顔写真

PHOTO

Komagawa Shinsuke
駒川　晋輔
Komagawa Shinsuke
駒川　晋輔
Graduate School of Pharmaceutical Sciences　Drug Innovation Center, Specially Appointed Assistant Professor (Full Time)

keyword Organometallic Chemistry，Medicinal Chemistry，Organic Chemistry

Research History 4

  1. 2016/04 - Present
    Osaka University　Graduate School of Pharmaceutical Sciences Drug Innovation Center

  2. 2013/04 - 2016/03
    Tokushima Bunri University　Faculty of Pharmaceutical Sciences at Kagawa Campus

  3. 2011/04 - 2013/03
    The University of Tokyo　Graduate School of Pharmaceutical Sciences

  4. 2009/04 - 2011/03
    RIKEN

Education 3

  1. Tokyo University of Science　Graduate School of Science　Department of Chemistry

    2006/04 - 2009/03

  2. Tokyo University of Science　Special Training Course for Teacher　Department of Chemistry

    2004/04 - 2006/03

  3. Tokyo University of Science　Faculty of Science, Division 1　Department of Chemistry

    2000/04 - 2004/03

Professional Memberships 3

  1. 有機合成化学協会

  2. 日本化学会

  3. 日本薬学会

Research Areas 2

  1. Life sciences / Pharmaceuticals - chemistry and drug development /

  2. Nanotechnology/Materials / Synthetic organic chemistry /

Papers 29

  1. Oxidative Coupling of Hydroquinone Derivatives with Olefins to Dihydrobenzofurans.

    Yoshinari Sawama, Keiichiro Nakajima, Takaaki Aijima, Miyu Mae, Shinsuke Komagawa, Hiroki Nakata, Hironao Sajiki, Shuji Akai

    Chemical & pharmaceutical bulletin　Vol. 72　No. 6　p. 566-569　2024　Research paper (scientific journal)

  2. Construction of Functionalized ortho‐Naphthoquinone Methides via Site‐Selective Ring Opening of 1‐Siloxy‐1,4‐epoxy‐1,4‐dihydronaphthalenes

    Takaaki Aijima, Shinsuke Komagawa, Shuji Akai, Yoshinari Sawama

    Advanced Synthesis & Catalysis　Vol. 365　No. 22　p. 3981-3986　2023/10/12　Research paper (scientific journal)

    Publisher: Wiley

  3. Restoration of Cardiac Myosin Light Chain Kinase Ameliorates Systolic Dysfunction by Reducing Superrelaxed Myosin

    Tatsuro Hitsumoto, Osamu Tsukamoto, Ken Matsuoka, Junjun Li, Li Liu, Yuki Kuramoto, Shuichiro Higo, Shou Ogawa, Noboru Fujino, Shohei Yoshida, Hidetaka Kioka, Hisakazu Kato, Hideyuki Hakui, Yuki Saito, Chisato Okamoto, Hijiri Inoue, Jo Hyejin, Kyoko Ueda, Takatsugu Segawa, Shunsuke Nishimura, Yoshihiro Asano, Hiroshi Asanuma, Akiyoshi Tani, Riyo Imamura, Shinsuke Komagawa, Toshio Kanai, Masayuki Takamura, Yasushi Sakata, Masafumi Kitakaze, Jun Ichi Haruta, Seiji Takashima

    Circulation　Vol. 147　No. 25　p. 1902-1918　2023/06/20　Research paper (scientific journal)

  4. Experimental and Computational Investigation of Facial Selectivity Switching in Nickel–Diamine–Acetate-Catalyzed Michael Reactions

    Yoshihiro Sohtome, Shinsuke Komagawa, Ayako Nakamura, Daisuke Hashizume, Sylvain Lectard, Mai Akakabe, Yoshitaka Hamashima, Masanobu Uchiyama, Mikiko Sodeoka

    The Journal of Organic Chemistry　2023/02/22　Research paper (scientific journal)

    Publisher: American Chemical Society (ACS)

  5. Stille coupling via C-N bond cleavage

    Dong Yu Wang, Masatoshi Kawahata, Ze Kun Yang, Kazunori Miyamoto, Shinsuke Komagawa, Kentaro Yamaguchi, Chao Wang, Masanobu Uchiyama

    Nature Communications　Vol. 7　2016/09/30　Research paper (scientific journal)

  6. Direct Hydroxylation and Amination of Arenes via Deprotonative Cupration

    Noriyuki Tezuka, Kohei Shimojo, Keiichi Hirano, Shinsuke Komagawa, Kengo Yoshida, Chao Wang, Kazunori Miyamoto, Tatsuo Saito, Ryo Takita, Masanobu Uchiyama

    Journal of the American Chemical Society　Vol. 138　No. 29　p. 9166-9171　2016/07/27　Research paper (scientific journal)

  7. A highly regio- and stereoselective selenoxide elimination of 1,2-bis[4-(trimethylsilyl)phenylseleno]alkanes to give (E)-alkenyl selenoxides and its mechanistic study

    Asami Tarao, Aya Niki, Shinsuke Komagawa, Kenji Arimitsu, Hitomi Uchimoto, Ikuo Kawasaki, Kentaro Yamaguchi, Kiyoharu Nishide

    ChemistrySelect　Vol. 1　No. 2　p. 189-194　2016　Research paper (scientific journal)

  8. High-resolution X-ray structure of methyl salicylate, a time-honored oily medicinal drug, solved by crystalline sponge method

    Masatoshi Kawahata, Shinsuke Komagawa, Kazuaki Ohara, Makoto Fujita, Kentaro Yamaguchi

    Tetrahedron Letters　Vol. 57　No. 41　p. 4633-4636　2016　Research paper (scientific journal)

  9. How and Why Does Ni0 Promote Smooth Etheric C-O Bond Cleavage and C-C Bond Formation? A Theoretical Study

    Hiroyuki Ogawa, Hiroki Minami, Takashi Ozaki, Shinsuke Komagawa, Chao Wang, Masanobu Uchiyama

    Chemistry - A European Journal　Vol. 21　No. 40　p. 13904-13908　2015/09/01　Research paper (scientific journal)

  10. Control of a Chiral Property of a Calix[3]aramide: The Racemization Suppressed by Intramolecular Cyclic Hydrogen Bonds and DMSO-H<inf>2</inf>O System-Induced Spontaneous Resolution

    Kosuke Katagiri, Shinsuke Komagawa, Masanobu Uchiyama, Kentaro Yamaguchi, Isao Azumaya

    Organic Letters　Vol. 17　No. 15　p. 3650-3653　2015/08/07　Research paper (scientific journal)

  11. Structural effects in lithiocuprate chemistry: The elucidation of reactive pentametallic complexes

    Philip J. Harford, Andrew J. Peel, Joseph P. Taylor, Shinsuke Komagawa, Paul R. Raithby, Thomas P. Robinson, Masanobu Uchiyama, Andrew E.H. Wheatley

    Chemistry - A European Journal　Vol. 20　No. 14　p. 3908-3912　2014/04　Research paper (scientific journal)

  12. Diastereoselective deprotonative metalation of chiral ferrocene derived acetals and esters using mixed lithium-cadmium and lithium-zinc combinations

    Gandrath Dayaker, Aare Sreeshailam, D. Venkata Ramana, Floris Chevallier, Thierry Roisnel, Shinsuke Komagawa, Ryo Takita, Masanobu Uchiyama, Palakodety Radha Krishna, Florence Mongin

    Tetrahedron　Vol. 70　No. 12　p. 2102-2117　2014/03/25　Research paper (scientific journal)

  13. Mechanistic origin of chemo-and regioselectivity of nickel-catalyzed [3 + 2 + 2] cyclization reaction

    Shinsuke Komagawa, Chao Wang, Keiji Morokuma, Shinichi Saito, Masanobu Uchiyama

    Journal of the American Chemical Society　Vol. 135　No. 39　p. 14508-14511　2013/10/02　Research paper (scientific journal)

  14. Amidocuprates for directed ortho cupration: Structural study, mechanistic investigation, and chemical requirements

    Shinsuke Komagawa, Shinya Usui, Joanna Haywood, Philip J. Harford, Andrew E.H. Wheatley, Yotaro Matsumoto, Keiichi Hirano, Ryo Takita, Masanobu Uchiyama

    Angewandte Chemie - International Edition　Vol. 51　No. 48　p. 12081-12085　2012/11/26　Research paper (scientific journal)

  15. Synthesis of both enantiomers of ferrocene[1,2-c]1H-quinolin-2-one by diastereoselective deproto-zincation of sugar-derived ferrocene esters

    Aare Sreeshailam, Gandrath Dayaker, D. Venkata Ramana, Floris Chevallier, Thierry Roisnel, Shinsuke Komagawa, Ryo Takita, Masanobu Uchiyama, Palakodety Radha Krishna, Florence Mongin

    RSC Advances　Vol. 2　No. 18　p. 7030-7032　2012/08/28　Research paper (scientific journal)

  16. Finding reaction pathways for multicomponent reactions: The passerini reaction is a four-component reaction

    Satoshi Maeda, Shinsuke Komagawa, Masanobu Uchiyama, Keiji Morokuma

    Angewandte Chemie - International Edition　Vol. 50　No. 3　p. 644-649　2011/01/17　Research paper (scientific journal)

  17. Reaction pathway of methylenation of carbonyl compounds with bis(iodozincio)methane

    Mutsumi Sada, Shinsuke Komagawa, Masanobu Uchiyama, Masami Kobata, Tsuyoshi Mizuno, Kiitiro Utimoto, Koichiro Oshima, Seijiro Matsubara

    Journal of the American Chemical Society　Vol. 132　No. 49　p. 17452-17458　2010/12/15　Research paper (scientific journal)

  18. Homoleptic zincate-promoted room-temperature halogen-metal exchange of bromopyridines

    Nguyet Trang Thanh Chau, Maxime Meyer, Shinsuke Komagawa, Floris Chevallier, Yves Fort, Masanobu Uchiyama, Florence Mongin, Philippe C. Gros

    Chemistry - A European Journal　Vol. 16　No. 41　p. 12425-12433　2010/11/02　Research paper (scientific journal)

  19. 1,4-Addition of Bis(iodozincio)methane to α,β-Unsaturated ketones: Chemical and theoretical/computational studies

    Mutsumi Sada, Taniyuki Furayama, Shinsuke Komagawa, Masanobu Uchiyama, Seijiro Matsubara

    Chemistry - A European Journal　Vol. 16　No. 34　p. 10474-10481　2010/09/10　Research paper (scientific journal)

  20. Deprotonative metalation of substituted benzenes and heteroaromatics using amino/alkyl mixed lithium-zinc combinations

    Katia Snégaroff, Shinsuke Komagawa, Floris Chevallier, Philippe C. Gros, Stéphane Golhen, Thierry Roisnel, Masanobu Uchiyama, Florence Mongin

    Chemistry - A European Journal　Vol. 16　No. 27　p. 8191-8201　2010/07/19　Research paper (scientific journal)

  21. Lithium cadmate-mediated deprotonative metalation of anisole: Experimental and computational study

    Katia Snégaroff, Shinsuke Komagawa, Mitsuhiro Yonehara, Floris Chevallier, Philippe C. Gros, Masanobu Uchiyama, Florence Mongin

    Journal of Organic Chemistry　Vol. 75　No. 9　p. 3117-3120　2010/05/07　Research paper (scientific journal)

  22. Nickel-catalyzed [3+2+2] cycloaddition of ethyl cyclopropylideneacetate and heteroatom-substituted alkynes: Application to selective three-component reaction with 1,3-diynes

    Ryu Yamasaki, Natsuki Terashima, Ikuo Sotome, Shunsuke Komagawa, Shinichi Saito

    Journal of Organic Chemistry　Vol. 75　No. 2　p. 480-483　2010/01/15　Research paper (scientific journal)

  23. Thermal and catalytic isomerization of exomethylenecycloheptadienes. Experimental and theoretical studies

    Yukiko Fukusaki, Jun Miyazaki, Isao Azumaya, Kosuke Katagiri, Shinsuke Komagawa, Ryu Yamasaki, Shinichi Saito

    Tetrahedron　Vol. 65　No. 51　p. 10631-10636　2009/12/19　Research paper (scientific journal)

  24. Synthesis of Vinylcycloheptadienes by the Nickel-Catalyzed Three-Component [3 + 2 + 2] Cocyclization. Application to the Synthesis of Polycyclic Compounds (vol 74, pg 3323, 2009)

    Shinsuke Komagawa, Kouhei Takeuchi, Ikuo Sotome, Isao Azumaya, Hyuma Masu, Ryu Yamasaki, Shinichi Saito

    JOURNAL OF ORGANIC CHEMISTRY　Vol. 74　No. 15　p. 5766-5766　2009/08

  25. Synthesis of vinylcycloheptadienes by the nickel-catalyzed three-component [3 + 2 + 2] cocyclization. Application to the synthesis of polycyclic compounds

    Shinsuke Komagawa, Kouhei Takeuchi, Ikuo Sotome, Isao Azumaya, Hyuma Masu, Ryu Yamasaki, Shinichi Saito

    Journal of Organic Chemistry　Vol. 74　No. 9　p. 3323-3329　2009/05/01　Research paper (scientific journal)

  26. Ni-catalyzed [3+2+2] cycloaddition of ethyl cyclopropylideneacetate and 1,3-diynes. Application to the three-component cycloaddition

    Ryu Yamasaki, Ikuo Sotome, Shunsuke Komagawa, Isao Azumaya, Hyuma Masu, Shinichi Saito

    Tetrahedron Letters　Vol. 50　No. 10　p. 1143-1145　2009/03/11　Research paper (scientific journal)

  27. Nickel-catalyzed intermolecular [3 + 2 + 2] cocyclization of ethyl cyclopropylideneacetate and alkynes. Synthesis of seven-membered carbocycles

    Shinichi Saito, Shinsuke Komagawa, Isao Azumaya, Manami Masuda

    Journal of Organic Chemistry　Vol. 72　No. 24　p. 9114-9120　2007/11/23　Research paper (scientific journal)

  28. Nickel-catalyzed three-component [3+2+2] cocyclization of ethyl cyclopropylideneacetate and alkynes - Selective synthesis of multisubstituted cycloheptadienes

    Shinsuke Komagawa, Shinichi Saito

    Angewandte Chemie - International Edition　Vol. 45　No. 15　p. 2446-2449　2006/04　Research paper (scientific journal)

  29. Nickel-catalyzed intermolecular [3 + 2 + 2] cocyclization of ethyl cyclopropylideneacetate and alkynes

    Shinichi Saito, Manami Masuda, Shinsuke Komagawa

    Journal of the American Chemical Society　Vol. 126　No. 34　p. 10540-10541　2004/09/01　Research paper (scientific journal)

Misc. 32

  1. LUBAC ubiquitin ligase complex and linear ubiquitination facilitate cytoplasmic aggregation of amyotrophic lateral sclerosis (ALS)-associated TDP-43

    寺脇正剛, ZHANG Qiang, 及川大輔, LIN Bangzhong, 布村一人, 駒川晋輔, 臼杵克之助, 徳永文稔

    日本分子生物学会年会プログラム・要旨集(Web)　Vol. 44th　2021

  2. Computational Study of Solvent Effects on Racemization of Optically Pure Propargyl Alcohols

    牧野雅義, 駒川晋輔, 井川貴詞, 赤井周司

    日本薬学会年会要旨集(Web)　Vol. 140th　2020

  3. 構造展開ユニットから見るアカデミア低分子創薬

    中川啓, 阪上昌浩, 松村宏治, 吉田耕三, 藤井晋太郎, 里章平, 駒川晋輔, 東雅之, 春田純一

    日本薬学会年会要旨集(CD-ROM)　Vol. 138th　2018

  4. 1,2-ビスセレノアルカンを用いた位置および立体選択的脱離反応とその計算化学的考察

    多羅尾あさみ, 仁木亜弥, 駒川晋輔, 萬代咲, 有光健治, 内本ひとみ, 川崎郁勇, 山口健太郎, 西出喜代治

    日本薬学会年会要旨集(CD-ROM)　Vol. 136th　2016

  5. 環状pybox化合物の合成

    日生下哲一郎, 駒川晋輔, 川幡正俊, 山口健太郎

    日本薬学会年会要旨集(CD-ROM)　Vol. 136th　2016

  6. 「結晶スポンジ法」による医薬品の3次元構造解析

    明石貴吉, 川幡正俊, 駒川晋輔, 小原一朗, 藤田誠, 山口健太郎

    日本薬学会年会要旨集(CD-ROM)　Vol. 135th　2015

  7. 結晶スポンジ法による結晶構造解析・基礎

    川幡正俊, 明石貴吉, 坂井貴紘, 駒川晋輔, 小原一朗, 山口健太郎

    日本分析化学会有機微量分析研究懇談会・計測自動制御学会力学量計測部会合同シンポジウム講演要旨集　Vol. 82nd-98th　2015

  8. 結晶スポンジ法による油状薬物の結晶構造解析・応用

    森彩, 明石貴吉, 坂井貴紘, 駒川晋輔, 小原一朗, 川幡正俊, 山口健太郎

    日本分析化学会有機微量分析研究懇談会・計測自動制御学会力学量計測部会合同シンポジウム講演要旨集　Vol. 82nd-98th　2015

  9. イオン化プローブを指向した環状pybox化合物の合成

    駒川晋輔, 日生下哲一郎, 上乃満, 川幡正俊, 山口健太郎

    反応と合成の進歩シンポジウム講演要旨集　Vol. 41st　2015

  10. 結晶スポンジ法による香料および油状薬物の構造解析

    駒川晋輔, 川幡正俊, 小原一朗, 片桐幸輔, 藤田誠, 山口健太郎

    日本薬学会年会要旨集(CD-ROM)　Vol. 134th　2014

  11. ホスフィノカリックス[3]アミドにおけるキラリティー固定と光学分割

    片桐幸輔, 石田馨, 駒川晋輔, 富永昌英, 山口健太郎, 東屋功

    日本化学会講演予稿集　Vol. 94th　No. 3　2014

  12. 銅アート錯体を用いた芳香環への位置/化学選択的な水酸基およびアミノ基導入反応の開発

    下條弘平, 下條弘平, 駒川晋輔, 滝田良, 内山真伸, 内山真伸

    基礎有機化学討論会要旨集　Vol. 25th　2014

  13. 銅アート錯体を用いた芳香環への位置/化学選択的な水酸基導入反応の開発

    下條弘平, 駒川晋輔, 滝田良, 内山真伸

    日本化学会講演予稿集　Vol. 94th　No. 4　2014

  14. 銅アート錯体を用いる芳香環Directed ortho Cuprationの反応機構と直接的水酸基導入反応への応用

    滝田良, 下條弘平, 駒川晋輔, 内山真伸, 内山真伸

    反応と合成の進歩シンポジウム講演要旨集　Vol. 39th　2013

  15. アート錯体を用いた亜鉛フタロシアニンの合成

    駒川晋輔, 吉川晶子, 滝田良, 村中厚哉, 内山真伸

    日本化学会講演予稿集　Vol. 92nd　No. 4　2012

  16. 亜鉛アート錯体を用いたフタロシアニン合成法の開発

    駒川晋輔, 吉川晶子, 吉川晶子, 滝田良, 村中厚哉, 内山真伸, 内山真伸

    日本薬学会年会要旨集　Vol. 132nd　No. 2　2012

  17. 銅アート錯体を用いた芳香環の直接官能基化反応と理論的考察

    駒川晋輔, 臼井伸也, 滝田良, 内山真伸, 内山真伸

    日本薬学会年会要旨集　Vol. 131st　No. 2　2011

  18. 二亜鉛種を用いたメチレン化反応の理論計算による解析

    駒川晋輔, 内山真伸, 定むつみ, 松原誠二郎

    日本化学会講演予稿集　Vol. 90th　No. 4　2010

  19. 二亜鉛種を用いた1,2-付加及び1,4-付加反応の理論解析

    駒川晋輔, 古山渓行, 内山真伸, 定むつみ, 松原誠二郎

    次世代を担う有機化学シンポジウム講演要旨集　Vol. 8th　2010

  20. 多成分反応の遷移構造の自動的な系統探索

    前田理, 駒川晋輔, 内山真伸, 内山真伸, 諸熊奎治, 諸熊奎治

    分子科学討論会講演プログラム&要旨(Web)　Vol. 4th　2010

  21. Functionalized Alkynes as Substrate for [2+2+3] Cocylization with Ethyl Cyclopropylideneacetate

    山崎龍, 五月女郁夫, 寺島奈津希, 駒川晋輔, 桝飛雄真, 東屋功, 斉藤慎一

    日本化学会講演予稿集　Vol. 89th　No. 2　2009

  22. Efficient Synthesis of Seven-membered Rings by the Nickel-catalyzed Cycloaddition Reactions

    KOMAGAWA Shinsuke, YAMASAKI Ryu, SAITO Shinichi

    Journal of Synthetic Organic Chemistry, Japan　Vol. 66　No. 10　p. 974-982　2008/10/01

    Publisher: The Society of Synthetic Organic Chemistry, Japan

  23. ORGN 635-Synthesis of polycyclic cycloheptadienes by the nickel-catalyzed [3+2+2] cycloaddition and sequential [4+2] cycloaddition

    Shinsuke Komagawa, Kouhei Takeuchi, Ikuo Sotome, Ryu Yamasaki, Shinichi Saito

    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY　Vol. 236　2008/08　Research paper, summary (international conference)

  24. ニッケル触媒下における電子欠乏性メチレンシクロプロパンと共役エンインとの[3+2+2]型環化付加反応及びその応用

    駒川晋輔, 竹内浩平, 五月女郁夫, 山崎龍, 斎藤慎一

    日本化学会講演予稿集　Vol. 88th　No. 2　2008

  25. [3+2+2]/[4+2]型連続環化付加反応を用いた多環性中員環化合物の合成

    駒川晋輔, 竹内浩平, 五月女郁夫, 山崎龍, 斎藤慎一, 桝飛雄真

    反応と合成の進歩シンポジウム講演要旨集　Vol. 34th　2008

  26. ORGN 343-Cycloaddition reactions of ethyl cyclopropylideneacetate in the presence of Ni(0) catalysts: A new buliding block for the synthesis of medium-sized rings

    Shinichi Saito, Shinsuke Komagawa, Ikuo Sotome, Takahiro Yoshizawa, Natsuki Terashima, Yukiko Fukusaki, Kyotaro Maeda

    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY　Vol. 234　2007/08　Research paper, summary (international conference)

  27. ニッケル触媒下における電子欠乏性メチレンシクロプロパンと共役ジインを用いる[3+2+2]型環化付加反応

    五月女郁夫, 駒川晋輔, 東屋功, 桝飛雄真, 斎藤慎一

    日本化学会講演予稿集　Vol. 87th　No. 2　2007

  28. ニッケル触媒下における電子欠乏性メチレンシクロプロパンとアルキンの3成分[3+2+2]型環化付加反応

    駒川晋輔, 斎藤慎一

    日本薬学会年会要旨集　Vol. 125th　No. 4　2005

  29. Synthesis of 6,7-bicyclic Compounds by the Nickel(0)-Catalyzed[3+2+2] Cycloaddition between Electron-deficient methylenecyclopropanes and Diynes

    前田京太郎, 駒川晋輔, 斎藤慎一

    日本化学会講演予稿集　Vol. 85th　No. 2　2005

  30. ニッケル触媒下における電子欠乏性メチレンシクロプロパンの新反応:効率的な新規7員環構築法

    斎藤慎一, 増田麻奈美, 駒川晋輔, 竹内浩平, 前田京太郎, 東屋功, 加藤貴子

    反応と合成の進歩シンポジウム講演要旨集　Vol. 31st　2005

  31. Novel Nickel(0)-Catalyzed [3+2+2] Cycloaddition between Alkylidenecyclopropane and Alkynes

    駒川晋輔, 増田麻奈美, 斎藤慎一

    日本化学会講演予稿集　Vol. 84th　No. 2　2004

  32. ニッケル触媒下における電子欠乏性メチレンシクロプロパンとアルキンを用いる新規7員環構築反応

    駒川晋輔, 増田麻奈美, 斎藤慎一, 東屋功, 加藤貴子

    反応と合成の進歩シンポジウム講演要旨集　Vol. 30th　2004