慢性心不全患者における高齢がβ- blockerの投与量、有効性及び安全性に及ぼす影響に関する調査

武田 汐莉, 六車 萌恵, 前田 真一郎, 廣部 祥子, 藤尾 慈, 前田 真貴子

日本臨床薬理学会学術総会抄録集　Vol. 44　2023

LVAD装着患者におけるワルファリン維持投与量決定と遺伝子多型およびアミオダロン投与量の関連

齊藤 茉莉佳, 前田 真貴子, 牧口 実咲, 伊藤 仁人, 世良 英子, 佐村 高明, 大谷 朋仁, 吉岡 大輔, 宮川 繁, 坂田 泰史, 藤尾 慈

日本臨床薬理学会学術総会抄録集　Vol. 43回　p. 1-4　2022/12

Upregulation of OASIS/CREB3L1 in podocytes contributes to the disturbance of kidney homeostasis

Yoshiaki Miyake, Masanori Obana, Ayaha Yamamoto, Shunsuke Noda, Koki Tanaka, Hibiki Sakai, Narihito Tatsumoto, Chihiro Makino, Soshi Kanemoto, Go Shioi, Shota Tanaka, Makiko Maeda, Yoshiaki Okada, Kazunori Imaizumi, Katsuhiko Asanuma, Yasushi Fujio

Communications Biology　Vol. 5　No. 1　2022/12　Research paper (scientific journal)

Identification of biomarkers of chronic kidney disease among kidney-derived proteins

Kazuma Higashisaka, Sonoko Takeya, Haruhiko Kamada, Masanori Obana, Makiko Maeda, Mai Kabayama, Koichi Yamamoto, Nanan Ishida, Ryo Isaka, Hirofumi Tsujino, Kazuya Nagano, Noriyuki Tomiyama, Hiromi Rakugi, Yasushi Fujio, Kei Kamide, Yasuo Tsutsumi

Clinical Proteomics　Vol. 19　No. 1　2022/12　Research paper (scientific journal)

Warfarin Dosing Algorithms With the Information on Genotype and Amiodarone for Patients Without Extracorporeal Circulation Devices Could Be Beneficial for Those With Left Ventricular Assist Devices

Misaki Makiguchi, Makiko Maeda, Marika Saito, Yoshito Ito, Fusako Sera, Takaaki Samura, Takuji Kawamura, Ai Kawamura, Kaoru Kubota, Shinichiro Maeda, Noriyuki Kashiyama, Satoshi Kainuma, Tomohito Ohtani, Daisuke Yoshioka, Toshihiro Takeda, Yoshiki Sawa, Shigeru Miyagawa, Yasushi Sakata, Yasushi Fujio

CIRCULATION　Vol. 146　2022/11/08

The Dose Difference of Carvedilol for Heart Failure Management Between Asian-Americans and Japanese Could Show No Difference in the Improvement of Heart Function

Makiko Maeda, Douglas Humber, Eisuke Hida, Tomohito Ohtani, Guannan Wang, Tong Wu, Jun Hayashi, Jacinta N. Situ, Shiori Takeda, Hiroshi Okamoto, Toshihiro Takeda, Masatsugu Hori, Yasushi Sakata, Yasushi Fujio, Shirley Tsunoda

CIRCULATION　Vol. 146　2022/11/08

Myeloid cell-specific ablation of Runx2 gene exacerbates post-infarct cardiac remodeling.

Masashi Tomimatsu, Kotaro Matsumoto, Moe Ashizuka, Shohei Kumagai, Shota Tanaka, Takafumi Nakae, Kosei Yokota, Shunsuke Kominami, Ryota Kajiura, Daisuke Okuzaki, Daisuke Motooka, Aki Shiraishi, Takaya Abe, Hideo Matsuda, Yoshiaki Okada, Makiko Maeda, Shigeto Seno, Masanori Obana, Yasushi Fujio

Scientific reports　Vol. 12　No. 1　p. 16656-16656　2022/10/05　Research paper (scientific journal)

Glycoprotein 130 orchestrates signal transduction network to promote cardiomyocyte proliferation for normal growth

Masanori Obana, Makiko Maeda, Yasushi Fujio

American Journal of Physiology-Heart and Circulatory Physiology　Vol. 323　No. 1　p. H125-H127　2022/07/01　Research paper (scientific journal)

CXCL10 is a novel anti-angiogenic factor downstream of p53 in cardiomyocytes.

Tri Wahyuni, Shota Tanaka, Ryuta Igarashi, Yoshiaki Miyake, Ayaha Yamamoto, Shota Mori, Yusuke Kametani, Masashi Tomimatsu, Shota Suzuki, Kosei Yokota, Yoshiaki Okada, Makiko Maeda, Masanori Obana, Yasushi Fujio

Physiological reports　Vol. 10　No. 9　2022/05　Research paper (scientific journal)

Yes‐associated protein activation potentiates glycogen synthase kinase‐3 inhibitor‐induced proliferation of neonatal cardiomyocytes and iPS cell‐derived cardiomyocytes

Yusuke Kametani, Shota Tanaka, Yuriko Wada, Shota Suzuki, Ayaka Umeda, Kosuke Nishinaka, Yoshiaki Okada, Makiko Maeda, Shigeru Miyagawa, Yoshiki Sawa, Masanori Obana, Yasushi Fujio

Journal of Cellular Physiology　2022/03/21　Research paper (scientific journal)

アテゾリズマブの投与により早期に発現する副作用およびその発現に関連する因子の調査

秦 啓子, 中村 圭菜, 犬飼 萌乃, 前田 真一郎, 前田 真貴子, 藤尾 慈, 廣部 祥子

日本臨床薬理学会学術総会抄録集　Vol. 43　2022

Exhaustive exploration of novel factors related to cardiomyocyte proliferation using the cell cycle-sensitive protein FUCCI

Wada Yuriko, Kametani Yusuke, Suzuki Shota, Umeda Ayaka, Nishinaka Kosuke, Tanaka Shota, Maeda Makiko, Okada Yoshiaki, Obana Masanori, Fujio Yasushi

Proceedings for Annual Meeting of The Japanese Pharmacological Society　Vol. 95　2022

Endogenous YAP activity potentiates GSK3 inhibitors-induced proliferation of cardiomyocytes.

Kametani Yusuke, Suzuki Shota, Umeda Ayaka, Nishinaka Kosuke, Tanaka Shota, Maeda Makiko, Okada Yoshiaki, Obana Masanori, Fujio Yasushi

Proceedings for Annual Meeting of The Japanese Pharmacological Society　Vol. 95　2022

Increased OASIS in podocytes contributes to the disruption of kidney homeostasis

Miyake Yoshiaki, Obana Masanori, Yamamoto Ayaha, Tanaka Shota, Maeda Makiko, Okada Yoshiaki, Imaizumi Kazunori, Asanuma Katsuhiko, Fujio Yasushi

Proceedings for Annual Meeting of The Japanese Pharmacological Society　Vol. 95　2022

IL-6 family cytokines, STAT3 activators, exhibit differential effects in a ligand-specific manner in podocytes

Sayuri Mitsuoka, Obana Masanori, Miyake Yoshiaki, Yamamoto Ayaha, Tanaka Shota, Maeda Makiko, Okada Yoshiaki, Fujio Yasushi

Proceedings for Annual Meeting of The Japanese Pharmacological Society　Vol. 95　2022

TGFβ3 exacerbates myocardial remodeling after myocardial infarction.

Tomimatsu Masashi, Yokota Kosei, Kominami Shunsuke, Tanaka Shota, Maeda Makiko, Okada Yoshiaki, Obana Masanori, Fujio Yasushi

Proceedings for Annual Meeting of The Japanese Pharmacological Society　Vol. 95　2022

Leupaxin is upregulated in fibrotic kidneys and contributes to the proliferation of kidney fibroblasts

Noda Shunsuke, Obana Masanori, Miyake Yoshiaki, Yamamoto Ayaha, Tanaka Shota, Maeda Makiko, Okada Yoshiaki, Fujio Yasushi

Proceedings for Annual Meeting of The Japanese Pharmacological Society　Vol. 95　2022

PKNOX2 regulates myofibroblast functions and tubular cell survival during kidney fibrosis.

Yoshiaki Miyake, Masanori Obana, Takafumi Nakae, Ayaha Yamamoto, Shota Tanaka, Makiko Maeda, Yoshiaki Okada, Yasushi Fujio

Biochemical and biophysical research communications　Vol. 571　p. 88-95　2021/09/24　Research paper (scientific journal)

Maresin-1 induces cardiomyocyte hypertrophy through IGF-1 paracrine pathway.

Tri Wahyuni, Arisa Kobayashi, Shota Tanaka, Yoshiaki Miyake, Ayaha Yamamoto, Anton Bahtiar, Shota Mori, Yusuke Kametani, Masashi Tomimatsu, Kotaro Matsumoto, Makiko Maeda, Masanori Obana, Yasushi Fujio

American journal of physiology. Cell physiology　Vol. 321　No. 1　2021/07/01　Research paper (scientific journal)

Gene transfer by pyro-drive jet injector is a novel therapeutic approach for muscle diseases.

Takafumi Nakae, Masanori Obana, Takahiro Maeda, Akari Ikeda, Hiroshi Miyazaki, Shota Tanaka, Makiko Maeda, Kunihiko Yamashita, Kazuhiro Terai, Satoshi Obika, Yasushi Fujio

Gene　Vol. 788　p. 145664-145664　2021/07/01　Research paper (scientific journal)

ポドサイトの転写因子OASISは腎病態進展に寄与する

三宅 芳明, 尾花 理徳, 山本 彩葉, 田中 翔大, 前田 真貴子, 今泉 和則, 淺沼 克彦, 藤尾 慈

日本腎臓学会誌　Vol. 63　No. 4　p. 499-499　2021/06

Transcription factor old astrocyte specifically induced substance is a novel regulator of kidney fibrosis.

Ayaha Yamamoto, Hitomi Morioki, Takafumi Nakae, Yoshiaki Miyake, Takeo Harada, Shunsuke Noda, Sayuri Mitsuoka, Kotaro Matsumoto, Masashi Tomimatsu, Soshi Kanemoto, Shota Tanaka, Makiko Maeda, Simon J Conway, Kazunori Imaizumi, Yasushi Fujio, Masanori Obana

FASEB journal : official publication of the Federation of American Societies for Experimental Biology　Vol. 35　No. 2　2021/02　Research paper (scientific journal)

Activation of YAP is essential for the myocardial recovery from myocarditis

Fukuyama Shoki, Kametani Yusuke, Wada Yuriko, Suzuki Shota, Umeda Ayaka, Maeda Makiko, Tanaka Shota, Obana Masanori, Fujio Yasushi

Proceedings for Annual Meeting of The Japanese Pharmacological Society　Vol. 94　2021

Acute kidney injury-induced ZBTB38 contributes to tubular cell loss.

Harada Takeo, Obana Masanori, Miyake Yosiaki, Yamamoto Ayaha, Kamuro Hiroyasu, Tanaka Syota, Maeda Makiko, Fujio Yasushi

Proceedings for Annual Meeting of The Japanese Pharmacological Society　Vol. 94　2021

Establishment of a novel experimental autoimmune vasculitis model

Seo Takafumi, Tanaka Shota, Maeda Makiko, Obana Masanori, Fujio Yasushi

Proceedings for Annual Meeting of The Japanese Pharmacological Society　Vol. 94　2021

Cardioprotective roles of novel cell death inhibitor, defender against cell death 1 (Dad1)

Mori Shota, Tanaka Shota, Maeda Makiko, Obana Masanori, Fujio Yasushi

Proceedings for Annual Meeting of The Japanese Pharmacological Society　Vol. 94　2021

CXCL10 is an anti-angiogenic factor downstream of p53 in cardiomyocytes.

Igarashi Ryuta, Tomimatsu Masashi, Maeda Makiko, Tanaka Syota, Obana Masanori, Fujio Yasushi

Proceedings for Annual Meeting of The Japanese Pharmacological Society　Vol. 94　2021

Vascular Endothelial Growth Factor Receptor Inhibitors Impair Left Ventricular Diastolic Functions.

Haruka Yokoyama, Wataru Shioyama, Takuya Shintani, Shinichiro Maeda, Sachiko Hirobe, Makiko Maeda, Yasushi Sakata, Yasushi Fujio

International heart journal　Vol. 62　No. 6　p. 1297-1304　2021　Research paper (scientific journal)

Maresin 1 Induces Cardiomyocyte Hypertrophy Through RORα/IGF-1/PI3K/Akt Pathway

Tri Wahyuni, Arisa Kobayashi, Shota Tanaka, Yoshiaki Miyake, Ayaha Yamamoto, Anton Bahtiar, Matsumoto Kotaro, Makiko Maeda, Masanori Obana, Yasushi Fujio

CIRCULATION　Vol. 142　2020/11/17

β2-adrenergic Signaling Promotes IL-6 Production From Cardiac Fibroblasts Through CREB/Arid5a Pathway and Induces Cardiac Hypertrophy via Paracrine System

Shota Tanaka, Makiko Maeda, Masanori Obana, Yasushi Fujio

CIRCULATION　Vol. 142　2020/11/17

β2-adrenergic stimulation induces interleukin-6 by increasing Arid5a, a stabilizer of mRNA, through cAMP/PKA/CREB pathway in cardiac fibroblasts.

Shota Tanaka, Atsuki Imaeda, Kotaro Matsumoto, Makiko Maeda, Masanori Obana, Yasushi Fujio

Pharmacology research & perspectives　Vol. 8　No. 2　2020/04　Research paper (scientific journal)

Influence of proton pump inhibitors on mycophenolic acid in heart transplant recipients

前田真一郎, 前田真一郎, 栗原由美子, 廣部祥子, 廣部祥子, 廣部祥子, 前田真貴子, 前田真貴子, 藤尾慈, 藤尾慈

日本薬学会年会要旨集(Web)　Vol. 140年会　p. 26M-am11　2020/03

Population pharmacokinetics of tacrolimus in adult heart transplant recipients

近藤研太朗, 吉田茉莉, 廣部祥子, 廣部祥子, 廣部祥子, 前田真貴子, 前田真貴子, 藤尾慈, 藤尾慈, 前田真一郎, 前田真一郎

日本薬学会年会要旨集(Web)　Vol. 140年会　p. 27Z-am03S　2020/03

Research for predictive factors of moderate or severe infusion reaction by rituximab

深田耕司, 宮本真由, 犬飼萌乃, 前田真一郎, 前田真一郎, 前田真一郎, 前田真貴子, 前田真貴子, 前田真貴子, 藤尾慈, 藤尾慈, 藤尾慈, 廣部祥子, 廣部祥子, 廣部祥子, 廣部祥子

日本薬学会年会要旨集(Web)　Vol. 140年会　p. 27Q-am163S　2020/03

Inhibition of transcription factor OASIS attenuated kidney fibrosis

Yamamoto Ayaha, Obana Masanori, Nakae Takafumi, Miyake Yoshiaki, Mitsuoka Sayuri, Maeda Makiko, Imaizumi Kazunori, Matsumoto Kotaro, Fujio Yasushi

Proceedings for Annual Meeting of The Japanese Pharmacological Society　Vol. 93　2020

Development of a screening system for the compounds that induce the cell cycle activity in mammalian cardiomyocytes

Matsui Risa, Fukuyama Shoki, Kametani Yusuke, Wada Yuriko, Matsumoto Kotaro, Maeda Makiko, Obana Masanori, Fujio Yasushi

Proceedings for Annual Meeting of The Japanese Pharmacological Society　Vol. 93　2020

Dad1 inhibits cardiomyocyte death by promoting cell adhesion

Shota Mori, Kimura Rumi, Fuchigami Shota, Matsumoto Kotaro, Maeda Makiko, Obana Masanori, Fujio Yasushi

Proceedings for Annual Meeting of The Japanese Pharmacological Society　Vol. 93　2020

β2 adrenergic signaling of cardiac fibroblasts induces cardiac hypertrophy through paracrine system

Imaeda Atsuki, Tanaka Shota, Matsumoto Kotaro, Maeda Makiko, Obana Masanori, Fujio Yasushi

Proceedings for Annual Meeting of The Japanese Pharmacological Society　Vol. 93　2020

β2-adrenergic stimulation induces Arid5a through cAMP/PKA/CREB axis to promote IL-6 upregulation

Tanaka Shota, Imaeda Atsuki, Matsumoto Kotaro, Maeda Makiko, Obana Masanori, Fujio Yasushi

Proceedings for Annual Meeting of The Japanese Pharmacological Society　Vol. 93　2020

Maresin 1, an anti-inflammatory lipid mediator, induces physiological hypertrophy in neonatal rat cardiomyocytes

Kobayashi Arisa, Tri Wahyuni, Igarashi Ryuta, Tomimatsu Masashi, Matsumoto Kotaro, Maeda Makiko, Obana Masanori, Fujio Yasushi

Proceedings for Annual Meeting of The Japanese Pharmacological Society　Vol. 93　2020

Verification of pharmacogenomics-based algorithms to predict warfarin maintenance dose using registered data of Japanese patients.

Maki Sasano, Masako Ohno, Yuya Fukuda, Shinpei Nonen, Sachiko Hirobe, Shichiro Maeda: Yoshihiro Miwa, Junya Yokoyama, Hiroyuki Nakayama, Shigeru Miyagawa, Yoshiki Sawa, Yasushi Fujio, Makiko Maeda

European journal of clinical pharmacology　Vol. 75　No. 7　p. 901-911　2019/07　Research paper (scientific journal)

Blockade of NKG2D/NKG2D ligand interaction attenuated cardiac remodelling after myocardial infarction.

Kotaro Matsumoto, Masanori Obana, Arisa Kobayashi, Miho Kihara, Go Shioi, Shigeru Miyagawa, Makiko Maeda, Yasushi Sakata, Hiroyuki Nakayama, Yoshiki Sawa, Yasushi Fujio

Cardiovascular research　Vol. 115　No. 4　p. 765-775　2019/03/15　Research paper (scientific journal)

Myofibroblast β2 adrenergic signaling amplifies cardiac hypertrophy in mice.

Atsuki Imaeda, Shota Tanaka, Kota Tonegawa, Shota Fuchigami, Masanori Obana, Makiko Maeda, Miho Kihara, Hiroshi Kiyonari, Simon J Conway, Yasushi Fujio, Hiroyuki Nakayama

Biochemical and biophysical research communications　Vol. 510　No. 1　p. 149-155　2019/02/26　Research paper (scientific journal)

Inhibition of OASIS in podocytes suppressed diabetes-induced kidney dysfunction

Miyake Yoshiaki, Obana Masanori, Yamamoto Ayaha, Noda Shunsuke, Kanemoto Soshi, Maeda Makiko, Asanuma Katsuhiko, Imaizumi Kazunori, Nakayama Hiroyuki, Fujio Yasushi

Proceedings for Annual Meeting of The Japanese Pharmacological Society　Vol. 92　2019

Characterization of mononuclear cardiomyocytes in adult murine hearts

Nakayasu Yusuke, Matsui Risa, Fukuyama Shoki, Kametani Yusuke, Wada Yuriko, Obana Masanori, Maeda Makiko, Nakayama Hiroyuki, Fujio Yasushi

Proceedings for Annual Meeting of The Japanese Pharmacological Society　Vol. 92　2019

Suppression of Defender against cell death 1 leads to cardiomyocyte death

Fuchigami Shota, Kimura Rumi, Matumoto Kotaro, Morihara Hirofumi, Mori Shota, Obana Masonori, Maeda Makiko, Fujio Yasushi, Nakayama Hiroyuki

Proceedings for Annual Meeting of The Japanese Pharmacological Society　Vol. 92　2019

Comprehensive search for cardiomyocyte death-related genes using forward genetic screening

Nakayama Nami, Seo Takafumi, Obana Masanori, Maeda Makiko, Fujio Yasushi, Nakayama Hiroyuki

Proceedings for Annual Meeting of The Japanese Pharmacological Society　Vol. 92　2019

The overexpression of CGRRF1 induces hypertrophy in cultured cardiomyocytes

Kinoshita Maki, Obana Masanori, Maeda Makiko, Nakayama Hiroyuki, Fujio Yasushi

Proceedings for Annual Meeting of The Japanese Pharmacological Society　Vol. 92　2019

ドラッグリポジショニングによる心筋保護サイトカイン治療開発の試み

前田 真貴子, 藤尾 慈

ファルマシア　Vol. 55　No. 3　p. 218-222　2019

Runx2-expressing myeloid cells ameliorate post-infarct cardiac remodeling as a novel cardioprotective subset

Matsumoto Kotaro, Ashizuka Moe, Kumagai Shohei, Okuzaki Daisuke, Obana Masanori, Maeda Makiko, Nakayama Hiroyuki, Fujio Yasushi

Proceedings for Annual Meeting of The Japanese Pharmacological Society　Vol. 92　p. 2-YIA-10　2019

Eukaryotic translation initiation factor 3 subunit C is associated with acquired resistance to erlotinib in non-small cell lung cancer.

Takuya Shintani, Kazuma Higashisaka, Makiko Maeda, Masaya Hamada, Ryosuke Tsuji, Koudai Kurihara, Yuri Kashiwagi, Atsuhiro Sato, Masanori Obana, Ayaha Yamamoto, Keisuke Kawasaki, Ying Lin, Takashi Kijima, Yuhei Kinehara, Yoshihiro Miwa, Shinichiro Maeda, Eiichi Morii, Atsushi Kumanogoh, Yasuo Tsutsumi, Izumi Nagatomo, Yasushi Fujio

Oncotarget　Vol. 9　No. 101　p. 37520-37533　2018/12/25　Research paper (scientific journal)

Pharmacogenomics-Based Prediction of Warfarin Maintenance Dose Overrides Racial Differences

Maki Sasano, Makiko Maeda, Masako Ohno, Yuya Fukuda, Shinichiro Maeda, Junya Yokoyama, Shigeru Miyagawa, Yoshiki Sawa, Yasushi Fujio

CIRCULATION　Vol. 138　2018/11/06

慢性腎臓病に対する診断バイオマーカーの確立に向けた腎分泌蛋白質の有用性評価

石田 菜南, 東阪 和馬, 竹谷 苑子, 井阪 亮, 尾花 理徳, 鎌田 春彦, 前田 真貴子, 長野 一也, 藤尾 慈, 神出 計, 堤 康央

日本薬学会年会要旨集　Vol. 138年会　No. 4　p. 188-188　2018/03

Safety and Feasibility Report of Investigational Therapy With Interleukin-11 Against Acute Myocardial Infarction

Maeda Makiko, Nakagawa Masaki, Owada Yasuko, Izumi Yasukatsu, Nonin Shinichi, Sugioka Kenichi, Nakatani Daisaku, Iwata Shinichi, Mizutani Kazuki, Nishimura Satoshi, Ito Asahiro, Fujita Suwako, Daimon Takashi, Sawa Yoshiki, Asakura Masanori, Fujio Yasushi, Yoshiyama Minoru

CIRCULATION　Vol. 136　2017/11/14

Myofibroblast-Specific Deletion of Runx2 Improves Systolic Function and Survival in Late Phase of Cardiac Remodeling After Myocardial Infarction

Tanaka Shota, Enomoto Daichi, Yanase Emiko, Kumagai Shohei, Obana Masanori, Maeda Makiko, Fujio Yasushi, Nakayama Hiroyuki

CIRCULATION　Vol. 136　2017/11/14

Adult murine cardiomyocytes exhibit regenerative activity with cell cycle reentry through STAT3 in the healing process of myocarditis.

Akimitsu Miyawaki, Masanori Obana, Yusuke Mitsuhara, Aya Orimoto, Yusuke Nakayasu, Tomomi Yamashita, So-Ichiro Fukada, Makiko Maeda, Hiroyuki Nakayama, Yasushi Fujio

Scientific reports　Vol. 7　No. 1　p. 1407-1407　2017/05/03　Research paper (scientific journal)

Phospholamban Inhibition by a Single Dose of Locked Nucleic Acid Antisense Oligonucleotide Improves Cardiac Contractility in Pressure Overload-Induced Systolic Dysfunction in Mice.

Hirofumi Morihara, Tsuyoshi Yamamoto, Harunori Oiwa, Kota Tonegawa, Daisuke Tsuchiyama, Ikki Kawakatsu, Masanori Obana, Makiko Maeda, Tomomi Mohri, Satoshi Obika, Yasushi Fujio, Hiroyuki Nakayama

Journal of cardiovascular pharmacology and therapeutics　Vol. 22　No. 3　p. 273-282　2017/05　Research paper (scientific journal)

Interleukin-11 therapy for cardioprotection against acute myocardial infarction

Fujio Yasushi, Maeda Makiko, Daimon Takashi, Nakatani Daisaku, Sugioka Kinichi, Iwata Shinichi, Sawa Yoshiki, Asakura Masanori, Izumi Yasukatsu, Yoshiyama Minoru

JOURNAL OF PHARMACOLOGICAL SCIENCES　Vol. 133　No. 3　2017/03

ROR gamma t heterozygous deficiency aggravates cardiac remodeling after myocardial infarction

Enomoto Daichi, Obana Masanori, Matsumoto Kotaro, Maeda Makiko, Nakayama Hiroyuki, Fujio Yasushi

JOURNAL OF PHARMACOLOGICAL SCIENCES　Vol. 133　No. 3　2017/03

Fibroblast-specific PKA activation induces cardiac hypertrophy

Takahashi Misato, Tonegawa Kota, Fuchigami Shota, Tanaka Shota, Obana Masanori, Maeda Makiko, Fujio Yasushi, Nakayama Hiroyuki

JOURNAL OF PHARMACOLOGICAL SCIENCES　Vol. 133　No. 3　2017/03

Elucidation of underlying mechanism of dynasore against ROS-induced CM death

Kawakatsu Ikki, Morihara Hirofumi, Kimura Rumi, Kubo Mikiko, Tsuchiyama Daisuke, Obana Masanori, Maeda Makiko, Fujio Yasushi, Nakayama Hiroyuki

JOURNAL OF PHARMACOLOGICAL SCIENCES　Vol. 133　No. 3　2017/03

Myeloid cell-specific Runx2 ablation attenuates adverse cardiac remodeling after myocardial infarction

Ashizuka Moe, Kumagai Syohei, Yanase Emiko, Matsumoto Kotaro, Ghana Masanori, Maeda Makiko, Nakayama Hiroyuki, Fujin Yasushi

JOURNAL OF PHARMACOLOGICAL SCIENCES　Vol. 133　No. 3　2017/03

The deletion of Runx2 in fibroblasts has a protective role after MI

Yanase Emiko, Tanaka Shouta, Kumagai Shouhei, Enomoto Daichi, Nakayama Nami, Obana Masanori, Maeda Makiko, Fujio Yasushi, Nakayama Hiroyuki

JOURNAL OF PHARMACOLOGICAL SCIENCES　Vol. 133　No. 3　2017/03

Moesin is activated in cardiomyocytes in experimental autoimmune myocarditis and mediates tissue restoration with protrusion formation

Mitsuhara Yusuke, Miyawaki Akimitsu, Orimoto Aya, Nakayasu Yusuke, Tsunoda Shin-ichi, Obana Masanori, Maeda Makiko, Nakayama Hiroyuki, Yoshioka Yasuo, Tsutsumi Yasuo, Fujio Yasushi

JOURNAL OF PHARMACOLOGICAL SCIENCES　Vol. 133　No. 3　2017/03

eIF4B is a cytoprotective molecule downstream of Pim-1 kinase in cardiomyocytes

Yokoyama Yukari, Matsumoto Kotaro, Kinoshita Maki, Obana Masanori, Maeda Makiko, Nakayama Hiroyuki, Fujio Yasushi

JOURNAL OF PHARMACOLOGICAL SCIENCES　Vol. 133　No. 3　2017/03

Caveolae-specific activation loop between CaMKII and L-type Ca2+ channel aggravates cardiac hypertrophy in α1-adrenergic stimulation.

Kota Tonegawa, Wataru Otsuka, Shohei Kumagai, Sachi Matsunami, Nao Hayamizu, Shota Tanaka, Kazumasa Moriwaki, Masanori Obana, Makiko Maeda, Michio Asahi, Hiroshi Kiyonari, Yasushi Fujio, Hiroyuki Nakayama

American journal of physiology. Heart and circulatory physiology　Vol. 312　No. 3　p. H501-H514-H514　2017/03/01　Research paper (scientific journal)

RORγt-expressing cells attenuate cardiac remodeling after myocardial infarction.

Daichi Enomoto, Kotaro Matsumoto, Tomomi Yamashita, Arisa Kobayashi, Makiko Maeda, Hiroyuki Nakayama, Masanori Obana, Yasushi Fujio

PloS one　Vol. 12　No. 8　2017　Research paper (scientific journal)

2-aminoethoxydiphenyl borate provides an anti-oxidative effect and mediates cardioprotection during ischemia reperfusion in mice.

Hirofumi Morihara, Masanori Obana, Shota Tanaka, Ikki Kawakatsu, Daisuke Tsuchiyama, Shota Mori, Hiroshi Suizu, Akiko Ishida, Rumi Kimura, Izuru Tsuchimochi, Makiko Maeda, Takehiko Yoshimitsu, Yasushi Fujio, Hiroyuki Nakayama

PloS one　Vol. 12　No. 12　2017　Research paper (scientific journal)

Myeloid Cell-Specific Runx2 Deficiency Exacerbates Adverse Cardiac Remodeling After Myocardial Infarction

Moe Ashizuka, Shouhei Kumagai, Emiko Yanase, Masanori Obana, Makiko Maeda, Yasushi Sakata, Hiroyuki Nakayama, Yasushi Fujio

CIRCULATION　Vol. 134　2016/11

Heterozygous Ablation of ROR gamma t Gene Deteriorates Adverse Cardiac Remodeling After Myocardial Infarction

Daichi Enomoto, Masanori Obana, Kotaro Matsumoto, Yasushi Sakata, Makiko Maeda, Hiroyuki Nakayama, Yasushi Fujio

CIRCULATION　Vol. 134　2016/11

Adult Mammalian Hearts Restore Intrinsic Regenerative Capacity Through Signal Transducer and Activation of Transcription 3 in the Resolution Phase of Myocarditis

Akimitsu Miyawaki, Masanori Obana, Yusuke Mitsuhara, Aya Orimoto, Yusuke Nakayasu, Tomomi Yamashita, So-ichiro Fukada, Makiko Maeda, Yasushi Sakata, Hiroyuki Nakayama, Yasushi Fujio

CIRCULATION　Vol. 134　2016/11

Fibroblast-specific Beta-adrenergic Receptor Signaling Regulates Cardiac Hypertrophy in Mice

Kota Tonegawa, Shota Tanaka, Misato Takahashi, Shota Fuchigami, Masanori Obana, Makiko Maeda, Yasushi Sakata, Yasushi Fujio, Hiroyuki Nakayama

CIRCULATION　Vol. 134　2016/11

Four cases of investigational therapy with interleukin-11 against acute myocardial infarction.

Masashi Nakagawa, Yasuko Owada, Yasukatsu Izumi, Shinichi Nonin, Kenichi Sugioka, Daisaku Nakatani, Shinichi Iwata, Kazuki Mizutani, Satoshi Nishimura, Asahiro Ito, Suwako Fujita, Takashi Daimon, Yoshiki Sawa, Masanori Asakura, Makiko Maeda, Yasushi Fujio, Minoru Yoshiyama

Heart and vessels　Vol. 31　No. 9　p. 1574-8　2016/09　Research paper (scientific journal)

Moesin is activated in cardiomyocytes in experimental autoimmune myocarditis and mediates cytoskeletal reorganization with protrusion formation.

Akimitsu Miyawaki, Yusuke Mitsuhara, Aya Orimoto, Yusuke Nakayasu, Shin-Ichi Tsunoda, Masanori Obana, Makiko Maeda, Hiroyuki Nakayama, Yasuo Yoshioka, Yasuo Tsutsumi, Yasushi Fujio

American journal of physiology. Heart and circulatory physiology　Vol. 311　No. 2　p. H476-86-H486　2016/08/01　Research paper (scientific journal)

Adult cardiomyocytes restore intrinsic regenerative capacity through STAT3 activation in the inflamed murine heart

Miyawaki Akimitsu, Takaya Tamaki, Mitsuhara Yusuke, Yamashita Tomomi, Obana Masanori, Maeda Makiko, Nakayama Hiroyuki, Fujio Yasushi

JOURNAL OF PHARMACOLOGICAL SCIENCES　Vol. 130　No. 3　2016/03

Elucidation of underlying mechanism of 2-APB against ROS-induced CM death

Ishida Akiko, Morihara Hirofumi, Kawakatsu Ikki, Tsuchiyama Daisuke, Kubo Mikiko, Obana Masanori, Maeda Makiko, Fujio Yasushi, Nakayama Hiroyuki

JOURNAL OF PHARMACOLOGICAL SCIENCES　Vol. 130　No. 3　2016/03

Adrenergic Receptors beta 2 and beta 3 Transduce Differential Signals in Cardiac Fibroblasts

Kota Tonegawa, Hiroyuki Nakayama, Hiromi Igarashi, Sachi Matsunami, Nao Hayamizu, Masanori Obana, Makiko Maeda, Yasushi Fujio

CIRCULATION　Vol. 132　2015/11

Blockade of NKG2D/NKG2D Ligands Interaction Attenuated Cardiac Remodeling After Myocardial Infarction

Kotaro Matsumoto, Masanori Obana, Rina Hashizume, Yukari Yokoyama, Shigeru Miyagawa, Tomomi Mohri, Makiko Maeda, Hiroyuki Nakayama, Yoshiki Sawa, Yasushi Fujio

CIRCULATION　Vol. 132　2015/11

Interleukin-27 induces the endothelial differentiation in Sca-1+ cardiac resident stem cells.

Tomohiro Tanaka, Masanori Obana, Tomomi Mohri, Masaki Ebara, Yuta Otani, Makiko Maeda, Yasushi Fujio

Cytokine　Vol. 75　No. 2　p. 365-72　2015/10　Research paper (scientific journal)

Cardiac-specific ablation of the STAT3 gene in the subacute phase of myocardial infarction exacerbated cardiac remodeling.

Daichi Enomoto, Masanori Obana, Akimitsu Miyawaki, Makiko Maeda, Hiroyuki Nakayama, Yasushi Fujio

American journal of physiology. Heart and circulatory physiology　Vol. 309　No. 3　p. H471-80-H480　2015/08/01　Research paper (scientific journal)

Elucidation of molecular mechanism of cardiomyocyte necrosis induced by reactive oxygen species

Tsuchiyama Daisuke, Nakayama Hiroyuki, Morihara Hirofumi, Ishida Akiko, Obana Masanori, Maeda Makiko, Fujio Yasushi

JOURNAL OF PHARMACOLOGICAL SCIENCES　Vol. 128　No. 3　2015/07

Interleukin 27 induces endothelial differentiation in murine cardiac stem cells

Tanaka Tomohiro, Obana Masanori, Maeda Makiko, Nakayama Hiroyuki, Fujio Yasushi

JOURNAL OF PHARMACOLOGICAL SCIENCES　Vol. 128　No. 3　2015/07

IL-27 negatively regulates murine experimental autoimmune myocarditis (EAM)

Furutani Chika, Miyawaki Akimitsu, Otani Yuta, Obana Masanori, Maeda Makiko, Nakayama Hiroyuki, Fujio Yasushi

JOURNAL OF PHARMACOLOGICAL SCIENCES　Vol. 128　No. 3　2015/07

The properties of cardiac Sca-1+resident stem cells are altered in response to myocardial inflammation

Matsuhara Yumi, Miyawaki Akimitsu, Ebara Masaki, Obana Masanori, Maeda Makiko, Nakayama Hiroyuki, Fujio Yasushi

JOURNAL OF PHARMACOLOGICAL SCIENCES　Vol. 128　No. 3　2015/07

Vascular Functional and Morphological Alterations in Smokers during Varenicline Therapy.

Masanori Kobayashi, Yasuhiko Takemoto, Naoki Norioka, Tomokazu Iguchi, Kenei Shimada, Makiko Maeda, Mina Morimura, Yasushi Fujio, Junichi Azuma, Minoru Yoshiyama, Kazuhiro Hirohashi, Taichi Shuto

Osaka city medical journal　Vol. 61　No. 1　p. 19-30　2015/06　Research paper (scientific journal)

A novel cytokine therapy for cardiovascular disease

Yasuko Owada, Makiko Maeda, Yasushi Fujio

Japanese Journal of Clinical Chemistry　Vol. 43　No. 3　p. 191-196　2014　Research paper (scientific journal)

The inhibition of N-glycosylation of glycoprotein 130 molecule abolishes STAT3 activation by IL-6 family cytokines in cultured cardiac myocytes.

Reo Matsuo, Hirofumi Morihara, Tomomi Mohri, Shiho Murasawa, Kana Takewaki, Hiroyuki Nakayama, Makiko Maeda, Yasushi Fujio

PloS one　Vol. 9　No. 10　2014　Research paper (scientific journal)

A report From the Japanese pharmacogenomics clinical trial; CYP2A6 Gene Polymorphisms Influence Nicotine Dependence and Monoamine Oxidase Gene Polymorphism Does Smoking Cessation Behavior

CIRCULATION　Vol. 128　No. 22　2013/11/26

Therapeutic administration of IL-11 exhibits the postconditioning effects against ischemia-reperfusion injury via STAT3 in the heart.

Masanori Obana, Kaori Miyamoto, Shiho Murasawa, Tomohiko Iwakura, Akiko Hayama, Tomomi Yamashita, Momoko Shiragaki, Shohei Kumagai, Akimitsu Miyawaki, Kana Takewaki, Goro Matsumiya, Makiko Maeda, Minoru Yoshiyama, Hiroyuki Nakayama, Yasushi Fujio

American journal of physiology. Heart and circulatory physiology　Vol. 303　No. 5　p. H569-77-H577　2012/09/01　Research paper (scientific journal)

Interleukin-11 Exhibits the Post-conditioning Effects against Ischemia Reperfusion injury via Cardiac Signal Transducer and Activator of Transcription 3

Kaori Miyamoto, Masanori Obana, Makiko Maeda, Hiroyuki Nakayama, Yasushi Fujio

JOURNAL OF PHARMACOLOGICAL SCIENCES　Vol. 118　p. 86P-86P　2012

Interleukin-11 Attenuates Infarct Size And Improves Ventricular Function In a Canine Heart Model Of Ischemia/Reperfusion Injury

Makiko Maeda, Koji Takeda, Goro Matsumiya, Junichi Azuma, Yasushi Fujio

JOURNAL OF PHARMACOLOGICAL SCIENCES　Vol. 118　p. 244P-244P　2012

Glycoprotein 130 Cytokine Signal as a Therapeutic Target Against Cardiovascular Diseases

Yasushi Fujio, Makiko Maeda, Tomomi Mohri, Masanori Obana, Tomohiko Iwakura, Akiko Hayama, Tomomi Yamashita, Hiroyuki Nakayama, Junichi Azuma

JOURNAL OF PHARMACOLOGICAL SCIENCES　Vol. 117　No. 4　p. 213-222　2011/12　Research paper (scientific journal)

Association between osteopontin promoter variants and diastolic dysfunction in hypertensive heart in the Japanese population

Hiroyuki Nakayama, Hiromi Nagai, Kyotaka Matsumoto, Ryosuke Oguro, Ken Sugimoto, Kei Kamide, Mitsuru Ohishi, Tomohiro Katsuya, Hiroshi Okamoto, Makiko Maeda, Kazuo Komamura, Junichi Azuma, Hiromi Rakugi, Yasushi Fujio

HYPERTENSION RESEARCH　Vol. 34　No. 10　p. 1141-1146　2011/10　Research paper (scientific journal)

Genetic analysis for nicotine dependence

Maeda M, Fujio Y, Azuma J

Nihon rinsho. Japanese journal of clinical medicine　Vol. 69　No. 10　p. 1887-1890　2011/10　Research paper (scientific journal)

IL-6-mediated Th17 differentiation through ROR gamma t is essential for the initiation of experimental autoimmune myocarditis

Tomomi Yamashita, Tomohiko Iwakura, Kazuki Matsui, Haruyo Kawaguchi, Masanori Obana, Akiko Hayama, Makiko Maeda, Yasukatsu Izumi, Issei Komuro, Yoshiyuki Ohsugi, Minoru Fujimoto, Tetsuji Naka, Tadamitsu Kishimoto, Hiroyuki Nakayama, Yasushi Fujio

CARDIOVASCULAR RESEARCH　Vol. 91　No. 4　p. 640-648　2011/09　Research paper (scientific journal)

STAT3/Pim-1 signaling pathway plays a crucial role in endothelial differentiation of cardiac resident Sca-1+cells both in vitro and in vivo

Tomohiko Iwakura, Tomomi Mohri, Tatsuto Hamatani, Masanori Obana, Tomomi Yamashita, Makiko Maeda, Naoto Katakami, Hideaki Kaneto, Toru Oka, Issei Komuro, Junichi Azuma, Hiroyuki Nakayama, Yasushi Fujio

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY　Vol. 51　No. 2　p. 207-214　2011/08　Research paper (scientific journal)

Interleukin-6 family cytokines induce endothelial cell differentiation of cardiac Sca-1+cells via STAT3/Pim-1 signaling pathway

Tomohiko Iwakura, Tomomi Mohri, Tatsuto Hamatani, Tomomi Yamashita, Masanori Obana, Akiko Hayama, Kazuki Matsui, Makiko Maeda, Junichi Azuma, Hiroyuki Nakayama, Yasushi Fujio

JOURNAL OF PHARMACOLOGICAL SCIENCES　Vol. 115　p. 96P-96P　2011

Cathelicidin antimicrobial peptide (CAMP) is induced in autoimmune myocarditis and reduces the motility of cardiac fibroblasts

Kazuki Matsui, Tomomi Yamashita, Haruyo Kawaguchi, Tomohiko Iwakura, Masanori Obana, Akiko Hayama, Shiho Murasawa, Kohei Katayama, Momoko Shiragaki, Makiko Maeda, Junichi Azuma, Hiroyuki Nakayama, Yasushi Fujio

JOURNAL OF PHARMACOLOGICAL SCIENCES　Vol. 115　p. 110P-110P　2011

Interleukin-11 exhibits the post-conditioning effects against ischemia reperfusion injury through cardiac STAT3 activation

Masanori Obana, Kaori Miyamoto, Tomohiko Iwakura, Akiko Hayama, Tomomi Yamashita, Shiho Murasawa, Momoko Shiragaki, Makiko Maeda, Junichi Azuma, Hiroyuki Nakayama, Yasushi Fujio

JOURNAL OF PHARMACOLOGICAL SCIENCES　Vol. 115　p. 110P-110P　2011

Cigarette Smoke Extract Induces CYP2B6 through Constitutive Androstane Receptor in Hepatocytes

Ikumi Washio, Makiko Maeda, Chika Sugiura, Ryota Shiga, Mitsuhiro Yoshida, Shinpei Nonen, Yasushi Fujio, Junichi Azuma

DRUG METABOLISM AND DISPOSITION　Vol. 39　No. 1　p. 1-3　2011/01　Research paper (scientific journal)

Pim-1 Kinase is Required for Endothelial Differentiation of Cardiac Stem Cells via STAT3 Signaling Pathway

Tomohiko Iwakura, Tomomi Mohri, Tatsuto Hamatani, Tomomi Yamashita, Masanori Obana, Akiko Hayama, Makiko Maeda, Hiroyuki Nakayama, Issei Komuro, Junichi Azuma, Yasushi Fujio

CIRCULATION　Vol. 122　No. 21　2010/11

The Gene Polymorphisms of CYP2A6 and the Nicotinic Acetylcholine Receptor alpha 4 Subunit Influence Nicotine Dependence, Which is One of the Cardiovascular Risk Factors, in Japanese Smokers

Makiko Maeda, Chieko N. Taniguchi, Masanobu Funamoto, Genta Miura, Tomoko Kubota, Chika Sugiura, Ryota Shiga, Shipei Nonen, Yasushi Fujio, Junichi Azuma

CIRCULATION　Vol. 122　No. 21　2010/11

Therapeutic Activation of Signal Transducer and Activator of Transcription 3 by Interleukin-11 Ameliorates Cardiac Fibrosis After Myocardial Infarction

Masanori Obana, Makiko Maeda, Koji Takeda, Akiko Hayama, Tomomi Mohri, Tomomi Yamashita, Yoshikazu Nakaoka, Issei Komuro, Kiyoshi Takeda, Goro Matsumiya, Junichi Azuma, Yasushi Fujio

CIRCULATION　Vol. 121　No. 5　p. 684-U121　2010/02　Research paper (scientific journal)

Interleukin-11 ameliorates cardiac remodeling after myocardial infarction through STAT3

Masanori Obana, Makiko Maeda, Junichi Azuma, Yasushi Fujio

JOURNAL OF PHARMACOLOGICAL SCIENCES　Vol. 112　p. 74P-74P　2010

Interleukin-11 Attenuates Infarct Size and Improves Ventricular Function in a Canine Heart Model of Ischemia/Reperfusion Injury

Koji Takeda, Goro Matsumiya, Shigeru Miyagawa, Makiko Maeda, Yasushi Fujio, Yoshiki Sawa

CIRCULATION　Vol. 120　No. 18　p. S737-S737　2009/11

Signals Through Glycoprotein 130 Regulate the Endothelial Differentiation of Cardiac Stem Cells

Tomomi Mohri, Yasushi Fujio, Masanori Obana, Tomohiko Iwakura, Koichi Matsuda, Makiko Maeda, Junichi Azuma

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY　Vol. 29　No. 5　p. 754-760　2009/05　Research paper (scientific journal)

IL-6 family cytokines induce IL-10 in cardiac myocytes via STAT3 and ERK1/2 signaling pathway

Tomohiko Iwakura, Yasushi Fujio, Makiko Maeda, Tomomi Mohri, Masanori Obana, Koichi Matsuda, Tomomi Yamashita, Akiko Hayama, Junichi Azuma

JOURNAL OF PHARMACOLOGICAL SCIENCES　Vol. 109　p. 62P-62P　2009

Th17 cells are induced in chronic inflammation after myocardial infarction

Akiko Hayama, Yasushi Fujio, Masanori Obana, Tomomi Mohri, Tomomi Yamashita, Tomohiko Iwakura, Makiko Maeda, Junichi Azuma

JOURNAL OF PHARMACOLOGICAL SCIENCES　Vol. 109　p. 118P-118P　2009

Analyses on the in vivo transdifferentiation of cardiac stem cells into endothelial cell lineage in post-infarct myocardium

Koichi Matsuda, Yasushi Fujio, Tomomi Mohri, Masanori Obana, Tomohiko Iwakura, Tomomi Yamashita, Akiko Hayama, Makiko Maeda, Junichi Azuma

JOURNAL OF PHARMACOLOGICAL SCIENCES　Vol. 109　p. 118P-118P　2009

The infiltration of Th17 cells into myocardium is associated with severity of the inflammation in experimental autoimmune myocarditis (EAM)

Tomomi Yamashita, Yasushi Fujio, Akiko Hayama, Kouichi Matsuda, Masanori Obana, Tomohiko Iwakura, Tornomi Mohri, Makiko Maeda, Junichi Azuma

JOURNAL OF PHARMACOLOGICAL SCIENCES　Vol. 109　p. 117P-117P　2009

Atrogin-1 ubiquitin ligase is upregulated by doxorubicin via p38-MAP kinase in cardiac myocytes

Yasuhiro Yamamoto, Yuki Hoshino, Takashi Ito, Tetsuro Nariai, Tomomi Mohri, Masanori Obana, Nozomi Hayata, Yoriko Uozumi, Makiko Maeda, Yasushi Fujio, Junichi Azuma

CARDIOVASCULAR RESEARCH　Vol. 79　No. 1　p. 89-96　2008/07　Research paper (scientific journal)

Connective tissue growth factor induces cardiac hypertrophy through Akt signaling

Nozomi Hayata, Yasushi Fujio, Yasuhiro Yamamoto, Tomohiko Iwakura, Masanori Obana, Mika Takai, Tomomi Mohri, Shinpei Nonen, Makiko Maeda, Junichi Azuma

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 370　No. 2　p. 274-278　2008/05　Research paper (scientific journal)

MTHFR gene polymorphism is susceptible to diabetic retinopathy but not to diabetic nephropathy in Japanese type 2 diabetic patients

Makiko Maeda, Isamu Yamamoto, Masakatsu Fukuda, Takashi Motomura, Mari Nishida, Shinpei Nonen, Soji Kasayama, Yasushi Fujio, Junichi Azuma

JOURNAL OF DIABETES AND ITS COMPLICATIONS　Vol. 22　No. 2　p. 119-125　2008/03　Research paper (scientific journal)

Adrenergic beta(1) receptor polymorphism (Ser49Gly) is associated with obesity in type II diabetic patients

Shinpei Nonen, Isamu Yamamoto, Jianmin Liu, Makiko Maeda, Takashi Motomura, Tsuyoshi Igarashi, Yasushi Fujio, Junichi Azuma

BIOLOGICAL & PHARMACEUTICAL BULLETIN　Vol. 31　No. 2　p. 295-298　2008/02　Research paper (scientific journal)

治療薬の代謝と薬物相互作用

前田 真貴子

新しい診断と治療のABC 13　p. 335-343　2008　Research paper (scientific journal)

Signals through gp130 mediate the endothelial differentiation in cardiac Sca-1+stem cells

Tomomi Mohri, Yasushi Fujio, Tomohiko Iwakura, Masanori Obana, Koichi Matsuda, Makiko Maeda, Takashi Ito, Yasuhiro Yamamoto, Nozomi Hayata, Akiko Hayama, Tomomi Yamashita, Junichi Azuma

JOURNAL OF PHARMACOLOGICAL SCIENCES　Vol. 106　p. 58P-58P　2008

Skeletal muscle-derived Sca-1+stem cells are differentiated into endothelial cells by Leukemia inhibitory factor

Tomohiko Iwakura, Yasushi Fujio, Makiko Maeda, Tomomi Mohri, Koichi Matsuda, Tomomi Yamashita, Takashi Ito, Yasuhiro Yamamoto, Masanori Obana, Nozomi Hayata, Mika Takai, Akiko Hayama, Yukako Ueno, Haruaki Nobori, Kouhei Yamashita, Junichi Azuma

JOURNAL OF PHARMACOLOGICAL SCIENCES　Vol. 106　p. 99P-99P　2008

Interleukin (IL)-11 ameliorates cardiac remodeling with angiogenic and anti-inflammatory effects in murine myocardial infarction model

Masanori Obana, Makiko Maeda, Yasubito Yamamoto, Takashi Ito, Tomomi Mohri, Tomohiko Iwakura, Nozomi Hayata, Mika Takai, Akiko Hayama, Koichi Matsuda, Kouhei Yamashita, Yasushi Fujio, Juriichi Azuma

JOURNAL OF PHARMACOLOGICAL SCIENCES　Vol. 106　p. 112P-112P　2008

Connective tissue growth factor mediates hypertrophic signals through its C-terminal domain in cultured cardiac myocytes

Nozomi Hayata, Yasushi Fujio, Takashi Ito, Tomomi Mohri, Yasuhiro Yamamoto, Masanori Obana, Tomohiko Iwakura, Mika Takai, Koichi Matsuda, Yukako Ueno, Makiko Maeda, Shinpei Nonen, Junichi Azuma

JOURNAL OF PHARMACOLOGICAL SCIENCES　Vol. 106　p. 120P-120P　2008

Signals through glycoprotein 130 promote the endothelial differentiation of cardiac Sca(-1)+ cells

Tomomi Mohri, Yasushi Fujio, Tomohiko Iwakura, Masanori Obana, Koichi Matsuda, Makiko Maeda, Takashi Ito, Yasuhiro Yamamoto, Nozomi Hayata, Junichi Azuma

CIRCULATION　Vol. 116　No. 16　p. 48-48　2007/10

Interleukin-11 prevents cardiac remodeling after myocardial infarction with Neovascularization in murine model

Masanori Obana, Makiko Maeda, Yasuhiro Yamamoto, Takashi Ito, Tomomi Mohn, Tomohiko Iwakura, Nozomi Hayata, Mika Takai, Akiko Hayama, Koichi Matsuda, Kouhei Yamashita, Yasushi Fujio, Junichi Azuma

CIRCULATION　Vol. 116　No. 16　p. 262-262　2007/10

Gab family proteins are essential for postnatal maintenance of cardiac function via neuregulin-1/ErbB signaling

Yoshikazu Nakaoka, Keigo Nishida, Masahiro Narimatsu, Atsunori Kamiya, Takashi Minami, Hirofumi Sawa, Katsuya Okawa, Yasushi Fujio, Tatsuya Koyama, Makiko Maeda, Manami Sone, Satoru Yamasaki, Yuji Arai, Gou Young Koh, Tatsuhiko Kodama, Hisao Hirota, Kinya Otsu, Toshio Hirano, Naoki Mochizuki

JOURNAL OF CLINICAL INVESTIGATION　Vol. 117　No. 7　p. 1771-1781　2007/07　Research paper (scientific journal)

Identification of cardiac myocytes as the target of interleukin 11, a cardioprotective cytokine

Ryusuke Kimura, Makiko Maeda, Atsushi Arita, Yuichi Oshima, Masanori Obana, Takashi Ito, Yasuhiro Yamamoto, Tomorm Mohri, Tadamitsu Kishimoto, Ichiro Kawase, Yasushi Fujio, Junichi Azuma

CYTOKINE　Vol. 38　No. 2　p. 107-115　2007/05　Research paper (scientific journal)

Interleukin (IL)-11 prevents ischemia/reperfusion (I/R) injury in hearts as a novel card ioprotective cytokine.

Makiko Maeda, Ryusuke Kimura, Atsushi Arita, Masanori Obana, Yasuhiro Yamamoto, Tomomi Mohri, Tomohiko Iwakura, Koichi Mastuda, Takashi Ito, Yasushi Kimura, Yuichi Oshima, Yasushi Fujio, Junichi Azuma

JOURNAL OF PHARMACOLOGICAL SCIENCES　Vol. 103　p. 117P-117P　2007

MTHFR gene polymorphism and diabetic retinopathy

Makiko Maeda, Yasushi Fujio, Junichi Azuma

Current Diabetes Reviews　Vol. 2　No. 4　p. 467-476　2006/11　Research paper (scientific journal)

Cardiac sca-1+cells were differentiated into endothelial cells by leukemia inhibitory factor, a paracrine cytokine

Tomomi Mohh, Yasushi Fujio, Makiko Maeda, Takashi Ito, Tomohiko Iwakura, Yoriko Uozumi, Yasuhiro Yamamoto, Junichi Azuma

CIRCULATION　Vol. 114　No. 18　p. 120-120　2006/10

Interleukin (IL)-11 prevents ischemia/reperfusion injury in hearts as a novel cardioprotective cytokine

Makiko Maeda, Yasushi Fujio, Ryusuke Kimura, Atsushi Arita, Takashi Itoh, Yasuhiro Yamamoto, Tomomi Mohri, Yuichi Oshima, Junich Azuma

CIRCULATION　Vol. 114　No. 18　p. 208-208　2006/10

Atrogin-1 ubiquitin ligase is upregulated by doxorubicin, leading to muscle atrophy in cardiac myocytes

Yasushi Fujio, Yuki Hoshino-Nariai, Yasuhiro Yamamoto, Takashi Ito, Yoriko Uozumi, Tomomi Mohri, Masanori Obana, Tetsurou Nariai, Yasushi Kimura, Makiko Maeda, Junichi Azuma

CIRCULATION　Vol. 114　No. 18　p. 332-332　2006/10

Antisense to cyclin D1 inhibits vascular endothelial growth factor-stimulated growth of vascular endothelial cells: Implication of tumor vascularization

Masayoshi Yasui, Hirofumi Yamamoto, Chew Yee Ngan, Bazarragchaa Damdinsuren, Yurika Sugita, Hiroki Fukunaga, Jinyu Gu, Makiko Maeda, Ichiro Takemasa, Masataka Ikeda, Yasushi Fujio, Mitsugu Sekimoto, Nariaki Matsuura, I. Bernard Weinstein, Morito Monden

CLINICAL CANCER RESEARCH　Vol. 12　No. 15　p. 4720-4729　2006/08　Research paper (scientific journal)

Degradation of transcription factor NFAT5 is induced by doxorubicin exposure in cultured cardiomyocytes

Ito Takashi, Uozumi Yoriko, Maeda Makiko, Yamamoto Yasuhiro, Mohri Tomomi, Fujio Yasushi, Azuma Junichi

ACTA PHARMACOLOGICA SINICA　Vol. 27　p. 140-140　2006/07

Leukemia inhibitory factor induces endothelial differentiation in cardiac Sca-1+stem cells

Mohri Tomomi, Fujio Yasushi, Maeda Makiko, Ito Takashi, Iwakura Tomo-hiko, Oshima Yuichi, Uozumi Yoriko, Yamamoto Yasuhiro, Azuma Junichi

ACTA PHARMACOLOGICA SINICA　Vol. 27　p. 183-183　2006/07

Myogenic differentiation induces taurine transporter in association with taurine-mediated cytoprotection in skeletal muscles

Y Uozumi, T Ito, Y Hoshino, T Mohri, M Maeda, K Takahashi, Y Fujio, J Azuma

BIOCHEMICAL JOURNAL　Vol. 394　No. Pt 3　p. 699-706　2006/03　Research paper (scientific journal)

Leukemia inhibitory factor induces endothelial differentiation in cardiac stem cells

T Mohri, Y Fujio, M Maeda, T Ito, T Iwakura, Y Oshima, Y Uozumi, M Segawa, H Yamamoto, T Kishimoto, J Azuma

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 281　No. 10　p. 6442-6447　2006/03　Research paper (scientific journal)

CYP2A6 polymorphisms are associated with nicotine dependence and influence withdrawal symptoms in smoking cessation

Kubota T, Nakajima-Taniguchi C, Fukuda T, Funamoto M, Maeda M, Tange E, Ueki R, Kawashima K, Hara H, Fujio Y, Azuma J

Pharmacogenomics Journal　Vol. 6　No. 2　p. 115-119　2006

TauT gene expression is regulated by TonEBP and plays a role in cell survival

Takashi Ito, Yasushi Fujio, Yoriko Uozumi, Takahisa Matsuda, Makiko Maeda, Kyoko Takahashi, Junichi Azuma

TAURINE 6　Vol. 583　p. 91-98　2006　Research paper (scientific journal)

Platelet activating factor induces cytoskeletal reorganization through Rho family pathway in THP-1 macrophages

C Sumita, M Yamane, T Matsuda, M Maeda, T Nariai, Y Fujio, J Azuma

FEBS LETTERS　Vol. 579　No. 18　p. 4038-4042　2005/07　Research paper (scientific journal)

Pioglitazone induces plasma platelet activating factor-acetylhydrolase and inhibits platelet activating factor-mediated cytoskeletal reorganization in macrophage.

Sumita C, Maeda M, Fujio Y, Kim J, Fujitsu J, Kasayama S, Yamamoto I, Azuma J

Biochimica et biophysica acta　Vol. 1673　No. 3　p. 115-121　2004/08　Research paper (scientific journal)

Signals through gp130 upregulate Wnt5a and contribute to cell adhesion in cardiac myocytes

Y Fujio, T Matsuda, Y Oshima, M Maeda, T Mohri, T Ito, T Takatani, M Hirata, Y Nakaoka, R Kimura, T Kishimoto, J Azuma

FEBS LETTERS　Vol. 573　No. 1-3　p. 202-206　2004/08　Research paper (scientific journal)

Homocysteine induces vascular endothelial growth factor expression in differentiated THP-1 macrophages.

Maeda M, Yamamoto I, Fujio Y, Azuma J

Biochimica et biophysica acta　Vol. 1623　No. 1　p. 41-46　2003/09　Research paper (scientific journal)

MTHFR gene polymorphism as a risk factor for diabetic retinopathy in type 2 diabetic patients without serum creatinine elevation

M Maeda, Yamamoto, I, M Fukuda, M Nishida, J Fujitsu, S Nonen, T Igarashi, T Motomura, M Inaba, Y Fujio, J Azuma

DIABETES CARE　Vol. 26　No. 2　p. 547-548　2003/02

Diabetic retinopathy possibly results from poor blood sugar control associated with MTHFR gene polymorphism in type 2 diabetic patients - Response to Yoshioka et al.

Maeda M, Yamamoto I, Fukuda M, Nishida M, Fujitsu J, Nonen S, Igarashi T, Motomura T, Inaba M, Fujio Y, Azuma J

Diabetes Care　Vol. 26　No. 6　p. 1948-1948　2003