顔写真

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KIM MEE-HAE
金 美海
KIM MEE-HAE
金 美海
Institutional repository
Graduate School of Engineering　Department of Biotechnology, Associate Professor
Institutional repository

Education 2

  1. 大阪大学大学院工学研究科博士課程応用生物工学（バイオテクノロジ英語特別コース）専攻

    2004/10 - 2007/09

  2. 大阪大学大学院工学研究科修士課程応用生物工学（バイオテクノロジ英語特別コース）専攻

    2002/10 - 2004/09

Professional Memberships 6

  1. The International Society for Stem Cell Research (ISSCR)

  2. Tissue Engineering & Regenerative Medicine International Society

  3. THE JAPANESE SOCIETY FOR BIOMATERIALS

  4. THE JAPANESE SOCIETY FOR REGENERATIVE MEDICINE

  5. THE SOCIETY OF CHEMICAL ENGINEERS, JAPAN

  6. The Society for Biotechnology, Japan

Research Areas 1

  1. Manufacturing technology (mechanical, electrical/electronic, chemical engineering) / Applied biofunctional and bioprocess engineering /

Awards 6

  1. Outstanding Contribution in Reviewing

    Mee-Hae Kim　2017

  2. 第38回照井賞

    金 美海　第67回日本生物工学会　2016/10

  3. The Johnson & Johnson Global Career Award

    金 美海　第11回日本再生医療学会　2012/06

  4. ベストポスター賞

    金 美海　第10回日本再生医療学会　2011/03

  5. Young Investigator Award (YIA)

    金 美海　The 2nd International Symposium of Materials on Regenerative Medicine (ISOMRM)　2010/08

  6. The YABEC Award for The Most Powerful Poster Presentation賞受賞

    金 美海　Young Asian Biochemical Engineers' Community (YABEC)　2004/09

Papers 62

  1. Stable and efficient generation of functional iPSC-derived neural progenitor cell rosettes through regulation of collective cell-cell behavior

    Mee-Hae Kim, Naruchit Thanuthanakhun, Masahiro Kino-oka

    Frontiers in Bioengineering and Biotechnology　Vol. 11　2024/01/10　Research paper (scientific journal)

    Publisher: Frontiers Media SA

  2. Growth prolongation of human induced pluripotent stem cell aggregate in three-dimensional suspension culture system by addition of botulinum hemagglutinin

    Riku Yamamoto, Ryo Sakakibara, Mee-Hae Kim, Yukako Fujinaga, Masahiro Kino-oka

    Journal of Bioscience and Bioengineering　2023/12　Research paper (scientific journal)

    Publisher: Elsevier BV

  3. A simple tool for the synchronous differentiation of human induced pluripotent stem cells into pancreatic progenitors

    Mee‐Hae Kim, Naruchit Thanuthanakhun, Masahiro Kino‐oka

    Biotechnology Journal　2023/11/13　Research paper (scientific journal)

    Publisher: Wiley

  4. An in vitro culture platform to study the extracellular matrix remodeling potential of human mesenchymal stem cells

    Mee-Hae Kim, Shao Ying Tan, Kenichi Yamahara, Masahiro Kino-oka

    Acta Biomaterialia　2023/08　Research paper (scientific journal)

    Publisher: Elsevier BV

  5. An in vitro culture platform for studying the effect of collective cell migration on spatial self-organization within induced pluripotent stem cell colonies

    Mee-Hae Kim, Masaki Kuroda, Ding Ke, Naruchit Thanuthanakhun, Masahiro Kino-oka

    Journal of Biological Engineering　Vol. 17　No. 1　2023/03/30　Research paper (scientific journal)

    Publisher: Springer Science and Business Media {LLC}

  6. Novel strategy to improve hepatocyte differentiation stability through synchronized behavior-driven mechanical memory of iPSCs.

    Mee-Hae Kim, Naruchit Thanuthanakhun, Masahiro Kino-Oka

    Biotechnology and bioengineering　2022/11/12　Research paper (scientific journal)

    Publisher: Wiley

  7. Cell Behavioral Dynamics as a Cue in Optimizing Culture Stabilization in the Bioprocessing of Pluripotent Stem Cells.

    Naruchit Thanuthanakhun, Mee-Hae Kim, Masahiro Kino-Oka

    Bioengineering (Basel, Switzerland)　Vol. 9　No. 11　p. 669-669　2022/11/09　Research paper (scientific journal)

    Publisher: MDPI AG

  8. Effect of Rho-Associated Kinase Inhibitor on Growth Behaviors of Human Induced Pluripotent Stem Cells in Suspension Culture.

    Takaki Matsumoto, Mee-Hae Kim, Masahiro Kino-Oka

    Bioengineering (Basel, Switzerland)　Vol. 9　No. 11　p. 613-613　2022/10/25　Research paper (scientific journal)

    Publisher: MDPI AG

  9. Effect of initial seeding density on cell behavior-driven epigenetic memory and preferential lineage differentiation of human iPSCs.

    Mee-Hae Kim, Naruchit Thanuthanakhun, Shun Fujimoto, Masahiro Kino-Oka

    Stem cell research　Vol. 56　p. 102534-102534　2021/09/07　Research paper (scientific journal)

  10. Mechanobiological conceptual framework for assessing stem cell bioprocess effectiveness

    Mee-Hae Kim, Masahiro Kino-oka

    Biotechnology and Bioengineering　2021/08/30　Research paper (scientific journal)

    Publisher: Wiley

  11. Novel approach to enhance aggregate migration-driven epigenetic memory which induces cardiomyogenic differentiation on a dendrimer-immobilized surface.

    Mee-Hae Kim, Fitria Dwi Ayuningtyas, Masahiro Kino-Oka

    Journal of bioscience and bioengineering　2021/07/17　Research paper (scientific journal)

  12. The impact of culture dimensionality on behavioral epigenetic memory contributing to pluripotent state of iPS cells

    Naruchit Thanuthanakhun, Masahiro Kino-oka, Suparerk Borwornpinyo, Yuzuru Ito, Mee-Hae Kim

    Journal of Cellular Physiology　Vol. 236　No. 7　p. 4985-4996　2021/07　Research paper (scientific journal)

    Publisher: Wiley

  13. Muscle lineage switching by migratory behaviour-driven epigenetic modifications of human mesenchymal stem cells on a dendrimer-immobilized surface

    Fitria Dwi Ayuningtyas, Mee-Hae Kim, Masahiro Kino-oka

    Acta Biomaterialia　Vol. 106　p. 170-180　2020/04　Research paper (scientific journal)

    Publisher: Elsevier BV

  14. Suppression of time-dependent decay by controlling the redox balance of human induced pluripotent stem cells suspended in a cryopreservation solution

    Masashi Kagihiro, Kazuhiro Fukumori, Ikki Horiguchi, Mee-Hae Kim, Masahiro Kino-oka

    Biochemical Engineering Journal　Vol. 155　p. 107465-107465　2020/03　Research paper (scientific journal)

  15. Bioengineering Considerations for a Nurturing Way to Enhance Scalable Expansion of Human Pluripotent Stem Cells

    Mee‐Hae Kim, Masahiro Kino‐oka

    Biotechnology Journal　Vol. 15　No. 4　2020/01/20　Research paper (scientific journal)

    Publisher: Wiley

  16. Maintenance of Neurogenic Differentiation Potential in Passaged Bone Marrow-Derived Human Mesenchymal Stem Cells Under Simulated Microgravity Conditions

    Chaiyong Koaykul, Mee-Hae Kim, Yumi Kawahara, Louis Yuge, Masahiro Kino-oka

    Stem Cells and Development　Vol. 28　No. 23　p. 1552-1561　2019/12/01　Research paper (scientific journal)

    Publisher: Mary Ann Liebert Inc

  17. Designing a blueprint for next‐generation stem cell bioprocessing development

    Mee‐Hae Kim, Masahiro Kino‐oka

    Biotechnology and Bioengineering　Vol. 117　No. 3　p. 832-843　2019/11/28　Research paper (scientific journal)

    Publisher: Wiley

  18. Alterations in Nuclear Lamina and the Cytoskeleton of Bone Marrow-Derived Human Mesenchymal Stem Cells Cultured Under Simulated Microgravity Conditions

    Chaiyong Koaykul, Mee-Hae Kim, Yumi Kawahara, Louis Yuge, Masahiro Kino-oka

    Stem Cells and Development　Vol. 28　No. 17　p. 1167-1176　2019/09/01　Research paper (scientific journal)

    Publisher: Mary Ann Liebert Inc

  19. Maintenance of an undifferentiated state of human-induced pluripotent stem cells through botulinum hemagglutinin-mediated regulation of cell behavior.

    Eri Shuzui, Mee-Hae Kim, Keisuke Azuma, Yukako Fujinaga, Masahiro Kino-Oka

    Journal of bioscience and bioengineering　Vol. 127　No. 6　p. 744-751　2019/06　Research paper (scientific journal)

  20. Effect of migratory behaviors on human induced pluripotent stem cell colony formation on different extracellular matrix proteins

    Jessica Chang, Mee-Hae Kim, Eviryanti Agung, Sho Senda, Masahiro Kino-oka

    Regenerative Therapy　Vol. 10　p. 27-35　2019/06　Research paper (scientific journal)

    Publisher: Elsevier BV

  21. Role of cell-secreted extracellular matrix formation in aggregate formation and stability of human induced pluripotent stem cells in suspension culture

    Mee-Hae Kim, Kazuhiro Takeuchi, Masahiro Kino-oka

    Journal of Bioscience and Bioengineering　Vol. 127　No. 3　p. 372-380　2019/03　Research paper (scientific journal)

    Publisher: Elsevier BV

  22. Anomalous cell migration triggers a switch to deviation from the undifferentiated state in colonies of human induced pluripotent stems on feeder layers

    Eri Shuzui, Mee-Hae Kim, Masahiro Kino-oka

    Journal of Bioscience and Bioengineering　Vol. 127　No. 2　p. 246-255　2019/02　Research paper (scientific journal)

    Publisher: Elsevier BV

  23. A Novel Strategy for Simple and Robust Expansion of Human Pluripotent Stem Cells Using Botulinum Hemagglutinin

    Mee-Hae Kim, Masahiro Kino-oka

    Advances in Experimental Medicine and Biology　p. 19-29　2018/10/25　Part of collection (book)

    Publisher: Springer Singapore

  24. Comparison of growth kinetics between static and dynamic cultures of human induced pluripotent stem cells

    Yuma Kato, Mee-Hae Kim, Masahiro Kino-oka

    Journal of Bioscience and Bioengineering　Vol. 125　No. 6　p. 736-740　2018/06/01　Research paper (scientific journal)

    Publisher: Elsevier B.V.

  25. Botulinum hemagglutinin-mediated in situ break-up of human induced pluripotent stem cell aggregates for high-density suspension culture

    Suman C. Nath, Tomohiro Tokura, Mee-Hae Kim, Masahiro Kino-oka

    Biotechnology and Bioengineering　Vol. 115　No. 4　p. 910-920　2018/04/01　Research paper (scientific journal)

    Publisher: John Wiley and Sons Inc.

  26. Maintenance of human chondrogenic phenotype on a dendrimer-immobilized surface for an application of cell sheet engineering

    Sopita Wongin, Saranatra Waikakul, Pojchong Chotiyarnwong, Wanwipa Siriwatwechakul, Masahiro Kino-oka, Mee-Hae Kim, Kwanchanok Viravaidya-Pasuwat

    BMC Biotechnology　Vol. 18　No. 1　2018/03/14　Research paper (scientific journal)

    Publisher: BioMed Central Ltd.

  27. A Simple and Robust Method for Culturing Human-Induced Pluripotent Stem Cells in an Undifferentiated State Using Botulinum Hemagglutinin

    Mee-Hae Kim, Yoshifumi Matsubara, Yukako Fujinaga, Masahiro Kino-oka

    Biotechnology Journal　Vol. 13　No. 2　p. 1700384 (1)-1700384(10)　2018/02/01　Research paper (scientific journal)

    Publisher: Wiley-VCH Verlag

  28. Bioprocessing Strategies for Pluripotent Stem Cells Based on Waddington's Epigenetic Landscape

    Mee-Hae Kim, Masahiro Kino-oka

    Trends in Biotechnology　Vol. 36　No. 1　p. 89-104　2018/01/01　Research paper (scientific journal)

    Publisher: Elsevier Ltd

  29. Chondrogenesis and hypertrophy in response to aggregate behaviors of human mesenchymal stem cells on a dendrimer-immobilized surface

    Sopita Wongin, Yuuki Ogawa, Mee-Hae Kim, Kwanchanok Viravaidya-Pasuwat, Masahiro Kino-oka

    BIOTECHNOLOGY LETTERS　Vol. 39　No. 8　p. 1253-1261　2017/08　Research paper (scientific journal)

  30. Phenotypic heterogeneity of human retinal pigment epithelial cells in passaged cell populations

    Rie Sonoi, Mee-Hae Kim, Kenta Yamada, Masahiro Kino-oka

    JOURNAL OF BIOSCIENCE AND BIOENGINEERING　Vol. 124　No. 2　p. 227-233　2017/08　Research paper (scientific journal)

  31. Botulinum hemagglutinin-mediated selective removal of cells deviating from the undifferentiated state in hiPSC colonies

    Mee-Hae Kim, Yo Sugawara, Yukako Fujinaga, Masahiro Kino-oka

    SCIENTIFIC REPORTS　Vol. 7　No. 1　2017/03　Research paper (scientific journal)

  32. Development of an automated chip culture system with integrated on-line monitoring for maturation culture of retinal pigment epithelial cells

    Mee-Hae Kim, Masakazu Inamori, Masakazu Akechi, Hirohisa Abe, Yoshiki Yagi, Masahiro Kino-oka

    AIMS Bioengineering　Vol. 4　No. 4　p. 402-417　2017　Research paper (scientific journal)

    Publisher: American Institute of Mathematical Sciences (AIMS)

  33. Migration-driven aggregate behaviors of human mesenchymal stem cells on a dendrimer-immobilized surface direct differentiation toward a cardiomyogenic fate commitment

    Yuuki Ogawa, Mee-Hae Kim, Masahiro Kino-oka

    JOURNAL OF BIOSCIENCE AND BIOENGINEERING　Vol. 122　No. 5　p. 627-632　2016/11　Research paper (scientific journal)

  34. Facilitation of uniform maturation of human retinal pigment epithelial cells through collective movement in culture

    Rie Sonoi, Mee-Hae Kim, Masahiro Kino-oka

    JOURNAL OF BIOSCIENCE AND BIOENGINEERING　Vol. 121　No. 2　p. 220-226　2016/02　Research paper (scientific journal)

  35. Changes in human mesenchymal stem cell behaviors on dendrimer-immobilized surfaces due to mediation of fibronectin adsorption and assembly

    Yuuki Ogawa, Mee-Hae Kim, Masahiro Kino-Oka

    JOURNAL OF BIOSCIENCE AND BIOENGINEERING　Vol. 120　No. 6　p. 709-714　2015/12　Research paper (scientific journal)

  36. Maintenance of an undifferentiated state of human induced pluripotent stem cells through migration-dependent regulation of the balance between cell-cell and cell-substrate interactions

    Mee-Hae Kim, Masahiro Kino-oka

    JOURNAL OF BIOSCIENCE AND BIOENGINEERING　Vol. 119　No. 6　p. 617-622　2015/06　Research paper (scientific journal)

  37. Locational heterogeneity of maturation by changes in migratory behaviors of human retinal pigment epithelial cells in culture

    Rie Sonoi, Mee-Hae Kim, Masahiro Kino-oka

    JOURNAL OF BIOSCIENCE AND BIOENGINEERING　Vol. 119　No. 1　p. 107-112　2015/01　Research paper (scientific journal)

  38. Maintenance of undifferentiated state of human induced pluripotent stem cells through cytoskeleton-driven force acting to secreted fibronectin on a dendrimer-immobilized surface

    Mee-Hae Kim, Masahiro Kino-oka

    JOURNAL OF BIOSCIENCE AND BIOENGINEERING　Vol. 118　No. 6　p. 716-722　2014/12　Research paper (scientific journal)

  39. Switching between self-renewal and lineage commitment of human induced pluripotent stem cells via cell-substrate and cell-cell interactions on a dendrimer-immobilized surface

    Mee-Hae Kim, Masahiro Kino-oka

    BIOMATERIALS　Vol. 35　No. 22　p. 5670-5678　2014/07　Research paper (scientific journal)

  40. Influence of surface topography on the human epithelial cell response to micropatterned substrates with convex and concave architectures

    Mee Hae Kim, Yoshiko Sawada, Masahito Taya, Masahiro Kino-oka

    Journal of Biological Engineering　Vol. 8　No. 1　2014/06/19　Research paper (scientific journal)

  41. Kinetic Analysis of Deviation From the Undifferentiated State in Colonies of Human Induced Pluripotent Stem Cells on Feeder Layers

    Mee-Hae Kim, Eri Masuda, Masahiro Kino-oka

    BIOTECHNOLOGY AND BIOENGINEERING　Vol. 111　No. 6　p. 1128-1138　2014/06　Research paper (scientific journal)

  42. Directed differentiation of human mesenchymal stem cells toward a cardiomyogenic fate commitment through formation of cell aggregates

    Mee Hae Kim, Yuuki Ogawa, Koji Yamada, Masahito Taya, Masahiro Kino-oka

    Biochemical Engineering Journal　Vol. 84　No. 15　p. 53-58　2014/03/15　Research paper (scientific journal)

  43. Cell tracking under high confluency conditions by candidate cell region detection-based association approach

    Ryoma Bise, Yoshitaka Maeda, Mee-Hae Kim, Masahiro Kino-Oka

    Proceedings of the IASTED International Conference on Biomedical Engineering, BioMed 2013　p. 554-561　2013　Research paper (international conference proceedings)

  44. Preferential growth of skeletal myoblasts and fibroblasts in co-culture on a dendrimer-immobilized surface

    Masahiro Kino-oka, Jongpill Kim, Kazue Kurisaka, Mee-Hae Kim

    JOURNAL OF BIOSCIENCE AND BIOENGINEERING　Vol. 115　No. 1　p. 96-99　2013/01　Research paper (scientific journal)

  45. Analysis of locality of early-stage maturation in confluent state of human retinal pigment epithelial cells

    Mee-Hae Kim, Rie Sonoi, Kenta Yamada, Masakazu Inamori, Masahiro Kino-oka

    JOURNAL OF BIOSCIENCE AND BIOENGINEERING　Vol. 113　No. 6　p. 778-781　2012/06　Research paper (scientific journal)

  46. Comprehension of terminal differentiation and dedifferentiation of chondrocytes during passage cultures

    Masrina Mohd Nadzir, Masahiro Kino-oka, Nao Maruyama, Yasuaki Sato, Mee Hae Kim, Katsura Sugawara, Masahito Taya

    Journal of Bioscience and Bioengineering　Vol. 112　No. 4　p. 395-401　2011/10　Research paper (scientific journal)

  47. Characterization of spatial cell distribution in multilayer sheet of human keratinocytes through a stereoscopic cell imaging system

    Mee Hae Kim, Naoki Tsubakino, Shogo Kagita, Masahito Taya, Masahiro Kino-oka

    Journal of Bioscience and Bioengineering　Vol. 112　No. 3　p. 289-291　2011/09　Research paper (scientific journal)

  48. Embryonic stem cells maintain an undifferentiated state on dendrimer-immobilized surface with D-glucose display

    Shohreh Mashayekhan, Mee Hae Kim, Masahiro Kino-Oka, Jun Ichi Miyazaki, Masahito Taya

    Polymers　Vol. 3　No. 4　p. 2078-2087　2011　Research paper (scientific journal)

  49. Cardiomyogenic induction of human mesenchymal stem cells by altered Rho family GTPase expression on dendrimer-immobilized surface with d-glucose display

    Mee Hae Kim, Masahiro Kino-oka, Nao Maruyama, Atsuhiro Saito, Yoshiki Sawa, Masahito Taya

    Biomaterials　Vol. 31　No. 30　p. 7666-7677　2010/10　Research paper (scientific journal)

  50. 幹細胞から心筋細胞分化誘導可能なグルコース提示型培養面の開発

    金 美海, 圓山 尚, 紀ノ岡 正博, 田谷 正仁

    化学工学会 研究発表講演要旨集　Vol. 2010　p. 118-118　2010

    Publisher: 公益社団法人 化学工学会

  51. Dendrimer-Immobilized Culture Surface as a Tool to Promote Aggregate Formation of Anchorage-Dependent Cells

    Mee-Hae Kim, Masahiro Kino-oka, Jun-ichi Miyazaki, Masahito Taya

    ANIMAL CELL TECHNOLOGY: BASICS & APPLIED ASPECTS　Vol. 16　p. 57-63　2010　Research paper (international conference proceedings)

  52. Designing culture surfaces based on cell anchoring mechanisms to regulate cell morphologies and functions

    M. H. Kim, M. Kino-oka, M. Taya

    Biotechnology Advances　Vol. 28　No. 1　p. 7-16　2010/01　Research paper (scientific journal)

  53. Myogenic induction of human mesenchymal stem cells by culture on dendrimer-immobilized surface with d-glucose display

    Mee Hae Kim, Masahiro Kino-oka, Atsuhiro Saito, Yoshiki Sawa, Masahito Taya

    Journal of Bioscience and Bioengineering　Vol. 109　No. 1　p. 55-61　2010/01　Research paper (scientific journal)

  54. Morphological regulation and aggregate formation of rabbit chondrocytes on dendrimer-immobilized surfaces with d-glucose display

    Mee Hae Kim, Masahiro Kino-oka, Yoshiki Morinaga, Yoshiko Sawada, Masaya Kawase, Kiyohito Yagi, Masahito Taya

    Journal of Bioscience and Bioengineering　Vol. 107　No. 2　p. 196-205　2009/02　Research paper (scientific journal)

  55. Enrichment of undifferentiated mouse embryonic stem cells on a culture surface with a glucose-displaying dendrimer

    Shohreh Mashayekhan, Mee Hae Kim, Satsuki Miyazaki, Fumi Tashiro, Masahiro Kino-oka, Masahito Taya, Jun ichi Miyazaki

    Biomaterials　Vol. 29　No. 31　p. 4236-4243　2008/11　Research paper (scientific journal)

  56. Glucose Transporter Mediation Responsible for Morphological Changes of Human Epithelial Cells on Glucose-Displayed Surfaces

    Kim Mee-Hae, Kino-oka Masahiro, Kawase Masaya, Yagi Kiyohito, Taya Masahito

    Journal of Fermentation Technology　Vol. 105　No. 4　p. 319-326　2008

    Publisher: The Society for Biotechnology, Japan

  57. Synergistic Effect of D-Glucose and Epidermal Growth Factor Display on Dynamic Behaviors of Human Epithelial Cells

    Mee Hae Kim, Masahiro Kino-oka, Masaya Kawase, Kiyohito Yagi, Masahito Taya

    Journal of Bioscience and Bioengineering　Vol. 104　No. 5　p. 428-431　2007/11　Research paper (scientific journal)

  58. Morphological regulation of rabbit chondrocytes on glucose-displayed surface

    Masahiro Kino-oka, Yoshiki Morinaga, Mee Hae Kim, Yasunori Takezawa, Masaya Kawase, Kiyohito Yagi, Masahito Taya

    Biomaterials　Vol. 28　No. 9　p. 1680-1688　2007/03　Research paper (scientific journal)

  59. Response of human epithelial cells to culture surfaces with varied roughnesses prepared by immobilizing dendrimers with/without d-glucose display

    Mee Hae Kim, Masahiro Kino-oka, Masaya Kawase, Kiyohito Yagi, Masahito Taya

    Journal of Bioscience and Bioengineering　Vol. 103　No. 2　p. 192-199　2007/02　Research paper (scientific journal)

  60. Construction of an electro-enzymatic bioreactor for the production of (R)-mandelate from benzoylformate

    MH Kim, SE Yun

    BIOTECHNOLOGY LETTERS　Vol. 26　No. 1　p. 21-26　2004/01　Research paper (scientific journal)

  61. Dendrimer-immobilized culture surface as a tool to evaluate formation of cellular cytoskeleton of anchorage-dependent cells

    Norihiko Hata, Mee Hae Kim, Katsuhiro Isoda, Masahiro Kino-Oka, Masaya Kawase, Kiyohito Yagi, Masahito Taya

    Journal of Bioscience and Bioengineering　Vol. 97　No. 4　p. 233-238　2004　Research paper (scientific journal)

  62. Enhanced Production of Benzoylformate Reductase in Enterococcus faecalis under Oxidative Stress Established by Natural Electron Carriers

    SANG-HO BAIK, PAN-KI CHO, MEE-HAE KIM, SEI-EOKYUN

    Journal of Microbiology and Biotechnology　Vol. 13　No. 1　p. 104-109　2003/02/01　Research paper (scientific journal)

Misc. 67

  1. Development of New Technologies for Differentiation Stabilization of Pluripotent Stem Cells

    金美海, 紀ノ岡正博, 紀ノ岡正博

    日本再生医療学会総会(Web)　Vol. 23rd　2024

  2. 高密度コラーゲン塗布面を用いたヒト間葉系幹細胞の培養における細胞外小胞の生産能の検討

    奥田愛理, 金美海, 紀ノ岡正博

    日本再生医療学会総会(Web)　Vol. 23rd　2024

  3. ヒト間葉系幹細胞の播種密度が免疫抑制能におけるエピジェネティクに及ぼす影響

    津村進夢, 金美海, 紀ノ岡正博, 紀ノ岡正博

    日本再生医療学会総会(Web)　Vol. 23rd　2024

  4. 細胞外マトリックスのリモデリング能を評価する幹細胞ポテンシーアッセイの開発

    中田光星, TAN Shao Ying, 金美海, 紀ノ岡正博, 紀ノ岡正博

    日本再生医療学会総会(Web)　Vol. 23rd　2024

  5. ヒトiPS細胞から肝細胞への分化誘導の安定化技術の開発

    金美海, 金美海, 紀ノ岡正博, 紀ノ岡正博

    日本再生医療学会総会(Web)　Vol. 22nd　2023

  6. ヒトiPS細胞からさまざまな細胞へのロバストな分化誘導法の開発

    金美海, 紀ノ岡正博, 紀ノ岡正博

    日本再生医療学会総会(Web)　Vol. 22nd　2023

  7. Development of platform to study extracellular matrix remodeling potential of human mesenchymal stem cells

    TAN Shao Ying, KIM Mee-Hae, 紀ノ岡正博

    日本生物工学会大会講演要旨集　Vol. 75th　2023

  8. Development of highly efficient and stable hepatocyte differentiation induction technology from human iPS cells

    KIM Mee-Hae, 紀ノ岡正博

    日本生物工学会大会講演要旨集　Vol. 75th　2023

  9. メチルグリオキサールによるヒト間葉系幹細胞の増殖促進

    TORNG Ang Kai, 金美海, 紀ノ岡正博

    日本再生医療学会総会(Web)　Vol. 21st　2022

  10. ヒト間葉系幹細胞の培養におけるエクソソームの特性の検討

    木山実優, 金美海, 紀ノ岡正博

    日本再生医療学会総会(Web)　Vol. 21st　2022

  11. コラーゲン塗布面上でのヒト間葉系幹細胞の骨格形成とmatrix metalloproteinase-1活性の検討

    TAN Shao Ying, 金美海, 紀ノ岡正博

    日本再生医療学会総会(Web)　Vol. 21st　2022

  12. Effect of Methylglyoxal on Growth Promotion of Human Mesenchymal Stem Cells.

    ANG Kai Torng, KIM Mee-Hae, 紀ノ岡正博

    日本生物工学会大会講演要旨集　Vol. 74th　2022

  13. Investigation of Extracellular Matrix Remodeling Effect of Human Mesenchymal Stem Cells on Collagen-Coated Surface

    TAN Shao Ying, KIM Mee-Hae, 紀ノ岡正博

    日本生物工学会大会講演要旨集　Vol. 74th　2022

  14. Elucidation of the mechanism of epithelial-mesenchymal transition in the process of hiPSC differentiation and development of efficient differentiation induction method

    坂谷優奈, KIM Mee-Hae, 紀ノ岡正博

    日本生物工学会大会講演要旨集　Vol. 74th　2022

  15. Production of extracellular vesicles containing exosomes in human mesenchymal stem cell cultures

    木山実優, KIM Mee-Hae, 紀ノ岡正博

    日本生物工学会大会講演要旨集　Vol. 74th　2022

  16. Elucidation of aggregate formation process in suspension culture of human iPS cells

    KIM Mee-Hae, 紀ノ岡正博

    日本結合組織学会学術大会抄録集　Vol. 52nd　2020

  17. ROCK inhibitorの添加がhiPS細胞集塊の細胞外マトリックスに与える影響

    松本崇揮, KIM Mee-Hae, 紀ノ岡正博

    日本生物工学会大会講演要旨集　Vol. 71st　2019

  18. ボツリヌス毒素複合体の無毒成分ヘマグルチニン(HA)を利用したiPS細胞の大量培養技術と最小化HAの開発

    阿松翔, 阿松翔, 金美海, 松村拓大, 紀ノ岡正博, 藤永由佳子

    日本分子生物学会年会プログラム・要旨集(Web)　Vol. 42nd　2019

  19. ヘマグルチニンを用いるヒトiPS細胞の高密度培養法

    金 美海, 紀ノ岡 正博

    B&I バイオサイエンスとインダストリー　Vol. 76　No. 6　p. 481-483　2018/11

    Publisher: （一財）バイオインダストリー協会

  20. ボツリヌス菌由来ヘマグルチニンを用いたヒトiPS細胞の大量増幅のための培養作法の開発

    金 美海, 紀ノ岡 正博

    生物工学会誌　Vol. 96　No. 6　p. 333-336　2018/06

  21. 密着結合タンパクの機能解析に基づいた新規網膜毒性評価系の構築

    金美海, 紀ノ岡正博

    HAB研究機構学術年会プログラム・要旨集　Vol. 24th　2017

  22. ヒトiPS細胞のコロニー形成機構の解明とクローン培養系の構築

    金美海, 近藤伸彦, 紀ノ岡正博

    再生医療　Vol. 16　2017

  23. 細胞自らが作る足場環境に応答した間葉系幹細胞挙動の変化

    小川祐樹, 金美海, 紀ノ岡正博

    再生医療　Vol. 15　2016

  24. 変異型ボツリヌス菌由来のヘマグルチニンを用いた効率よいヒトiPS細胞逸脱細胞の除去法の構築

    金美海, 藤永由佳子, 紀ノ岡正博

    再生医療　Vol. 15　2016

  25. ボツリヌス菌由来Hemagglutininを用いたヒトiPS細胞の高密度懸濁培養法の確立

    山本陸, 都倉知浩, 都倉知浩, NATH Suman Chandra, KIM Mee-Hae, 紀ノ岡正博

    日本生物工学会大会講演要旨集　Vol. 68th　2016

  26. ヒトiPS細胞の継代培養中発生する逸脱細胞の簡便な除去法の構築

    KIM Mee-Hae, 松原佳史, 紀ノ岡正博

    日本生物工学会大会講演要旨集　Vol. 68th　2016

  27. Development of culture process for stem cell differentiation through regulation of Rho family signaling

    Kim Mee-Hae

    Vol. 94　No. 3　p. 117-123　2016

    Publisher: 日本生物工学会

  28. ボツリヌス菌由来のヘマグルチニンを用いたヒトiPS細胞の未分化を逸脱した細胞の除去

    金美海, 松原佳史, 紀ノ岡正博

    再生医療　Vol. 14　2015

  29. 1P-236 Effect of migration on deviation from undifferentiated state of human iPS cells

    Shuzui Eri, Kim Mee-Hae, Kino-oka Masahiro

    Vol. 67　p. 147-147　2015

    Publisher: 日本生物工学会

  30. 1P-235 Development of culture method for removal of cells deviated from the undifferentiated state in colonies of hiPSCs using Botulinum Haemagglutinin

    Kim Mee-Hae, Kino-oka Masahiro

    Vol. 67　p. 147-147　2015

    Publisher: 日本生物工学会

  31. 1P-238 Elucidation of mechanism for regulating cell fate decision inside hiPS aggregate

    Inoue Keita, Kim Mee-Hae, Kino-oka Masahiro

    Vol. 67　p. 148-148　2015

    Publisher: 日本生物工学会

  32. 2A-Dp01 Development of culture process for stem cell differentiation through regulation of Rho family signaling

    Kim Mee-Hae

    Vol. 67　p. 174-174　2015

    Publisher: 日本生物工学会

  33. 細胞核密度と密着結合を指標とした網膜色素上皮細胞の成熟度評価法の開発

    稲森雅和, 金美海, 堂之前義文, 武尾英哉, 紀ノ岡正博

    再生医療　Vol. 13　2014

  34. デンドリマー培養面を利用したヒトiPS細胞の未分化維持～特集 iPS細胞とバイオマテリアル

    金 美海, 紀ノ岡 正博

    バイオマテリアル-生体材料　Vol. 31　No. 3　p. 154-157　2013/08

  35. コンフレント細胞分化度評価のための細胞画像情報からの動的積算マップ法(MapIQ)

    加藤竜司, 梶浦圭一, 蟹江慧, 本多裕之, 金美海, 稲森雅和, 紀ノ岡正博, 加藤竜司

    再生医療　Vol. 12　2013

  36. 密着結合を指標としたコンフルエント状態のヒト網膜色素上皮細胞の成熟度評価

    稲森雅和, 東瀬戸大志, 金美海, 堂之前義文, 武尾英哉, 紀ノ岡正博

    化学工学会年会研究発表講演要旨集(CD-ROM)　Vol. 78th　2013

  37. ヒト網膜色素上皮細胞の成熟培養における培養領域制限の影響

    東瀬戸大志, 稲森雅和, 阿部浩久, 明地将一, 堂之前義文, 武尾英哉, 金美海, 紀ノ岡正博

    化学工学会秋季大会研究発表講演要旨集(CD-ROM)　Vol. 45th　2013

  38. 3P-236 Evaluation for undifferentiation of passaged hiPSCs on dendrimer-immobilized surface

    Kim Mee-Hae, Kino-oka Masahiro

    Vol. 65　p. 247-247　2013

    Publisher: 日本生物工学会

  39. 3P-235 Analysis of derivation from undifferentiation of human induced pluripotent stem cells during passage cultures

    Matsubara Yoshifumi, Masuda Eri, Iga Tomoyo, Kim Mee-Hae, Kino-oka Masahiro

    Vol. 65　p. 247-247　2013

    Publisher: 日本生物工学会

  40. 3P-237 Influence of dendrimer-immobilized surface on the motility of human mesenchymal stem cells

    Ogawa Yuuki, Kim Mee-Hae, Kino-oka Masahiro

    Vol. 65　p. 247-247　2013

    Publisher: 日本生物工学会

  41. 4Ba02 Kinetic analysis of "de-undifferentiation" in colony of human induced pluripotent stem cells

    NOZAWA Yuta, MASUDA Eri, KIM Mee-Hae, KINO-OKA Masahiro

    Vol. 64　p. 184-184　2012

    Publisher: 日本生物工学会

  42. Regulation of cytoskeletal formation culture surface to induce cellular differentiation

    金 美海, 紀ノ岡 正博

    医学のあゆみ　Vol. 238　No. 13　p. 1176-1180　2011/09

    Publisher: 医歯薬出版

  43. 集塊形成過程の異なるヒト間葉系幹細胞に対する心筋分化の比較

    小川祐樹, 金美海, 紀ノ岡正博

    再生医療　Vol. 10　2011

  44. グルコース提示型デンドリマー面における不死化網膜色素上皮細胞の形態制御

    稲森雅和, 金美海, 紀ノ岡正博

    再生医療　Vol. 10　2011

  45. 1Gp07 Cell mobility accumulation map for stable and quantitative analysis of cellular differentiation rate

    Kato Ryuji, Kajiura Keiichi, Kanie Kei, Kim Mee-Hae, Kino-oka Masahiro, Honda Hiroyuki

    Vol. 63　p. 50-50　2011

    Publisher: 日本生物工学会

  46. 2Gp18 Behavior analysis of undifferentiated and differentiated cells in hiPS colony

    MASUDA Eri, KIM Mee-Hae, KINO-OKA Masahiro

    Vol. 63　p. 165-165　2011

    Publisher: 日本生物工学会

  47. 2Gp09 Population balance of myoblast cells by culture on dendrimer-immobilized surface with D-glucose display

    KIM Jongpill, KURISAKA Kazue, KIM Mee-Hae, KINO-OKA Masahiro

    Vol. 63　p. 163-163　2011

    Publisher: 日本生物工学会

  48. 2Gp20 Evaluation of differentiation state in confluent culture of human retinal pigment epithelial cells

    Kim Mee-Hae, Sonoi Rie, Yamada Kenta, Inamori Masakazu, Kino-oka Masahiro

    Vol. 63　p. 165-165　2011

    Publisher: 日本生物工学会

  49. ヒト間葉系幹細胞の接着性細胞集塊の形成と心筋細胞への新規分化誘導法の確立

    金美海, 紀ノ岡正博, 田谷正仁, 齋藤充弘, 澤芳樹

    再生医療　Vol. 9　2010

  50. 細胞の骨組みを変える培養面の設計と分化制御への展開

    紀ノ岡 正博, 金 美海, 田谷 正仁

    化学工学会 研究発表講演要旨集　Vol. 2010　p. 487-487　2010

    Publisher: 公益社団法人 化学工学会

  51. 3P-2096 Differentiation of human mesenchymal stem cells through different processes of cell a aggregate formation

    OGAWA Yuuki, KIM Mee-Hae, KINO-OKA Masahiro

    Vol. 22　p. 172-172　2010

    Publisher: 日本生物工学会

  52. 2P-2090 Dynamic cell behavior in myoblast sheet

    ODA Masashi, KIM Mee-Hae, KINO-OKA Masahiro

    Vol. 22　p. 133-133　2010

    Publisher: 日本生物工学会

  53. 2Kp12 Differentiation of human mesenchymal stem cells by variation in cytoskeletal formation

    MARUYAMA Nao, KIM Mee-hae, KINO-OKA Masahiro, TAYA Masahito, SAITO Atsuhiro, SAWA Yoshiki

    日本生物工学会大会講演要旨集　Vol. 21　p. 160-160　2009/08/25

    Publisher: The Society for Biotechnology, Japan

  54. 細胞足場タンパク制御による幹細胞の分化誘導

    KIM Mee-Hae, 圓山尚, 紀ノ岡正博, 田谷正仁, 齋藤充弘, 澤芳樹

    日本バイオマテリアル学会大会予稿集　Vol. 31st　2009

  55. 2Kp11 Myogenic induction of human mesenchymal stem cells by culture on dendrimer-immobilized surface with D-glucose display

    Kim Mee-Hae, Maruyama Nao, Kino-oka Masahiro, Taya Masahito, Saito Atsuhiro, Sawa Yoshiki

    Vol. 21　p. 159-159　2009

    Publisher: 日本生物工学会

  56. D-グルコース提示面による細胞形態変化の機構解析と細胞集塊形成培養への応用

    金 美海, 紀ノ岡 正博, Mashayekhan Shoreh, 宮崎 純一, 田谷 正仁

    化学工学会 研究発表講演要旨集　Vol. 2008　p. 301-301　2008

    Publisher: 公益社団法人 化学工学会

  57. Enhancement of cell migration in culture of human epithelial cells on surface with EGF and D-glucose display

    M.-H. Kim, M. Kino-oka, M. Kawase, K. Yagi, M. Taya

    TISSUE ENGINEERING　Vol. 13　No. 7　p. 1689-1690　2007/07　Research paper, summary (international conference)

  58. 2F09-1 Mechanism of chondrocyte aggregation on D-glucose-displayed surface

    SAWADA Yoshiko, KIM Mee-Hae, KINO-OKA Masahiro, KAWASE Masaya, YAGI Kiyohito, TAYA Masahito

    Vol. 19　p. 137-137　2007

    Publisher: 日本生物工学会

  59. ヒト上皮細胞培養における基底層安定性の評価

    鍵田 祥吾, 金 美海, 紀ノ岡 正博, 田谷 正仁

    化学工学会 研究発表講演要旨集　Vol. 2007　p. 330-330　2007

    Publisher: 公益社団法人 化学工学会

  60. 2K09-1 Elucidation of mechanism of cell extension on D-glucose-displayed surface

    KIM,MEE-HAE, KINO-OKA,Masahiro, KAWASE,Masaya, YAGI,Kiyohito, TAYA,Masahito

    Vol. 平成18年度　2006/08/03

    Publisher: 日本生物工学会

  61. 2K09-3 Epithelial sheet formation on EGF/D-glucose-displayed surface

    KINO-OKA Masahiro, KIM Mee-Hae, KAWASE Masaya, YAGI Kiyohito, TAYA Masahito

    Vol. 18　p. 198-198　2006

    Publisher: 日本生物工学会

  62. 2K09-2 Morphological regulation of chondrocyte cells by using D-glucosedisplayed dendrimer surface

    SAWADA Yoshiko, KIM Mee-Hae, KINO-OKA Masahiro, KAWASE Masaya, YAGI Kiyohito, TAYA Masahito

    Vol. 18　p. 198-198　2006

    Publisher: 日本生物工学会

  63. 1H15-5 Morphological change of chondrocyte cells by using glucose-displayed surface

    MORINAGA Yoshiki, KIM Mee-hae, TAKEZAWA Yasunori, KINO-OKA Masahiro, KAWASE Masaya, YAGI Kiyohito, TAYA Masahito

    Vol. 17　p. 216-216　2005

    Publisher: 日本生物工学会

  64. 1H16-3 Epithelial sheet formation on EGF/D-glucose-displayed surface

    KINO-OKA Masahiro, MA Zhe, KIM Mee-Hae, MANABE Masafumi, KAWASE Masaya, YAGI Kiyohito, TAYA Masahito

    Vol. 17　p. 216-216　2005

    Publisher: 日本生物工学会

  65. 軟骨細胞の分化能維持を目指した細胞形態制御面の開発

    森永 義樹, 金 美海, Brooks John, 紀ノ岡 正博, 田谷 正仁, 川瀬 雅也, 八木 清仁

    化学工学会 研究発表講演要旨集　Vol. 2005　p. 324-324　2005

    Publisher: 公益社団法人 化学工学会

  66. 3F12-3 Controlling conformation of chondrocytes by using dendrimer-modified culture surface

    MORINAGA Yoshiki, KIM Mee-hae, KINO-OKA Masahiro, KAWASE Masaya, YAGI Kiyohito, TAYA Masahito

    Vol. 16　p. 194-194　2004

    Publisher: 日本生物工学会

  67. Dendrimer-modified culture surface as a tool to evaluate formation of cellular cytoskeleton of keratinocytes

    Hata Norihiko, Kim Mee Hae, Kinooka Masahiro, Kawase Masaya, Yagi Kiyohito, Taya Masahito

    Vol. 15　p. 91-91　2003

    Publisher: 日本生物工学会

Publications 5

  1. Novel Biomaterials for Regenerative Medicine: Advances in Experimental Medicine and Biology

    金 美海

    Springer Nature Pub Co.　2018/05

  2. 細胞・生体分子の固定化と機能発現

    金 美海

    シーエムシー出版　2018/05

  3. 再生医療規制の動向と製品開発および産業化の注意点

    紀ノ岡正博, 金 美海

    （株）情報機構　2015/03

  4. “Protocol of cardiomyogenic induction of hMSCs on dendrimer-immobilized surfaces displaying with D-glucose”, A Manual for Differentiation of Bone Marrow-Derived Stem Cells to Specific Cell Types,Vol.8

    KIM MEE-HAE

    World Scientific Publishing Co. Pte. Ltd　2014

  5. 医学のあゆみ

    金美海, 紀ノ岡正博

    医歯薬出版(株)　2011/09

Presentations 5

  1. Study of human mesenchymal stem cell behaviors on isotropic gravity

    Mee-Hae Kim

    5thTERMIS World Congress　2018/09/07

  2. Development of bioprocessing strategies for stem cells based on Waddington’s epigenetic landscape

    Mee-Hae Kim

    KSBB Fall Meeting and International Symposium　2017/10/27

  3. ヒト幹細胞の挙動制御に基づく未分化維持・分化誘導手法の開発

    金 美海

    幹細胞の培養法・培養工学のためのコンソーシアム第一回シンポジウム　2016/10/16

  4. Designing culture microenvironments to direct stem-cell fate in the regulation of cell behaviors

    Mee-Hae Kim, Masahiro Kino-oka

    Joint symposium with Asian Federation of Biotechnology, Initiated Speech, TERMIS-AP 2016 Conference　2016

  5. 幹細胞の足場タンパク発現制御に基づく分化誘導プロセスの開発

    金 美海

    第67回日本生物工学会大会 照井賞受賞講演　2015/10/27

Industrial Property Rights 5

  1. 多能性幹細胞の増殖を促進するための組成物、及び多能性幹細胞の増殖促進方法

    紀ノ岡 正博, 金 美海, 藤永 由佳子

    出願日:2016/12/20

  2. 変異型ヘマグルチニン複合体タンパク質、及びそれを用いた多能性を有する幹細胞の培養方法

    紀ノ岡 正博, 金 美海, 藤永 由佳子, 菅原 庸

    出願日:2015/06/29

  3. マイクロチップ反応装置

    明地 将一, 阿部 浩久, 紀ノ岡 正博, 金 美海, 稲森 雅和

    出願日:2013/05/24

  4. 多能性(pluripotency)を有する幹細胞の培養方法

    紀ノ岡 正博, 金 美海, 藤永 由佳子, 菅原 庸

    出願日:2013/12/26

  5. 多能性(pluripotency)を有する幹細胞の培養方法

    紀ノ岡 正博, 金 美海, 藤永 由佳子, 菅原 庸

    特許第6112514号

    出願日:2013/12/26

Social Activities 3

  • [Bioengineering] Special Issue on Stem Cell Bioprocessing and Tissue Reconstruction

    2022/06/01 - Present

  • Journal of Bioscience and Biotechnology

    2021/05/01 - Present

  • 「日本生物工学会」創立100周年記念史

    2022/01/27 - 2022/01/27

Institutional Repository 1

Content Published in the University of Osaka Institutional Repository (OUKA)

  1. Culture Surface Design to Construct Human Tissues for Clinical Application

    キム ミーヘー