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Yamamoto Tomoya
山本　智也
Yamamoto Tomoya
山本　智也
Institutional repository
Graduate School of Engineering　Center for Future Innovation, Assistant Professor

keyword hydrogel，Amyloid，Solid-state NMR，Natural Product

Institutional repository

Research History 6

  1. 2022/08 - Present
    Osaka University　Graduate School of Engineering, Center for Future Innovation　Assistant Professor

  2. 2021/04 - 2022/07
    RIKEN　CPR　Special Postdoctoral Researcher

  3. 2019/07 - 2021/03
    RIKEN　Postdoctoral Fellow

  4. 2018/07 - 2019/06
    Osaka Unviersity, Graduate School of Science　Department of Chemistry　Postdoctoral Fellow

  5. 2017/07 - 2018/06
    University of Michigan　Department of Chemistry　Postdoctoral Fellow

  6. 2017/04 - 2017/06
    Graduate School of Science, Osaka Unviersity　Department of Chemistry　Postdoctoral Fellow

Education 3

  1. Osaka University　Graduate School of Science　Department of Chemistry, doctoral program

    2014/04 - 2017/03

  2. Osaka University　Graduate School of Science　Department of Chemistry, Master's program

    2012/04 - 2014/03

  3. Osaka University　Faculty of Science　Department of Biology

    2008/04 - 2012/03

Committee Memberships 1

  1. 天然物化学談話会世話人

    2023/06 - Present

Research Areas 1

  1. Nanotechnology/Materials / Molecular biochemistry /

Awards 1

  1. Student Presentation award

    Yamamoto Tomoya　The Chemical Society of Japan　2017/03

Papers 14

  1. Supramolecular hydrogelation triggered by a gold catalyst

    Tomoya Yamamoto, Akiko Nakamura, Akari Mukaimine, Katsunori Tanaka

    Tetrahedron Chem　Vol. 9　p. 100058-100058　2024/03　Research paper (scientific journal)

    Publisher: Elsevier BV

  2. Protecting Group Transformable with Gold Catalysis

    Tomoya Yamamoto, Tsung-che Chang, Katsunori Tanaka

    p. 15-16　2023/03　Research paper (international conference proceedings)

  3. Amphotericin B assembles into seven-molecule ion channels: An NMR and molecular dynamics study.

    Yuichi Umegawa, Tomoya Yamamoto, Mayank Dixit, Kosuke Funahashi, Sangjae Seo, Yasuo Nakagawa, Taiga Suzuki, Shigeru Matsuoka, Hiroshi Tsuchikawa, Shinya Hanashima, Tohru Oishi, Nobuaki Matsumori, Wataru Shinoda, Michio Murata

    Science advances　Vol. 8　No. 24　2022/06/17　Research paper (scientific journal)

  4. Prodrug Activation by Gold Artificial Metalloenzyme‐Catalyzed Synthesis of Phenanthridinium Derivatives via Hydroamination

    Tsung-Che Chang, Kenward Vong, Tomoya Yamamoto, Katsunori Tanaka

    Angewandte Chemie International Edition　Vol. 60　No. 22　p. 12446-12454　2021/04/06　Research paper (scientific journal)

    Publisher: Wiley

  5. Epoc group: transformable protecting group with gold(iii)-catalyzed fluorene formation

    Tomoya Yamamoto, Tsung-Che Chang, Katsunori Tanaka

    Chemical Science　Vol. 12　No. 32　p. 10703-10709　2021　Research paper (scientific journal)

    Publisher: Royal Society of Chemistry ({RSC})

  6. Artificial Glycoproteins as a Scaffold for Targeted Drug Therapy.

    Kenward Vong, Tomoya Yamamoto, Katsunori Tanaka

    Small (Weinheim an der Bergstrasse, Germany)　2020/02/18

  7. Unusual Two-Step Assembly of a Minimalistic Dipeptide-Based Functional Hypergelator.

    Priyadarshi Chakraborty, Yiming Tang, Tomoya Yamamoto, Yifei Yao, Tom Guterman, Shai Zilberzwige-Tal, Nofar Adadi, Wei Ji, Tal Dvir, Ayyalusamy Ramamoorthy, Guanghong Wei, Ehud Gazit

    Advanced materials (Deerfield Beach, Fla.)　2020/01/27　Research paper (scientific journal)

  8. Bioorthogonal release of anticancer drugs via gold-triggered 2-alkynylbenzamide cyclization

    Kenward Vong, Tomoya Yamamoto, Tsung-che Chang, Katsunori Tanaka

    Chemical Science　Vol. 11　No. 40　p. 10928-10933　2020　Research paper (scientific journal)

    Publisher: Royal Society of Chemistry ({RSC})

  9. The Amphotericin B–Ergosterol Complex Spans a Lipid Bilayer as a Single-Length Assembly

    Tomoya Yamamoto, Yuichi Umegawa, Hiroshi Tsuchikawa, Shinya Hanashima, Nobuaki Matsumori, Kosuke Funahashi, Sangjae Seo, Wataru Shinoda, Michio Murata

    Biochemistry　Vol. 58　No. 51　p. 5188-5196　2019/12/24　Research paper (scientific journal)

    Publisher: American Chemical Society ({ACS})

  10. The Perpendicular Orientation of Amphotericin B Methyl Ester in Hydrated Lipid Bilayers Supports the Barrel-Stave Model

    Tomoya Yamamoto, Yuichi Umegawa, Masaki Yamagami, Taiga Suzuki, Hiroshi Tsuchikawa, Shinya Hanashima, Nobuaki Matsumori, Michio Murata

    Biochemistry　Vol. 58　No. 17　p. 2282-2291　2019/04/30　Research paper (scientific journal)

    Publisher: American Chemical Society ({ACS})

  11. Nonlamellar-Phase-Promoting Colipids Enhance Segregation of Palmitoyl Ceramide in Fluid Bilayers

    Anna Möuts, Tomoya Yamamoto, Thomas K.M. Nyholm, Michio Murata, J. Peter Slotte

    Biophysical Journal　Vol. 116　No. 8　p. 1507-1515　2019/04　Research paper (scientific journal)

    Publisher: Elsevier BV

  12. Real-time monitoring of the aggregation of Alzheimer's amyloid-β via1H magic angle spinning NMR spectroscopy

    Jian Wang, Tomoya Yamamoto, Jia Bai, Sarah J. Cox, Kyle J. Korshavn, Martine Monette, Ayyalusamy Ramamoorthy

    Chemical Communications　Vol. 54　No. 16　p. 2000-2003　2018/01　Research paper (scientific journal)

    Publisher: Royal Society of Chemistry ({RSC})

  13. The Structure of the Bimolecular Complex between Amphotericin B and Ergosterol in Membranes Is Stabilized by Face-to-Face van der Waals Interaction with Their Rigid Cyclic Cores

    Yasuo Nakagawa, Yuichi Umegawa, Naohiro Matsushita, Tomoya Yamamoto, Hiroshi Tsuchikawa, Shinya Hanashima, Tohru Oishi, Nobuaki Matsumori, Michio Murata

    BIOCHEMISTRY　Vol. 55　No. 24　p. 3392-3402　2016/06　Research paper (scientific journal)

  14. Role of polyol moiety of amphotericin B in ion channel formation and sterol selectivity in bilayer membrane

    Tomoya Yamamoto, Yuichi Umegawa, Hiroshi Tsuchikawa, Nobuaki Matsumori, Shinya Hanashima, Michio Murata, Resul Haser, Bernard J. Rawlings, Patrick Caffrey

    BIOORGANIC & MEDICINAL CHEMISTRY　Vol. 23　No. 17　p. 5782-5788　2015/09　Research paper (scientific journal)

Misc. 3

  1. 人工金属酵素を用いたマウス生体内での金触媒反応

    Catalyst & Catalysis　Vol. 63　No. 1　p. 33-38　2021/01　Article, review, commentary, editorial, etc. (scientific journal)

  2. 人工金属酵素による生体内での有機合成の実現と機能発現

    山本智也, 田中克典

    バイオサイエンスとインダストリー　Vol. 78　No. 4　p. 315-320　2020/07/10　Article, review, commentary, editorial, etc. (scientific journal)

  3. Structure Elucidation of Ion Channel Assembly Formed by Amphotericin B and Sterol

    山本智也, 山本智也, 梅川雄一, 梅川雄一, 中川泰男, 鈴木大河, 山上正輝, 土川博史, 花島慎弥, 村田道雄, 村田道雄, 松森信明, 松森信明, SEO Sangjae, 篠田渉

    天然有機化合物討論会講演要旨集(Web)　Vol. 60th　2018

Presentations 46

  1. Dual-emission fluorescent probes for ratiometric imaging of membrane fluidity

    Tomoya Yamamoto, Nozomi Sugi, Kazuya Kikuchi

    The 19th Annual Meeting of Japanese Society for Chemical Biology　2025/06/05

  2. Development of nanostructured lipid carrier for 19F MRI probe

    Shiho Sugiura, Tomoya Yamamoto, Kazuya Kikuchi

    2025/05/29

  3. Development of small 19F MRI probe using lipid nanodisc

    Kodai Fukushima, Tomoya Yamamoto, Kazuya Kikuchi

    The 105th CSJ Annual Meeting　2025/03/26

  4. Development of nanostructured lipid carrier for 19F MRI probe

    Shiho Sugiura, Tomoya Yamamoto, Kazuya Kikuchi

    The 105th CSJ Annual Meeting　2025/03/26

  5. Tetrazine-based fluorogenic probe toward leaflet-selective polarity imaging of cell membranes

    Yusei Otsuka, Tomoya Yamamoto, Kazuya Kikuchi

    The 105th CSJ Annual Meeting　2025/03/28

  6. レシオイメージングにより液滴の成熟を検知する蛍光プローブの開発研究

    森 明日香, 山本 智也, 菊地 和也

    第33回日本バイオイメージング学会学術集会　2024/09/29

  7. 脂質膜の微小な流動性の違いを検知するレシオメトリック型蛍光プローブの開発

    杉望未, 山本智也, 菊地和也

    第33回日本バイオイメージング学会学術集会　2024/09/29

  8. ナノ構造脂質キャリアを用いた19F MRI造影剤の開発研究

    杉浦 志帆, 山本 智也, 菊地 和也

    第18回バイオ関連化学シンポジウム　2024/09/12

  9. Development of polarity-responsive fluorogenic probes activated by click reactions

    Yusei Otsuka, Tomoya Yamamoto, Kazuya Kikuchi

    The 18th Annual Meeting of Japanese Society for Chemical Biology　2024/05/27

  10. Development of 19F-labeled lipid nanodisc for 19F MRI

    Kodai Fukushima, Tomoya Yamamoto, Kazuya Kikuchi

    FASMI-JSMI Joint Meeting 2024　2024/05/23

  11. Supramolecular hydrogelation triggered by gold catalysis

    Tomoya Yamamoto, Akiko Nakamura, Akari Mukaimine, Katsunori Tanaka

    2024/03/21

  12. Development of 19F MRI probe using gelled emulsion

    Shiho Sugiura, Tomoya Yamamoto, Kazuya Kikuchi

    2024/03/20

  13. Development of fluorescent probes to detect maturation of liquid droplets

    Asuka Mori, Tomoya Yamamoto, Kazuya Kikuchi

    2024/03/19

  14. Development of a fluorescent probe to discriminate Lo/Ld phases of lipid membranes

    Nozomi Sugi, Tomoya Yamamoto, Kazuya Kikuchi

    2024/03/19

  15. Development of 19F MRI probe using gelled emulsion

    Shiho Sugiura, Tomoya Yamamoto, Kazuya Kikuchi

    The 11th Takeda Science Foundation Symposium on PharmaSciences　2024/01/26

  16. Low-molecular-weight gelator responsive to gold catalyst

    Tomoya Yamamoto, Akiko Nakamura, Akari Mukaimine, Katsunori Tanaka

    The 11th Takeda Science Foundation Symposium on Pharma Sciences　2024/01/26

  17. Development of 19F MRI probe using lipid nanodisc

    Kodai Fukushima, Tomoya Yamamoto, Kazuya Kikuchi

    Chemical Biology and Physiology 2023　2023/12/16

  18. Development of a fluorescent probe for detection of maturation of liquid droplets

    MORI, Asuka, YAMAMOTO, Tomoya, KIKUCHI Kazuya

  19. Development of 19F MRI probe using phospholipid nanodiscs

    FUKUSHIMA, Kodai, YAMAMOTO, Tomoya, KIKUCHI, Kazuya

  20. Development of Ultrasmall Core-shell Silica Nanoparticles for 19F Magnetic Resonance Imaging

    Yue Wu, Masafumi Minoshima, Kazuya Kikuchi, Tomoya Yamamoto

    World Molecular Imaging Congress 2023　2023/09/07

  21. Plasmin-responsive fluorine MRI probe for imaging inflammation in vivo

    Tomoya Yamamoto, Jeremy Salaam, Fuminori Sugihara, Yuya Otera, Masafumi Minoshima, Kazuya Kikuchi

    World Molecular Imaging Congress 2023　2023/09/07

  22. Development of 19F MRI probe using phospholipid nanodiscs

    Kodai Fukushima, Tomoya Yamamoto, Kazuya Kikuchi

    The 103rd CSJ Annual Meeting　2023/03/22

  23. Supramolecular hydrogelation triggered by gold catalysis

    Tomoya Yamamoto, Katsunori Tanaka

    2023/02/17

  24. Development of methods for in vivo hydrogelation triggered by benzannulation

    Tomoya Yamamoto

    FY2022 SPDR presentation session　2023/01/18

  25. Conformation and self-assembled structure of antifungal glycoside amphotericin B in lipid bilayers

    Tomoya Yamamoto

    20th Glyco-lipidologue seminar　2022/11/04

  26. Protecting group transformable with gold catalysis and application to supramolecular gel

    Tomoya Yamamoto, Tsung-che Chang, Akiko Nakamura, Katsunori Tanaka

    The 59th Japanese Peptide Symposium　2022/10/27

  27. 固体NMRを用いた分子複合体の構造解析

    山本 智也

    グローバル若手研究者フロンティア研究拠点シンポジウム　2022/09/26

  28. Bioorthogonal fluorene formation toward synthesis of supramolecular materials in vivo

    Tomoya Yamamoto, Katsunori Tanaka

    The 102nd CSJ Annual Meeting　2022/03/25

  29. Epoc group: protecting group transformable with gold catalysis

    Tomoya Yamamoto, Tsung-che Chang, Katsunori Tanaka

    The 40th Annual Meeting of Japanese Society of Carbohydrate Research　2021/10/27

  30. 金触媒によって活性化される opened-Fmoc 保護基の開発

    山本智也, 田中克典

    日本化学会第101春季年会　2021/03/20

  31. 金錯体を活性中心に持つ新規生体内触媒の開発と治療への展開

    山本智也, Tsung-Che Chang, Kenward Vong, 田中克典

    日本化学会第100春季年会　2020/03/24

  32. Synthesis of novel 2H, 13C labeled Amphotericin B and orientation analysis of mycosamine

    Tomoya Yamamoto, Yuichi Umegawa, Taiga Suzuki, Hiroshi Tsuchikawa, Shinya Hanashima, Michio Murata, Nobuaki Matsumori, Sangjae Seo, Kosuke Funahashi, Wataru Shinoda

    The 14th Annual Meeting of Japanese Society for Chemical Biology　2019/06/11

  33. Synthesis of novel 13C, 2H-labeled Amphotericin B and the conformational analysis of glycosidic linkage in lipid bilayers

    Tomoya Yamamoto, Yuichi Umegawa, Taiga Suzuki, Hiroshi Tsuchikawa, Shinya Hanashima, Michio Murata, Nobuaki Matsumori, Sangjae Seo, Kosuke Funahashi, Wataru Shinoda

    2019/03/17

  34. Structure Elucidation of Ion Channel Assembly Formed by Amphotericin B and Sterol

    Tomoya Yamamoto, Yuichi Umegawa, Yasuo Nakagawa, Taiga Suzuki, Masaki Yamagami, Hiroshi Tsuchikawa, Shinya Hanashima, Michio Murata, Nobuaki Matsumori, Sangjae Seo, Wataru Shinoda

    2018/09

  35. Solid state NMR study for the molecular orientation of amphotericin B in membrane

    Yamamoto Tomoya, Yuichi Umegawa, Masaki Yamagami, Shinya Hanashima, Hiroshi Tsuchikawa, Nobuaki Matsumori, Michio, Murata

    2017/03

  36. 2H, 19F NMRを用いた脂質膜中におけるアンフォテリシンBの配向解析

    山本智也, 梅川雄一, 山上正輝, 花島慎弥, 土川博史, 松森信明, 村田道雄

    第55回 NMR討論会　2016/11/17

  37. βグリコシド結合の配座解明を目指した新規二重標識化アンフォテリシンBの合成研究

    山本智也

    第51回 天然物化学談話会　2016/07/04

  38. アンフォテリシンBのチャネル形成機構解明を目指した構造活性相関研究

    山本智也, 梅川雄一, 土川博史, 松森信明, 花島慎弥, 村田道雄, Resul Haser・Bernard J. Rawlings, Patrick Caffrey

    日本薬学会 第136年会：大学院生シンポジウム『復興する天然物化学 -新研究が明かす次世代天然物創薬の可能性-』　2016/03

  39. Role of polyl moiety of amphotericin B in permeabilizing membrane

    Tomoya Yamamoto, Yuichi Umegawa, Hiroshi Tsuchikawa, Nobuaki Matsumori, Shinya Hanashima, Michio Murata, Resul Haser, Bernard J. Rawlings, Patrick Caffrey

    16th Tetrahedron Symposium Asia Edition: Challenges in Bioorganic & Organic Chemistry　2015/11

  40. アンフォテリシンBチャネル複合体におけるポリオール部分の構造活性相関研究

    山本智也

    第50回 天然物化学談話会　2015/07/02

  41. ポリオール部分の相互作用解明を目指した新規アンフォテリシンB誘導体の調製とイオンチャネル活性

    山本智也, 梅川雄一, 土川博史, 花島慎弥, 村田道雄, 松森信明, Patrick Caffrey

    2015/03

  42. New synthetic route for labelled Amphotericin B derivative via β glycosidation

    Tomoya Yamamoto, Yuichi Umegawa, Hiroshi Tsuchikawa, Shinya Hanashima, Nobuaki Matsumori, Michio Murata

    The 3rd International Symposium on Chemical Biology of Natural Products: Target ID and Regulation of Bioactivity　2014/10

  43. Synthesis of deuterated Amphotericin B derivative via beta-glycosidation

    Tomoya Yamamoto, Yuichi Umegawa, Hiroshi Tsuchikawa, Shinya Hanashima, Nobuaki Matsumori, Michio Murata

    Gordon Research Conference: Natural Products, Proctor Academy in Andover　2014/07

  44. 新規重水素化アンフォテリシンB誘導体の合成と固体NMRによる配向解析

    山本智也, 梅川雄一, 土川博史, 花島慎弥, 松森信明, 村田道雄

    日本化学会 第94春季年会　2014/03

  45. チャネル複合体の構造解析を目指したアンフォテリシンB新規標識体の合成研究

    山本智也

    第48回 天然物化学談話会　2013/07/03

  46. マイコサミン部分の配向解析を目指したアンフォテリシンB標識体の合成研究

    山本智也, 梅川雄一, 中川泰男, 土川博史, 松森信明, 村田道雄

    第2回 CSJ化学フェスタ 2012　2012/10/16

Institutional Repository 2

Content Published in the University of Osaka Institutional Repository (OUKA)

  1. The effect of aprepitant and dexamethasone combination on paclitaxel-induced hypersensitivity reaction

    山本 智也

  2. 分子内構造情報に着目したアンフォテリシンBチャネル複合体の構造解析

    山本 智也