細胞接着 EGF様ドメイン

黒田 俊一, 立松 健司, 谷澤 克行

生体の科学　Vol. 52　No. 5　p. 462-463　2001/10

【モチーフ・ドメインリスト】遺伝子発現 転写及び関連事象 リングフィンガーモチーフ

黒田 俊一, 立松 健司, 谷澤 克行

生体の科学　Vol. 52　No. 5　p. 396-397　2001/10

心筋・骨格筋特異的PDZ-LIMタンパク質ENH1と相互作用するタンパク質の同定

岩田 美紀, 松村 清之, 中川 宣孝, 立松 健司, 岡島 俊英, 谷澤 克行, 黒田 俊一

生化学　Vol. 73　No. 8　p. 866-866　2001/08

Physicochemical and immunological characterization of hepatitis B virus envelope particles exclusively consisting of the entire L (pre-S1+pre-S2+S) protein

T Yamada, H Iwabuki, T Kanno, H Tanaka, T Kawai, H Fukuda, A Kondo, M Seno, K Tanizawa, S Kuroda

VACCINE　Vol. 19　No. 23-24　p. 3154-3163　2001/04　Research paper (scientific journal)

Sharpin, a novel postsynaptic density protein that directly interacts with the Shank family of proteins

S Lim, C Sala, JY Yoon, S Park, S Kuroda, M Sheng, E Kim

MOLECULAR AND CELLULAR NEUROSCIENCE　Vol. 17　No. 2　p. 385-397　2001/02　Research paper (scientific journal)

Identification of novel membrane-bound phospholipase D from Streptoverticillium cinnamoneum, possessing only hydrolytic activity

C Ogino, Y Negi, H Daido, M Kanemasu, A Kondo, S Kuroda, K Tanizawa, N Shimizu, H Fukuda

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS　Vol. 1530　No. 1　p. 23-31　2001/01　Research paper (scientific journal)

RING Finger Motif.

Kuroda, S, Tatematsu, K, Tanizawa, K

生体の化学　Vol. 52　p. 396-397　2001

EGF-Like Domain.

Kuroda, S, Tatematsu, K, Tanizawa, K

生体の化学　Vol. 52　p. 462-463　2001

Identification and characterization of PRKCBP1, a candidate RACK-like protein

SC Fossey, S Kuroda, JA Price, JC Pendleton, BI Freedman, DW Bowden

MAMMALIAN GENOME　Vol. 11　No. 10　p. 919-925　2000/10　Research paper (scientific journal)

Identification of CRAM, a novel unc-33 gene family protien that associates with CRMP3 and protein-tyrosine kinase(s) in the developing rat brain

Ryoko Inatome, Toshiaki Tsujimura, Tomohiro Hitomi, Norihiro Mitsui, Patrice Hermann, Shun'ichi Kuroda, Hirohei Yamamura, Shigeru Yanagi

Journal of Biological Chemistry　Vol. 275　No. 35　p. 27291-27302　2000/09/01　Research paper (scientific journal)

ENH, containing PDZ and LIM domains, heart/skeletal muscle-specific protein, associates with cytoskeletal proteins through the PDZ domain

N Nakagawa, M Hoshijima, M Oyasu, N Saito, K Tanizawa, S Kuroda

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 272　No. 2　p. 505-512　2000/06　Research paper (scientific journal)

Molecular cloning and heterologous expression of pea seedling copper amine oxidase

T Koyanagi, K Matsumura, S Kuroda, K Tanizawa

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY　Vol. 64　No. 4　p. 717-722　2000/04　Research paper (scientific journal)

Immunocytochemical localization of a neuron-specific thrombospondin-1-like protein, NELL2: light and electron microscopic studies in the rat brain

M Oyasu, S Kuroda, M Nakashita, M Fujimiya, U Kikkawa, N Saito

MOLECULAR BRAIN RESEARCH　Vol. 76　No. 1　p. 151-160　2000/03　Research paper (scientific journal)

Biochemical characterization and expression analysis of neural thrombospondin-1-like proteins NELL1 and NELL2

S Kuroda, M Oyasu, M Kawakami, N Kanayama, K Tanizawa, N Saito, T Abe, S Matsuhashi, K Ting

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 265　No. 1　p. 79-86　1999/11　Research paper (scientific journal)

Involvement of epidermal growth factor-like domain of NELL proteins in the novel protein-protein interaction with protein kinase C

S Kuroda, K Tanizawa

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 265　No. 3　p. 752-757　1999/11　Research paper (scientific journal)

Purification, characterization, and sequence determination of phospholipase D secreted by Streptoverticillium cinnamoneum

C Ogino, Y Negi, T Matsumiya, K Nakaoka, A Kondo, S Kuroda, S Tokuyama, U Kikkawa, T Yamane, H Fukuda

JOURNAL OF BIOCHEMISTRY　Vol. 125　No. 2　p. 263-269　1999/02　Research paper (scientific journal)

Mammalian homologue of the Caenorhabditis elegans UNC-76 protein involved in axonal outgrowth is a protein kinase C zeta-interacting protein

S Kuroda, N Nakagawa, C Tokunaga, K Tatematsu, K Tanizawa

JOURNAL OF CELL BIOLOGY　Vol. 144　No. 3　p. 403-411　1999/02　Research paper (scientific journal)

Human NELL-1 expressed in unilateral coronal synostosis

K Ting, H Vastardis, JB Mulliken, C Soo, A Tieu, H Do, E Kwong, CN Bertolami, H Kawamoto, S Kuroda, MT Longaker

JOURNAL OF BONE AND MINERAL RESEARCH　Vol. 14　No. 1　p. 80-89　1999/01　Research paper (scientific journal)

Requirement of G(M2) ganglioside activator for phospholipase D activation

S Nakamura, T Akisue, H Jinnai, T Hitomi, S Sarkar, N Miwa, T Okada, K Yoshida, S Kuroda, U Kikkawa, Y Nishizuka

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　Vol. 95　No. 21　p. 12249-12253　1998/10　Research paper (scientific journal)

Molecular cloning and characterization of RBCK2, a splicing variant of a RBCC family protein, RBCK1

C Tokunaga, K Tatematsu, S Kuroda, N Nakagawa, U Kikkawa

FEBS LETTERS　Vol. 435　No. 1　p. 11-15　1998/09　Research paper (scientific journal)

Phosphatidic acid-dependent phosphorylation of a 29-kDa protein by protein kinase C alpha in bovine brain cytosol

T Yokozeki, K Homma, S Kuroda, U Kikkawa, S Ohno, M Takahashi, K Imahori, Y Kanaho

JOURNAL OF NEUROCHEMISTRY　Vol. 71　No. 1　p. 410-417　1998/07　Research paper (scientific journal)

Transcriptional activity of RBCK1 protein (RBCC protein interacting with PKC 1): Requirement of RING-finger and B-Box motifs and regulation by protein kinases

K Tatematsu, C Tokunaga, N Nakagawa, K Tanizawa, S Kuroda, U Kikkawa

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 247　No. 2　p. 392-396　1998/06　Research paper (scientific journal)

Molecular cloning and characterization of a novel protein kinase C-interacting protein with structural motifs related to RBCC family proteins

C Tokunaga, S Kuroda, K Tatematsu, N Nakagawa, Y Ono, U Kikkawa

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 244　No. 2　p. 353-359　1998/03　Research paper (scientific journal)

Expression of a constitutively active phosphatidylinositol 3-kinase induces process formation in rat PC12 cells - Use of Cre/loxP recombination system

M Kobayashi, S Nagata, Y Kita, N Nakatsu, S Ihara, K Kaibuchi, S Kuroda, M Ui, H Iba, H Konishi, U Kikkawa, Saitoh, I, Y Fukui

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 272　No. 26　p. 16089-16092　1997/06　Research paper (scientific journal)

Activation of protein kinase B (Akt/RAC-protein kinase) by cellular stress and its association with heat shock protein Hsp27

H Konishi, H Matsuzaki, M Tanaka, Y Takemura, S Kuroda, Y Ono, U Kikkawa

FEBS LETTERS　Vol. 410　No. 2-3　p. 493-498　1997/06　Research paper (scientific journal)

Protein-protein interaction of zinc finger LIM domains with protein kinase C

S Kuroda, C Tokunaga, Y Kiyohara, O Higuchi, H Konishi, K Mizuno, GN Gill, U Kikkawa

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 271　No. 49　p. 31029-31032　1996/12　Research paper (scientific journal)

Isolation of the active form of RAC-protein kinase (PKB/Akt) from transfected COS-7 cells treated with heat shock stress and effects of phosphatidylinositol 3,4,5-trisphosphate and phosphatidylinositol 4,5-bisphosphate on its enzyme activity

H Matsuzaki, H Konishi, M Tanaka, Y Ono, T Takenawa, Y Watanabe, S Ozaki, S Kuroda, U Kikkawa

FEBS LETTERS　Vol. 396　No. 2-3　p. 305-308　1996/11　Research paper (scientific journal)

Development of pre-S2-containing hepatitis B vaccine produced by recombinant DNA technology

Y Fujisawa, S Kuroda, M Kobayashi, A Kakinuma

NIPPON NOGEIKAGAKU KAISHI-JOURNAL OF THE JAPAN SOCIETY FOR BIOSCIENCE BIOTECHNOLOGY AND AGROCHEMISTRY　Vol. 70　No. 9　p. 993-999　1996/09

Activation of RAC-protein kinase by heat shock and hyperosmolarity stress through a pathway independent of phosphatidylinositol 3-kinase

H Konishi, H Matsuzaki, M Tanaka, Y Ono, C Tokunaga, S Kuroda, U Kikkawa

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　Vol. 93　No. 15　p. 7639-7643　1996/07　Research paper (scientific journal)

MOLECULAR-CLONING AND CHARACTERIZATION OF A NEW MEMBER OF THE RAC PROTEIN-KINASE FAMILY - ASSOCIATION OF THE PLECKSTRIN HOMOLOGY DOMAIN OF 3 TYPES OF RAC PROTEIN-KINASE WITH PROTEIN-KINASE-C SUBSPECIES AND BETA-GAMMA-SUBUNITS OF G-PROTEINS

H KONISHI, S KURODA, M TANAKA, H MATSUZAKI, Y ONO, K KAMEYAMA, T HAGA, U KIKKAWA

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 216　No. 2　p. 526-534　1995/11　Research paper (scientific journal)

THE PLECKSTRIN HOMOLOGY DOMAIN OF RAC PROTEIN-KINASE ASSOCIATES WITH THE REGULATORY DOMAIN OF PROTEIN-KINASE-C-ZETA

H KONISHI, S KURODA, U KIKKAWA

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 205　No. 3　p. 1770-1775　1994/12　Research paper (scientific journal)

MOLECULAR-CLONING OF RAT RAC PROTEIN KINASE-ALPHA AND KINASE-BETA AND THEIR ASSOCIATION WITH PROTEIN-KINASE-C-ZETA

H KONISHI, T SHINOMURA, S KURODA, Y ONO, U KIKKAWA

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 205　No. 1　p. 817-825　1994/11　Research paper (scientific journal)

NOVEL SUBTYPE OF HUMAN ANGIOTENSIN-II TYPE-1 RECEPTOR - CDNA CLONING AND EXPRESSION

H KONISHI, S KURODA, Y INADA, Y FUJISAWA

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 199　No. 2　p. 467-474　1994/03　Research paper (scientific journal)

NOVEL SUBTYPE OF HUMAN ANGIOTENSIN-II TYPE-I RECEPTOR - ANALYSIS OF SIGNAL-TRANSDUCTION MECHANISM IN TRANSFECTED CHINESE-HAMSTER OVARY CELLS

S KURODA, H KONISHI, M OKISHIO, Y FUJISAWA

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 199　No. 2　p. 475-481　1994/03　Research paper (scientific journal)

FERMENTABLE AND NONFERMENTABLE CARBON-SOURCES SUSTAIN CONSTITUTIVE LEVELS OF EXPRESSION OF YEAST TRIOSEPHOSPHATE DEHYDROGENASE-3 GENE FROM DISTINCT PROMOTER ELEMENTS

S KURODA, S OTAKA, Y FUJISAWA

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 269　No. 8　p. 6153-6162　1994/02　Research paper (scientific journal)

Halystatin, a novel disintegrin from Agkistrodon halys, is a potent inhibitor of bone resorption and platelet aggregation

FUJISAWA Y.

J.Takeda Res. Lab.　Vol. 53　p. 39-56　1994

SACCHAROMYCES-CEREVISIAE CAN RELEASE HEPATITIS-B VIRUS SURFACE-ANTIGEN (HBSAG) PARTICLES INTO THE MEDIUM BY ITS SECRETORY APPARATUS

S KURODA, T MIYAZAKI, S OTAKA, Y FUJISAWA

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY　Vol. 40　No. 2-3　p. 333-340　1993/11　Research paper (scientific journal)

ADJUVANT-INDEPENDENT ENHANCED IMMUNE-RESPONSES TO RECOMBINANT HERPES-SIMPLEX VIRUS TYPE-1 GLYCOPROTEIN-D BY FUSION WITH BIOLOGICALLY-ACTIVE INTERLEUKIN-2

M HAZAMA, A MAYUMIAONO, N ASAKAWA, S KURODA, S HINUMA, Y FUJISAWA

VACCINE　Vol. 11　No. 6　p. 629-639　1993/04　Research paper (scientific journal)

Development of Novel Hepatitis B Vaccine.

Kuroda, S, Kobayashi, M

化学と生物　Vol. 31　p. 220-221　1993

TGP-943: Third Generation Hepatitis B Vaccine.

Fujisawa, Y, Kuroda, S

Drugs of the Future　Vol. 18　p. 612-615　1993

IDENTIFICATION OF POLYMERIZED-ALBUMIN RECEPTOR DOMAIN IN THE PRE-S2-REGION OF HEPATITIS-B VIRUS SURFACE ANTIGEN-M PROTEIN

Y ITOH, S KURODA, T MIYAZAKI, S OTAKA, Y FUJISAWA

JOURNAL OF BIOTECHNOLOGY　Vol. 23　No. 1　p. 71-82　1992/03　Research paper (scientific journal)

HEPATITIS-B VIRUS ENVELOPE L-PROTEIN PARTICLES - SYNTHESIS AND ASSEMBLY IN SACCHAROMYCES-CEREVISIAE, PURIFICATION AND CHARACTERIZATION

S KURODA, S OTAKA, T MIYAZAKI, M NAKAO, Y FUJISAWA

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 267　No. 3　p. 1953-1961　1992/01　Research paper (scientific journal)

INDUCTION OF PROTECTION LEVEL OF ANTI-PRE-S2 ANTIBODIES IN HUMANS IMMUNIZED WITH A NOVEL HEPATITIS-B VACCINE CONSISTING OF M (PRE-S2+S) PROTEIN PARTICLES (A 3RD GENERATION VACCINE)

S KURODA, Y FUJISAWA, S IINO, Y AKAHANE, H SUZUKI

VACCINE　Vol. 9　No. 3　p. 163-169　1991/03　Research paper (scientific journal)

Novel Hepatitis B Vaccine

Kuroda, S

発酵工学会誌　Vol. 69　1991

PROTECTIVE EFFICACY OF A NOVEL HEPATITIS-B VACCINE CONSISTING OF M(PRE-S2+S) PROTEIN PARTICLES (A 3RD GENERATION VACCINE)

Y FUJISAWA, S KURODA, PMCA VANEERD, H SCHELLEKENS, A KAKINUMA

VACCINE　Vol. 8　No. 3　p. 192-198　1990/06　Research paper (scientific journal)

QUANTITATIVE STRUCTURE ACTIVITY STUDIES OF PYRETHROIDS .20. RATE OF DEVELOPMENT OF KNOCKDOWN AND NEUROPHYSIOLOGICAL EFFECTS INDUCED BY META-PHENOXYBENZYL PYRETHRATE AND HOMOLOGS AND THEIR ALPHA-CYANO DERIVATIVES

K NISHIMURA, S KURODA, A SUGIYAMA, T FUJITA

PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY　Vol. 36　No. 3　p. 209-219　1990/03　Research paper (scientific journal)

ALANINE DEHYDROGENASES FROM 2 BACILLUS SPECIES WITH DISTINCT THERMOSTABILITIES - MOLECULAR-CLONING, DNA AND PROTEIN-SEQUENCE DETERMINATION, AND STRUCTURAL COMPARISON WITH OTHER NAD(P)+-DEPENDENT DEHYDROGENASES

S KURODA, K TANIZAWA, Y SAKAMOTO, H TANAKA, K SODA

BIOCHEMISTRY　Vol. 29　No. 4　p. 1009-1015　1990/01　Research paper (scientific journal)

EFFICIENT EXPRESSION OF GENETICALLY ENGINEERED HEPATITIS-B VIRUS SURFACE-ANTIGEN P-31 PROTEINS IN YEAST

S KURODA, Y ITOH, T MIYAZAKI, S OTAKAIMAI, Y FUJISAWA

GENE　Vol. 78　No. 2　p. 297-308　1989/05　Research paper (scientific journal)

A SUPERSENSITIVE DOT-HYBRIDIZATION METHOD - RAPID AND QUANTITATIVE DETECTION OF HOST-DERIVED DNA IN RECOMBINANT PRODUCTS AT THE ONE PICOGRAM LEVEL

S KURODA, Y ITOH, T MIYAZAKI, Y FUJISAWA

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 152　No. 1　p. 9-14　1988/04　Research paper (scientific journal)

QUANTITATIVE STRUCTURE - ACTIVITY STUDIES OF PYRETHROIDS .12. PHYSICOCHEMICAL SUBSTITUENT EFFECTS OF META-PHENOXYBENZYL ALPHA,ALPHA-DISUBSTITUTED ACETATES ON INSECTICIDAL ACTIVITY

HZ YANG, M NISHIMURA, K NISHIMURA, S KURODA, T FUJITA

PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY　Vol. 29　No. 3　p. 217-232　1987/11　Research paper (scientific journal)