Novel Anti-Human Immunodeficiency Virus Compounds with Activity against Cyclophilin A: A Look Back

Yu-Shi Tian, Norihito Kawashita, Masanori Kameoka, Tatsuya Takagi

Journal of Prevention & Infection Control　Vol. 2　No. 2:12　p. 1-5　2016/11

Quantitative Structure-Activity Relationship Model for the Fetal-Maternal Blood Concentration Ratio of Chemicals in Humans

Tomoyuki Takaku, Hirohisa Nagahori, Yoshihisa Sogame, Tatsuya Takagi

BIOLOGICAL & PHARMACEUTICAL BULLETIN　Vol. 38　No. 6　p. 930-934　2015/06　Research paper (scientific journal)

Meta-analysis of the risk of upper gastrointestinal hemorrhage with combination therapy of selective serotonin reuptake inhibitors and non-steroidal anti-inflammatory drugs

Yoshinari Oka, Kousuke Okamoto, Norihito Kawashita, Yuko Shirakuni, Tatsuya Takagi

Biological and Pharmaceutical Bulletin　Vol. 37　No. 6　p. 947-953　2014　Research paper (scientific journal)

Statistical Evaluation of Single-Photon Emission Computed Tomography Image Using Smoothed Bootstrap Method

Megumi Tsukamoto, Asuka Hatabu, Yoshitake Takahashi, Hiroshi Matsuda, Kousuke Okamoto, Noriyuki Yamashita, Tatsuya Takagi

Biological and Pharmaceutical Bulletin　Vol. 36　No. 3　p. 417-424　2013/03　Research paper (scientific journal)

Discovery of novel low-molecular-weight HIV-1 inhibitors interacting with cyclophilin A using in silico screening and biological evaluations

Yu-Shi Tian, Chris Verathamjamras, Norihito Kawashita, Kousuke Okamoto, Teruo Yasunaga, Kazuyoshi Ikuta, Masanori Kameoka, Tatsuya Takagi

JOURNAL OF MOLECULAR MODELING　Vol. 19　No. 1　p. 465-475　2013/01　Research paper (scientific journal)

Development of Novel Evaluation Method to Anti-influenza Drug Resistance using Docking Study

Kawashita N, Yasuda M, Tian Y.-S, Okamoto K, Kawase M, Yasunaga T, Takagi T

Antiviral Research　Vol. 90　No. 2　2011/05

Nonlinear classification of hERG channel inhibitory activity by unsupervised classification method

Shinnosuke Hidaka, Hiroyuki Yamasaki, Yoshihiro Ohmayu, Akiko Matsuura, Kousuke Okamoto, Norihito Kawashita, Tatsuya Takagi

The Journal of Toxicological Sciences　Vol. 35　No. 3　p. 393-399　2010　Research paper (scientific journal)

Safety comparisons among monoamine oxidase inhibitors against Parkinson’s disease using FDA adverse event reporting system

Hiroto Asano, Yu-Shi Tian, Asuka Hatabu, Tatsuya Takagi, Mikiko Ueda, Kenji Ikeda

Scientific Reports　Vol. 13　No. 1　p. 1-10　2023/11/06　Research paper (scientific journal)

DTAmetasa: an R shiny application for meta-analysis of diagnostic test accuracy and sensitivity analysis of publication bias

Shosuke Mizutani, Yi Zhou, Yu-Shi Tian, Tatsuya Takagi, Tadayasu Ohkubo, Satoshi Hattori

Research Synthesis Methods　Vol. 2023　p. 1-11　2023/09　Research paper (scientific journal)

Genetic algorithm-based feature selection with manifold learning for cancer classification using microarray data

Zixuan Wang, Yi Zhou, Tatsuya Takagi, Jiangning Song, Yu-Shi Tian, Tetsuo Shibuya

BMC Bioinformatics　Vol. 24　No. 1　p. 1-22　2023/04/08　Research paper (scientific journal)

How Beneficial or Threatening is Artificial Intelligence?

Tatsuya TAKAGI

Chem-Bio Informatics Journal　Vol. 23　p. 7-13　2023/02/20　Research paper (scientific journal)

The efficacy of Golimumab against non-infectious uveitis: a PRISMA-compliant systematic review and meta-analysis

Katsuya Okada, Yi Zhou, Noriyasu Hashida, Tatsuya Takagi, Yu-Shi Tian

Ocular Immunology and Inflammation　Vol. 30　p. 1-11　2022/10　Research paper (scientific journal)

Safety, efficacy, and cost-effectiveness of insulin degludec U100 versus insulin glargine U300 in adults with type 1 diabetes: A systematic review and indirect treatment comparison

Martin, Zhou Yi, Tatsuya Takagi, Yu-Shi Tian

International Journal of Clinical Pharmacy　2022　Research paper (scientific journal)

Predicting the side effects of drugs using matrix factorization on spontaneous reporting database.

Kohei Fukuto, Tatsuya Takagi, Yu-Shi Tian

Scientific reports　Vol. 11　No. 1　p. 23942-23942　2021/12/14　Research paper (scientific journal)

Correction to: Efficacy and safety among second-generation and other basal insulins in adult patients with type 1 diabetes: a systematic review and network meta-analysis (Naunyn-Schmiedeberg's Archives of Pharmacology, (2021), 394, 10, (2091-2101), 10.1007/s00210-021-02128-9)

Martin, Yi Zhou, Tatsuya Takagi, Yu-Shi Tian

Naunyn-Schmiedeberg's Archives of Pharmacology　Vol. 394　No. 10　2021/10/01　Research paper (scientific journal)

Tapentadol in Cancer Patients with Neuropathic Pain: A Comparison of Methadone, Oxycodone, Fentanyl, and Hydromorphone

Miho Takemura, Kazuyuki Niki, Yoshiaki Okamoto, Yoshinobu Matsuda, Takahito Omae, Tatsuya Takagi, Mikiko Ueda

Biological and Pharmaceutical Bulletin　Vol. 44　No. 9　p. 1286-1293　2021/09/01　Research paper (scientific journal)

Efficacy and safety among second-generation and other basal insulins in adult patients with type 1 diabetes: a systematic review and network meta-analysis

Martin, Yi Zhou, Tatsuya Takagi, Yu-Shi Tian

Naunyn-Schmiedeberg's Archives of Pharmacology　Vol. 394　No. 10　p. 2091-2101　2021/07/28　Research paper (scientific journal)

Computational Ab Initio Interaction Analyses between Neutralizing Antibody and SARS-CoV-2 Variant Spike Proteins Using the Fragment Molecular Orbital Method

Kazuki Watanabe, Chiduru Watanabe, Teruki Honma, Yu-Shi Tian, Yusuke Kawashima, Norihito Kawashita, Kaori Fukuzawa, Tatsuya Takagi

Bulletin of the Chemical Society of Japan　Vol. 94　No. 6　p. 1794-1798　2021/06/15　Research paper (scientific journal)

Double mutations in the H9N2 avian influenza virus PB2 gene act cooperatively to increase viral host adaptation and replication for human infections

Emad Mohamed Elgendy, Yasuha Arai, Norihito Kawashita, Ayana Isobe, Tomo Daidoji, Madiha Salah Ibrahim, Takao Ono, Tatsuya Takagi, Takaaki Nakaya, Kazuhiko Matsumoto, Yohei Watanabe

Journal of General Virology　Vol. 102　No. 6　2021/06/01　Research paper (scientific journal)

Intermolecular Interaction Analyses on SARS-CoV-2 Spike Protein Receptor Binding Domain and Human Angiotensin-Converting Enzyme 2 Receptor-Blocking Antibody/Peptide Using Fragment Molecular Orbital Calculation

Kazuki Watanabe, Chiduru Watanabe, Teruki Honma, Yu-Shi Tian, Yusuke Kawashima, Norihito Kawashita, Tatsuya Takagi, Kaori Fukuzawa

The Journal of Physical Chemistry Letters　Vol. 12　No. 16　p. 4059-4066　2021/04/29　Research paper (scientific journal)

Integrating Behavioral Economics in Pharmacy Education:Surveying Students' Knowledge and Interest

Hatabu Asuka, Uejima Etsuko, Takagi Tatsuya, Ueda Mikiko

Igaku Kyoiku / Medical Education (Japan)　Vol. 52　No. 2　p. 91-96　2021/04/25

トピックモデルによりサリドマイド製剤安全管理手順(TERMS)のアンケートから得られた患者の関心事の解析

岡本 晃典, 田 雨時, 高木 達也

日本薬学会年会要旨集　Vol. 141年会　p. 27P01-247　2021/03

FMODB: The World’s First Database of Quantum Mechanical Calculations for Biomacromolecules Based on the Fragment Molecular Orbital Method

Daisuke Takaya, Chiduru Watanabe, Shunpei Nagase, Kikuko Kamisaka, Yoshio Okiyama, Hirotomo Moriwaki, Hitomi Yuki, Tomohiro Sato, Noriyuki Kurita, Yoichiro Yagi, Tatsuya Takagi, Norihito Kawashita, Kenichiro Takaba, Tomonaga Ozawa, Midori Takimoto-Kamimura, Shigenori Tanaka, Kaori Fukuzawa, Teruki Honma

Journal of Chemical Information and Modeling　Vol. 61　No. 2　p. 777-794　2021/02/22　Research paper (scientific journal)

Intermolecular Interaction Analyses on SARS-CoV-2 Receptor Binding Domain and Human Angiotensin-Converting Enzyme 2 Receptor-Blocking Antibody/peptide Using Fragment Molecular Orbital Calculation

Kazuki Watanabe, Chiduru Watanabe, Teruki Honma, Yu-Shi Tian, Yusuke Kawashima, Norihito Kawashita, Tatsuya Takagi, Kaori Fukuzawa

ChemRxiv　Vol. 38　No. 1　p. 1-88　2021/02　Research paper (scientific journal)

Knowledge, attitudes, and practices toward COVID-19 among university students in Japan and associated factors: An online cross-sectional survey

Asuka Hatabu, Xinhua Mao, Yi Zhou, Norihito Kawashita, Zheng Wen, Mikiko Ueda, Tatsuya Takagi, Yu-Shi Tian

PLOS ONE　Vol. 15　No. 12　p. e0244350-e0244350　2020/12/21　Research paper (scientific journal)

PA Mutations Inherited during Viral Evolution Act Cooperatively To Increase Replication of Contemporary H5N1 Influenza Virus with an Expanded Host Range

Yasuha Arai, Norihito Kawashita, Emad Mohamed Elgendy, Madiha Salah Ibrahim, Tomo Daidoji, Takao Ono, Tatsuya Takagi, Takaaki Nakaya, Kazuhiko Matsumoto, Yohei Watanabe

Journal of Virology　Vol. 95　No. 1　p. e01582-20-e01582-20　2020/10/07　Research paper (scientific journal)

がん患者の神経障害性疼痛に対するオピオイドの比較検討

竹村 美穂, 仁木 一順, 岡本 禎晃, 松田 良信, 大前 隆仁, 高木 達也, 上田 幹子

Palliative Care Research　Vol. 15　No. Suppl.　p. S316-S316　2020/08

A Comparison between the Cycloadditions of Allenyl- and Vinyl-Cyclopentanes Using Density Functional Theory and GRRM Program

Kazuki Watanabe, Yusuke Kawashima, Chisato Mukai, Tatsuya Takagi, Yukinori Suwa, Yu-Shi Tian, Norihito Kawashita

Chemical and Pharmaceutical Bulletin　Vol. 68　No. 8　p. 737-741　2020/08/01　Research paper (scientific journal)

Evidence of Passive Smoking as a Risk Factor of High-Grade Squamous Intraepithelial Lesion: A Case-Control Study

Xinxin Du, Mingxia Li, Yi Zhou, Hao Yang, Vladimir Isachenko, Tatsuya Takagi, Yuanguang Meng

Biological and Pharmaceutical Bulletin　Vol. 43　No. 7　p. 1061-1066　2020/07/01　Research paper (scientific journal)

がん患者の神経障害性疼痛に対するタペンタドールの有効性に関する検討 タペンタドールとメサドン、フェンタニル、オキシコドンの比較研究

竹村 美穂, 仁木 一順, 岡本 禎晃, 松田 良信, 大前 隆仁, 高木 達也, 上田 幹子

日本薬学会年会要旨集　Vol. 140年会　p. 26L-am09S　2020/03

Absorption, Fluorescence, and Two-Photon Excitation Ability of 5-Phenylisolidolo[2,1-a]quinolines

Ramon Francisco Avena, Lin Qiao, Yuki Fujii, Kohei Otomo, Hirokazu Ishii, Takeyuki Suzuki, Hirofumi Tsujino, Tadayuki Uno, Yasuo Tsutsumi, Yusuke Kawashima, Tatsuya Takagi, Kenichi Murai, Tomomi Nemoto, Mitsuhiro Arisawa

ACS Omega　Vol. 5　No. 5　p. 2473-2479　2020/01/17　Research paper (scientific journal)

Survey of University Students' Self-medication Interest and Energy Drink Use Trend: A Pilot Study

Hatabu Asuka, Toda Shyohei, Tanide Sayaka, Uejima Etsuko, Takagi Tatsuya, Ueda Mikiko

Japanese Journal of Social Pharmacy　Vol. 39　No. 1　p. 2-11　2020　Research paper (scientific journal)

Inhibiting guanine oxidation and enhancing excess-electron-transfer efficiency of a pyrene-modified oligonucleotide by introducing an electron-donating group on pyrene

Takumi Okuda, Yusuke Kawashima, Yuuya Kasahara, Tatsuya Takagi, Junpei Yamamoto, Shigenori Iwai, Satoshi Obika

Chemical Communication　Vol. 2019　No. 5　p. 14062-14065　2019/10/23　Research paper (scientific journal)

Meta-analysis of BCG effect on prevention of tuberculosis in children

Yoshinari Oka, Yu-shi Tian, Asuka Hatabu, Tatsuya Takagi

The Japanese Journal of Developmental Pharmacology and Therapeutics　Vol. 32　No. 1　p. 65-81　2019/10　Research paper (scientific journal)

テキストマイニングによるサリドマイド製剤安全管理手順(TERMS)における患者対象調査の解析

川瀬 裕貴, 田 雨時, 白國 優子, 一條 知昭, 高木 達也

社会薬学　Vol. 38　No. Suppl.　p. 118-118　2019/09　Research paper (scientific journal)

大学生のセルフメディケーションに対する関心及びエナジードリンクの使用状況に関するアンケート調査研究

幡生 あすか, 戸田 祥平, 谷手 紗也香, 上島 悦子, 高木 達也, 上田 幹子

社会薬学　Vol. 38　No. Suppl.　p. 104-104　2019/09

PB2 mutations arising during H9N2 influenza evolution in the Middle East confer enhanced replication and growth in mammals

Yasuha Arai, Norihito Kawashita, Madiha Salah, Ibrahim Emad, Mohamed Elgendy Tomo Daidoji, Takao Ono, Tatsuya Takagi, Takaaki Nakaya, Kazuhiko Matsumoto, Yohei Watanabe

PLOS Pathogens　Vol. 15　No. 7　2019/07/02　Research paper (scientific journal)

Virtual Realityを用いた思い出の場所への疑似外出は終末期がん患者の症状を改善する新たな手法になりうるか?

仁木 一順, 岡本 禎晃, 前田 一石, 森 一郎, 松田 良信, 石井 良平, 上田 幹子, 高木 達也, 上島 悦子

Palliative Care Research　Vol. 14　No. Suppl.　p. S229-S229　2019/06　Research paper (scientific journal)

11β-hydroxysteroid dehydrogenase type 1 is associated with antiretroviral therapy-induced increase in low-density lipoprotein cholesterol

Kazuyuki Niki, Kazuo Harada, Shinich Hikasa, Mamiko Tsugane, Mikiko Ueda, Satoshi Higasa, Takeshi Kimura, Tatsuya Takagi, Etsuko Uejima

Int. Journal of Clinical Pharmacology and Therapeutics　Vol. 57　No. 06　p. 298-305　2019/06/01　Research paper (scientific journal)

A Novel Palliative Care Approach Using Virtual Reality for Improving Various Symptoms of Terminal Cancer Patients: A Preliminary Prospective, Multicenter Study.

Kazuyuki Niki, Yoshiaki Okamoto, Isseki Maeda, Ichiro Mori, Ryouhei Ishii, Yoshinobu Matsuda, Tatsuya Takagi, Etsuko Uejima

Journal of Palliative Medicine　Vol. 22　No. 6　p. 702-707　2019/06　Research paper (scientific journal)

Metal-Free Nitrogen-Containing Polyheterocyclic Near-Infrared (NIR) Absorption Dyes: Synthesis, Absorption Properties, and Theoretical Calculation of Substituted 5-Methylisoindolo[2,1- a]quinolines

Yuki Fujii, Yukinori Suwa, Yuki Wada, Tsunayoshi Takehara, Takeyuki Suzuki, Yusuke Kawashima, Norihito Kawashita, Tatsuya Takagi, Hiromichi Fujioka, Mitsuhiro Arisawa

ACS Omega　Vol. 4　No. 3　p. 5064-5075　2019/03/08　Research paper (scientific journal)

革新的医療機器開発の最前線 新しいEnd-of-lifeケアの創出を目指したVirtual realityの医療応用

仁木 一順, 岡本 禎晃, 前田 一石, 森 一郎, 石井 良平, 松田 良信, 高木 達也, 上島 悦子

日本薬学会年会要旨集　Vol. 139年会　No. 1　p. 226-226　2019/03

ロジウム触媒による環化付加反応の計算化学的検討

諏訪 志典, 渡邉 一樹, 川嶋 裕介, 田 雨時, 川下 理日人, 高木 達也

日本薬学会年会要旨集　Vol. 139年会　No. 2　p. 258-258　2019/03　Research paper (conference, symposium, etc.)

肺がんの遺伝子に基づく病原遺伝子判別モデルの構築

婁 殿宇, 川下 理日人, 高木 達也, 田 雨時

日本薬学会年会要旨集　Vol. 139年会　No. 2　p. 259-259　2019/03

Vonoprazan versus proton pump inhibitors in treating post-endoscopic submucosal dissection ulcers and preventing bleeding: Protocol for meta-analysis of randomized controlled trials and observational studies.

Martin, Yi Zhou, Chun-Xu Meng, Tatsuya Takagi, Yu-Shi Tian

Medicine　Vol. 98　No. 8　2019/02　Research paper (scientific journal)

Validation of a Short-Term, Objective, Prognostic Predictive Method for Terminal Cancer Patients in a Palliative Care Unit Using a Combination of Six Laboratory Test Items.

Kazuyuki Niki, Yoshiaki Okamoto, Yuka Matano, Ryohei Ishii, Yoshinobu Matsuda, Tatsuya Takagi, Etsuko Uejima

Journal of Palliative Medicine　Vol. 22　No. 6　p. 685-690　2019/01/14　Research paper (scientific journal)

Inhibiting guanine oxidation and enhancing the excess-electron-transfer efficiency of a pyrene-modified oligonucleotide by introducing an electron-donating group on pyrene

Takumi Okuda, Yusuke Kawashima, Yuuya Kasahara, Tatsuya Takagi, Junpei Yamamoto, Shigenori Iwai, Satoshi Obika

Chemical Communications　Vol. 55　No. 93　p. 14062-14065　2019　Research paper (scientific journal)

Multiple polymerase gene mutations for human adaptation occurring in Asian H5N1 influenza virus clinical isolates

Yasuha Arai, Norihito Kawashita, Kozue Hotta, Phuong Vu Mai Hoang, Hang Le Khanh Nguyen, Thach Co Nguyen, Cuong Duc Vuong, Thanh Thi Le, Mai Thi Quynh Le, Kosuke Soda, Madiha S. Ibrahim, Tomo Daidoji, Tatsuya Takagi, Tatsuo Shioda, Takaaki Nakaya, Toshihiro Ito, Futoshi Hasebe, Yohei Watanabe

Scientific Reports　Vol. 8　No. 1　p. 13066-13066　2018/12　Research paper (scientific journal)

サリドマイド製剤安全管理手順(TERMS)逸脱事例の解析

松下 緋菜, 白國 優子, 一條 知昭, 田 雨時, 高木 達也

社会薬学　Vol. 37　No. Suppl.　p. 106-106　2018/09

Characterization of H5N1 influenza virus quasispecies with adaptive hemagglutinin mutations from single-virus infections of human airway cells

Yohei Watanabe, Yasuha Arai, Norihito Kawashita, Madiha S. Ibrahim, Emad M. Elgendy, Tomo Daidoji, Junichi Kajikawa, Hiroaki Hiramatsu, Nongluk Sriwilaijaroen, Takao Ono, Tatsuya Takagi, Kazuo Takahashi, Tatsuo Shioda, Kazuhiko Matsumoto, Yasuo Suzuki, Takaaki Nakaya

Journal of Virology　Vol. 92　No. 11　p. 1-19　2018/06/01　Research paper (scientific journal)

セレギリン、ラサギリン類のシグナル検出による副作用比較

冷 傲, 田 雨時, 淺野 遥香, 浅野 弘斗, 周 怡, 高木 達也

日本薬学会年会要旨集　Vol. 138年会　No. 4　p. 54-54　2018/03

抗デングウイルスのHTS & In Silico医薬品設計

松田 仁志, 川下 理日人, 田 雨時, 高木 達也

日本薬学会年会要旨集　Vol. 138年会　No. 3　p. 184-184　2018/03

Dengue virus and its inhibitors: A brief review

Yu-Shi Tian, Yi Zhou, Tatsuya Takagi, Masanori Kameoka, Norihito Kawashita

Chemical and Pharmaceutical Bulletin　Vol. 66　No. 3　p. 191-206　2018

Both high and low plasma glutamine levels predict mortality in critically ill patients

Takae Tsujimoto, Kentaro Shimizu, Nobuaki Hata, Tatsuya Takagi, Etsuko Uejima, Hiroshi Ogura, Masafumi Wasa, Takeshi Shimazu

Surgery Today　Vol. 47　No. 11　p. 1331-1338　2017/11/01　Research paper (scientific journal)

A New Approach for Determining Short-Term, Objective Prognostic Predictive Methods for Terminal Cancer Patients Based on the Change Point of Laboratory Test Values

Kazuyuki Niki, Yoshiaki Okamoto, Yoshitaka Tabata, Mamiko Tsugane, Taizo Murata, Masao Mizuki, Yasushi Matsumura, Tatsuya Takagi, Etsuko Uejima

JOURNAL OF PALLIATIVE MEDICINE　Vol. 21　No. 4　p. 529-532　2017/11　Research paper (scientific journal)

Identification of claudin-4 binder that attenuates tight junction barrier function by TR-FRET-based screening assay

Akihiro Watari, Miki Kodaka, Koji Matsuhisa, Yuta Sakamoto, Kota Hisaie, Norihito Kawashita, Tatsuya Takagi, Yoshiaki Yamagishi, Hidehiko Suzuki, Hirofumi Tsujino, Kiyohito Yagi, Masuo Kondoh

SCIENTIFIC REPORTS　Vol. 7　2017/11　Research paper (scientific journal)

Characterization of H5N1 influenza virus variants with HA mutations diversified in human airway epithelial cells as minor variants

Watanabe Y, Arai Y, Kawashita N, Kawashita N, Daidoji T, Elgendy M E, Ibrahim MS, Kajiwara J, Hiramatsu H, Takagi T, Takahashi K, Shioda T, Suzuki Y, Nakaya T

2017/10

Desirable Information of Opioids for Families of Patients With Terminal Cancer: The Bereaved Family Members' Experiences and Recommendations

Yoshiaki Okamoto, Satoru Tsuneto, Tatsuya Morita, Tatsuya Takagi, Megumi Shimizu, Mitsunori Miyashita, Etsuko Uejima, Yasuo Shima

AMERICAN JOURNAL OF HOSPICE & PALLIATIVE MEDICINE　Vol. 34　No. 3　p. 248-253　2017/04　Research paper (scientific journal)

Identification of polymerase gene mutations that affect viral replication in H5N1 influenza viruses isolated from pigeons

Emad Mohamed Elgendy, Yasuha Arai, Norihito Kawashita, Tomo Daidoji, Tatsuya Takagi, Madiha Salah Ibrahim, Takaaki Nakaya, Yohei Watanabe

JOURNAL OF GENERAL VIROLOGY　Vol. 98　No. 1　p. 6-17　2017/01　Research paper (scientific journal)

Classification of Alzheimer’s disease and Parkinson’s disease using a support vector machine and probabilistic outputs

Asuka Hatabu, Masafumi Harada, Yoshitake Takahashi, Shunsuke Watanabe, Kenya Sakamoto, Kousuke Okamoto, Norihito Kawashita, Yu-Shi Tian, Tatsuya Takagi

Chem-Bio Informatics Journal　Vol. 17　p. 112-124　2017　Research paper (scientific journal)

Novel Concepts for Drug Hypersensitivity Based on the Use of Long-Time Scale Molecular Dynamic Simulation

Takahiro Murai, Norihito Kawashita, Yu-Shi Tian, Tatsuya Takagi

Journal of Pharmaceutics　Vol. 2016　No. 9520361　p. 1-6　2016/11　Research paper (scientific journal)

状態空間モデルによるサリドマイド製剤安全管理手順(TERMS)における患者対象調査の時系列データ解析

加藤平太, 白國優子, 川下理日人, 田雨時, 高木達也, 那須正夫

社会薬学　Vol. 35　No. Supplement　p. 111-111　2016/08/29

In silico analysis of enantioselective binding of immunomodulatory imide drugs to cereblon

Takahiro Murai, Norihito Kawashita, Yu-Shi Tian, Tatsuya Takagi

SPRINGERPLUS　Vol. 5　2016/07　Research paper (scientific journal)

Novel Polymerase Gene Mutations for Human Adaptation in Clinical Isolates of Avian H5N1 Influenza Viruses

Yasuha Arai, Norihito Kawashita, Tomo Daidoji, Madiha S. Ibrahim, Emad M. El-Gendy, Tatsuya Takagi, Kazuo Takahashi, Yasuo Suzuki, Kazuyoshi Ikuta, Takaaki Nakaya, Tatsuo Shioda, Yohei Watanabe

PLOS Pathogens　2016/06　Research paper (scientific journal)

Novel Concepts for Drug Hypersensitivity Based on the Use of Long-Time Scale Molecular Dynamic Simulation

Murai Takahiro, Kawashita Norihito, Tian Yu-Shi, Takagi Tatsuya

JOURNAL OF PHARMACEUTICS　Vol. 2016　p. 9520361-9520361　2016　Research paper (scientific journal)

Risk Management of Teratogenic Drugs similar to The Current States of Practice in Europe, US and Japan similar to

Tatsuya Takagi, Carla van Bennekom, Steffen Amann, Chizuko Hattori, Yuko Shirakuni, Tsugumichi Sato, Masao Nasu

YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN　Vol. 135　No. 10　p. 1161-1168　2015/10

SPECT脳血流画像に基づく機械学習を用いた疾患判別予測モデルの構築

阪本 健也, 幡生 あすか, 高木 達也, 岡本 晃典

核医学　Vol. 52　No. 3　p. 278-278　2015/09

Pharmacophore Modeling and Molecular Docking Studies of potential inhibitors to E6 PBM-PDZ from Human Papilloma Virus (HPV).

Yu-Shi Tian, Norihito Kawashita, Yuki Arai, Kousuke Okamoto, Tatsuya Takagi

Bioinformation　Vol. 11　No. 8　p. 401-6　2015/08　Research paper (scientific journal)

Pharmacophore Modeling and Molecular Docking Studies of potential inhibitors to E6 PBM-PDZ from Human Papilloma Virus (HPV).

Yu-Shi Tian, Norihito Kawashita, Yuki Arai, Kousuke Okamoto, Tatsuya Takagi

Bioinformation　Vol. 11　No. 8　p. 401-406　2015/08　Research paper (scientific journal)

Cutaneous exposure to agglomerates of silica nanoparticles and allergen results in IgE-biased immune response and increased sensitivity to anaphylaxis in mice

Toshiro Hirai, Yasuo Yoshioka, Hideki Takahashi, Ko-ichi Ichihashi, Asako Udaka, Takahide Mori, Nobuo Nishijima, Tokuyuki Yoshida, Kazuya Nagano, Haruhiko Kamada, Shin-ichi Tsunoda, Tatsuya Takagi, Ken J. Ishii, Hiromi Nabeshi, Tomoaki Yoshikawa, Kazuma Higashisaka, Yasuo Tsutsumi

PARTICLE AND FIBRE TOXICOLOGY　Vol. 12　No. 1　2015/06　Research paper (scientific journal)

Search for Low Molecular Weight Compounds that Inhibit Human Immunodeficiency Virus Type 1 Replication.

Chris Verathamjamras, Yu-Shi Tian, Norihito Kawashita, Kousuke Okamoto, Teruo Yasunaga, Kazuyoshi Ikuta, Kazushi Motomura, Naokazu Takeda, Tatsuya Takagi, Masanori Kameoka

J. Infect. Dis. Ther.　Vol. 3　No. 3　p. 1-8　2015/05　Research paper (scientific journal)

Oxidative Rearrangement of Cyclobutanone Derived N,O-Ketals Leading to Pyrrolidone Derivatives

Kenichi Murai, Daisuke Endo, Norihito Kawashita, Tatsuya Takagi, Hiromichi Fujioka

CHEMICAL & PHARMACEUTICAL BULLETIN　Vol. 63　No. 4　p. 245-247　2015/04　Research paper (scientific journal)

Characterization of H5N1 Influenza Virus Variants with Hemagglutinin Mutations Isolated from Patients

Yohei Watanabe, Yasuha Arai, Tomo Daidoji, Norihito Kawashita, Madiha S. Ibrahim, Emad El-Din M. El-Gendy, Hiroaki Hiramatsu, Ritsuko Kubota-Koketsu, Tatsuya Takagi, Takeomi Murata, Kazuo Takahashi, Yoshinobu Okuno, Takaaki Nakaya, Yasuo Suzuki, Kazuyoshi Ikuta

MBIO　Vol. 6　No. 2　p. e00081-e00081-15　2015/03　Research paper (scientific journal)

L-glutamine decreases the severity of mucositis induced by chemoradiotherapy in patients with locally advanced head and neck cancer: A double-blind, randomized, placebo-controlled trial

Takae Tsujimoto, Yoshifumi Yamamoto, Masafumi Wasa, Yukinori Takenaka, Susumu Nakahara, Tastuya Takagi, Mamiko Tsugane, Noriyuki Hayashi, Kazuhisa Maeda, Hidenori Inohara, Etsuko Uejima, Toshinori Ito

ONCOLOGY REPORTS　Vol. 33　No. 1　p. 33-39　2015/01　Research paper (scientific journal)

頭頸部癌の化学放射線療法下の口腔粘膜障害に対するグルタミンの有用性に関する臨床研究

辻本貴江, 山本佳史, 和佐勝史, 竹中幸則, 中原晋, 高木達也, 津金麻美子, 林紀行, 前田和久, 猪原秀典, 上島悦子, 伊藤壽記

外科と代謝・栄養　Vol. 48　No. 3　p. 57-57　2014/06/15　Research paper (conference, symposium, etc.)

A double-blind, randomized, placebo-controlled trial of I-glutamine for the severe oral mucositis induced by chemoradiotherapy in patients with locally advanced head and neck cancer.

Takae Tsujimoto, Yoshifumi Yamamoto, Masafumi Wasa, Yukinori Takenaka, Wataru Nakahara, Tatsuya Takagi, Mamiko Tsugane, Noriyuki Hayashi, Kazuhisa Maeda, Hidenori Inohara, Etsuko Uejima, Toshinori Ito

JOURNAL OF CLINICAL ONCOLOGY　Vol. 32　No. 15　2014/05

A small compound targeting the interaction between nonstructural proteins 2B and 3 inhibits dengue virus replication

Sabar Pambudi, Norihito Kawashita, Supranee Phanthanawiboon, Magot Diata Omokoko, Promsin Masrinoul, Akifumi Yamashita, Kriengsak Limkittikul, Teruo Yasunaga, Tatsuya Takagi, Kazuyoshi Ikuta, Takeshi Kurosu

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 440　No. 3　p. 393-398　2013/10　Research paper (scientific journal)

A Practical Estimation Method for Analyzing Adverse Drug Reactions Using Data Mining

Yuko Shirakuni, Kousuke Okamoto, Etuko Uejima, Shigeki Inui, Jun-Ichi Takahara, Takanori Ohgaru, Hiroyuki Yamasaki, Yushi Tian, Norihito Kawashita, Ran Inoue, Teruo Yasunaga, Tatsuya Takagi

Drug Information Journal　Vol. 47　No. 2　p. 235-241　2013　Research paper (scientific journal)

A Retrospective Chart Review of Terminal Patients with Cancer with Agitation and Their Risk Factors

Mie Nagase, Yoshiaki Okamoto, Satoru Tsuneto, Hitoshi Tanimukai, Yoichi Matsuda, Nao Okishiro, Yumiko Oono, Mamiko Tsugane, Tatsuya Takagi, Etsuko Uejima

JOURNAL OF PALLIATIVE MEDICINE　Vol. 15　No. 11　p. 1185-1190　2012/11　Research paper (scientific journal)

Antigenic analysis of highly pathogenic avian influenza virus H5N1 sublineages co-circulating in Egypt

Yohei Watanabe, Madiha S. Ibrahim, Hany F. Ellakany, Norihito Kawashita, Tomo Daidoji, Tatsuya Takagi, Teruo Yasunaga, Takaaki Nakaya, Kazuyoshi Ikuta

JOURNAL OF GENERAL VIROLOGY　Vol. 93　p. 2215-2226　2012/10　Research paper (scientific journal)

Predictive factors for postherpetic neuralgia using ordered logistic regression analysis.

Yuko Kanbayashi, Keiko Onishi, Keita Fukazawa, Kousuke Okamoto, Hiroshi Ueno, Tatsuya Takagi, Toyoshi Hosokawa

The Clinical journal of pain　Vol. 28　No. 8　p. 712-4　2012/10　Research paper (scientific journal)

Compliance Survey for Thalidomide Safety Use (part5); after Revision of TERMS

Yuko Shirakuni, Chizuko Hattori, Nobuyasu Yamaguchi, Teruyoshi Kubo, Norihito Kawashita, Tatsuya Takagi, Masao Nasu

PHARMACOEPIDEMIOLOGY AND DRUG SAFETY　Vol. 21　p. 208-208　2012/08

In search for a new anti-HIV-1 drug through inhibition of CA-CypA interaction

C. Verathamjamras, Y. -S. Tian, T. Yasunaga, T. Takagi, N. Kawashita, M. Kameoka

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES　Vol. 16　p. E194-E194　2012/06　Research paper (international conference proceedings)

Effects of indole on drug resistance and virulence of Salmonella enterica serovar Typhimurium revealed by genome-wide analyses

Eiji Nikaido, Etienne Giraud, Sylvie Baucheron, Suguru Yamasaki, Agnes Wiedemann, Kousuke Okamoto, Tatsuya Takagi, Akihito Yamaguchi, Axel Cloeckaert, Kunihiko Nishino

GUT PATHOGENS　Vol. 4　2012/05　Research paper (scientific journal)

アミノ酸と臨床栄養 救命センター症例におけるアミノ酸分析の検討 血漿グルタミン値の予後因子としての意義 急性肝不全症例におけるアミノ酸分析の検討

辻本 貴江, 廣瀬 智也, 清水 健太郎, 小倉 裕司, 畑 伸顕, 曹 英樹, 高木 達也, 和佐 勝史, 福澤 正洋, 嶋津 岳士, 上島 悦子

アミノ酸研究　Vol. 5　No. 2　p. 93-93　2012/03

Recent Advances in the Development of Small-Molecule Compounds Targeting HIV- 1 gp41 as Membrane Fusion Inhibitors

Norihito Kawashita, Yu-Shi Tian, U. Chandimal de Silva, Kousuke Okamoto, Tatsuya Takagi

Mini-Reviews in Organic Chemistry　Vol. 9　No. 1　p. 20-26　2012/02/01　Research paper (scientific journal)

Density-Functional Theory Calculation of acetal hydrolysis under mild conditions

Takahashi Ryosuke, Kawashita Norihito, Maegawa Tomohiro, Takagi Tatsuya, Fujioka Hiromichi

Proceedings of the Symposium on Chemoinformatics　Vol. 2012　p. P12-P12　2012

The hazard identification of amorphous nanosilica particles following dermal applications using the atopic dermatitis model mouse

HIRAI Toshiro, YOSHIOKA Yasuo, ICHIHASHI Ko-ichi, TAKAHASHI Hideki, YOSHIDA Tokuyuki, TAKAGI Tatsuya, TSUNODA Shin-ichi, NABESHI Hiromi, YOSHIKAWA Tomoaki, TSUTSUMI Yasuo

Annual Meeting of the Japanese Society of Toxicology　Vol. 39　p. P-136　2012

欧州におけるサリドマイドのリスク管理プログラム

白國優子, 高木達也, 那須正夫

医薬ジャーナル　Vol. 48　No. 11　p. 2653-2658　2012　Research paper (scientific journal)

New structure descriptor in the structure-activity relationship study on the suppression of aryl hydrocarbon receptor transformation by anthraquinones

Masaya Kawase, Tadashi Saito, Teruo Yasunaga, Tatsuya Takagi, Itsuko Fukuda, Hitoshi Ashida

Food Science and Technology Research　Vol. 18　No. 2　p. 173-176　2012　Research paper (scientific journal)

Factors predicting requirement of high-dose transdermal fentanyl in opioid switching from oral morphine or oxycodone in patients with cancer pain.

Yuko Kanbayashi, Toyoshi Hosokawa, Kousuke Okamoto, Sawako Fujimoto, Hideyuki Konishi, Eigo Otsuji, Toshikazu Yoshikawa, Tatsuya Takagi, Tsuneharu Miki, Masafumi Taniwaki

The Clinical journal of pain　Vol. 27　No. 8　p. 664-7　2011/10　Research paper (scientific journal)

Compliance Survey for Thalidomide Use in Japan (Part3); Text Data Analysis of Patients' Comments

Tatsuya Takagi, Yuko Shirakuni, Kousuke Okamoto, Chizuko Hattori, Nobuyasu Yamaguchi, Masao Nasu

PHARMACOEPIDEMIOLOGY AND DRUG SAFETY　Vol. 20　p. S222-S223　2011/08

A Computational Approach to Search Active Peptides as Membrane Fusion Inhibitors of HIV-1

Tian Yu-Shi, Kawashita Norihito, Verathamjamras Chris, Okamoto Kousuke, Yasunaga Teruo, Kameoka Masanori, Takagi Tatsuya

ANTIVIRAL RESEARCH　Vol. 90　No. 2　p. A76-A77　2011/05

Acquisition of Human-Type Receptor Binding Specificity by New H5N1 Influenza Virus Sublineages during Their Emergence in Birds in Egypt

Yohei Watanabe, Madiha S. Ibrahim, Hany F. Ellakany, Norihito Kawashita, Rika Mizuike, Hiroaki Hiramatsu, Nogluk Sriwilaijaroen, Tatsuya Takagi, Yasuo Suzuki, Kazuyoshi Ikuta

PLOS PATHOGENS　Vol. 7　No. 5　2011/05　Research paper (scientific journal)

高用量メソトレキセート治療を受ける患者において、48時間後血中濃度のみが有害事象の予測因子か? 順序ロジスティック回帰分析を用いた統計学的検証

神林 祐子, 野村 憲一, 岡本 晃典, 松本 洋典, 堀池 重夫, 高木 達也, 谷脇 雅史

日本薬学会年会要旨集　Vol. 131年会　No. 4　p. 192-192　2011/03

Refinement of Boosting-ERDA for ordered categorical data and its application to QSAR analysis of multi-drug resistance agents

Yamasaki Hiroyuki, Nishibata Yoshihiko, Okamoto Kousuke, Takagi Tatsuya

Symposium on Chemical Information and Computer Sciences　Vol. 2011　p. P12-P12　2011

Introduction of a predictive model into evaluation system for environmental fate of chemicals

Takahara Yusuke, Okamoto Kousuke, kawashita Norihito, Takagi Tatsuya

Symposium on Chemical Information and Computer Sciences　Vol. 2011　p. P7-P7　2011

Disease classification with support vector machine

Hatabu Asuka, Harada Masafumi, Takahashi Yoshitake, Watanabe Shunsuke, Yamashita Noriyuki, Ito Yoshihiro, Okamoto Kousuke, Takagi Tatsuya

Proceedings of the Symposium on Chemoinformatics　Vol. 2011　No. 0　p. P22-P22　2011

Anionic polymer, poly(methyl vinyl ether-maleic anhydride)-coated beads-based capture of human influenza A and B virus (vol 17, pg 752, 2009)

Akikazu Sakudo, Koichi Baba, Megumi Tsukamoto, Atsuko Sugimoto, Takashi Okada, Takanori Kobayashi, Norihito Kawashita, Tatsuya Takagi, Kazuyoshi Ikuta

BIOORGANIC & MEDICINAL CHEMISTRY　Vol. 19　No. 2　p. 1010-1010　2011/01　Research paper (scientific journal)

A retrospective chart review of opioid-induced nausea and somnolence on commencement for cancer pain treatment

Yoshiaki Okamoto, Satoru Tsuneto, Mamiko Tsugane, Tatsuya Takagi, Etsuko Uejima

Journal of Opioid Management　Vol. 6　No. 6　p. 431-434　2010/11　Research paper (scientific journal)

Statistical examination to determine whether only 48-h value for serum concentration during high-dose methotrexate therapy is a predictor for clinical adverse events using ordered logistic regression analysis.

Yuko Kanbayashi, Kenichi Nomura, Kousuke Okamoto, Yosuke Matsumoto, Shigeo Horiike, Tatsuya Takagi, Masafumi Taniwaki

Annals of hematology　Vol. 89　No. 10　p. 965-9　2010/10　Research paper (scientific journal)

Statistical identification of predictors for peripheral neuropathy associated with administration of bortezomib, taxanes, oxaliplatin or vincristine using ordered logistic regression analysis.

Yuko Kanbayashi, Toyoshi Hosokawa, Kousuke Okamoto, Hideyuki Konishi, Eigo Otsuji, Toshikazu Yoshikawa, Tatsuya Takagi, Masafumi Taniwaki

Anti-cancer drugs　Vol. 21　No. 9　p. 877-81　2010/10　Research paper (scientific journal)

Design and evaluation of antiretroviral peptides corresponding to the C-terminal heptad repeat region (C-HR) of human immunodeficiency virus type 1 envelope glycoprotein gp41

Bongkot Soonthornsata, Yu-Shi Tian, Piraporn Utachee, Sompong Sapsutthipas, Panasda Isarangkura-na-ayuthaya, Wattana Auwanit, Tatsuya Takagi, Kazuyoshi Ikuta, Pathom Sawanpanyalert, Norihito Kawashita, Masanori Kameoka

VIROLOGY　Vol. 405　No. 1　p. 157-164　2010/09　Research paper (scientific journal)

Can Anti-Infective Drugs Improve the Infection-Related Symptoms of Patients with Cancer during the Terminal Stages of Their Lives?

Sari Nakagawa, Yoshie Toya, Yoshiaki Okamoto, Satoru Tsuneto, Sho Goya, Hitoshi Tanimukai, Yoichi Matsuda, Yumiko Ohno, Hiroshi Eto, Mamiko Tsugane, Tatsuya Takagi, Etsuko Uejima

JOURNAL OF PALLIATIVE MEDICINE　Vol. 13　No. 5　p. 535-540　2010/05　Research paper (scientific journal)

抗がん剤の薬物相互作用予測に向けた薬物代謝酵素CYP3A4リガンドのファーマコフォア3D-QSAR解析

神林 祐子, 山崎 大典, 古谷 和春, 岡本 晃典, 高木 達也, 稲野辺 厚, 倉智 嘉久

日本薬学会年会要旨集　Vol. 130年会　No. 2　p. 257-257　2010/03

Highly conserved sequences for human neutralization epitope on hemagglutinin of influenza A viruses H3N2, H1N1 and H5N1: Implication for human monoclonal antibody recognition

Akifumi Yamashita, Norihito Kawashita, Ritsuko Kubota-Koketsu, Yuji Inoue, Yohei Watanabe, Madiha S. Ibrahim, Shoji Ideno, Mikihiro Yunoki, Yoshinobu Okuno, Tatsuya Takagi, Teruo Yasunaga, Kazuyoshi Ikuta

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 393　No. 4　p. 614-618　2010/03　Research paper (scientific journal)

Structure of the Prion Protein and Its Gene: An Analysis Using Bioinformatics and Computer Simulation

Akikazu Sakudo, Guangai Xue, Norihito Kawashita, Yasuhisa Ano, Tatsuya Takagi, Hideharu Shintani, Yasuharu Tanaka, Takashi Onodera, Kazuyoshi Ikuta

CURRENT PROTEIN & PEPTIDE SCIENCE　Vol. 11　No. 2　p. 166-179　2010/03

Development of evolved regression discriminant analysis combined ensemble learning for ordered categorical data

Yamasaki Hiroyuki, Okamoto Kousuke, Takagi Tatsuya

Symposium on Chemical Information and Computer Sciences　Vol. 2010　p. JP04-JP04　2010

Data Analysis of Severe Adverse Events using FDA AERS database

Inoue Ran, Shirakuni Yuuko, Kawasita Norihito, Okamoto Kousuke, Takagi Tatuya

Symposium on Chemical Information and Computer Sciences　Vol. 2010　p. JP08-JP08　2010

Ecotoxicity Prediction Using 3D Descriptors

Shinnosuke Hidaka, Hiroaki Shiraishi, Yoshihiro Ohmayu, Hiroyuki Yamasaki, Kousuke Okamoto, Norihito Kawashita, Teruo Yasunaga, Tatsuya Takagi

Journal of Computer Aided Chemistry　Vol. 11　p. 11-18　2010　Research paper (scientific journal)

Ethnic difference in patients with type 2 diabetes mellitus in inter-East Asian populations: A systematic review and meta-analysis focusing on gene polymorphism

Masakazu Takeuchi, Kousuke Okamoto, Tatsuya Takagi, Hitoshi Ishii

JOURNAL OF DIABETES　Vol. 1　No. 4　p. 255-262　2009/12　Research paper (scientific journal)

Anionic polymer, poly(methyl vinyl ether-maleic anhydride)-coated beads-based capture of human influenza A and B virus.

Akikazu Sakudo, Koichi Baba, Megumi Tsukamoto, Atsuko Sugimoto, Takashi Okada, Takanori Kobayashi, Norihito Kawashita, Tatsuya Takagi, Kazuyoshi Ikuta

Bioorganic & medicinal chemistry　Vol. 17　No. 2　p. 752-7　2009/01/15　Research paper (scientific journal)

Study on methods for factorial analyses and information extractions from adverse effects database

Okui Tomoko, Inoue Ran, Tsuyuri Shouhei, Shirakuni Yuko, Kawashita Norihito, Okamoto Kousuke, Takagi Tatsuya

Proceedings of the Symposium on Chemoinformatics　Vol. 2009　p. P17-P17　2009

Application of new nonparametric regression

Yonekura Satoshi, Okamoto Kousuke, Kawashita Norihito, Hidaka Shinnosuke, Yamasaki Hiroyuki, Kawase Masaya, Takagi Tatsuya

Proceedings of the Symposium on Chemoinformatics　Vol. 2009　p. O2-O2　2009

A QSAR Study using GA-PLS on anti-HIV-1 Small Molecules Targeting Cyclophilin A

Tian Yushi, Norihito Kawashita, Rie Kashiwada, Hiromasa Sugimoto, Teruo Yasunaga, Kousuke Okamoto, Tatsuya Takagi

PLS '09: PROCEEDINGS OF THE 6TH INTERNATIONAL CONFERENCE ON PARTIAL LEAST SQUARES AND RELATED METHODS　p. 334-337　2009　Research paper (international conference proceedings)

Signal Detection of Drug Complications Applying Association Rule Learning for Stevens-Johnson Syndrome

Yuko Shirakuni, Kousuke Okamoto, Norihito Kawashita, Teruo Yasunaga, Tatsuya Takagi

Journal of Computer Aided Chemistry　Vol. 10, 118-127　p. 118-127　2009　Research paper (scientific journal)

細菌数測定法における誤差分布の推定

岡本晃典, 山口進康, 馬場貴志, 高木達也, 那須正夫

医薬品研究　Vol. 40　No. 1　p. 1-8　2009　Research paper (scientific journal)

Statistical Study on Chemical Risk Factors for SJS/TEN

Y. Shirakuni, E. Uejima, J. Takahara, K. Okamoto, N. Kawashita, T. Yasunaga, S. Inui, T. Takagi

DRUG SAFETY　Vol. 32　No. 10　p. 920-920　2009

Compliance Survey for Thalidomide use in Japan

T. Takagi, C. Hattori, K. Okamoto, Y. Shirakuni, N. Yamaguchi, M. Nasu

DRUG SAFETY　Vol. 32　No. 10　p. 887-887　2009

Prediction for Biodegradability of Chemicals by Kernel Partial Least Squares

Koichi Hiromatsu, Jun-ichi Takahara, Tsutomu Nishihara, Kousuke Okamoto, Teruo Yasunaga, Yoshihiro Ohmayu, Tatsuya Takagi, Kingo Nakazono

Journal of Computer Aided Chemistry　Vol. 10　p. 1-9　2009　Research paper (scientific journal)

Risk factors for infection in haematology patients treated with rituximab

Yuko Kanbayashi, Kenichi Nomura, Yoshiko Fujimoto, Mihoko Yamashita, Muneo Ohshiro, Kousuke Okamoto, Yosuke Matsumoto, Shigeo Horiike, Tatsuya Takagi, Yoji Ishida, Masafumi Taniwaki

EUROPEAN JOURNAL OF HAEMATOLOGY　Vol. 82　No. 1　p. 26-30　2009/01　Research paper (scientific journal)

Statistical validation of the relationships of cancer pain relief with various factors using ordered logistic regression analysis

Yuko Kanbayashi, Kousuke Okamoto, Takanori Ogaru, Toyoshi Hosokawa, Tatsuya Takagi

Clinical Journal of Pain　Vol. 25　No. 1　p. 65-72　2009　Research paper (scientific journal)

Ethnic difference in inter-East Asian subjects with normal glucose tolerance and impaired glucose regulation: A systematic review and meta-analysis focusing on fasting serum insulin

Masakazu Takeuchi, Kousuke Okamoto, Tatsuya Takagi, Hitoshi Ishii

DIABETES RESEARCH AND CLINICAL PRACTICE　Vol. 82　No. 3　p. 383-390　2008/12　Research paper (scientific journal)

イトラコナゾールシロップの母集団薬物動態解析 深在性真菌症予防としての至適用量の検討

神林 祐子, 野村 憲一, 高木 達也, 谷脇 雅史

感染症学雑誌　Vol. 82　No. 5　p. 590-590　2008/09

発熱性好中球減少症予防としてのイトラコナゾールシロップの母集団薬物動態解析

大城 宗生, 野村 憲一, 神林 祐子, 藤本 佳子, 岡本 晃典, 高木 達也, 谷脇 雅史

臨床血液　Vol. 49　No. 9　p. 1181-1181　2008/09

Ethnic difference in patients with type 2 diabetes mellitus in inter-East Asian populations: A systematic review and meta-analysis focusing on fasting serum insulin

Masakazu Takeuchi, Kousuke Okamoto, Tatsuya Takagi, Hitoshi Ishii

DIABETES RESEARCH AND CLINICAL PRACTICE　Vol. 81　No. 3　p. 370-376　2008/09　Research paper (scientific journal)

Population pharmacokinetics of itraconazole solution used as prophylaxis for febrile neutropenia

Yuko Kanbayashi, Kenichi Nomura, Yoshiko Fujimoto, Kazuho Shimura, Daisuke Shimizu, Kousuke Okamoto, Yosuke Matsumoto, Shigeo Horiike, Chihiro Shimazaki, Tatsuya Takagi, Masafumi Taniwaki

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS　Vol. 31　No. 5　p. 452-457　2008/05　Research paper (scientific journal)

Computational studies of gp41 6-helix bundle: Do stabilized energy of HIV membrane fusion inhibitor C34 and interaction energy of gp41 6-helix bundle have good correlation with their inhibitory activity?

Norihito Kawashita, Yu-Shi Tian, Masashi Yasuda, U. Chandimal de Silva, Rie Kashiwada, Shota Nakamura, Naohisa Goto, Rika Nishikiori, Kousuke Okamoto, Masanori Kameoka, Teruo Yasunaga, Masaya Kawase, Kazuyoshi Ikuta, Tatsuya Takagi

ANTIVIRAL RESEARCH　Vol. 78　No. 2　p. A42-A42　2008/05

Enhancement of ordinal CoMFA by ridge logistic partial least squares

Takanori Ohgaru, Ryo Shimizu, Kosuke Okamoto, Norihito Kawashita, Masaya Kawase, Yuko Shirakuni, Rika Nishikiori, Tatsuya Takagi

JOURNAL OF CHEMICAL INFORMATION AND MODELING　Vol. 48　No. 4　p. 910-917　2008/04　Research paper (scientific journal)

イトラコナゾールシロップの母集団薬物動態解析 深在性真菌症予防としての至適用量の検討

神林 祐子, 野村 憲一, 高木 達也, 谷脇 雅史

感染症学雑誌　Vol. 82　No. 臨増　p. 281-281　2008/03

Structural requirements for the stability of novel cephalosporins to AmpC β-lactamase based on 3D-structure

Kenji Murano, Toshio Yamanaka, Ayako Toda, Hidenori Ohki, Shinya Okuda, Kohji Kawabata, Kazuo Hatano, Shinobu Takeda, Hisashi Akamatsu, Kenji Itoh, Keiji Misumi, Satoshi Inoue, Tatsuya Takagi

Bioorganic & Medicinal Chemistry　Vol. 16　No. 5　p. 2261-2275　2008/03　Research paper (scientific journal)

Application of partial least square on quantitative analysis of L-, D-, and DL-tartaric acid by terahertz absorption spectra

Rika Nishikiori, Mariko Yamaguchi, Keisuke Takano, Tokujiro Enatsu, Masahiko Tani, U. Chandimal de Silva, Norihito Kawashita, Tatsuya Takagi, Shotaro Morimoto, Masanori Hangyo, Masaya Kawase

CHEMICAL & PHARMACEUTICAL BULLETIN　Vol. 56　No. 3　p. 305-307　2008/03　Research paper (scientific journal)

Development of Fingerprint Verification Type Self-Organized Map Applied to Profiling Seized Methamphetamine

Rika Nishikiori, Yukiko Makino, Yukino Ochi, Noriyuki Yamashita, Kousuke Okamoto, Norihito Kawashita, Junichi Takahara, Teruo Yasunaga, Tatsuya Takagi, Masaya Kawase

Journal of Computer Aided Chemistry　Vol. 9　p. 30-36　2008　Research paper (scientific journal)

Ordinal classification using comparative molecular field analysis

Takanori Ohgaru, Ryo Shimizu, Kousuke Okamoto, Masaya Kawase, Yuko Shirakuni, Rika Nishikiori, Tatsuya Takagi

JOURNAL OF CHEMICAL INFORMATION AND MODELING　Vol. 48　No. 1　p. 207-212　2008/01　Research paper (scientific journal)

Ascorbic acid transported by sodium-dependent vitamin C transporter 2 stimulates steroidogenesis in human choriocarcinoma cells

Ximei Wu, Takuma Iguchi, Norio Itoh, Kousuke Okamoto, Tatsuya Takagi, Keiichi Tanaka, Tsuyoshi Nakanishi

ENDOCRINOLOGY　Vol. 149　No. 1　p. 73-83　2008/01　Research paper (scientific journal)

Comparison of antiemetic efficacy of 5-HT3 receptor antagonists in orthopedics cancer patients receiving high-dose chemotherapy

Miki Takenaka, Yoshiaki Okamoto, Kenji Ikeda, Ryo Hashimoto, Takafumi Ueda, Nobuo Kurokawa, Tatsuya Takagi, Etsuko Uejima

Gan To Kagaku Ryoho　Vol. 34　No. 3　p. 403-407　2007/03　Research paper (scientific journal)

Computational Studies on Relationship with Protein-Protein Interaction Energy of HIV-1 gp41 and Its Inhibitory Activity of Membrane Fusion

Kawashita, N, Tian, Y.-s, Nakamura, S, Kawaguchi, A, Yamashita, N, Okamoto, K, de Silva, U. C, Kameoka, M, Yasunaga, T, Ikuta, K, Takagi, T

2007/01

Reciprocating dialysis tube method: Periodic tapping improved in vitro release/dissolution testing of suppositories

Soichi Itoh, Naomi Teraoka, Toshio Matsuda, Kousuke Okamoto, Tatsuya Takagi, Charles Oo, H. Danny Kao

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS　Vol. 64　No. 3　p. 393-398　2006/11　Research paper (scientific journal)

Statistical Methods Used to Determine Drug Consumption in New Hospice Ward

Yuko Shirakuni, Kousuke Okamoto, Masamichi Sugimoto, Takashi Okazawa, Tatsuya Takagi

Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences)　Vol. 32　No. 9　p. 882-889　2006/09　Research paper (scientific journal)

New computer-intensive procedures for testing null hypotheses comparing two parameters approximately

K Okamoto, M Higashi, M Yokota, R Nishikiori, M Osaki, T Yasunaga, T Takagi

CHEMOMETRICS AND INTELLIGENT LABORATORY SYSTEMS　Vol. 82　No. 1-2　p. 66-74　2006/05　Research paper (scientific journal)

Note in statistical treatment of medical and pharmaceutical data

M Kawase, H Konishi, K Yagi, R Nishikiori, T Takagi

JOURNAL OF BIOSCIENCE AND BIOENGINEERING　Vol. 100　No. 1　p. 116-118　2005/07　Research paper (scientific journal)

多重比較入門

高木 達也, 岡本 晃典

日本化学会情報化学部会誌　Vol. 23　No. 1　p. 2-2　2005

Application of revised version of neural independent component analysis to classification problems of confiscated methamphetamine

T Takagi, Y Makino, Y Tanaka, K Okamoto, N Yamashita, T Matsumoto, M Yokota, K Kurokawa, T Yasunaga

CHEMICAL & PHARMACEUTICAL BULLETIN　Vol. 52　No. 12　p. 1427-1432　2004/12　Research paper (scientific journal)

A New Procedure of Validation for Binary Tree Models using Resampling Technique

Tatsuya TAKAGI, Kousuke OKAMOTO, Masahiko YOKOTA, Teruo YASUNAGA

Journal of Computer Aided Chemistry　Vol. 5　p. 35-46　2004　Research paper (scientific journal)

Bacterial activity and community composition in stream water and biofilm from an urban river determined by fluorescent in situ hybridization and DGGE analysis

Ruben Araya, Katsuji Tani, Tatsuya Takagi, Nobuyasu Yamaguchi, Masao Nasu

FEMS Microbiology Ecology　Vol. 43　No. 1　p. 111-119　2003/02/01　Research paper (scientific journal)

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TAKAGI Tatsuya

CICSJ Bulletin　Vol. 21　No. 4　p. 76-76　2003

A New Multiple Comparison Method Using Resampling Technique for Medical, Pharmaceutical, and Chemical Data

Tatsuya Takagi, Kousuke Okamoto, Yumiko Yokogawa, Masahiko Yokota, Ken Kurokawa, Teruo Yasunaga

Journal of Computer Aided Chemistry　Vol. 4　p. 27-34　2003　Research paper (scientific journal)

FISH analysis of 142 EGFP transgene integration sites into the mouse genome

T Nakanishi, A Kuroiwa, S Yamada, A Isotani, A Yamashita, A Tairaka, T Hayashi, T Takagi, M Ikawa, Y Matsuda, M Okabe

GENOMICS　Vol. 80　No. 6　p. 564-574　2002/12　Research paper (scientific journal)

The Comparison of Generalized Additive Model with Artificial Hierarchical Neural Network in the Analysis of Pharmaceutical Data

Tatsuya Takagi, Emiko Kurokawa, Kouji Miyata, Kousuke Okamoto, Yuko Tanaka, Ken Kurokawa, Teruo Yasunaga

Journal of Computer Aided Chemistry　Vol. 3　p. 56-62　2002　Research paper (scientific journal)

Mutational analyses of cysteine residues of bovine dihydrodiol dehydrogenase 3

T Terada, N Fujita, H Adachi, H Nanjo, R Sato, T Takagi, M Maeda

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY　Vol. 1547　No. 1　p. 127-134　2001/05　Research paper (scientific journal)

Synthesis of stable analogs in blood and conformational analysis of arenastatin A, a potent cytotoxic spongean depsipeptide

N Murakami, S Tamura, WQ Wang, T Takagi, M Kobayashi

TETRAHEDRON　Vol. 57　No. 20　p. 4323-4336　2001/05　Research paper (scientific journal)

Site-directed mutagenesis studies of bovine liver cytosolic dihydrodiol dehydrogenase: the role of Asp-50, Tyr-55, Lys-84, His-117, Cys-145 and Cys-193 in enzymatic activity

T Terada, N Fujita, Y Sugihara, R Sato, T Takagi, M Maeda

CHEMICO-BIOLOGICAL INTERACTIONS　Vol. 130　No. 1-3　p. 833-845　2001/01　Research paper (scientific journal)

Characterization of a novel variant (S145C/L311V) of 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase in human liver

T Kume, H Iwasa, H Shiraishi, T Yokoi, K Nagashima, M Otsuka, T Terada, T Takagi, A Hara, T Kamataki

PHARMACOGENETICS　Vol. 9　No. 6　p. 763-771　1999/12　Research paper (scientific journal)

Solvation and nucleophilic reactivity of conjugate-base anions of 5-methyl Meldrum's acid and of 3,3-dimethylbarbituric acid in acetonitrile-methanol

Y Kondo, K Yano, M Urade, A Yamada, R Kouyama, T Takagi

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2　Vol. 1999　No. 6　p. 1181-1186　1999/06　Research paper (scientific journal)

Specific intramolecular interactions C-H center dot center dot center dot N in heteroaryl vinyl ethers and heteroaryl vinyl sulfides studied by H-1, C-13, and N-15 NMR spectroscopies and by ab initio calculations on molecular structures as well as on nuclear shieldings

AV Afonin, AV Vashchenko, T Takagi, A Kimura, H Fujiwara

CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE　Vol. 77　No. 4　p. 416-424　1999/04　Research paper (scientific journal)

Equations for Estimating Daily Energy Expenditure and Daily Activity Level Based on the Number of Steps Taken and Sleeping Time

NISHIHARA Teruyo, SAKAMOTO Mieko, OSHITA Ichiko, TAKAGI Tatsuya

The journal of science of labour　Vol. 75　No. 11　p. 409-420　1999　Research paper (scientific journal)

GeneAlign : Java Application Software for Multiple Sequence Alignment Editor

Ken Kurokawa, Yoshitaka Hasegawa, Kenichi Kawashima, Toshiyuki Okumura, Tatsuya Takagi, Teruo Yasunaga

Genome Informatics　Vol. 10　p. 208-209　1999　Research paper (scientific journal)

Solvation and nucleophilic reactivity of 1,2,4-triazolate ion in acetonitrile-methanol mixtures

Y Kondo, K Yano, O Fang, H Saito, T Takagi

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2　No. 8　p. 1827-1831　1998/08　Research paper (scientific journal)

Gene Web２: Sequence Analysis Tools on Web Server Using Java API.

Ken Kurokawa, Kenichi Kawashima, Toshiyuki Okumura, Tatsuya Takagi, Teruo Yasunaga

Genome Informatics Workshop　Vol. 1998　p. 236-237　1998　Research paper (scientific journal)

Slight difference in primary amino acid sequence of p17 matrix protein of HIV-1 exerts profound influence on its antigenicity

K Taniguchi, H Tsuchie, S Kageyama, M Iwasaki, T Takagi, F Sasao, S Ueda, T Kurimura

ARCHIVES OF VIROLOGY　Vol. 143　No. 5　p. 881-890　1998　Research paper (scientific journal)

A survey of genes expressed in mouse embryonal carcinoma F9 cells: Characterization of expressed sequence tags matching no known genes

M Nomura, S Nishiguchi, MA Motaleb, Y Takihara, T Takagi, T Yasunaga, K Shimada

JOURNAL OF BIOCHEMISTRY　Vol. 122　No. 1　p. 129-147　1997/07　Research paper (scientific journal)

Components of herbal ecstacies

T Takagi, S Kimoto, Y Makino, M Nasu

JAPANESE JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH　Vol. 43　No. 3　p. 197-201　1997/06　Research paper (scientific journal)

Cloning and expression of cDNA encoding bovine liver dihydrodiol dehydrogenase 3, DD3

T Terada, H Adachi, H Nanjo, N Fujita, T Takagi, J Nishikawa, M Imagawa, T Nishihara, M Maeda

ENZYMOLOGY AND MOLECULAR BIOLOGY OF CARBONYL METABOLISM 6　Vol. 414　p. 545-553　1997　Research paper (international conference proceedings)

Introduction of solvent-accessible surface area in the calculation of the hydrophobicity parameter log P from an atomistic approach

T Masuda, T Jikihara, K Nakamura, A Kimura, T Takagi, H Fujiwara

JOURNAL OF PHARMACEUTICAL SCIENCES　Vol. 86　No. 1　p. 57-63　1997/01　Research paper (scientific journal)

3D-quantitative structure-activity relationships for hydrophobic interactions: Comparative molecular field analysis (CoMFA) including molecular lipophilicity potentials as applied to the glycine conjugation of aromatic as well as aliphatic carboxylic acids

T Masuda, K Nakamura, T Jikihara, F Kasuya, K Igarashi, M Fukui, T Takagi, H Fujiwara

QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIPS　Vol. 15　No. 3　p. 194-200　1996/06　Research paper (scientific journal)

SOLVATION OF CARBOXYLATE IONS AND OF TRANSITION-STATE ANIONS FOR THE REACTION OF CARBOXYLATE ION WITH ETHYL IODIDE IN ACETONITRILE-METHANOL MIXTURES - THERMODYNAMIC AND QUANTUM-MECHANICAL APPROACHES

Y KONDO, W SUGITANI, M TOKUI, T TAKAGI

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2　No. 6　p. 1049-1054　1995/06　Research paper (scientific journal)

ANALYSIS OF CYCLIC FEED-INTAKE IN RATS FED ON A ZINC-DEFICIENT DIET AND THE LEVEL OF DIHYDROPYRIMIDINASE (EC-3.5.2.2)

N TAMAKI, S FUJIMOTOSAKATA, M KIKUGAWA, M KANEKO, S ONOSAKA, T TAKAGI

BRITISH JOURNAL OF NUTRITION　Vol. 73　No. 5　p. 711-722　1995/05　Research paper (scientific journal)

Developing Sequence Analysis Tools on Web Server

Yasunaga T., Takagi T., Takeuchi A., Niiyama T.

GI　Vol. 6　p. 164-165　1995

DEVELOPMENT OF AN APPLICATIONS FOR A SIMULATOR OF INTERMOLECULAR POTENTIALS .3. DEVELOPMENT OF SIMP/II AND SIMP/D AND THEIR APPLICATION

T TAKAGI, S MATSUO, A TANAKA, Y MOTOI, M TANI, H FUJIWARA, Y SASAKI

CHEMICAL & PHARMACEUTICAL BULLETIN　Vol. 42　No. 5　p. 1009-1015　1994/05　Research paper (scientific journal)

CHARACTERIZATION OF SOLUTE-SOLVENT INTERACTION AT THE TRANSITION-STATE BY THERMODYNAMIC AND QUANTUM-MECHANICAL APPROACHES - REACTIONS OF IMIDIDE IONS WITH ETHYL IODIDE IN ACETONITRILE-METHANOL

Y KONDO, O NONAKA, K IWASAKI, T KUWAMOTO, T TAKAGI

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2　Vol. 1994　No. 3　p. 473-477　1994/03　Research paper (scientific journal)

Menu System Based on NCSA Mosaic and Programs Forked from the Menu

Yasunaga T., Takagi T., Tokimori T., Kotani K., Takeuchi A., Niiyama T.

GI　Vol. 5　p. 216-217　1994　Research paper (international conference proceedings)

PURIFICATION, CHARACTERIZATION AND INHIBITION OF DIHYDROPYRIMIDINASE FROM RAT-LIVER

M KIKUGAWA, M KANEKO, S FUJIMOTOSAKATA, M MAEDA, K KAWASAKI, T TAKAGI, N TAMAKI

EUROPEAN JOURNAL OF BIOCHEMISTRY　Vol. 219　No. 1-2　p. 393-399　1994/01　Research paper (scientific journal)

SINGLE-ION ENTHALPIES OF TRANSFER FOR CONJUGATE-BASE ANIONS OF IMIDES IN ACETONITRILE-METHANOL MIXTURES - EMPIRICAL CORRELATION WITH SEMIEMPIRICAL MOLECULAR-ORBITAL CALCULATIONS

Y KONDO, O NONAKA, K IWASAKI, T KUWAMOTO, T TAKAGI

JOURNAL OF THE CHEMICAL SOCIETY-FARADAY TRANSACTIONS　Vol. 90　No. 1　p. 121-125　1994/01　Research paper (scientific journal)

REVISION OF THE DUAL SCALING METHOD FOR SUCCESSIVE CATEGORIES DATA AND ITS APPLICATION TO QUANTITATIVE STRUCTURE-ACTIVITY-RELATIONSHIPS (QSAR)

T TAKAGI, K TANGE, T JIKIHARA, N ONOZAWA, K SAKASHITA, H FUJIWARA, Y SASAKI

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN　Vol. 66　No. 12　p. 3606-3612　1993/12　Research paper (scientific journal)

Rational Estimation of the QSAR (Quantitative Structure-Activity Relationships) Descriptors .SIGMA.s.DEG., and Their Applications for Medicinals Now Available.

Yoshio SASAKI, Tatsuya TAKAGI, Hideko KAWAKI

CHEMICAL & PHARMACEUTICAL BULLETIN　Vol. 41　No. 3　p. 415-423　1993　Research paper (scientific journal)

Calculation of Recommendable Additional Exercise by Using simple Formula for Estimation of Daily Activity Factor(x)-Relation to Recommendod Daily Exercise-

Teruyo Nishihara, Ichiko Oshita, Tatsuya Takagi, Tsutomu Nishihara

The Japanese Journal of Nutrition and Dietetics　Vol. 51　No. 6　p. 341-350　1993　Research paper (scientific journal)

PARTITION-COEFFICIENTS IN A LIPOSOME WATER-SYSTEM - METHODS FOR DETERMINATION AND ERROR ANALYSIS

T TAKAGI, A KIMURA, YZ DA, H NAKAI, H FUJIWARA

ANALYTICAL SCIENCES　Vol. 8　No. 6　p. 761-765　1992/12　Research paper (scientific journal)

ON THE ESTIMATION OF THE QUANTITATIVE STRUCTURE-ACTIVITY-RELATIONSHIPS DESCRIPTOR SIGMA(S)CIRCLE FOR ALIPHATIC COMPOUND

Y SASAKI, T TAKAGI, H KAWAKI

CHEMICAL & PHARMACEUTICAL BULLETIN　Vol. 40　No. 3　p. 565-569　1992/03　Research paper (scientific journal)

Estimation of Daily Activity Factor(x)for Men Using a Simple Formula Based on Time and Motion Study.

NISHIHARA Teruyo, OSHITA Ichiko, TAKAGI Tatsuya, NASU Masao, NISHIHARA Tsutomu

Eiyo To Shokuryo　Vol. 45　No. 3　p. 227-237　1992

THE ENERGY ASPECT OF OIL-WATER PARTITION AND ITS APPLICATION TO THE ANALYSIS OF QUANTITATIVE STRUCTURE-ACTIVITY-RELATIONSHIPS - ALIPHATIC-ALCOHOLS IN THE LIPOSOME WATER PARTITION SYSTEM

Hideaki FUJIWARA, Y. Z. DA, Katsuhiko ITO, Tatsuya Takagi, Yukako Nishioka

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN　Vol. 64　No. 12　p. 3707-3712　1991/12　Research paper (scientific journal)

REVISED SUBSTITUENT ENTROPY CONSTANTS SIGMA-S-DEGREES FOR DISUBSTITUTED AND TRI-SUBSTITUTED BENZENE-DERIVATIVES, AND THEIR APPLICATIONS FOR SUBSTRATES HAVING 2 SUBSTITUTED PHENYL RINGS

Y SASAKI, T TAKAGI, H KAWAKI

CHEMICAL & PHARMACEUTICAL BULLETIN　Vol. 39　No. 11　p. 2775-2779　1991/11　Research paper (scientific journal)

REVISED INTERPRETATIONS OF ELECTRONIC SUBSTITUENT CONSTANTS USING ELECTRON NUMBER ANALYSIS AND MOLECULAR ELECTROSTATIC POTENTIAL

T TAKAGI, T KATAYAMA, M TANI, R TOKURA, A NODA, KI MATSUMURA, S NAGAI, H FUJIWARA, Y SASAKI

CHEMICAL & PHARMACEUTICAL BULLETIN　Vol. 39　No. 10　p. 2494-2497　1991/10　Research paper (scientific journal)

Molecular Structure and Smectic Properties: Thermal Properties of Some Liquid Crystals Having a Nitro Group at the Terminal Position

Yoshiaki Sakurai, Shunsuke Takenaka, Hisanori Sugiura, Shigekazu Kusabayashi, Yasuo Nishihata, Hikaru Terauchi, Tatsuya Takagi

Molecular Crystals and Liquid Crystals　Vol. 201　No. 1　p. 95-113　1991/06　Research paper (scientific journal)

PROCEDURES ON THE ESTIMATION OF THE NOVEL QUANTITATIVE STRUCTURE ACTIVITY RELATIONSHIP (QSAR) DESCRIPTOR SIGMA-SO FOR POLYSUBSTITUTED BENZENE SERIES, AND THEIR POLARIZABILITIES

Y SASAKI, H KAWAKI, T TAKAGI

CHEMICAL & PHARMACEUTICAL BULLETIN　Vol. 39　No. 2　p. 349-351　1991/02　Research paper (scientific journal)

協業の梨農園経営農家における労働,栄養,休養

林敏子, 大下市子, 山城ミヤ子, 西原照代, 高木達也, 那須正夫, 越河六郎

労働科学　Vol. 67　No. 6　p. 293-305　1991　Research paper (scientific journal)

A study on the inclusion phenomena occuring between crown ethers and alkaline metal cations using Monte Carlo simulations.

Tatsuya Takagi, Akihiro Noda, Hironobu Maezaki, Ken-Ichi Matsumura, Hideaki Fujiwara

BUNSEKI KAGAKU　Vol. 40　No. 8　p. 407-412　1991　Research paper (scientific journal)

SOLID-STATE CARBON-13 CP/MAS NMR SPECTRA OF 2,2 '-BI-1H-IMIDAZOLE

Satoru Takasu, Hitoshi Takai, Tatsuya Takagi, Hideaki Fujiwara

ANALYTICAL SCIENCES　Vol. 7　No. Suppl.　p. 845-846　1991　Research paper (scientific journal)

A Rough Estimation of the Activity Index (X) for Women by Simply Formula based on Time and Motion Study

Teruyo Nishihara, Chieko Tanaka, Ichiko Oshita, Toshiko Hayashi, Tatsuya Takagi, Masao Nasu

The Japanese Journal of Nutrition and Dietetics　Vol. 49　No. 3　p. 115-127　1991

MOLECULAR-STRUCTURE AND SMECTIC PROPERTIES - THE SUBSTITUENT EFFECT ON THE SMECTIC-A PHASE IN BIPHENYL ESTER SYSTEMS

H TAKEDA, Y SAKURAI, S TAKENAKA, H MIYAKE, T DOI, S KUSABAYASHI, T TAKAGI

JOURNAL OF THE CHEMICAL SOCIETY-FARADAY TRANSACTIONS　Vol. 86　No. 20　p. 3429-3435　1990/10　Research paper (scientific journal)

ESTIMATION OF THE QUANTITATIVE STRUCTURE ACTIVITY RELATIONSHIP DESCRIPTOR SIGMA-SO FOR DISUBSTITUTED AND TRI-SUBSTITUTED BENZENE-DERIVATIVES

Y SASAKI, H KAWAKI, T TAKAGI

CHEMICAL & PHARMACEUTICAL BULLETIN　Vol. 38　No. 9　p. 2344-2346　1990/09　Research paper (scientific journal)

NUCLEOPHILIC-SUBSTITUTION REACTIONS OF ALIPHATIC AND AROMATIC CARBOXYLATE IONS WITH ETHYL IODIDE - SPECIFIC INTERACTIONS AND ISOKINETIC RELATIONSHIPS IN ACETONITRILE METHANOL MIXTURES

Y KONDO, T FUJIWARA, A HAYASHI, S KUSABAYASHI, T TAKAGI

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2　Vol. 1990　No. 5　p. 741-746　1990/05　Research paper (scientific journal)

SOLUTE-STATIONARY PHASE INTERACTION IN GAS-LIQUID-CHROMATOGRAPHY - EVALUATION OF THE RELATIVE RETENTION VALUE FOR SUBSTITUTED HALOGENOBENZENE DERIVATIVES

Y SASAKI, T TAKAGI, H KAWAKI, S FUJII, F MASUDA

CHEMICAL & PHARMACEUTICAL BULLETIN　Vol. 38　No. 4　p. 948-950　1990/04　Research paper (scientific journal)

ON THE SOLUTE-STATIONARY PHASE INTERACTION IN GAS-LIQUID-CHROMATOGRAPHY - EVALUATION ON THE RELATIVE RETENTION VALUES FOR MONOALKYL-SUBSTITUTED AND POLYALKYL-SUBSTITUTED BENZENE-DERIVATIVES

Y SASAKI, H KAWAKI, T TAKAGI, T MURAKAMI, S FUJII, F MASUDA

CHEMICAL & PHARMACEUTICAL BULLETIN　Vol. 38　No. 3　p. 721-723　1990/03　Research paper (scientific journal)

THE SUBSTITUENT EFFECT ON THE THERMAL-STABILITY OF THE SMECTIC A PHASE IN PARA-PHENYLENE SYSTEMS INCORPORATING ESTER LINKAGES

S TAKENAKA, Y SAKURAI, H TAKEDA, T IKEMOTO, H MIYAKE, S KUSABAYASHI, T TAKAGI

MOLECULAR CRYSTALS AND LIQUID CRYSTALS　Vol. 178　p. 103-115　1990　Research paper (scientific journal)

The Substituent Effect on the Thermal Stability of the Smectic A Phase in para- Phenylene Systems Incorporating Ester Linkages

S. Takenaka, Y. Sakurai, H. Takeda, T. Ikemoto, H. Miyake, S. Kusabayashi, T. Takagi

Molecular Crystals and Liquid Crystals Incorporating Nonlinear Optics　Vol. 178　No. 1　p. 103-115　1990/01/01　Research paper (scientific journal)

DETERMINATION OF THE NOVEL QUANTITATIVE STRUCTURE-ACTIVITY-RELATIONSHIPS DESCRIPTOR-SIGMA-S0 FOR DISUBSTITUTED AND TRISUBSTITUTED BENZENE-DERIVATIVES

H KAWAKI, Y SASAKI, T TAKAGI, S FUJII, F MASUDA

CHEMICAL & PHARMACEUTICAL BULLETIN　Vol. 37　No. 12　p. 3268-3271　1989/12　Research paper (scientific journal)

NUCLEAR MAGNETIC-RESONANCE RELAXATION STUDY OF STRYCHNINE IN SOLUTION - MOLECULAR-DYNAMICS MODELS FOR THE INTERPRETATION OF C-13 T1 DATA AND RELAXATION MECHANISMS OF THE QUATERNARY CARBONS

H FUJIWARA, YZ DA, T TAKAGI, Y SASAKI

CHEMICAL & PHARMACEUTICAL BULLETIN　Vol. 37　No. 11　p. 2887-2891　1989/11　Research paper (scientific journal)

FEASIBILITY OF ESTIMATING THE NOVEL QUANTITATIVE STRUCTURE ACTIVITY RELATIONSHIP (QSAR) DESCRIPTOR-SIGMA-S0 BY MEANS OF GAS-LIQUID-CHROMATOGRAPHY .1. HALOGENOBENZENE DERIVATIVES

Y SASAKI, S FUJII, T TAKAGI, H KAWAKI

CHEMICAL & PHARMACEUTICAL BULLETIN　Vol. 37　No. 6　p. 1554-1555　1989/06　Research paper (scientific journal)

FACTOR-ANALYSIS OF THE SOLUTE STATIONARY PHASE INTERACTIONS IN GAS-LIQUID-CHROMATOGRAPHY USING THE OBLIQUE PROCRASTES TRANSFORMATION

T TAKAGI, Y SHINDO, H FUJIWARA, Y SASAKI

CHEMICAL & PHARMACEUTICAL BULLETIN　Vol. 37　No. 6　p. 1556-1560　1989/06　Research paper (scientific journal)

ON THE NOVEL QUANTITATIVE STRUCTURE ACTIVITY RELATIONSHIPS (QSAR) DESCRIPTORS SIGMA-S-DEGREES AND MU-2-ALPHA DEDUCED FROM THE MODIFIED LENNARD-JONES 12,6 POTENTIALS

Y SASAKI, T TAKAGI, H KAWAKI

CHEMICAL & PHARMACEUTICAL BULLETIN　Vol. 36　No. 10　p. 3743-3752　1988/10　Research paper (scientific journal)

THE SOLVATION EFFECT ON THE REACTIONS IN SOLUTION .3. THE ENTROPY OF SOLUTION OF ALKANES MEASURED BY GAS-LIQUID-CHROMATOGRAPHY AND INTERPRETED BY MEANS OF SCALED PARTICLE THEORY

H FUJIWARA, OHTAKU, I, T TAKAGI, S MURATA, Y SASAKI

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN　Vol. 61　No. 6　p. 1853-1856　1988/06　Research paper (scientific journal)

NMR-STUDY OF MOLECULES IN ANISOTROPIC SYSTEMS .6. SOLUTION STRUCTURE AND PREFERRED ORIENTATION OF 3,7-DIBROMO-10H-PHENOTHIAZINE DISSOLVED IN NEMATIC LIQUID-CRYSTAL

H FUJIWARA, M WATANABE, YAMANAKA, I, T TAKAGI, Y SASAKI

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN　Vol. 61　No. 2　p. 369-373　1988/02　Research paper (scientific journal)

DEVELOPMENT AND APPLICATIONS FOR THE SIMULATOR OF INTERMOLECULAR POTENTIALS .2. HYDRATION EFFECTS ON THE CONFORMATION OF TYRAMINE

T TAKAGI, A TANAKA, M TANI, H MAEZAKI, H FUJIWARA, Y SASAKI

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN　Vol. 61　No. 2　p. 329-332　1988/02　Research paper (scientific journal)

COMPUTATIONAL STUDIES ON CH PI-INTERACTIONS

T TAKAGI, A TANAKA, S MATSUO, H MAEZAKI, M TANI, H FUJIWARA, Y SASAKI

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2　No. 8　p. 1015-1018　1987/08　Research paper (scientific journal)

Computational Studies on CH/π Interactions.

Tatsuya Takagi, Akito Tanaka, Sanshiro Matsuo, Hironobu Maezaki, Mika Tani, Hideaki Fujiwara, Yoshio Sasaki

Journal of the Chemical Society Perkin Transactions. 2　No. 8　p. 1015-1018　1987　Research paper (scientific journal)

A NOVEL DEVELOPMENT FOR THE SIMULATOR OF INTERMOLECULAR POTENTIALS

T TAKAGI, A TANAKA, S MAEDA, S MATSUO, H FUJIWARA, Y SASAKI

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN　Vol. 59　No. 5　p. 1317-1320　1986/05　Research paper (scientific journal)

NMR-STUDY OF MOLECULES IN ANISOTROPIC SYSTEMS .3. STRUCTURE AND ORIENTATION OF 1A,2A,3E,4E,5E,6A-HEXACHLOROCYCLOHEXANE IN A NEMATIC LIQUID-CRYSTAL DETERMINED FROM LOW-TEMPERATURE EXPERIMENTS

H FUJIWARA, N SHIMIZU, T TAKAGI, Y SASAKI

MAGNETIC RESONANCE IN CHEMISTRY　Vol. 24　No. 1　p. 71-74　1986/01　Research paper (scientific journal)

NMR-STUDY OF MOLECULES IN ANISOTROPIC SYSTEMS - THE MULTIPLE-QUANTUM CTEF SPECTRA OF 1E,2A,3A,4A,5A,6A-HEXACHLOROCYCLOHEXANE IN EBBA

H FUJIWARA, N SHIMIZU, T TAKAGI, Y SASAKI, K TAKAHASHI

JOURNAL OF MAGNETIC RESONANCE　Vol. 64　No. 2　p. 325-329　1985　Research paper (scientific journal)

NMR study of molecules in anisotropic systems. The multiple-quantum CTEF spectra of 1e,2a,3a,4a,5a,6ahexachlorocyclohexane in EBBA

Hideaki Fujiwara, Naoto Shimizu, Tatsuya Takagi, Yoshio Sasaki, Kensuke Takahashi

Journal of Magnetic Resonance (1969)　Vol. 64　No. 2　p. 325-329　1985　Research paper (scientific journal)

NMR-STUDY OF MOLECULES IN ANISOTROPIC SYSTEMS .2. 1A,2A,3E,4E,5E,6E-HEXACHLOROCYCLOHEXANES AND 1E,2E,3E,4E,5E,6E-HEXACHLOROCYCLOHEXANES DISSOLVED IN NEMATIC LIQUID-CRYSTALS

H FUJIWARA, N SHIMIZU, T TAKAGI, Y SASAKI

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN　Vol. 58　No. 8　p. 2285-2288　1985　Research paper (scientific journal)

STUDIES ON THE SPECIFIC RETENTION RATIO IN GAS-LIQUID CHROMATOGRAPHY OF ACYCLIC SATURATED-HYDROCARBONS BY MEANS OF LENNARD-JONES (12,6) POTENTIAL FORCE-CONSTANTS

Y SASAKI, T TAKAGI, SL HSIU, K NAKAMURA

CHEMICAL & PHARMACEUTICAL BULLETIN　Vol. 33　No. 8　p. 3385-3389　1985　Research paper (scientific journal)

THE GASEOUS STANDARD ENTROPY S298-DEGREES-(G) OF THE 3RD LAW OF THERMODYNAMICS CAN BE ESTIMATED FROM GAS-CHROMATOGRAPHIC RETENTION DATA

Y SASAKI, H FUJIWARA, T TAKAGI, A IWATA, SL HSIU

CHEMICAL & PHARMACEUTICAL BULLETIN　Vol. 32　No. 3　p. 1239-1241　1984

ASSOCIATION BETWEEN POLAR-MOLECULES .3. H-1 AND C-13 NMR-STUDIES ON THE DIPOLE ASSOCIATION OF ACETONITRILE DERIVATIVES WITH TETRAMETHYLUREA AND DIBUTYL SULFOXIDE IN NONPOLAR-SOLVENTS

T TAKAGI, H FUJIWARA, Y SASAKI

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN　Vol. 57　No. 5　p. 1299-1303　1984　Research paper (scientific journal)

Non-linear least squares program for the analysis of <sup>13</sup>C spin-lattice relaxation data based on a symmetric top model. Description of the method and application

Hideaki Fujiwara, Tatsuya Takagi, Makiko Sugiura, Yoshio Sasaki

Journal of the Chemical Society, Perkin Transactions 2　No. 7　p. 903-906　1983　Research paper (scientific journal)

QSAR ANALYSIS BY MEANS OF NOVEL SUBSTITUENT ENTROPY CONSTANT SIGMA-S0

Y SASAKI, T TAKAGI, A IWATA, H KAWAKI

JOURNAL OF PHARMACOBIO-DYNAMICS　Vol. 6　No. 5　p. S101-S101　1983

STUDIES ON QUANTITATIVE STRUCTURE ACTIVITY RELATIONSHIPS .5. QSAR INVESTIGATIONS OF RIFAMYCIN-B AMIDES AND HYDRAZIDES BY UTILIZATION OF THE SUBSTITUENT ENTROPY CONSTANT-SIGMA-S-0

H KAWAKI, T TAKAGI, Y SASAKI

CHEMICAL & PHARMACEUTICAL BULLETIN　Vol. 31　No. 1　p. 144-148　1983　Research paper (scientific journal)

NON-LINEAR LEAST-SQUARES PROGRAM FOR THE ANALYSIS OF C-13 SPIN-LATTICE RELAXATION DATA BASED ON A SYMMETRIC TOP MODEL - DESCRIPTION OF THE METHOD AND APPLICATION

H FUJIWARA, T TAKAGI, M SUGIURA, Y SASAKI

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2　No. 7　p. 903-906　1983　Research paper (scientific journal)

SOLUTION STRUCTURE OF THIANTHRENE - DIHEDRAL ANGLE BETWEEN THE BENZENE RINGS DETERMINED FROM THE ANALYSIS OF NMR-SPECTRA IN NEMATIC PHASE

H FUJIWARA, A KAWAMURA, T TAKAGI, Y SASAKI

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY　Vol. 105　No. 1　p. 125-126　1983

NOVEL SUBSTITUENT ENTROPY CONSTANT-SIGMA-S0 REPRESENTS THE MOLECULAR CONNECTIVITY-X AND IT RELATED INDEXES

Y SASAKI, T TAKAGI, H KAWAKI, A IWATA

CHEMICAL & PHARMACEUTICAL BULLETIN　Vol. 31　No. 1　p. 330-332　1983

THE SUBSTITUENT ENTROPY CONSTANT SIGMA-S-DEGREES USED IN THE QSAR INVESTIGATION OF DIHYDROFOLATE-REDUCTASE INHIBITION BY BAKER TRIAZINES

H KAWAKI, T TAKAGI, A IWATA, Y SASAKI

CHEMICAL & PHARMACEUTICAL BULLETIN　Vol. 30　No. 2　p. 750-751　1982

STUDIES ON QUANTITATIVE STRUCTURE-ACTIVITY-RELATIONSHIPS .4. USEFULNESS OF THE NOVEL SUBSTITUENT ENTROPY CONSTANT SIGMA-S-DEGREE AND THE SIGN OF THE ENTHALPY PARAMETER

Y SASAKI, T TAKAGI, A IWATA, H KAWAKI

CHEMICAL & PHARMACEUTICAL BULLETIN　Vol. 30　No. 9　p. 3069-3073　1982

SOLVATION EFFECT ON THE COMPLEX-FORMATION BETWEEN ORTHO-QUINONES AND METAL CHLORIDES IN NON-AQUEOUS MEDIA

K KATAOKA, T TAKAGI, Y SASAKI

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN　Vol. 55　No. 5　p. 1344-1347　1982　Research paper (scientific journal)

ASSOCIATION BETWEEN POLAR-MOLECULES .2. EQUILIBRIUM AND THERMODYNAMIC STUDIES ON THE DIPOLE ASSOCIATION OF BENZONITRILE DERIVATIVES WITH HEXAMETHYLPHOSPHORAMIDE, DI-NORMAL-BUTYL SULFONE, DI-NORMAL-BUTYL SULFOXIDE AND TETRAMETHYLUREA IN NONPOLAR-SOLVENTS

H FUJIWARA, T TAKAGI, Y YAMAZAKI, Y SASAKI

JOURNAL OF THE CHEMICAL SOCIETY-FARADAY TRANSACTIONS I　Vol. 78　No. 2　p. 347-356　1982　Research paper (scientific journal)

CHARACTERIZATION OF NOVEL SUBSTITUENT ENTROPY CONSTANT BY CLUSTER-ANALYSIS

T TAKAGI, A IWATA, Y SASAKI, H KAWAKI

CHEMICAL & PHARMACEUTICAL BULLETIN　Vol. 30　No. 3　p. 1091-1093　1982

UTILITY OF THE SUBSTITUENT ENTROPY CONSTANTS SIGMA-S-0 IN THE STUDIES OF QUANTITATIVE STRUCTURE-ACTIVITY-RELATIONSHIPS

Y SASAKI, T TAKAGI, Y YAMAZATO, A IWATA, H KAWAKI

CHEMICAL & PHARMACEUTICAL BULLETIN　Vol. 29　No. 10　p. 3073-3075　1981

NUCLEAR MAGNETIC-RESONANCE STUDIES OF ACID-BASE ASSOCIATION IN SOLUTION .2. ASSOCIATION BETWEEN KETONES AND TRIS(DIPIVALOYLMETHANATO)EUROPIUM

H KAWAKI, T TAKAGI, H FUJIWARA, Y SASAKI

CHEMICAL & PHARMACEUTICAL BULLETIN　Vol. 29　No. 9　p. 2397-2402　1981　Research paper (scientific journal)