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Kawahara Yukio
河原　行郎
Kawahara Yukio
河原　行郎
Graduate School of Medicine　Division of Medicine, Professor

keyword Z-RNA，RNA editing/modifications，RNA biology，amyotrophic lateral sclerosis (ALS)，neurodegenerative diseases

Research History 13

  1. 2025/04 - Present
    The University of Osaka　Vice President

  2. 2014/04 - Present
    Graduate School of Medicine, Osaka University　Department of RNA Biology and Neuroscience　Professor

  3. 2025/04 - 2030/03
    学術変革領域研究(A)　「攪乱RNA学創成」領域　領域代表者

  4. 2019/08 - 2025/03
    Osaka University

  5. 2019/04 - 2021/03
    大阪大学大学院医学系研究科　副研究科長

  6. 2019/04 - 2019/08
    Osaka University

  7. 2017/04 - 2019/03
    The University of Osaka Graduate School of Medicine

  8. 2013/04 - 2014/03
    Graduate School of Medicine, Osaka University　Laboratory of RNA function　Associate Professor

  9. 2008/12 - 2013/03
    Graduate School of Medicine, Osaka University　Laboratory of RNA function　Associate Proessor (tenura-track)

  10. 2004/06 - 2008/11
    The Wistar Institute　Department of Gene Expression and Regulation　Postdoctoral fellow

  11. 2004/04 - 2004/05
    The University of Tokyo Hospital　Department of Neurology　JSPS postdoctoral fellow

  12. 1907/06 - 2000/03
    東京大学医学部附属病院およびその関連病院　神経内科　臨床医

  13. 1995/06 - 1997/05
    The University of Tokyo Hospital and its related hospitals　Clinician

Education 2

  1. Graduate School of Medicine, The University of Tokyo　PhD student

    2000/04 - 2004/03

  2. The University of Tokyo　Department of Medicine

    1989/04 - 1995/03

Professional Memberships 8

  1. The RNA Society

  2. The American Association of Immunologists

  3. THE JAPANESE SOCIETY OF INTERNAL MEDICINE

  4. THE JAPANESE SOCIETY FOR IMMUNOLOGY

  5. THE RNA SOCIETY OF JAPAN

  6. THE MOLECULAR BIOLOGY SOCIETY OF JAPAN

  7. THE JAPAN NEUROSCIENCE SOCIETY

  8. JAPANESE SOCIETY OF NEUROLOGY

Research Areas 2

  1. Life sciences / Molecular biology / RNA biology

  2. Life sciences / Pathobiochemistry / neurodegenerative diseases

Awards 2

  1. 日本医師会医学研究奨励賞

    日本医師会　2014/11

  2. Ching Jer Chern Memorial Award 2008

    The Wistar Institute　2008/06

Papers 53

  1. Synaptotagmin 4 supports spontaneous axon sprouting after spinal cord injury

    Kyoka Higuchi, Akiko Uyeda, Lili Quan, Shogo Tanabe, Yuki Kato, Yukio Kawahara, Rieko Muramatsu

    The Journal of Neuroscience　2024/09/12　Research paper (scientific journal)

    Publisher: Society for Neuroscience

  2. A cancer-associated METTL14 mutation induces aberrant m6A modification, affecting tumor growth

    Kotaro Miyake, Pedro Henrique Costa Cruz, Izumi Nagatomo, Yuki Kato, Daisuke Motooka, Shingo Satoh, Yuichi Adachi, Yoshito Takeda, Yukio Kawahara, Atsushi Kumanogoh

    Cell Reports　Vol. 42　No. 7　p. 112688-112688　2023/06　Research paper (scientific journal)

    Publisher: Elsevier BV

  3. RNA editing of AZIN1 coding sites is catalyzed by ADAR1 p150 after splicing

    Yanfang Xing, Taisuke Nakahama, Yuke Wu, Maal Inoue, Jung In Kim, Hiroyuki Todo, Toshiharu Shibuya, Yuki Kato, Yukio Kawahara

    Journal of Biological Chemistry　Vol. 299　No. 7　p. 104840-104840　2023/05　Research paper (scientific journal)

    Publisher: Elsevier BV

  4. The RNA-editing enzyme ADAR1: a regulatory hub that tunes multiple dsRNA-sensing pathways

    Taisuke Nakahama, Yukio Kawahara

    International Immunology　Vol. 35　No. 3　p. 123-133　2022/12/05　Research paper (scientific journal)

    Publisher: Oxford University Press (OUP)

  5. The N6-methyladenosine methyltransferase METTL16 enables erythropoiesis through safeguarding genome integrity

    Masanori Yoshinaga, Kyuho Han, David W. Morgens, Takuro Horii, Ryosuke Kobayashi, Tatsuaki Tsuruyama, Fabian Hia, Shota Yasukura, Asako Kajiya, Ting Cai, Pedro H. C. Cruz, Alexis Vandenbon, Yutaka Suzuki, Yukio Kawahara, Izuho Hatada, Michael C. Bassik, Osamu Takeuchi

    Nature Communications　Vol. 13　No. 1　p. 6435-6435　2022/10/28　Research paper (scientific journal)

    Publisher: Springer Science and Business Media LLC

  6. Alignment of single-cell trajectory trees with CAPITAL

    Reiichi Sugihara, Yuki Kato, Tomoya Mori, Yukio Kawahara

    Nature Communications　Vol. 13　No. 1　2022/10/14　Research paper (scientific journal)

    Publisher: Springer Science and Business Media LLC

  7. An Aicardi-Goutières Syndrome–Causative Point Mutation in Adar1 Gene Invokes Multiorgan Inflammation and Late-Onset Encephalopathy in Mice

    Maal Inoue, Taisuke Nakahama, Ryuichiro Yamasaki, Toshiharu Shibuya, Jung In Kim, Hiroyuki Todo, Yanfang Xing, Yuki Kato, Eiichi Morii, Yukio Kawahara

    The Journal of Immunology　Vol. 207　No. 12　p. 3016-3027　2021/11/12　Research paper (scientific journal)

    Publisher: The American Association of Immunologists

  8. Deciphering the Biological Significance of ADAR1–Z-RNA Interactions

    Taisuke Nakahama, Yukio Kawahara

    International Journal of Molecular Sciences　Vol. 22　No. 21　2021/10　Research paper (scientific journal)

  9. Mutations in the adenosine deaminase ADAR1 that prevent endogenous Z-RNA binding induce Aicardi-Goutières-syndrome-like encephalopathy

    Taisuke Nakahama, Yuki Kato, Toshiharu Shibuya, Maal Inoue, Jung In Kim, Tuangtong Vongpipatana, Hiroyuki Todo, Yanfang Xing, Yukio Kawahara

    Immunity　Vol. 54　No. 9　p. 1976-1988.e7　2021/09　Research paper (scientific journal)

    Publisher: Elsevier BV

  10. Dimethylarginine dimethylaminohydrolase 1 as a novel regulator of oligodendrocyte differentiation in the central nervous system remyelination

    Akiko Uyeda, Lili Quan, Yuki Kato, Nagaaki Muramatsu, Shogo Tanabe, Kazuhisa Sakai, Noritaka Ichinohe, Yukio Kawahara, Tatsunori Suzuki, Rieko Muramatsu

    Glia　Vol. 69　No. 11　p. 2591-2604　2021/07/16　Research paper (scientific journal)

    Publisher: Wiley

  11. RNA editing at a limited number of sites is sufficient to prevent MDA5 activation in the mouse brain

    Jung In Kim, Taisuke Nakahama, Ryuichiro Yamasaki, Pedro Henrique Costa Cruz, Tuangtong Vongpipatana, Maal Inoue, Nao Kanou, Yanfang Xing, Hiroyuki Todo, Toshiharu Shibuya, Yuki Kato, Yukio Kawahara

    PLOS Genetics　Vol. 17　No. 5　p. e1009516-e1009516　2021/05/13　Research paper (scientific journal)

    Publisher: Public Library of Science (PLoS)

  12. Age-dependent decline in remyelination capacity is mediated by apelin–APJ signaling

    Masumi Ito, Rieko Muramatsu, Yuki Kato, Bikram Sharma, Akiko Uyeda, Shogo Tanabe, Harutoshi Fujimura, Hiroyasu Kidoya, Nobuyuki Takakura, Yukio Kawahara, Masaki Takao, Hideki Mochizuki, Akiyoshi Fukamizu, Toshihide Yamashita

    Nature Aging　Vol. 1　No. 3　p. 284-294　2021/03　Research paper (scientific journal)

    Publisher: Springer Science and Business Media LLC

  13. RNA Editing in Neurological and Neurodegenerative Disorders

    Pedro Henrique Costa Cruz, Yukio Kawahara

    Methods in Molecular Biology　Vol. 2181　p. 309-330　2021　Part of collection (book)

    Publisher: Springer US

  14. ADAR1 Regulates Early T Cell Development via MDA5-Dependent and -Independent Pathways.

    Vongpipatana T, Nakahama T, Shibuya T, Kato Y, Kawahara Y

    The Journal of Immunology　Vol. 204　No. 8　p. 2156-2168　2020/03/13　Research paper (scientific journal)

  15. Adenosine-to-inosine RNA editing in the immune system: friend or foe?

    Taisuke Nakahama, Yukio Kawahara

    Cellular and Molecular Life Sciences　Vol. 77　No. 15　p. 2931-2948　2020/01/29　Research paper (scientific journal)

    Publisher: Springer Science and Business Media LLC

  16. Bivartect: accurate and memory-saving breakpoint detection by direct read comparison

    Keisuke Shimmura, Yuki Kato, Yukio Kawahara

    Bioinformatics　Vol. 36　No. 9　p. 2725-2730　2020/01/27　Research paper (scientific journal)

    Publisher: Oxford University Press (OUP)

  17. A comparative analysis of ADAR mutant mice reveals site-specific regulation of RNA editing

    Pedro Henrique Costa Cruz, Yuki Kato, Taisuke Nakahama, Toshiharu Shibuya, Yukio Kawahara

    RNA　Vol. 26　No. 4　p. 454-469　2020/01/15　Research paper (scientific journal)

    Publisher: Cold Spring Harbor Laboratory

  18. ADAR1-mediated RNA editing is required for thymic self-tolerance and inhibition of autoimmunity.

    Taisuke Nakahama, Yuki Kato, Jung In Kim, Tuangtong Vongpipatana, Yutaka Suzuki, Carl R Walkley, Yukio Kawahara

    EMBO reports　Vol. 19　No. 12　2018/12　Research paper (scientific journal)

  19. Quantification of methylation efficiency at a specific N6-methyladenosine position in rRNA by using BNA probes.

    Oshima T, Ishiguro K, Suzuki T, Kawahara Y

    Chemical Communications (Camb)　Vol. 54　No. 69　p. 9627-9630　2018/08　Research paper (scientific journal)

  20. Myotube-derived factor promotes oligodendrocyte precursor cell proliferation

    Akino Nakasone, Rieko Muramatsu, Yuki Kato, Yukio Kawahara, Toshihide Yamashita

    Biochemical and Biophysical Research Communications　Vol. 500　No. 3　p. 609-613　2018/06/07　Research paper (scientific journal)

    Publisher: Elsevier B.V.

  21. RNA editing independently occurs at three mir-376a-1 sites and may compromise the stability of the microRNA hairpin

    Alicia Gallego, Diego A. Hartasanchez, Marina Braso-Vives, Eva Garcia-Ramallo, Maria Lopez-Valenzuela, Neus Baena, Miriam Guitart, Hugo Fernandez-Bellon, Ivanela Kondova, Ronald Bontrop, Yukio Kawahara, Yolanda Espinosa-Parrilla

    GENE　Vol. 628　p. 109-116　2017/09　Research paper (scientific journal)

  22. Matrin3 binds directly to intronic pyrimidine-rich sequences and controls alternative splicing

    Yuri Uemura, Takuya Oshima, Munetaka Yamamoto, Charles Jourdan Reyes, Pedro Henrique Costa Cruz, Toshiharu Shibuya, Yukio Kawahara

    GENES TO CELLS　Vol. 22　No. 9　p. 785-798　2017/09　Research paper (scientific journal)

  23. The RNA-binding protein MARF1 promotes cortical neurogenesis through its RNase activity domain

    Yoshitaka Kanemitsu, Masashi Fujitani, Yuki Fujita, Suxiang Zhang, You-Qiang Su, Yukio Kawahara, Toshihide Yamashita

    SCIENTIFIC REPORTS　Vol. 7　No. 1　2017/04　Research paper (scientific journal)

  24. CAPS1 RNA Editing Promotes Dense Core Vesicle Exocytosis

    Kotaro Miyake, Toshio Ohta, Hisako Nakayama, Nobutaka Doe, Yuri Terao, Eiji Oiki, Izumi Nagatomo, Yui Yamashita, Takaya Abe, Kazuko Nishikura, Atsushi Kumanogoh, Kouichi Hashimoto, Yukio Kawahara

    CELL REPORTS　Vol. 17　No. 8　p. 2004-2014　2016/11　Research paper (scientific journal)

  25. Cross-Linking and Immunopresipitation of Nuclear RNA-Binding Proteins.

    Li, Q, Uemura, Y, Kawahara, Y

    Methods in Molecular Biology　Vol. 1262　p. 247-263　2015/01　Research paper (scientific journal)

    Publisher: Springer社

  26. The cleavage pattern of TDP-43 determines its rate of clearance and cytotoxicity

    Quan Li, Moe Yokoshi, Hitomi Okada, Yukio Kawahara

    Nature Communications　Vol. 6　2015/01　Research paper (scientific journal)

  27. Direct Binding of Ataxin-2 to Distinct Elements in 3 ' UTRs Promotes mRNA Stability and Protein Expression

    Moe Yokoshi, Quan Li, Munetaka Yamamoto, Hitomi Okada, Yutaka Suzuki, Yukio Kawahara

    MOLECULAR CELL　Vol. 55　No. 2　p. 186-198　2014/07　Research paper (scientific journal)

  28. Human diseases caused by germline and somatic abnormalities in microRNA and microRNA-related genes

    Yukio Kawahara

    CONGENITAL ANOMALIES　Vol. 54　No. 1　p. 12-21　2014/02　Research paper (scientific journal)

  29. Aryl hydrocarbon receptor-mediated induction of the microRNA-132/212 cluster promotes interleukin-17-producing T-helper cell differentiation

    Taisuke Nakahama, Hamza Hanieh, Nam Trung Nguyen, Ichino Chinen, Barry Ripley, David Millrine, Soyoung Lee, Kishan Kumar Nyati, Praveen Kumar Dubey, Kamal Chowdhury, Yukio Kawahara, Tadamitsu Kishimoto

    Proceedings of the National Academy of Sciences of the United States of America　Vol. 110　No. 29　p. 11964-11969　2013/07/16　Research paper (scientific journal)

  30. Circulating p53-responsive MicroRNAs are predictive indicators of heart failure after acute myocardial infarction

    Matsumoto, S., Sakata, Y., Suna, S., Nakatani, D., Usami, M., Hara, M., Kitamura, T., Hamasaki, T., Nanto, S., Kawahara, Y., Komuro, I.

    Circulation Research　Vol. 113　No. 3　p. 322-326　2013　Research paper (scientific journal)

  31. Tissue- and plasma-specific MicroRNA signatures for atherosclerotic abdominal aortic aneurysm.

    Keiwa Kin, Shigeru Miyagawa, Satsuki Fukushima, Yukitoshi Shirakawa, Kei Torikai, Kazuo Shimamura, Takashi Daimon, Yukio Kawahara, Toru Kuratani, Yoshiki Sawa

    Journal of the American Heart Association　Vol. 1　No. 5　2012/10　Research paper (scientific journal)

  32. A subset of circulating microRNAs are predictive for cardiac death after discharge for acute myocardial infarction

    Sen Matsumoto, Yasuhiko Sakata, Daisaku Nakatani, Shinichiro Suna, Hiroya Mizuno, Masahiko Shimizu, Masaya Usami, Tatsuya Sasaki, Hiroshi Sato, Yukio Kawahara, Toshimitsu Hamasaki, Shinsuke Nanto, Masatsugu Hori, Issei Komuro

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 427　No. 2　p. 280-284　2012/10　Research paper (scientific journal)

  33. Quantification of adenosine-to-inosine editing of microRNAs using a conventional method

    Yukio Kawahara

    NATURE PROTOCOLS　Vol. 7　No. 7　p. 1426-1437　2012/07　Research paper (scientific journal)

  34. TDP-43 promotes microRNA biogenesis as a component of the Drosha and Dicer complexes

    Yukio Kawahara, Ai Mieda-Sato

    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　Vol. 109　No. 9　p. 3347-3352　2012/02　Research paper (scientific journal)

  35. Functional relevance of serotonin 2C receptor mRNA editing in antidepressant- and anxiety-like behaviors

    Cedric Mombereau, Yukio Kawahara, Brigitta B. Gundersen, Kazuko Nishikura, Julie A. Blendy

    NEUROPHARMACOLOGY　Vol. 59　No. 6　p. 468-473　2010/11　Research paper (scientific journal)

  36. Dysregulated Editing of Serotonin 2C Receptor mRNAs Results in Energy Dissipation and Loss of Fat Mass

    Yukio Kawahara, Adda Grimberg, Sarah Teegarden, Cedric Mombereau, Sui Liu, Tracy L. Bale, Julie A. Blendy, Kazuko Nishikura

    JOURNAL OF NEUROSCIENCE　Vol. 28　No. 48　p. 12834-12844　2008/11　Research paper (scientific journal)

  37. Frequency and fate of microRNA editing in human brain

    Yukio Kawahara, Molly Megraw, Edward Kreider, Hisashi Iizasa, Louis Valente, Artemis G. Hatzigeorgiou, Kazuko Nishikura

    NUCLEIC ACIDS RESEARCH　Vol. 36　No. 16　p. 5270-5280　2008/09　Research paper (scientific journal)

  38. RNA editing of the microRNA-151 precursor blocks cleavage by the Dicer-TRBP complex

    Yukio Kawahara, Boris Zinshteyn, Thimmaiah P. Chendrimada, Ramin Shiekhattar, Kazuko Nishikura

    EMBO REPORTS　Vol. 8　No. 8　p. 763-769　2007/08　Research paper (scientific journal)

  39. Redirection of silencing targets by adenosine-to-inosine editing of miRNAs

    Yukio Kawahara, Boris Zinshteyn, Praveen Sethupathy, Hisashi Iizasa, Artemis G. Hatzigeorgiou, Kazuko Nishikura

    SCIENCE　Vol. 315　No. 5815　p. 1137-1140　2007/02　Research paper (scientific journal)

  40. Slow and selective death of spinal motor neurons in vivo by intrathecal infusion of kainic acid: implications for AMPA receptor-mediated excitotoxicity in ALS

    Hui Sun, Yukio Kawahara, Kyoko Ito, Ichiro Kanazawa, Shin Kwak

    JOURNAL OF NEUROCHEMISTRY　Vol. 98　No. 3　p. 782-791　2006/08　Research paper (scientific journal)

  41. Extensive adenosine-to-inosine editing detected in Alu repeats of antisense RNAs reveals scarcity of sense-antisense duplex formation

    Y Kawahara, K Nishikura

    FEBS LETTERS　Vol. 580　No. 9　p. 2301-2305　2006/04　Research paper (scientific journal)

  42. A-to-I RNA Editing and Human Disease

    Maas S, Kawahara Y, Tamburro KM, Nishikura K

    RNA Biol　Vol. 3　p. e1-e9　2006　Research paper (scientific journal)

  43. Underediting of GluR2 mRNA, a neuronal death inducing molecular change in sporadic ALS, does not occur in motor neurons in ALS1 or SBMA

    Y Kawahara, H Sun, K Ito, T Hideyama, M Aoki, G Sobue, S Tsuji, S Kwak

    NEUROSCIENCE RESEARCH　Vol. 54　No. 1　p. 11-14　2006/01　Research paper (scientific journal)

  44. Novel splice variants of human ADAR2 mRNA: Skipping of the exon encoding the dsRNA-binding domains, and multiple C-terminal splice sites

    Y Kawahara, K Ito, M Ito, S Tsuji, S Kwak

    GENE　Vol. 363　p. 193-201　2005/12　Research paper (scientific journal)

  45. Excitotoxicity and ALS: What is unique about the AMPA receptors expressed on spinal motor neurons?

    Y Kawahara, S Kwak

    AMYOTROPHIC LATERAL SCLEROSIS AND OTHER MOTOR NEURON DISORDERS　Vol. 6　No. 3　p. 131-144　2005/09　Research paper (scientific journal)

  46. Expression profile of AMPA receptor subunit mRNA in single adult rat brain and spinal cord neurons in situ

    H Sun, Y Kawahara, K Ito, Kanazawa, I, S Kwak

    NEUROSCIENCE RESEARCH　Vol. 52　No. 3　p. 228-234　2005/07　Research paper (scientific journal)

  47. Deficient RNA editing of GluR2 and neuronal death in amyotropic lateral sclerosis

    S Kwak, Y Kawahara

    JOURNAL OF MOLECULAR MEDICINE-JMM　Vol. 83　No. 2　p. 110-120　2005/02　Research paper (scientific journal)

  48. GluR4c, an alternative splicing isoform of GluR4, expressed in the adult human brain* is abundantly

    Y Kawahara, K Ito, H Sun, M Ito, Kanazawa, I, S Kwak

    MOLECULAR BRAIN RESEARCH　Vol. 127　No. 1-2　p. 150-155　2004/08　Research paper (scientific journal)

  49. Glutamate receptors: RNA editing and death of motor neurons

    Y Kawahara, K Ito, H Sun, H Aizawa, Kanazawa, I, S Kwak

    NATURE　Vol. 427　No. 6977　p. 801-801　2004/02　Research paper (scientific journal)

  50. Regulation of glutamate receptor RNA editing and ADAR mRNA expression in developing human normal and Down's syndrome brains

    Y Kawahara, K Ito, H Sun, M Ito, Kanazawa, I, S Kwak

    DEVELOPMENTAL BRAIN RESEARCH　Vol. 148　No. 1　p. 151-155　2004/01　Research paper (scientific journal)

  51. Low editing efficiency of GluR2 mRNA is associated with a low relative abundance of ADAR2 mRNA in white matter of normal human brain

    Y Kawahara, K Ito, H Sun, Kanazawa, I, S Kwak

    EUROPEAN JOURNAL OF NEUROSCIENCE　Vol. 18　No. 1　p. 23-33　2003/07　Research paper (scientific journal)

  52. Human spinal motoneurons express low relative abundance of GluR2 mRNA: an implication for excitotoxicity in ALS

    Y Kawahara, S Kwak, H Sun, K Ito, H Hashida, H Aizawa, SY Jeong, Kanazawa, I

    JOURNAL OF NEUROCHEMISTRY　Vol. 85　No. 3　p. 680-689　2003/05　Research paper (scientific journal)

  53. Motor cortical reflex myoclonus: a case study with MEG

    Yasuo Terao, Yoshikazu Ugawa, Ritsuko Hanajima, Masato Yumoto, Yukio Kawahara, Tomotaka Yamamoto, Ichiro Shirouzu, Ichiro Kanazawa

    Electroencephalography and Clinical Neurophysiology　Vol. 102　No. 6　p. 505-511　1997/06　Research paper (scientific journal)

    Publisher: Elsevier BV

Misc. 50

  1. N/A

    Clinical Neuroscience　Vol. 41　No. 5　p. 684-686　2023/05

  2. The roles of RNA editing in viral infection.

    中濱泰祐, 河原行郎

    月刊臨床免疫・アレルギー科　Vol. 80　No. 4　2023

  3. Type I interferonopathies caused by dysregulation of RNA metabolism

    Taisuke Nakahama, Yukio Kawahara

    Vol. 40　No. 15　p. 2505-2512　2022/09

  4. RNA editing: its physiological functions and application to gene modification technology

    Yukio Kawahara

    Vol. 40　No. 12　p. 1952-1958　2022/07　Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)

  5. Left-handed RNA as a novel molecular pattern recognized by innate immune system

    Yukio Kawahara

    Clinical Immunology & Allergology　Vol. 78　No. 1　p. 111-117　2022/07　Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)

  6. Reduced RNA editing activity of ADAR1 p150 induces Aicardi-Goutières syndrome-like symptoms in mice

    Taisuke Nakahama, Yukio Kawahara

    Clinical Immunology & Allergology　Vol. 77　No. 6　p. 737-743　2022/06　Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)

  7. RNAの巻き方を感知する自己免疫システム

    中濱泰祐, 河原行郎

    実験医学　Vol. 40　No. 4　p. 544-549　2022/03　Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)

  8. RNA編集を応用した核酸医薬開発の展望

    河原 行郎

    実験医学増刊号　Vol. 39　No. 17　p. 2772-2778　2021/10

  9. epitranscriptome

    Yukio Kawahara

    Vol. 28　No. 6　p. 546-550　2020/11　Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)

  10. CLIP法とその改良法によるタンパク質結合RNAの高解像度解析

    河原行郎

    実験医学(別冊)　p. 149-158　2016

  11. RNA代謝異常を介した神経変性疾患の発症病態

    余越萌, 河原行郎

    ファルマシア　Vol. 51　No. 1　p. 37-41　2015

  12. 神経変性疾患の発症メカニズムUp-to-Date

    河原行郎

    BIO Clinica　Vol. 30　No. 7　p. 705-708　2015

  13. マイクロRNA

    余越萌, 河原行郎

    生体の科学　Vol. 66　No. 5　p. 478-479　2015

  14. 神経疾患をmicroRNAで診断する

    河原行郎

    Clinical Neuroscience　Vol. 33　No. 11　p. 1302-1304　2015

  15. 自己免疫疾患とRNA編集

    三宅浩太郎, 中濱泰祐, 河原行郎

    実験医学(増刊)　Vol. 33　No. 20　p. 3339-3344　2015

  16. 神経変性疾患関連タンパク質Ataxin-2は3’非翻訳領域にある特定の配列に直接結合することによって、mRNAの安定性を促進しタンパク質発現を増加させる

    余越 萌, 河原行郎

    ライフサイエンス新着論文レビュー　2014/07　Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)

  17. RNA疾患研究の新展開

    河原行郎, 塩見美喜子

    Medical Science Digest 臨時増刊号 RNA疾患 (河原行郎・塩見美喜子編輯)　Vol. 40　No. 7　p. 324-325　2014

  18. RNA代謝と神経変性

    植村有里, 河原行郎

    Brain Medical　Vol. 26　No. 3　p. 209-215　2014

  19. 神経変性疾患に関連するタンパク質Ataxin-2は3’側非翻訳領域に直接に結合することによりmRNAの安定性を促進する

    余越 萌, 河原行郎

    新着論文レビュー　p. e9044-e9044　2014

  20. Response to the letter by devaux et al

    Yasuhiko Sakata, Sen Matsumoto, Toshimitsu Hamasaki, Yukio Kawahara, Issei Komuro

    Circulation Research　Vol. 113　No. 5　p. e48-e49　2013/08/16　Rapid communication, short report, research note, etc. (scientific journal)

  21. microRNAの修飾とその機能― RNA編集，メチル化，アデニル化，ウリジル化

    余越 萌, 河原行郎

    実験医学　Vol. 第31巻　No. 第7号(増刊)　p. 160-167　2013/04　Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)

  22. microRNAの修飾とその機能

    余越萌, 河原行郎

    実験医学(増刊)　Vol. 31　No. 7　p. 1124-1131　2013

  23. 筋萎縮性側索硬化症とRNA結合タンパク質

    河原行郎

    領域融合レビュー　Vol. 2　p. e010-e010　2013

  24. ノンコーディングRNAと神経変性疾患

    河原行郎

    医学のあゆみ　Vol. 247　No. 5　p. 421-426　2013

  25. microRNA

    河原行郎

    分子脳血管病　Vol. 11　No. 4　p. 431-434　2012

  26. マイクロRNA

    河原行郎

    分子精神医学　Vol. 11　No. 3　p. 172-177　2011

  27. RNA編集の異常と関連する疾患

    河原行郎

    実験医学(増刊)　Vol. 28　p. 1628-1635　2010

  28. microRNA発現の転写後調節機構

    河原行郎

    生体の科学　Vol. 61　No. 4　p. 308-314　2010

  29. RNA編集によるmicroRNA機能調節

    河原行郎, 西倉和子

    蛋白質核酸酵素　Vol. 54　p. 1133-1140　2009

  30. RNA編集から疾患治療へ

    河原行郎, 西倉和子

    遺伝子医学MOOK　Vol. 15　p. 174-180　2009

  31. RNA編集と関連する疾患

    河原行郎, 西倉和子

    実験医学(増刊)　Vol. 26　No. 10　p. 1614-1620　2008

  32. microRNAの神経生物学

    河原行郎

    Brain and Nerve　Vol. 60　No. 12　p. 1437-1444　2008

  33. RNA編集によるsmall RNA修飾と機能制御

    河原行郎, 西倉和子

    実験医学　Vol. 25　No. 6　p. 829-835　2007

  34. RNA編集によるmicroRNA機能制御

    河原行郎, 西倉和子

    細胞　Vol. 39　No. 12　p. 493-496　2007

  35. 薬物動態変動にRNA-editingは関与するか?

    崔 吉道, 阿佐野 霞, 巨勢 典子, 中島 恵美, 河原 行郎, 飯笹 久, 西倉 和子

    薬剤学: 生命とくすり　Vol. 66　No. Suppl.　p. 221-221　2006/02

    Publisher: (公社)日本薬剤学会

  36. AMPA受容体サブユニットGluR2のRNA編集とALSにおける神経細胞死

    西本祥仁, 日出山拓人, 河原行郎, 郭伸

    Clinical Neuroscience　Vol. 24　No. 2　p. 222-225　2006

    Publisher: (株)中外医学社

  37. 筋萎縮性側索硬化症の研究の進歩

    日出山拓人, 河原行郎, 郭伸

    医学のあゆみ(増刊）　p. 83-90　2006

  38. カイニン酸持続髄注によるALSモデル動物の開発

    孫 慧, 河原 行郎, 伊藤 杏子, 金澤 一郎, 辻 省次, 郭 伸

    臨床神経学　Vol. 45　No. 12　p. 1183-1183　2005/12

    Publisher: (一社)日本神経学会

  39. ALSの分子生物学

    日出山拓人, 河原行郎, 郭伸

    Current Insights in Neurological Science　Vol. 13　No. 2　p. 2-4　2005

    Publisher: (株)マッキャンヘルスケアワールドワイドジャパン

  40. 筋萎縮性側索硬化症の研究の進歩

    日出山拓人, 河原行郎, 郭伸

    医学の歩み　Vol. 212　p. 937-944　2005

  41. 筋萎縮性側索硬化症の分子病理〜病態と治療〜

    日出山拓人, 河原行郎, 郭伸

    最新医学　Vol. 60　No. 5　p. 1072-1080　2005

  42. ALSとAMPA受容体

    日出山拓人, 河原行郎, 郭伸

    脳と神経　Vol. 57　No. 7　p. 585-589　2005

    Publisher: 医学書院

  43. ALSにおける分子生物学的変化

    西本祥仁, 日出山拓人, 河原行郎, 郭伸

    医学のあゆみ　Vol. 215　No. 8　p. 683-687　2005

    Publisher: 医歯薬出版(株)

  44. RNA編集と精神疾患

    河原行郎, 西倉和子

    脳と精神の医学　Vol. 16　No. 2　p. 103-111　2005

  45. 脳科学におけるRNA編集の重要性

    河原行郎, 郭伸

    Clinical Neuroscience　Vol. 22　No. 3　p. 250-251　2004

  46. ALSにおけるRNA編集異常と脊髄運動ニューロン死

    河原行郎, 郭伸

    医学の歩み　Vol. 209　p. 979-980　2004

  47. 筋萎縮性側索硬化症の分子標的治療への展望

    河原行郎, 日出山拓人, 郭伸

    最新医学　Vol. 59　p. 1620-1626　2004

  48. 運動ニューロン病の分子病態と治療

    日出山拓人, 河原行郎, 郭伸

    孤発性ALS、先端医療シリーズ30「神経内科の最新医療」　p. 1443-149　2004

  49. 筋萎縮性側索硬化症における運動ニューロン死の分子病態

    日出山拓人, 河原行郎, 郭伸

    内科　Vol. 94　No. 5　p. 952-961　2004

    Publisher: 南江堂

  50. AMPA型受容体の異常〜ALSをめぐる最近の動き

    河原行郎, 郭伸

    Brain Medical　Vol. 14　No. 1　p. 55-62　2002

Publications 1

  1. Post-transcriptional gene regulation by an Editor: ADAR and its role in RNA Editing.

    Valente L, Kawahara Y, Zinshteyn B, Iizasa H, Nishikura K

    Wiley-VCH book　2013/04　Scholarly book

    ISBN: 9783527322022