CTLA-4-expressing ILC3s restrain interleukin-23-mediated inflammation

Anees Ahmed, Ann M. Joseph, Jordan Zhou, Veronika Horn, Jazib Uddin, Mengze Lyu, Jeremy Goc, David Artis, Randy Longman, Gregory F. Sonnenberg, Ellen Scherl, Robbyn Sockolow, Dana Lukin, Vinita Jacob, Laura Sahyoun, Michael Mintz, Lasha Gogokhia, Thomas Ciecierega, Aliza Solomon, Arielle Bergman, Kimberley Chein, Elliott Gordon, Michelle Ramos, Victoria Ribeiro de Godoy, Adriana Brcic-Susak, Seun Oguntunmibi, Dario Garone, Caitlin Mason, Robbyn E. Sockolow, James B. Wing, Eric Vivier, Shimon Sakaguchi, Gregory F. Sonnenberg

Nature　Vol. 630　No. 8018　p. 976-983　2024/06/12　Research paper (scientific journal)

Neural-net-based cell deconvolution from DNA methylation reveals tumor microenvironment associated with cancer prognosis.

Yoshiaki Yasumizu, Masaki Hagiwara, Yuto Umezu, Hiroaki Fuji, Keiko Iwaisako, Masataka Asagiri, Shinji Uemoto, Yamami Nakamura, Sophia Thul, Azumi Ueyama, Kazunori Yokoi, Atsushi Tanemura, Yohei Nose, Takuro Saito, Hisashi Wada, Mamoru Kakuda, Masaharu Kohara, Satoshi Nojima, Eiichi Morii, Yuichiro Doki, Shimon Sakaguchi, Naganari Ohkura

NAR cancer　Vol. 6　No. 2　2024/06　Research paper (scientific journal)

Single cell suppression profiling of human regulatory T cells

Jonas Søndergaard, Janyerkye Tulyeu, David Priest, Shimon Sakaguchi, James Wing

2024/05/02

Downregulation of TCF7 and LEF1 is a key determinant of tumor-infiltrating regulatory T-cell function

Yujiro Kidani, Yohko Kitagawa, Masaki Hagiwara, Atsunari Kawashima, Takayuki Kanazawa, Hisashi Wada, Motohide Uemura, Norio Nonomura, Daisuke Motooka, Shota Nakamura, Naganari Ohkura, Shimon Sakaguchi

International Immunology　Vol. 36　No. 4　p. 167-182　2024/04/01　Research paper (scientific journal)

Regulatory T Cells for Control of Autoimmunity

Ryoji Kawakami, Shimon Sakaguchi

Advances in Experimental Medicine and Biology　p. 67-82　2024/03/12　Part of collection (book)

Th17 cells with a pathogenic signature in joints of ZAP-70 mutant arthritic mice harbor unique TCR repertoires that share features with WT Tregs

Mara Llamas-Covarrubias, Atsushi Tanaka, Martin Loza, Diego Diez, Zichang Xu, Ee Lyn Lim, Shunsuke Teraguchi, Shimon Sakaguchi, Daron Standley

bioRxiv　2024/03/04

Natural Treg Development in the Thymus

Ryoji Kawakami, Yohko Kitagawa, Shimon Sakaguchi

Reference Module in Life Sciences　2024　Part of collection (book)

Single-cell transcriptome landscape of circulating CD4+ T cell populations in autoimmune diseases

Yoshiaki Yasumizu, Daiki Takeuchi, Reo Morimoto, Yusuke Takeshima, Tatsusada Okuno, Makoto Kinoshita, Takayoshi Morita, Yasuhiro Kato, Min Wang, Daisuke Motooka, Daisuke Okuzaki, Yamami Nakamura, Norihisa Mikami, Masaya Arai, Xuan Zhang, Atsushi Kumanogoh, Hideki Mochizuki, Naganari Ohkura, Shimon Sakaguchi

Cell Genomics　p. 100473-100473　2024/01　Research paper (scientific journal)

Nrf2 activation improves experimental rheumatoid arthritis

Anqi Zhang, Takafumi Suzuki, Saki Adachi, Eiki Yoshida, Shimon Sakaguchi, Masayuki Yamamoto

Free Radical Biology and Medicine　2023/10　Research paper (scientific journal)

A genetic method specifically delineates Th1-type Treg cells and their roles in tumor immunity

Masaaki Okamoto, Miwa Sasai, Ayumi Kuratani, Daisuke Okuzaki, Masaya Arai, James B. Wing, Shimon Sakaguchi, Masahiro Yamamoto

Cell Reports　Vol. 42　No. 7　p. 112813-112813　2023/07/25　Research paper (scientific journal)

Regulatory T cells in autoimmune kidney diseases and transplantation.

Norihisa Mikami, Shimon Sakaguchi

Nature reviews. Nephrology　2023/07/03　Research paper (scientific journal)

Tumor-infiltrating regulatory T cells as targets of cancer immunotherapy

Christopher Tay, Atsushi Tanaka, Shimon Sakaguchi

Cancer Cell　Vol. 41　No. 3　p. 450-465　2023/03　Research paper (scientific journal)

Construction of a T cell receptor signaling range for spontaneous development of autoimmune disease.

Atsushi Tanaka, Shinji Maeda, Takashi Nomura, Mara Anais Llamas-Covarrubias, Satoshi Tanaka, Lin Jin, Ee Lyn Lim, Hiromasa Morikawa, Yohko Kitagawa, Shuji Akizuki, Yoshinaga Ito, Chihiro Fujimori, Keiji Hirota, Tosei Murase, Motomu Hashimoto, Junichi Higo, Rose Zamoyska, Ryuzo Ueda, Daron M Standley, Noriko Sakaguchi, Shimon Sakaguchi

The Journal of experimental medicine　Vol. 220　No. 2　2023/02/06　Research paper (scientific journal)

A sex-biased imbalance between Tfr, Tph, and atypical B cells determines antibody responses in COVID-19 patients.

Jonas Nørskov Søndergaard, Janyerkye Tulyeu, Ryuya Edahiro, Yuya Shirai, Yuta Yamaguchi, Teruaki Murakami, Takayoshi Morita, Yasuhiro Kato, Haruhiko Hirata, Yoshito Takeda, Daisuke Okuzaki, Shimon Sakaguchi, Atsushi Kumanogoh, Yukinori Okada, James Badger Wing

Proceedings of the National Academy of Sciences of the United States of America　Vol. 120　No. 4　2023/01/24　Research paper (scientific journal)

Treg-based immunotherapy for antigen-specific immune suppression and stable tolerance induction: a perspective

Shimon Sakaguchi, Ryoji Kawakami, Norihisa Mikami

Immunotherapy Advances　Vol. 3　No. 1　2023/01/01　Research paper (scientific journal)

Mature dendritic cells enriched in regulatory molecules may control regulatory T cells and the prognosis of head and neck cancer.

Kiyoshi Minohara, Masaki Imai, Takuma Matoba, James Badger Wing, Hiroaki Shime, Mizuyu Odanaka, Ryuta Uraki, Daisuke Kawakita, Tatsuya Toyama, Satoru Takahashi, Akimichi Morita, Shingo Murakami, Naganari Ohkura, Shimon Sakaguchi, Shinichi Iwasaki, Sayuri Yamazaki

Cancer science　Vol. 114　No. 4　p. 1256-1269　2022/12/18　Research paper (scientific journal)

Protocol to evaluate cell lineage stability of mouse natural and induced regulatory T cells using bisulfite sequencing.

Masaya Arai, Aine Fukuda, Reo Morimoto, Yamami Nakamura, Zhaohong Ci, Shimon Sakaguchi

STAR protocols　Vol. 3　No. 4　p. 101694-101694　2022/09/17　Research paper (scientific journal)

PGE2-EP2/EP4 signaling elicits immunosuppression by driving the mregDC-Treg axis in inflammatory tumor microenvironment

Dean Thumkeo, Siwakorn Punyawatthananukool, Somsak Prasongtanakij, Ryuma Matsuura, Kentaro Arima, Huan Nie, Rie Yamamoto, Naohiro Aoyama, Hisao Hamaguchi, Shingo Sugahara, Shinobu Takeda, Varodom Charoensawan, Atsushi Tanaka, Shimon Sakaguchi, Shuh Narumiya

Cell Reports　Vol. 39　No. 10　p. 110914-110914　2022/06　Research paper (scientific journal)

The ratio of CD8 + lymphocytes to tumor-infiltrating suppressive FOXP3 + effector regulatory T cells is associated with treatment response in invasive breast cancer.

Noriko Goda, Shinsuke Sasada, Hideo Shigematsu, Norio Masumoto, Koji Arihiro, Hiroyoshi Nishikawa, Shimon Sakaguchi, Morihito Okada, Takayuki Kadoya

Discover. Oncology　Vol. 13　No. 1　p. 27-27　2022/04/19　Research paper (scientific journal)

Effect of Impaired T Cell Receptor Signaling on the Gut Microbiota in a Mouse Model of Systemic Autoimmunity.

Mirei Shirakashi, Mikako Maruya, Keiji Hirota, Tatsuaki Tsuruyama, Takashi Matsuo, Ryu Watanabe, Koichi Murata, Masao Tanaka, Hiromu Ito, Hajime Yoshifuji, Koichiro Ohmura, Dirk Elewaut, Shimon Sakaguchi, Sidonia Fagarasan, Tsuneyo Mimori, Motomu Hashimoto

Arthritis & rheumatology (Hoboken, N.J.)　Vol. 74　No. 4　p. 641-653　2022/04　Research paper (scientific journal)

CCR8-targeted specific depletion of clonally expanded Treg cells in tumor tissues evokes potent tumor immunity with long-lasting memory.

Yujiro Kidani, Wataru Nogami, Yoshiaki Yasumizu, Atsunari Kawashima, Atsushi Tanaka, Yudai Sonoda, Yumi Tona, Kunitaka Nashiki, Reimi Matsumoto, Masaki Hagiwara, Motonao Osaki, Keiji Dohi, Takayuki Kanazawa, Azumi Ueyama, Mai Yoshikawa, Tetsuya Yoshida, Mitsunobu Matsumoto, Kanji Hojo, Satomi Shinonome, Hiroshi Yoshida, Michinari Hirata, Miya Haruna, Yamami Nakamura, Daisuke Motooka, Daisuke Okuzaki, Yasuko Sugiyama, Makoto Kinoshita, Tatsusada Okuno, Taigo Kato, Koji Hatano, Motohide Uemura, Ryoichi Imamura, Kazunori Yokoi, Atsushi Tanemura, Yasushi Shintani, Tadashi Kimura, Norio Nonomura, Hisashi Wada, Masaki Mori, Yuichiro Doki, Naganari Ohkura, Shimon Sakaguchi

Proceedings of the National Academy of Sciences of the United States of America　Vol. 119　No. 7　2022/02/15　Research paper (scientific journal)

B cell-intrinsic TBK1 is essential for germinal center formation during infection and vaccination in mice.

Michelle S J Lee, Takeshi Inoue, Wataru Ise, Julia Matsuo-Dapaah, James B Wing, Burcu Temizoz, Kouji Kobiyama, Tomoya Hayashi, Ashwini Patil, Shimon Sakaguchi, A Katharina Simon, Jelena S Bezbradica, Satoru Nagatoishi, Kouhei Tsumoto, Jun-Ichiro Inoue, Shizuo Akira, Tomohiro Kurosaki, Ken J Ishii, Cevayir Coban

The Journal of experimental medicine　Vol. 219　No. 2　2022/02/07　Research paper (scientific journal)

Using Mass Cytometry to Address Tfh and Tfr Heterogeneity.

James B Wing, Shimon Sakaguchi

Methods in molecular biology (Clifton, N.J.)　Vol. 2380　p. 47-57　2022　Research paper (scientific journal)

Alteration of the immune environment in bone marrow from children with recurrent B cell precursor acute lymphoblastic leukemia.

Takashi Mikami, Itaru Kato, James Badger Wing, Hiroo Ueno, Keiji Tasaka, Kuniaki Tanaka, Hirohito Kubota, Satoshi Saida, Katsutsugu Umeda, Hidefumi Hiramatsu, Tomoya Isobe, Mitsuteru Hiwatari, Ai Okada, Kenichi Chiba, Yuichi Shiraishi, Hiroko Tanaka, Satoru Miyano, Yuki Arakawa, Koichi Oshima, Katsuyoshi Koh, Souichi Adachi, Keiko Iwaisako, Seishi Ogawa, Shimon Sakaguchi, Junko Takita

Cancer science　Vol. 113　No. 1　p. 41-52　2022/01　Research paper (scientific journal)

Myasthenia gravis-specific aberrant neuromuscular gene expression by medullary thymic epithelial cells in thymoma

Yoshiaki Yasumizu, Naganari Ohkura, Hisashi Murata, Makoto Kinoshita, Soichiro Funaki, Satoshi Nojima, Kansuke Kido, Masaharu Kohara, Daisuke Motooka, Daisuke Okuzaki, Shuji Suganami, Eriko Takeuchi, Yamami Nakamura, Yusuke Takeshima, Masaya Arai, Satoru Tada, Meinoshin Okumura, Eiichi Morii, Yasushi Shintani, Shimon Sakaguchi, Tatsusada Okuno, Hideki Mochizuki

Nature communications　Vol. 13　No. 1　p. 4230-4230　2021/12/21　Research paper (scientific journal)

Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition).

Andrea Cossarizza, Hyun-Dong Chang, Andreas Radbruch, Sergio Abrignani, Richard Addo, Mübeccel Akdis, Immanuel Andrä, Francesco Andreata, Francesco Annunziato, Eduardo Arranz, Petra Bacher, Sudipto Bari, Vincenzo Barnaba, Joana Barros-Martins, Dirk Baumjohann, Cristian G Beccaria, David Bernardo, Dominic A Boardman, Jessica Borger, Chotima Böttcher, Leonie Brockmann, Marie Burns, Dirk H Busch, Garth Cameron, Ilenia Cammarata, Antonino Cassotta, Yinshui Chang, Fernando Gabriel Chirdo, Eleni Christakou, Luka Čičin-Šain, Laura Cook, Alexandra J Corbett, Rebecca Cornelis, Lorenzo Cosmi, Martin S Davey, Sara De Biasi, Gabriele De Simone, Genny Del Zotto, Michael Delacher, Francesca Di Rosa, James Di Santo, Andreas Diefenbach, Jun Dong, Thomas Dörner, Regine J Dress, Charles-Antoine Dutertre, Sidonia B G Eckle, Pascale Eede, Maximilien Evrard, Christine S Falk, Markus Feuerer, Simon Fillatreau, Aida Fiz-Lopez, Marie Follo, Gemma A Foulds, Julia Fröbel, Nicola Gagliani, Giovanni Galletti, Anastasia Gangaev, Natalio Garbi, José Antonio Garrote, Jens Geginat, Nicholas A Gherardin, Lara Gibellini, Florent Ginhoux, Dale I Godfrey, Paola Gruarin, Claudia Haftmann, Leo Hansmann, Christopher M Harpur, Adrian C Hayday, Guido Heine, Daniela Carolina Hernández, Martin Herrmann, Oliver Hoelsken, Qing Huang, Samuel Huber, Johanna E Huber, Jochen Huehn, Michael Hundemer, William Y K Hwang, Matteo Iannacone, Sabine M Ivison, Hans-Martin Jäck, Peter K Jani, Baerbel Keller, Nina Kessler, Steven Ketelaars, Laura Knop, Jasmin Knopf, Hui-Fern Koay, Katja Kobow, Katharina Kriegsmann, H Kristyanto, Andreas Krueger, Jenny F Kuehne, Heike Kunze-Schumacher, Pia Kvistborg, Immanuel Kwok, Daniela Latorre, Daniel Lenz, Megan K Levings, Andreia C Lino, Francesco Liotta, Heather M Long, Enrico Lugli, Katherine N MacDonald, Laura Maggi, Mala K Maini, Florian Mair, Calin Manta, Rudolf Armin Manz, Mir-Farzin Mashreghi, Alessio Mazzoni, James McCluskey, Henrik E Mei, Fritz Melchers, Susanne Melzer, Dirk Mielenz, Leticia Monin, Lorenzo Moretta, Gabriele Multhoff, Luis Enrique Muñoz, Miguel Muñoz-Ruiz, Franziska Muscate, Ambra Natalini, Katrin Neumann, Lai Guan Ng, Antonia Niedobitek, Jana Niemz, Larissa Nogueira Almeida, Samuele Notarbartolo, Lennard Ostendorf, Laura J Pallett, Amit A Patel, Gulce Itir Percin, Giovanna Peruzzi, Marcello Pinti, A Graham Pockley, Katharina Pracht, Immo Prinz, Irma Pujol-Autonell, Nadia Pulvirenti, Linda Quatrini, Kylie M Quinn, Helena Radbruch, Hefin Rhys, Maria B Rodrigo, Chiara Romagnani, Carina Saggau, Shimon Sakaguchi, Federica Sallusto, Lieke Sanderink, Inga Sandrock, Christine Schauer, Alexander Scheffold, Hans U Scherer, Matthias Schiemann, Frank A Schildberg, Kilian Schober, Janina Schoen, Wolfgang Schuh, Thomas Schüler, Axel R Schulz, Sebastian Schulz, Julia Schulze, Sonia Simonetti, Jeeshan Singh, Katarzyna M Sitnik, Regina Stark, Sarah Starossom, Christina Stehle, Franziska Szelinski, Leonard Tan, Attila Tarnok, Julia Tornack, Timothy I M Tree, Jasper J P van Beek, Willem van de Veen, Klaas van Gisbergen, Chiara Vasco, Nikita A Verheyden, Anouk von Borstel, Kirsten A Ward-Hartstonge, Klaus Warnatz, Claudia Waskow, Annika Wiedemann, Anneke Wilharm, James Wing, Oliver Wirz, Jens Wittner, Jennie H M Yang, Juhao Yang

European journal of immunology　Vol. 51　No. 12　p. 2708-3145　2021/12　Research paper (scientific journal)

Isolation and Characterization of Both Human and Mouse Tfh/Tfr Cells.

Janyerkye Tulyeu, Jonas N Søndergaard, Shimon Sakaguchi, James B Wing

Current protocols　Vol. 1　No. 11　2021/11　Research paper (scientific journal)

Dispensable roles of Gsdmd and Ripk3 in sustaining IL-1β production and chronic inflammation in Th17-mediated autoimmune arthritis.

Yusuke Takeuchi, Daiya Ohara, Hitomi Watanabe, Noriko Sakaguchi, Shimon Sakaguchi, Gen Kondoh, Akio Morinobu, Tsuneyo Mimori, Keiji Hirota

Scientific reports　Vol. 11　No. 1　p. 18679-18679　2021/09/21　Research paper (scientific journal)

Arid5a Promotes Immune Evasion by Augmenting Tryptophan Metabolism and Chemokine Expression.

Gyanu Parajuli, Murat Tekguc, James B Wing, Ari Hashimoto, Daisuke Okuzaki, Takeshi Hirata, Atsushi Sasaki, Takahide Itokazu, Haruka Handa, Hirokazu Sugino, Yoshihiro Nishikawa, Hozaifa Metwally, Yuzo Kodama, Shinya Tanaka, Hisataka Sabe, Toshihide Yamashita, Shimon Sakaguchi, Tadamitsu Kishimoto, Shigeru Hashimoto

Cancer immunology research　Vol. 9　No. 8　p. 862-876　2021/08　Research paper (scientific journal)

Treg-expressed CTLA-4 depletes CD80/CD86 by trogocytosis, releasing free PD-L1 on antigen-presenting cells.

Murat Tekguc, James Badger Wing, Motonao Osaki, Jia Long, Shimon Sakaguchi

Proceedings of the National Academy of Sciences of the United States of America　Vol. 118　No. 30　2021/07/27　Research paper (scientific journal)

Taking regulatory T cells into medicine.

Shimon Sakaguchi

The Journal of experimental medicine　Vol. 218　No. 6　2021/06/07　Research paper (scientific journal)

Brazilian green propolis promotes TNFR2 expression on regulatory T cells

Norihisa Mikami, Hiroko Tani, Ryoji Kawakami, Atsushi Sugimoto, Shimon Sakaguchi, Tomoki Ikuta

Food Science & Nutrition　Vol. 9　No. 6　p. 3200-3208　2021/06　Research paper (scientific journal)

Distinct Foxp3 enhancer elements coordinate development, maintenance, and function of regulatory T cells

Ryoji Kawakami, Yohko Kitagawa, Kelvin Y. Chen, Masaya Arai, Daiya Ohara, Yamami Nakamura, Keiko Yasuda, Motonao Osaki, Norihisa Mikami, Caleb A. Lareau, Hitomi Watanabe, Gen Kondoh, Keiji Hirota, Naganari Ohkura, Shimon Sakaguchi

Immunity　Vol. 54　No. 5　p. 947-961.e8　2021/05　Research paper (scientific journal)

CTLA-4 expression by B-1a B cells is essential for immune tolerance.

Yang Yang, Xiao Li, Zhihai Ma, Chunlin Wang, Qunying Yang, Miranda Byrne-Steele, Rongjian Hong, Qing Min, Gao Zhou, Yong Cheng, Guang Qin, Justin V Youngyunpipatkul, James B Wing, Shimon Sakaguchi, Christian Toonstra, Lai-Xi Wang, Jose G Vilches-Moure, Denong Wang, Michael P Snyder, Ji-Yang Wang, Jian Han, Leonore A Herzenberg

Nature communications　Vol. 12　No. 1　p. 525-525　2021/01/22　Research paper (scientific journal)

Reply to Slominski et al.: UVB irradiation induces proenkephalin+ regulatory T cells with a wound-healing function

Hiroaki Shime, Mizuyu Odanaka, Makoto Tsuiji, Takuma Matoba, Masaki Imai, Yoshiaki Yasumizu, Ryuta Uraki, Kiyoshi Minohara, Maiko Watanabe, Anthony John Bonito, Hidehiro Fukuyama, Naganari Ohkura, Shimon Sakaguchi, Akimichi Morita, Sayuri Yamazaki

Proceedings of the National Academy of Sciences　Vol. 118　No. 3　p. e2021919118-e2021919118　2021/01/19　Research paper (scientific journal)

Hyper-Progressive Disease: The Potential Role and Consequences of T-Regulatory Cells Foiling Anti-PD-1 Cancer Immunotherapy.

Christopher Tay, Yamin Qian, Shimon Sakaguchi

Cancers　Vol. 13　No. 1　2020/12/26　Research paper (scientific journal)

New Treg cell-based therapies of autoimmune diseases: towards antigen-specific immune suppression

Norihisa Mikami, Ryoji Kawakami, Shimon Sakaguchi

Current Opinion in Immunology　Vol. 67　p. 36-41　2020/12　Research paper (scientific journal)

VIRTUS: a pipeline for comprehensive virus analysis from conventional RNA-seq data

Yoshiaki Yasumizu, Atsushi Hara, Shimon Sakaguchi, Naganari Ohkura

Bioinformatics　2020/10/05　Research paper (scientific journal)

Scalable, multimodal profiling of chromatin accessibility and protein levels in single cells

Eleni P. Mimitou, Caleb A. Lareau, Kelvin Y. Chen, Andre L. Zorzetto-Fernandes, Yusuke Takeshima, Wendy Luo, Tse-Shun Huang, Bertrand Yeung, Pratiksha I. Thakore, James Badger Wing, Kristopher L. Nazor, Shimon Sakaguchi, Leif S. Ludwig, Vijay G. Sankaran, Aviv Regev, Peter Smibert

Nature biotechnology　Vol. 39　No. 10　p. 1246-1258　2020/09/08　Research paper (scientific journal)

Proenkephalin+ regulatory T cells expanded by ultraviolet B exposure maintain skin homeostasis with a healing function.

Hiroaki Shime, Mizuyu Odanaka, Makoto Tsuiji, Takuma Matoba, Masaki Imai, Yoshiaki Yasumizu, Ryuta Uraki, Kiyoshi Minohara, Maiko Watanabe, Anthony John Bonito, Hidehiro Fukuyama, Naganari Ohkura, Shimon Sakaguchi, Akimichi Morita, Sayuri Yamazaki

Proceedings of the National Academy of Sciences of the United States of America　Vol. 117　No. 34　p. 20696-20705　2020/08/07　Research paper (scientific journal)

Dynamics of effector and naïve Regulatory T cells throughout pregnancy.

Naoya Shigeta, Keiichi Kumasawa, Atsushi Tanaka, James Badger Wing, Hitomi Nakamura, Shimon Sakaguchi, Tadashi Kimura

Journal of reproductive immunology　Vol. 140　p. 103135-103135　2020/08　Research paper (scientific journal)

Regulatory T Cell-Specific Epigenomic Region Variants Are a Key Determinant of Susceptibility to Common Autoimmune Diseases.

Naganari Ohkura, Yoshiaki Yasumizu, Yohko Kitagawa, Atsushi Tanaka, Yamami Nakamura, Daisuke Motooka, Shota Nakamura, Yukinori Okada, Shimon Sakaguchi

Immunity　Vol. 52　No. 6　p. 1119-1132　2020/06/16　Research paper (scientific journal)

Epigenetic conversion of conventional T cells into regulatory T cells by CD28 signal deprivation

Norihisa Mikami, Ryoji Kawakami, Kelvin Y. Chen, Atsushi Sugimoto, Naganari Ohkura, Shimon Sakaguchi

Proceedings of the National Academy of Sciences　Vol. 117　No. 22　p. 12258-12268　2020/06/02　Research paper (scientific journal)

Control of foreign Ag-specific Ab responses by Treg and Tfr.

Wing JB, Lim EL, Sakaguchi S

Immunological reviews　2020/06　Research paper (scientific journal)

Clinical importance of the expression of CD4+CD8+ T cells in renal cell carcinoma.

Kentaro Nishida, Atsunari Kawashima, Takayuki Kanazawa, Yujiro Kidani, Tetsuya Yoshida, Michinari Hirata, Kei Yamamoto, Yoko Yamamoto, Masaaki Sawada, Ryo Kato, Taigo Kato, Koji Hatano, Takeshi Ujike, Kazutoshi Fujita, Motohide Uemura, Akiko Morimoto-Okazawa, Kota Iwahori, Makoto Yamasaki, Naganari Ohkura, Shimon Sakaguchi, Norio Nonomura, Yuichiro Doki, Hisashi Wada

International immunology　Vol. 32　No. 5　p. 347-357　2020/05/08　Research paper (scientific journal)

Regulatory T Cells and Human Disease

Shimon Sakaguchi, Norihisa Mikami, James B. Wing, Atsushi Tanaka, Kenji Ichiyama, Naganari Ohkura

Annual Review of Immunology　Vol. 38　No. 1　p. 541-566　2020/04/26　Research paper (scientific journal)

Tumour grade significantly correlates with total dysfunction of tumour tissue-infiltrating lymphocytes in renal cell carcinoma.

Atsunari Kawashima, Takayuki Kanazawa, Yujiro Kidani, Tetsuya Yoshida, Michinari Hirata, Kentaro Nishida, Satoshi Nojima, Yoshiyuki Yamamoto, Taigo Kato, Koji Hatano, Takeshi Ujike, Akira Nagahara, Kazutoshi Fujita, Akiko Morimoto-Okazawa, Kota Iwahori, Motohide Uemura, Ryoichi Imamura, Naganari Ohkura, Eiichi Morii, Shimon Sakaguchi, Hisashi Wada, Norio Nonomura

Scientific reports　Vol. 10　No. 1　p. 6220-6220　2020/04/10　Research paper (scientific journal)

Impaired T cell receptor signaling and development of T cell-mediated autoimmune arthritis.

Yusuke Takeuchi, Keiji Hirota, Shimon Sakaguchi

Immunological reviews　Vol. 294　No. 1　p. 164-176　2020/03

Tyrosine kinase inhibitor imatinib augments tumor immunity by depleting effector regulatory T cells.

Atsushi Tanaka, Hiroyoshi Nishikawa, Shinsuke Noguchi, Daisuke Sugiyama, Hiromasa Morikawa, Yoshiko Takeuchi, Danbee Ha, Naoya Shigeta, Toshio Kitawaki, Yuka Maeda, Takuro Saito, Yoshinori Shinohara, Yoshihiro Kameoka, Keiko Iwaisako, Fumihiko Monma, Kohshi Ohishi, Julia Karbach, Elke Jäger, Kenichi Sawada, Naoyuki Katayama, Naoto Takahashi, Shimon Sakaguchi

The Journal of experimental medicine　Vol. 217　No. 2　2020/02/03　Research paper (scientific journal)

Conversion of antigen-specific effector/memory T cells into Foxp3-expressing Treg cells by inhibition of CDK8/19.

Masahiko Akamatsu, Norihisa Mikami, Naganari Ohkura, Ryoji Kawakami, Yohko Kitagawa, Atsushi Sugimoto, Keiji Hirota, Naoto Nakamura, Satoru Ujihara, Toshio Kurosaki, Hisao Hamaguchi, Hironori Harada, Guliang Xia, Yoshiaki Morita, Ichiro Aramori, Shuh Narumiya, Shimon Sakaguchi

Science immunology　Vol. 4　No. 40　2019/10/25　Research paper (scientific journal)

Theoretical modeling reveals that regulatory T cells increase T-cell interaction with antigen-presenting cells for stable immune tolerance.

Tomoyuki Yamaguchi, Shunsuke Teraguchi, Chikara Furusawa, Hiroaki Machiyama, Tomonobu M Watanabe, Hideaki Fujita, Shimon Sakaguchi, Toshio Yanagida

International immunology　Vol. 31　No. 11　p. 743-753　2019/10/16　Research paper (scientific journal)

Dynamic Imprinting of the Treg Cell-Specific Epigenetic Signature in Developing Thymic Regulatory T Cells

Susanne Herppich, Aras Toker, Beate Pietzsch, Yohko Kitagawa, Naganari Ohkura, Takahisa Miyao, Stefan Floess, Shohei Hori, Shimon Sakaguchi, Jochen Huehn

Frontiers in Immunology　Vol. 10　2019/10/11　Research paper (scientific journal)

Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)

Andrea Cossarizza, Hyun-Dong Chang, Andreas Radbruch, Andreas Acs, Dieter Adam, Sabine Adam-Klages, William W. Agace, Nima Aghaeepour, Mübeccel Akdis, Matthieu Allez, Larissa Nogueira Almeida, Giorgia Alvisi, Graham Anderson, Immanuel Andrä, Francesco Annunziato, Achille Anselmo, Petra Bacher, Cosima T. Baldari, Sudipto Bari, Vincenzo Barnaba, Joana Barros-Martins, Luca Battistini, Wolfgang Bauer, Sabine Baumgart, Nicole Baumgarth, Dirk Baumjohann, Bianka Baying, Mary Bebawy, Burkhard Becher, Wolfgang Beisker, Vladimir Benes, Rudi Beyaert, Alfonso Blanco, Dominic A. Boardman, Christian Bogdan, Jessica G. Borger, Giovanna Borsellino, Philip E. Boulais, Jolene A. Bradford, Dirk Brenner, Ryan R. Brinkman, Anna E. S. Brooks, Dirk H. Busch, Martin Büscher, Timothy P. Bushnell, Federica Calzetti, Garth Cameron, Ilenia Cammarata, Xuetao Cao, Susanna L. Cardell, Stefano Casola, Marco A. Cassatella, Andrea Cavani, Antonio Celada, Lucienne Chatenoud, Pratip K. Chattopadhyay, Sue Chow, Eleni Christakou, Luka Čičin-Šain, Mario Clerici, Federico S. Colombo, Laura Cook, Anne Cooke, Andrea M. Cooper, Alexandra J. Corbett, Antonio Cosma, Lorenzo Cosmi, Pierre G. Coulie, Ana Cumano, Ljiljana Cvetkovic, Van Duc Dang, Chantip Dang-Heine, Martin S. Davey, Derek Davies, Sara De Biasi, Genny Del Zotto, Gelo Victoriano Dela Cruz, Michael Delacher, Silvia Della Bella, Paolo Dellabona, Günnur Deniz, Mark Dessing, James P. Di Santo, Andreas Diefenbach, Francesco Dieli, Andreas Dolf, Thomas Dörner, Regine J. Dress, Diana Dudziak, Michael Dustin, Charles-Antoine Dutertre, Friederike Ebner, Sidonia B. G. Eckle, Matthias Edinger, Pascale Eede, Götz R.A. Ehrhardt, Marcus Eich, Pablo Engel, Britta Engelhardt, Anna Erdei, Charlotte Esser, Bart Everts, Maximilien Evrard, Christine S. Falk, Todd A. Fehniger, Mar Felipo-Benavent, Helen Ferry, Markus Feuerer, Andrew Filby, Kata Filkor, Simon Fillatreau, Marie Follo, Irmgard Förster, John Foster, Gemma A. Foulds, Britta Frehse, Paul S. Frenette, Stefan Frischbutter, Wolfgang Fritzsche, David W. Galbraith, Anastasia Gangaev, Natalio Garbi, Brice Gaudilliere, Ricardo T. Gazzinelli, Jens Geginat, Wilhelm Gerner, Nicholas A. Gherardin, Kamran Ghoreschi, Lara Gibellini, Florent Ginhoux, Keisuke Goda, Dale I. Godfrey, Christoph Goettlinger, Jose M. González-Navajas, Carl S. Goodyear, Andrea Gori, Jane L. Grogan, Daryl Grummitt, Andreas Grützkau, Claudia Haftmann, Jonas Hahn, Hamida Hammad, Günter Hämmerling, Leo Hansmann, Goran Hansson, Christopher M. Harpur, Susanne Hartmann, Andrea Hauser, Anja E. Hauser, David L. Haviland, David Hedley, Daniela C. Hernández, Guadalupe Herrera, Martin Herrmann, Christoph Hess, Thomas Höfer, Petra Hoffmann, Kristin Hogquist, Tristan Holland, Thomas Höllt, Rikard Holmdahl, Pleun Hombrink, Jessica P. Houston, Bimba F. Hoyer, Bo Huang, Fang-Ping Huang, Johanna E. Huber, Jochen Huehn, Michael Hundemer, Christopher A. Hunter, William Y. K. Hwang, Anna Iannone, Florian Ingelfinger, Sabine M Ivison, Hans-Martin Jäck, Peter K. Jani, Beatriz Jávega, Stipan Jonjic, Toralf Kaiser, Tomas Kalina, Thomas Kamradt, Stefan H. E. Kaufmann, Baerbel Keller, Steven L. C. Ketelaars, Ahad Khalilnezhad, Srijit Khan, Jan Kisielow, Paul Klenerman, Jasmin Knopf, Hui-Fern Koay, Katja Kobow, Jay K. Kolls, Wan Ting Kong, Manfred Kopf, Thomas Korn, Katharina Kriegsmann, Hendy Kristyanto, Thomas Kroneis, Andreas Krueger, Jenny Kühne, Christian Kukat, Désirée Kunkel, Heike Kunze-Schumacher, Tomohiro Kurosaki, Christian Kurts, Pia Kvistborg, Immanuel Kwok, Jonathan Landry, Olivier Lantz, Paola Lanuti, Francesca LaRosa, Agnès Lehuen, Salomé LeibundGut-Landmann, Michael D. Leipold, Leslie Y.T. Leung, Megan K. Levings, Andreia C. Lino, Francesco Liotta, Virginia Litwin, Yanling Liu, Hans-Gustaf Ljunggren, Michael Lohoff, Giovanna Lombardi, Lilly Lopez, Miguel López-Botet, Amy E. Lovett-Racke, Erik Lubberts, Herve Luche, Burkhard Ludewig, Enrico Lugli, Sebastian Lunemann, Holden T. Maecker, Laura Maggi, Orla Maguire, Florian Mair, Kerstin H. Mair, Alberto Mantovani, Rudolf A. Manz, Aaron J. Marshall, Alicia Martínez-Romero, Glòria Martrus, Ivana Marventano, Wlodzimierz Maslinski, Giuseppe Matarese, Anna Vittoria Mattioli, Christian Maueröder, Alessio Mazzoni, James McCluskey, Mairi McGrath, Helen M. McGuire, Iain B. McInnes, Henrik E. Mei, Fritz Melchers, Susanne Melzer, Dirk Mielenz, Stephen D. Miller, Kingston H.G. Mills, Hans Minderman, Jenny Mjösberg, Jonni Moore, Barry Moran, Lorenzo Moretta, Tim R. Mosmann, Susann Müller, Gabriele Multhoff, Luis Enrique Muñoz, Christian Münz, Toshinori Nakayama, Milena Nasi, Katrin Neumann, Lai Guan Ng, Antonia Niedobitek, Sussan Nourshargh, Gabriel Núñez, José-Enrique O'Connor, Aaron Ochel, Anna Oja, Diana Ordonez, Alberto Orfao, Eva Orlowski-Oliver, Wenjun Ouyang, Annette Oxenius, Raghavendra Palankar, Isabel Panse, Kovit Pattanapanyasat, Malte Paulsen, Dinko Pavlinic, Livius Penter, Pärt Peterson, Christian Peth, Jordi Petriz, Federica Piancone, Winfried F. Pickl, Silvia Piconese, Marcello Pinti, A. Graham Pockley, Malgorzata Justyna Podolska, Zhiyong Poon, Katharina Pracht, Immo Prinz, Carlo E. M. Pucillo, Sally A. Quataert, Linda Quatrini, Kylie M. Quinn, Helena Radbruch, Tim R. D. J. Radstake, Susann Rahmig, Hans-Peter Rahn, Bartek Rajwa, Gevitha Ravichandran, Yotam Raz, Jonathan A. Rebhahn, Diether Recktenwald, Dorothea Reimer, Caetano Reis e Sousa, Ester B.M. Remmerswaal, Lisa Richter, Laura G. Rico, Andy Riddell, Aja M. Rieger, J. Paul Robinson, Chiara Romagnani, Anna Rubartelli, Jürgen Ruland, Armin Saalmüller, Yvan Saeys, Takashi Saito, Shimon Sakaguchi, Francisco Sala-de-Oyanguren, Yvonne Samstag, Sharon Sanderson, Inga Sandrock, Angela Santoni, Ramon Bellmàs Sanz, Marina Saresella, Catherine Sautes-Fridman, Birgit Sawitzki, Linda Schadt, Alexander Scheffold, Hans U. Scherer, Matthias Schiemann, Frank A. Schildberg, Esther Schimisky, Andreas Schlitzer, Josephine Schlosser, Stephan Schmid, Steffen Schmitt, Kilian Schober, Daniel Schraivogel, Wolfgang Schuh, Thomas Schüler, Reiner Schulte, Axel Ronald Schulz, Sebastian R. Schulz, Cristiano Scottá, Daniel Scott-Algara, David P. Sester, T. Vincent Shankey, Bruno Silva-Santos, Anna Katharina Simon, Katarzyna M. Sitnik, Silvano Sozzani, Daniel E. Speiser, Josef Spidlen, Anders Stahlberg, Alan M. Stall, Natalie Stanley, Regina Stark, Christina Stehle, Tobit Steinmetz, Hannes Stockinger, Yousuke Takahama, Kiyoshi Takeda, Leonard Tan, Attila Tárnok, Gisa Tiegs, Gergely Toldi, Julia Tornack, Elisabetta Traggiai, Mohamed Trebak, Timothy I.M. Tree, Joe Trotter, John Trowsdale, Maria Tsoumakidou, Henning Ulrich, Sophia Urbanczyk, Willem van de Veen, Maries van den Broek, Edwin van der Pol, Sofie Van Gassen, Gert Van Isterdael, René A.W. van Lier, Marc Veldhoen, Salvador Vento-Asturias, Paulo Vieira, David Voehringer, Hans-Dieter Volk, Anouk von Borstel, Konrad von Volkmann, Ari Waisman, Rachael V. Walker, Paul K. Wallace, Sa A. Wang, Xin M. Wang, Michael D. Ward, Kirsten A Ward-Hartstonge, Klaus Warnatz, Gary Warnes, Sarah Warth, Claudia Waskow, James V. Watson, Carsten Watzl, Leonie Wegener, Thomas Weisenburger, Annika Wiedemann, Jürgen Wienands, Anneke Wilharm, Robert John Wilkinson, Gerald Willimsky, James B. Wing, Rieke Winkelmann, Thomas H. Winkler, Oliver F. Wirz, Alicia Wong, Peter Wurst, Jennie H. M. Yang, Juhao Yang, Maria Yazdanbakhsh, Liping Yu, Alice Yue, Hanlin Zhang, Yi Zhao, Susanne Maria Ziegler, Christina Zielinski, Jakob Zimmermann, Arturo Zychlinsky

European Journal of Immunology　Vol. 49　No. 10　p. 1457-1973　2019/10/01　Research paper (scientific journal)

Synovial Tissue Inflammation Mediated by Autoimmune T Cells.

Takeuchi Y, Hirota K, Sakaguchi S

Frontiers in immunology　Vol. 10　2019/08

頭頸部癌における制御性T細胞の新たな特徴

的場 拓磨, 今井 優樹, 大倉 永也, 川北 大介, 伊地知 圭, 遠山 竜也, 森田 明理, 村上 信五, 坂口 志文, 山崎 小百合

耳鼻咽喉科免疫アレルギー　Vol. 37　No. 2　p. 72-73　2019/06

Strain-Specific Manifestation of Lupus-like Systemic Autoimmunity Caused by Zap70 Mutation.

Takashi Matsuo, Motomu Hashimoto, Shimon Sakaguchi, Noriko Sakaguchi, Yoshinaga Ito, Masaki Hikida, Tatsuaki Tsuruyama, Kaoru Sakai, Hideki Yokoi, Mirei Shirakashi, Masao Tanaka, Hiromu Ito, Hajime Yoshifuji, Koichiro Ohmura, Takao Fujii, Tsuneyo Mimori

Journal of immunology (Baltimore, Md. : 1950)　Vol. 202　No. 11　p. 3161-3172　2019/06/01　Research paper (scientific journal)

PD-1+ regulatory T cells amplified by PD-1 blockade promote hyperprogression of cancer

Takahiro Kamada, Yosuke Togashi, Danbee Ha, Akinori Sasaki, Yoshiaki Nakamura, Eiichi Sato, Shota Fukuoka, Yasuko Tada, Atsushi Tanaka, Akihito Kawazoe, Takahiro Kinoshita, Kohei Shitara, Shimon Sakaguchi, Hiroyoshi Nishikawa

Proc Natl Acad Sci U S A　2019/04

Satb1 regulates the effector program of encephalitogenic tissue Th17 cells in chronic inflammation.

Keiko Yasuda, Yohko Kitagawa, Ryoji Kawakami, Yoshitaka Isaka, Hitomi Watanabe, Gen Kondoh, Terumi Kohwi-Shigematsu, Shimon Sakaguchi, Keiji Hirota

Nature communications　Vol. 10　No. 1　p. 549-549　2019/02/01　Research paper (scientific journal)

Human FOXP3+ Regulatory T Cell Heterogeneity and Function in Autoimmunity and Cancer.

Wing JB, Tanaka A, Sakaguchi S

Immunity　2019/02　Research paper (scientific journal)

Preparation of Immunotolerant Space Under the Skin and Transplantation of Islets in the Space.

Rei Kuwabara, Masahide Hamaguchi, Takuya Fukuda, Shimon Sakaguchi, Hiroo Iwata

Tissue engineering. Part A　Vol. 25　No. 3-4　p. 183-192　2019/02　Research paper (scientific journal)

Differential control of human Treg and effector T cells in tumor immunity by Fc-engineered anti-CTLA-4 antibody.

Danbee Ha, Atsushi Tanaka, Tatsuya Kibayashi, Atsushi Tanemura, Daisuke Sugiyama, James Badger Wing, Ee Lyn Lim, Karen Wei Weng Teng, Dennis Adeegbe, Evan W Newell, Ichiro Katayama, Hiroyoshi Nishikawa, Shimon Sakaguchi

Proceedings of the National Academy of Sciences of the United States of America　Vol. 116　No. 2　p. 609-618　2019/01/08　Research paper (scientific journal)

Control of Regulatory T Cells by Co-signal Molecules.

James Badger Wing, Christopher Tay, Shimon Sakaguchi

Advances in experimental medicine and biology　Vol. 1189　p. 179-210　2019　Research paper (scientific journal)

Loss of TET proteins in regulatory T cells promotes abnormal proliferation, Foxp3 destabilization and IL-17 expression

Hiroko Nakatsukasa, Mayumi Oda, Jinghua Yin, Shunsuke Chikuma, Minako Ito, Mana Koga-Iizuka, Kazue Someya, Yohko Kitagawa, Naganari Ohkura, Shimon Sakaguchi, Ikuko Koya, Tsukasa Sanosaka, Jun Kohyama, Yu Ichi Tsukada, Soichiro Yamanaka, Takeji Takamura-Enya, Qianjin Lu, Akihiko Yoshimura

International Immunology　Vol. 31　No. 5　p. 335-347　2019　Research paper (scientific journal)

Innate Myeloid Cell Subset-Specific Gene Expression Patterns in the Human Colon are Altered in Crohn's Disease Patients.

Yuki Sekido, Yoshiaki Yasumizu, Junichi Nishimura, Hisako Kayama, Hiroshi Matsuno, Takayuki Ogino, Norikatsu Miyoshi, Hidekazu Takahashi, Naotsugu Haraguchi, Taishi Hata, Chu Matsuda, Yuichiro Doki, Masaki Mori, Kiyoshi Takeda, Naganari Ohkura, Shimon Sakaguchi, Tsunekazu Mizushima

Digestion　Vol. 99　No. 3　p. 194-204　2019　Research paper (scientific journal)

Are naïve T cells and class-switched memory (IgD − CD27 + ) B cells not essential for establishment and maintenance of pregnancy? Insights from a case of common variable immunodeficiency with pregnancy

Naoya Shigeta, Hitomi Nakamura, Keiichi Kumasawa, Kohsuke Imai, Shigeru Saito, Shimon Sakaguchi, Tadashi Kimura

Medical Hypotheses　Vol. 121　p. 36-41　2018/12/01　Research paper (scientific journal)

Regulatory T cells expressing abundant CTLA-4 on the cell surface with a proliferative gene profile are key features of human head and neck cancer.

Matoba T, Imai M, Ohkura N, Kawakita D, Ijichi K, Toyama T, Morita A, Murakami S, Sakaguchi S, Yamazaki S

International journal of cancer　Vol. 144　No. 11　p. 2811-2822　2018/11　Research paper (scientific journal)

Nod2 deficiency augments Th17 responses and exacerbates autoimmune arthritis

Ruth J. Napier, Ellen J. Lee, Emily E. Vance, Paige E. Snow, Kimberly A. Samson, Clare E. Dawson, Amy E. Moran, Peter Stenzel, Michael P. Davey, Shimon Sakaguchi, Holly L. Rosenzweig

Journal of Immunology　Vol. 201　No. 7　p. 1889-1898　2018/10/01　Research paper (scientific journal)

Control of Germinal Center Responses by T-Follicular Regulatory Cells.

Wing JB, Tekgüç M, Sakaguchi S

Frontiers in immunology　2018/08　Research paper (scientific journal)

Autoimmune Th17 Cells Induced Synovial Stromal and Innate Lymphoid Cell Secretion of the Cytokine GM-CSF to Initiate and Augment Autoimmune Arthritis.

Keiji Hirota, Motomu Hashimoto, Yoshinaga Ito, Mayumi Matsuura, Hiromu Ito, Masao Tanaka, Hitomi Watanabe, Gen Kondoh, Atsushi Tanaka, Keiko Yasuda, Manfred Kopf, Alexandre J Potocnik, Brigitta Stockinger, Noriko Sakaguchi, Shimon Sakaguchi

Immunity　Vol. 48　No. 6　p. 1220-1232　2018/06/19　Research paper (scientific journal)

Preoperative metabolic tumor volume of intrahepatic cholangiocarcinoma measured by 18F-FDG-PET is associated with the KRAS mutation status and prognosis

Yoshinobu Ikeno, Satoru Seo, Keiko Iwaisako, Tomoaki Yoh, Yuji Nakamoto, Hiroaki Fuji, Kojiro Taura, Hideaki Okajima, Toshimi Kaido, Shimon Sakaguchi, Shinji Uemoto

Journal of Translational Medicine　Vol. 16　No. 1　2018/04/11　Research paper (scientific journal)

Selective cell capture and release using antibody-immobilized polymer-grafted surface

Tsuyoshi Kimura, Naoko Nakamura, Yoshihide Hashimoto, Shimon Sakaguchi, Shunsaku Kimura, Akio Kishida

Kobunshi Ronbunshu　Vol. 75　No. 2　p. 155-163　2018/03/01　Research paper (scientific journal)

Long-term Functioning of Allogeneic Islets in Subcutaneous Tissue Pretreated with a Novel Cyclic Peptide Without Immunosuppressive Medication

Rei Kuwabara, Masahide Hamaguchi, Takuya Fukuda, Hiroki Sakai, Makoto Inui, Shimon Sakaguchi, Hiroo Iwata

Transplantation　Vol. 102　No. 3　p. 417-425　2018/03/01　Research paper (scientific journal)

Minimum information about T regulatory cells: A step toward reproducibility and standardization

Anke Fuchs, Mateusz Gliwinski, Nathali Grageda, Rachel Spiering, Abul K. Abbas, Silke Appel, Rosa Bacchetta, Manuela Battaglia, David Berglund, Bruce Blazar, Jeffrey A. Bluestone, Martin Bornhäuser, Anja ten Brinke, Todd M. Brusko, Nathalie Cools, Maria Cristina Cuturi, Edward Geissler, Nick Giannoukakis, Karolina Golab, David A. Hafler, S. Marieke van Ham, Joanna Hester, Keli Hippen, Mauro Di Ianni, Natasa Ilic, John Isaacs, Fadi Issa, Dorota Iwaszkiewicz-Grzes, Elmar Jaeckel, Irma Joosten, David Klatzmann, Hans Koenen, Cees van Kooten, Olle Korsgren, Karsten Kretschmer, Megan Levings, Natalia Maria Marek-Trzonkowska, Marc Martinez-Llordella, Djordje Miljkovic, Kingston H.G. Mills, Joana P. Miranda, Ciriaco A. Piccirillo, Amy L. Putnam, Thomas Ritter, Maria Grazia Roncarolo, Shimon Sakaguchi, Silvia Sánchez-Ramón, Birgit Sawitzki, Ljiljana Sofronic-Milosavljevic, Megan Sykes, Qizhi Tang, Marta Vives-Pi, Herman Waldmann, Piotr Witkowski, Kathryn J. Wood, Silvia Gregori, Catharien M.U. Hilkens, Giovanna Lombardi, Phillip Lord, Eva M. Martinez-Caceres, Piotr Trzonkowski

Frontiers in Immunology　Vol. 8　2018/01/15　Research paper (scientific journal)

Slc3a2 Mediates Branched-Chain Amino-Acid-Dependent Maintenance of Regulatory T Cells

Kayo Ikeda, Makoto Kinoshita, Hisako Kayama, Shushi Nagamori, Pornparn Kongpracha, Eiji Umemoto, Ryu Okumura, Takashi Kurakawa, Mari Murakami, Norihisa Mikami, Yasunori Shintani, Satoko Ueno, Ayatoshi Andou, Morihiro Ito, Hideki Tsumura, Koji Yasutomo, Keiichi Ozono, Seiji Takashima, Shimon Sakaguchi, Yoshikatsu Kanai, Kiyoshi Takeda

Cell Reports　Vol. 21　No. 7　p. 1824-1838　2017/11/14　Research paper (scientific journal)

抗体固定化フィルターによる免疫細胞の捕集

木村 剛, 中村 奈緒子, 橋本 良秀, 坂口 志文, 木村 俊作, 岸田 晶夫

日本バイオマテリアル学会大会予稿集　Vol. 39回　p. 217-217　2017/11

Guidance of regulatory T cell development by Satb1-dependent super-enhancer establishment (vol 18, pg 173, 2017)

Yohko Kitagawa, Naganari Ohkura, Yujiro Kidani, Alexis Vandenbon, Keiji Hirota, Ryoji Kawakami, Keiko Yasuda, Daisuke Motooka, Shota Nakamura, Motonari Kondo, Ichiro Taniuchi, Terumi Kohwi-Shigematsu, Shimon Sakaguchi

NATURE IMMUNOLOGY　Vol. 18　No. 11　p. 1270-1270　2017/11

Guidelines for the use of flow cytometry and cell sorting in immunological studies

Andrea Cossarizza, Hyun-Dong Chang, Andreas Radbruch, Mübeccel Akdis, Immanuel Andrä, Francesco Annunziato, Petra Bacher, Vincenzo Barnaba, Luca Battistini, Wolfgang M. Bauer, Sabine Baumgart, Burkhard Becher, Wolfgang Beisker, Claudia Berek, Alfonso Blanco, Giovanna Borsellino, Philip E. Boulais, Ryan R. Brinkman, Martin Büscher, Dirk H. Busch, Timothy P. Bushnell, Xuetao Cao, Andrea Cavani, Pratip K. Chattopadhyay, Qingyu Cheng, Sue Chow, Mario Clerici, Anne Cooke, Antonio Cosma, Lorenzo Cosmi, Ana Cumano, Van Duc Dang, Derek Davies, Sara De Biasi, Genny Del Zotto, Silvia Della Bella, Paolo Dellabona, Günnur Deniz, Mark Dessing, Andreas Diefenbach, James Di Santo, Francesco Dieli, Andreas Dolf, Vera S. Donnenberg, Thomas Dörner, Götz R. A. Ehrhardt, Elmar Endl, Pablo Engel, Britta Engelhardt, Charlotte Esser, Bart Everts, Anita Dreher, Christine S. Falk, Todd A. Fehniger, Andrew Filby, Simon Fillatreau, Marie Follo, Irmgard Förster, John Foster, Gemma A. Foulds, Paul S. Frenette, David Galbraith, Natalio Garbi, Maria Dolores García-Godoy, Jens Geginat, Kamran Ghoreschi, Lara Gibellini, Christoph Goettlinger, Carl S. Goodyear, Andrea Gori, Jane Grogan, Mor Gross, Andreas Grützkau, Daryl Grummitt, Jonas Hahn, Quirin Hammer, Anja E. Hauser, David L. Haviland, David Hedley, Guadalupe Herrera, Martin Herrmann, Falk Hiepe, Tristan Holland, Pleun Hombrink, Jessica P. Houston, Bimba F. Hoyer, Bo Huang, Christopher A. Hunter, Anna Iannone, Hans-Martin Jäck, Beatriz Jávega, Stipan Jonjic, Kerstin Juelke, Steffen Jung, Toralf Kaiser, Tomas Kalina, Baerbel Keller, Srijit Khan, Deborah Kienhöfer, Thomas Kroneis, Désirée Kunkel, Christian Kurts, Pia Kvistborg, Joanne Lannigan, Olivier Lantz, Anis Larbi, Salome LeibundGut-Landmann, Michael D. Leipold, Megan K. Levings, Virginia Litwin, Yanling Liu, Michael Lohoff, Giovanna Lombardi, Lilly Lopez, Amy Lovett-Racke, Erik Lubberts, Burkhard Ludewig, Enrico Lugli, Holden T. Maecker, Glòria Martrus, Giuseppe Matarese, Christian Maueröder, Mairi McGrath, Iain McInnes, Henrik E. Mei, Fritz Melchers, Susanne Melzer, Dirk Mielenz, Kingston Mills, David Mirrer, Jenny Mjösberg, Jonni Moore, Barry Moran, Alessandro Moretta, Lorenzo Moretta, Tim R. Mosmann, Susann Müller, Werner Müller, Christian Münz, Gabriele Multhoff, Luis Enrique Munoz, Kenneth M. Murphy, Toshinori Nakayama, Milena Nasi, Christine Neudörfl, John Nolan, Sussan Nourshargh, José-Enrique O'Connor, Wenjun Ouyang, Annette Oxenius, Raghav Palankar, Isabel Panse, Pärt Peterson, Christian Peth, Jordi Petriz, Daisy Philips, Winfried Pickl, Silvia Piconese, Marcello Pinti, A. Graham Pockley, Malgorzata Justyna Podolska, Carlo Pucillo, Sally A. Quataert, Timothy R. D. J. Radstake, Bartek Rajwa, Jonathan A. Rebhahn, Diether Recktenwald, Ester B.M. Remmerswaal, Katy Rezvani, Laura G. Rico, J. Paul Robinson, Chiara Romagnani, Anna Rubartelli, Beate Ruckert, Jürgen Ruland, Shimon Sakaguchi, Francisco Sala-de-Oyanguren, Yvonne Samstag, Sharon Sanderson, Birgit Sawitzki, Alexander Scheffold, Matthias Schiemann, Frank Schildberg, Esther Schimisky, Stephan A. Schmid, Steffen Schmitt, Kilian Schober, Thomas Schüler, Axel Ronald Schulz, Ton Schumacher, Cristiano Scotta, T. Vincent Shankey, Anat Shemer, Anna-Katharina Simon, Josef Spidlen, Alan M. Stall, Regina Stark, Christina Stehle, Merle Stein, Tobit Steinmetz, Hannes Stockinger, Yousuke Takahama, Attila Tarnok, ZhiGang Tian, Gergely Toldi, Julia Tornack, Elisabetta Traggiai, Joe Trotter, Henning Ulrich, Marlous van der Braber, René A. W. van Lier, Marcello Veldhoen, Salvador Vento-Asturias, Paulo Vieira, David Voehringer, Hans-Dieter Volk, Konrad von Volkmann, Ari Waisman, Rachael Walker, Michael D. Ward, Klaus Warnatz, Sarah Warth, James V. Watson, Carsten Watzl, Leonie Wegener, Annika Wiedemann, Jürgen Wienands, Gerald Willimsky, James Wing, Peter Wurst, Liping Yu, Alice Yue, Qianjun Zhang, Yi Zhao, Susanne Ziegler, Jakob Zimmermann

European Journal of Immunology　Vol. 47　No. 10　p. 1584-1797　2017/10/01　Research paper (scientific journal)

Lamtor1 Is Critically Required for CD4(+) T Cell Proliferation and Regulatory T Cell Suppressive Function

Takashi Hosokawa, Tetsuya Kimura, Shigeyuki Nada, Tatsusada Okuno, Daisuke Ito, Sujin Kang, Satoshi Nojima, Kazuya Yamashita, Takeshi Nakatani, Yoshitomo Hayama, Yasuhiro Kato, Yuhei Kinehara, Masayuki Nishide, Norihisa Mikami, Syohei Koyama, Hyota Takamatsu, Daisuke Okuzaki, Naganari Ohkura, Shimon Sakaguchi, Masato Okada, Atsushi Kumanogoh

JOURNAL OF IMMUNOLOGY　Vol. 199　No. 6　p. 2008-2019　2017/09　Research paper (scientific journal)

FANTOM5 CAGE profiles of human and mouse samples.

Shuhei Noguchi, Takahiro Arakawa, Shiro Fukuda, Masaaki Furuno, Akira Hasegawa, Fumi Hori, Sachi Ishikawa-Kato, Kaoru Kaida, Ai Kaiho, Mutsumi Kanamori-Katayama, Tsugumi Kawashima, Miki Kojima, Atsutaka Kubosaki, Ri-Ichiroh Manabe, Mitsuyoshi Murata, Sayaka Nagao-Sato, Kenichi Nakazato, Noriko Ninomiya, Hiromi Nishiyori-Sueki, Shohei Noma, Eri Saijyo, Akiko Saka, Mizuho Sakai, Christophe Simon, Naoko Suzuki, Michihira Tagami, Shoko Watanabe, Shigehiro Yoshida, Peter Arner, Richard A Axton, Magda Babina, J Kenneth Baillie, Timothy C Barnett, Anthony G Beckhouse, Antje Blumenthal, Beatrice Bodega, Alessandro Bonetti, James Briggs, Frank Brombacher, Ailsa J Carlisle, Hans C Clevers, Carrie A Davis, Michael Detmar, Taeko Dohi, Albert S B Edge, Matthias Edinger, Anna Ehrlund, Karl Ekwall, Mitsuhiro Endoh, Hideki Enomoto, Afsaneh Eslami, Michela Fagiolini, Lynsey Fairbairn, Mary C Farach-Carson, Geoffrey J Faulkner, Carmelo Ferrai, Malcolm E Fisher, Lesley M Forrester, Rie Fujita, Jun-Ichi Furusawa, Teunis B Geijtenbeek, Thomas Gingeras, Daniel Goldowitz, Sven Guhl, Reto Guler, Stefano Gustincich, Thomas J Ha, Masahide Hamaguchi, Mitsuko Hara, Yuki Hasegawa, Meenhard Herlyn, Peter Heutink, Kelly J Hitchens, David A Hume, Tomokatsu Ikawa, Yuri Ishizu, Chieko Kai, Hiroshi Kawamoto, Yuki I Kawamura, Judith S Kempfle, Tony J Kenna, Juha Kere, Levon M Khachigian, Toshio Kitamura, Sarah Klein, S Peter Klinken, Alan J Knox, Soichi Kojima, Haruhiko Koseki, Shigeo Koyasu, Weonju Lee, Andreas Lennartsson, Alan Mackay-Sim, Niklas Mejhert, Yosuke Mizuno, Hiromasa Morikawa, Mitsuru Morimoto, Kazuyo Moro, Kelly J Morris, Hozumi Motohashi, Christine L Mummery, Yutaka Nakachi, Fumio Nakahara, Toshiyuki Nakamura, Yukio Nakamura, Tadasuke Nozaki, Soichi Ogishima, Naganari Ohkura, Hiroshi Ohno, Mitsuhiro Ohshima, Mariko Okada-Hatakeyama, Yasushi Okazaki, Valerio Orlando, Dmitry A Ovchinnikov, Robert Passier, Margaret Patrikakis, Ana Pombo, Swati Pradhan-Bhatt, Xian-Yang Qin, Michael Rehli, Patrizia Rizzu, Sugata Roy, Antti Sajantila, Shimon Sakaguchi, Hiroki Sato, Hironori Satoh, Suzana Savvi, Alka Saxena, Christian Schmidl, Claudio Schneider, Gundula G Schulze-Tanzil, Anita Schwegmann, Guojun Sheng, Jay W Shin, Daisuke Sugiyama, Takaaki Sugiyama, Kim M Summers, Naoko Takahashi, Jun Takai, Hiroshi Tanaka, Hideki Tatsukawa, Andru Tomoiu, Hiroo Toyoda, Marc van de Wetering, Linda M van den Berg, Roberto Verardo, Dipti Vijayan, Christine A Wells, Louise N Winteringham, Ernst Wolvetang, Yoko Yamaguchi, Masayuki Yamamoto, Chiyo Yanagi-Mizuochi, Misako Yoneda, Yohei Yonekura, Peter G Zhang, Silvia Zucchelli, Imad Abugessaisa, Erik Arner, Jayson Harshbarger, Atsushi Kondo, Timo Lassmann, Marina Lizio, Serkan Sahin, Thierry Sengstag, Jessica Severin, Hisashi Shimoji, Masanori Suzuki, Harukazu Suzuki, Jun Kawai, Naoto Kondo, Masayoshi Itoh, Carsten O Daub, Takeya Kasukawa, Hideya Kawaji, Piero Carninci, Alistair R R Forrest, Yoshihide Hayashizaki

Scientific data　Vol. 4　p. 170112-170112　2017/08/29　Research paper (scientific journal)

A distinct subpopulation of CD25− T-follicular regulatory cells localizes in the germinal centers

James Badger Wing, Yohko Kitagawa, Michela Locci, Hannah Hume, Christopher Tay, Takayoshi Morita, Yujiro Kidani, Kyoko Matsuda, Takeshi Inoue, Tomohiro Kurosaki, Shane Crotty, Cevayir Coban, Naganari Ohkura, Shimon Sakaguchi

Proceedings of the National Academy of Sciences of the United States of America　Vol. 114　No. 31　p. E6400-E6409　2017/08/01　Research paper (scientific journal)

Systemic activation of NRF2 alleviates lethal autoimmune inflammation in scurfy mice

Takuma Suzuki, Shohei Murakami, Shyam S. Biswal, Shimon Sakaguchi, Hideo Harigae, Masayuki Yamamoto, Hozumi Motohashi

Molecular and Cellular Biology　Vol. 37　No. 15　2017/08/01　Research paper (scientific journal)

Novel interferon-γ enzyme-linked immunoSpot assay using activated cells for identifying hypersensitivity-inducing drug culprits

Kenichi Kato, Asami Kawase, Hiroaki Azukizawa, Takaaki Hanafusa, Yukinobu Nakagawa, Hiroyuki Murota, Shimon Sakaguchi, Hideo Asada, Ichiro Katayama

Journal of Dermatological Science　Vol. 86　No. 3　p. 222-229　2017/06/01　Research paper (scientific journal)

Reciprocal regulation of the Il9 locus by counteracting activities of transcription factors IRF1 and IRF4

Lucia Campos Carrascosa, Matthias Klein, Yohko Kitagawa, Christina Lückel, Federico Marini, Anika König, Anna Guralnik, Hartmann Raifer, Stefanie Hagner-Benes, Diana Rädler, Andreas Böck, Cholho Kang, Michael Lohoff, Holger Garn, Bianca Schaub, Friederike Berberich-Siebelt, Shimon Sakaguchi, Tobias Bopp, Magdalena Huber

Nature Communications　Vol. 8　2017/05/12　Research paper (scientific journal)

Essential Roles of SATB1 in Specifying T Lymphocyte Subsets

Kiyokazu Kakugawa, Satoshi Kojo, Hirokazu Tanaka, Wooseok Seo, Takaho A. Endo, Yohko Kitagawa, Sawako Muroi, Mari Tenno, Nighat Yasmin, Yoshinori Kohwi, Shimon Sakaguchi, Terumi Kowhi-Shigematsu, Ichiro Taniuchi

Cell Reports　Vol. 19　No. 6　p. 1176-1188　2017/05/09　Research paper (scientific journal)

Unique properties of thymic antigen-presenting cells promote epigenetic imprinting of alloantigen-specific regulatory T cells

Garima Garg, Eirini Nikolouli, Matthias Hardtke-Wolenski, Aras Toker, Naganari Ohkura, Michael Beckstette, Takahisa Miyao, Robert Geffers, Stefan Floess, Norbert Gerdes, Esther Lutgens, Anke Osterloh, Shohei Hori, Shimon Sakaguchi, Elmar Jaeckel, Jochen Huehn

ONCOTARGET　Vol. 8　No. 22　p. 35542-35557　2017/05　Research paper (scientific journal)

Erratum: Guidance of regulatory T cell development by Satb1-dependent super-enhancer establishment

Yohko Kitagawa, Naganari Ohkura, Yujiro Kidani, Alexis Vandenbon, Keiji Hirota, Ryoji Kawakami, Keiko Yasuda, Daisuke Motooka, Shota Nakamura, Motonari Kondo, Ichiro Taniuchi, Terumi Kohwi-Shigematsu, Shimon Sakaguchi

Nature immunology　Vol. 18　No. 4　2017/03/22　Research paper (scientific journal)

T Regulatory Cells Support Plasma Cell Populations in the Bone Marrow

Arielle Glatman Zaretsky, Christoph Konradt, Fabien Dépis, James B. Wing, Radhika Goenka, Daniela Gomez Atria, Jonathan S. Silver, Sunglim Cho, Amaya I. Wolf, William J. Quinn, Julie B. Engiles, Dorothy C. Brown, Daniel Beiting, Jan Erikson, David Allman, Michael P. Cancro, Shimon Sakaguchi, Li-Fan Lu, Christophe O. Benoist, Christopher A. Hunter

Cell Reports　Vol. 18　No. 8　p. 1906-1916　2017/02/21　Research paper (scientific journal)

Guidance of regulatory T cell development by Satb1-dependent super-enhancer establishment

Yohko Kitagawa, Naganari Ohkura, Yujiro Kidani, Alexis Vandenbon, Keiji Hirota, Ryoji Kawakami, Keiko Yasuda, Daisuke Motooka, Shota Nakamura, Motonari Kondo, Ichiro Taniuchi, Terumi Kohwi-Shigematsu, Shimon Sakaguchi

Nature Immunology　Vol. 18　No. 2　p. 173-183　2017/02/01　Research paper (scientific journal)

ICOS+ Foxp3+ TILs in gastric cancer are prognostic markers and effector regulatory T cells associated with Helicobacter pylori

Hirotsugu Nagase, Tomohira Takeoka, Shinya Urakawa, Akiko Morimoto-Okazawa, Atsunari Kawashima, Kota Iwahori, Shuji Takiguchi, Hiroyoshi Nishikawa, Eiichi Sato, Shimon Sakaguchi, Masaki Mori, Yuichiro Doki, Hisashi Wada

International Journal of Cancer　Vol. 140　No. 3　p. 686-695　2017/02/01　Research paper (scientific journal)

Control of Regulatory T Cell Development by the Transcription Factor Foxp3

Shohei Hori, Takashi Nomura, Shimon Sakaguchi

JOURNAL OF IMMUNOLOGY　Vol. 198　No. 3　p. 981-985　2017/02　Research paper (scientific journal)

Combination of IL-2, rapamycin, DNA methyltransferase and histone deacetylase inhibitors for the expansion of human regulatory T cells

Makoto Miyara, Driss Chader, Aude Burlion, Jérémie Goldstein, Delphine Sterlin, Françoise Norol, Hélène Trebeden-Nègre, Laetitia Claër, Shimon Sakaguchi, Gilles Marodon, Zahir Amoura, Guy Gorochov

Oncotarget　Vol. 8　No. 62　p. 104733-104744　2017　Research paper (scientific journal)

UVB exposure prevents atherosclerosis by regulating immunoinflammatory responses

Naoto Sasaki, Tomoya Yamashita, Kazuyuki Kasahara, Atsushi Fukunaga, Tomoyuki Yamaguchi, Takuo Emoto, Keiko Yodoi, Takuya Matsumoto, Kenji Nakajima, Tomoyuki Kita, Masafumi Takeda, Taiji Mizoguchi, Tomohiro Hayashi, Yoshihiro Sasaki, Mayumi Hatakeyama, Kumiko Taguchi, Ken Washio, Shimon Sakaguchi, Bernard Malissen, Chikako Nishigori, Ken-Ichi Hirata

Arteriosclerosis, Thrombosis, and Vascular Biology　Vol. 37　No. 1　p. 66-74　2017/01/01　Research paper (scientific journal)

Egr2 and Egr3 in regulatory T cells cooperatively control systemic autoimmunity through Ltbp3-mediated TGF-β3 production

Kaoru Morita, Tomohisa Okamura, Mariko Inoue, Toshihiko Komai, Shuzo Teruya, Yukiko Iwasaki, Shuji Sumitomo, Hirofumi Shoda, Kazuhiko Yamamoto, Keishi Fujio, Shimon Sakaguchi

Proceedings of the National Academy of Sciences of the United States of America　Vol. 113　No. 50　p. E8131-E8140　2016/12/13　Research paper (international conference proceedings)

Identification of Novel and Noninvasive Biomarkers of Acute Cellular Rejection After Liver Transplantation by Protein Microarray.

Keita Okubo, Hiroshi Wada, Atsushi Tanaka, Hidetoshi Eguchi, Masahide Hamaguchi, Akira Tomokuni, Yoshito Tomimaru, Tadafumi Asaoka, Naoki Hama, Koichi Kawamoto, Shogo Kobayashi, Shigeru Marubashi, Hiroaki Nagano, Noriko Sakaguchi, Hiroyoshi Nishikawa, Yuichiro Doki, Masaki Mori, Shimon Sakaguchi

Transplantation direct　Vol. 2　No. 12　2016/12　Research paper (scientific journal)

機能性バイオインターフェイスの新潮流 免疫細胞分離のバイオインターフェイス開発

木村 剛, 中村 奈緒子, 橋本 良秀, 坂口 志文, 木村 俊作, 岸田 晶夫

日本バイオマテリアル学会大会予稿集　Vol. シンポジウム2016　p. 181-181　2016/11

Dysbiosis Contributes to Arthritis Development via Activation of Autoreactive T Cells in the Intestine

Yuichi Maeda, Takashi Kurakawa, Eiji Umemoto, Daisuke Motooka, Yoshinaga Ito, Kazuyoshi Gotoh, Keiji Hirota, Masato Matsushita, Yoki Furuta, Masashi Narazaki, Noriko Sakaguchi, Hisako Kayama, Shota Nakamura, Tetsuya Iida, Yukihiko Saeki, Atsushi Kumanogoh, Shimon Sakaguchi, Kiyoshi Takeda

ARTHRITIS & RHEUMATOLOGY　Vol. 68　No. 11　p. 2646-2661　2016/11　Research paper (scientific journal)

The proportion of regulatory T cells in patients with rheumatoid arthritis: A meta-Analysis

Takayoshi Morita, Yoshihito Shima, James Badger Wing, Shimon Sakaguchi, Atsushi Ogata, Atsushi Kumanogoh

PLoS ONE　Vol. 11　No. 9　2016/09/01　Research paper (scientific journal)

Antibody to CMRF35-like molecule 2, CD300e a novel biomarker detected in patients with fulminant type 1 diabetes

Fumitaka Haseda, Akihisa Imagawa, Hiroyoshi Nishikawa, Shinobu Mitsui, Chiharu Tsutsumi, Reiko Fujisawa, Hiroyuki Sano, Yuko Murase-Mishiba, Jungo Terasaki, Shimon Sakaguchi, Toshiaki Hanafusa

PLoS ONE　Vol. 11　No. 8　2016/08/01　Research paper (scientific journal)

Effector Regulatory T Cells Reflect the Equilibrium between Antitumor Immunity and Autoimmunity in Adult T-cell Leukemia

Hiroshi Ureshino, Takero Shindo, Hiroyoshi Nishikawa, Nobukazu Watanabe, Eri Watanabe, Natsuko Satoh, Kazutaka Kitaura, Hiroaki Kitamura, Kazuko Doi, Kotaro Nagase, Hiromi Kimura, Makoto Samukawa, Susumu Kusunoki, Masaharu Miyahara, Tadasu Shin-, Ryuji Suzuki, Shimon Sakaguchi, Shinya Kimura

CANCER IMMUNOLOGY RESEARCH　Vol. 4　No. 8　p. 644-649　2016/08　Research paper (scientific journal)

Loss of the Protein Tyrosine Phosphatase PTPN22 Reduces Mannan-Induced Autoimmune Arthritis in SKG Mice

Shatakshi Sood, Rebecca J. Brownlie, Celine Garcia, Graeme Cowan, Robert J. Salmond, Shimon Sakaguchi, Rose Zamoyska

JOURNAL OF IMMUNOLOGY　Vol. 197　No. 2　p. 429-440　2016/07　Research paper (scientific journal)

Two FOXP3(+)CD4(+) T cell subpopulations distinctly control the prognosis of colorectal cancers.

Takuro Saito, Hiroyoshi Nishikawa, Hisashi Wada, Yuji Nagano, Daisuke Sugiyama, Koji Atarashi, Yuka Maeda, Masahide Hamaguchi, Naganari Ohkura, Eiichi Sato, Hirotsugu Nagase, Junichi Nishimura, Hirofumi Yamamoto, Shuji Takiguchi, Takeshi Tanoue, Wataru Suda, Hidetoshi Morita, Masahira Hattori, Kenya Honda, Masaki Mori, Yuichiro Doki, Shimon Sakaguchi

Nature medicine　Vol. 22　No. 6　p. 679-84　2016/06　Research paper (scientific journal)

Utility of CD127 combined with FOXP3 for identification of operational tolerance after liver transplantation

Hanaa Nafady-Hego, Ying Li, Hidenori Ohe, Hamed Elgendy, Xiangdong Zhao, Shimon Sakaguchi, G. Alex Bishop, Takaaki Koshiba

Transplant Immunology　Vol. 36　p. 1-8　2016/05/01　Research paper (scientific journal)

Development of Regulatory T Cells in the Thymus

Yohko Kitagawa, Shimon Sakaguchi

Encyclopedia of Immunobiology　Vol. 1　p. 268-274　2016/04/27　Part of collection (book)

Treg Cells

James Badger Wing, Shimon Sakaguchi

Encyclopedia of Immunobiology　Vol. 3　p. 319-324　2016/04/27　Part of collection (book)

Immuno-Navigator, a batch-corrected coexpression database, reveals cell type-specific gene networks in the immune system

Alexis Vandenbon, Viet H. Dinh, Norihisa Mikami, Yohko Kitagawa, Shunsuke Teraguchi, Naganari Ohkura, Shimon Sakaguchi

Proceedings of the National Academy of Sciences of the United States of America　Vol. 113　No. 17　p. E2393-2402　2016/04/26　Research paper (scientific journal)

Induction of autoimmune disease by deletion of CTLA-4 in mice in adulthood

Katrin Klocke, Shimon Sakaguchi, Rikard Holmdahl, Kajsa Wing

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　Vol. 113　No. 17　p. E2383-E2392　2016/04　Research paper (scientific journal)

Hypomethylation of the Treg-Specific Demethylated Region in FOXP3 Is a Hallmark of the Regulatory T-cell Subtype in Adult T-cell Leukemia

Yayoi Shimazu, Yutaka Shimazu, Masakatsu Hishizawa, Masahide Hamaguchi, Yuya Nagai, Noriko Sugino, Sumie Fujii, Masahiro Kawahara, Norimitsu Kadowaki, Hiroyoshi Nishikawa, Shimon Sakaguchi, Akifumi Takaori-Kondo

CANCER IMMUNOLOGY RESEARCH　Vol. 4　No. 2　p. 136-145　2016/02　Research paper (scientific journal)

P1-06 TCR signalの異常とループス

松尾 崇史, 橋本 求, 疋田 正喜, 坂井 薫, 横井 秀基, 伊藤 能永, 森 将人, 藤井 隆夫, 坂口 志文, 三森 経世

日本臨床免疫学会会誌　Vol. 39　No. 4　p. 377b-377b　2016

Capture and release of target cells using a surface that immobilizes an antibody via desthiobiotin-avidin interaction

Tsuyoshi Kimura, Naoko Nakamura, Nao Sasaki, Yoshihide Hashimoto, Shimon Sakaguchi, Shunsaku Kimura, Akio Kishida

Sensors and Materials　Vol. 28　No. 12　p. 1255-1263　2016　Research paper (scientific journal)

標的細胞特異的な細胞捕集システムの開発

木村 剛, 中村 奈緒子, 佐々木 直, 坂口 志文, 木村 俊作, 岸田 晶夫

日本バイオマテリアル学会大会予稿集　Vol. 37回　p. 250-250　2015/11

The microbiota regulates type 2 immunity through RORγt<sup>+</sup> T cells

Caspar Ohnmacht, Joo-Hong Park, Sascha Cording, James B. Wing, Koji Atarashi, Yuuki Obata, Valérie Gaboriau-Routhiau, Rute Marques, Sophie Dulauroy, Maria Fedoseeva, Meinrad Busslinger, Nadine Cerf-Bensussan, Ivo G. Boneca, David Voehringer, Koji Hase, Kenya Honda, Shimon Sakaguchi, Gérard Eberl

Science　Vol. 349　No. 6251　p. 989-993　2015/08/28　Research paper (scientific journal)

Investigation of the relationship between the onset of arthritis and uveitis in genetically predisposed SKG mice

Ellen J. Lee, Emily E. Vance, Brieanna R. Brown, Paige S. Snow, Jenna S. Clowers, Shimon Sakaguchi, Holly L. Rosenzweig

Arthritis Research and Therapy　Vol. 17　No. 1　2015/08/19　Research paper (scientific journal)

Sialyl Lewis x (CD15s) identifies highly differentiated and most suppressive FOXP3<sup>high</sup> regulatory T cells in humans

Makoto Miyara, Driss Chader, Edouard Sage, Daisuke Sugiyama, Hiroyoshi Nishikawa, Diane Bouvry, Laetitia Claër, Ravi Hingorani, Robert Balderas, Jurg Rohrer, Noel Warner, Alain Chapelier, Dominique Valeyre, Reiji Kannagi, Shimon Sakaguchi, Zahir Amoura, Guy Gorochov

Proceedings of the National Academy of Sciences of the United States of America　Vol. 112　No. 23　p. 7225-7230　2015/06/09　Research paper (scientific journal)

Early life aire: The development of particulart cells at a specific time prevents autoimmunity

Atsushi Tanaka, Shimon Sakaguchi

Science　Vol. 348　No. 6234　p. 506-507　2015/05/01　Research paper (scientific journal)

In vivo induction of T-follicular helper cells by modulation of regulatory T cell function

James Badger Wing, Shimon Sakaguchi

T Follicular Helper Cells: Methods and Protocols　p. 77-85　2015/04/02　Part of collection (book)

P4-003 紫外線（UVB）照射による動脈硬化抑制効果の検討

佐々木 直人, 山下 智也, 福永 淳, 山口 智之, 坂口 志文, 錦織 千佳子, 平田 健一

日本臨床免疫学会会誌　Vol. 38　No. 4　p. 330a-330a　2015

Transcriptional and Epigenetic Control of Regulatory T Cell Development

Yohko Kitagawa, James Badger Wing, Shimon Sakaguchi

Progress in Molecular Biology and Translational Science　Vol. 136　p. 1-33　2015　Research paper (international conference proceedings)

Detection of self-reactive CD8+ T cells with an anergic phenotype in healthy individuals

Yuka Maeda, Hiroyoshi Nishikawa, Daisuke Sugiyama, Danbee Ha, Masahide Hamaguchi, Takuro Saito, Megumi Nishioka, James B. Wing, Dennis Adeegbe, Ichiro Katayama, Shimon Sakaguchi

Science　Vol. 346　No. 6216　p. 1536-1540　2014/12/19　Research paper (scientific journal)

Regulatory T cells control antigen-specific expansion of Tfh cell number and humoral immune responses via the coreceptor CTLA-4

James Badger Wing, Wataru Ise, Tomohiro Kurosaki, Shimon Sakaguchi

Immunity　Vol. 41　No. 6　p. 1013-1025　2014/12/18　Research paper (scientific journal)

Interleukin-10-producing plasmablasts exert regulatory function in autoimmune inflammation

Masanori Matsumoto, Akemi Baba, Takafumi Yokota, Hiroyoshi Nishikawa, Yasuyuki Ohkawa, Hisako Kayama, Axel Kallies, Stephen L. Nutt, Shimon Sakaguchi, Kiyoshi Takeda, Tomohiro Kurosaki, Yoshihiro Baba

Immunity　Vol. 41　No. 6　p. 1040-1051　2014/12/18　Research paper (scientific journal)

Autosomal dominant immune dysregulation syndrome in humans with CTLA4 mutations

Desireé Schubert, Claudia Bode, Rupert Kenefeck, Tie Zheng Hou, James B. Wing, Alan Kennedy, Alla Bulashevska, Britt-Sabina Petersen, Alejandro A. Schäffer, Björn A. Grüning, Susanne Unger, Natalie Frede, Ulrich Baumann, Torsten Witte, Reinhold E. Schmidt, Gregor Dueckers, Tim Niehues, Suranjith Seneviratne, Maria Kanariou, Carsten Speckmann, Stephan Ehl, Anne Rensing-Ehl, Klaus Warnatz, Mirzokhid Rakhmanov, Robert Thimme, Peter Hasselblatt, Florian Emmerich, Toni Cathomen, Rolf Backofen, Paul Fisch, Maximilian Seidl, Annette May, Annette Schmitt-Graeff, Shinji Ikemizu, Ulrich Salzer, Andre Franke, Shimon Sakaguchi, Lucy S. K. Walker, David M. Sansom, Bodo Grimbacher

Nature Medicine　Vol. 20　No. 12　p. 1410-1416　2014/12/01　Research paper (scientific journal)

抗体修飾表面による制御性T細胞の選択的捕獲

小林 健太郎, 木村 剛, 中村 奈緒子, 梅田 貫史, 南 広祐, 坂口 志文, 木村 俊作, 岸田 晶夫

日本バイオマテリアル学会大会予稿集　Vol. 36回　p. 136-136　2014/11

Continuous T Cell Receptor Signals Maintain a Functional Regulatory T Cell Pool

J. Christoph Vahl, Christoph Drees, Klaus Heger, Sylvia Heink, Julius C. Fischer, Jelena Nedjic, Naganari Ohkura, Hiromasa Morikawa, Hendrik Poeck, Sonja Schallenberg, David Riess, Marco Y. Hein, Thorsten Buch, Bojan Polic, Anne Schoenle, Robert Zeiser, Annette Schmitt-Graeff, Karsten Kretschmer, Ludger Klein, Thomas Korn, Shimon Sakaguchi, Marc Schmidt-Supprian

IMMUNITY　Vol. 41　No. 5　p. 722-736　2014/11　Research paper (scientific journal)

Detection of T cell responses to a ubiquitous cellular protein in autoimmune disease

Yoshinaga Ito, Motomu Hashimoto, Keiji Hirota, Naganari Ohkura, Hiromasa Morikawa, Hiroyoshi Nishikawa, Atsushi Tanaka, Moritoshi Furu, Hiromu Ito, Takao Fujii, Takashi Nomura, Sayuri Yamazaki, Akimichi Morita, Dario A. A. Vignali, John W. Kappler, Shuichi Matsuda, Tsuneyo Mimori, Noriko Sakaguchi, Shimon Sakaguchi

SCIENCE　Vol. 346　No. 6207　p. 363-368　2014/10　Research paper (scientific journal)

免疫療法を目指したターゲット細胞捕獲表面の設計

木村 剛, 中村 奈緒子, 伊東 愛, 岩田 拓也, 佐々木 直, 梅田 貫史, 南 広祐, 木村 俊作, 坂口 志文, 岸田 晶夫

生活生命支援医療福祉工学系学会連合大会講演要旨集　Vol. 2014　p. 53-53　2014/09

免疫療法を目指したターゲット細胞捕獲表面の設計

木村 剛, 中村 奈緒子, 伊東 愛, 岩田 拓也, 佐々木 直, 梅田 貫史, 南 広祐, 木村 俊作, 坂口 志文, 岸田 晶夫

生活生命支援医療福祉工学系学会連合大会講演要旨集　Vol. 2014　p. OS5-2　2014/09

Mogamulizumab投与に関連した抗ガングリオシド抗体陽性脳幹脳炎(Brainstem Encephalitis with anti-ganglioside antibody associated with mogamulizumab treatment)

Ureshino Hiroshi, Shindo Takero, Miyahara Masaharu, Nishikawa Hiroyoshi, Sakaguchi Shimon, Samukawa Makoto, Kusunoki Susumu, Kimura Shinya

臨床血液　Vol. 55　No. 9　p. 1489-1489　2014/09

Transient Ablation of Regulatory T cells Improves Antitumor Immunity in Colitis-Associated Colon Cancer

Eva Pastille, Katrin Bardini, Diana Fleissner, Alexandra Adamczyk, Annika Frede, Munisch Wadwa, Dorthe von Smolinski, Stefan Kasper, Tim Sparwasser, Achim D. Gruber, Martin Schuler, Shimon Sakaguchi, Axel Roers, Werner Mueller, Wiebke Hansen, Jan Buer, Astrid M. Westendorf

CANCER RESEARCH　Vol. 74　No. 16　p. 4258-4269　2014/08　Research paper (scientific journal)

CD8+tumor-infiltrating lymphocytes at primary sites as a possible prognostic factor of cutaneous angiosarcoma

Hiroko Fujii, Akiko Arakawa, Daisuke Utsumi, Shinji Sumiyoshi, Yosuke Yamamoto, Akihiko Kitoh, Masahiro Ono, Yumi Matsumura, Mayumi Kato, Keisuke Konishi, Takeo Shiga, Shigetoshi Sano, Shimon Sakaguchi, Aya Miyagawa-Hayashino, Kenzo Takahashi, Hiroshi Uezato, Yoshiki Miyachi, Miki Tanioka

International Journal of Cancer　Vol. 134　No. 10　p. 2393-2402　2014/05/15　Research paper (scientific journal)

Genetic and epigenetic basis of Treg cell development and function: from a FoxP3-centered view to an epigenome-defined view of natural Treg cells

Hiromasa Morikawa, Shimon Sakaguchi

IMMUNOLOGICAL REVIEWS　Vol. 259　No. 1　p. 192-205　2014/05

CD28 signals the differential control of regulatory T cells and effector T cells

Norihisa Mikami, Shimon Sakaguchi

EUROPEAN JOURNAL OF IMMUNOLOGY　Vol. 44　No. 4　p. 955-957　2014/04

Differential roles of epigenetic changes and Foxp3 expression in regulatory T cell-specific transcriptional regulation

Hiromasa Morikawa, Naganari Ohkura, Alexis Vandenbon, Masayoshi Itoh, Sayaka Nagao-Sato, Hideya Kawaji, Timo Lassmann, Piero Carninci, Yoshihide Hayashizaki, Alistair R. R. Forrest, Daron M. Standley, Hiroshi Date, Shimon Sakaguchi

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　Vol. 111　No. 14　p. 5289-5294　2014/04　Research paper (scientific journal)

A promoter-level mammalian expression atlas.

Alistair R R Forrest, Hideya Kawaji, Michael Rehli, J Kenneth Baillie, Michiel J L de Hoon, Vanja Haberle, Timo Lassmann, Ivan V Kulakovskiy, Marina Lizio, Masayoshi Itoh, Robin Andersson, Christopher J Mungall, Terrence F Meehan, Sebastian Schmeier, Nicolas Bertin, Mette Jørgensen, Emmanuel Dimont, Erik Arner, Christian Schmidl, Ulf Schaefer, Yulia A Medvedeva, Charles Plessy, Morana Vitezic, Jessica Severin, Colin A Semple, Yuri Ishizu, Robert S Young, Margherita Francescatto, Intikhab Alam, Davide Albanese, Gabriel M Altschuler, Takahiro Arakawa, John A C Archer, Peter Arner, Magda Babina, Sarah Rennie, Piotr J Balwierz, Anthony G Beckhouse, Swati Pradhan-Bhatt, Judith A Blake, Antje Blumenthal, Beatrice Bodega, Alessandro Bonetti, James Briggs, Frank Brombacher, A Maxwell Burroughs, Andrea Califano, Carlo V Cannistraci, Daniel Carbajo, Yun Chen, Marco Chierici, Yari Ciani, Hans C Clevers, Emiliano Dalla, Carrie A Davis, Michael Detmar, Alexander D Diehl, Taeko Dohi, Finn Drabløs, Albert S B Edge, Matthias Edinger, Karl Ekwall, Mitsuhiro Endoh, Hideki Enomoto, Michela Fagiolini, Lynsey Fairbairn, Hai Fang, Mary C Farach-Carson, Geoffrey J Faulkner, Alexander V Favorov, Malcolm E Fisher, Martin C Frith, Rie Fujita, Shiro Fukuda, Cesare Furlanello, Masaaki Furino, Jun-ichi Furusawa, Teunis B Geijtenbeek, Andrew P Gibson, Thomas Gingeras, Daniel Goldowitz, Julian Gough, Sven Guhl, Reto Guler, Stefano Gustincich, Thomas J Ha, Masahide Hamaguchi, Mitsuko Hara, Matthias Harbers, Jayson Harshbarger, Akira Hasegawa, Yuki Hasegawa, Takehiro Hashimoto, Meenhard Herlyn, Kelly J Hitchens, Shannan J Ho Sui, Oliver M Hofmann, Ilka Hoof, Furni Hori, Lukasz Huminiecki, Kei Iida, Tomokatsu Ikawa, Boris R Jankovic, Hui Jia, Anagha Joshi, Giuseppe Jurman, Bogumil Kaczkowski, Chieko Kai, Kaoru Kaida, Ai Kaiho, Kazuhiro Kajiyama, Mutsumi Kanamori-Katayama, Artem S Kasianov, Takeya Kasukawa, Shintaro Katayama, Sachi Kato, Shuji Kawaguchi, Hiroshi Kawamoto, Yuki I Kawamura, Tsugumi Kawashima, Judith S Kempfle, Tony J Kenna, Juha Kere, Levon M Khachigian, Toshio Kitamura, S Peter Klinken, Alan J Knox, Miki Kojima, Soichi Kojima, Naoto Kondo, Haruhiko Koseki, Shigeo Koyasu, Sarah Krampitz, Atsutaka Kubosaki, Andrew T Kwon, Jeroen F J Laros, Weonju Lee, Andreas Lennartsson, Kang Li, Berit Lilje, Leonard Lipovich, Alan Mackay-Sim, Ri-ichiroh Manabe, Jessica C Mar, Benoit Marchand, Anthony Mathelier, Niklas Mejhert, Alison Meynert, Yosuke Mizuno, David A de Lima Morais, Hiromasa Morikawa, Mitsuru Morimoto, Kazuyo Moro, Efthymios Motakis, Hozumi Motohashi, Christine L Mummery, Mitsuyoshi Murata, Sayaka Nagao-Sato, Yutaka Nakachi, Fumio Nakahara, Toshiyuki Nakamura, Yukio Nakamura, Kenichi Nakazato, Erik van Nimwegen, Noriko Ninomiya, Hiromi Nishiyori, Shohei Noma, Shohei Noma, Tadasuke Noazaki, Soichi Ogishima, Naganari Ohkura, Hiroko Ohimiya, Hiroshi Ohno, Mitsuhiro Ohshima, Mariko Okada-Hatakeyama, Yasushi Okazaki, Valerio Orlando, Dmitry A Ovchinnikov, Arnab Pain, Robert Passier, Margaret Patrikakis, Helena Persson, Silvano Piazza, James G D Prendergast, Owen J L Rackham, Jordan A Ramilowski, Mamoon Rashid, Timothy Ravasi, Patrizia Rizzu, Marco Roncador, Sugata Roy, Morten B Rye, Eri Saijyo, Antti Sajantila, Akiko Saka, Shimon Sakaguchi, Mizuho Sakai, Hiroki Sato, Suzana Savvi, Alka Saxena, Claudio Schneider, Erik A Schultes, Gundula G Schulze-Tanzil, Anita Schwegmann, Thierry Sengstag, Guojun Sheng, Hisashi Shimoji, Yishai Shimoni, Jay W Shin, Christophe Simon, Daisuke Sugiyama, Takaai Sugiyama, Masanori Suzuki, Naoko Suzuki, Rolf K Swoboda, Peter A C 't Hoen, Michihira Tagami, Naoko Takahashi, Jun Takai, Hiroshi Tanaka, Hideki Tatsukawa, Zuotian Tatum, Mark Thompson, Hiroo Toyodo, Tetsuro Toyoda, Elvind Valen, Marc van de Wetering, Linda M van den Berg, Roberto Verado, Dipti Vijayan, Ilya E Vorontsov, Wyeth W Wasserman, Shoko Watanabe, Christine A Wells, Louise N Winteringham, Ernst Wolvetang, Emily J Wood, Yoko Yamaguchi, Masayuki Yamamoto, Misako Yoneda, Yohei Yonekura, Shigehiro Yoshida, Susan E Zabierowski, Peter G Zhang, Xiaobei Zhao, Silvia Zucchelli, Kim M Summers, Harukazu Suzuki, Carsten O Daub, Jun Kawai, Peter Heutink, Winston Hide, Tom C Freeman, Boris Lenhard, Vladimir B Bajic, Martin S Taylor, Vsevolod J Makeev, Albin Sandelin, David A Hume, Piero Carninci, Yoshihide Hayashizaki

Nature　Vol. 507　No. 7493　p. 462-70　2014/03/27　Research paper (scientific journal)

免疫療法を目指したターゲット細胞捕獲デバイスの開発

木村 剛, 中村 奈緒子, 伊東 愛, 岩田 拓也, 南 広祐, 木村 俊作, 坂口 志文, 岸田 晶夫

生体材料工学研究所年報　Vol. 47　p. 16-18　2014/03

MS5-6 ロドデノール誘発脱色素斑患者の抹消血中T細胞に関する探索的解析(MS5 化粧品による健康被害,ミニシンポジウム,第26回日本アレルギー学会春季臨床大会)

西岡 めぐみ, 種村 篤, 西川 博嘉, 坂口 志文, 片山 一朗

アレルギー　Vol. 63　No. 3　p. 509-509　2014

Regulatory T-cell directed therapies in liver diseases

Ye Htun Oo, Shimon Sakaguchi

JOURNAL OF HEPATOLOGY　Vol. 59　No. 5　p. 1127-1134　2013/11　Research paper (scientific journal)

Anti-CCR4 mAb selectively depletes effector-Type FoxP3+CD4+ regulatory T cells, evoking antitumor immune responses in humans

Daisuke Sugiyama, Hiroyoshi Nishikawa, Yuka Maeda, Megumi Nishioka, Atsushi Tanemura, Ichiro Katayama, Sachiko Ezoe, Yuzuru Kanakura, Eiichi Sato, Yasuo Fukumori, Julia Karbach, Elke Jäger, Shimon Sakaguchi

Proceedings of the National Academy of Sciences of the United States of America　Vol. 110　No. 44　p. 17945-17950　2013/10/29　Research paper (scientific journal)

特異的リンパ球の回収を目指した抗体修飾基材の開発

木村 剛, 中村 奈緒子, 岩田 拓也, 南 広祐, 木村 俊作, 坂口 志文, 岸田 晶夫

生活生命支援医療福祉工学系学会連合大会講演要旨集　Vol. 2013　p. OS3-2　2013/09

T-reg induction by a rationally selected mixture of Clostridia strains from the human microbiota

Koji Atarashi, Takeshi Tanoue, Kenshiro Oshima, Wataru Suda, Yuji Nagano, Hiroyoshi Nishikawa, Shinji Fukuda, Takuro Saito, Seiko Narushima, Koji Hase, Sangwan Kim, Joelle V. Fritz, Paul Wilmes, Satoshi Ueha, Kouji Matsushima, Hiroshi Ohno, Bernat Olle, Shimon Sakaguchi, Tadatsugu Taniguchi, Hidetoshi Morita, Masahira Hattori, Kenya Honda

NATURE　Vol. 500　No. 7461　p. 232-+　2013/08　Research paper (scientific journal)

Testosterone Is Protective in the Sexually Dimorphic Development of Arthritis and Lung Disease in SKG Mice

Rebecca C. Keith, Jeremy Sokolove, Benjamin L. Edelman, Lauren Lahey, Elizabeth F. Redente, V. Michael Holers, Shimon Sakaguchi, William H. Robinson, David W. H. Riches

ARTHRITIS AND RHEUMATISM　Vol. 65　No. 6　p. 1487-1493　2013/06　Research paper (scientific journal)

Construction of self-recognizing regulatory T cells from conventional T cells by controlling CTLA-4 and IL-2 expression

Tomoyuki Yamaguchi, Ayumi Kishi, Motonao Osaki, Hiromasa Morikawa, Paz Prieto-Martin, Kajsa Wing, Takashi Saito, Shimon Sakaguchi

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　Vol. 110　No. 23　p. E2116-E2125　2013/06　Research paper (scientific journal)

SKG arthritis as a model for evaluating therapies in rheumatoid arthritis with special focus on bone changes

Kresten Krarup Keller, Lisa Mejlvang Lindgaard, Lise Wogensen, Frederik Dagnæs-Hansen, Jesper Skovhus Thomsen, Shimon Sakaguchi, Kristian Stengaard-Pedersen, Ellen-Margrethe Hauge

Rheumatology International　Vol. 33　No. 5　p. 1127-1133　2013/05　Research paper (scientific journal)

Overcoming regulatory T-cell suppression by a lyophilized preparation of Streptococcus pyogenes

Michiko Hirayama, Hiroyoshi Nishikawa, Yasuhiro Nagata, Takemasa Tsuji, Takuma Kato, Shinichi Kageyama, Shugo Ueda, Daisuke Sugiyama, Sahoko Hori, Shimon Sakaguchi, Gerd Ritter, Lloyd J. Old, Sacha Gnjatic, Hiroshi Shiku

European Journal of Immunology　Vol. 43　No. 4　p. 989-1000　2013/04　Research paper (scientific journal)

Identification of novel markers for mouse CD4+ T follicular helper cells

Smita S. Iyer, Donald R. Latner, Michael J. Zilliox, Megan Mccausland, Rama S. Akondy, Pablo Penaloza-Macmaster, Jeffrey Scott Hale, Lilin Ye, Ata-Ur-Rasheed Mohammed, Tomoyuki Yamaguchi, Shimon Sakaguchi, Rama R. Amara, Rafi Ahmed

European Journal of Immunology　Vol. 43　No. 12　p. 3219-3232　2013　Research paper (scientific journal)

Expression of CD4(+)CD25(high+) Regulatory T Cells in Miniature Swine

Yan-Ling Wu, Yan-Ping Ding, Chuan-He Wei, Eiji Kobayashi, Shimon Sakaguchi, Takaaki Koshiba

ENVIRONMENTAL PROTECTION AND RESOURCES EXPLOITATION, PTS 1-3　Vol. 807-809　p. 708-+　2013　Research paper (international conference proceedings)

Regulatory T cells

Shimon Sakaguchi, Kajsa Wing, Makoto Miyara

Clinical Immunology: Principles and Practice: Fourth Edition　p. 193-202　2012/12/12　Part of collection (book)

T Cell Receptor Stimulation-Induced Epigenetic Changes and Foxp3 Expression Are Independent and Complementary Events Required for Treg Cell Development

Naganari Ohkura, Masahide Hamaguchi, Hiromasa Morikawa, Kyoko Sugimura, Atsushi Tanaka, Yoshinaga Ito, Motonao Osaki, Yoshiaki Tanaka, Riu Yamashita, Naoko Nakano, Jochen Huehn, Hans Joerg Fehling, Tim Sparwasser, Kenta Nakai, Shimon Sakaguchi

IMMUNITY　Vol. 37　No. 5　p. 785-799　2012/11　Research paper (scientific journal)

Neuropilin 1 deficiency on CD4(+)Foxp3(+) regulatory T cells impairs mouse melanoma growth

Wiebke Hansen, Marina Hutzler, Simone Abel, Christina Alter, Christian Stockmann, Stefanie Kliche, Juliane Albert, Tim Sparwasser, Shimon Sakaguchi, Astrid M. Westendorf, Dirk Schadendorf, Jan Buer, Iris Helfrich

JOURNAL OF EXPERIMENTAL MEDICINE　Vol. 209　No. 11　p. 2001-2016　2012/10　Research paper (scientific journal)

Dietary Folic Acid Promotes Survival of Foxp3(+) Regulatory T Cells in the Colon

Makoto Kinoshita, Hisako Kayama, Takashi Kusu, Tomoyuki Yamaguchi, Jun Kunisawa, Hiroshi Kiyono, Shimon Sakaguchi, Kiyoshi Takeda

JOURNAL OF IMMUNOLOGY　Vol. 189　No. 6　p. 2869-2878　2012/09　Research paper (scientific journal)

Regulatory T cells expressing PPAR-γ control inflammation in obesity

Masahide Hamaguchi, Shimon Sakaguchi

Cell Metabolism　Vol. 16　No. 1　p. 4-6　2012/07/03　Research paper (scientific journal)

Intracellular Tumor-Associated Antigens Represent Effective Targets for Passive Immunotherapy

Takuro Noguchi, Takuma Kato, Linan Wang, Yuka Maeda, Hiroaki Ikeda, Eiichi Sato, Alexander Knuth, Sacha Gnjatic, Gerd Ritter, Shimon Sakaguchi, Lloyd J. Old, Hiroshi Shiku, Hiroyoshi Nishikawa

CANCER RESEARCH　Vol. 72　No. 7　p. 1672-1682　2012/04　Research paper (scientific journal)

Cancer/testis antigens are novel targets of immunotherapy for adult T-cell leukemia/lymphoma

Hiroyoshi Nishikawa, Yuka Maeda, Takashi Ishida, Sacha Gnjatic, Eiichi Sato, Fumiko Mori, Daisuke Sugiyama, Asahi Ito, Yasuo Fukumori, Atae Utsunomiya, Hiroshi Inagaki, Lloyd J. Old, Ryuzo Ueda, Shimon Sakaguchi

Blood　Vol. 119　No. 13　p. 3097-3104　2012/03/29　Research paper (scientific journal)

Differential effects of inhibition of bone morphogenic protein (BMP) signalling on T-cell activation and differentiation

Yumiko Yoshioka, Masahiro Ono, Motonao Osaki, Ikuo Konishi, Shimon Sakaguchi

European Journal of Immunology　Vol. 42　No. 3　p. 749-759　2012/03　Research paper (scientific journal)

A novel model of rheumatoid arthritis-associated interstitial lung disease in SKG mice

Rebecca C. Keith, Jennifer L. Powers, Elizabeth F. Redente, Amen Sergew, Richard J. Martin, Alison Gizinski, V. Michael Holers, Shimon Sakaguchi, David W. H. Riches

EXPERIMENTAL LUNG RESEARCH　Vol. 38　No. 2　p. 55-66　2012/03　Research paper (scientific journal)

発育中胸腺細胞のT細胞レパートリーの矯正によるSKGマウスの自己免疫性関節炎の防御(Rescue of autoimmune arthritis in SKG mice by correction of T-cell repertoire in developing thymocytes)

前田 伸治, 田中 聡, 上田 龍三, 坂口 志文

Nagoya Medical Journal　Vol. 52　No. 2　p. 77-88　2012/02

A trans-ethnic genetic study of rheumatoid arthritis identified FCGR2A as a candidate common risk factor in Japanese and European populations

Roubila Meziani, Ryo Yamada, Meiko Takahashi, Kenei Ohigashi, Akio Morinobu, Chikashi Terao, Hitomi Hiratani, Koichiro Ohmura, Masao Yamaguchi, Takashi Nomura, Alexandre Vasilescu, Miki Kokubo, Victor Renault, Katsura Hirosawa, Chanavee Ratanajaraya, Simon Heath, Tsuneyo Mimori, Shimon Sakaguchi, Mark Lathrop, Inga Melchers, Shunichi Kumagai, Fumihiko Matsuda

Modern Rheumatology　Vol. 22　No. 1　p. 52-58　2012/02　Research paper (scientific journal)

Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3(+)CD25(+)CD4(+) regulatory T cells (vol 202, pg 885, 2005)

Kuibeom Ko, Sayuri Yamazaki, Kyoko Nakamura, Tomohisa Nishioka, Keiji Hirota, Tomoyuki Yamaguchi, Jun Shimizu, Takashi Nomura, Tsutomu Chiba, Shimon Sakaguchi

JOURNAL OF EXPERIMENTAL MEDICINE　Vol. 209　No. 2　2012/02

Structural Biology for Understanding Genetic Basis of Disease Susceptibility

SAKAGUCHI Shimon

tits　Vol. 17　No. 12　p. 12_22-12_23　2012

Factors affecting operational tolerance after pediatric living-donor liver transplantation: Impact of early post-transplant events and HLA match

Hidenori Ohe, Kayo Waki, Mami Yoshitomi, Takeshi Morimoto, Hanaa Nafady-Hego, Naoki Satoda, Ying Li, Xiangdong Zhao, Shimon Sakaguchi, Shinji Uemoto, G. Alex Bishop, Takaaki Koshiba

Transplant International　Vol. 25　No. 1　p. 97-106　2012/01　Research paper (scientific journal)

Re-establishing immunological self-tolerance in autoimmune disease

Shimon Sakaguchi, Fiona Powrie, Richard M. Ransohoff

NATURE MEDICINE　Vol. 18　No. 1　p. 54-58　2012/01　Research paper (scientific journal)

Thymus, innate immunity and autoimmune arthritis: Interplay of gene and environment

Shimon Sakaguchi, Satoshi Tanaka, Atsushi Tanaka, Yoshinaga Ito, Shinji Maeda, Noriko Sakaguchi, Motomu Hashimoto

FEBS LETTERS　Vol. 585　No. 23　p. 3633-3639　2011/12

The Long-Term Survival Potential of Mature T Lymphocytes Is Programmed During Development in the Thymus

Charles Sinclair, Manoj Saini, Ina Schim van der Loeff, Shimon Sakaguchi, Benedict Seddon

SCIENCE SIGNALING　Vol. 4　No. 199　2011/11　Research paper (scientific journal)

TCRシグナル伝達補正によるSKGマウス自己免疫性関節炎の発症抑制

前田 伸治, 田中 聡, 坂口 教子, 坂口 志文

日本臨床免疫学会会誌　Vol. 34　No. 4　p. 275-275　2011/08

関節リウマチの病因・病態 正常ZAP-70の発現量操作による自己免疫性関節炎の誘導(第2報)

前田 伸治, 田中 聡, 秋月 修治, 橋本 求, 坂口 志文

日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集　Vol. 55回・20回　p. 262-262　2011/06

Perturbations of both nonregulatory and regulatory FOXP3+ T cells in patients with malignant melanoma

H. Fujii, A. Arakawa, A. Kitoh, M. Miyara, M. Kato, S. Kore-Eda, S. Sakaguchi, Y. Miyachi, M. Tanioka, M. Ono

British Journal of Dermatology　Vol. 164　No. 5　p. 1052-1060　2011/05　Research paper (scientific journal)

Immunologic Self-Tolerance Maintained by Activated T Cells Expressing IL-2 Receptor alpha-Chains (CD25) Breakdown of a Single Mechanism of Self-Tolerance Causes Various Autoimmune Diseases

Shimon Sakaguchi, Noriko Sakaguchi, Masanao Asano, Misako Itoh, Masaaki Toda

JOURNAL OF IMMUNOLOGY　Vol. 186　No. 7　p. 1151-1164　2011/04　Research paper (scientific journal)

Immunologic Self-Tolerance Maintained by Activated T Cells Expressing IL-2 Receptor alpha-Chains (CD25) Breakdown of a Single Mechanism of Self-Tolerance Causes Various Autoimmune Diseases

Shimon Sakaguchi, Noriko Sakaguchi, Masanao Asano, Misako Itoh, Masaaki Toda

JOURNAL OF IMMUNOLOGY　Vol. 186　No. 7　p. 3808-3821　2011/04　Research paper (scientific journal)

CSF-1-dependent red pulp macrophages regulate CD4 T cell responses.

Daisuke Kurotaki, Shigeyuki Kon, Kyeonghwa Bae, Koyu Ito, Yutaka Matsui, Yosuke Nakayama, Masashi Kanayama, Chiemi Kimura, Yoshinori Narita, Takashi Nishimura, Kazuya Iwabuchi, Matthias Mack, Nico van Rooijen, Shimon Sakaguchi, Toshimitsu Uede, Junko Morimoto

Journal of immunology (Baltimore, Md. : 1950)　Vol. 186　No. 4　p. 2229-37　2011/02/15

SLAP Deficiency Enhances Number and Function of Regulatory T Cells Preventing Chronic Autoimmune Arthritis in SKG Mice

Lisa K. Peterson, Laura A. Shaw, Anthony Joetham, Shimon Sakaguchi, Erwin W. Gelfand, Leonard L. Dragone

JOURNAL OF IMMUNOLOGY　Vol. 186　No. 4　p. 2273-2281　2011/02　Research paper (scientific journal)

HTLV-1 bZIP Factor Induces T-Cell Lymphoma and Systemic Inflammation In Vivo

Yorifumi Satou, Jun-ichirou Yasunaga, Tiejun Zhao, Mika Yoshida, Paola Miyazato, Ken Takai, Kei Shimizu, Koichi Ohshima, Patrick L. Green, Naganari Ohkura, Tomoyuki Yamaguchi, Masahiro Ono, Shimon Sakaguchi, Masao Matsuoka

PLOS PATHOGENS　Vol. 7　No. 2　2011/02　Research paper (scientific journal)

Stimulation of the Glucocorticoid-Induced TNF Receptor Family-Related Receptor on CD8 T Cells Induces Protective and High-Avidity T Cell Responses to Tumor-Specific Antigens

Anik L. Cote, Peisheng Zhang, Jeremy A. O'Sullivan, Valerie L. Jacobs, Carli R. Clemis, Shimon Sakaguchi, Jose A. Guevara-Patino, Mary Jo Turk

JOURNAL OF IMMUNOLOGY　Vol. 186　No. 1　p. 275-283　2011/01　Research paper (scientific journal)

IMPAIRED FUNCTION OF REGULATORY T CELLS BY HTLV-1 bZIP FACTOR(HBZ)

Paola Miyazato, Yorifumi Satou, Tomoyuki Yamaguchi, Shimon Sakaguchi, Kouichi Ohshima, Masao Matsuoka

International Union of Microbiological Societies 2011 Congress. Sappaoro, Japan. September 11-16, 2011.　2011

CD8 T Cell-Intrinsic GITR Is Required for T Cell Clonal Expansion and Mouse Survival following Severe Influenza Infection

Laura M. Snell, Ann J. McPherson, Gloria H. Y. Lin, Shimon Sakaguchi, Pier Paolo Pandolfi, Carlo Riccardi, Tania H. Watts

JOURNAL OF IMMUNOLOGY　Vol. 185　No. 12　p. 7223-7234　2010/12　Research paper (scientific journal)

The Generation of Donor-Specific CD4(+)CD25(++)CD45RA(+) Naive Regulatory T Cells in Operationally Tolerant Patients After Pediatric Living-Donor Liver Transplantation

Hanaa Nafady-Hego, Ying Li, Hidenori Ohe, Xiangdong Zhao, Naoki Satoda, Shimon Sakaguchi, Kathryn Wood, Shinji Uemoto, Takaaki Koshiba

TRANSPLANTATION　Vol. 90　No. 12　p. 1547-1555　2010/12　Research paper (scientific journal)

Regulatory T cells in tumor immunity

Hiroyoshi Nishikawa, Shimon Sakaguchi

INTERNATIONAL JOURNAL OF CANCER　Vol. 127　No. 4　p. 759-767　2010/08　Research paper (scientific journal)

Graded Attenuation of TCR Signaling Elicits Distinct Autoimmune Diseases by Altering Thymic T Cell Selection and Regulatory T Cell Function

Satoshi Tanaka, Shinji Maeda, Motomu Hashimoto, Chihiro Fujimori, Yoshinaga Ito, Shin Teradaira, Keiji Hirota, Hiroyuki Yoshitomi, Tomoya Katakai, Akira Shimizu, Takashi Nomura, Noriko Sakaguchi, Shimon Sakaguchi

JOURNAL OF IMMUNOLOGY　Vol. 185　No. 4　p. 2295-2305　2010/08　Research paper (scientific journal)

Complement drives Th17 cell differentiation and triggers autoimmune arthritis

Motomu Hashimoto, Keiji Hirota, Hiroyuki Yoshitomi, Shinji Maeda, Shin Teradaira, Shuji Akizuki, Paz Prieto-Martin, Takashi Nomura, Noriko Sakaguchi, Joerg Koehl, Birgitta Heyman, Minoru Takahashi, Teizo Fujita, Tsuneyo Mimori, Shimon Sakaguchi

JOURNAL OF EXPERIMENTAL MEDICINE　Vol. 207　No. 6　p. 1135-1143　2010/06　Research paper (scientific journal)

Two distinct mechanisms of augmented antitumor activity by modulation of immunostimulatory/inhibitory signals

Jun Mitsui, Hiroyoshi Nishikawa, Daisuke Muraoka, Linan Wang, Takuro Noguchi, Eiichi Sato, Satoshi Kondo, James P. Allison, Shimon Sakaguchi, Lloyd J. Old, Takuma Kato, Hiroshi Shiku

Clinical Cancer Research　Vol. 16　No. 10　p. 2781-2791　2010/05/15　Research paper (scientific journal)

Multiple Antitumor Mechanisms Downstream of Prophylactic Regulatory T-Cell Depletion

Michele W. L. Teng, Jeremy B. Swann, Bianca von Scheidt, Janelle Sharkey, Nadeen Zerafa, Nicole McLaughlin, Tomoyuki Yamaguchi, Shimon Sakaguchi, Phillip K. Darcy, Mark J. Smyth

CANCER RESEARCH　Vol. 70　No. 7　p. 2665-2674　2010/04　Research paper (scientific journal)

Regulation of Zap70 expression during thymocyte development enables temporal separation of CD4 and CD8 repertoire selection at different signaling thresholds

Manoj Saini, Charles Sinclair, Daniel Marshall, Mauro Tolaini, Shimon Sakaguchi, Benedict Seddon

Science Signaling　Vol. 3　No. 114　2010/03/23　Research paper (scientific journal)

膠原病 病因 正常ZAP-70の発現量操作による自己免疫性関節炎の誘導

前田 伸治, 橋本 求, 秋月 修治, 伊藤 能永, 濱口 真英, 坂口 志文

日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集　Vol. 54回・19回　p. 496-496　2010/03

Therapeutic Glucocorticoid-Induced TNF Receptor-Mediated Amplification of CD4(+) T Cell Responses Enhances Antiparasitic Immunity

Ashraful Haque, Amanda C. Stanley, Fiona H. Amante, Fabian de Labastida Rivera, YongHong Zhou, Rachel D. Kuns, Vanessa Yardley, Shimon Sakaguchi, Geoffrey R. Hill, Christian R. Engwerda

JOURNAL OF IMMUNOLOGY　Vol. 184　No. 5　p. 2583-2592　2010/03　Research paper (scientific journal)

Chronic arthritis leads to disturbances in the bone collagen network

Joana Caetano-Lopes, Ana M. Nery, Helena Canhão, Joana Duarte, Rita Cascão, Ana Rodrigues, Inês P. Perpétuo, Saba Abdulghani, Pedro M. Amaral, Shimon Sakaguchi, Yrjö T. Konttinen, Luís Graça, Maria F. Vaz, João E. Fonseca

Arthritis Research and Therapy　Vol. 12　No. 1　2010/01/15　Research paper (scientific journal)

Indispensable Role of the Runx1-Cbf beta Transcription Complex for In Vivo-Suppressive Function of FoxP3(+) Regulatory T Cells

Akihiko Kitoh, Masahiro Ono, Yoshinori Naoe, Naganari Ohkura, Tomoyuki Yamaguchi, Hiroko Yaguchi, Issay Kitabayashi, Toshihiko Tsukada, Takashi Nomura, Yoshiki Miyachi, Ichiro Taniuchi, Shimon Sakaguchi

IMMUNITY　Vol. 31　No. 4　p. 609-620　2009/10　Research paper (scientific journal)

CD4+CD25-LAG3+ regulatory T cells controlled by the transcription factor Egr-2

Tomohisa Okamura, Keishi Fujio, Mihoko Shibuya, Shuji Sumitomo, Hirofumi Shoda, Shimon Sakaguchi, Kazuhiko Yamamoto

Proceedings of the National Academy of Sciences of the United States of America　Vol. 106　No. 33　p. 13974-13979　2009/08/18　Research paper (scientific journal)

Enhancement of T-cell-mediated anti-tumour immunity via the ectopically expressed glucocorticoid-induced tumour necrosis factor receptor-related receptor ligand (GITRL) on tumours

Jinhua Piao, Yosuke Kamimura, Hideyuki Iwai, Yujia Cao, Keisuke Kikuchi, Masaaki Hashiguchi, Taro Masunaga, Hongsi Jiang, Kouichi Tamura, Shimon Sakaguchi, Miyuki Azuma

IMMUNOLOGY　Vol. 127　No. 4　p. 489-499　2009/08　Research paper (scientific journal)

Gamma/delta T cells are the predominant source of interleukin-17 in affected joints in collagen-induced arthritis, but not in rheumatoid arthritis.

Yoshinaga Ito, Takashi Usui, Shio Kobayashi, Mikiko Iguchi-Hashimoto, Hiromu Ito, Hiroyuki Yoshitomi, Takashi Nakamura, Masakazu Shimizu, Daisuke Kawabata, Naoichiro Yukawa, Motomu Hashimoto, Noriko Sakaguchi, Shimon Sakaguchi, Hajime Yoshifuji, Takaki Nojima, Koichiro Ohmura, Takao Fujii, Tsuneyo Mimori

Arthritis and rheumatism　Vol. 60　No. 8　p. 2294-303　2009/08　Research paper (scientific journal)

Therapeutic Immunity by Adoptive Tumor-primed CD4(+) T-cell Transfer in Combination With In Vivo GITR Ligation

Zuqiang Liu, Shenghe Tian, Louis D. Falo, Shimon Sakaguchi, Zhaoyang You

MOLECULAR THERAPY　Vol. 17　No. 7　p. 1274-1281　2009/07　Research paper (scientific journal)

Functional Delineation and Differentiation Dynamics of Human CD4(+) T Cells Expressing the FoxP3 Transcription Factor

Makoto Miyara, Yumiko Yoshioka, Akihiko Kitoh, Tomoko Shima, Kajsa Wing, Akira Niwa, Christophe Parizot, Cecile Taflin, Toshio Heike, Dominique Valeyre, Alexis Mathian, Tatsutoshi Nakahata, Tomoyuki Yamaguchi, Takashi Nomura, Masahiro Ono, Zahir Amoura, Guy Gorochov, Shimon Sakaguchi

IMMUNITY　Vol. 30　No. 6　p. 899-911　2009/06　Research paper (scientific journal)

Therapeutic approaches to allergy and autoimmunity based on FoxP3(+) regulatory T-cell activation and expansion

Makoto Miyara, Kajsa Wing, Shimon Sakaguchi

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY　Vol. 123　No. 4　p. 749-755　2009/04　Research paper (scientific journal)

Immune Rejection of Mouse Tumors Expressing Mutated Self

Fei Duan, Yun Lin, Cailian Liu, Manuel E. Engelhorn, Adam D. Cohen, Michael Curran, Shimon Sakaguchi, Taha Merghoub, Stephanie Terzulli, Jedd D. Wolchok, Alan N. Houghton

CANCER RESEARCH　Vol. 69　No. 8　p. 3545-3553　2009/04　Research paper (scientific journal)

Differential control of allo-antigen-specific regulatory T cells and effector T cells by anti-CD4 and other agents in establishing transplantation tolerance

Kanji Nagahama, Zoltan Fehervari, Takatoku Oida, Tomoyuki Yamaguchi, Osamu Ogawa, Shimon Sakaguchi

INTERNATIONAL IMMUNOLOGY　Vol. 21　No. 4　p. 379-391　2009/04　Research paper (scientific journal)

【膠原病 病態解明・新規治療の光明】病因・病態解明 免疫系異常 Th-1、Th-2、Th-17とT regなどの膠原病への関与

橋本 求, 坂口 志文

日本臨床　Vol. 67　No. 3　p. 482-486　2009/03

[Contribution of Th-1, Th-2, Th-17 or regulatory T cells to connective tissue diseases].

Motomu Hashimoto, Shimon Sakaguchi

Nihon rinsho. Japanese journal of clinical medicine　Vol. 67　No. 3　p. 482-6　2009/03　Research paper (scientific journal)

Requirement of Protocol Biopsy Before and After Complete Cessation of Immunosuppression After Liver Transplantation

Mami Yoshitomi, Takaaki Koshiba, Hironori Haga, Ying Li, Xiangdong Zhao, Donghua Cheng, Aya Miyagawa, Hiromi Sakashita, Tatsuaki Tsuruyama, Hidenori Ohe, Mikiko Ueda, Shinya Okamoto, Hiroto Egawa, Kathryn Wood, Shimon Sakaguchi, Toshiaki Manabe, Koichi Tanaka, Shinji Uemoto

TRANSPLANTATION　Vol. 87　No. 4　p. 606-614　2009/02　Research paper (scientific journal)

A simple detection method for low-affinity membrane protein interactions by baculoviral display

Toshiko Sakihama, Takato Sato, Hiroko Iwanari, Toshio Kitamura, Shimon Sakaguchi, Tatsuhiko Kodama, Takao Hamakubo

PLoS ONE　Vol. 3　No. 12　2008/12/24　Research paper (scientific journal)

Value of FOXP3 Expression in Peripheral Blood as Rejection Marker After Miniature Swine Lung Transplantation

Naoki Satoda, Tsuyoshi Shoji, Yanling Wu, Takuji Fujinaga, Fengshi Chen, Akihiro Aoyama, Ji Tian Zhang, Ayuko Takahashi, Toshihiro Okamoto, Izumi Matsumoto, Hiroaki Sakai, Ying Li, Xiangdong Zhao, Toshiaki Manabe, Eiji Kobayashi, Shimon Sakaguchi, Hiromi Wada, Hidenori Ohe, Shinji Uemoto, Junichi Tottori, Toru Bando, Hiroshi Date, Takaaki Koshiba

Journal of Heart and Lung Transplantation　Vol. 27　No. 12　p. 1293-1301　2008/12　Research paper (scientific journal)

The Presence of Foxp3 Expressing T Cells Within Grafts of Tolerant Human Liver Transplant Recipients

Ying Li, Xiangdong Zhao, Donghua Cheng, Hironori Haga, Tatsuaki Tsuruyama, Kathryn Wood, Shimon Sakaguchi, Koichi Tanaka, Shinji Uemoto, Takaaki Koshiba

TRANSPLANTATION　Vol. 86　No. 12　p. 1837-1843　2008/12　Research paper (scientific journal)

制御性T細胞 免疫系に自然に存在するIL-10産生性CD4+CD25-LAG3+制御性T細胞(Regulatory T cell IL-10 producing CD4+CD25-LAG3+ regulatory T cells naturally present in the immune system)

Yamamoto Kazuhiko, Okamura Tomohisa, Shibuya Mihoko, Sumitomo Shuji, Shoda Hirofumi, Sakaguchi Shimon, Fujio Keishi

日本免疫学会総会・学術集会記録　Vol. 38　p. 1-1　2008/11

臓器特異的自己免疫疾患 TCRシグナル不全による制御性T細胞分化障害と自己免疫病の発症

野村 尚史, 秋月 修治, 前田 伸治, 橋本 求, 斉藤 隆, 坂口 教子, 坂口 志文

日本免疫学会総会・学術集会記録　Vol. 38　p. 91-91　2008/11

全身性自己免疫疾患 モデル TCRシグナル伝達の補正によるSKGマウス自己免疫性関節炎の発症抑制(第2報)

前田 伸治, 田中 聡, 廣田 圭司, 橋本 求, 寺平 晋, 秋月 修治, 野村 尚史, 上田 龍三, 坂口 教子, 坂口 志文

日本免疫学会総会・学術集会記録　Vol. 38　p. 247-247　2008/11

CTLA-4 control over Foxp3(+) regulatory T cell function

Kajsa Wing, Yasushi Onishi, Paz Prieto-Martin, Tomoyuki Yamaguchi, Makoto Miyara, Zoltan Fehervari, Takashi Nomura, Shimon Sakaguchi

SCIENCE　Vol. 322　No. 5899　p. 271-275　2008/10　Research paper (scientific journal)

Arthritis and pneumonitis produced by the same T cell clones from mice with spontaneous autoimmune arthritis

Chiaki Wakasa-Morimoto, Tomoko Toyosaki-Maeda, Takaji Matsutani, Ryu Yoshida, Shino Nakamura-Kikuoka, Miki Maeda-Tanimura, Hiroyuki Yoshitomi, Keiji Hirota, Motomu Hashimoto, Hideyuki Masaki, Yoshiki Fujii, Tsuneaki Sakata, Yuji Tsuruta, Ryuji Suzuki, Noriko Sakaguchi, Shimon Sakaguchi

INTERNATIONAL IMMUNOLOGY　Vol. 20　No. 10　p. 1331-1342　2008/10　Research paper (scientific journal)

Systemic targeting of CpG-ODN to the tumor microenvironment with anti-neu-CpG hybrid molecule and T regulatory cell depletion induces memory responses in BALB-neuT tolerant mice

Sanjay Sharma, Ana Lucia Dominguez, Soraya Zorro Manrique, Federica Cavallo, Shimon Sakaguchi, Joseph Lustgarten

CANCER RESEARCH　Vol. 68　No. 18　p. 7530-7540　2008/09　Research paper (scientific journal)

Foxp3(+) natural regulatory T cells preferentially form aggregates on dendritic cells in vitro and actively inhibit their maturation

Yasushi Onishi, Zoltan Fehervari, Tomoyuki Yamaguchi, Shimon Sakaguchi

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　Vol. 105　No. 29　p. 10113-10118　2008/07　Research paper (scientific journal)

Regulatory T cells and immune tolerance

Shimon Sakaguchi, Tomoyuki Yamaguchi, Takashi Nomura, Masahiro Ono

CELL　Vol. 133　No. 5　p. 775-787　2008/05

関節リウマチ病態解明のトピックス マウスおよびヒト自己免疫性関節炎におけるCCL20を介したCCR6陽性Th17細胞の遊走

吉富 啓之, 橋本 求, 前田 伸治, 伊藤 宣, 中村 孝志, 坂口 志文

日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集　Vol. 52回・17回　p. 198-198　2008/04

Regulatory T cells in the past and for the future

Shimon Sakaguchi

European Journal of Immunology　Vol. 38　No. 4　p. 901-903　2008/04　Research paper (scientific journal)

Regulatory t cells

Kajsa Wing, Shimon Sakaguchi

Clinical Immunology　p. 249-258　2008　Part of collection (book)

Functional delineation and differentiation dynamics \nof FoxP3-expressing subpopulation of CD4＋ T cell in humans

Makoto Miyara, Tomoko Shima, Akihiko Kitoh, Yumiko Yosioka, Akira Niwa, Cecile Taflin, Toshio Heike, DominiqueValeyre, Alexis Mathian, Zahir Amoura, Tatsutoshi Nakahata, Tomoyuki Yamaguchi, Takashi Nomura, Kajsa Wing, Guy Gorochov, Masahiro Ono, Shimon Sakaguchi

World Immune Regulation Meeting-II (2008.3.17-20 Davos Switzerland)　2008

γδT 細胞はコラーゲン誘発性関 \n節炎局所における主要なIl-17 産生細胞である/Ganmma delta T cells are the predominant Il-17-produsing cells \nin affected joint of collagen-induced arthritis

Yoshinaga Ito, Takashi Usui, Shio Kobayashi, Mikiko Iguchi, Hiromu Ito, Hiroyoki Yoshitomi, Takashi Nakamura, Motomu Hashimoto, Noriko Sakaguchi, Shimon Sakaguchi, Tuneyo Mimori

第８回日本免疫学会学術集会（2008.12.1-3．京都）　2008

Regulatory T cells - A brief history and perspective

Shimon Sakaguchi, Kajsa Wing, Makoto Miyara

European Journal of Immunology　Vol. 37　No. 1　p. S116-S123　2007/11　Research paper (scientific journal)

Preferential recruitment of CCR6-expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model

Keiji Hirota, Hiroyuki Yoshitomi, Motomu Hashimoto, Shinji Maeda, Shin Teradaira, Naoshi Sugimoto, Tomoyuki Yamaguchi, Takashi Nomura, Hiromu Ito, Takashi Nakamura, Noriko Sakaguchi, Shimon Sakaguchi

JOURNAL OF EXPERIMENTAL MEDICINE　Vol. 204　No. 12　p. 2803-2812　2007/11　Research paper (scientific journal)

T細胞情報伝達異常とリウマチ性疾患

前田 伸治, 坂口 志文

リウマチ科　Vol. 38　No. 4　p. 391-396　2007/10

SKGマウスにおける自己反応性CD4+T細胞集団の解析

寺平 晋, 廣田 圭司, 橋本 求, 前田 伸治, 山口 智之, 野村 尚史, 坂口 教子, 坂口 志文

日本免疫学会総会・学術集会記録　Vol. 37　p. 173-173　2007/10

A combination of chemoimmunotherapies can efficiently break self-tolerance and induce antitumor immunity in a tolerogenic murine tumor model

Hyun-Jeong Ko, Yeon-Jeong Kim, Yun-Sun Kim, Woo-Sung Chang, Sung-Youl Ko, Sun-Young Chang, Shimon Sakaguchi, Chang-Yuil Kang

CANCER RESEARCH　Vol. 67　No. 15　p. 7477-7486　2007/08　Research paper (scientific journal)

Control of immune responses by antigen-specific regulatory T cells expressing the folate receptor

Tomoyuki Yamaguchi, Keiji Hirota, Kanji Nagahama, Katsuya Ohkawa, Takeshi Takahashi, Takeshi Nomura, Shimon Sakaguchi

IMMUNITY　Vol. 27　No. 1　p. 145-159　2007/07　Research paper (scientific journal)

Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1

Masahiro Ono, Hiroko Yaguchi, Naganari Ohkura, Issay Kitabayashi, Yuko Nagamura, Takashi Nomura, Yoshiki Miyachi, Toshihiko Tsukada, Shimon Sakaguchi

Nature　Vol. 446　No. 7136　p. 685-689　2007/04/05　Research paper (scientific journal)

ICER/CREM-mediated transcriptional attenuation of IL-2 and its role in suppression by regulatory T cells

Josef Bodor, Zoltan Fehervari, Betty Diamond, Shimon Sakaguchi

European Journal of Immunology　Vol. 37　No. 4　p. 884-895　2007/04　Research paper (scientific journal)

Clinical, immunological, and pathological aspects of operational tolerance after pediatric living-donor liver transplantation

Takaaki Koshiba, Ying Li, Mami Takemura, Yanling Wu, Shimon Sakaguchi, Nagahiro Minato, Kathryn J. Wood, Hironori Haga, Mikiko Ueda, Shinji Uemoto

TRANSPLANT IMMUNOLOGY　Vol. 17　No. 2　p. 94-97　2007/02　Research paper (scientific journal)

Regulatory T cell-mediated suppression: potential role of ICER

Josef Bodor, Zoltan Fehervari, Betty Diamond, Shimon Sakaguchi

JOURNAL OF LEUKOCYTE BIOLOGY　Vol. 81　No. 1　p. 161-167　2007/01　Research paper (scientific journal)

T cell self-reactivity forms a cytokine milieu for spontaneous development of IL-17(+) Th cells that cause autoimmune arthritis

Keiji Hirota, Motomu Hashimoto, Hiroyuki Yoshitomi, Satoshi Tanaka, Takashi Nomura, Tomoyuki Yamaguchi, Yoichiro Iwakura, Noriko Sakaguchi, Shimon Sakaguchi

JOURNAL OF EXPERIMENTAL MEDICINE　Vol. 204　No. 1　p. 41-47　2007/01　Research paper (scientific journal)

GITRL/GITR のCD4＋T 細胞機能への作用TNF ファミリーの分子リウマチ学－基礎から臨 床へ―

清水淳, 坂口志文

分子リウマチVol.4 No.4 2007（46－51）　2007

Spontaneous large-scale lymphoid neogenesis and balanced autoimmunity versus tolerance in the stomach of H+/K+-ATPase-Reactive TCR transgenic mouse

Tomoya Katakai, Takashi Nomura, Hiroyuki Gonda, Manabu Sugai, Yasutoshi Agata, Akiyoshi Nishio, Tohru Masuda, Shimon Sakaguchi, Akira Shimizu

JOURNAL OF IMMUNOLOGY　Vol. 177　No. 11　p. 7858-7867　2006/12　Research paper (scientific journal)

Glucocorticoid-induced tumour necrosis factor receptor family-related receptor signalling exacerbates hapten-induced colitis by CD4(+) T cells

Sun K. Lee, Beom K. Choi, Young H. Kim, Woo J. Kang, Kwang H. Kim, Shimon Sakaguchi, Jae H. Suh, Tae Y. Kim, Byoung S. Kwon

IMMUNOLOGY　Vol. 119　No. 4　p. 479-487　2006/12　Research paper (scientific journal)

A role for Dicer in immune regulation

Bradley S. Cobb, Arnulf Hertweck, James Smith, Eric O'Connor, Daniel Graf, Terence Cook, Stephen T. Smale, Shimon Sakaguchi, Frederick J. Livesey, Amanda G. Fisher, Matthias Merkenschlager

Journal of Experimental Medicine　Vol. 203　No. 11　p. 2519-2527　2006/10　Research paper (scientific journal)

Cytokine production profile of splenocytes derived from zymosan A-treated SKG mice developing arthritis

K. Kobayashi, T. Suda, K. Nan-ya, N. Sakaguchi, S. Sakaguchi, I. Miki

Inflammation Research　Vol. 55　No. 8　p. 335-341　2006/08　Research paper (scientific journal)

Foxp3(+)CD25(+)CD4(+) natural regulatory T cells in dominant self-tolerance and autoimmune disease

Shimon Sakaguchi, Masahiro Ono, Ruka Setoguchi, Haruhiko Yagi, Shohei Hori, Zoltan Fehervari, Jun Shimizu, Takeshi Takahashi, Takashi Nomura

IMMUNOLOGICAL REVIEWS　Vol. 212　p. 8-27　2006/08

Foxp3-dependent and -independent molecules specific for CD25(+)CD4(+) natural regulatory T cells revealed by DNA microarray analysis

Naoshi Sugimoto, Takatoku Oida, Keiji Hirota, Kyoko Nakamura, Takashi Nomura, Takashi Uchiyama, Shimon Sakaguchi

INTERNATIONAL IMMUNOLOGY　Vol. 18　No. 8　p. 1197-1209　2006/08　Research paper (scientific journal)

Delineation of immunoregulatory properties of adult T-cell leukemia cells

Yasushi Matsubara, Toshiyuki Hori, Rimpei Morita, Shimon Sakaguchi, Takashi Uchiyama

International Journal of Hematology　Vol. 84　No. 1　p. 63-69　2006/07　Research paper (scientific journal)

Glucocorticoid-induced TNF receptor family related gene activation overcomes tolerance/ignorance to melanoma differentiation antigens and enhances antitumor immunity

Teresa Ramirez-Montagut, Andrew Chow, Daniel Hirschhorn-Cymerman, Theis H. Terwey, Adam A. Kochman, Sydney Lu, Randy C. Miles, Shimon Sakaguchi, Alan N. Houghton, Marcel R. M. Van Den Brink

Journal of Immunology　Vol. 176　No. 11　p. 6434-6442　2006/06/01　Research paper (scientific journal)

CD4+CD25+Foxp3+ T cells and CD4 +CD25-Foxp3+ T cells in aged mice

Tomohisa Nishioka, Jun Shimizu, Ryuji Iida, Sayuri Yamazaki, Shimon Sakaguchi

Journal of Immunology　Vol. 176　No. 11　p. 6586-6593　2006/06/01　Research paper (scientific journal)

Agonist anti-GITR antibody enhances vaccine-induced CD8+ T-cell responses and tumor immunity

Adam D. Cohen, Adi Diab, Miguel-Angel Perales, Jedd D. Wolchok, Gabrielle Rizzuto, Taha Merghoub, Deonka Huggins, Cailian Liu, Mary Jo Turk, Nicholas P. Restifo, Shimon Sakaguchi, Alan N. Houghton

Cancer Research　Vol. 66　No. 9　p. 4904-4912　2006/05/01　Research paper (scientific journal)

Conversion of alloantigen-specific CD8(+) T cell anergy to CD8(+) T cell priming through in vivo ligation of glucocorticoid-induced TNF receptor

Juyang Kim, Woon S. Choi, Hyun Kang, Hye J. Kim, Jae-Hee Suh, Shimon Sakaguchi, Byungsuk Kwon

JOURNAL OF IMMUNOLOGY　Vol. 176　No. 9　p. 5223-5231　2006/05　Research paper (scientific journal)

Control of autoimmune myocarditis and multiorgan inflammation by glucocorticoid-induced TNF receptor family-related protein high, Foxp3-expressing CD25(+) and CD25(-) regulatory T cells

M Ono, J Shimizu, Y Miyachi, S Sakaguchi

JOURNAL OF IMMUNOLOGY　Vol. 176　No. 8　p. 4748-4756　2006/04　Research paper (scientific journal)

Autoimmunity

Jean-François Bach, Shimon Sakaguchi

Current Opinion in Immunology　Vol. 17　No. 6　p. 567-569　2005/12　Research paper (scientific journal)

関節炎を自然発症するSKGマウスにおける抗シトルリン化蛋白抗体産生の検討

橋本 求, 吉冨 啓之, 田中 聡, 廣田 圭司, 野村 尚史, 坂口 教子, 三森 経世, 坂口 志文

日本免疫学会総会・学術集会記録　Vol. 35　p. 244-244　2005/11

Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3+CD25+CD4+ regulatory T cells

Kuibeom Ko, Sayuri Yamazaki, Kyoko Nakamura, Tomohisa Nishioka, Keiji Hirota, Tomoyuki Yamaguchi, Jun Shimizu, Takashi Nomura, Tsutomu Chiba, Shimon Sakaguchi

Journal of Experimental Medicine　Vol. 202　No. 7　p. 885-891　2005/10/03　Research paper (scientific journal)

関節炎を自然発症するSKGマウスにおける抗シトルリン化蛋白抗体産生の検討

橋本 求, 吉冨 啓之, 田中 聡, 廣田 圭司, 野村 尚史, 坂口 教子, 三森 経世, 坂口 志文

日本臨床免疫学会会誌　Vol. 28　No. 4　p. 264-264　2005/08

Analysis of the underlying cellular mechanisms of anti-CD154-induced graft tolerance: The interplay of clonal anergy and immune regulation

Sergio A. Quezada, Kathy Bennett, Bruce R. Blazar, Alexander Y. Rudensky, Shimon Sakaguchi, Randolph J. Noelle

Journal of Immunology　Vol. 175　No. 2　p. 771-779　2005/07/15　Research paper (scientific journal)

Regulatory T cells, derived from naïve CD4+CD25- T cells by in vitro Foxp3 gene transfer, can induce transplantation tolerance

Jian-Guo Chai, Shao-An Xue, David Coe, Caroline Addey, Istvan Bartok, Diane Scott, Elizabeth Simpson, Hans J. Stauss, Shohei Hori, Shimon Sakaguchi, Julian Dyson

Transplantation　Vol. 79　No. 10　p. 1310-1316　2005/05/27　Research paper (scientific journal)

Extracellular signal-dependent nuclear import of STAT3 is mediated by various importin alpha s

R Ushijima, N Sakaguchi, A Kano, A Maruyama, Y Miyamoto, T Sekimoto, Y Yoneda, K Ogino, T Tachibana

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 330　No. 3　p. 880-886　2005/05　Research paper (scientific journal)

Regulatory T cells in autoimmune diseases: Preface

Shimon Sakaguchi

International Reviews of Immunology　Vol. 24　No. 3-4　p. 157-158　2005/05　Research paper (scientific journal)

A role for fungal β-glucans and their receptor Dectin-1 in the induction of autoimmune arthritis in genetically susceptible mice

Hiroyuki Yoshitomi, Noriko Sakaguchi, Katsuya Kobayashi, Gordon D. Brown, Tomoyuki Tagami, Toshiko Sakihama, Keiji Hirota, Satoshi Tanaka, Takashi Nomura, Ichiro Miki, Siamon Gordon, Shizuo Akira, Takashi Nakamura, Shimon Sakaguchi

Journal of Experimental Medicine　Vol. 201　No. 6　p. 949-960　2005/03/21　Research paper (scientific journal)

Definition of target antigens for naturally occurring CD4+ CD25+ regulatory T cells

Hiroyoshi Nishikawa, Takuma Kato, Isao Tawara, Kanako Saito, Hiroaki Ikeda, Kagemasa Kuribayashi, Paul M. Allen, Robert D. Schreiber, Shimon Sakaguchi, Lloyd J. Old, Hiroshi Shiku

Journal of Experimental Medicine　Vol. 201　No. 5　p. 681-686　2005/03/07　Research paper (scientific journal)

Homeostatic maintenance of natural Foxp3+ CD25+ CD4+ regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization

Ruka Setoguchi, Shohei Hori, Takeshi Takahashi, Shimon Sakaguchi

Journal of Experimental Medicine　Vol. 201　No. 5　p. 723-735　2005/03/07　Research paper (scientific journal)

Development of autoimmunity against transcriptionally unrepressed target antigen in the thymus of Aire-deficient mice.

Noriyuki Kuroda, Tasuku Mitani, Naoki Takeda, Naozumi Ishimaru, Rieko Arakaki, Yoshio Hayashi, Yoshimi Bando, Keisuke Izumi, Takeshi Takahashi, Takashi Nomura, Shimon Sakaguchi, Tomoo Ueno, Yousuke Takahama, Daisuke Uchida, Shijie Sun, Fumiko Kajiura, Yasuhiro Mouri, Hongwei Han, Akemi Matsushima, Gen Yamada, Mitsuru Matsumoto

Journal of immunology (Baltimore, Md. : 1950)　Vol. 174　No. 4　p. 1862-70　2005/02/15　Research paper (scientific journal)

Cutting edge: Contact-mediated suppression by CD4+CD25 + regulatory cells involves a granzyme B-dependent, perforin-independent mechanism

David C. Gondek, Li-Fan Lu, Sergio A. Quezada, Shimon Sakaguchi, Randolph J. Noelle

Journal of Immunology　Vol. 174　No. 4　p. 1783-1786　2005/02/15　Research paper (scientific journal)

Phenotypic and functional relationship between adult T-cell leukemia cells and regulatory T cells

Yasushi Matsubara, Toshiyuki Hori, Rimpei Morita, Shimon Sakaguchi, Takashi Uchiyama

Leukemia　Vol. 19　No. 3　p. 482-483　2005/01/13　Research paper (scientific journal)

SKG mice as a model of RA

H. Yoshitomi, S. Sakaguchi

Nippon rinsho. Japanese journal of clinical medicine　Vol. 63 Suppl 1　p. 40-45　2005

Regulatory T: Cells

Zoltán Fehérvari, Shimon Sakaguchi

Measuring Immunity: Basic Biology and Clinical Assessment　p. 322-335　2005　Part of collection (book)

Regulatory T cell and autoimmune diseases

Satoshi Tanaka, Shimon Sakaguchi

Japanese Journal of Clinical Immunology　Vol. 28　No. 5　p. 291-299　2005　Research paper (scientific journal)

内在性制御性T 細胞と自己免疫疾患医学のあゆみ

瀬戸口留可, 坂口志文

2005 Vol. 213 No. 1（69－73）　2005

IL - 2 and autoimmunity : homeostatic maintenance of CD25＋4＋ regulatory T cells via IL - 2 secreted by other T cells and induction of autoimmune desease by IL - 2 neutralization.

Ruka Setoguchi, Shohei Hori, Takeshi Takahashi, Shimon Sakaguchi

Keystone Symposia Cellular Senescence and Cell Death（2005 3. 3－8. Colorado,USA）　2005

Generation of autoaggresive CD4＋ T cells due to a ZAP-70 point mutation in SKG mice that spontaneous develop autoimmune arthritis.

Keiji Hirota, Hiroyuki Yoshitomi, Satoshi Tanaka, Takashi Nomura, Noriko Sakaguchi, Shimon Sakaguchi

Keystone Symposia Cellular Senescence and Cell Death（2005 3. 3－8. Colorado, USA）　2005

Control of Foxp3+ CD25+CD4+ regulatory cell activation and function by dendritic cells

Zoltán Fehérvári, Shimon Sakaguchi

International Immunology　Vol. 16　No. 12　p. 1769-1780　2004/12　Research paper (scientific journal)

Analyses of peripheral blood mononuclear cells in operational tolerance after pediatric living donor liver transplantation

Ying Li, Takaaki Koshiba, Atsushi Yoshizawa, Yukihide Yonekawa, Kosuke Masuda, Atsushi Ito, Mikiko Ueda, Takahide Mori, Hiroshi Kawamoto, Yoshimasa Tanaka, Shimon Sakaguchi, Nagahiro Minato, Kathryn J. Wood, Koichi Tanaka

American Journal of Transplantation　Vol. 4　No. 12　p. 2118-2125　2004/12　Research paper (scientific journal)

遺伝性自己免疫疾患の原因遺伝子AIRE(autoimmune regulator)の機能解析

松本 満, 黒田 範行, 石丸 直澄, 新垣 理恵子, 林 良夫, 野村 尚史, 坂口 志文, 上野 智雄, 高浜 洋介, 松島 明美

日本免疫学会総会・学術集会記録　Vol. 34　p. 77-77　2004/11

Reduction of retrovirus-induced immunosuppression by in vivo modulation of T cells during acute infection

Hong He, Ronald J. Messer, Shimon Sakaguchi, Guojun Yang, Shelly J. Robertson, Kim J. Hasenkrug

Journal of Virology　Vol. 78　No. 21　p. 11641-11647　2004/11　Research paper (scientific journal)

Murine autoimmune arthritis due to a spontaneous mutation of the ZAP-70 gene

SAKAGUCHI Noriko, NOMURA Takashi, SAKAGUCHI Shimon

Nihon Rinsho Men'eki Gakkai Sokai Shorokushu　Vol. 27　No. 4　p. 222-222　2004/08/31

Induction of antigen-specific immunologic tolerance by in vivo and in vitro antigen-specific expansion of naturally arising Foxp3+ CD25+ CD4+ regulatory T cells

Eiji Nishimura, Toshiko Sakihama, Ruka Setoguchi, Koichi Tanaka, Shimon Sakaguchi

International Immunology　Vol. 16　No. 8　p. 1189-1201　2004/08　Research paper (scientific journal)

Distinct contribution of IL-6, TNF-α, IL-1, and IL-10 to T cell-mediated spontaneous autoimmune arthritis in mice

Hiroshi Hata, Noriko Sakaguchi, Hiroyuki Yoshitomi, Yoichiroh Iwakura, Kenji Sekikawa, Yoshiaki Azuma, Chieko Kanai, Eiko Moriizumi, Takashi Nomura, Takashi Nakamura, Shimon Sakaguchi

Journal of Clinical Investigation　Vol. 114　No. 4　p. 582-588　2004/08　Research paper (scientific journal)

GITR activation induces an opposite effect on alloreactive CD4+ and CD8+ T cells in graft-versus-host disease

Stephanie J. Muriglan, Teresa Ramirez-Montagut, Onder Alpdogan, Thomas W. Van Huystee, Jeffrey M. Eng, Vanessa M. Hubbard, Adam A. Kochman, Kartono H. Tjoe, Carlo Riccardi, Pier Paolo Pandolfi, Shimon Sakaguchi, Alan N. Houghton, Marcel R.M. Van Den Brink

Journal of Experimental Medicine　Vol. 200　No. 2　p. 149-157　2004/07/19　Research paper (scientific journal)

CD25+CD4+ T cells in human cord blood: An immunoregulatory subset with naive phenotype and specific expression of forkhead box p3 (Foxp3) gene

Yasushi Takahata, Akihiko Nomura, Hidetoshi Takada, Shouichi Ohga, Kenji Furuno, Shunji Hikino, Hideki Nakayama, Shimon Sakaguchi, Toshiro Hara

Experimental Hematology　Vol. 32　No. 7　p. 622-629　2004/07　Research paper (scientific journal)

Costimulation via glucocorticoid-induced TNF receptor in both conventional and CD25+ regulatory CD4+ T cells

Fumiko Kanamaru, Pornpan Youngnak, Masaaki Hashiguchi, Tomohisa Nishioka, Takeshi Takahashi, Shimon Sakaguchi, Isao Ishikawa, Miyuki Azuma

Journal of Immunology　Vol. 172　No. 12　p. 7306-7314　2004/06/15　Research paper (scientific journal)

4-1BB-dependent inhibition of immunosuppression by activated CD4 +CD25+ T cells

Beom K. Choi, Jun S. Bae, Eun M. Choi, Woo J. Kang, Shimon Sakaguchi, Dass S. Vinay, Byoung S. Kwon

Journal of Leukocyte Biology　Vol. 75　No. 5　p. 785-791　2004/05　Research paper (international conference proceedings)

Functional impairment of CD8+ T cells by regulatory T cells during persistent retroviral infection

Ulf Dittmer, Hong He, Ronald J. Messer, Simone Schimmer, Anke R.M. Olbrich, Claes Ohlen, Philip D. Greenberg, Ingunn M. Stromnes, Michihiro Iwashiro, Shimon Sakaguchi, Leonard H. Evans, Karin E. Peterson, Guojun Yang, Kim J. Hasenkrug

Immunity　Vol. 20　No. 3　p. 293-303　2004/03　Research paper (scientific journal)

NF-κB-Inducing Kinase Establishes Self-Tolerance in A Thymic Stroma-Dependent Manner

Fumiko Kajiura, Shijie Sun, Takashi Nomura, Keisuke Izumi, Tomoo Ueno, Yoshimi Bando, Noriyuki Kuroda, Hongwei Han, Yi Li, Akemi Matsushima, Yousuke Takahama, Shimon Sakaguchi, Tasuku Mitani, Mitsuru Matsumoto

Journal of Immunology　Vol. 172　No. 4　p. 2067-2075　2004/02/15　Research paper (scientific journal)

Regulation of autoimmune diabetes by non-islet-specific T cells - A role for the glucocorticoid-induced TNF receptor

Anish Suri, Jun Shimizu, Jonathan D. Katz, Shimon Sakaguchi, Emil R. Unanue, Osami Kanagawa

European Journal of Immunology　Vol. 34　No. 2　p. 447-454　2004/02　Research paper (scientific journal)

IL-10 is involved in the suppression of experimental autoimmune encephalomyelitis by CD25+CD4+ regulatory T cells

Xingmin Zhang, Djordje N. Koldzic, Leonid Izikson, Jayagopala Reddy, Remedios F. Nazareno, Shimon Sakaguchi, Vijay K. Kuchroo, Howard L. Weiner

International Immunology　Vol. 16　No. 2　p. 249-256　2004/02　Research paper (scientific journal)

Altered thymic T-cell selection due to a spontaneous mutation of the ZAP-70 gene causes autoimmune arthritis

N Sakaguchi, T Takahashi, H Hata, T Nomura, T Tagami, S Yamazaki, T Sakihama, Negishi, I, S Nakatsuru, S Sakaguchi

IMMUNOLOGY 2004: AUTOIMMUNITY, GENETIC AND DEGENERATIVE DISORDERS, MALIGNANCIES, AND TRANSPLANTATION　p. 239-242　2004　Research paper (international conference proceedings)

Induction of fatal autoimmune myocarditis and other autoimmune diseases in mice by depleting Foxp3-expressing T cells

M Ono, J Shimizu, Y Miyachi, S Sakaguchi

IMMUNOLOGY 2004: AUTOIMMUNITY, GENETIC AND DEGENERATIVE DISORDERS, MALIGNANCIES, AND TRANSPLANTATION　p. 193-195　2004　Research paper (international conference proceedings)

Crucial role of FOXP3 in the development of human CD25＋4＋ regulatory T cells.

Haruhiko Yagi, Takashi Nomura, Kyoko Nakamura, Toshio Kitawaki, Masafumi Onodera, Takashi Uchiyama, Shingo Fujii, Shimon Sakaguchi

Keystone Symposia Regulatory/Suppressor T Cells（2004.3.10－15. Banff Canada）　2004

Tumor Immunotherapy with anti GITR monoclonal antibody in mice.

Keiji Hirota, Kwibeom Ko, Sayuri Yamazaki, Jun Shimizu, Kyoko Nakamura, Tomoyuki Yamaguchi, Takashi Nomura, Shimon Sakaguchi

Keystone Symposia Regulatory/Suppressor T Cells（2004.3.10－15. Banff Canada）　2004

Neutralization of IL-2 breaks immunological self-tolerance by reducing the \nnumber of CD25＋4＋regulatory T cells.

Ruka Setoguchi, Shimon Sakaguchi

Keystone Symposia Regulatory/Suppressor T Cells（2004.3.10－15. Banff Canada）　2004

Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice

Noriko Sakaguchi, Takeshi Takahashi, Hiroshi Hata, Takashi Nomura, Tomoyuki Tagami, Sayuri Yamazaki, Toshiko Sakihama, Takaji Matsutani, Izumi Negishi, Syuichi Nakatsuru, Shimon Sakaguchi

Nature　Vol. 426　No. 6965　p. 454-460　2003/11/27　Research paper (scientific journal)

Control of regulatory T cell development by the transcription factor Foxp3

Shohei Hori, Takashi Nomura, Shimon Sakaguchi

Science　Vol. 299　No. 5609　p. 1057-1061　2003/02/14　Research paper (scientific journal)

Regulatory T cells: Mediating compromises between host and parasite

Shimon Sakaguchi

Nature Immunology　Vol. 4　No. 1　p. 10-11　2003/01/01　Research paper (scientific journal)

T細胞機能異常による自己免疫性関節炎の発症

坂口 教子, 坂口 志文

日本臨床免疫学会会誌 = Japanese journal of clinical immunology　Vol. 25　No. 1　p. 62-62　2002/02/28

Stimulation of CD25+CD4+ regulatory T cells through GITR breaks immunological self-tolerance

Jun Shimizu, Sayuri Yamazaki, Takeshi Takahashi, Yasumasa Ishida, Shimon Sakaguchi

Nature Immunology　Vol. 3　No. 2　p. 135-142　2002　Research paper (scientific journal)

Increased T cell autoreactivity in the absence of CD40-CD40 ligand interactions: A role of CD40 in regulatory T cell development

A. Kumanogoh, X. Wang, I. Lee, C. Watanabe, M. Kamanaka, W. Shi, K. Yoshida, T. Sato, S. Habu, M. Itoh, N. Sakaguchi, S. Sakaguchi, H. Kikutani

Journal of Immunology　Vol. 166　No. 1　p. 353-360　2001/01/01　Research paper (scientific journal)

Immunologic tolerance maintained by CD25+ CD4+ regulatory T cells: Their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance

Shimon Sakaguchi, Noriko Sakaguchi, Jun Shimizu, Sayuri Yamazaki, Toshiko Sakihama, Misako Itoh, Yuhshi Kuniyasu, Takashi Nomura, Masaaki Toda, Takeshi Takahashi

Immunological Reviews　Vol. 182　p. 18-32　2001

Immunologic self tolerance maintained by T-cell-mediated control of self-reactive T cells: Implications for autoimmunity and tumor immunity

Shimon Sakaguchi, Takeshi Takahashi, Sayuri Yamazaki, Yuhshi Kuniyasu, Misako Itoh, Noriko Sakaguchi, Jun Shimizu

Microbes and Infection　Vol. 3　No. 11　p. 911-918　2001

リウマチ様関節炎自然発症マウスモデルにおける遺伝因子・環境因子の役割

坂口 教子, 坂口 志文

日本臨床免疫学会会誌 = Japanese journal of clinical immunology　Vol. 22　No. 6　p. 491-491　1999/12/31

Breaking Immunologic Tolerance to Tumor Cells As a Novel Immunotherapy for Cancer

Shimon Sakaguchi, Jun Shimizu

Keio Journal of Medicine　Vol. 48　p. A7-A12　1999　Research paper (scientific journal)

CD25^+T細胞による自己寛容の維持機構とその破綻による自己免疫病の発症

高橋 武司, 国安 裕史, 清水 淳, 坂口 志文

日本臨床免疫学会会誌 = Japanese journal of clinical immunology　Vol. 20　No. 6　p. 506-506　1997/12/31

IMMUNOLOGICAL PROPERTIES OF FC RECEPTOR ON LYMPHOCYTES .10. ANTIGEN-SPECIFIC FCR-GAMMA-T AND ANTIGEN-NONSPECIFIC FCR-GAMMA+T SUPPRESSORS IN IMMUNE TOLERANCE

K USAMI, M MIYAMAINABA, K KURIBAYASHI, S SAKAGUCHI, M HANAOKA, T MASUDA

ACTA HAEMATOLOGICA JAPONICA　Vol. 45　No. 4　p. 772-784　1982　Research paper (scientific journal)