JA

Profile

Research

Social

Other

Takeuchi Hiroko

竹内 裕子

Graduate School of Frontier Biosciences Department of Frontier Biosciences, Associate Professor

keyword Ion Channel,Olfactory masking,Olfactory adaptation,Signal transduction,UV,Cyclic nucleotide,Patch Clamp,Chemical Senses,Cilia,AC,Cells,Molecules,Electrophysiology,Sense,Real time recording,LSM,Nano,cAMP,Second messenger,Neruon,Caged substances,Olfactory receptor cell,Olfaction

Research History

  • 2014/04 - Present, Osaka University, Graduate School of Frontier Biosciences
  • 2005/07 - 2005/08, SISSA (International School for Advanced Studies), Neurobiology (Prof. A. Menini), Research fellow
  • 2007/04 - , Osaka University, Graduate School of Frontier Biosciences
  • 2002/04 - , Osaka University, Graduate School of Frontier Biosciences
  • 2000/04 - , Osaka University, Graduate School of Engineering Science

Research Areas

  • Life sciences, Biophysics, Transduction channels, signal amplification, patch clamp
  • Life sciences, Clinical pharmacy, Molecular dynamics
  • Life sciences, Physiology, Physiology, Olfaction, Transduction
  • Life sciences, Neuroscience - general, Cilia, Nano structure, Caged photolysis

Papers

  • Suppression of olfactory signal transduction by insecticides, Takeuchi H,Kurahashi T, npj Science of Food, Vol. 3, No. 9, 2019/06
  • Electrical properties of cells from human olfactory epithelium., Tamari K,Takeuchi H,Kobayashi M,Takeuchi K,Kurahashi T,Yamamoto T, Auris Nasus Larynx., Vol. S0385-8146, No. 18, p. 30697-30697, 2019
  • Second messenger molecules have a limited spread in olfactory cilia., Takeuchi H,Kurahashi T, J Gen Physiol., Vol. 150, No. 12, p. 1647-1659, 2018/12
  • 2,4,6-Trichloroanisole is a potent suppressor of olfactory signal transduction, Hiroko Takeuchi,Hiroyuki Kato,Takashi Kurahashi, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, NATL ACAD SCIENCES, Vol. 110, No. 40, p. 16235-16240, 2013/10
  • Suppression and recovery of voltage-gated currents after cocaine treatments of olfactory receptor cells, Kengo Tamari,Hiroko Takeuchi,Masayoshi Kobayashi,Takashi Kurahashi,Tetsuro Yamamoto, Auris Nasus Larynx, Vol. 40, No. 1, p. 66-70, 2013
  • Recordings from Cultured Newt Olfactory Receptor Cells, Kyohei Matsumura,Masahiro Matsumoto,Takashi Kurahashi,Hiroko Takeuchi, ZOOLOGICAL SCIENCE, ZOOLOGICAL SOC JAPAN, Vol. 29, No. 5, p. 340-345, 2012/05
  • Chemical structures of odorants that suppress ion channels in the olfactory receptor cell, Yukako Kishino,Hiroyuki Kato,Takashi Kurahashi,Hiroko Takeuchi, JOURNAL OF PHYSIOLOGICAL SCIENCES, SPRINGER TOKYO, Vol. 61, No. 3, p. 231-245, 2011/05
  • Mechanism of olfactory masking in the sensory cilia, Hiroko Takeuchi,Hirohiko Ishida,Satoshi Hikichi,Takashi Kurahashi, JOURNAL OF GENERAL PHYSIOLOGY, ROCKEFELLER UNIV PRESS, Vol. 133, No. 6, p. 583-601, 2009/06
  • Distribution, amplification, and summation of cyclic nucleotide sensitivities within single olfactory sensory cilia, Hiroko Takeuchi,Takashi Kurahashi, JOURNAL OF NEUROSCIENCE, SOC NEUROSCIENCE, Vol. 28, No. 3, p. 766-775, 2008/01
  • Odorant inhibition of the olfactory cyclic nucleotide-gated channel with a native molecular assembly, Tsung-Yu Chen,Hiroko Takeuchi,Takashi Kurahashi, JOURNAL OF GENERAL PHYSIOLOGY, ROCKEFELLER UNIV PRESS, Vol. 128, No. 3, p. 365-371, 2006/09
  • Mechanism of signal amplification in the olfactory sensory cilia, H Takeuchi,T Kurahashi, JOURNAL OF NEUROSCIENCE, SOC NEUROSCIENCE, Vol. 25, No. 48, p. 11084-11091, 2005/11
  • Bhc-cNMPs as either water-soluble or membrane-permeant photoreleasable cyclic nucleotides for both one- and two-photon excitation, T Furuta,H Takeuchi,M Isozaki,Y Takahashi,M Kanehara,M Sugimoto,T Watanabe,K Noguchi,TM Dore,T Kurahashi,M Iwamura,RY Tsien, CHEMBIOCHEM, WILEY-V C H VERLAG GMBH, Vol. 5, No. 8, p. 1119-1128, 2004/08
  • Identification of second messenger mediating signal transduction in the olfactory receptor cell, H Takeuchi,T Kurahashi, JOURNAL OF GENERAL PHYSIOLOGY, ROCKEFELLER UNIV PRESS, Vol. 122, No. 5, p. 557-567, 2003/11
  • Cross-adaptation between olfactory responses induced by two subgroups of odorant molecules, H Takeuchi,Y Imanaka,J Hirono,T Kurahashi, JOURNAL OF GENERAL PHYSIOLOGY, ROCKEFELLER UNIV PRESS, Vol. 122, No. 3, p. 255-264, 2003/09
  • Photolysis of caged cyclic AMP in the ciliary cytoplasm of the newt olfactory receptor cell, H Takeuchi,T Kurahashi, JOURNAL OF PHYSIOLOGY-LONDON, CAMBRIDGE UNIV PRESS, Vol. 541, No. 3, p. 825-833, 2002/06
  • Spiking properties of olfactory receptor cells in the slice preparation, Y Imanaka,H Takeuchi, CHEMICAL SENSES, OXFORD UNIV PRESS, Vol. 26, No. 8, p. 1023-1027, 2001/10
  • Physiology of morphologically identified cells of the bullfrog fungiform papilla, H Takeuchi,T Tsunenari,T Kurahashi,A Kaneko, NEUROREPORT, LIPPINCOTT WILLIAMS & WILKINS, Vol. 12, No. 13, p. 2957-2962, 2001/09

Misc.

  • Mechanism of signal amplification in the newt olfactory sensory cilia, H. Takeuchi,T. Kurahashi, CHEMICAL SENSES, OXFORD UNIV PRESS, Vol. 31, No. 5, p. A10-A10, 2006/06
  • 香りを感じる仕組みはエネルギー節約型 : ナノスケール神経プロセス内分子の実時間測定, 竹内 裕子, 日本生理学雜誌 = JOURNAL OF THE PHYSIOLOGICAL SOCIETY OF JAPAN, Vol. 68, No. 5, 2006/05/01
  • 嗅覚情報伝達におけるセカンドメッセンジャーはcAMPである, 竹内 裕子, 生物物理, 日本生物物理学会, Vol. 44, No. 4, p. 176-179, 2004/07/25
  • ユーカリ・エッセンシャルオイルはどのように嗅覚受容細胞を興奮させるか, 竹内 裕子,守屋 奈緒,倉橋 隆, Aroma research, フレグランスジャーナル社, Vol. 4, No. 4, p. 336-343, 2003
  • 2P178Caged化合物を用いた細胞内因子の自由制御 : サブミクロンの嗅繊毛膜内cGMPをターゲットにして, 竹内 裕子,倉橋 隆, 生物物理, 日本生物物理学会, Vol. 41, No. 1, 2001/09/10
  • 2P179嗅粘膜スライス標本内における嗅細胞の活動電位特性, 今中 幸江,竹内 裕子,倉橋 隆, 生物物理, 日本生物物理学会, Vol. 41, No. 1, 2001/09/10
  • 1SMN1-4 味覚センサー細胞の味蕾内配置と応答性及び情報変換機構, 竹内 裕子,恒成 隆,金子 章道,倉橋 隆, 生物物理, 日本生物物理学会, Vol. 40, No. 1, 2000/08/05

Publications

  • Molecular Mechanism of Olfactory Masking by 2, 4, 6-Trichloroanisole, Hiroko TAKEUCHI, 日本醸造協会誌第114巻3号, 2019/03
  • Topics in Medical Chemistry, Taste and Smell, Takeuchi H,Kurahashi T, Springer, 2017
  • 嗅細胞における信号増幅とマスキング, 倉橋隆,竹内裕子, Clinical Neuroscience Vol.34 (16年) 12月号 嗅覚—New horizon 中外医学社, 2016/12
  • 嗅覚, 竹内裕子,倉橋隆, Clinical Neuroscience Vol.33, p.516 (15年) 05月号 感覚とその異常 中外医学社, 2015/05
  • 2,4,6-trichroloanisoleによる嗅覚経路の抑制, 倉橋 隆,竹内裕子, AROMA RESEARCH, No.56 vol.14/No.4, カレントトピックス, 2013/11
  • おもしろサイエンス神経細胞の科学, 倉橋隆,竹内裕子, 日刊工業新聞社, 2013/04
  • The Senses: A Comprehensive References, Six-Volume Set, 1-6, Takeuchi H,Kurahashi T, Elsevier, 2008
  • 匂いと香りの科学, 竹内裕子,倉橋, 朝倉書店, 2007
  • Quantitative Analysis of Signal Transduction in the Olfactory Receptor Cell, Hiroko Takeuchi,Takashi Kurahashi, Springer, Tokyo, 2003
  • 嗅細胞のセカンドメッセンジャーとイオンチャネル, 渡辺京子,竹内裕子,倉橋隆, フレグランスジャーナル社, 2002
  • 匂いレセプターシリーズ・バイオサイエンスの新世紀 第12巻「感覚器官と脳内情報処理」, 竹内裕子,倉橋隆, 共立出版, 2001

Awards

  • 大阪大学総長奨励賞(研究部門), 竹内裕子, 2015/07
  • The Young Scientists’ Prize, Hiroko Takeuchi, Ministry of Education, Culture, Sports, Science and Technology (MEXT), 2015/04
  • 大阪大学総長奨励賞(研究部門), 竹内裕子, 2014/07
  • Young Investigator Award, Hiroko Takeuchi, THE FEDERATION OF THE ASIAN AND OCEANIAN PHYSIOLOGICAL SOCIETIES, 2011/09
  • Promotion Award of the Physiological Society of Japan for Young Scientists, The Physiological Society of Japan, 2006/05

Presentations

  • 嗅細胞における嗅覚マスキングの分子機構, 竹内裕子,倉橋隆, 第67回 中部日本生理学会, 2020/10/16
  • 嗅シリアサブミクロン区画における [Ca]i と膜電流の同時計測, 竹内裕子,倉橋隆, 生理研研究会「イオンチャネルと生体膜のダイナミズム:構造生物学の先にあるもの」, 2020/10/06
  • 嗅細胞での内向き単一チャネルの検討, 倉橋隆,竹内裕子, 第112回 近畿生理談話会, 2019/11/06
  • イモリ嗅細胞のベーサル活動に関する検討, 竹内裕子,倉橋隆, 第112回 近畿生理談話会, 2019/11/06
  • おいしさの科学 ~匂いがあるのに匂わない?普段は気づきにくい嗅覚の重要性~, 竹内裕子, 第51回大阪大学公開講座2019, 2019/10/21
  • 線毛内情報伝達分子の実時間可視化, 竹内裕子,倉橋隆, 2019年度 生理研研究会
  • 嗅覚マスキングとイオンチャネルの抑制, 竹内裕子, 第40回動物細胞工学シンポジウム, 2019/03/08
  • 視細胞ターミナルや嗅線毛に存在するCa2+感受性Clチャネルの記録, 倉橋隆,竹内裕子, 第111回 近畿生理談話会, 2018/11/17
  • 食品の臭み消しに関して嗅細胞レベルでの検討, 竹内裕子,倉橋隆, 第111回 近畿生理談話会, 2018/11/17
  • Electrical properties of cells from human olfactory epithelium., Kengo Tamari,Hiroko Takeuchi,Masayoshi Kobayashi,Kazuhiko Takeuchi,Takashi Kurahashi,Tetsuro Yamamoto, 95rd Annual meeting of the Physiological Society of Japan., 2018
  • ワインのブショネの生体機能解明, 竹内裕子, 洋酒技術研究会, 2018
  • Electrostatic control of current rectification by the sidechain Charge of K584 in TMEM16A calcium-activated chloride channel., Tsung-Yu Chen,Louisa S Chen,Grace Jeng,Dung Nguyen,Wei-Ping Yu,Hiroko Takeuchi,Takashi Kurahashi, 94rd Annual meeting of the Physiological Society of Japan., 2017
  • Ion channels mediating sense of smell., Takeuchi H,Kurahashi T, Seminar, Neurobiology of Ion Channels Department of Neurosciences, University of Groningen, The Netherlands., 2017
  • Modulation by off-flavors of CNG channels in olfactory cilia., Takeuchi H,Kurahashi T, The 60th Biophysical Society Annual Meeting. Los Angeles, CA, USA., 2016
  • Independent activation of the two subunits of the TMEM16 calcium-activated chloride channel., Grace Jeng,Takeuchi H,Kurahashi T,Tsung-Yu Chen, 93rd Annual meeting of the Physiological Society of Japan., 2016
  • Haloanisoles suppress activation of the cyclic nucleotidegated channel in the olfactory cilia., Hiroko Takeuchi, AChemS XXXVIII 38th Annual Meeting, FL, USA., 2016
  • Mechanisms of Flavor Loss in Foods and Beverages., Takeuchi H,Kurahashi T, Physiology 2016. Joint meeting of the American Physiological Society and The Physiological Society. Convention Center. Dublin, Ireland., 2016
  • Molecular mechanism of the olfactory masking., Hiroko Takeuchi, Brain’s spark: Biophysics of neurotransmitter receptors and channels. The 39th Annual Meeting of the Japan Neuroscience Society., 2016
  • Modulation of CNG channel activity in olfactory cilia., Takeuchi H,Kurahashi T, International Conference of Physiological Sciences 2016. Beiging, China., 2016
  • Modulation of CNG channels activity in the olfactory cilia., Takeuchi H,Kurahashi T, Physiology 2015, Physiological Society. Cardiff, UK., 2015
  • Diffusion limitation of second messenger molecules in the olfactory cilium., Takeuchi H, International Symposium for Signal Transduction of Sensory Neurons., 2015
  • TCA suppresses the olfactory transduction channel., Takeuchi H,Kurahashi T, 91st Annual meeting of the Physiological Society of Japan., 2014
  • High efficiency suppression of olfactory CNG channels may explain the olfactory masking and degradation of foods and beverages., Hiroko Takeuchi, “Cutting-edge approaches towards the functioning mechanisms of membrane proteins”. National Institute for Physiological Science., 2014
  • Diffusion limitation of second messengers in the single olfactory cilium., Takeuchi H,Kurahashi T, 90th Annual meeting of the Physiological Society of Japan., 2013
  • Off-Flavors in Foods and Beverages Cause a Potent Blockage of the Olfactory Signal Transduction., Takeuchi H,Kurahashi T, AchemS XXXIV 34th Annual Meeting, CA, USA, 2012
  • Diffusion limitation of second messengers in the single olfactory cilium., Takeuchi H,Kurahashi T, 89th Annual meeting of the Physiological Society of Japan., 2012
  • Odorant suppression of channel activity in the isolated olfactory cells., Tanigaki H,Takeuchi H, JASTS (Annual meeting), 2012
  • Analysis of the single potassium channel in the isolated newt olfactory receptor cells., Aoki M,Takeuchi H, JASTS (Annual meeting), 2012
  • Primary culture and recordings from the newt olfactory receptor cells., Matsumura K,Yamato S,Takeuchi H, JASTS (Annual meeting), 2012
  • Categories of voltage-dependent potassium channels in the newt olfactory receptor cells, Sakata N,Takeuchi H, JASTS (Annual meeting)., 2012
  • Workshop on Molecular Biology for studies on consciousness., Takeuchi H,Kurahashi T, International Institute for Advances Studies, 2011
  • Modulation of transduction channels by odorants in the olfactory cilia., Takeuchi H,Kurahashi T, 87th Annual meeting of the Physiological Society of Japan., 2010
  • Suppression by odorants of voltage-gated ion channels of newt olfactory receptor cells., Yoshida T,Takeuchi H,Kurahashi T, The 36th Congress of the IUPS, 2009
  • Visualization and quantitative analysis of the nano-scale olfactory sensory cilia., Kishino Y,Takeuchi H,Kurahashi T, The 36th Congress of the IUPS., 2009
  • Mechanism of olfactory masking in the sensory cilia., Takeuchi H,Ishida H,Hikichi S,Kurahashi T, The 36th Congress of the IUPS, 2009
  • MS-Windows application executing the non-stationary noise analysis of whole-cell transient current., Sugahara A,Oi H,Kurahashi T,Takeuchi H, 85th Annual meeting of the Physiological Society of Japan., 2008
  • Photolysis of Caged Calcium in the Olfactory Sensory Cilia., Takeuchi H,Kurahashi T, 85th Annual meeting of the Physiological Society of Japan., 2008
  • Mechanism of Olfactory Masking., Kurahashi T,Takeuchi H,Ishida H,Hikichi S, International Symposium on Olfaction and Taste, ISOT, CA, USA, 2008
  • CNG block may reduce the olfactory sensitivity., Kurahashi T,Takeuchi H,Ishida H,Hikichi S, ECRO 2008, Portoroz, Slovenia, 2008
  • Visualization. manipulation, recording of nanotube olfactory cilia., Takeuchi H,Kurahashi T, ECRO 2008, Portoroz, Slovenia, 2008
  • Real-time molecular dynamics in the olfaction: The study of combined with an optical technology, an electrophysiology and nano-biology., Takeuchi H, Lecture, Shiseido, 2008
  • Spatial Distribution of the Signal Transduction System in the Single Olfactory Cilia., Takeuchi H,Kurahashi T, 85th Annual meeting of the Physiological Society of Japan., 2008
  • Physiology of olfaction, Hiroko Takeuchi, Lecture, Kao Corporation., 2008
  • Distribution, amplification, and summation of cyclic nucleotide sensitivities within single olfactory sensory cilia., Takeuchi H,Kurahashi T, Seminar of Institut für Pharmakologie und Toxikologie, University of Wuerzburg, Germany., 2008
  • CNG Block by Odorants May be the Molecular Mechanism Mediating Olfactory Masking., Takeuchi H, Kao Brands Company Meeting, Cincinnati, USA., 2008
  • Spatial Distribution of Transduction System with Nano-scale Resolution in Living Olfactory Cilia., Takeuchi H,Kurahashi T, AchemS XXIX 29th Annual Meeting, FL, USA., 2007
  • Sub-micron UV-laser regulation of cytoplasmic factor in living sensory cilia., Takeuchi H,Kurahashi T, 84th Annual meeting of the Physiological Society of Japan., 2007
  • Mechanism of signal amplification in the newt olfactory sensory cilia., Takeuchi H,Kurahashi T, AchemS 28th Annual Meeting, FL, USA., 2006
  • Mechanism of signal amplification in the olfactory sensory cilia., Takeuchi H,Kurahashi T, 83rd Annual meeting of the Physiological Society of Japan., 2006
  • Real-time dynamics of molecular elements within the nano-scale olfactory sensory cilia., Takeuchi H,Kurahashi T, International Symposium of Olfaction and Taste., 2006
  • Cyclic-AMP dynamics and adenylyl cyclase activities within the olfactory cilia., Takeuchi H,Kurahashi T, AchemS XXVII 27th Annual Meeting, FL, USA., 2005
  • cAMP concentration and adenylyl cyclase activities in the olfactory cilia, Takeuchi H,Kurahashi T, 82nd Annual meeting of the Physiological Society of Japan., 2005
  • Identification of the second messenger that mediates signal transduction in the newt olfactory receptor cell., Takeuchi H,Kurahashi T, AchemS XXVI 26th Annual Meeting, FL, USA., 2004
  • Real time estimation of cAMP change during the photolysis responses in the olfactory cilia., Takeuchi H,Kurahashi T, 81st Annual meeting of the Physiological Society of Japan., 2004
  • Involvement of cAMP for ‘IP3 odorant’ transduction in single olfactory cells., Takeuchi H,Kurahashi T, Seminar, Japan Women’s University, 2004
  • cAMP as a universal second messenger mediating signal transduction in the newt olfactory receptor cell., Takeuchi H,Kurahashi T, International Symposium on Chemical Senses and Insect Behavior., 2004
  • Responses induced by IP3-producing odorants in the olfactory receptor cells., Takeuchi H,Kurahashi T, 80th Annual meeting of the Physiological Society of Japan., 2003
  • cAMP As a Universal Soluble Factor Mediating Olfactory Signal Transduction., Takeuchi H,Kurahashi T, Seminar, University of Tokyo, 2003
  • Odorant Inhibition of Cloned Olfactory Cyclic Nucleotide-Gated Channels., Chen TY,Takeuchi H,Kurahashi T, IUPS symposium; Olfactory transduction, 2003
  • Control of cAMP in the ciliary cytoplasm of the olfactory receptor cell., Takeuchi H,Kurahashi T, HFSP symposium, Colorado, USA., 2002
  • Physiological properties of three types of cells in the Bullfrog taste bud morphological identified by intracellular staining., Takeuchi H,Tsunenari T,Kaneko A, 77th Annual meeting of the Physiological Society of Japan., 2001
  • Electrophysiological properties of cells in the frog slice preparations., Takeuchi H,Imanaka Y,Kurahashi T, 78th Annual meeting of the Physiological Society of Japan., 2001
  • Electrophysiological properties of taste papillae of the bullfrog morphologically identified by intracellular staining., Takeuchi H,Tsunenari T,Kaneko A, JASTS (Annual meeting), 1999

Media Coverage

  • 嗅覚乱され ワイン「まずい」, 2013/09
  • 嗅覚乱しワインまずくする物資 阪大などのチーム解明, 共同通信社, 2013/09
  • ワインの風味落とす物質=微量で嗅覚遮断-大阪大など, 時事通信社, 2013/09
  • ¿Por que algunos vinos huelen a corcho?, ABC.es, 2013/09
  • Corked Wine Ruins Pleasant Aroma of Drink, Top News Arab Emirates, 2013/09
  • ワインの風味落とす物質=微量で嗅覚遮断―大阪大など, 2013/09
  • 科学家找出木塞污染影响葡萄酒香气的真正原因, 中国新聞網, 2013/09
  • ワインのコルク臭 意外な仕組み, 2013/09
  • ”コルク汚染”原因物質 嗅覚遮断引き起こす, 2013/09
  • 劣化物質放出、嗅覚に乱れ, 2013/09
  • Corked wine confuses smell receptors, ABC, 2013/09
  • Secret to Bad-Smelling Wine Revealed, Live Science, 2013/09
  • News in Brief: Chemical behind corked wine quashes other aromas., Science News, 2013/09
  • Corked Wine Plugs Up Your Nose., 2013/09
  • Musty flavour of corked wine is caused by a chemical that KNOCKS OUT your sense of smell, The Daily Mail, 2013/09
  • Korkiger Wein verändert den Geruchssinn, 2013/09
  • Newts reveal why corked wine smells of mouldy socks, The Times, 2013/09
  • Your bottle of fine corked wine have bouquet of a wet dog? Here's why, 2013/09
  • Corked wine can 'shut down' the nose, 2013/09

Social Activities

  • Science talk, Science world, Science zone, 立命館中学校・高等学校, Japan Super Science Fair, 2014 - Present
  • 臭気判定技術講習会 講師(生理学担当), 公益社団法人 におい・かおり環境協会, 臭気判定技術講習会(2016年度は除く), 2014 - Present