Researcher Directory - Osaka University

Tsutsumi Yasuo

堤　康央

Graduate School of Pharmaceutical Sciences　Advanced Pharmaco-science, Professor

keyword Drug Therapeutics，Biopharmaceutics，Drug Delivery System

Research Areas

Life sciences, Clinical pharmacy
Life sciences, Pharmaceuticals - chemistry and drug development
Life sciences, Pharmacology
Life sciences, Pharmaceuticals - health and biochemistry
Life sciences, Biomaterials
Life sciences, Biomedical engineering

Professional Memberships

日本食品衛生学会
日本香粧品学会
日本免疫毒性学会
日本トキシコロジー学会
日本免疫学会
日本DDS学会
日本癌学会
日本薬学会

Papers

Coculture with macrophages alters ferroptosis susceptibility of triple-negative cancer cells, Hiroto Konishi,Yuya Haga,Moe Okumura,Hirofumi Tsujino,Kazuma Higashisaka,Yasuo Tsutsumi, Cell Death Discovery, Springer Science and Business Media LLC, Vol. 10, No. 1, 2024/03/01
劣化したマイクロプラスチックが示す細胞毒性機序の解明, Yuya Haga,Sota Manabe,Hirofumi Tsujino,Haruyasu Asahara,Kazuma Higashisaka,Yasuo Tsutsumi, YAKUGAKU ZASSHI, Pharmaceutical Society of Japan, Vol. 144, No. 2, p. 177-181, 2024/02/01
環境中の表面性状を模倣した劣化マイクロプラスチックの作製, Hirofumi Tsujino,Yudai Ikuno,Yuya Haga,Haruyasu Asahara,Kazuma Higashisaka,Yasuo Tsutsumi, YAKUGAKU ZASSHI, Pharmaceutical Society of Japan, Vol. 144, No. 2, p. 171-175, 2024/02/01
Valproic acid elevates HIF-1α-mediated CGB expression and suppresses glucose uptake in BeWo cells., Go Kitahara,Kazuma Higashisaka,Yurina Nakamoto,Rena Yamamoto,Wakako Okuno,Momoe Serizawa,Yuji Sakahashi,Hirofumi Tsujino,Yuya Haga,Yasuo Tsutsumi, The Journal of toxicological sciences, Vol. 49, No. 2, p. 69-77, 2024
L858R emerges as a potential biomarker predicting response of lung cancer models to anti-EGFR antibodies: Comparison of osimertinib vs. cetuximab, Ilaria Marrocco,Suvendu Giri,Arturo Simoni-Nieves,Nitin Gupta,Anna Rudnitsky,Yuya Haga,Donatella Romaniello,Arunachalam Sekar,Mirie Zerbib,Roni Oren,Moshit Lindzen,Damon Fard,Yasuo Tsutsumi,Mattia Lauriola,Luca Tamagnone,Yosef Yarden, Cell Reports Medicine, Elsevier BV, p. 101142-101142, 2023/08
Evidence-Based Prediction of Cellular Toxicity for Amorphous Silica Nanoparticles, Martin,Reiko Watanabe,Kosuke Hashimoto,Kazuma Higashisaka,Yuya Haga,Yasuo Tsutsumi,Kenji Mizuguchi, ACS Nano, 2023/05/30
Impact of Degradation of Polyethylene Particles on Their Cytotoxicity, Yudai Ikuno,Hirofumi Tsujino,Yuya Haga,Haruyasu Asahara,Kazuma Higashisaka,Yasuo Tsutsumi, Microplastics, MDPI AG, Vol. 2, No. 2, p. 192-201, 2023/05/22
Fluorouracil exacerbates alpha-crystallin B chain-mediated cell migration in triple-negative breast cancer cell lines., Lili Yang,Yuya Haga,Akihide Nishimura,Yuki Tsujii,Suzuno Tanahashi,Hirofumi Tsujino,Kazuma Higashisaka,Yasuo Tsutsumi, Scientific reports, Vol. 13, No. 1, p. 4010-4010, 2023/03/10
Chloroquine is a safe autophagy inhibitor for sustaining the expression of antioxidant enzymes in trophoblasts, Atsushi Furuta,Tomoko Shima,Mihoko Yoshida-Kawaguchi,Kiyotaka Yamada,Ippei Yasuda,Sayaka Tsuda,Akemi Yamaki-Ushijima,Satoshi Yoneda,Kazuma Higashisaka,Shi-Bin Cheng,Kenji Matsumoto,Yasuo Tsutsumi,Surendra Sharma,Shigeru Saito,Akitoshi Nakashima, Journal of Reproductive Immunology, Elsevier BV, Vol. 155, p. 103766-103766, 2023/02
Silver nanoparticles suppress forskolin-induced syncytialization in BeWo cells, Yuji Sakahashi,Kazuma Higashisaka,Ryo Isaka,Rina Izutani,Jiwon Seo,Atsushi Furuta,Akemi Yamaki-Ushijima,Hirofumi Tsujino,Yuya Haga,Akitoshi Nakashima,Yasuo Tsutsumi, Nanotoxicology, Informa UK Limited, p. 1-12, 2023/01/03
Absorption, fluorescence, and two-photon excitation ability of 5-phenyl-13-arylisoindolo[2,1-a]quinolines prepared by one-pot reaction of ring-closing metathesis and 1,3-dipolar cycloaddition, Avena Francisco Ramon,Yuki Wada,Hirokazu Ishii,Yuki Watakabe,Motosuke Tsutsumi,Kwangkyun Jang,Kohei Otomo,Lin Qiao,Yuki Fujii,Hirofumi Tsujino,Yasuo Tsutsumi,Tomomi Nemoto,Mitsuhiro Arisawa, Dyes and Pigments, Elsevier BV, p. 111118-111118, 2023/01
Silver Nanoparticles Suppress Retinoic Acid-Induced Neuronal Differentiation in Human-Derived Neuroblastoma SH-SY5Y Cells, Shintaro Yamaguchi,Ryo Isaka,Yuji Sakahashi,Hirofumi Tsujino,Yuya Haga,Kazuma Higashisaka,Yasuo Tsutsumi, ACS Applied Nano Materials, American Chemical Society (ACS), Vol. 5, No. 12, p. 19025-19034, 2022/12/23
Osimertinib-tolerant lung cancer cells are susceptible to ferroptosis., Hiroto Konishi,Yuya Haga,Ying Lin,Hirofumi Tsujino,Kazuma Higashisaka,Yasuo Tsutsumi, Biochemical and biophysical research communications, Vol. 641, p. 116-122, 2022/12/10
Identification of biomarkers of chronic kidney disease among kidney-derived proteins, Kazuma Higashisaka,Sonoko Takeya,Haruhiko Kamada,Masanori Obana,Makiko Maeda,Mai Kabayama,Koichi Yamamoto,Nanan Ishida,Ryo Isaka,Hirofumi Tsujino,Kazuya Nagano,Noriyuki Tomiyama,Hiromi Rakugi,Yasushi Fujio,Kei Kamide,Yasuo Tsutsumi, Clinical Proteomics, Springer Science and Business Media LLC, Vol. 19, No. 1, p. 3-3, 2022/12
The Autophagy-Lysosomal Machinery Enhances Cytotrophoblast–Syncytiotrophoblast Fusion Process, Atsushi Furuta,Tomoko Shima,Mihoko Kawaguchi,Akemi Yamaki-Ushijima,Ippei Yasuda,Sayaka Tsuda,Satoshi Yoneda,Kazuma Higashisaka,Shi-Bin Cheng,Kenji Matsumoto,Yasuo Tsutsumi,Surendra Sharma,Shigeru Saito,Akitoshi Nakashima, Reproductive Medicine, MDPI AG, Vol. 3, No. 2, p. 112-126, 2022/05/05
Amorphous silica nanoparticles (nSP50) exacerbate hepatic damage through the activation of acquired cell-mediated immunity, Shun-ichi Eto,Kazuma Higashisaka,Aoi Koshida,Kenta Sato,Mao Ogura,Miyuki Sakurai,Hirofumi Tsujino,Kazuya Nagano,Yasuo Tsutsumi, Nano Express, IOP Publishing, Vol. 3, No. 1, p. 015002-015002, 2022/03/01
Alpha-crystallin B chains enhance cell migration in basal-like 2 triple-negative breast cancer cells., Yang L,Higashisaka K,Haga Y,Tsujino H,Nagano K,Tsutsumi Y, Pharmazie, AVOXA-MEDIENGRUPPE DEUTSCHER APOTHEKER GMBH, Vol. 77, No. 2, p. 45-17, 2022/02
Amorphas Silica Nanoparticles Decrease Human Chorionic Gonadotropin β Expression During Syncytialization of BeWo Cell, Yuji Sakahashi,Rena Yamamoto,Go Kitahara,Rina Izutani,Hirofumi Tsujino,Yuya Haga,Kazuma Higashisaka,Yasuo Tsutsumi, BPB Reports, Pharmaceutical Society of Japan, Vol. 5, No. 6, p. 154-158, 2022
Silica Particles with Human Protein Corona Shows Sensitization Potential in the Human Cell Line Activation Test, Shun-ichi Eto,Aoi Koshida,Hirofumi Tsujino,Kazuya Nagano,Kazuma Higashisaka,Yasuo Tsutsumi, BPB Reports, Pharmaceutical Society of Japan, Vol. 5, No. 1, p. 1-4, 2022/01
Subvisible Particles Derived by Dropping Stress Enhance Anti-PEG Antibody Production and Clearance of PEGylated Proteins in Mice, Takaki Nakajima,Kazuya Nagano,Yuka Fukuda,Yu Ishima,Hiroko Shibata,Ryo Isaka,Tian-qi Zhang,Yuya Haga,Kazuma Higashisaka,Hirofumi Tsujino,Tatsuhiro Ishida,Akiko Ishii-Watabe,Yasuo Tsutsumi, Journal of Pharmaceutical Sciences, Elsevier BV, 2022/01
Alpha-crystallin B chains in trastuzumab-resistant breast cancer cells promote endothelial cell tube formation through activating mTOR, Lili Yang,Kazuma Higashisaka,Masafumi Shimoda,Yuya Haga,Naoki Sekine,Hirofumi Tsujino,Kazuya Nagano,Kenzo Shimazu,Yasuo Tsutsumi, Biochemical and Biophysical Research Communications, Elsevier BV, Vol. 588, p. 175-181, 2022/01
Subvisible Particles Derived by Dropping Stress Enhance Anti-PEG Antibody Production and Clearance of PEGylated Proteins in Mice, Takaki Nakajima,Kazuya Nagano,Yuka Fukuda,Yu Ishima,Hiroko Shibata,Ryo Isaka,Tian-qi Zhang,Yuya Haga,Kazuma Higashisaka,Hirofumi Tsujino,Tatsuhiro Ishida,Akiko Ishii-Watabe,Yasuo Tsutsumi, Journal of Pharmaceutical Sciences, Elsevier BV, Vol. 111, No. 5, p. 1363-1369, 2022/01
Progesterone receptor membrane component 2 expression leads to erlotinib resistance in lung adenocarcinoma cells, Hanamuro S,Lin Y,Konishi H,Izusawa K,Yang L,Haga Y,Tsujino H,Nagano K,Higashisaka K,Tsutsumi Y, Pharmazie, 2021/11
Carbon-Carbon Bond Formation between N-Heterocyclic Carbene Ligand on Ruthenium Carbene Catalysts and 1,4-Naphthoquinone via Intramolecular Carbon(sp(3))-Hydrogen Bond Activation, Yuki Wada,Tsunayoshi Takehara,Takeyuki Suzuki,Satoshi Aoki,Takayuki Hibi,Makoto Sako,Hirofumi Tsujino,Yasuo Tsutsumi,Mitsuhiro Arisawa, ORGANOMETALLICS, AMER CHEMICAL SOC, Vol. 40, No. 16, p. 2901-2908, 2021/08
Host-Dependent Phenotypic Resistance to EGFR Tyrosine Kinase Inhibitors, Yuya Haga,Ilaria Marrocco,Ashish Noronha,Mary Luz Uribe,Nishanth Belugali Nataraj,Arunachalam Sekar,Diana Drago-Garcia,Simone Borgoni,Moshit Lindzen,Suvendu Giri,Stefan Wiemann,Yasuo Tsutsumi,Yosef Yarden, Cancer Research, American Association for Cancer Research (AACR), Vol. 81, No. 14, p. 3862-3875, 2021/07/15
TSHZ2 is an EGF-regulated tumor suppressor that binds to the cytokinesis regulator PRC1 and inhibits metastasis, Mary L. Uribe,Maik Dahlhoff,Rajbir N. Batra,Nishanth B. Nataraj,Yuya Haga,Diana Drago-Garcia,Ilaria Marrocco,Arunachalam Sekar,Soma Ghosh,Itay Vaknin,Sacha Lebon,Lior Kramarski,Yasuo Tsutsumi,Inpyo Choi,Oscar M. Rueda,Carlos Caldas,Yosef Yarden, Science Signaling, American Association for the Advancement of Science (AAAS), Vol. 14, No. 688, p. eabe6156-eabe6156, 2021/06/22
Characterization of a TNFR2-Selective Agonistic TNF-α Mutant and Its Derivatives as an Optimal Regulatory T Cell Expander, Masaki Inoue,Kanako Yamashita,Yuta Tsuji,Midori Miki,Shota Amano,Taichi Okumura,Koki Kuge,Takao Tone,Shota Enomoto,Chinatsu Yoshimine,Yuki Morita,Daisuke Ando,Haruhiko Kamada,Norihisa Mikami,Yasuo Tsutsumi,Shin-ichi Tsunoda, The Journal of Immunology, The American Association of Immunologists, Vol. 206, No. 8, p. 1740-1751, 2021/04/15
Legislation on the Roles of the Pharmacist and Pharmacy in the Revision of the Pharmaceutical and Medical Device Act and the Pharmacists Act in Japan, Kento Takamura,Keisuke Tachibana,Tetsunari Kihira,Kiyohito Nakai,Yasuo Tsutsumi,Masuo Kondoh, Therapeutic Innovation & Regulatory Science, Springer Science and Business Media LLC, Vol. 55, No. 2, p. 304-308, 2021/03
Indoxyl Sulfate Induces an Inflammatory Response in the Proximal Tubule via Macrophages, Ryo Isaka,Nanan Ishida,Go Kitahara,Yuji Sakahashi,Yuya Haga,Hirofumi Tsujino,Kazuya Nagano,Kazuma Higashisaka,Yasuo Tsutsumi, BPB Reports, Pharmaceutical Society of Japan, Vol. 4, No. 6, p. 198-201, 2021
Oral intake of silica nanoparticles exacerbates intestinal inflammation, Takao Ogawa,Ryu Okumura,Kazuya Nagano,Tomomi Minemura,Masahiro Izumi,Daisuke Motooka,Shota Nakamura,Tetsuya Iida,Yuichi Maeda,Atsushi Kumanogoh,Yasuo Tsutsumi,Kiyoshi Takeda, Biochemical and Biophysical Research Communications, Elsevier BV, Vol. 534, p. 540-546, 2021/01
Inhibition of Akt/mTOR pathway overcomes intrinsic resistance to dasatinib in triple-negative breast cancer, Yuya Haga,Kazuma Higashisaka,Lili Yang,Naoki Sekine,Ying Lin,Hirofumi Tsujino,Kazuya Nagano,Yasuo Tsutsumi, Biochemical and Biophysical Research Communications, Elsevier BV, Vol. 533, No. 4, p. 672-678, 2020/12
Silver Nanoparticles Induce DNA Hypomethylation through Proteasome-Mediated Degradation of DNA Methyltransferase 1, Ayaka Maki,Ying Lin,Michihiko Aoyama,Kenta Sato,Jian-Qing Gao,Hirofumi Tsujino,Kazuya Nagano,Kazuma Higashisaka,Yasuo Tsutsumi, Biological and Pharmaceutical Bulletin, Pharmaceutical Society of Japan, Vol. 43, No. 12, p. 1924-1930, 2020/12/01
Development and Evaluation of a System for the Semi-Quantitative Determination of the Physical Properties of Skin After Exposure to Silver Nanoparticles, Hong Tao,Kazuya Nagano,Ikkei Tasaki,Tian-qi Zhang,Takuya Ishizaka,Jian-Qing Gao,Kazuo Harada,Kazumasa Hirata,Hirofumi Tsujino,Kazuma Higashisaka,Yasuo Tsutsumi, Nanoscale Research Letters, Springer Science and Business Media LLC, Vol. 15, No. 1, p. 187-187, 2020/12
Progesterone receptor membrane component 1 leads to erlotinib resistance, initiating crosstalk of Wnt/β-catenin and NF-κB pathways, in lung adenocarcinoma cells, Ying Lin,Kazuma Higashisaka,Takuya Shintani,Ayaka Maki,Sachiyo Hanamuro,Yuya Haga,Shinichiro Maeda,Hirofumi Tsujino,Kazuya Nagano,Yasushi Fujio,Yasuo Tsutsumi, Scientific Reports, Springer Science and Business Media LLC, Vol. 10, No. 1, p. 4748-4748, 2020/12
The Roadmap to Approval under Japan’s Two-Track Regulatory System: Comparing Six Regenerative Medical Products, Shunsuke Matsushita,Keisuke Tachibana,Tetsuya Kusakabe,Ryuichi Hirayama,Yasuo Tsutsumi,Masuo Kondoh, Cell Stem Cell, Elsevier BV, Vol. 27, No. 4, p. 515-518, 2020/10
Structural optimization of a TNFR1-selective antagonistic TNFα mutant to create new-modality TNF-regulating biologics, Masaki Inoue,Yuta Tsuji,Chinatsu Yoshimine,Shota Enomoto,Yuki Morita,Natsuki Osaki,Masahiro Kunishige,Midori Miki,Shota Amano,Kanako Yamashita,Haruhiko Kamada,Yasuo Tsutsumi,Shin-ichi Tsunoda, Journal of Biological Chemistry, Elsevier BV, Vol. 295, No. 28, p. 9379-9391, 2020/07
New Japanese Regulatory Frameworks for Post-Marketing Management of Pharmaceutical Products., Kento Takamura,Keisuke Tachibana,Tetsuya Kusakabe,Kiyohito Nakai,Yasuo Tsutsumi,Masuo Kondoh, Pharmaceutical research, Vol. 37, No. 7, p. 122-122, 2020/06/08
Development and evaluation of a simultaneous and efficient quantification strategy for final prostanoid metabolites in urine, Tian-qi Zhang,Hirotaka Kuroda,Kazuya Nagano,Soshi Terada,Jian-Qing Gao,Kazuo Harada,Kazumasa Hirata,Hirofumi Tsujino,Kazuma Higashisaka,Hiroshi Matsumoto,Yasuo Tsutsumi, Prostaglandins, Leukotrienes and Essential Fatty Acids, Elsevier BV, Vol. 157, p. 102032-102032, 2020/06
近位尿細管の上皮間葉転換においてインテグリンリガンドが果たす役割の解明, 井阪亮,東阪和馬,石田菜南,坂橋優治,山口慎太郎,北原剛,藤尾慈,神出計,辻野博文,長野一也,堤康央, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 140年会, p. 26F-pm11S, 2020/03
乳がん遠隔転移症例における尿中プロスタノイド代謝物量の解析, 張天斉,長野一也,黒田博隆,寺田壮志,原田和生,平田收正,辻野博文,東阪和馬,松本博志,堤康央, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 140年会, p. 27P-pm102S, 2020/03
Absorption, Fluorescence, and Two-Photon Excitation Ability of 5-Phenylisolidolo[2,1- a]quinolines, Ramon Francisco Avena,Lin Qiao,Yuki Fujii,Kohei Otomo,Hirokazu Ishii,Takeyuki Suzuki,Hirofumi Tsujino,Tadayuki Uno,Yasuo Tsutsumi,Yusuke Kawashima,Tatsuya Takagi,Kenichi Murai,Tomomi Nemoto,Mitsuhiro Arisawa, ACS Omega, Vol. 5, No. 5, p. 2473-2479, 2020/02/11
Direct synthesis of dialkylarylvinylsilane derivatives: metathesis of dialkylaryl-iso-propenylsilane and its application to tetracyclic silacycle dye synthesis, Shohei Yoshioka,Tsunayoshi Takehara,Tsuyoshi Matsuzaki,Takeyuki Suzuki,Hirofumi Tsujino,Tadayuki Uno,Yasuo Tsutsumi,Kenichi Murai,Hiromichi Fujioka,Mitsuhiro Arisawa, Chemical Communications, Royal Society of Chemistry (RSC), Vol. 55, No. 93, p. 14070-14073, 2019/11
ETS Proteins Bind with Glucocorticoid Receptors: Relevance for Treatment of Ewing Sarcoma, Swati Srivastava,Nishanth Belugali Nataraj,Arunachalam Sekar,Soma Ghosh,Chamutal Bornstein,Diana Drago-Garcia,Lee Roth,Donatella Romaniello,Ilaria Marrocco,Eyal David,Yuval Gilad,Mattia Lauriola,Ron Rotkopf,Adi Kimchi,Yuya Haga,Yasuo Tsutsumi,Olivier Mirabeau,Didier Surdez,Andrei Zinovyev,Olivier Delattre,Heinrich Kovar,Ido Amit,Yosef Yarden, Cell Reports, Elsevier BV, Vol. 29, No. 1, p. 104-117.e4, 2019/10
Ephrin type-A receptor 2 on tumor-derived exosomes enhances angiogenesis throuth the activation of MAPK signaling., Yamashita T,Kamada H,Kanasaki S,Nagano K,Inoue M,Higashisaka K,Yoshioka Y,Tsutsumi Y,Tsunoda S, Pharmazie., Vol. 74, No. 10, p. 614-619, 2019/10
Effect of Drug Combination on Omeprazole Metabolism by Cytochrome P450 2C19 in <i>Helicobacter pylori</i> Eradication Therapy, Tamer Z. Attia,Taku Yamashita,Hirofumi Tsujino,Sayed M. Derayea,Yasuo Tsutsumi,Tadayuki Uno, Chemical and Pharmaceutical Bulletin, Pharmaceutical Society of Japan, Vol. 67, No. 8, p. 810-815, 2019/08/01
Optimization and evaluation of pretreatment method for sp-ICP-MS to reveal the distribution of silver nanoparticles in the body., Ishizaka T,Nagano K,ual contributor,corresponding autour,Tasaki I,Tao H,Gao JQ,Harada K,Hirata K,Saito S,Tsujino H,Higashisaka K,Tsutsumi Y, Nanoscale Research Letters, Vol. 14, No. 1, p. 180-180, 2019/05
Autophagy is a new protective mechanism against the cytotoxicity of platinum nanoparticles in human trophoblasts., Nakashima A,Higashisaka K,Kusabiraki T,Aoki A,Ushijima A,Ono Y,Tsuda S,Shima T,Yoshino O,Nagano K,Yoshioka Y,Tsutsumi Y,Saito S, Scientific Reports, Vol. 9, No. 1, p. 5478-5478, 2019/04
心不全病態における細胞骨格系蛋白質の発現変動とその機能解明, 豊田麻人,東阪和馬,大須賀絵理,笠原淳平,櫻井美由紀,辻野博文,長野一也,藤尾慈,坂田泰史,堤康央, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 139年会, No. 4, p. 174-174, 2019/03
細胞接着関連蛋白質による近位尿細管の上皮間葉転換の抑制, 井阪亮,東阪和馬,竹谷苑子,石田菜南,坂橋優治,山口慎太郎,藤尾慈,神出計,辻野博文,長野一也,堤康央, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 139年会, No. 4, p. 63-63, 2019/03
糖尿病性腎症における免疫関連蛋白質の分泌機序の解明に向けた基礎情報の収集, 石田菜南,東阪和馬,竹谷苑子,井阪亮,坂橋優治,山口慎太郎,辻野博文,長野一也,藤尾慈,神出計,堤康央, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 139年会, No. 4, p. 174-174, 2019/03
エルロチニブ耐性化機構におけるPGRMC1の機能解析, 林穎,東阪和馬,新谷拓也,花室紗知代,泉沢航平,芳賀優弥,前田真一郎,辻野博文,長野一也,藤尾慈,堤康央, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 139年会, No. 4, p. 51-51, 2019/03
プロスタノイドの尿中最終代謝物同時定量法の最適化と応用, 張天斉,長野一也,黒田博隆,寺田壮志,原田和生,平田收正,辻野博文,東阪和馬,松本博志,堤康央, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 139年会, No. 3, p. 199-199, 2019/03
Eukaryotic translation initiation factor 3 subunit C is associated with acquired resistance to erlotinib in non-small cell lung cancer., Shintani T,Higashisaka K,Maeda M,Hamada M,Tsuji R,Kurihara K,Kashiwagi Y,Sato A,Obana M,Yamamoto A,Kawasaki K,Lin Y,Kijima T,Kinehara Y,Miwa Y,Maeda S,Morii E,Kumanogoh A,Tsutsumi Y,Nagatomo I,Fujio Y, Oncotarget, Vol. 9, No. 101, p. 37520-37533, 2018/12
Dasatinib shows different cytotoxicity in triple-negative breast cancer cell lines., Haga Yuya,Higashisaka Kazuma,Yang Lili,Sekine Naoki,Nagano Kazuya,Tsutsumi Yasuo, MOLECULAR CANCER RESEARCH, Vol. 16, No. 8, p. 27-28, 2018/08
Neutrophil depletion exacerbates pregnancy complications, including placental damage, induced by silica nanoparticles in mice., Higashisaka K,Nakashima A,Iwahara Y,Aoki A,Nakayama M,Yanagihara I,Lin Y,Nagano K,Tsunoda S,Saito S,Yoshioka Y,Tsutsumi Y, Frontiers in Immunology, Vol. 9, 2018/08
Development of a fundamental technology to seek drug targets and application for cancer targeting therapy., Kazuya Nagano,Kazuma Higashisaka,Shin-ichi Tsunoda,Yasuo Tsutsumi, YAKUGAKU ZASSHI, Pharmaceutical Society of Japan, Vol. 138, No. 7, p. 903-909, 2018/07
分子進化技術によるサイトカイン機能改変体の創製とDDSへの展開, 長野一也,東阪和馬,堤康央, ドラッグデリバリーシステム, 2018/06
慢性腎臓病に対する診断バイオマーカーの確立に向けた腎分泌蛋白質の有用性評価, 石田菜南,東阪和馬,竹谷苑子,井阪亮,尾花理徳,鎌田春彦,前田真貴子,長野一也,藤尾慈,神出計,堤康央, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 138年会, No. 4, p. 188-188, 2018/03
近位尿細管細胞の上皮間葉転換に対する細胞接着関連蛋白質の寄与解明に向けた検討, 井阪亮,東阪和馬,竹谷苑子,石田奈南,藤尾慈,神出計,長野一也,堤康央, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 138年会, No. 3, p. 63-63, 2018/03
プロスタノイドの尿中最終代謝物同時定量法の確立とその評価, 張天斉,長野一也,黒田博隆,原田和生,平田收正,東阪和馬,松本博志,堤康央, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 138年会, No. 3, p. 235-235, 2018/03
ナノ化学物質の安全性評価と展望食品関連製品に含まれるナノ素材の安全性評価ナノ安全科学研究からナノ最適デザイン研究へ, 東阪和馬,長野一也,松本博志,堤康央, 日本毒性病理学会講演要旨集, 日本毒性病理学会, Vol. 34回, p. 49-49, 2018/01
Nano-Safety Science Research Based on Pharmaceutical Science and Technology, Nagano Kazuya,Higashisaka Kazuma,Tsutsumi Yasuo, Journal of Pharmaceutical Science and Technology, Japan, The Academy of Pharmaceutical Science and Technology, Japan, Vol. 77, No. 6, p. 287-291, 2017/11
DOHaD仮説に基づいたナノマテリアルの生殖発生毒性, 東阪和馬,長野一也,堤康央, 2017/09
Intracellular trafficking of particles inside endosomal vesicles is regulated by particle size, Michihiko Aoyama,Yasuo Yoshioka,Yoshiyuki Arai,Haruna Hirai,Rio Ishimoto,Kazuya Nagano,Kazuma Higashisaka,Takeharu Nagai,Yasuo Tsutsumi, JOURNAL OF CONTROLLED RELEASE, ELSEVIER SCIENCE BV, Vol. 260, p. 183-193, 2017/08
Safety evaluation for nanoparticles in cosmetics by using skin cell lines, Vol. 45, No. 7, p. 55-60, 2017/07
Permeability of skin to silver nanoparticles after epidermal skin barrier disruption in rats, Kuwagata Makiko,Kumagai Fumiaki,Saito Yoshiaki,Higashisaka Kazuma,Yoshioka Yasuo,Tsutsumi Yasuo, Fundamental Toxicological Sciences, The Japanese Society of Toxicology, Vol. 4, No. 3, p. 109-119, 2017/06
Human scavenger receptor A1-mediated inflammatory response to silica particle exposure is size specific, Nobuo Nishijima,Toshiro Hirai,Kazuki Misato,Michihiko Aoyama,Etsushi Kuroda,Ken J. Ishii,Kazuma Higashisaka,Yasuo Yoshioka,Yasuo Tsutsumi, Frontiers in Immunology, Frontiers Research Foundation, Vol. 8, No. APR, 2017/04/03
Reduction of calcium flux from the extracellular region and endoplasmic reticulum by amorphous nano-silica particles owing to carboxy group addition on their surface, Akira Onodera,Katsutoshi Yayama,Hideto Morosawa,Yukina Ishii,Yasuo Tsutsumi,Yuichi Kawai, Biochemistry and Biophysics Reports, Elsevier B.V., Vol. 9, p. 330-334, 2017/03/01
Moesin is activated in cardiomyocytes in experimental autoimmune myocarditis and mediates tissue restoration with protrusion formation, Mitsuhara Yusuke,Miyawaki Akimitsu,Orimoto Aya,Nakayasu Yusuke,Tsunoda Shin-ichi,Obana Masanori,Maeda Makiko,Nakayama Hiroyuki,Yoshioka Yasuo,Tsutsumi Yasuo,Fujio Yasushi, JOURNAL OF PHARMACOLOGICAL SCIENCES, Vol. 133, No. 3, 2017/03
Nano-safety Research: Examining the Associations among the Biological Effects of Nanoparticles and Their Physicochemical Properties and Kinetics, Kazuma Higashisaka,Kazuya Nagano,Yasuo Yoshioka,Yasuo Tsutsumi, BIOLOGICAL & PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOC JAPAN, Vol. 40, No. 3, p. 243-248, 2017/03
Cellular internalization, transcellular transport, and cellular effects of silver nanoparticles in polarized Caco-2 cells following apical or basolateral exposure, Shunji Imai,Yuki Morishita,Tomoyuki Hata,Masuo Kondoh,Kiyohito Yagi,Jian-Qing Gao,Kazuya Nagano,Kazuma Higashisaka,Yasuo Yoshioka,Yasuo Tsutsumi, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC ELSEVIER SCIENCE, Vol. 484, No. 3, p. 543-549, 2017/03
Identifying a size-specific hazard of silica nanoparticles after intravenous administration and its relationship to the other hazards that have negative correlations with the particle size in mice, Takayuki Handa,Toshiro Hirai,Natsumi Izumi,Shun-ichi Eto,Shin-ichi Tsunoda,Kazuya Nagano,Kazuma Higashisaka,Yasuo Yoshioka,Yasuo Tsutsumi, NANOTECHNOLOGY, IOP PUBLISHING LTD, Vol. 28, No. 13, 2017/02
Allergic Responses induced by the immunomodulatory effects of Nanomaterials upon Skin exposure, Yasuo Yoshioka,Etsushi Kuroda,Toshiro Hirai,Yasuo Tsutsumi,Ken J. Ishii, FRONTIERS IN IMMUNOLOGY, FRONTIERS MEDIA SA, Vol. 8, 2017/02
A trimeric structural fusion of an antagonistic tumor necrosis factor-α mutant enhances molecular stability and enables facile modification, Masaki Inoue,Daisuke Ando,Haruhiko Kamada,Shintaro Taki,Mayumi Niiyama,Yohei Mukai,Takashi Tadokoro,Katsumi Maenaka,Taisuke Nakayama,Yuji Kado,Tsuyoshi Inoue,Yasuo Tsutsumi,Shin-ichi Tsunoda, Journal of Biological Chemistry, 2017/02
A trimeric structural fusion of an antagonistic tumor necrosis factor-α mutant enhances molecular stability and enables facile modification, Inoue M,Ando D,Kamada H,Taki S,Niiyama M,Mukai Y,Tadokoro T,Maenaka K,Nakayama T,Kado Y,Inoue T,Tsutsumi Y,Tsunoda S, J. Biol. Chem., 2017/02
Modifying the surface of silica nanoparticles with amino or carboxyl groups decreases their cytotoxicity to parenchymal hepatocytes., Nagano T,Nagano K,Nabeshi H,Yoshida T,Kamada H,Tsunoda S,Gao JQ,Higashisaka K,Yoshioka Y,Tsutsumi Y, Biological & Pharmaceutical Bulletin, The Pharmaceutical Society of Japan, Vol. 40(5), No. 5, p. 726-728, 2017/02
Hepatotoxicity, nephrotoxicity, and drug/chemical interaction toxicity of platinum nanoparticles in mice, K. Isoda,T. Daibo,K. Yushina,Y. Yoshioka,Y. Tsutsumi,Y. Akimoto,H. Kawakami,Y. Taira,I. Taira,R. Yanoshita,T. Nishimura,I. Ishida, PHARMAZIE, GOVI-VERLAG PHARMAZEUTISCHER VERLAG GMBH, Vol. 72, No. 1, p. 10-16, 2017/01
Chitosan nanoparticles and their Tween 80 modified counterparts disrupt the developmental profile of zebrafish embryos, Zhongyue Yuan,Ying Li,Yulan Hu,Jian You,Kazuma Higashisaka,Kazuya Nagano,Yasuo Tsutsumi,Jianqing Gao, INTERNATIONAL JOURNAL OF PHARMACEUTICS, ELSEVIER SCIENCE BV, Vol. 515, No. 1-2, p. 644-656, 2016/12
Clusterin in the protein corona plays a key role in the stealth effect of nanoparticles against phagocytes, Michihiko Aoyama,Katutomo Hata,Kazuma Higashisaka,Kazuya Nagano,Yasuo Yoshioka,Yasuo Tsutsumi, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC ELSEVIER SCIENCE, Vol. 480, No. 4, p. 690-695, 2016/11
Amorphous nanosilica particles evoke vascular relaxation through PI3K/Akt/eNOS signaling, Akira Onodera,Katsutoshi Yayama,Atsushi Tanaka,Hideto Morosawa,Takuya Furuta,Naoya Takeda,Kisa Kakiguchi,Shigenobu Yonemura,Itaru Yanagihara,Yasuo Tsutsumi,Yuichi Kawai, Fundamental and Clinical Pharmacology, Blackwell Publishing Ltd, Vol. 30, No. 5, p. 419-428, 2016/10/01
Potential Suppressive Effects of Two C-60 Fullerene Derivatives on Acquired Immunity, Toshiro Hirai,Yasuo Yoshioka,Asako Udaka,Eiichiro Uemura,Tomoyuki Ohe,Hisae Aoshima,Jian-Qing Gao,Ken Kokubo,Takumi Oshima,Kazuya Nagano,Kazuma Higashisaka,Tadahiko Mashino,Yasuo Tsutsumi, NANOSCALE RESEARCH LETTERS, SPRINGER, Vol. 11, No. 1, 2016/10
ナノ粒子の安全科学研究, 東阪和馬,吉岡靖雄,堤康央, 2016/10
Creation of mouse TNFR2-selective agonistic TNF mutants using a phage display technique, Daisuke Ando,Masaki Inoue,Haruhiko Kamada,Shintaro Taki,Takeshi Furuya,Yasuhiro Abe,Kazuya Nagano,Yasuo Tsutsumi,Shin-ichi Tsunoda, Biochemistry and Biophysics Reports, Elsevier B.V., Vol. 7, p. 309-315, 2016/09/01
Distribution of Silver Nanoparticles to Breast Milk and Their Biological Effects on Breast-Fed Offspring Mice, Yuki Morishita,Yasuo Yoshioka,Yuya Takimura,Yuki Shimizu,Yuki Namba,Nao Nojiri,Takuya Ishizaka,Keizo Takao,Fumiyoshi Yamashita,Kazuhiro Takuma,Yukio Ago,Kazuya Nagano,Yohei Mukai,Haruhiko Kamada,Shin-ichi Tsunoda,Shigeru Saito,Toshio Matsuda,Mitsuru Hashida,Tsuyoshi Miyakawa,Kazuma Higashisaka,Yasuo Tsutsumi, ACS NANO, AMER CHEMICAL SOC, Vol. 10, No. 9, p. 8180-8191, 2016/09
Metal nanoparticles in the presence of lipopolysaccharides trigger the onset of metal allergy in mice, Toshiro Hirai,Yasuo Yoshioka,Natsumi Izumi,Ko-ichi Ichihashi,Takayuki Handa,Nobuo Nishijima,Eiichiro Uemura,Ko-ichi Sagami,Hideki Takahashi,Manami Yamaguchi,Kazuya Nagano,Yohei Mukai,Haruhiko Kamada,Shin-ichi Tsunoda,Ken J. Ishii,Kazuma Higashisaka,Yasuo Tsutsumi, NATURE NANOTECHNOLOGY, NATURE PUBLISHING GROUP, Vol. 11, No. 9, p. 808-816, 2016/09
Moesin is activated in cardiomyocytes in experimental autoimmune myocarditis and mediates cytoskeletal reorganization with protrusion formation, Akimitsu Miyawaki,Yusuke Mitsuhara,Aya Orimoto,Yusuke Nakayasu,Shin-ichi Tsunoda,Masanori Obana,Makiko Maeda,Hiroyuki Nakayama,Yasuo Yoshioka,Yasuo Tsutsumi,Yasushi Fujio, AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, AMER PHYSIOLOGICAL SOC, Vol. 311, No. 2, p. H476-H486, 2016/08
High-dose cutaneous exposure to mite allergen induces IgG-mediated protection against anaphylaxis, T. Hirai,Y. Yoshioka,H. Takahashi,T. Handa,N. Izumi,T. Mori,E. Uemura,N. Nishijima,K. Sagami,M. Yamaguchi,S. Eto,K. Nagano,H. Kamada,S. Tsunoda,K. J. Ishii,K. Higashisaka,Y. Tsutsumi, CLINICAL AND EXPERIMENTAL ALLERGY, WILEY-BLACKWELL, Vol. 46, No. 7, p. 992-1003, 2016/07
Relationship between size and surface modification of silica particles and enhancement and suppression of inflammatory cytokine production by lipopolysaccharide- or peptidoglycan-stimulated RAW264.7 macrophages, Eiichiro Uemura,Yasuo Yoshioka,Toshiro Hirai,Takayuki Handa,Kazuya Nagano,Kazuma Higashisaka,Yasuo Tsutsumi, JOURNAL OF NANOPARTICLE RESEARCH, SPRINGER, Vol. 18, No. 6, 2016/06
Development of novel drug delivery systems using phage display technology for clinical application of protein drugs, Kazuya Nagano,Yasuo Tsutsumi, PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES, JAPAN ACAD, Vol. 92, No. 5, p. 156-166, 2016/05
Generation of a sensitive TNFR2-specific murine assays system, D. Ando,H. Kamada,M. Inoue,S. Taki,T. Furuya,Y. Abe,K. Nagano,Y. Tsutsumi,S. Tsunoda, PHARMAZIE, GOVI-VERLAG PHARMAZEUTISCHER VERLAG GMBH, Vol. 71, No. 5, p. 235-237, 2016/05
Effect of nanomaterials on permeability of placental barrier focused on intercellular space, SHIMIZU Yuki,HIGASHISAKA Kazuma,AOYAMA Michihiko,NAMBA Yuki,IZUMI Masahiro,NAGANO Kazuya,YOSHIOKA Yasuo,TSUTSUMI Yasuo, Annual Meeting of the Japanese Society of Toxicology, The Japanese Society of Toxicology, Vol. 43, p. O-37, 2016
The effects of silver nanoparticles on DNA methyltransferase, MAKI Ayaka,HIGASHISAKA Kazuma,AOYAMA Michihiko,NISHIKAWA Yuki,ISHIZAKA Takuya,KASAHARA Junpei,NAGANO Kazuya,YOSHIOKA Yasuo,TSUTSUMI Yasuo, Annual Meeting of the Japanese Society of Toxicology, The Japanese Society of Toxicology, Vol. 43, p. O-35, 2016
The analysis of the pathogenesis of metal allergy in the animal model mediated by nanoparticles focused on the adjuvant, IZUMI Natsumi,YOSHIOKA Yasuo,HIRAI Toshiro,HANDA Takayuki,ETO Syun-ichi,AOYAMA Michihiko,NAGANO Kazuya,HIGASHISAKA Kazuma,TSUTSUMI Yasuo, Annual Meeting of the Japanese Society of Toxicology, The Japanese Society of Toxicology, Vol. 43, p. O-36, 2016
The effect of autophagy inhibition on uptake of nanomaterials, AOYAMA Michihiko,ISHIMOTO Rio,HIRAI Haruna,NAGANO Kazuya,SAITO Shigeru,HIGASHISAKA Kazuma,YOSHIOKA Yasuo,TSUTSUMI Yasuo, Annual Meeting of the Japanese Society of Toxicology, The Japanese Society of Toxicology, Vol. 43, p. P-9, 2016
The basic analysis on intracellular movement of nanoparticles, HIRAI Haruna,HIGASHISAKA Kazuma,AOYAMA Michihiko,ARAI Yoshiyuki,ISHIMOTO Rio,NAGANO Kazuya,NAGAI Takeharu,YOSHIOKA Yasuo,TSUTSUMI Yasuo, Annual Meeting of the Japanese Society of Toxicology, The Japanese Society of Toxicology, Vol. 43, p. P-212, 2016
The establishment of single particle ICP-MS to determine the metal nanoparticles, ISHIZAKA Takuya,HIGASHISAKA Kazuma,AOYAMA Michihiko,NISHIKAWA Yuki,MAKI Ayaka,KASAHARA Junpei,NAGANO Kazuya,YOSHIOKA Yasuo,TSUTSUMI Yasuo, Annual Meeting of the Japanese Society of Toxicology, The Japanese Society of Toxicology, Vol. 43, p. P-11, 2016
Biocompatibility of nanomaterials, Yoshioka Y,Higashisaka K,Tsutsumi Y, Nanomaterials in Pharmacology, 2016/01
Furospinosulin-1, Marine Spongean Furanosesterterpene, Suppresses the Growth of Hypoxia-Adapted Cancer Cells by Binding to Transcriptional Regulators p54(nrb) and LEDGF/p75, Masayoshi Arai,Takashi Kawachi,Naoyuki Kotoku,Chiaki Nakata,Haruhiko Kamada,Shin-ichi Tsunoda,Yasuo Tsutsumi,Hiroko Endo,Masahiro Inoue,Hiroki Sato,Motomasa Kobayashi, CHEMBIOCHEM, WILEY-V C H VERLAG GMBH, Vol. 17, No. 2, p. 181-189, 2016/01
A Novel Bispecific Antibody against Human CD3 and Ephrin Receptor A10 for Breast Cancer Therapy, Shintaro Taki,Haruhiko Kamada,Masaki Inoue,Kazuya Nagano,Yohei Mukai,Kazuma Higashisaka,Yasuo Yoshioka,Yasuo Tsutsumi,Shin-ichi Tsunoda, PLOS ONE, PUBLIC LIBRARY SCIENCE, Vol. 10, No. 12, 2015/12
Hydroxylated fullerene: a potential antiinflammatory and antioxidant agent for preventing mouse preterm birth, Tetsu Wakimoto,Kaoru Uchida,Kazuya Mimura,Takeshi Kanagawa,Tzvetozar Roussev Mehandjiev,Hisae Aoshima,Ken Kokubo,Nobuaki Mitsuda,Yasuo Yoshioka,Yasuo Tsutsumi,Tadashi Kimura,Itaru Yanagihara, AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, MOSBY-ELSEVIER, Vol. 213, No. 5, 2015/11
Reproductive and developmental effects of nanomaterials, Yuki Morishita,Yasuo Yoshioka,Kazuma Higashisaka,Yasuo Tsutsumi, Biological Effects of Fibrous and Particulate Substances, Springer Japan, p. 77-101, 2015/10/26
Potential hazards of skin exposure to nanoparticles, Toshiro Hirai,Yasuo Yoshioka,Kazuma Higashisaka,Yasuo Tsutsumi, Biological Effects of Fibrous and Particulate Substances, Springer Japan, p. 123-135, 2015/10/26
Structural basis for signal initiation by TNF and TNFR, Teruya Nakamura,Yohei Mukai,Yasuo Tsutsumi,Yuriko Yamagata, Protein Modifications in Pathogenic Dysregulation of Signaling, Springer Japan, p. 127-141, 2015/09/02
Biodistribution and therapeutic effects of a monoclonal antibody against Eph receptor A10 in a breast cancer xenograft model, Nagano Kazuya,Maeda Yuka,Yamashita Takuya,Mukai Yohei,Kamada Haruhiko,Higashisaka Kazuma,Yoshioka Yasuo,Tsutsumi Yasuo,Tsunoda Shin-ichi, CANCER RESEARCH, Vol. 75, 2015/08/01
脆弱な個体をも対象としたナノ安全科学研究～Sustainable Nanotechnologyを目指して～, 吉岡靖雄,東阪和馬,堤康央, 2015/07
金属系ナノマテリアルのナノ安全科学研究～Sustainable Nanotechnologyを目指して～, 吉岡靖雄,東阪和馬,堤康央, 2015/07
Identification and evaluation of metastasis-related proteins, oxysterol binding protein-like 5 and calumenin, in lung tumors, Kazuya Nagano,Sunao Imai,Xiluli Zhao,Takuya Yamashita,Yasuo Yoshioka,Yasuhiro Abe,Yohei Mukai,Haruhiko Kamada,Shinsaku Nakagawa,Yasuo Tsutsumi,Shin-Ichi Tsunoda, INTERNATIONAL JOURNAL OF ONCOLOGY, SPANDIDOS PUBL LTD, Vol. 47, No. 1, p. 195-203, 2015/07
Understanding of immunotoxicity of engineered nanomaterials for the sustainable nanotechnology, Yoshioka Y,Tsutsumi Y, 2015/06
Sustainable Nanotechnologyを目指したナノ安全科学研究, 吉岡靖雄,東阪和馬,堤康央, 2015/06
Applications and Safety of Nanomaterials Used in the Food Industry, Higashisaka Kazuma,Yoshioka Yasuo,Tsutsumi Yasuo, Food Safety, Food Safety Commission, Cabinet Office, Government of Japan, Vol. 3, No. 2, p. 39-47, 2015/06
Cutaneous exposure to agglomerates of silica nanoparticles and allergen results in IgE-biased immune response and increased sensitivity to anaphylaxis in mice, Toshiro Hirai,Yasuo Yoshioka,Hideki Takahashi,Ko-ichi Ichihashi,Asako Udaka,Takahide Mori,Nobuo Nishijima,Tokuyuki Yoshida,Kazuya Nagano,Haruhiko Kamada,Shin-ichi Tsunoda,Tatsuya Takagi,Ken J. Ishii,Hiromi Nabeshi,Tomoaki Yoshikawa,Kazuma Higashisaka,Yasuo Tsutsumi, PARTICLE AND FIBRE TOXICOLOGY, BIOMED CENTRAL LTD, Vol. 12, No. 1, 2015/06
Protein corona changes mediated by surface modification of amorphous silica nanoparticles suppress acute toxicity and activation of intrinsic coagulation cascade in mice, Tokuyuki Yoshida,Yasuo Yoshioka,Yuki Morishita,Michihiko Aoyama,Saeko Tochigi,Toshiro Hirai,Kota Tanaka,Kazuya Nagano,Haruhiko Kamada,Shin-ichi Tsunoda,Hiromi Nabeshi,Tomoaki Yoshikawa,Kazuma Higashisaka,Yasuo Tsutsumi, NANOTECHNOLOGY, IOP PUBLISHING LTD, Vol. 26, No. 24, 2015/06
Applications and Safety of Nanomaterials Used in the Food Industry, Higashisaka Kazuma,Yoshioka Yasuo,Tsutsumi Yasuo, Food Safety, Food Safety Commission, Cabinet Office, Government of Japan, Vol. 3, No. 2, p. 39-47, 2015/06
Protein corona changes mediated by surface modification of amorphous silica nanoparticles suppress acute toxicity and activation of intrinsic coagulation cascade in mice, Tokuyuki Yoshida,Yasuo Yoshioka,Yuki Morishita,Michihiko Aoyama,Saeko Tochigi,Toshiro Hirai,Kota Tanaka,Kazuya Nagano,Haruhiko Kamada,Shin-ichi Tsunoda,Hiromi Nabeshi,Tomoaki Yoshikawa,Kazuma Higashisaka,Yasuo Tsutsumi, NANOTECHNOLOGY, IOP PUBLISHING LTD, Vol. 26, No. 24, 2015/06
ナノ粒子曝露に着眼したアレルギー発症要因の理解に向けて, 吉岡靖雄,堤康央, 2015/05
「安全と安心」を強みにした、付加価値の高い香粧品への期待, 堤康央, 2015/04
ナノマテリアルの安全性評価（最終回）, 堤康央, MEDCHEM NEWS, 2015/03
ナノマテリアルの安全性評価（2）, 堤康央, MEDCHEM NEWS, 2015/02
Aminopeptidase P3, a new member of the TNF-TNFR2 signaling complex, induces phosphorylation of JNK1 and JNK2, Masaki Inoue,Haruhiko Kamada,Yasuhiro Abe,Kazuma Higashisaka,Kazuya Nagano,Yohei Mukai,Yasuo Yoshioka,Yasuo Tsutsumi,Shin-ichi Tsunoda, JOURNAL OF CELL SCIENCE, COMPANY OF BIOLOGISTS LTD, Vol. 128, No. 4, p. 656-669, 2015/02
Effects of nanoparticles on DNA methylation on alveolar epithelial cells, MAKI Ayaka,HIGASHISAKA Kazuma,NISHIKAWA Yuki,YOSHIOKA Yasuo,TSUTSUMI Yasuo, Annual Meeting of the Japanese Society of Toxicology, The Japanese Society of Toxicology, Vol. 42, p. P-94, 2015
The identification of a cell type that concerned about the pathogenesis of metal allergy in animal model mediated by metal nanoparticles, IZUMI Natsumi,YOSHIOKA Yasuo,HIRAI Toshiro,NISHIJIMA Nobuo,HANDA Takayuki,HIGASHISAKA Kazuma,TSUTSUMI Yasuo, Annual Meeting of the Japanese Society of Toxicology, The Japanese Society of Toxicology, Vol. 42, p. P-93, 2015
A study on the elucidation of the chronic exposure to nanoparticles –the evaluation of proinflammatory activities induced by daily exposure to silver nanoparticles-, NISHIKAWA Yuki,HIGASHISAKA Kazuma,MAKI Ayaka,YOSHIOKA Yasuo,TSUTSUMI Yasuo, Annual Meeting of the Japanese Society of Toxicology, The Japanese Society of Toxicology, Vol. 42, p. O-2, 2015
Transgenerational effects of nanomaterials through paternal exposure, NAMBA Yuki,YOSHIOKA Yasuo,MORISHITA Yuki,TAKIMURA Yuya,SHIMIZU Yuki,AGO Yukio,TAKUMA Kazuhiro,MATSUDA Toshio,HIGASHISAKA Kazuma,TSUTSUMI Yasuo, Annual Meeting of the Japanese Society of Toxicology, The Japanese Society of Toxicology, Vol. 42, p. O-1, 2015
The mechanism analysis of silica nanoparticles-induced acute toxicity focused on platelet, HANDA Takayuki,YOSHIOKA Yasuo,HIRAI Toshiro,NISHIJIMA Nobuo,IZUMI Natsumi,HIGASHISAKA Kazuma,TSUTSUMI Yasuo, Annual Meeting of the Japanese Society of Toxicology, The Japanese Society of Toxicology, Vol. 42, p. P-92, 2015
Effect of nanomaterial on permeability of blood-placenta barrier, SHIMIZU Yuki,YOSHIOKA Yasuo,MORISHITA Yuki,TAKIMURA Yuya,NAMBA Yuki,YANAGIHARA Itaru,HIGASHISAKA Kazuma,TSUTSUMI Yasuo, Annual Meeting of the Japanese Society of Toxicology, The Japanese Society of Toxicology, Vol. 42, p. P-88, 2015
Short-term changes in intracellular ROS localisation after the silver nanoparticles exposure depending on particle size., Onodera A,Nishiumi F,Kakiguchi K,Tanaka A,Tanabe N,Honma A,Yayama K,Yoshioka Y,Nakahira K,Yonemura S,Yanagihara I,Tsutsumi Y,Kawai Y, Toxicol Rep., Vol. Mar 23;2:574-579., 2015
Silica nanoparticle-induced toxicity in mouse lung and liver imaged by electron microscopy, Isoda Katsuhiro,Kondoh Masuo,Yoshioka Yasuo,Tsutsumi Yasuo,Imazawa Takayoshi,Nishimura Tetsuji,Ishida Isao,Yagi Kiyohito, Fundamental Toxicological Sciences, The Japanese Society of Toxicology, Vol. 2, No. 1, p. 19-23, 2015/01
Generation and characterization of a bispecific diabody targeting both EPH receptor A10 and CD3, Haruhiko Kamada,Shintaro Taki,Kazuya Nagano,Masaki Inoue,Daisuke Ando,Yohei Mukai,Kazuma Higashisaka,Yasuo Yoshioka,Yasuo Tsutsumi,Shin-ichi Tsunoda, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC ELSEVIER SCIENCE, Vol. 456, No. 4, p. 908-912, 2015/01
ナノマテリアルの安全性評価（１）, 堤康央, MEDCHEM NEWS, 2015/01
Sustainable nanotechnology, Christopher J. Rhodes, SCIENCE PROGRESS, SCIENCE REVIEWS 2000 LTD, Vol. 98, No. 1, p. 63-72, 2015
Evaluation of silica nanoparticle binding to major human blood proteins, Katsutomo Hata,Kazuma Higashisaka,Kazuya Nagano,Yohei Mukai,Haruhiko Kamada,Shin-ichi Tsunoda,Yasuo Yoshioka,Yasuo Tsutsumi, NANOSCALE RESEARCH LETTERS, SPRINGER, Vol. 9, 2014/12
Size and surface modification of amorphous silica particles determine their effects on the activity of human CYP3A4 in vitro, Shunji Imai,Yasuo Yoshioka,Yuki Morishita,Tokuyuki Yoshida,Miyuki Uji,Kazuya Nagano,Yohei Mukai,Haruhiko Kamada,Shin-ichi Tsunoda,Kazuma Higashisaka,Yasuo Tsutsumi, NANOSCALE RESEARCH LETTERS, SPRINGER, Vol. 9, 2014/12
プロテオミクス技術を用いたバイオマーカーの開発, 鎌田春彦,角田慎一,堤康央, 医学の歩み, 2014/10
Neutrophilia due to silica nanoparticles induces release of double-stranded DNA., Higashisaka K,Kunieda A,Iwahara Y,Tanaka K,Nagano K,Mukai Y,Kamada H,Tsunoda S,Yoshioka Y,Tsutsumi Y, Journal of Nanomedicine & Nanotechnology., 2014/10
The absorption, distribution, metabolism, and excretion profile of nanoparticles., Yoshioka Y,Higashisaka K,Tsunoda S,Tsutsumi Y, Engineered Cell Manipulation for Biomedical Application., 2014/09
Intestinal absorption and biological effects of orally administered amorphous silica particles, Tokuyuki Yoshida,Yasuo Yoshioka,Hideki Takahashi,Kazuki Misato,Takahide Mori,Toshiro Hirai,Kazuya Nagano,Yasuhiro Abe,Yohei Mukai,Haruhiko Kamada,Shin-ichi Tsunoda,Hiromi Nabeshi,Tomoaki Yoshikawa,Kazuma Higashisaka,Yasuo Tsutsumi, NANOSCALE RESEARCH LETTERS, SPRINGER, Vol. 9, 2014/09
Ephrin receptor A10 is a promising drug target potentially useful for breast cancers including triple negative breast cancers, Kazuya Nagano,Yuka Maeda,So-ichiro Kanasaki,Takanobu Watanabe,Takuya Yamashita,Masaki Inoue,Kazuma Higashisaka,Yasuo Yoshioka,Yasuhiro Abe,Yohei Mukai,Haruhiko Kamada,Yasuo Tsutsumi,Shin-ichi Tsunoda, JOURNAL OF CONTROLLED RELEASE, ELSEVIER SCIENCE BV, Vol. 189, p. 72-79, 2014/09
Eph receptor A10 has a potential as a target for a prostate cancer therapy, Kazuya Nagano,Takuya Yamashita,Masaki Inoue,Kazuma Higashisaka,Yasuo Yoshioka,Yasuhiro Abe,Yohei Mukai,Haruhiko Kamada,Yasuo Tsutsumi,Shin-ichi Tsunoda, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC ELSEVIER SCIENCE, Vol. 450, No. 1, p. 545-549, 2014/07
Nano-safety Science for Sustainable Nanotechnology, Yasuo Yoshioka,Yasuo Tsutsumi, YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, PHARMACEUTICAL SOC JAPAN, Vol. 134, No. 6, p. 737-742, 2014/06
Recent Topics on Development of Nanomaterials and Nano-Safety Science Foreword, Yasuo Yoshioka,Yasuo Tsutsumi, YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, PHARMACEUTICAL SOC JAPAN, Vol. 134, No. 6, p. 721-722, 2014/06
経皮曝露に着目したナノマテリアルの安全性評価, 東阪和馬,吉岡靖雄,堤康央, ファームテックジャパン, 2014/05
The effects of silica nanoparticles on allergic diseases : For the development of nanomaterials with efficacy and safety, Vol. 61, No. 4, p. 352-356, 2014/04
Proteomics approach for searching diagnostic markers of Parkinson's disease., MISATO Kazuki,MUKAI Yohei,HIGASHISAKA Kazuma,YOSHIOKA Yasuo,NAGANO Kazuya,KAMADA Haruhiko,FUJIO Yasushi,MOCHIZUKI Hideki,TSUNODA Shin-ichi,TSUTSUMI Yasuo, Abstracts for Annual Meeting of Japanese Proteomics Society, Japanese Proteomics Society (Japan Human Proteome Organisation), Vol. 2014, p. 73-73, 2014
Asian Dust Particles Induce Macrophage Inflammatory Responses via Mitogen-Activated Protein Kinase Activation and Reactive Oxygen Species Production, Kazuma Higashisaka,Maho Fujimura,Mayu Taira,Tokuyuki Yoshida,Shin-ichi Tsunoda,Takashi Baba,Nobuyasu Yamaguchi,Hiromi Nabeshi,Tomoaki Yoshikawa,Masao Nasu,Yasuo Yoshioka,Yasuo Tsutsumi, JOURNAL OF IMMUNOLOGY RESEARCH, HINDAWI PUBLISHING CORPORATION, 2014
Expression of Eph receptor A10 is correlated with lymph node metastasis and stage progression in breast cancer patients, Kazuya Nagano,So-ichiro Kanasaki,Takuya Yamashita,Yuka Maeda,Masaki Inoue,Kazuma Higashisaka,Yasuo Yoshioka,Yasuhiro Abe,Yohei Mukai,Haruhiko Kamada,Yasuo Tsutsumi,Shin-ichi Tsunoda, CANCER MEDICINE, WILEY-BLACKWELL, Vol. 2, No. 6, p. 972-977, 2013/12
Epidermal growth factor receptor localized to exosome membranes as a possible biomarker for lung cancer diagnosis, T. Yamashita,H. Kamada,S. Kanasaki,Y. Maeda,K. Nagano,Y. Abe,M. Inoue,Y. Yoshioka,Y. Tsutsumi,S. Katayama,M. Inoue,Shin-Ichi Tsunoda, Pharmazie, Vol. 68, No. 12, p. 969-973, 2013/12
Proteome profiling and detecting method of lung cancer cell-derived exosomes as tumor biomarkers., Kamada Haruhiko,Yamashita Takuya,Inoue Masaki,Nagano Kazuya,Katayama Sumie,Mukai Yohei,Yoshioka Yasuo,Higashisaka Kazuma,Tsutsumi Yasuo,Tsunoda Shin-ichi, MOLECULAR CANCER THERAPEUTICS, Vol. 12, No. 11, 2013/11
Anti-EphA10 monoclonal antibody is a potential therapy against EphA10 positive breast cancer., Nagano Kazuya,Maeda Yuka,Yamashita Takuya,Inoue Masaki,Abe Yasuhiro,Mukai Yohei,Kamada Haruhiko,Higashisaka Kazuma,Yoshioka Yasuo,Tsutsumi Yasuo,Tsunoda Shin-ichi, MOLECULAR CANCER THERAPEUTICS, Vol. 12, No. 11, 2013/11
Liver-specific microRNAs as biomarkers of nanomaterial-induced liver damage, Takashi Nagano,Kazuma Higashisaka,Akiyoshi Kunieda,Yuki Iwahara,Kota Tanaka,Kazuya Nagano,Yasuhiro Abe,Haruhiko Kamada,Shin-ichi Tsunoda,Hiromi Nabeshi,Tomoaki Yoshikawa,Yasuo Yoshioka,Yasuo Tsutsumi, NANOTECHNOLOGY, IOP PUBLISHING LTD, Vol. 24, No. 40, 2013/10
Acute and chronic nephrotoxicity of platinum nanoparticles in mice, Yoshiaki Yamagishi,Akihiro Watari,Yuya Hayata,Xiangru Li,Masuo Kondoh,Yasuo Yoshioka,Yasuo Tsutsumi,Kiyohito Yagi, NANOSCALE RESEARCH LETTERS, SPRINGER, Vol. 8, 2013/09
経皮吸収性に着目したナノマテリアルの安全性評価研究, 東阪和馬,吉岡靖雄,堤康央, コスメテックジャパン, 2013/08
Intranasal exposure to amorphous nanosilica particles could activate intrinsic coagulation cascade and platelets in mice, Tokuyuki Yoshida,Yasuo Yoshioka,Saeko Tochigi,Toshiro Hirai,Miyuki Uji,Ko-ichi Ichihashi,Kazuya Nagano,Yasuhiro Abe,Haruhiko Kamada,Shin-ichi Tsunoda,Hiromi Nabeshi,Kazuma Higashisaka,Tomoaki Yoshikawa,Yasuo Tsutsumi, PARTICLE AND FIBRE TOXICOLOGY, BIOMED CENTRAL LTD, Vol. 10, 2013/08
Suppression of alkylating agent induced cell transformation and gastric ulceration by low-dose alkylating agent pretreatment, Akira Onodera,Yuichi Kawai,Asako Kashimura,Fumiya Ogita,Yasuo Tsutsumi,Norio Itoh, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC ELSEVIER SCIENCE, Vol. 435, No. 4, p. 714-719, 2013/06
薬学の未来にむけて：アカデミア創薬への挑戦（巻頭言）, 堤康央, 生産と技術, 2013/04
Pharmaceutical Science for Innovative Drugs with Safety and Reassurance, TSUTSUMI Yasuo, Vol. 73, No. 2, p. 83-83, 2013/03
Hepatotoxicity of sub-nanosized platinum particles in mice, Y. Yamagishi,A. Watari,Y. Hayata,X. Li,M. Kondoh,Y. Tsutsumi,K. Yagi, PHARMAZIE, GOVI-VERLAG PHARMAZEUTISCHER VERLAG GMBH, Vol. 68, No. 3, p. 178-182, 2013/03
Recent Topics about Nano-safety Science and Its Future, Yasuo Yoshioka,Tomoaki Yoshikawa,Hiromi Nabeshi,Yasuo Tsutsumi, YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, PHARMACEUTICAL SOC JAPAN, Vol. 133, No. 2, p. 169-174, 2013/02
Resent Topics on Development of Nanomaterials and Nano-Safety Science Foreword, Yasuo Yoshioka,Yasuo Tsutsumi, YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, PHARMACEUTICAL SOC JAPAN, Vol. 133, No. 2, p. 149-150, 2013/02
Proteomic analysis of the hippocampus in Alzheimer's disease model mice by using two-dimensional fluorescence difference in gel electrophoresis, Masaoki Takano,Takuya Yamashita,Kazuya Nagano,Mieko Otani,Kouji Maekura,Haruhiko Kamada,Shin-ichi Tsunoda,Yasuo Tsutsumi,Takami Tomiyama,Hiroshi Mori,Kenji Matsuura,Shogo Matsuyama, NEUROSCIENCE LETTERS, ELSEVIER IRELAND LTD, Vol. 534, p. 85-89, 2013/02
Mutants of lymphotoxin-alpha with augmented cytotoxic activity via TNFR1 for use in cancer therapy, Tomohiro Morishige,Yasuo Yoshioka,Shogo Narimatsu,Shinji Ikemizu,Shin-ichi Tsunoda,Yasuo Tsutsumi,Yohei Mukai,Naoki Okada,Shinsaku Nakagawa, CYTOKINE, ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, Vol. 61, No. 2, p. 578-584, 2013/02
Robo4 is an effective tumor endothelial marker for antibody-drug conjugates based on the rapid isolation of the anti-Robo4 cell-internalizing antibody, Mai Yoshikawa,Yohei Mukai,Yoshiaki Okada,Yuki Tsumori,Shin-Ichi Tsunoda,Yasuo Tsutsumi,William C. Aird,Yasuo Yoshioka,Naoki Okada,Takefumi Doi,Shinsaku Nakagawa, Blood, American Society of Hematology, Vol. 121, No. 14, p. 2804-2813, 2013
Biochemical and hematologic effects of polyvinylpyrrolidone-wrapped fullerene C60 after oral administration, K. Yamashita,Y. Yoshioka,H. Pan,M. Taira,T. Ogura,T. Nagano,M. Aoyama,K. Nagano,Y. Abe,H. Kamada,S. I. Tsunoda,H. Aoshima,H. Nabeshi,T. Yoshikawa,Y. Tsutsumi, Pharmazie, Vol. 68, No. 1, p. 54-57, 2013/01
安全なナノマテリアルの開発に資するナノ安全科学研究の最前線, 永野貴士,堤康央,吉岡靖雄, 感染炎症免疫, 2012/12
The Safety Assessment of Nanomaterials for Development of Nano-cosmetics, Tokuyuki Yoshida,Yasuo Yoshioka,Yasuo Tsutsumi, YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, PHARMACEUTICAL SOC JAPAN, Vol. 132, No. 11, p. 1231-1236, 2012/11
Potential of acute-phase proteins as biomarkers for sub-nano platinum exposure, T. Nagano,Y. Yoshioka,K. Higashisaka,A. Kunieda,K. Hata,K. Nagano,Y. Abe,H. Kamada,S. Tsunoda,H. Nabeshi,T. Yoshikawa,Y. Tsutsumi, PHARMAZIE, GOVI-VERLAG PHARMAZEUTISCHER VERLAG GMBH, Vol. 67, No. 11, p. 958-959, 2012/11
Surface modification of amorphous nanosilica particles suppresses nanosilica-induced cytotoxicity, ROS generation, and DNA damage in various mammalian cells, Tokuyuki Yoshida,Yasuo Yoshioka,Keigo Matsuyama,Yasutaro Nakazato,Saeko Tochigi,Toshiro Hirai,Sayuri Kondoh,Kazuya Nagano,Yasuhiro Abe,Haruhiko Kamada,Shin-ichi Tsunoda,Hiromi Nabeshi,Tomoaki Yoshikawa,Yasuo Tsutsumi, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC ELSEVIER SCIENCE, Vol. 427, No. 4, p. 748-752, 2012/11
Amorphous silica nanoparticles enhance cross-presentation in murine dendritic cells, Toshiro Hirai,Yasuo Yoshioka,Hideki Takahashi,Ko-ichi Ichihashi,Tokuyuki Yoshida,Saeko Tochigi,Kazuya Nagano,Yasuhiro Abe,Haruhiko Kamada,Shin-ichi Tsunoda,Hiromi Nabeshi,Tomoaki Yoshikawa,Yasuo Tsutsumi, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC ELSEVIER SCIENCE, Vol. 427, No. 3, p. 553-556, 2012/10
Hemopexin as biomarkers for analyzing the biological responses associated with exposure to silica nanoparticles, Kazuma Higashisaka,Yasuo Yoshioka,Kohei Yamashita,Yuki Morishita,Huiyan Pan,Toshinobu Ogura,Takashi Nagano,Akiyoshi Kunieda,Kazuya Nagano,Yasuhiro Abe,Haruhiko Kamada,Shin-ichi Tsunoda,Hiromi Nabeshi,Tomoaki Yoshikawa,Yasuo Tsutsumi, NANOSCALE RESEARCH LETTERS, SPRINGER, Vol. 7, 2012/10
ナノ安全科学研究の最前線, 吉岡靖雄,堤康央, CICSJ Bulletin, 公益社団法人日本化学会・情報化学部会, Vol. 30, No. 3, p. 50-50, 2012/09
Amorphous nanosilica particles induce ROS generation in Langerhans cells, T. Yoshida,T. Yoshikawa,H. Nabeshi,K. Matsuyama,T. Hirai,T. Akase,Y. Yoshioka,N. Itoh,Y. Tsutsumi, PHARMAZIE, GOVI-VERLAG PHARMAZEUTISCHER VERLAG GMBH, Vol. 67, No. 8, p. 740-741, 2012/08
Dermal absorption of amorphous nanosilica particles after topical exposure for three days, T. Hirai,T. Yoshikawa,H. Nabeshi,T. Yoshida,T. Akase,Y. Yoshioka,N. Itoh,Y. Tsutsumi, PHARMAZIE, GOVI-VERLAG PHARMAZEUTISCHER VERLAG GMBH, Vol. 67, No. 8, p. 742-743, 2012/08
Suppression of nanosilica particle-induced inflammation by surface modification of the particles, Tomohiro Morishige,Yasuo Yoshioka,Hiroshi Inakura,Aya Tanabe,Shogo Narimatsu,Xinglei Yao,Youko Monobe,Takayoshi Imazawa,Shin-ichi Tsunoda,Yasuo Tsutsumi,Yohei Mukai,Naoki Okada,Shinsaku Nakagawa, ARCHIVES OF TOXICOLOGY, SPRINGER HEIDELBERG, Vol. 86, No. 8, p. 1297-1307, 2012/08
抗体プロテオミクス技術, 『臨床プロテオーム～個別医療を目指す臨床バイオマーカー探索～』, 鎌田春彦,堤康央,角田慎一, 金原出版, 2012/05
Distribution and histologic effects of intravenously administered amorphous nanosilica particles in the testes of mice, Yuki Morishita,Yasuo Yoshioka,Hiroyoshi Satoh,Nao Nojiri,Kazuya Nagano,Yasuhiro Abe,Haruhiko Kamada,Shin-ichi Tsunoda,Hiromi Nabeshi,Tomoaki Yoshikawa,Yasuo Tsutsumi, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC ELSEVIER SCIENCE, Vol. 420, No. 2, p. 297-301, 2012/04
Annexin A4 is a possible biomarker for cisplatin susceptibility of malignant mesothelioma cells, Takuya Yamashita,Kazuya Nagano,So-ichiro Kanasaki,Yuka Maeda,Takeshi Furuya,Masaki Inoue,Hiromi Nabeshi,Tomoaki Yoshikawa,Yasuo Yoshioka,Norio Itoh,Yasuhiro Abe,Haruhiko Kamada,Yasuo Tsutsumi,Shin-ichi Tsunoda, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC ELSEVIER SCIENCE, Vol. 421, No. 1, p. 140-144, 2012/04
ナノカーボンDDSの現状とその安全性確保に向けて, 平井敏郎,吉岡靖雄,堤康央, ドラッグデリバリーシステムの新展開Ⅱ -核酸医薬・抗体医薬・ワクチン医療を支えるDDS技術-, シーエムシー出版, 2012/03
Relation Analysis between Intracellular Distribution of Nanomateriarls, ROS Generation and DNA Damage, Tokuyuki Yoshida,Tomoaki Yoshikawa,Hiromi Nabeshi,Yasuo Tsutsumi, YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, PHARMACEUTICAL SOC JAPAN, Vol. 132, No. 3, p. 295-300, 2012/03
Rho GDP-dissociation inhibitor alpha is associated with cancer metastasis in colon and prostate cancer, T. Yamashita,T. Okamura,K. Nagano,S. Imai,Y. Abe,H. Nabeshi,T. Yoshikawa,Y. Yoshioka,H. Kamada,Y. Tsutsumi,S. Tsunoda, PHARMAZIE, GOVI-VERLAG PHARMAZEUTISCHER VERLAG GMBH, Vol. 67, No. 3, p. 253-255, 2012/03
Amorphous silica nanoparticles size-dependently aggravate atopic dermatitis-like skin lesions following an intradermal injection, Toshiro Hirai,Tomoaki Yoshikawa,Hiromi Nabeshi,Tokuyuki Yoshida,Saeko Tochigi,Ko-ichi Ichihashi,Miyuki Uji,Takanori Akase,Kazuya Nagano,Yasuhiro Abe,Haruhiko Kamada,Norio Itoh,Shin-ichi Tsunoda,Yasuo Yoshioka,Yasuo Tsutsumi, PARTICLE AND FIBRE TOXICOLOGY, BIOMED CENTRAL LTD, Vol. 9, 2012/02
Amorphous nanosilicas induce consumptive coagulopathy after systemic exposure, Hiromi Nabeshi,Tomoaki Yoshikawa,Keigo Matsuyama,Yasutaro Nakazato,Akihiro Arimori,Masaaki Isobe,Saeko Tochigi,Sayuri Kondoh,Toshiro Hirai,Takanori Akase,Takuya Yamashita,Kohei Yamashita,Tokuyuki Yoshida,Kazuya Nagano,Yasuhiro Abe,Yasuo Yoshioka,Haruhiko Kamada,Takayoshi Imazawa,Norio Itoh,Masuo Kondoh,Kiyohito Yagi,Tadanori Mayumi,Shin-ichi Tsunoda,Yasuo Tsutsumi, NANOTECHNOLOGY, IOP PUBLISHING LTD, Vol. 23, No. 4, 2012/02
Amorphous nanosilicas induce consumptive coagulopathy after systemic exposure, Hiromi Nabeshi,Tomoaki Yoshikawa,Keigo Matsuyama,Yasutaro Nakazato,Akihiro Arimori,Masaaki Isobe,Saeko Tochigi,Sayuri Kondoh,Toshiro Hirai,Takanori Akase,Takuya Yamashita,Kohei Yamashita,Tokuyuki Yoshida,Kazuya Nagano,Yasuhiro Abe,Yasuo Yoshioka,Haruhiko Kamada,Takayoshi Imazawa,Norio Itoh,Masuo Kondoh,Kiyohito Yagi,Tadanori Mayumi,Shin-ichi Tsunoda,Yasuo Tsutsumi, NANOTECHNOLOGY, IOP PUBLISHING LTD, Vol. 23, No. 4, 2012/02
Carbon Nanomaterials: Efficacy and Safety for Nanomedicine, Takuya Yamashita,Kohei Yamashita,Hiromi Nabeshi,Tomoaki Yoshikawa,Yasuo Yoshioka,Shin-ichi Tsunoda,Yasuo Tsutsumi, MATERIALS, MDPI AG, Vol. 5, No. 2, p. 350-363, 2012/02
Safety design of nanoparticle based-vaccine using protein corona, UDAKA Asako,YOSHIOKA Yasuo,YOSHIDA Tokuyuki,UJI Miyuki,MISATO Kazuki,MORI Takahide,HIRAI Toshiro,NAGANO Kazuya,ABE Yasuhiro,KAMADA Haruhiko,TSUNODA Shin-ichi,NABESHI Hiromi,YOSHIKAWA Tomoaki,TSUTSUMI Yasuo, Annual Meeting of the Japanese Society of Toxicology, The Japanese Society of Toxicology, Vol. 39, p. O-39, 2012
Safety evaluation of food nanomaterials based on intestinal flora variation, MORI Takahide,YOSHIOKA Yasuo,YOSHIDA Tokuyuki,UJI Miyuki,MISATO Kazuki,UDAKA Asako,HIRAI Toshiro,TSUNODA Shin-ichi,NABESHI Hiromi,YOSHIKAWA Tomoaki,TSUTSUMI Yasuo, Annual Meeting of the Japanese Society of Toxicology, The Japanese Society of Toxicology, Vol. 39, p. O-37, 2012
Analysis of amorphous nanosilica particles-mediated blood coagulation, YOSHIDA Tokuyuki,YOSHIOKA Yasuo,TOCHIGI Saeko,UJI Miyuki,MISATO Kazuki,UDAKA Asako,MORI Takahide,HIRAI Toshiro,TSUNODA Shin-ichi,NABESHI Hiromi,YOSHIKAWA Tomoaki,TSUTSUMI Yasuo, Annual Meeting of the Japanese Society of Toxicology, The Japanese Society of Toxicology, Vol. 39, p. O-30, 2012
The basic safety assessment of fullerenol by oral administration for the development of safe nanomedicine, YAMASHITA Kohei,YOSHIOKA Yasuo,PAN Huiyan,OGURA Toshinobu,TAIRA Mayu,AOYAMA Michihiko,TSUNODA Shin-ichi,NAKAYAMA Hiroyuki,FUJIO Shigeru,AOSHIMA Hisae,KOKUBO Ken,OSHIMA Takumi,NABESHI Hiromi,YOSHIKAWA Tomoaki,TSUTSUMI Yasuo, Annual Meeting of the Japanese Society of Toxicology, The Japanese Society of Toxicology, Vol. 39, p. O-36, 2012
Association between neutrophilia and inflammatory responses for ensuring safety of nanomaterials, HIGASHISAKA Kazuma,YOSHIOKA Yasuo,NAGANO Takashi,KUNIEDA Akiyoshi,HATA Katsutomo,TSUNODA Shin-ichi,NABESHI Hiromi,YOSHIKAWA Tomoaki,TSUTSUMI Yasuo, Annual Meeting of the Japanese Society of Toxicology, The Japanese Society of Toxicology, Vol. 39, p. O-23, 2012
Assessment of the microRNA-122 as a biomarker toward the developing of safety nanomaterials, NAGANO Takashi,YOSHIOKA Yasuo,HIGASHISAKA Kazuma,KUNIEDA Akiyoshi,HATA Katsutomo,TSUNODA Shin-ichi,NABESHI Hiromi,YOSHIKAWA Tomoaki,TSUTSUMI Yasuo, Annual Meeting of the Japanese Society of Toxicology, The Japanese Society of Toxicology, Vol. 39, p. O-38, 2012
Hazard identification of nano and sub-nano silver following nasal exposure, ICHIHASHI Ko-ichi,YOSHIOKA Yasuo,HIRAI Toshiro,TAKAHASHI Hideki,YOSHIDA Tokuyuki,TSUNODA Shin-ichi,NABESHI Hiromi,YOSHIKAWA Tomoaki,TSUTSUMI Yasuo, Annual Meeting of the Japanese Society of Toxicology, The Japanese Society of Toxicology, Vol. 39, p. O-26, 2012
Safety evaluation of sublingually administered nanomaterials and sub-nanomaterials, MISATO Kazuki,YOSHIOKA Yasuo,YOSHIDA Tokuyuki,UJI Miyuki,UDAKA Asako,MORI Takahide,HIRAI Toshiro,AKASE Takanori,TSUNODA Shin-ichi,NABESHI Hiromi,YOSHIKAWA Tomoaki,TSUTSUMI Yasuo, Annual Meeting of the Japanese Society of Toxicology, The Japanese Society of Toxicology, Vol. 39, p. O-27, 2012
Sub-nano materials might cause pregnancy complications in mice, SATO Hiroyoshi,YOSHIOKA Yasuo,MORISHITA Yuki,NOJIRI Nao,TSUNODA Shin-ichi,NABESHI Hiromi,YOSHIKAWA Tomoaki,TSUTSUMI Yasuo, Annual Meeting of the Japanese Society of Toxicology, The Japanese Society of Toxicology, Vol. 39, p. O-28, 2012
Dermal toxicity of subnano/nano-titanium in rats, KUWAGATA Makiko,MATSUMOTO Aki,KUMAGAI Fumiaki,SAITO Yoshiaki,MARUMO Hideki,NOGUCHI Satoshi,USUMI Kenji,CHISAKA Akiko,FURUYA Mami,SEKI Takayuki,KATOH Hiroyasu,TAKASHIMA Hiromasa,YOSHIDA Tokuyuki,YOSHIKAWA Tomoaki,YOSHIOKA Yasuo,TSUTSUMI Yasuo, Annual Meeting of the Japanese Society of Toxicology, The Japanese Society of Toxicology, Vol. 39, p. P-140, 2012
Hazard identification of exposure to nanomaterial in lactation period, YOSHIOKA Yasuo,NOJIRI Nao,MORISHITA Yuki,SATOH Hiroyoshi,TSUNODA Shin-ichi,NABESHI Hiromi,YOSHIKAWA Tomoaki,TSUTSUMI Yasuo, Annual Meeting of the Japanese Society of Toxicology, The Japanese Society of Toxicology, Vol. 39, p. P-138, 2012
Nanosilica-mediated enhancement of MHC class I-restricted cross-presentation, TAKAHASHI Hideki,YOSHIOKA Yasuo,HIRAI Toshiro,ICHIHASHI Ko-ichi,YOSHIDA Tokuyuki,TSUNODA Shin-ichi,NABESHI Hiromi,YOSHIKAWA Tomoaki,TSUTSUMI Yasuo, Annual Meeting of the Japanese Society of Toxicology, The Japanese Society of Toxicology, Vol. 39, p. P-137, 2012
The hazard identification of amorphous nanosilica particles following dermal applications using the atopic dermatitis model mouse, HIRAI Toshiro,YOSHIOKA Yasuo,ICHIHASHI Ko-ichi,TAKAHASHI Hideki,YOSHIDA Tokuyuki,TAKAGI Tatsuya,TSUNODA Shin-ichi,NABESHI Hiromi,YOSHIKAWA Tomoaki,TSUTSUMI Yasuo, Annual Meeting of the Japanese Society of Toxicology, The Japanese Society of Toxicology, Vol. 39, p. P-136, 2012
Intestinal absorption of amorphous nanosilica particles, UJI Miyuki,YOSHIOKA Yasuo,YOSHIDA Tokuyuki,MISATO Kazuki,UDAKA Asako,MORI Takahide,HIRAI Toshiro,TSUNODA Shin-ichi,NABESHI Hiromi,YOSHIKAWA Tomoaki,TSUTSUMI Yasuo, Annual Meeting of the Japanese Society of Toxicology, The Japanese Society of Toxicology, Vol. 39, p. P-134, 2012
Identification of new biomarkers for lung cancer by exploring proteins derived from exosomes, Kamada Haruhiko,Yamashita Takuya,Nagano Kazuya,Maeda Yuka,Abe Yasuhiro,Yoshikawa Tomoaki,Yoshioka Yasuo,Tsutsumi Yasuo,Tsunoda Shin-ichi, Abstracts for Annual Meeting of Japanese Proteomics Society, Japanese Proteomics Society (Japan Human Proteome Organisation), Vol. 2012, p. 145-145, 2012
Novel TNF-alpha Receptor 1 Antagonist Treatment Attenuates Arterial Inflammation and Intimal Hyperplasia in Mice, Manabu Kitagaki,Kikuo Isoda,Haruhiko Kamada,Takayuki Kobayashi,Shinichi Tsunoda,Yasuo Tsutsumi,Tomiharu Niida,Takehiko Kujiraoka,Norio Ishigami,Miya Ishihara,Osamu Matsubara,Fumitaka Ohsuzu,Makoto Kikuchi, JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, JAPAN ATHEROSCLEROSIS SOC, Vol. 19, No. 1, p. 36-46, 2012
Quantifying the biodistribution of nanoparticles, Tsutsumi Y,Yoshioka Y, Nature Nanotechnology, 2011/12
抗体プロテオミクス技術, 鎌田春彦,堤康央,角田慎一, 臨床プロテオーム～個別医療を目指す臨床バイオマーカー探索～, 2011/12
ナノカーボンDDSの可能性と安全性, 平井敏郎,吉岡靖雄,堤康央, 『ドラッグデリバリーシステムの新展開? -核酸医薬・抗体医薬・ワクチン医療を支えるDDS技術-』, 2011/12
Relation analysis between intracellular distribution of nanomateriarls, ROS generation and DNA damage., Yoshida T,Yoshikawa T,Tsutsumi Y, Yakugaku Zasshi, 2011/12
自己免疫疾患に対するタンパク医薬とDDS, 鎌田春彦,堤康央,角田慎一, 自己免疫疾患に対するタンパク医薬とDDS, シーエムシー出版, 2011/12
Structure-activity relationship of T-cell receptors based on alanine scanning, Shogo Narimatsu,Yasuo Yoshioka,Tomohiro Morishige,Xinglei Yao,Shin-ichi Tsunoda,Yasuo Tsutsumi,Michael I. Nishimura,Yohei Mukai,Naoki Okada,Shinsaku Nakagawa, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC ELSEVIER SCIENCE, Vol. 415, No. 4, p. 558-562, 2011/12
Lysine-deficient lymphotoxin-alpha mutant for site-specific PEGylation, Shogo Narimatsu,Yasuo Yoshioka,Hikaru Watanabe,Takashi Masano,Tomohiro Morishige,Xinglei Yao,Aya Tanabe,Shin-ichi Tsunoda,Yasuo Tsutsumi,Yohei Mukai,Naoki Okada,Shinsaku Nakagawa, CYTOKINE, ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, Vol. 56, No. 2, p. 489-493, 2011/11
Biological and structural characterization of human TNFR2-selective TNF mutants, Abe Yasuhiro,Inoue Masaki,Furuya Takeshi,Mukai Yohei,Nakamura Teruya,Yamagata Yuriko,Nabeshi Hiromi,Yoshikawa Tomoaki,Yoshioka Yasuo,Nagano Kazuya,Kamada Haruhiko,Tsutsumi Yasuo,Tsunoda Shin-ichi, CYTOKINE, Vol. 56, No. 1, 2011/10
Creation of mouse TNFR2-selective TNF mutant using phage display system, Furuya Takeshi,Abe Yasuhiro,Inoue Masaki,Nabeshi Hiromi,Yoshikawa Tomoaki,Yoshioka Yasuo,Itoh Norio,Nagano Kazuya,Kamada Haruhiko,Tsutsumi Yasuo,Tsunoda Shin-ichi, CYTOKINE, Vol. 56, No. 1, 2011/10
不育症オーバービュー, 齋藤滋,杉浦真弓,丸山哲夫,田中忠夫,竹下俊行,山田秀人,小澤伸晃,中塚幹也,木村正,藤井知行,下屋浩一郎,山本樹生,佐田文宏,康東天,早川智,一瀬白帝,柳原格,秦健一郎,勝山博信,堤康央,中野有美,福井淳史,杉俊隆, 産婦人科の実際『不育症特集』, 金原出版, 2011/10
ナノ安全科学研究の最前線, 東阪和馬,堤康央, 月刊『化学』, 株式会社化学同人, 2011/09
Safety of nanomaterials in the field of perfumery and cosmetics, Cosmetic stage, Vol. 5, No. 8, p. 45-49, 2011/08
Development of a novel DDS for site-specific PEGylated proteins, Yasuo Yoshioka,Shin-ichi Tsunoda,Yasuo Tsutsumi, CHEMISTRY CENTRAL JOURNAL, BIOMED CENTRAL LTD, Vol. 5, 2011/05
Systemic distribution, nuclear entry and cytotoxicity of amorphous nanosilica following topical application, Hiromi Nabeshi,Tomoaki Yoshikawa,Keigo Matsuyama,Yasutaro Nakazato,Kazuhiko Matsuo,Akihiro Arimori,Masaaki Isobe,Saeko Tochigi,Sayuri Kondoh,Toshiro Hirai,Takanori Akase,Takuya Yamashita,Kohei Yamashita,Tokuyuki Yoshida,Kazuya Nagano,Yasuhiro Abe,Yasuo Yoshioka,Haruhiko Kamada,Takayoshi Imazawa,Norio Itoh,Shinsaku Nakagawa,Tadanori Mayumi,Shin-ichi Tsunoda,Yasuo Tsutsumi, BIOMATERIALS, ELSEVIER SCI LTD, Vol. 32, No. 11, p. 2713-2724, 2011/04
Conformational and functional analysis for quality control of biologics using ion mobility mass spectrometry, Kamada Haruhiko,Nagano kazuya,Abe Yasuhiro,Inoue Masaki,Tsutsumi Yasuo,Naka Tetsuji,Tsunoda Shin-ichi, Abstracts for Annual Meeting of Japanese Proteomics Society, Japanese Proteomics Society (Japan Human Proteome Organisation), Vol. 2011, p. 197-197, 2011
Anti-inflammatory Effects of a Novel TNFR1-Selective Antagonistic TNF Mutant on Established Murine Collagen-Induced Arthritis, Yasuhiro Abe,Tetsuya Nomura,Yasuo Yoshioka,Haruhiko Kamada,Shin-ichi Tsunoda,Yasuo Tsutsumi, ADVANCES IN TNF FAMILY RESEARCH, SPRINGER-VERLAG BERLIN, Vol. 691, p. 493-500, 2011
CREATION OF MUTANT LYMPHOTOXIN-ALPHAS WITH ENHANCED BIOACTIVITIES BY PHAGE DISPLAY TECHNIQUE, Yoshioka Yasuo,Watanabe Hikaru,Tsutsumi Yasuo,Mukai Yohei,Okada Naoki,Nakagawa Shinsaku, ADVANCES IN TNF FAMILY RESEARCH, Vol. 691, 2011
RECEPTOR INTERACTION OF TUMOR NECROSIS FACTOR (TNF) BASED ON 3D STRUCTURAL ANALYSIS OF A FULLY ACTIVE TNFR1-SELECTIVE TNF MUTANT, Mukai Yohei,Nakamura Teruya,Yoshioka Yasuo,Abe Yasuhiro,Nomura Tetsuya,Taniai Madoka,Ohta Tsunetaka,Ikemizu Shinji,Nakagawa Shinsaku,Tsunoda Shin-ichi,Kamada Haruhiko,Yamagata Yuriko,Tsutsumi Yasuo, ADVANCES IN TNF FAMILY RESEARCH, Vol. 691, 2011
THE DEVELOPMENT OF FULLY ACTIVE RECEPTOR-SELECTIVE TUMOR NECROSIS FACTOR (TNF) MUTANTS, Yoshikawa Mai,Mukai Yohei,Shibata Hiroko,Yoshioka Yasuo,Abe Yasuhiro,Nomura Tetsuya,Taniai Madoka,Ohta Tsunetaka,Tsunoda Shin-ichi,Kamada Haruhiko,Nakagawa Shinsaku,Tsutsumi Yasuo, ADVANCES IN TNF FAMILY RESEARCH, Vol. 691, 2011
Development of functional cytokine mutants bymolecular evolution and drug delivery technology, Shin-ichi Tsunoda,Yasuo Tsutsumi, Drug Delivery System, Vol. 26, No. 6, p. 604-610, 2011
Doxorubicin-loaded PEG-PCL copolymer micelles enhance cytotoxicity and intracellular accumulation of doxorubicin in adriamycin-resistant tumor cells, Yuan-Yuan Diao,Hao-Ying Li,Ying-Hua Fu,Min Han,Yu-Lan Hu,Hong-Liang Jiang,Yasuo Tsutsumi,Qi-Chun Wei,Da-Wei Chen,Jian-Qing Gao, INTERNATIONAL JOURNAL OF NANOMEDICINE, DOVE MEDICAL PRESS LTD, Vol. 6, p. 1955-1962, 2011
TNF-alpha Receptor 1 Antagonist Treatment Attenuates Arterial Inflammation and Intimal Hyperplasia in Interleukin-1 Receptor Antagonist Deficient Mice, Kikuo Isoda,Manabu Kitagaki,Haruhiko Kamada,Shinichi Tsunoda,Yasuo Tsutsumi,Tomiharu Niida,Norio Ishigami,Miya Ishihara,Makoto Kikuchi,Fumitaka Ohsuzu, CIRCULATION, LIPPINCOTT WILLIAMS & WILKINS, Vol. 122, No. 21, 2010/11
Anti-inflammatory effects of a novel TNFR1-selective antagonistic TNF mutant in murine experimental autoimmune encephalomyelitis, Abe Yasuhiro,Nomura Tetsuya,Inoue Masaki,Arita Shu-hei,Furuya Takeshi,Yoshikawa Tomoaki,Yoshioka Yasuo,Nagano Kazuya,Kamada Haruhiko,Tsutsumi Yasuo,Tsunoda Shin-ichi, CYTOKINE, Vol. 52, No. 1-2, 2010/10
The potential use of IL-1 family cytokines as mucosal adjuvants for a NASA influenza vaccine, Arita Shu-hei,Kayamuro Hiroyuki,Abe Yasuhiro,Yoshioka Yasuo,Kamada Haruhiko,Furuya Tsuyoshi,Itoh Norio,Yoshikawa Tomoaki,Nagano Kazuya,Tsutsumi Yasuo,Tsunoda Shin-ichi, CYTOKINE, Vol. 52, No. 1-2, p. 89-90, 2010/10
Arsenic trioxide induces down-regulation of gp46 via protein oxidation: Proteomics analysis of oxidative modified proteins in As2O 3-treated HTLV-1-infected cells, H. Nabeshi,T. Yoshikawa,H. Kamada,H. Shibata,T. Sugita,Y. Abe,K. Nagano,T. Nomura,K. Minowa,Shin-Ichi Tsunoda,Yasuo Tsutsumi, Pharmazie, Vol. 65, No. 9, p. 702-707, 2010/09
Creation of a LIGHT mutant with the capacity to evade the decoy receptor using phage display technique, Tomohiro Morishige,Yasuo Yoshioka,Hiroshi Inakura,Aya Tanabe,Xinglei Yao,Shin-ichi Tsunoda,Yasuo Tsutsumi,Yohei Mukai,Naoki Okada,Shinsaku Nakagawa, Biomaterials, Vol. 31, No. 12, p. 3357-3363, 2010/04
Arsenic trioxide induces down-regulation of gp46 via protein oxidation: proteomics analysis of oxidative modified proteins in As2O3-treated HTLV-1-infected cells, Nabeshi H,Yoshikawa T,Kamada H,Shibata H,Sugita T,Abe Y,Nagano K,Nomura T,Minowa K,Tsunoda S,Tsutsumi Y, Pharmazie, Vol. 65, No. 9, p. 702-707, 2010
TNFR1-selectivity improvement of mutant TNF with antagonistic activity, Nomura Tetsuya,Abe Yasuhiro,Inoue Masaki,Yoshioka Yasuo,Kayamuro Hiroyuki,Mukai Yohei,Taniai Madoka,Ohta Tsunetaka,Nakagawa Shinsaku,Kamada Haruhiko,Tsunoda Shin-ichi,Tsutsumi Yasuo, CYTOKINE, ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, Vol. 48, No. 1-2, p. 73-73, 2009/10
Characterization of mucosal and systemic immune responses elicited by interleukin cytokines as mucosal adjuvant against influenza virus, Kayamuro Hiroyuki,Yoshioka Yasuo,Abe Yasuhiro,Arita Shu-hei,Katayama Kazufumi,Kamada Haruhiko,Nomura Tetsuya,Itoh Norio,Yoshikawa Tomoaki,Nagano Kazuya,Tsunoda Shin-ich,Tsutsumi Yasuo, CYTOKINE, Vol. 48, No. 1-2, 2009/10
Mast cells are required for interleukin-18 dependent mucosal immune responses, Abe Yasuhiro,Kayamuro Hiroyuki,Yoshioka Yasuo,Arita Shu-hei,Kamada Haruhiko,Nomura Tetsuya,Itoh Norio,Yoshikawa Tomoaki,Nagano Kazuya,Tsunoda Shin-ich,Tsutsumi Yasuo, CYTOKINE, Vol. 48, No. 1-2, 2009/10
Hepatotoxicity of silica nanoparticles in mice, Yagi Kiyohito,Nishimori Hikaru,Kondoh Masuo,Isoda Katsuhiro,Tsunoda Shin-ichi,Tsutsumi Yasuo, TOXICOLOGY LETTERS, Vol. 189, 2009/09/13
Nanosilicas with different sizes and surface charges induce different profiles of cytokine production on macrophages, Yoshioka Yasuo,Morishige Tomohiro,Tanabe Aya,Tsutsumi Yasuo,Mukai Yohei,Okada Naoki,Nakagawa Shinsaku, TOXICOLOGY LETTERS, Vol. 189, 2009/09/13
NK cells are migrated and indispensable in the anti-tumor activity induced by CCL27 gene therapy., Gao JQ,Tsuda Y,Han M,Xu DH,Kanagawa N,Hatanaka Y,Tani Y,Mizuguchi H,Tsutsumi Y,Mayumi T,Okada N,Nakagawa S, Cancer immunology, immunotherapy : CII, Vol. 58, No. 2, p. 291-299, 2009/02
CREATION OF MUTANT LYMPHOTOXIN-ALPHAS WITH ENHANCED BIOACTIVITIES BY PHAGE DISPLAY TECHNIQUE, Yoshioka Yasuo,Watanabe Hikaru,Tsutsumi Yasuo,Mukai Yohei,Okada Naoki,Nakagawa Shinsaku, JOURNAL OF PHYSIOLOGICAL SCIENCES, Vol. 59, 2009
Fine tuning of receptor-selectivity for TNF using a phage display system with one-step competitive-subtractive panning, Abe Yasuhiro,Shibata Hiroko,Nomura Tetsuya,Kayamuro Hiroyuki,Mukai Yohei,Yoshikawa Tomoaki,Yoshioka Yasuo,Taniai Madoka,Ohta Tsunetaka,Nakagawa Shinsaku,Kamada Haruhiko,Tsunoda Shin-ichi,Tsutsumi Yasuo, CYTOKINE, ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD, Vol. 43, No. 3, p. 294-295, 2008/09
Creation of mutant TNF with TNF receptor-1 selective antagonistic activity for the development of a novel autoimune disease drug, Nomura Tetsuya,Abe Yasuhiro,Yoshioka Yasuo,Shibata Hiroko,Kayamuro Hiroyuki,Mukai Yohei,Taniai Madoka,Ohta Tsunetaka,Nakagawa Shinsaku,Kamada Haruhiko,Tsunoda Shin-ichi,Tsutsumi Yasuo, CYTOKINE, ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD, Vol. 43, No. 3, p. 259-259, 2008/09
Structure-function relationship of TNF based on 3D structural analysis of fully active TNFR1-selective TNF mutant, Mukai Yohei,Shibata Hiroko,Nakamura Teruya,Yoshioka Yasuo,Abe Yasuhiro,Nomura Tetsuya,Taniai Madoka,Ohta Tsunetaka,Ikemizu Shinji,Nakagawa Shinsaku,Tsunoda Shin-ichi,Kamada Haruhiko,Yamagata Yuriko,Tsutsumi Yasuo, CYTOKINE, ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD, Vol. 43, No. 3, p. 295-295, 2008/09
Relationship between regulatory T-cell infiltration and progression of different tumors assessed by high-density tissue microarray, Nagano Kazuya,Yoshikawa Tomoaki,Sugita Toshiki,Nabeshi Hiromi,Imai Sunao,Suzuki Kensuke,Fukuoka Junya,Nakagawa Shinsaku,Abe Yasuhiro,Kamada Haruhiko,Tsunoda Shin-ichi,Tsutsumi Yasuo, CYTOKINE, Vol. 43, No. 3, 2008/09
Comparative study on transduction and toxicity of protein transduction domains., Sugita T,Yoshikawa T,Mukai Y,Yamanada N,Imai S,Nagano K,Yoshida Y,Shibata H,Yoshioka Y,Nakagawa S,Kamada H,Tsunoda SI,Tsutsumi Y, Br J Pharmacol., 2008/03
3P-081 Creation of TNFR1-selective mutant lymphotoxin alpha using phage display system(The 46th Annual Meeting of the Biophysical Society of Japan), Watanabe Hikaru,Yoshioka Yasuo,Morishige Tomohiro,Tsunoda Shin-ichi,Tsutsumi Yasuo,Mukai Yohei,Okada Naoki,Nakagawa Shinsaku, Seibutsu Butsuri, The Biophysical Society of Japan General Incorporated Association, Vol. 48, p. S139-S140, 2008
Creation and X-ray structure analysis of the tumor necrosis factor receptor-1-selective mutant of a tumor necrosis factor-alpha antagonist., Shibata H,Yoshioka Y,Ohkawa A,Minowa K,Mukai Y,Abe Y,Taniai M,Nomura T,Kayamuro H,Nabeshi H,Sugita T,Imai S,Nagano K,Yoshikawa T,Fujita T,Nakagawa S,Yamamoto A,Ohta T,Hayakawa T,Mayumi T,Vandenabeele P,Aggarwal BB,Nakamura T,Yamagata Y,Tsunoda S,Kamada H,Tsutsumi Y, J Biol Chem., Vol. 283, p. 998-1007, 2008/01
Effective tumor targeted gene transfer using PEGylated adenovirus vector via systemic administration., Gao JQ,Eto Y,Yoshioka Y,Sekiguchi F,Kurachi S,Morishige T,Yao X,Watanabe H,Asavatanabodee R,Sakurai F,Mizuguchi H,Okada Y,Mukai Y,Tsutsumi Y,Mayumi T,Okada N,Nakagawa S, J Control Release., Vol. 122, No. 1, p. 102-10, 2007/09
Role of amino acid residue 90 in bioactivity and receptor binding capacity of tumor necrosis factor mutants., Hiroko Shibata,Haruhiko Kamada,Kyoko Kobayashi-Nishibata,Yasuo Yoshioka,Toshihide Nishibata,Yasuhiro Abe,Tetsuya Nomura,Hiromi Nabeshi,Kyoko Minowa,Yohei Mukai,Shinsaku Nakagawa,Tadanori Mayumi,Shin-Ichi Tsunoda,Yasuo Tsutsumi, Biochimica et biophysica acta, Vol. 1774, No. 8, p. 1029-35, 2007/08
Development of the valuable cell line which evaluate the bioactivity through TNFR2 using chimeric receptor strategy, Abe Yasuhiro,Yoshioka Yasuo,Nomura Tetsuya,Nabeshi Hiromi,Kayamuro Hiroyuki,Minowa Kyoko,Shibata Hiroko,Nakagawa Shinsaku,Kamada Haruhiko,Tsunoda Shin-Ichi,Tsutsumi Yasuo, CYTOKINE, Vol. 39, No. 1, 2007/07
Site-specific PEGylation of a lysine-deficient TNF superfamily with full bioactivity, Yoshioka Yasuo,Morishige Tomohiro,Watanabe Hikaru,Tanabe Aya,Abe Yasuhiro,Mukai Yohei,Kamada Harubiko,Okada Naoki,Nakagawa Shinsaku,Tsutsumi Yasuo, CYTOKINE, Vol. 39, No. 1, 2007/07
Simultaneous identification of tumor-specific proteins and their antibodies by combining a proteomics technique and phage display library, Yoshikawa Tomoaki,Imai Sunao,Nagano Kazuya,Sugita Toshiki,Mukai Yohei,Nakagawa Shinsaku,Kamada Haruhiko,Tsunoda Shin-ichi,Tsutsumi Yasuo, CYTOKINE, Vol. 39, No. 1, 2007/07
Role of amino acid residue 90 in bioactivity and receptor binding capacity of tumor necrosis factor mutants, Kamada Haruhiko,Tsutsumi Yasuo,Yoshioka Yasuo,Shibata Hiroko,Abe Yasuhiro,Nomura Tetsuya,Minowa Kyoko,Nabeshi Hiromi,Nakagawa Shinsaku,Tsunoda Shin-ichi, Abstracts for Annual Meeting of Japanese Proteomics Society, Japanese Proteomics Society (Japan Human Proteome Organisation), Vol. 2007, No. 0, p. 154-154, 2007
[Development of nanomedicine using intracellular DDS]., Yoshikawa T,Tsutsumi Y,Nakagawa S, Nihon rinsho. Japanese journal of clinical medicine, Vol. 64, No. 2, p. 247-252, 2006/02
体内動態制御を目指したポリエチレングリコール修飾アデノウイルスベクターの腫瘍集積性に関する検討, 衛藤佑介,高建青,倉知慎之輔,森重智弘,櫻井文教,水口裕之,早川尭夫,堤康央,真弓忠範,中川晋作, 薬剤学: 生命とくすり, (公社)日本薬剤学会, Vol. 65, No. Suppl., p. 178-178, 2005/03
Effective accumulation of poly(vinylpyrrolidone-co-vinyl laurate) into the spleen., Yasuo Yoshioka,Yasuo Tsutsumi,Yohei Mukai,Hiroko Shibata,Takayuki Okamoto,Yoshihisa Kaneda,Shin-ichi Tsunoda,Haruhiko Kamada,Keiichi Koizumi,Yoko Yamamoto,Yu Mu,Hiroshi Kodaira,Keiko Sato-Kamada,Shinsaku Nakagawa,Tadanori Mayumi, Journal of biomedical materials research. Part A, Vol. 70, No. 2, p. 219-23, 2004/08/01
Combination effects of complement regulatory proteins and anti-complement polymer., Yasuo Yoshioka,Ryo Suzuki,Takayuki Okamoto,Naoki Okada,Yohei Mukai,Hiroko Shibata,Yasuo Tsutsumi,Natsuki Dohi,Noriko Okada,Shinsaku Nakagawa,Tadanori Mayumi, Biochimica et biophysica acta, Vol. 1624, No. 1-3, p. 54-9, 2003/12/05
遺伝子治療の最適化を目指したポリエチレングリコール修飾アデノウイルスベクターの血中滞留性に関する検討, 衛藤佑介,関口文子,高建青,形山和史,堤康央,櫻井文教,水口裕之,早川尭夫,真弓忠範,中川晋作, Drug Delivery System, 日本DDS学会, Vol. 18, No. 3, p. 249-249, 2003/05
癌ミサイル療法の最適化に向けたImmunotoxinの部位特異的バイオコンジュゲーションに関する検討, 向洋平,吉岡靖雄,岡本貴行,吉川友章,柴田寛子,清水智絵,川村真紀,堤康央,中川晋作,真弓忠範, Drug Delivery System, 日本DDS学会, Vol. 18, No. 3, p. 265-265, 2003/05
Development of a novel cytomedical treatment that can protect entrapped cells from host humoral immunity., Suzuki R,Yoshioka Y,Kitano E,Yoshioka T,Oka H,Okamoto T,Okada N,Tsutsumi Y,Nakagawa S,Miyazaki J,Kitamura H,Mayumi T, Cell Transplant., Vol. 11, No. 8, p. 787-97, 2002/11
A conjugate from a laminin-related peptide, Tyr-IIe-Gly-Ser-Arg, and chitosan: Efficient and regioselective conjugation and significant inhibitory activity against experimental cancer metastasis, Yasuhiro Nishiyama,Tomoko Yoshikawa,Nobumichi Ohara,Keisuke Kurita,Kciko Hojo,Haruhiko Kamada,Yasuo Tsutsumi,Tadanori Mayumi,Koichi Kawasaki, Journal of the Chemical Society, Perkin Transactions 1, No. 7, p. 1161-1165, 2000
A conjugate from a laminin-related peptide, Tyr-Ile-Gly-Ser-Arg, and chitosan: efficient and regioselective conjugation and significant inhibitory activity against experimental cancer metastasis, Y Nishiyama,T Yoshikawa,N Ohara,K Kurita,K Hojo,H Kamada,Y Tsutsumi,T Mayumi,K Kawasaki, JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, ROYAL SOC CHEMISTRY, No. 7, p. 1161-1165, 2000
A novel vaccine delivery system using immunopotentiating fusogenic liposomes., Hayashi A,Nakanishi T,Kunisawa J,Kondoh M,Imazu S,Tsutsumi Y,Tanaka K,Fujiwara H,Hamaoka T,Mayumi T, Biochem Biophys Res Commun, Vol. 261, No. 3, p. 824-828, 1999/08
Positively charged liposome functions as an efficient immunoadjuvant in inducing immune responses to soluble proteins., Nakanishi T,Kunisawa J,Hayashi A,Tsutsumi Y,Kubo K,Nakagawa S,Fujiwara H,Hamaoka T,Mayumi T, Biochem Biophys Res Commun, Vol. 240, No. 3, p. 793-797, 1997/11
Preparation of laminin-related peptide analogs and their inhibitory effect on experimental metastasis in mice, Y Izuno,M Kakiuchi,M Maeda,K Kawasaki,Y Kaneda,Y Tsutsumi,S Nakagawa,T Mayumi, PEPTIDE CHEMISTRY 1995, PROTEIN RESEARCH FOUNDATION, p. 401-404, 1996
ラミニンおよびフィブロネクチン関連ペプチドの合成と腫瘍細胞転移抑制作用, 川崎紘一,前田光子,柿内雅,金田喜久,堤康央,中川晋作,真弓忠範, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 115年会, No. 2, p. 268-268, 1995/03

Misc.

粘膜吸収促進剤の安全性評価の現状と課題, 白霖,桂田剛志,橘敬祐,日下部哲也,堤康央,近藤昌夫, レギュラトリーサイエンス学会誌, Vol. 13, No. 3, p. 1-14, 2023/01
クルクミンの活性は、最初に分散・溶解させる溶媒によって変化する, 長野一也,前北光,平井はるな,中尾友洋,木下圭剛,坂田慎,西野雅之,辻野博文,東阪和馬,堤康央, 日本食品化学学会誌, Vol. 29, No. 3, p. 179-183, 2022/12
Health effects of fine particle exposure on vulnerable generations, BIO Clinica, Vol. 37, No. 1, p. 59-63, 2022/01
Regulatory Considerations of Conditional Approval for Balancing Pre-market and Post-market Evaluations to Achieve Early Patient Access to Medical Products in Japan, 松下俊介,橘敬祐,日下部哲也,日下部哲也,堤康央,近藤昌夫, レギュラトリーサイエンス学会誌, Vol. 11, No. 2, 2021
Current situation and challenges of a regulatory concept of pharmacokinetics focusing on microbiome, 庄真喜子,橘敬祐,原田和生,平田收正,堤康央,國澤純,國澤純,國澤純,國澤純,國澤純,國澤純,近藤昌夫, 腸内細菌学雑誌, Vol. 35, No. 2, 2021
Overview of the pre‐ and post‐marketing requirements for drugs granted Japanese conditional marketing approval, Shunsuke Matsushita,Keisuke Tachibana,Tetsuya Kusakabe,Ryuichi Hirayama,Yasuo Tsutsumi,Masuo Kondoh, Clinical and Translational Science, Wiley, 2020/10/13
腸内細菌叢による薬物代謝に着目したファーマコゲノミクス解析のレギュラトリーサイエンス, 庄真喜子,橘敬祐,太田翔平,原田和生,平田收正,堤康央,國澤純,國澤純,國澤純,國澤純,國澤純,近藤昌夫, レギュラトリーサイエンス学会誌, Vol. 10, No. Supplement, 2020
The role of alpha B-crystallin in chemotherapy-induced migration of triple negative breast cancer, Lili Yang,Kazuma Higashisaka,Yuya Haga,Naoki Sekine,Kotoe Kiyomoto,Ying Lin,Hirofumi Tsujino,Kazuya Nagano,Yasuo Tsutsumi, MOLECULAR CANCER THERAPEUTICS, AMER ASSOC CANCER RESEARCH, Vol. 18, No. 12, 2019/12
心分泌蛋白質に着目した心不全に対する新規バイオマーカー探索, 東阪和馬,東阪和馬,大須賀絵理,笠原淳平,豊田麻人,尾花理徳,鎌田春彦,前田真貴子,長野一也,藤尾慈,藤尾慈,藤尾慈,坂田泰史,坂田泰史,堤康央,堤康央, 日本薬学会年会要旨集(CD-ROM), (公社)日本薬学会, Vol. 138th, No. 4, p. ROMBUNNO.27G‐pm06-61, 2018/03
慢性腎臓病に対する診断バイオマーカーの確立に向けた腎分泌蛋白質の有用性評価, 石田菜南,東阪和馬,東阪和馬,竹谷苑子,井阪亮,尾花理徳,鎌田春彦,前田真貴子,長野一也,藤尾慈,藤尾慈,藤尾慈,神出計,神出計,堤康央,堤康央, 日本薬学会年会要旨集(CD-ROM), (公社)日本薬学会, Vol. 138th, No. 4, p. ROMBUNNO.28PA‐pm318-188, 2018/03
非小細胞肺がんにおけるEGFRチロシンキナーゼ阻害剤の耐性化機構の解明に向けた検討, 林穎,東阪和馬,新谷拓也,花室紗知代,芳賀優弥,前田真一郎,長野一也,藤尾慈,堤康央, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 138年会, No. 4, p. 65-65, 2018/03
ホルモン受容体関連蛋白質に着目した、肺がんにおけるEGFRチロシンキナーゼ阻害剤の耐性化機構の解明, 花室紗知代,東阪和馬,林穎,新谷拓也,芳賀優弥,前田真一郎,長野一也,藤尾慈,堤康央, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 138年会, No. 4, p. 194-194, 2018/03
心不全に対する新規診断法の開発に向けたバイオマーカーの探索, 大須賀絵理,東阪和馬,笠原淳平,豊田麻人,鎌田春彦,前田真貴子,長野一也,藤尾慈,藤尾慈,藤尾慈,坂田泰史,坂田泰史,堤康央,堤康央, 日本薬学会年会要旨集(CD-ROM), (公社)日本薬学会, Vol. 137th, No. 4, p. ROMBUNNO.25PB‐am216S-111, 2017/03
肺がんにおけるEGFRチロシンキナーゼ阻害剤の耐性化機序の解明に向けた検討, 林穎,東阪和馬,真木彩花,新谷拓也,前田真一郎,長野一也,藤尾慈,堤康央, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 137年会, No. 4, p. 105-105, 2017/03
慢性腎臓病の早期診断に向けた新規バイオマーカーの探索, 竹谷苑子,東阪和馬,井阪亮,石田菜南,鎌田春彦,尾花理徳,前田真貴子,長野一也,楽木宏実,藤尾慈,神出計,堤康央, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 137年会, No. 4, p. 112-112, 2017/03
抗体の親和性向上による生体影響の評価に向けた基礎的検討, 竹谷苑子,長野一也,森宣瑛,永野貴士,向井美穂,大須賀絵理,芳賀優弥,井阪亮,鎌田春彦,角田慎一,南谷武春,安居輝人,堤康央, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 136年会, No. 3, p. 144-144, 2016/03
Neutrophil depletion increase silica nanoparticle-induced placental cellular damage, K. Higashisaka,Y. Iwahara,I. Yanagihara,S. Saito,Y. Yoshioka,Y. Tsutsumi, TOXICOLOGY LETTERS, ELSEVIER IRELAND LTD, Vol. 238, No. 2, p. S206-S206, 2015/10
健康・医療戦略推進法の与えるインパクト先端的研究開発の実現に向けてアカデミア創薬の研究教育に係る「阪大薬学丸」の挑戦, 堤康央,小比賀聡,宇野公之,土井健史,藤尾慈, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 135年会, No. 1, p. 309-309, 2015/03
Optimization of an immune method to shorten time for inducing antibodies in mice, T. Mori,K. Nagano,K. Higashisaka,Y. Yoshioka,H. Kamada,S. Tsunoda,Y. Tsutsumi, MOLECULAR BIOLOGY OF THE CELL, AMER SOC CELL BIOLOGY, Vol. 26, 2015
ナノ白金粒子と医薬品成分・化学物質の相互作用に関する検討, 大坊萌美,磯田勝広,油科香里,長谷川知也,吉岡靖雄,堤康央,石田功, 日本薬学会年会要旨集(CD-ROM), Vol. 135th, 2015
Effect of toxicity and drug interactions by nano-platinum particles, ISODA Katsuhiro,DAIBO Tomomi,YUSHINA Kaori,TAIRA Yuitiro,TAIRA Ikuko,YOSHIOKA Yasuo,TSUTSUMI Yasuo,ISHIDA Isao, Annual Meeting of the Japanese Society of Toxicology, The Japanese Society of Toxicology, Vol. 42, No. 0, p. P-96, 2015
Antibody base proteomics for discovery of disease-related biomarker, Vol. 251, No. 10, p. 1023-1028, 2014/12/06
Single particle tracking method for the analysis of intracellular movement of the silica nanoparticles, Michihiko Aoyama,Yasuo Yoshioka,Yoshiyuki Arai,Rio Ishimoto,Shin-ichi Tsunoda,Kazuma Higashisaka,Takeharu Nagai,Yasuo Tsutsumi, TOXICOLOGY LETTERS, ELSEVIER IRELAND LTD, Vol. 229, p. S186-S187, 2014/09
The contribution of silica nanoparticles-induced neutrophilia to pregnancy complications in mice, Kazuma Higashisaka,Akiyoshi Kunieda,Yuki Iwahara,Kota Tanaka,Shin-ichi Tsunoda,Yasuo Yoshioka,Yasuo Tsutsumi, TOXICOLOGY LETTERS, ELSEVIER IRELAND LTD, Vol. 229, p. S193-S193, 2014/09
Expression of Annexin A4 regulates cisplatin-susceptibility in malignant mesothelioma, K. Nagano,T. Yamashita,M. Inoue,K. Higashisaka,Y. Yoshioka,Y. Abe,Y. Mukai,H. Kamada,Y. Tsutsumi,S. Tsunoda, EUROPEAN JOURNAL OF CANCER, ELSEVIER SCI LTD, Vol. 50, p. S190-S190, 2014/07
Silver nanoparticles induce silver nanoparticle-specific allergic responses, Toshiro Hirai,Yasuo Yoshioka,Ko-ichi Ichihashi,Takahide Mori,Nobuo Nishijima,Takayuki Handa,Hideki Takahashi,Shin-ichi Tsunoda,Kazuma Higashisaka,Yasuo Tsutsumi, JOURNAL OF IMMUNOLOGY, AMER ASSOC IMMUNOLOGISTS, Vol. 192, 2014/05
Fullerene C60 derivatives suppress the acquired immune responses, Yasuo Yoshioka,Asako Udaka,Toshiro Hirai,Hisae Aoshima,Ken Kokubo,Takumi Oshima,Tomoyuki Ohe,Tadahiko Mashino,Shin-ichi Tsunoda,Kazuma Higashisaka,Yasuo Tsutsumi, JOURNAL OF IMMUNOLOGY, AMER ASSOC IMMUNOLOGISTS, Vol. 192, 2014/05
ナノ白金粒子の薬物相互作用に関する検討, 磯田勝広,油科香里,赤浦広紀,西村哲治,手塚雅勝,吉岡靖雄,堤康央,石田功, 日本薬学会年会要旨集(CD-ROM), Vol. 134th, 2014
The effect of lactational exposure to silver nanoparticles on emotional functions of infants, MORISHITA Yuki,MIYAKAWA Tsuyoshi,HIGASHISAKA Kazuma,TSUTSUMI Yasuo,YOSHIOKA Yasuo,TAKIMURA Yuya,NOJIRI Nao,TAKAO Keizo,TAKUMA Kazuhiro,AGO Yukio,TSUNODA Shin-ichi,MATSUDA Toshio, Annual Meeting of the Japanese Society of Toxicology, The Japanese Society of Toxicology, Vol. 41, No. 0, p. P-19, 2014
The transitivity of silver nanoparticles to the infant through the milk, TAKIMURA Yuya,MIYAGAWA Tsuyoshi,HIGASHISAKA Kazuma,TSUTSUMI Yasuo,YOSHIOKA Yasuo,MORISHITA Yuki,NOJIRI Nao,TAKAO Keizo,TAKUMA Kazuhiro,AGO Yukio,TSUNODA Shin-ichi,MATSUDA Toshio, Annual Meeting of the Japanese Society of Toxicology, The Japanese Society of Toxicology, Vol. 41, No. 0, p. O-30, 2014
腫瘍血管マーカーRobo4に対する細胞内侵入抗体の抗体薬物複合体としての有用性評価, 向洋平,吉川舞,岡田欣晃,WILLIAM Aird,吉岡靖雄,角田慎一,堤康央,岡田直貴,土井健史,中川晋作, 日本DDS学会学術集会プログラム予稿集, 日本DDS学会, Vol. 29th, p. 155-155, 2013/06/05
非晶質ナノシリカの妊娠期曝露が仔の情動機能へ及ぼす影響探索, 森下裕貴,吉岡靖雄,高雄啓三,吾郷由希夫,佐藤宏祐,野尻奈央,田中智大,田熊一敞,角田慎一,松田敏夫,宮川剛,東阪和馬,堤康央, J Toxicol Sci, Vol. 38, No. Supplement, 2013/06
The effects of oral administration of silica nanoparticles on immunologic response to the food antigen, Kazuki Misato,Yasuo Yoshioka,Miyuki Uji,Asako Udaka,Takahide Mori,Manami Yamaguchi,Toshiro Hirai,Tokuyuki Yoshida,Hiromi Nabeshi,Tomoaki Yoshikawa,Shin-ichi Tsunoda,Kazuma Higashisaka,Yasuo Tsutsumi, JOURNAL OF IMMUNOLOGY, AMER ASSOC IMMUNOLOGISTS, Vol. 190, 2013/05
The size effects of amorphous silica nanoparticles on atopic dermatitis-like skin lesion, Hideki Takahashi,Yasuo Yoshioka,Toshiro Hirai,Ko-ichi Ichihashi,Nobuo Nishijima,Tokuyuki Yoshida,Hiromi Nabeshi,Tomoaki Yoshikawa,Shin-ichi Tsunoda,Kazuma Higashisaka,Yasuo Tsutsumi, JOURNAL OF IMMUNOLOGY, AMER ASSOC IMMUNOLOGISTS, Vol. 190, 2013/05
Detection of Drug-target Proteins on Tumor-derived Exosomes by ELISA Using Anti-CD81 Antibodies, H. Kamada,T. Yamashita,S. Kanasaki,Y. Maeda,M. Inoue,K. Nagano,Y. Abe,Y. Tsutsumi,S. Tsunoda, EUROPEAN JOURNAL OF CANCER, ELSEVIER SCI LTD, Vol. 48, p. S238-S238, 2012/07
Expression of Rho GDP Dissociation Inhibitor Correlates Positively With Lymph Node Metastasis in Colorectal Cancer, K. Nagano,T. Okamura,T. Yamashita,S. Kanasaki,Y. Maeda,M. Inoue,Y. Abe,H. Kamada,Y. Tsutsumi,S. Tsunoda, EUROPEAN JOURNAL OF CANCER, ELSEVIER SCI LTD, Vol. 48, p. S64-S64, 2012/07
認知機能に着目した非晶質ナノシリカの妊娠期曝露による次世代影響評価, 森下裕貴,吉岡靖雄,高雄啓三,吾郷由希夫,佐藤宏祐,野尻奈央,田熊一敞,角田慎一,鍋師裕美,吉川友章,松田敏夫,宮川剛,堤康央, J Toxicol Sci, 日本毒性学会, Vol. 37, No. Supplement 1, p. S224-135, 2012/07
癌ターゲティング療法における腫瘍血管内皮細胞特異的な細胞内侵入抗体の有用性評価, 柳澤有紀,向洋平,吉川舞,岡田欣晃,吉岡靖雄,角田慎一,堤康央,岡田直貴,土井健史,中川晋作, 日本DDS学会学術集会プログラム予稿集, 日本DDS学会, Vol. 28th, p. 161-161, 2012/06/05
Safety assessment of sub-nano platinum-2-Hazards on neonates, Yuki Morishita,Yuki Morishita,Yasuo Yoshioka,Hiroyoshi Satoh,Nao Nojiri,Hiromi Nabeshi,Tomoaki Yoshikawa,Yasuo Tsutsumi, TOXICOLOGY LETTERS, ELSEVIER IRELAND LTD, Vol. 211, p. S198-S199, 2012/06
Safety assessment of sub-nano platinum-1-Hazards on fetus, Yasuo Yoshioka,Yasuo Yoshioka,Hiroyoshi Satoh,Yuki Morishita,Nao Nojiri,Hiromi Nabeshi,Tomoaki Yoshikawa,Yasuo Tsutsumi, TOXICOLOGY LETTERS, ELSEVIER IRELAND LTD, Vol. 211, p. S198-S198, 2012/06
Hazard identification of nanosilica particles using atopic dermatitis model mouse, Toshiro Hirai,Tomoaki Yoshikawa,Tokuyuki Yoshida,Ko-Ichi Ichihashi,Hideki Takahashi,Hiromi Nabeshi,Yasuo Yoshioka,Yasuo Tsutsumi, TOXICOLOGY LETTERS, ELSEVIER IRELAND LTD, Vol. 211, p. S199-S199, 2012/06
Carbone nanonmaterials: efficacy and safety for nanomedicine, Yamashita T,Yamashita K,Nabeshi H,Yoshikawa T,Yoshioka Y,Tsunoda S,Tsutsumi Y, Materials, Vol. 5: 350-363, No. 2, p. 350-363, 2012
Quantifying the biodistribution of nanoparticles, Yasuo Tsutsumi,Yasuo Yoshioka, NATURE NANOTECHNOLOGY, NATURE PUBLISHING GROUP, Vol. 6, No. 12, p. 755-755, 2011/12
急性ホウ酸中毒に対する血液浄化療法の有効性の検討, 桂木慎一,松本直也,山川一馬,姜晋求,吉岡靖雄,鍋師裕美,吉川友章,小倉裕司,鍬方安行,堤康央,嶋津岳士, 中毒研究, (株)へるす出版, Vol. 24, No. 4, p. 353-354, 2011/12
Detection of titanium dioxide particles on frozen tissue sections using synchrotron radiation X-ray fluorescence analysis, Y. Morishita,K. Yamashita,T. Yoshikawa,Y. Terada,H. Nabeshi,Y. Yoshioka,N. Itoh,Y. Tsutsumi, PHARMAZIE, GOVI-VERLAG PHARMAZEUTISCHER VERLAG GMBH, Vol. 66, No. 10, p. 808-809, 2011/10
Detection of titanium dioxide particles on frozen tissue sections using synchrotron radiation X-ray fluorescence analysis, Y. Morishita,K. Yamashita,T. Yoshikawa,Y. Terada,H. Nabeshi,Y. Yoshioka,N. Itoh,Y. Tsutsumi, PHARMAZIE, GOVI-VERLAG PHARMAZEUTISCHER VERLAG GMBH, Vol. 66, No. 10, p. 808-809, 2011/10
Functional Analysis of a Novel Breast Cancer Related Protein, Ephrin Receptor A10, Y. Maeda,K. Nagano,T. Yamashita,S. Kanasaki,M. Inoue,X. Zhao,Y. Abe,H. Kamada,Y. Tsutsumi,S. Tsunoda, EUROPEAN JOURNAL OF CANCER, ELSEVIER SCI LTD, Vol. 47, p. S339-S339, 2011/09
The Relationship Between Oxysterol Binding Protein Like 5 and Calumenin During Lymph Node Metastasis, K. Nagano,T. Yamashita,S. Kanasaki,Y. Maeda,S. Imai,Y. Abe,H. Kameda,S. Nakagawa,Y. Tsutsumi,S. Tsunoda, EUROPEAN JOURNAL OF CANCER, ELSEVIER SCI LTD, Vol. 47, p. S612-S612, 2011/09
Possibility of Ephrin Receptor A10 as a Drug Target in Triple Negative Breast Cancer, S. Kanasaki,K. Nagano,T. Yamashita,Y. Maeda,M. Inoue,X. Zhao,Y. Abe,H. Kamada,Y. Tsutsumi,S. Tsunoda, EUROPEAN JOURNAL OF CANCER, ELSEVIER SCI LTD, Vol. 47, p. S339-S339, 2011/09
VEGFR2に対する細胞内侵入抗体は優れた抗癌剤送達キャリアである(Cell-internalizing monoclonal antibody against VEGFR2 is a potent anti-cancer agent carrier), 吉川舞,向洋平,角田慎一,堤康央,吉岡靖雄,岡田直貴,中川晋作, 日本癌学会総会記事, 日本癌学会, Vol. 70回, p. 441-441, 2011/09
Size-dependent immune-modulating effect of amorphous nanosilica particles, T. Hirai,T. Yoshikawa,H. Nabeshi,T. Yoshida,S. Tochigi,M. Uji,K. Ichihashi,T. Akase,T. Yamashita,K. Yamashita,K. Nagano,Y. Abe,H. Kamada,S. Tsunoda,Y. Yoshioka,N. Itoh,Y. Tsutsumi, PHARMAZIE, GOVI-VERLAG PHARMAZEUTISCHER VERLAG GMBH, Vol. 66, No. 9, p. 727-728, 2011/09
Hepatotoxicity of silica nanoparticles with a diameter of 100 nm, T. Hasezaki,K. Isoda,M. Kondoh,Y. Tsutsumi,K. Yagi, PHARMAZIE, GOVI-VERLAG PHARMAZEUTISCHER VERLAG GMBH, Vol. 66, No. 9, p. 698-703, 2011/09
Size-dependent immune-modulating effect of amorphous nanosilica particles, T. Hirai,T. Yoshikawa,H. Nabeshi,T. Yoshida,S. Tochigi,M. Uji,K. Ichihashi,T. Akase,T. Yamashita,K. Yamashita,K. Nagano,Y. Abe,H. Kamada,S. Tsunoda,Y. Yoshioka,N. Itoh,Y. Tsutsumi, PHARMAZIE, GOVI-VERLAG PHARMAZEUTISCHER VERLAG GMBH, Vol. 66, No. 9, p. 727-728, 2011/09
Size-dependent immune-modulating effect of amorphous nanosilica particles, T. Hirai,T. Yoshikawa,H. Nabeshi,T. Yoshida,S. Tochigi,M. Uji,K. Ichihashi,T. Akase,T. Yamashita,K. Yamashita,K. Nagano,Y. Abe,H. Kamada,S. Tsunoda,Y. Yoshioka,N. Itoh,Y. Tsutsumi, PHARMAZIE, GOVI-VERLAG PHARMAZEUTISCHER VERLAG GMBH, Vol. 66, No. 9, p. 727-728, 2011/09
Size-dependent immune-modulating effect of amorphous nanosilica particles, T. Hirai,T. Yoshikawa,H. Nabeshi,T. Yoshida,S. Tochigi,M. Uji,K. Ichihashi,T. Akase,T. Yamashita,K. Yamashita,K. Nagano,Y. Abe,H. Kamada,S. Tsunoda,Y. Yoshioka,N. Itoh,Y. Tsutsumi, PHARMAZIE, GOVI-VERLAG PHARMAZEUTISCHER VERLAG GMBH, Vol. 66, No. 9, p. 727-728, 2011/09
Hepatotoxicity of silica nanoparticles with a diameter of 100 nm, T. Hasezaki,K. Isoda,M. Kondoh,Y. Tsutsumi,K. Yagi, PHARMAZIE, GOVI-VERLAG PHARMAZEUTISCHER VERLAG GMBH, Vol. 66, No. 9, p. 698-703, 2011/09
Effect of surface properties of nanosilica on their in vitro safety, M. Uji,T. Yoshikawa,T. Yoshida,T. Hirai,H. Nabeshi,Y. Yoshioka,N. Itoh,Y. Tsutsumi, TOXICOLOGY LETTERS, ELSEVIER IRELAND LTD, Vol. 205, p. S289-S289, 2011/08
In vitro evaluation of the embryotoxic potency of amorphous nanosilica, T. Ogura,Y. Yoshioka,K. Yamashita,K. Kawabata,H. Mizuguchi,T. Yoshikawa,N. Itoh,Y. Tsutsumi, TOXICOLOGY LETTERS, ELSEVIER IRELAND LTD, Vol. 205, p. S251-S251, 2011/08
Development of biomarkers for ensuring safety of nanomaterials, K. Higashisaka,Y. Yoshioka,K. Yamashita,Y. Morishita,H. Nabeshi,S. Tsunoda,N. Itoh,Y. Tsutsumi, TOXICOLOGY LETTERS, ELSEVIER IRELAND LTD, Vol. 205, p. S64-S64, 2011/08
The safety assessment of amorphous nanosilica following dermal exposure, T. Hirai,T. Yoshikawa,T. Yoshida,M. Uji,H. Nabeshi,Y. Yoshioka,N. Itoh,Y. Tsutsumi, TOXICOLOGY LETTERS, ELSEVIER IRELAND LTD, Vol. 205, p. S283-S283, 2011/08
Systemic distribution of amorphous nanosilica following topical application, Y. Yoshioka,M. Uji,T. Yoshida,T. Hirai,H. Nabeshi,S. Tsunoda,N. Itoh,Y. Tsutsumi, TOXICOLOGY LETTERS, ELSEVIER IRELAND LTD, Vol. 205, p. S291-S291, 2011/08
Fine tuning of receptor-selectivity for tumor necrosis factor-alpha using a phage display system with one-step competitive panning, Yasuhiro Abe,Tomoaki Yoshikawa,Masaki Inoue,Tetsuya Nomura,Takeshi Furuya,Takuya Yamashita,Kazuya Nagano,Hiromi Nabeshi,Yasuo Yoshioka,Yohei Mukai,Shinsaku Nakagawa,Haruhiko Kamada,Yasuo Tsutsumi,Shin-ichi Tsunoda, BIOMATERIALS, ELSEVIER SCI LTD, Vol. 32, No. 23, p. 5498-5504, 2011/08
Fine tuning of receptor-selectivity for tumor necrosis factor-alpha using a phage display system with one-step competitive panning, Yasuhiro Abe,Tomoaki Yoshikawa,Masaki Inoue,Tetsuya Nomura,Takeshi Furuya,Takuya Yamashita,Kazuya Nagano,Hiromi Nabeshi,Yasuo Yoshioka,Yohei Mukai,Shinsaku Nakagawa,Haruhiko Kamada,Yasuo Tsutsumi,Shin-ichi Tsunoda, BIOMATERIALS, ELSEVIER SCI LTD, Vol. 32, No. 23, p. 5498-5504, 2011/08
Systemic distribution of amorphous nanosilica following topical application, Y. Yoshioka,M. Uji,T. Yoshida,T. Hirai,H. Nabeshi,S. Tsunoda,N. Itoh,Y. Tsutsumi, TOXICOLOGY LETTERS, ELSEVIER IRELAND LTD, Vol. 205, p. S291-S291, 2011/08
Fine tuning of receptor-selectivity for tumor necrosis factor-alpha using a phage display system with one-step competitive panning, Yasuhiro Abe,Tomoaki Yoshikawa,Masaki Inoue,Tetsuya Nomura,Takeshi Furuya,Takuya Yamashita,Kazuya Nagano,Hiromi Nabeshi,Yasuo Yoshioka,Yohei Mukai,Shinsaku Nakagawa,Haruhiko Kamada,Yasuo Tsutsumi,Shin-ichi Tsunoda, BIOMATERIALS, ELSEVIER SCI LTD, Vol. 32, No. 23, p. 5498-5504, 2011/08
Fine tuning of receptor-selectivity for tumor necrosis factor-alpha using a phage display system with one-step competitive panning, Yasuhiro Abe,Tomoaki Yoshikawa,Masaki Inoue,Tetsuya Nomura,Takeshi Furuya,Takuya Yamashita,Kazuya Nagano,Hiromi Nabeshi,Yasuo Yoshioka,Yohei Mukai,Shinsaku Nakagawa,Haruhiko Kamada,Yasuo Tsutsumi,Shin-ichi Tsunoda, BIOMATERIALS, ELSEVIER SCI LTD, Vol. 32, No. 23, p. 5498-5504, 2011/08
Creation of TNFR1-selective mutant TNF with antagonistic activity, H. Kamada,Y. Abe,K. Nagano,Y. Tsutsumi,S.-I. Tsunoda, JOURNAL OF THROMBOSIS AND HAEMOSTASIS, WILEY-BLACKWELL, Vol. 9, p. 248-248, 2011/07
Effect of amorphous silica nanoparticles on in vitro RANKL-induced osteoclast differentiation in murine macrophages, Hiromi Nabeshi,Tomoaki Yoshikawa,Takanori Akase,Tokuyuki Yoshida,Saeko Tochigi,Toshiro Hirai,Miyuki Uji,Ko-ichi Ichihashi,Takuya Yamashita,Kazuma Higashisaka,Yuki Morishita,Kazuya Nagano,Yasuhiro Abe,Haruhiko Kamada,Shin-ichi Tsunoda,Norio Itoh,Yasuo Yoshioka,Yasuo Tsutsumi, NANOSCALE RESEARCH LETTERS, SPRINGER, Vol. 6, 2011/07
Effect of amorphous silica nanoparticles on in vitro RANKL-induced osteoclast differentiation in murine macrophages, Hiromi Nabeshi,Tomoaki Yoshikawa,Takanori Akase,Tokuyuki Yoshida,Saeko Tochigi,Toshiro Hirai,Miyuki Uji,Ko-ichi Ichihashi,Takuya Yamashita,Kazuma Higashisaka,Yuki Morishita,Kazuya Nagano,Yasuhiro Abe,Haruhiko Kamada,Shin-ichi Tsunoda,Norio Itoh,Yasuo Yoshioka,Yasuo Tsutsumi, NANOSCALE RESEARCH LETTERS, SPRINGER, Vol. 6, 2011/07
標的分子特異的な細胞内薬物送達を目指した細胞内侵入抗体の基礎的特性評価, 吉川舞,向洋平,堤康央,角田慎一,吉岡靖雄,岡田直貴,中川晋作, 日本薬剤学会年会講演要旨集, (公社)日本薬剤学会, Vol. 26th, p. 102-102, 2011/05/01
Silica and titanium dioxide nanoparticles cause pregnancy complications in mice, Kohei Yamashita,Yasuo Yoshioka,Kazuma Higashisaka,Kazuya Mimura,Yuki Morishita,Masatoshi Nozaki,Tokuyuki Yoshida,Toshinobu Ogura,Hiromi Nabeshi,Kazuya Nagano,Yasuhiro Abe,Haruhiko Kamada,Youko Monobe,Takayoshi Imazawa,Hisae Aoshima,Kiyoshi Shishido,Yuichi Kawai,Tadanori Mayumi,Shin-ichi Tsunoda,Norio Itoh,Tomoaki Yoshikawa,Itaru Yanagihara,Shigeru Saito,Yasuo Tsutsumi, NATURE NANOTECHNOLOGY, NATURE PUBLISHING GROUP, Vol. 6, No. 5, p. 321-328, 2011/05
Modifying the antigen-immunization schedule improves the variety of monoclonal antibodies obtained from immune-phage antibody libraries against HIV-1 Nef and Vif, Mai Yoshikawa,Yohei Mukai,Shin-ichi Tsunoda,Yasuo Tsutsumi,Yasuo Yoshioka,Naoki Okada,Shinsaku Nakagawa, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, SOC BIOSCIENCE BIOENGINEERING JAPAN, Vol. 111, No. 5, p. 597-599, 2011/05
Effect of surface charge on nano-sized silica particles-induced liver injury, K. Isoda,T. Hasezaki,M. Kondoh,Y. Tsutsumi,Kiyohito Yagi, Pharmazie, Vol. 66, No. 4, p. 278-281, 2011/05
Development of a novel DDS for site-specific PEGylated proteins, Yasuo Yoshioka,Shin-ichi Tsunoda,Yasuo Tsutsumi, CHEMISTRY CENTRAL JOURNAL, BIOMED CENTRAL LTD, Vol. 5, 2011/05
The effect of surface modification of amorphous silica particles on NLRP3 inflammasome mediated IL-1β production, Vol. 62, No. 3, p. 228-232, 2011/05
Modifying the antigen-immunization schedule improves the variety of monoclonal antibodies obtained from immune-phage antibody libraries against HIV-1 Nef and Vif, Mai Yoshikawa,Yohei Mukai,Shin-ichi Tsunoda,Yasuo Tsutsumi,Yasuo Yoshioka,Naoki Okada,Shinsaku Nakagawa, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, SOC BIOSCIENCE BIOENGINEERING JAPAN, Vol. 111, No. 5, p. 597-599, 2011/05
Silica and titanium dioxide nanoparticles cause pregnancy complications in mice, Kohei Yamashita,Yasuo Yoshioka,Kazuma Higashisaka,Kazuya Mimura,Yuki Morishita,Masatoshi Nozaki,Tokuyuki Yoshida,Toshinobu Ogura,Hiromi Nabeshi,Kazuya Nagano,Yasuhiro Abe,Haruhiko Kamada,Youko Monobe,Takayoshi Imazawa,Hisae Aoshima,Kiyoshi Shishido,Yuichi Kawai,Tadanori Mayumi,Shin-ichi Tsunoda,Norio Itoh,Tomoaki Yoshikawa,Itaru Yanagihara,Shigeru Saito,Yasuo Tsutsumi, NATURE NANOTECHNOLOGY, NATURE PUBLISHING GROUP, Vol. 6, No. 5, p. 321-328, 2011/05
Development of a novel DDS for site-specific PEGylated proteins, Yasuo Yoshioka,Shin-ichi Tsunoda,Yasuo Tsutsumi, CHEMISTRY CENTRAL JOURNAL, BIOMED CENTRAL LTD, Vol. 5, 2011/05
Effect of 70-nm silica particles on the toxicity of acetaminophen, tetracycline, trazodone, and 5-aminosalicylic acid in mice, X. Li,M. Kondoh,A. Watari,T. Hasezaki,K. Isoda,Y. Tsutsumi,K. Yagi, PHARMAZIE, GOVI-VERLAG PHARMAZEUTISCHER VERLAG GMBH, Vol. 66, No. 4, p. 282-286, 2011/04
Effect of surface charge on nano-sized silica particles-induced liver injury, K. Isoda,T. Hasezaki,M. Kondoh,Y. Tsutsumi,K. Yagi, PHARMAZIE, GOVI-VERLAG PHARMAZEUTISCHER VERLAG GMBH, Vol. 66, No. 4, p. 278-281, 2011/04
Effect of 70-nm silica particles on the toxicity of acetaminophen, tetracycline, trazodone, and 5-aminosalicylic acid in mice, X. Li,M. Kondoh,A. Watari,T. Hasezaki,K. Isoda,Y. Tsutsumi,K. Yagi, PHARMAZIE, GOVI-VERLAG PHARMAZEUTISCHER VERLAG GMBH, Vol. 66, No. 4, p. 282-286, 2011/04
抗体プロテオミクス技術による肺がんリンパ節転移関連分子の同定と機能解析, 長野一也,今井直,山下琢矢,渡邊貴信,金崎聡一郎,前田祐香,鍋師裕美,吉川友章,吉岡靖雄,井上雅己,趙秀麗,阿部康弘,鎌田春彦,中川晋作,堤康央,角田慎一, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 131st, No. 4, p. 294-294, 2011/03/05
Recent Topics of NanoTox Studies for Their Safety Foreword, Yasuo Tsutsumi,Yasuo Yoshioka, YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, PHARMACEUTICAL SOC JAPAN, Vol. 131, No. 2, p. 193-194, 2011/02
Limited expression of reticulocalbin-1 in lymphatic endothelial cells in lung tumor but not in normal lung, Yasunobu Yoshida,Takuya Yamashita,Kazuya Nagano,Sunao Imai,Hiromi Nabeshi,Tomoaki Yoshikawa,Yasuo Yoshioka,Yasuhiro Abe,Haruhiko Kamada,Yasuo Tsutsumi,Shin-ichi Tsunoda, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC ELSEVIER SCIENCE, Vol. 405, No. 4, p. 610-614, 2011/02
Recent topics of nanotox studies for their safety, Yasuo Tsutsumi,Yasuo Yoshioka, Yakugaku Zasshi, Vol. 131, No. 2, p. 193-194, 2011/02
Limited expression of reticulocalbin-1 in lymphatic endothelial cells in lung tumor but not in normal lung, Yasunobu Yoshida,Takuya Yamashita,Kazuya Nagano,Sunao Imai,Hiromi Nabeshi,Tomoaki Yoshikawa,Yasuo Yoshioka,Yasuhiro Abe,Haruhiko Kamada,Yasuo Tsutsumi,Shin-ichi Tsunoda, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC ELSEVIER SCIENCE, Vol. 405, No. 4, p. 610-614, 2011/02
Solution of the structure of the TNF-TNFR2 complex, Yohei Mukai,Teruya Nakamura,Mai Yoshikawa,Yasuo Yoshioka,Shin-ichi Tsunoda,Shinsaku Nakagawa,Yuriko Yamagata,Yasuo Tsutsumi, ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES, INT UNION CRYSTALLOGRAPHY, Vol. 67, p. C308-C308, 2011
To the Editor, Yasuo Tsutsumi,Yasuo Yoshioka, Nature Nanotechnology, Nature Publishing Group, Vol. 6, No. 12, 2011
Safety evaluation study of nanomaterials aimed at promoting their acceptance by society, Hiromi Nabeshi,Tomoaki Yoshikawa,Yasuo Yoshioka,Yasuo Tsutsumi, Genes and Environment, Vol. 33, No. 1, p. 21-26, 2011
MUTANT TNF ELICITS MUCOSAL AND SYSTEMIC IMMUNITY AGAINST HIV-1 AND INFLUENZA VIRUS, Yasuhiro Abe,Hiroyuki Kayamuro,Yasuo Yoshioka,Kazuhumi Katayama,Haruhiko Kamada,Tetsuya Nomura,Takachika Hiroi,Shin-nichi Tsunoda,Yasuo Tsutsumi, ADVANCES IN TNF FAMILY RESEARCH, SPRINGER-VERLAG BERLIN, Vol. 691, p. 801-802, 2011
DEVELOPMENT OF A NOVEL METHOD USING PHAGE DISPLAY, GENE SHUFFLING AND IMPROVED RECEPTOR SELECTIVITY TO PRODUCE MUTANT TNFS, Tetsuya Nomura,Yasuhiro Abe,Yasuo Yoshioka,Hiroyuki Kayamuro,Hiroko Shibata,Yohei Mukai,Shin-ichi Tsunoda,Yasuo Tsutsumi, ADVANCES IN TNF FAMILY RESEARCH, SPRINGER-VERLAG BERLIN, Vol. 691, p. 802-802, 2011
Identification of New Candidates as Mucosal Vaccine Adjuvant in TNF Family Cytokines, Kayamuro H,Yoshioka Y,Abe Y,Katayama K,Arita S,Nomura T,Yoshikawa T,Itoh N,Kamada H,Tsunoda S,Tsutsumi Y, Adv Exp Med Biol, Vol. 691: 299-304, 2011
Postnatal effects of prenatal treatment of amorphous nanosilica, MORISHITA Yuki,ABE Yasuhiro,KAMADA Haruhiko,TSUNIDA Shin-ichi,NABESHI Hiromi,ITOH Norio,YOSHIKAWA Tomoaki,MIYAKAWA Tsuyoshi,TSUTSUMI Yasuo,YOSHIOKA Yasuo,TAKAO Keizo,YAMASHITA Kohei,HIGASHISAKA Kazuma,FUJIMURA Maho,PAN Huiyan,OGURA Toshinobu,NAGANO Kazuya, Annual Meeting of the Japanese Society of Toxicology, The Japanese Society of Toxicology, Vol. 38, No. 0, p. 20071-20071, 2011
Development of an antibody proteomics system using a phage antibody library for efficient screening of biomarker proteins, Sunao Imai,Kazuya Nagano,Yasunobu Yoshida,Takayuki Okamura,Takuya Yamashita,Yasuhiro Abe,Tomoaki Yoshikawa,Yasuo Yoshioka,Haruhiko Kamada,Yohei Mukai,Shinsaku Nakagawa,Yasuo Tsutsumi,Shin-ichi Tsunoda, BIOMATERIALS, ELSEVIER SCI LTD, Vol. 32, No. 1, p. 162-169, 2011/01
Acute phase proteins as biomarkers for predicting the exposure and toxicity of nanomaterials, Kazuma Higashisaka,Yasuo Yoshioka,Kohei Yamashita,Yuki Morishita,Maho Fujimura,Hiromi Nabeshi,Kazuya Nagano,Yasuhiro Abe,Haruhiko Kamada,Shin-ichi Tsunoda,Tomoaki Yoshikawa,Norio Itoh,Yasuo Tsutsumi, BIOMATERIALS, ELSEVIER SCI LTD, Vol. 32, No. 1, p. 3-9, 2011/01
Development of an antibody proteomics system using a phage antibody library for efficient screening of biomarker proteins, Sunao Imai,Kazuya Nagano,Yasunobu Yoshida,Takayuki Okamura,Takuya Yamashita,Yasuhiro Abe,Tomoaki Yoshikawa,Yasuo Yoshioka,Haruhiko Kamada,Yohei Mukai,Shinsaku Nakagawa,Yasuo Tsutsumi,Shin-ichi Tsunoda, BIOMATERIALS, ELSEVIER SCI LTD, Vol. 32, No. 1, p. 162-169, 2011/01
ANTI-INFLAMMATORY EFFECTS OF A NOVEL TNFR1-SELECTIVE ANTAGONISTIC TNF MUTANT ON ESTABLISHED MURINE COLLAGEN-INDUCED ARTHRITIS, Shin-ichi Tsunoda,Yasuhiro Abe,Tetsuya Nomura,Hiroko Shibata,Yasuo Yoshioka,Haruhiko Kamada,Yasuo Tsutsumi, ADVANCES IN TNF FAMILY RESEARCH, SPRINGER-VERLAG BERLIN, Vol. 691, p. 803-803, 2011
Therapeutic effect of PEGylated TNFR1-selective antagonistic mutant TNF in experimental autoimmune encephalomyelitis mice, Tetsuya Nomura,Yasuhiro Abe,Haruhiko Kamada,Hiroko Shibata,Hiroyuki Kayamuro,Masaki Inoue,Tomoyuki Kawara,Shuhei Arita,Takeshi Furuya,Takuya Yamashita,Kazuya Nagano,Tomoaki Yoshikawa,Yasuo Yoshioka,Yohei Mukai,Shinsaku Nakagawa,Madoka Taniai,Tsunetaka Ohta,Satoshi Serada,Tetsuji Naka,Shin-ichi Tsunoda,Yasuo Tsutsumi, JOURNAL OF CONTROLLED RELEASE, ELSEVIER, Vol. 149, No. 1, p. 8-14, 2011/01
Promotion of allergic immune responses by intranasally-administrated nanosilica particles in mice, Tokuyuki Yoshida,Yasuo Yoshioka,Maho Fujimura,Kohei Yamashita,Kazuma Higashisaka,Yuki Morishita,Hiroyuki Kayamuro,Hiromi Nabeshi,Kazuya Nagano,Yasuhiro Abe,Haruhiko Kamada,Shin-ichi Tsunoda,Norio Itoh,Tomoaki Yoshikawa,Yasuo Tsutsumi, NANOSCALE RESEARCH LETTERS, SPRINGER, Vol. 6, 2011
Safety evaluation study of nanomaterials aimed at the promotion of the social reception., Gene. Environ, 2011
PEG化による腫瘍壊死因子TNF-αの体内動態の制御と抗腫瘍効果増強, 遺伝子医学MOOK別冊, 2011
Amorphous nanosilica induce endocytosis-dependent ROS generation and DNA damage in human keratinocytes, Hiromi Nabeshi,Tomoaki Yoshikawa,Keigo Matsuyama,Yasutaro Nakazato,Saeko Tochigi,Sayuri Kondoh,Toshiro Hirai,Takanori Akase,Kazuya Nagano,Yasuhiro Abe,Yasuo Yoshioka,Haruhiko Kamada,Norio Itoh,Shin-ichi Tsunoda,Yasuo Tsutsumi, PARTICLE AND FIBRE TOXICOLOGY, BIOMED CENTRAL LTD, Vol. 8, 2011/01
Effect of surface properties of silica nanoparticles on their cytotoxicity and cellular distribution in murine macrophages, Hiromi Nabeshi,Tomoaki Yoshikawa,Akihiro Arimori,Tokuyuki Yoshida,Saeko Tochigi,Toshiro Hirai,Takanori Akase,Kazuya Nagano,Yasuhiro Abe,Haruhiko Kamada,Shin-ichi Tsunoda,Norio Itoh,Yasuo Yoshioka,Yasuo Tsutsumi, NANOSCALE RESEARCH LETTERS, SPRINGER, Vol. 6, 2011
食品分野におけるナノテクノロジーの安全性, 食品衛生研究, 2011
アジュバントとしてのサイトカインおよびその機能性変異体, 『アジュバント開発研究の新展開』, 2011
ドラッグデリバリーシステム(DDS)技術の開発, 新しい薬学事典, 2011
PEG化蛋白質の創製, バイオ医薬品の処方設計と開発技術, 2011
Development of an antibody proteomics system using a phage antibody library for efficient screening of biomarker proteins, Sunao Imai,Kazuya Nagano,Yasunobu Yoshida,Takayuki Okamura,Takuya Yamashita,Yasuhiro Abe,Tomoaki Yoshikawa,Yasuo Yoshioka,Haruhiko Kamada,Yohei Mukai,Shinsaku Nakagawa,Yasuo Tsutsumi,Shin-ichi Tsunoda, BIOMATERIALS, ELSEVIER SCI LTD, Vol. 32, No. 1, p. 162-169, 2011/01
ANTI-INFLAMMATORY EFFECTS OF A NOVEL TNFR1-SELECTIVE ANTAGONISTIC TNF MUTANT ON ESTABLISHED MURINE COLLAGEN-INDUCED ARTHRITIS, Shin-ichi Tsunoda,Yasuhiro Abe,Tetsuya Nomura,Hiroko Shibata,Yasuo Yoshioka,Haruhiko Kamada,Yasuo Tsutsumi, ADVANCES IN TNF FAMILY RESEARCH, SPRINGER-VERLAG BERLIN, Vol. 691, p. 803-803, 2011
Development of an antibody proteomics system using a phage antibody library for efficient screening of biomarker proteins, Sunao Imai,Kazuya Nagano,Yasunobu Yoshida,Takayuki Okamura,Takuya Yamashita,Yasuhiro Abe,Tomoaki Yoshikawa,Yasuo Yoshioka,Haruhiko Kamada,Yohei Mukai,Shinsaku Nakagawa,Yasuo Tsutsumi,Shin-ichi Tsunoda, BIOMATERIALS, ELSEVIER SCI LTD, Vol. 32, No. 1, p. 162-169, 2011/01
Acute phase proteins as biomarkers for predicting the exposure and toxicity of nanomaterials, Kazuma Higashisaka,Yasuo Yoshioka,Kohei Yamashita,Yuki Morishita,Maho Fujimura,Hiromi Nabeshi,Kazuya Nagano,Yasuhiro Abe,Haruhiko Kamada,Shin-ichi Tsunoda,Tomoaki Yoshikawa,Norio Itoh,Yasuo Tsutsumi, BIOMATERIALS, ELSEVIER SCI LTD, Vol. 32, No. 1, p. 3-9, 2011/01
Therapeutic effect of PEGylated TNFR1-selective antagonistic mutant TNF in experimental autoimmune encephalomyelitis mice, Tetsuya Nomura,Yasuhiro Abe,Haruhiko Kamada,Hiroko Shibata,Hiroyuki Kayamuro,Masaki Inoue,Tomoyuki Kawara,Shuhei Arita,Takeshi Furuya,Takuya Yamashita,Kazuya Nagano,Tomoaki Yoshikawa,Yasuo Yoshioka,Yohei Mukai,Shinsaku Nakagawa,Madoka Taniai,Tsunetaka Ohta,Satoshi Serada,Tetsuji Naka,Shin-ichi Tsunoda,Yasuo Tsutsumi, JOURNAL OF CONTROLLED RELEASE, ELSEVIER, Vol. 149, No. 1, p. 8-14, 2011/01
Amorphous nanosilica induce endocytosis-dependent ROS generation and DNA damage in human keratinocytes, Hiromi Nabeshi,Tomoaki Yoshikawa,Keigo Matsuyama,Yasutaro Nakazato,Saeko Tochigi,Sayuri Kondoh,Toshiro Hirai,Takanori Akase,Kazuya Nagano,Yasuhiro Abe,Yasuo Yoshioka,Haruhiko Kamada,Norio Itoh,Shin-ichi Tsunoda,Yasuo Tsutsumi, PARTICLE AND FIBRE TOXICOLOGY, BIOMED CENTRAL LTD, Vol. 8, 2011/01
Promotion of allergic immune responses by intranasally-administrated nanosilica particles in mice, Tokuyuki Yoshida,Yasuo Yoshioka,Maho Fujimura,Kohei Yamashita,Kazuma Higashisaka,Yuki Morishita,Hiroyuki Kayamuro,Hiromi Nabeshi,Kazuya Nagano,Yasuhiro Abe,Haruhiko Kamada,Shin-ichi Tsunoda,Norio Itoh,Tomoaki Yoshikawa,Yasuo Tsutsumi, NANOSCALE RESEARCH LETTERS, SPRINGER, Vol. 6, 2011
Effect of surface properties of silica nanoparticles on their cytotoxicity and cellular distribution in murine macrophages, Hiromi Nabeshi,Tomoaki Yoshikawa,Akihiro Arimori,Tokuyuki Yoshida,Saeko Tochigi,Toshiro Hirai,Takanori Akase,Kazuya Nagano,Yasuhiro Abe,Haruhiko Kamada,Shin-ichi Tsunoda,Norio Itoh,Yasuo Yoshioka,Yasuo Tsutsumi, NANOSCALE RESEARCH LETTERS, SPRINGER, Vol. 6, 2011
Safety evaluation study of nanomaterials aimed at the promotion of the social reception., Gene. Environ, 2011
Potential adjuvant effect of intranasal urban aerosols in mice through induction of dendritic cell maturation, Tokuyuki Yoshida,Yasuo Yoshioka,Maho Fujimura,Kohei Yamashita,Kazuma Higashisaka,Ryosuke Nakanishi,Yuki Morishita,Hiroyuki Kayamuro,Hiromi Nabeshi,Kazuya Nagano,Yasuhiro Abe,Haruhiko Kamada,Shinichi Tsunoda,Tomoaki Yoshikawa,Norio Itoh,Yasuo Tsutsumi, TOXICOLOGY LETTERS, ELSEVIER IRELAND LTD, Vol. 199, No. 3, p. 383-388, 2010/12
Interleukin-1 Family Cytokines as Mucosal Vaccine Adjuvants for Induction of Protective Immunity against Influenza Virus, Hiroyuki Kayamuro,Yasuo Yoshioka,Yasuhiro Abe,Shuhei Arita,Kazufumi Katayama,Tetsuya Nomura,Tomoaki Yoshikawa,Ritsuko Kubota-Koketsu,Kazuyoshi Ikuta,Shigefumi Okamoto,Yasuko Mori,Jun Kunisawa,Hiroshi Kiyono,Norio Itoh,Kazuya Nagano,Haruhiko Kamada,Yasuo Tsutsumi,Shin-Ichi Tsunoda, JOURNAL OF VIROLOGY, AMER SOC MICROBIOLOGY, Vol. 84, No. 24, p. 12703-12712, 2010/12
Potential adjuvant effect of intranasal urban aerosols in mice through induction of dendritic cell maturation, Tokuyuki Yoshida,Yasuo Yoshioka,Maho Fujimura,Kohei Yamashita,Kazuma Higashisaka,Ryosuke Nakanishi,Yuki Morishita,Hiroyuki Kayamuro,Hiromi Nabeshi,Kazuya Nagano,Yasuhiro Abe,Haruhiko Kamada,Shinichi Tsunoda,Tomoaki Yoshikawa,Norio Itoh,Yasuo Tsutsumi, TOXICOLOGY LETTERS, ELSEVIER IRELAND LTD, Vol. 199, No. 3, p. 383-388, 2010/12
Interleukin-1 Family Cytokines as Mucosal Vaccine Adjuvants for Induction of Protective Immunity against Influenza Virus, Hiroyuki Kayamuro,Yasuo Yoshioka,Yasuhiro Abe,Shuhei Arita,Kazufumi Katayama,Tetsuya Nomura,Tomoaki Yoshikawa,Ritsuko Kubota-Koketsu,Kazuyoshi Ikuta,Shigefumi Okamoto,Yasuko Mori,Jun Kunisawa,Hiroshi Kiyono,Norio Itoh,Kazuya Nagano,Haruhiko Kamada,Yasuo Tsutsumi,Shin-Ichi Tsunoda, JOURNAL OF VIROLOGY, AMER SOC MICROBIOLOGY, Vol. 84, No. 24, p. 12703-12712, 2010/12
Solution of the Structure of the TNF-TNFR2 Complex, Yohei Mukai,Teruya Nakamura,Mai Yoshikawa,Yasuo Yoshioka,Shin-ichi Tsunoda,Shinsaku Nakagawa,Yuriko Yamagata,Yasuo Tsutsumi, SCIENCE SIGNALING, AMER ASSOC ADVANCEMENT SCIENCE, Vol. 3, No. 148, 2010/11
Solution of the Structure of the TNF-TNFR2 Complex, Yohei Mukai,Teruya Nakamura,Mai Yoshikawa,Yasuo Yoshioka,Shin-ichi Tsunoda,Shinsaku Nakagawa,Yuriko Yamagata,Yasuo Tsutsumi, SCIENCE SIGNALING, AMER ASSOC ADVANCEMENT SCIENCE, Vol. 3, No. 148, 2010/11
ナノ含有食品の安全性確保および安全なナノ含有食品の開発に向けて:ナノ酸化チタンの形状と免疫系への影響, 吉岡靖雄,森重智弘,吉川友章,長野一也,阿部康弘,鎌田春彦,伊藤徳夫,角田慎一,向洋平,岡田直貴,中川晋作,堤康央, 日本食品衛生学会学術講演会講演要旨集, (公社)日本食品衛生学会, Vol. 100th, p. 91-91, 2010/09/16
The effect of surface modification of amorphous silica particles on NLRP3 inflammasome mediated IL-1 beta production, ROS production and endosomal rupture, Tomohiro Morishige,Yasuo Yoshioka,Hiroshi Inakura,Aya Tanabe,Xinglei Yao,Shogo Narimatsu,Youko Monobe,Takayoshi Imazawa,Shin-ichi Tsunoda,Yasuo Tsutsumi,Yohei Mukai,Naoki Okada,Shinsaku Nakagawa, BIOMATERIALS, ELSEVIER SCI LTD, Vol. 31, No. 26, p. 6833-6842, 2010/09
The effect of surface modification of amorphous silica particles on NLRP3 inflammasome mediated IL-1 beta production, ROS production and endosomal rupture, Tomohiro Morishige,Yasuo Yoshioka,Hiroshi Inakura,Aya Tanabe,Xinglei Yao,Shogo Narimatsu,Youko Monobe,Takayoshi Imazawa,Shin-ichi Tsunoda,Yasuo Tsutsumi,Yohei Mukai,Naoki Okada,Shinsaku Nakagawa, BIOMATERIALS, ELSEVIER SCI LTD, Vol. 31, No. 26, p. 6833-6842, 2010/09
安全なナノマテリアルの開発に向けた非晶質ナノシリカの粒子特性と起炎性の連関評価, 吉岡靖雄,森重智弘,稲倉裕,吉川友章,角田慎一,向洋平,岡田直貴,中川晋作,堤康央, 日本免疫毒性学会講演抄録集, Vol. 17th(CD-ROM), 2010/08
Cytotoxicity of amorphous silica particles against macrophage-like THP-1 cells depends on particle-size and surface properties, T. Morishige,Y. Yoshioka,H. Inakura,A. Tanabe,X. Yao,S. Tsunoda,Y. Tsutsumi,Y. Mukai,N. Okada,S. Nakagawa, PHARMAZIE, GOVI-VERLAG PHARMAZEUTISCHER VERLAG GMBH, Vol. 65, No. 8, p. 596-599, 2010/08
Carbon Nanotubes Elicit DNA Damage and Inflammatory Response Relative to Their Size and Shape, Kohei Yamashita,Yasuo Yoshioka,Kazuma Higashisaka,Yuki Morishita,Tokuyuki Yoshida,Maho Fujimura,Hiroyuki Kayamuro,Hiromi Nabeshi,Takuya Yamashita,Kazuya Nagano,Yasuhiro Abe,Haruhiko Kamada,Yuichi Kawai,Tadanori Mayumi,Tomoaki Yoshikawa,Norio Itoh,Shin-ichi Tsunoda,Yasuo Tsutsumi, INFLAMMATION, SPRINGER/PLENUM PUBLISHERS, Vol. 33, No. 4, p. 276-280, 2010/08
Carbon Nanotubes Elicit DNA Damage and Inflammatory Response Relative to Their Size and Shape, Kohei Yamashita,Yasuo Yoshioka,Kazuma Higashisaka,Yuki Morishita,Tokuyuki Yoshida,Maho Fujimura,Hiroyuki Kayamuro,Hiromi Nabeshi,Takuya Yamashita,Kazuya Nagano,Yasuhiro Abe,Haruhiko Kamada,Yuichi Kawai,Tadanori Mayumi,Tomoaki Yoshikawa,Norio Itoh,Shin-ichi Tsunoda,Yasuo Tsutsumi, INFLAMMATION, SPRINGER/PLENUM PUBLISHERS, Vol. 33, No. 4, p. 276-280, 2010/08
Cytotoxicity of amorphous silica particles against macrophage-like THP-1 cells depends on particle-size and surface properties, T. Morishige,Y. Yoshioka,H. Inakura,A. Tanabe,X. Yao,S. Tsunoda,Y. Tsutsumi,Y. Mukai,N. Okada,S. Nakagawa, PHARMAZIE, GOVI-VERLAG PHARMAZEUTISCHER VERLAG GMBH, Vol. 65, No. 8, p. 596-599, 2010/08
Identification and evaluation of novel breast cancer related biomarker proteins by antibody proteomics technology, K. Nagano,T. Yamashita,S. Imai,Y. Abe,T. Yoshikawa,Y. Yoshioka,H. Kamada,Y. Tsutsumi,S. Tsunoda, EJC SUPPLEMENTS, PERGAMON-ELSEVIER SCIENCE LTD, Vol. 8, No. 5, p. 53-53, 2010/06
Identification and evaluation of tumour lymphatic endothelial cell-specific proteins by antibody proteomics technology, S. Tsunoda,K. Nagano,T. Yamashita,S. Imai,Y. Abe,T. Yoshikawa,Y. Yoshioka,H. Kamada,Y. Tsutsumi, EJC SUPPLEMENTS, PERGAMON-ELSEVIER SCIENCE LTD, Vol. 8, No. 5, p. 64-65, 2010/06
Immuno‐conjugate製剤における抗体の細胞内侵入活性と抗腫瘍効果の連関解析, 吉川舞,向洋平,堤康央,角田慎一,吉岡靖雄,岡田直貴,中川晋作, Drug Deliv Syst, 日本DDS学会, Vol. 25, No. 3, p. 298-298, 2010/05/28
T細胞受容体の新規ターゲティング分子への適用を目指した検討, 成松翔伍,吉岡靖雄,堤康央,向洋平,岡田直貴,中川晋作, Drug Deliv Syst, 日本DDS学会, Vol. 25, No. 3, p. 290-290, 2010/05/28
線虫C.elegansにおけるナノシリカの生体影響及び遺伝子発現変動解析, 井口綾子,上田清佳,内匠正太,山元涼子,吉赫哲,吉岡靖雄,堤康央,冨永伸明,有薗幸司, The Journal of Toxicological Sciences, (一社)日本毒性学会, Vol. 35, No. Suppl., p. S114-S114, 2010/05
非晶質ナノシリカの粒子特性と自然免疫応答の連関評価とそのメカニズム解析, 吉岡靖雄,森重智弘,角田慎一,向洋平,岡田直貴,堤康央,中川晋作, J Toxicol Sci, 日本毒性学会, Vol. 35, No. Supplement, p. S112-111, 2010/05
Urban Aerosols Induce Pro-inflammatory Cytokine Production in Macrophages and Cause Airway Inflammation in Vivo, Tokuyuki Yoshida,Yasuo Yoshioka,Maho Fujimura,Hiroyuki Kayamuro,Kohei Yamashita,Kazuma Higashisaka,Ryosuke Nakanishi,Yuki Morishita,Hiromi Nabeshi,Takuya Yamashita,Masashi Muroi,Kenichi Tanamoto,Kazuya Nagano,Yasuhiro Abe,Haruhiko Kamada,Yuichi Kawai,Tadanori Mayumi,Norio Itoh,Tomoaki Yoshikawa,Shinichi Tsunoda,Yasuo Tsutsumi, BIOLOGICAL & PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOC JAPAN, Vol. 33, No. 5, p. 780-783, 2010/05
Urban Aerosols Induce Pro-inflammatory Cytokine Production in Macrophages and Cause Airway Inflammation in Vivo, Tokuyuki Yoshida,Yasuo Yoshioka,Maho Fujimura,Hiroyuki Kayamuro,Kohei Yamashita,Kazuma Higashisaka,Ryosuke Nakanishi,Yuki Morishita,Hiromi Nabeshi,Takuya Yamashita,Masashi Muroi,Kenichi Tanamoto,Kazuya Nagano,Yasuhiro Abe,Haruhiko Kamada,Yuichi Kawai,Tadanori Mayumi,Norio Itoh,Tomoaki Yoshikawa,Shinichi Tsunoda,Yasuo Tsutsumi, BIOLOGICAL & PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOC JAPAN, Vol. 33, No. 5, p. 780-783, 2010/05
Immune‐conjugate製剤の開発に適う細胞内侵入抗体の効率的創製法の確立, 吉川舞,向洋平,堤康央,角田慎一,吉岡靖雄,岡田直貴,中川晋作, 薬剤学, (公社)日本薬剤学会, Vol. 70, No. Supplement, p. 104-104, 2010/04/20
T細胞受容体の新規ターゲティング分子への適用を目指した検討, 成松翔伍,吉岡靖雄,堤康央,向洋平,岡田直貴,中川晋作, 薬剤学, (公社)日本薬剤学会, Vol. 70, No. Supplement, p. 140-140, 2010/04/20
多発性硬化症治療薬の開発を目指したレセプター選択的蛋白質性アンタゴニストの創出, 野村鉄也,阿部康弘,鎌田春彦,古屋剛,井上雅己,角田慎一,堤康央,宇都口直樹,丸山一雄, 薬剤学, Vol. 70, No. Supplement, 2010/04/20
Special session presented by the Study Group on Fibrous and Particulate Substances (SGFPS): Invited lecture: The safety scientific assessment of nanomaterials, Japanese journal of hygiene, Vol. 65, No. 2, p. 253-255, 2010/04
From Disease Proteomics to Biomarker Development-Establishment of Antibody Proteomics Technology and Exploration of Cancer-related Biomarkers, Kazuya Nagano,Sunao Imai,Shinsaku Nakagawa,Shin-ichi Tsunoda,Yasuo Tsutsumi, YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, PHARMACEUTICAL SOC JAPAN, Vol. 130, No. 4, p. 487-492, 2010/04
Development of Anti-tumor Blood Vessel Antibodies by Phage Display Method, Takuya Yamashita,Naoki Utoguchi,Ryo Suzuki,Kazuya Nagano,Shin-ichi Tsunoda,Yasuo Tsutsumi,Kazuo Maruyama, YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, PHARMACEUTICAL SOC JAPAN, Vol. 130, No. 4, p. 479-485, 2010/04
Generation of mouse macrophages expressing membrane-bound TNF variants with selectivity for TNFR1 or TNFR2, Hiroko Shibata,Yasuhiro Abe,Yasuo Yoshioka,Tetsuya Nomura,Masaki Sato,Hiroyuki Kayamuro,Tomoyuki Kawara,Shuhei Arita,Tsuyoshi Furuya,Kazuya Nagano,Tomoaki Yoshikawa,Haruhiko Kamada,Shin-ichi Tsunoda,Yasuo Tsutsumi, CYTOKINE, ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, Vol. 50, No. 1, p. 75-83, 2010/04
Creation of a LIGHT mutant with the capacity to evade the decoy receptor for cancer therapy, Tomohiro Morishige,Yasuo Yoshioka,Hiroshi Inakura,Aya Tanabe,Xinglei Yao,Shin-ichi Tsunoda,Yasuo Tsutsumi,Yohei Mukai,Naoki Okada,Shinsaku Nakagawa, BIOMATERIALS, ELSEVIER SCI LTD, Vol. 31, No. 12, p. 3357-3363, 2010/04
Mutant TNF-alpha, mTNF-K90R, is a novel candidate adjuvant for a mucosal vaccine against HIV, H. Kayamuro,Y. Abe,Y. Yoshioka,K. Katayama,T. Yoshida,K. Yamashita,T. Yoshikawa,Y. Kawai,T. Mayumi,T. Hiroi,N. Itoh,K. Nagano,H. Kamada,S. Tsunoda,Y. Tsutsumi, PHARMAZIE, GOVI-VERLAG PHARMAZEUTISCHER VERLAG GMBH, Vol. 65, No. 4, p. 254-256, 2010/04
Safety Assessment of Nanomaterials Using Toxicokinetics and Toxicoproteome Analysis, Hiromi Nabeshi,Tomoaki Yoshikawa,Takayoshi Imazawa,Shin-ichi Tsunoda,Yasuo Tsutsumi, YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, PHARMACEUTICAL SOC JAPAN, Vol. 130, No. 4, p. 465-470, 2010/04
Generation of mouse macrophages expressing membrane-bound TNF variants with selectivity for TNFR1 or TNFR2, Hiroko Shibata,Yasuhiro Abe,Yasuo Yoshioka,Tetsuya Nomura,Masaki Sato,Hiroyuki Kayamuro,Tomoyuki Kawara,Shuhei Arita,Tsuyoshi Furuya,Kazuya Nagano,Tomoaki Yoshikawa,Haruhiko Kamada,Shin-ichi Tsunoda,Yasuo Tsutsumi, CYTOKINE, ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, Vol. 50, No. 1, p. 75-83, 2010/04
Creation of a LIGHT mutant with the capacity to evade the decoy receptor for cancer therapy, Tomohiro Morishige,Yasuo Yoshioka,Hiroshi Inakura,Aya Tanabe,Xinglei Yao,Shin-ichi Tsunoda,Yasuo Tsutsumi,Yohei Mukai,Naoki Okada,Shinsaku Nakagawa, Biomaterials, Vol. 31, No. 12, p. 3357-3363, 2010/04
Mutant TNF-alpha, mTNF-K90R, is a novel candidate adjuvant for a mucosal vaccine against HIV, H. Kayamuro,Y. Abe,Y. Yoshioka,K. Katayama,T. Yoshida,K. Yamashita,T. Yoshikawa,Y. Kawai,T. Mayumi,T. Hiroi,N. Itoh,K. Nagano,H. Kamada,S. Tsunoda,Y. Tsutsumi, PHARMAZIE, GOVI-VERLAG PHARMAZEUTISCHER VERLAG GMBH, Vol. 65, No. 4, p. 254-256, 2010/04
Development of Anti-tumor Blood Vessel Antibodies by Phage Display Method, Takuya Yamashita,Naoki Utoguchi,Ryo Suzuki,Kazuya Nagano,Shin-ichi Tsunoda,Yasuo Tsutsumi,Kazuo Maruyama, YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, PHARMACEUTICAL SOC JAPAN, Vol. 130, No. 4, p. 479-485, 2010/04
Generation of mouse macrophages expressing membrane-bound TNF variants with selectivity for TNFR1 or TNFR2, Hiroko Shibata,Yasuhiro Abe,Yasuo Yoshioka,Tetsuya Nomura,Masaki Sato,Hiroyuki Kayamuro,Tomoyuki Kawara,Shuhei Arita,Tsuyoshi Furuya,Kazuya Nagano,Tomoaki Yoshikawa,Haruhiko Kamada,Shin-ichi Tsunoda,Yasuo Tsutsumi, CYTOKINE, ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, Vol. 50, No. 1, p. 75-83, 2010/04
Creation of a LIGHT mutant with the capacity to evade the decoy receptor for cancer therapy, Tomohiro Morishige,Yasuo Yoshioka,Hiroshi Inakura,Aya Tanabe,Xinglei Yao,Shin-ichi Tsunoda,Yasuo Tsutsumi,Yohei Mukai,Naoki Okada,Shinsaku Nakagawa, Biomaterials, Vol. 31, No. 12, p. 3357-3363, 2010/04
From Disease Proteomics to Biomarker Development-Establishment of Antibody Proteomics Technology and Exploration of Cancer-related Biomarkers, Kazuya Nagano,Sunao Imai,Shinsaku Nakagawa,Shin-ichi Tsunoda,Yasuo Tsutsumi, YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, PHARMACEUTICAL SOC JAPAN, Vol. 130, No. 4, p. 487-492, 2010/04
Safety Assessment of Nanomaterials Using Toxicokinetics and Toxicoproteome Analysis, Hiromi Nabeshi,Tomoaki Yoshikawa,Takayoshi Imazawa,Shin-ichi Tsunoda,Yasuo Tsutsumi, YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, PHARMACEUTICAL SOC JAPAN, Vol. 130, No. 4, p. 465-470, 2010/04
Generation of mouse macrophages expressing membrane-bound TNF variants with selectivity for TNFR1 or TNFR2, Hiroko Shibata,Yasuhiro Abe,Yasuo Yoshioka,Tetsuya Nomura,Masaki Sato,Hiroyuki Kayamuro,Tomoyuki Kawara,Shuhei Arita,Tsuyoshi Furuya,Kazuya Nagano,Tomoaki Yoshikawa,Haruhiko Kamada,Shin-ichi Tsunoda,Yasuo Tsutsumi, CYTOKINE, ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, Vol. 50, No. 1, p. 75-83, 2010/04
Creation of a LIGHT mutant with the capacity to evade the decoy receptor for cancer therapy, Tomohiro Morishige,Yasuo Yoshioka,Hiroshi Inakura,Aya Tanabe,Xinglei Yao,Shin-ichi Tsunoda,Yasuo Tsutsumi,Yohei Mukai,Naoki Okada,Shinsaku Nakagawa, Biomaterials, Vol. 31, No. 12, p. 3357-3363, 2010/04
新規バイオ医薬の開発を目指した腫瘍組織血管特異抗体の創製, 山下琢矢,宇都口直樹,長野一也,丸山一雄,鎌田春彦,角田慎一,堤康央, 日本薬学会年会要旨集, Vol. 130th, No. 1, 2010/03/05
プロテオミクスによる非アルコール性脂肪性肝疾患(NAFLD/NASH)のバイオマーカー探索, 渡邊貴信,長野一也,山下琢矢,岡村賢孝,金崎聡一郎,阿部康弘,吉川友章,吉岡靖雄,鎌田春彦,伊藤徳夫,小泉桂一,角田慎一,堤康央, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 130年会, No. 4, p. 313-313, 2010/03
Size-dependent cytotoxic effects of amorphous silica nanoparticles on Langerhans cells, H. Nabeshi,T. Yoshikawa,K. Matsuyama,Y. Nakazato,A. Arimori,M. Isobe,S. Tochigi,S. Kondoh,T. Hirai,T. Akase,T. Yamashita,K. Yamashita,T. Yoshida,K. Nagano,Y. Abe,Y. Yoshioka,H. Kamada,T. Imazawa,N. Itoh,S. Tsunoda,Y. Tsutsumi, PHARMAZIE, GOVI-VERLAG PHARMAZEUTISCHER VERLAG GMBH, Vol. 65, No. 3, p. 199-201, 2010/03
Creation of a lysine-deficient LIGHT mutant with the capacity for site-specific PEGylation and low affinity for a decoy receptor, Tomohiro Morishige,Yasuo Yoshioka,Hiroshi Inakura,Aya Tanabe,Xinglei Yao,Shin-ichi Tsunoda,Yasuo Tsutsumi,Yohei Mukai,Naoki Okada,Shinsaku Nakagawa, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC ELSEVIER SCIENCE, Vol. 393, No. 4, p. 888-893, 2010/03
Size-dependent cytotoxic effects of amorphous silica nanoparticles on Langerhans cells, H. Nabeshi,T. Yoshikawa,K. Matsuyama,Y. Nakazato,A. Arimori,M. Isobe,S. Tochigi,S. Kondoh,T. Hirai,T. Akase,T. Yamashita,K. Yamashita,T. Yoshida,K. Nagano,Y. Abe,Y. Yoshioka,H. Kamada,T. Imazawa,N. Itoh,S. Tsunoda,Y. Tsutsumi, PHARMAZIE, GOVI-VERLAG PHARMAZEUTISCHER VERLAG GMBH, Vol. 65, No. 3, p. 199-201, 2010/03
Creation of lysine-deficient mutant lymphotoxin-α with receptor selectivity by using a phage display system, Yasuo Yoshioka,Hikaru Watanabe,Tomohiro Morishige,Xinglei Yao,Shinji Ikemizu,Chioko Nagao,Shandar Ahmad,Kenji Mizuguchi,Shin-ichi Tsunoda,Yasuo Tsutsumi,Yohei Mukai,Naoki Okada,Shinsaku Nakagawa, Biomaterials, Vol. 31, No. 7, p. 1935-1943, 2010/03
Size-dependent cytotoxic effects of amorphous silica nanoparticles on Langerhans cells, H. Nabeshi,T. Yoshikawa,K. Matsuyama,Y. Nakazato,A. Arimori,M. Isobe,S. Tochigi,S. Kondoh,T. Hirai,T. Akase,T. Yamashita,K. Yamashita,T. Yoshida,K. Nagano,Y. Abe,Y. Yoshioka,H. Kamada,T. Imazawa,N. Itoh,S. Tsunoda,Y. Tsutsumi, PHARMAZIE, GOVI-VERLAG PHARMAZEUTISCHER VERLAG GMBH, Vol. 65, No. 3, p. 199-201, 2010/03
Creation of lysine-deficient mutant lymphotoxin-alpha with receptor selectivity by using a phage display system, Yasuo Yoshioka,Hikaru Watanabe,Tomohiro Morishige,Xinglei Yao,Shinji Ikemizu,Chioko Nagao,Shandar Ahmad,Kenji Mizuguchi,Shin-ichi Tsunoda,Yasuo Tsutsumi,Yohei Mukai,Naoki Okada,Shinsaku Nakagawa, BIOMATERIALS, ELSEVIER SCI LTD, Vol. 31, No. 7, p. 1935-1943, 2010/03
Size-dependent cytotoxic effects of amorphous silica nanoparticles on Langerhans cells, H. Nabeshi,T. Yoshikawa,K. Matsuyama,Y. Nakazato,A. Arimori,M. Isobe,S. Tochigi,S. Kondoh,T. Hirai,T. Akase,T. Yamashita,K. Yamashita,T. Yoshida,K. Nagano,Y. Abe,Y. Yoshioka,H. Kamada,T. Imazawa,N. Itoh,S. Tsunoda,Y. Tsutsumi, PHARMAZIE, GOVI-VERLAG PHARMAZEUTISCHER VERLAG GMBH, Vol. 65, No. 3, p. 199-201, 2010/03
Creation of lysine-deficient mutant lymphotoxin-alpha with receptor selectivity by using a phage display system, Yasuo Yoshioka,Hikaru Watanabe,Tomohiro Morishige,Xinglei Yao,Shinji Ikemizu,Chioko Nagao,Shandar Ahmad,Kenji Mizuguchi,Shin-ichi Tsunoda,Yasuo Tsutsumi,Yohei Mukai,Naoki Okada,Shinsaku Nakagawa, BIOMATERIALS, ELSEVIER SCI LTD, Vol. 31, No. 7, p. 1935-1943, 2010/03
Creation of a lysine-deficient LIGHT mutant with the capacity for site-specific PEGylation and low affinity for a decoy receptor, Tomohiro Morishige,Yasuo Yoshioka,Hiroshi Inakura,Aya Tanabe,Xinglei Yao,Shin-ichi Tsunoda,Yasuo Tsutsumi,Yohei Mukai,Naoki Okada,Shinsaku Nakagawa, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC ELSEVIER SCIENCE, Vol. 393, No. 4, p. 888-893, 2010/03
Size-dependent cytotoxic effects of amorphous silica nanoparticles on Langerhans cells, H. Nabeshi,T. Yoshikawa,K. Matsuyama,Y. Nakazato,A. Arimori,M. Isobe,S. Tochigi,S. Kondoh,T. Hirai,T. Akase,T. Yamashita,K. Yamashita,T. Yoshida,K. Nagano,Y. Abe,Y. Yoshioka,H. Kamada,T. Imazawa,N. Itoh,S. Tsunoda,Y. Tsutsumi, PHARMAZIE, GOVI-VERLAG PHARMAZEUTISCHER VERLAG GMBH, Vol. 65, No. 3, p. 199-201, 2010/03
Size-dependent cytotoxic effects of amorphous silica nanoparticles on Langerhans cells, H. Nabeshi,T. Yoshikawa,K. Matsuyama,Y. Nakazato,A. Arimori,M. Isobe,S. Tochigi,S. Kondoh,T. Hirai,T. Akase,T. Yamashita,K. Yamashita,T. Yoshida,K. Nagano,Y. Abe,Y. Yoshioka,H. Kamada,T. Imazawa,N. Itoh,S. Tsunoda,Y. Tsutsumi, PHARMAZIE, GOVI-VERLAG PHARMAZEUTISCHER VERLAG GMBH, Vol. 65, No. 3, p. 199-201, 2010/03
Creation of lysine-deficient mutant lymphotoxin-alpha with receptor selectivity by using a phage display system, Yasuo Yoshioka,Hikaru Watanabe,Tomohiro Morishige,Xinglei Yao,Shinji Ikemizu,Chioko Nagao,Shandar Ahmad,Kenji Mizuguchi,Shin-ichi Tsunoda,Yasuo Tsutsumi,Yohei Mukai,Naoki Okada,Shinsaku Nakagawa, BIOMATERIALS, ELSEVIER SCI LTD, Vol. 31, No. 7, p. 1935-1943, 2010/03
Titanium dioxide induces different levels of IL-1β production dependent on its particle characteristics through caspase-1 activation mediated by reactive oxygen species and cathepsin B, Tomohiro Morishige,Yasuo Yoshioka,Aya Tanabe,Xinglei Yao,Shin-ichi Tsunoda,Yasuo Tsutsumi,Yohei Mukai,Naoki Okada,Shinsaku Nakagawa, Biochemical and Biophysical Research Communications, Vol. 392, No. 2, p. 160-165, 2010/02/05
Titanium dioxide induces different levels of IL-1β production dependent on its particle characteristics through caspase-1 activation mediated by reactive oxygen species and cathepsin B, Tomohiro Morishige,Yasuo Yoshioka,Aya Tanabe,Xinglei Yao,Shin-ichi Tsunoda,Yasuo Tsutsumi,Yohei Mukai,Naoki Okada,Shinsaku Nakagawa, Biochemical and Biophysical Research Communications, Vol. 392, No. 2, p. 160-165, 2010/02/05
Creation of an improved mutant TNF with TNFR1-selectivity and antagonistic activity by phage display technology, T. Nomura,Y. Abe,H. Kamada,M. Inoue,T. Kawara,S. Arita,T. Furuya,K. Minowa,Y. Yoshioka,H. Shibata,H. Kayamuro,T. Yamashita,K. Nagano,T. Yoshikawa,Y. Mukai,S. Nakagawa,S. Tsunoda,Y. Tsutsumi, PHARMAZIE, GOVI-VERLAG PHARMAZEUTISCHER VERLAG GMBH, Vol. 65, No. 2, p. 93-96, 2010/02
Creation of an improved mutant TNF with TNFR1-selectivity and antagonistic activity by phage display technology, T. Nomura,Y. Abe,H. Kamada,M. Inoue,T. Kawara,S. Arita,T. Furuya,K. Minowa,Y. Yoshioka,H. Shibata,H. Kayamuro,T. Yamashita,K. Nagano,T. Yoshikawa,Y. Mukai,S. Nakagawa,S. Tsunoda,Y. Tsutsumi, PHARMAZIE, GOVI-VERLAG PHARMAZEUTISCHER VERLAG GMBH, Vol. 65, No. 2, p. 93-96, 2010/02
Creation of an improved mutant TNF with TNFR1-selectivity and antagonistic activity by phage display technology, T. Nomura,Y. Abe,H. Kamada,M. Inoue,T. Kawara,S. Arita,T. Furuya,K. Minowa,Y. Yoshioka,H. Shibata,H. Kayamuro,T. Yamashita,K. Nagano,T. Yoshikawa,Y. Mukai,S. Nakagawa,S. Tsunoda,Y. Tsutsumi, PHARMAZIE, GOVI-VERLAG PHARMAZEUTISCHER VERLAG GMBH, Vol. 65, No. 2, p. 93-96, 2010/02
Titanium dioxide induces different levels of IL-1 beta production dependent on its particle characteristics through caspase-1 activation mediated by reactive oxygen species and cathepsin B, Tomohiro Morishige,Yasuo Yoshioka,Aya Tanabe,Xinglei Yao,Shin-ichi Tsunoda,Yasuo Tsutsumi,Yohei Mukai,Naoki Okada,Shinsaku Nakagawa, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC ELSEVIER SCIENCE, Vol. 392, No. 2, p. 160-165, 2010/02
Creation of an improved mutant TNF with TNFR1-selectivity and antagonistic activity by phage display technology, T. Nomura,Y. Abe,H. Kamada,M. Inoue,T. Kawara,S. Arita,T. Furuya,K. Minowa,Y. Yoshioka,H. Shibata,H. Kayamuro,T. Yamashita,K. Nagano,T. Yoshikawa,Y. Mukai,S. Nakagawa,S. Tsunoda,Y. Tsutsumi, PHARMAZIE, GOVI-VERLAG PHARMAZEUTISCHER VERLAG GMBH, Vol. 65, No. 2, p. 93-96, 2010/02
Titanium dioxide induces different levels of IL-1 beta production dependent on its particle characteristics through caspase-1 activation mediated by reactive oxygen species and cathepsin B, Tomohiro Morishige,Yasuo Yoshioka,Aya Tanabe,Xinglei Yao,Shin-ichi Tsunoda,Yasuo Tsutsumi,Yohei Mukai,Naoki Okada,Shinsaku Nakagawa, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC ELSEVIER SCIENCE, Vol. 392, No. 2, p. 160-165, 2010/02
化粧品ナノマテリアルの安全性評価の現状と技術的課題～安全なナノマテリアルの開発支援に向けて～, 吉川友章,吉岡靖雄,角田慎一,堤康央, コスメティックステージ, 技術情報協会, Vol. Vol.4(4): 44-48, No. 4, p. 44-48, 2010
Comparison of the anti-tumor activity of native, secreted, and membrane-bound LIGHT in mouse tumor models., Tomohiro Morishige,Yasuo Yoshioka,Aya Tanabe,Xinglei Yao,Hiroyuki Mizuguchi,Shin-ichi Tsunoda,Yasuo Tsutsumi,Yohei Mukai,Naoki Okada,Shinsaku Nakagawa, International immunopharmacology, Vol. 10, No. 1, p. 26-33, 2010/01
Creation of TNFR1-selective Antagonist and Its Therapeutic Effects, Tetsuya Nomura,Yasuhiro Abe,Yasuo Yoshioka,Shinsaku Nakagawa,Shin-ichi Tsunoda,Yasuo Tsutsumi, YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, PHARMACEUTICAL SOC JAPAN, Vol. 130, No. 1, p. 63-68, 2010/01
Application of Bioactive Mutant TNF Alpha to a Mucosal Vaccine Adjuvant, Hiroyuki Kayamuro,Yasuo Yoshioka,Yasuhiro Abe,Haruhiko Kamada,Shin-ichi Tsunoda,Yasuo Tsutsumi, YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, PHARMACEUTICAL SOC JAPAN, Vol. 130, No. 1, p. 55-61, 2010/01
非晶質ナノシリカの経皮吸収性/生体内動態と安全性との連関追求, ナノ材料のリスク評価と安全性対策, Vol. 44-53, 2010
Nano-Safety Science for Assuring the Safety of Nanomaterials, YOSHIOKA Yasuo,YOSHIKAWA Tomoaki,TSUTSUMI Yasuo, Nippon Eiseigaku Zasshi (Japanese Journal of Hygiene), The Japanese Society for Hygiene, Vol. 65, No. 4, p. 487-492, 2010
Arsenic trioxide alters expression and oxidative modification of the proteome in leukemic cells., Pharmazie, Vol. 65:702-707, 2010
ナノマテリアルのヒト健康への影響, 阪大NEWS LETTER, Vol. Vol.48(6): 19, 2010
Structure of the TNF-TNFR2 complex: crystal structure and supra-complex on the living cell surface., Sci Signal., Vol. in press, 2010
Safety analysis of newly-created nanomaterials for developing safe and convenience society based on innovative technologies, Vol. 第62巻, 第4号, p52-56, No. 4, p. 52-56, 2010
Development of TNF-based mucosal vaccine adjuvant for targeting infectious diseases., Advances in TNF Family Research : Proceedings of the 12th International TNF Conference 2009, 2010
Development of functional cytokines as novel mucosal vaccine adjuvants, Hiroyuki Kayamuro,Shin-Ichi Tsunoda,Yasuo Tsutsumi, Drug Delivery System, Vol. 25, No. 1, p. 22-28, 2010
Nano-Safety Science for Assuring the Safety of Nanomaterials, YOSHIOKA Yasuo,YOSHIKAWA Tomoaki,TSUTSUMI Yasuo, Nippon Eiseigaku Zasshi (Japanese Journal of Hygiene), The Japanese Society for Hygiene, Vol. 65(4):487-492, No. 4, p. 487-492, 2010
Safety evaluation study of nanomaterials aimed at the promotion of the social reception., Genes and Environment, 2010
創薬プロテオミクスとDDSの融合によるバイオ医薬の開発に向けて, Progress in Drug Delivery System <Biomedical Research Foundation (Tokyo)>, Vol. XIX:5-10, 2010
Comparison of the anti-tumor activity of native, secreted, and membrane-bound LIGHT in mouse tumor models., Tomohiro Morishige,Yasuo Yoshioka,Aya Tanabe,Xinglei Yao,Hiroyuki Mizuguchi,Shin-ichi Tsunoda,Yasuo Tsutsumi,Yohei Mukai,Naoki Okada,Shinsaku Nakagawa, International immunopharmacology, Vol. 10, No. 1, p. 26-33, 2010/01
Creation of TNFR1-selective Antagonist and Its Therapeutic Effects, Tetsuya Nomura,Yasuhiro Abe,Yasuo Yoshioka,Shinsaku Nakagawa,Shin-ichi Tsunoda,Yasuo Tsutsumi, YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, PHARMACEUTICAL SOC JAPAN, Vol. 130, No. 1, p. 63-68, 2010/01
Application of Bioactive Mutant TNF Alpha to a Mucosal Vaccine Adjuvant, Hiroyuki Kayamuro,Yasuo Yoshioka,Yasuhiro Abe,Haruhiko Kamada,Shin-ichi Tsunoda,Yasuo Tsutsumi, YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, PHARMACEUTICAL SOC JAPAN, Vol. 130, No. 1, p. 55-61, 2010/01
Comparison of the anti-tumor activity of native, secreted, and membrane-bound LIGHT in mouse tumor models, Tomohiro Morishige,Yasuo Yoshioka,Aya Tanabe,Xinglei Yao,Hiroyuki Mizuguchi,Shin-ichi Tsunoda,Yasuo Tsutsumi,Yohei Mukai,Naoki Okada,Shinsaku Nakagawa, INTERNATIONAL IMMUNOPHARMACOLOGY, ELSEVIER SCIENCE BV, Vol. 10, No. 1, p. 26-33, 2010/01
Arsenic trioxide alters expression and oxidative modification of the proteome in leukemic cells., Pharmazie, Vol. 65:702-707, 2010
ナノマテリアルの安全確保に向けたNano-Safety Science研究, 日本衛生学会誌, 2010
Structure of the TNF-TNFR2 complex: crystal structure and supra-complex on the living cell surface., Sci Signal., Vol. in press, 2010
Development of TNF-based mucosal vaccine adjuvant for targeting infectious diseases., Advances in TNF Family Research : Proceedings of the 12th International TNF Conference 2009, 2010
Nano-safety science for assuring the safety of nanomaterials., YOSHIOKA Yasuo,YOSHIKAWA Tomoaki,TSUTSUMI Yasuo, Nippon Eiseigaku Zasshi, The Japanese Society for Hygiene, Vol. 65(4):487-492, No. 4, p. 487-492, 2010
Safety evaluation study of nanomaterials aimed at the promotion of the social reception., Genes and Environment, 2010
Comparison of the anti-tumor activity of native, secreted, and membrane-bound LIGHT in mouse tumor models., Tomohiro Morishige,Yasuo Yoshioka,Aya Tanabe,Xinglei Yao,Hiroyuki Mizuguchi,Shin-ichi Tsunoda,Yasuo Tsutsumi,Yohei Mukai,Naoki Okada,Shinsaku Nakagawa, International immunopharmacology, Vol. 10, No. 1, p. 26-33, 2010/01
Comparison of the anti-tumor activity of native, secreted, and membrane-bound LIGHT in mouse tumor models, Tomohiro Morishige,Yasuo Yoshioka,Aya Tanabe,Xinglei Yao,Hiroyuki Mizuguchi,Shin-ichi Tsunoda,Yasuo Tsutsumi,Yohei Mukai,Naoki Okada,Shinsaku Nakagawa, INTERNATIONAL IMMUNOPHARMACOLOGY, ELSEVIER SCIENCE BV, Vol. 10, No. 1, p. 26-33, 2010/01
LIGHT protein suppresses tumor growth by augmentation of immune response, Tomohiro Morishige,Yasuo Yoshioka,Hiroshi Inakura,Aya Tanabe,Hikaru Watanabe,Xinglei Yao,Shin-ichi Tsunoda,Yasuo Tsutsumi,Yohei Mukai,Naoki Okada,Shinsaku Nakagawa, Immunology Letters, Vol. 127, No. 1, p. 33-38, 2009/12/02
LIGHT protein suppresses tumor growth by augmentation of immune response, Tomohiro Morishige,Yasuo Yoshioka,Hiroshi Inakura,Aya Tanabe,Hikaru Watanabe,Xinglei Yao,Shin-ichi Tsunoda,Yasuo Tsutsumi,Yohei Mukai,Naoki Okada,Shinsaku Nakagawa, Immunology Letters, Vol. 127, No. 1, p. 33-38, 2009/12/02
The treatment of established murine collagen-induced arthritis with a TNFR1-selective antagonistic mutant TNF, Hiroko Shibata,Yasuo Yoshioka,Yasuhiro Abe,Akiko Ohkawa,Tetsuya Nomura,Kyoko Minowa,Yohei Mukai,Shinsaku Nakagawa,Madoka Taniai,Tsunetaka Ohta,Haruhiko Kamada,Shin-ichi Tsunoda,Yasuo Tsutsumi, BIOMATERIALS, ELSEVIER SCI LTD, Vol. 30, No. 34, p. 6638-6647, 2009/12
LIGHT protein suppresses tumor growth by augmentation of immune response, Tomohiro Morishige,Yasuo Yoshioka,Hiroshi Inakura,Aya Tanabe,Hikaru Watanabe,Xinglei Yao,Shin-ichi Tsunoda,Yasuo Tsutsumi,Yohei Mukai,Naoki Okada,Shinsaku Nakagawa, IMMUNOLOGY LETTERS, ELSEVIER SCIENCE BV, Vol. 127, No. 1, p. 33-38, 2009/12
The treatment of established murine collagen-induced arthritis with a TNFR1-selective antagonistic mutant TNF, Hiroko Shibata,Yasuo Yoshioka,Yasuhiro Abe,Akiko Ohkawa,Tetsuya Nomura,Kyoko Minowa,Yohei Mukai,Shinsaku Nakagawa,Madoka Taniai,Tsunetaka Ohta,Haruhiko Kamada,Shin-ichi Tsunoda,Yasuo Tsutsumi, BIOMATERIALS, ELSEVIER SCI LTD, Vol. 30, No. 34, p. 6638-6647, 2009/12
The treatment of established murine collagen-induced arthritis with a TNFR1-selective antagonistic mutant TNF, Hiroko Shibata,Yasuo Yoshioka,Yasuhiro Abe,Akiko Ohkawa,Tetsuya Nomura,Kyoko Minowa,Yohei Mukai,Shinsaku Nakagawa,Madoka Taniai,Tsunetaka Ohta,Haruhiko Kamada,Shin-ichi Tsunoda,Yasuo Tsutsumi, BIOMATERIALS, ELSEVIER SCI LTD, Vol. 30, No. 34, p. 6638-6647, 2009/12
The treatment of established murine collagen-induced arthritis with a TNFR1-selective antagonistic mutant TNF, Hiroko Shibata,Yasuo Yoshioka,Yasuhiro Abe,Akiko Ohkawa,Tetsuya Nomura,Kyoko Minowa,Yohei Mukai,Shinsaku Nakagawa,Madoka Taniai,Tsunetaka Ohta,Haruhiko Kamada,Shin-ichi Tsunoda,Yasuo Tsutsumi, Biomaterials, Vol. 30, No. 34, p. 6638-6647, 2009/12
The treatment of established murine collagen-induced arthritis with a TNFR1-selective antagonistic mutant TNF, Hiroko Shibata,Yasuo Yoshioka,Yasuhiro Abe,Akiko Ohkawa,Tetsuya Nomura,Kyoko Minowa,Yohei Mukai,Shinsaku Nakagawa,Madoka Taniai,Tsunetaka Ohta,Haruhiko Kamada,Shin-ichi Tsunoda,Yasuo Tsutsumi, BIOMATERIALS, ELSEVIER SCI LTD, Vol. 30, No. 34, p. 6638-6647, 2009/12
LIGHT protein suppresses tumor growth by augmentation of immune response, Tomohiro Morishige,Yasuo Yoshioka,Hiroshi Inakura,Aya Tanabe,Hikaru Watanabe,Xinglei Yao,Shin-ichi Tsunoda,Yasuo Tsutsumi,Yohei Mukai,Naoki Okada,Shinsaku Nakagawa, IMMUNOLOGY LETTERS, ELSEVIER SCIENCE BV, Vol. 127, No. 1, p. 33-38, 2009/12
The treatment of established murine collagen-induced arthritis with a TNFR1-selective antagonistic mutant TNF, Hiroko Shibata,Yasuo Yoshioka,Yasuhiro Abe,Akiko Ohkawa,Tetsuya Nomura,Kyoko Minowa,Yohei Mukai,Shinsaku Nakagawa,Madoka Taniai,Tsunetaka Ohta,Haruhiko Kamada,Shin-ichi Tsunoda,Yasuo Tsutsumi, BIOMATERIALS, ELSEVIER SCI LTD, Vol. 30, No. 34, p. 6638-6647, 2009/12
LIGHT protein suppresses tumor growth by augmentation of immune response, Tomohiro Morishige,Yasuo Yoshioka,Hiroshi Inakura,Aya Tanabe,Hikaru Watanabe,Xinglei Yao,Shin-ichi Tsunoda,Yasuo Tsutsumi,Yohei Mukai,Naoki Okada,Shinsaku Nakagawa, IMMUNOLOGY LETTERS, ELSEVIER SCIENCE BV, Vol. 127, No. 1, p. 33-38, 2009/12
The treatment of established murine collagen-induced arthritis with a TNFR1-selective antagonistic mutant TNF, Hiroko Shibata,Yasuo Yoshioka,Yasuhiro Abe,Akiko Ohkawa,Tetsuya Nomura,Kyoko Minowa,Yohei Mukai,Shinsaku Nakagawa,Madoka Taniai,Tsunetaka Ohta,Haruhiko Kamada,Shin-ichi Tsunoda,Yasuo Tsutsumi, BIOMATERIALS, ELSEVIER SCI LTD, Vol. 30, No. 34, p. 6638-6647, 2009/12
LIGHT protein suppresses tumor growth by augmentation of immune response, Tomohiro Morishige,Yasuo Yoshioka,Hiroshi Inakura,Aya Tanabe,Hikaru Watanabe,Xinglei Yao,Shin-ichi Tsunoda,Yasuo Tsutsumi,Yohei Mukai,Naoki Okada,Shinsaku Nakagawa, IMMUNOLOGY LETTERS, ELSEVIER SCIENCE BV, Vol. 127, No. 1, p. 33-38, 2009/12
The treatment of established murine collagen-induced arthritis with a TNFR1-selective antagonistic mutant TNF, Hiroko Shibata,Yasuo Yoshioka,Yasuhiro Abe,Akiko Ohkawa,Tetsuya Nomura,Kyoko Minowa,Yohei Mukai,Shinsaku Nakagawa,Madoka Taniai,Tsunetaka Ohta,Haruhiko Kamada,Shin-ichi Tsunoda,Yasuo Tsutsumi, BIOMATERIALS, ELSEVIER SCI LTD, Vol. 30, No. 34, p. 6638-6647, 2009/12
LIGHT protein suppresses tumor growth by augmentation of immune response, Tomohiro Morishige,Yasuo Yoshioka,Hiroshi Inakura,Aya Tanabe,Hikaru Watanabe,Xinglei Yao,Shin-ichi Tsunoda,Yasuo Tsutsumi,Yohei Mukai,Naoki Okada,Shinsaku Nakagawa, IMMUNOLOGY LETTERS, ELSEVIER SCIENCE BV, Vol. 127, No. 1, p. 33-38, 2009/12
Antibody‐drug conjugateの開発に適う細胞内侵入抗体の効率的探索法, 吉川舞,向洋平,吉岡靖雄,岡田直貴,堤康央,角田慎一,中川晋作, 次世代を担う若手ファーマ・バイオフォーラム講演要旨集, Vol. 8th, 2009/11/02
Novel protein engineering strategy for creating highly receptor-selective mutant TNFs, Tetsuya Nomura,Yasuhiro Abe,Haruhiko Kamada,Masaki Inoue,Tomoyuki Kawara,Shuhei Arita,Takeshi Furuya,Yasuo Yoshioka,Hiroko Shibata,Hiroyuki Kayamuro,Takuya Yamashita,Kazuya Nagano,Tomoaki Yoshikawa,Yohei Mukai,Shinsaku Nakagawa,Madoka Taniai,Tsunetaka Ohta,Shin-ichi Tsunoda,Yasuo Tsutsumi, Biochemical and Biophysical Research Communications, Vol. 388, No. 4, p. 667-671, 2009/10/30
ナノマテリアルの安全確保に向けて―1 ナノマテリアルの経皮吸収性・体内動態と急性毒性・肝毒性, 角田慎一,吉川友章,鍋師裕美,赤瀬貴憲,長野一也,阿部康弘,吉岡靖雄,今澤孝喜,向洋平,岡田直貴,中川晋作,堤康央, 日本食品衛生学会学術講演会講演要旨集, Vol. 98th, 2009/10/08
ナノマテリアルの安全確保に向けて―4 ナノマテリアルの動態特性と免疫毒性, 吉岡靖雄,森重智弘,稲倉裕,吉田徳幸,藤村真穂,鍋師裕美,阿部康弘,長野一也,吉川友章,今澤孝喜,角田慎一,向洋平,岡田直貴,堤康央,中川晋作, 日本食品衛生学会学術講演会講演要旨集, Vol. 98th, 2009/10/08
Creation of a mutant IFN-alpha 8 with enhanced anti-HCV activity using the phage display technique, Tomoyuki Kawara,Yasuhiro Abe,Haruhiko Kamada,Shin-ichi Tsunoda,Masuo Kondoh,Yasuo Tsutsumi,Kiyohito Yagi, CYTOKINE, ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, Vol. 48, No. 1-2, p. 58-58, 2009/10
Frequent expression of TRAIL-R2 in human breast tumors revealed by antibody proteomics technology, Z. Kazuya Nagano,Takuya Yamashita,Takayuki Okamura,Takanobu Watanabe,Souichiro Kanasaki,Yasuhiro Abe,Haruhiko Kamada,Shin-ichi Tsunoda,Yasuo Tsutsumi, CYTOKINE, ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, Vol. 48, No. 1-2, p. 54-55, 2009/10
Cancer hazard of carbon nanotubes: Size/shape-dependent induction of DNA damage and inflammation, Kohei Yamashita,Yasuo Yoshioka,Hiroyuki Kayamuro,Tokuyuki Yoshida,Kazuma Higashisaka,Yasuhiro Abe,Tomoaki Yoshikawa,Norio Itoh,Shin-ichi Tsunoda,Yasuo Tsutsumi, CYTOKINE, ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, Vol. 48, No. 1-2, p. 55-55, 2009/10
The use of a mutant TNF-alpha as a vaccine adjuvant for the induction of mucosal immune responses, Hiroyuki Kayamuro,Yasuhiro Abe,Yasuo Yoshioka,Kazufumi Katayama,Tetsuya Nomura,Tokuyuki Yoshida,Kohei Yamashita,Tomoaki Yoshikawa,Yuichi Kawai,Tadanori Mayumi,Takachika Hiroi,Norio Itoh,Kazuya Nagano,Haruhiko Kamada,Shin-ichi Tsunoda,Yasuo Tsutsumi, BIOMATERIALS, ELSEVIER SCI LTD, Vol. 30, No. 29, p. 5869-5876, 2009/10
A Novel Tumor-Targeted Therapy Using a Claudin-4-Targeting Molecule, Rie Saeki,Masuo Kondoh,Hideki Kakutani,Shin-ichi Tsunoda,Yasuhiro Mochizuki,Takao Hamakubo,Yasuo Tsutsumi,Yasuhiko Horiguchi,Kiyohito Yagi, MOLECULAR PHARMACOLOGY, AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS, Vol. 76, No. 4, p. 918-926, 2009/10
Novel protein engineering strategy for creating highly receptor-selective mutant TNFs, Tetsuya Nomura,Yasuhiro Abe,Haruhiko Kamada,Masaki Inoue,Tomoyuki Kawara,Shuhei Arita,Takeshi Furuya,Yasuo Yoshioka,Hiroko Shibata,Hiroyuki Kayamuro,Takuya Yamashita,Kazuya Nagano,Tomoaki Yoshikawa,Yohei Mukai,Shinsaku Nakagawa,Madoka Taniai,Tsunetaka Ohta,Shin-ichi Tsunoda,Yasuo Tsutsumi, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC ELSEVIER SCIENCE, Vol. 388, No. 4, p. 667-671, 2009/10
Novel protein engineering strategy for creating highly receptor-selective mutant TNFs, Tetsuya Nomura,Yasuhiro Abe,Haruhiko Kamada,Masaki Inoue,Tomoyuki Kawara,Shuhei Arita,Takeshi Furuya,Yasuo Yoshioka,Hiroko Shibata,Hiroyuki Kayamuro,Takuya Yamashita,Kazuya Nagano,Tomoaki Yoshikawa,Yohei Mukai,Shinsaku Nakagawa,Madoka Taniai,Tsunetaka Ohta,Shin-ichi Tsunoda,Yasuo Tsutsumi, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC ELSEVIER SCIENCE, Vol. 388, No. 4, p. 667-671, 2009/10
The use of a mutant TNF-alpha as a vaccine adjuvant for the induction of mucosal immune responses, Hiroyuki Kayamuro,Yasuhiro Abe,Yasuo Yoshioka,Kazufumi Katayama,Tetsuya Nomura,Tokuyuki Yoshida,Kohei Yamashita,Tomoaki Yoshikawa,Yuichi Kawai,Tadanori Mayumi,Takachika Hiroi,Norio Itoh,Kazuya Nagano,Haruhiko Kamada,Shin-ichi Tsunoda,Yasuo Tsutsumi, BIOMATERIALS, ELSEVIER SCI LTD, Vol. 30, No. 29, p. 5869-5876, 2009/10
Novel protein engineering strategy for creating highly receptor-selective mutant TNFs, Tetsuya Nomura,Yasuhiro Abe,Haruhiko Kamada,Masaki Inoue,Tomoyuki Kawara,Shuhei Arita,Takeshi Furuya,Yasuo Yoshioka,Hiroko Shibata,Hiroyuki Kayamuro,Takuya Yamashita,Kazuya Nagano,Tomoaki Yoshikawa,Yohei Mukai,Shinsaku Nakagawa,Madoka Taniai,Tsunetaka Ohta,Shin-ichi Tsunoda,Yasuo Tsutsumi, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC ELSEVIER SCIENCE, Vol. 388, No. 4, p. 667-671, 2009/10
A novel tumor-targeted therapy using a claudin-4-targeting molecule, Rie Saeki,Masuo Kondoh,Hideki Kakutani,Shin-Ichi Tsunoda,Yasuhiro Mochizuki,Takao Hamakubo,Yasuo Tsutsumi,Yasuhiko Horiguchi,Kiyohito Yagi, Molecular Pharmacology, Vol. 76, No. 4, p. 918-926, 2009/10
Creation of lysine-deficient mutant lymphotoxin-alpha with receptor selectivity by using phage display, Yasuo Yoshioka,Hikaru Watanabe,Tomohiro Morishige,Xinglei Yao,Shinji Ikemizu,Chioko Nagao,Shandar Ahmad,Kenji Mizuguchi,Yasuo Tsutsumi,Yohei Mukai,Naoki Okada,Shinsaku Nakagawa, CYTOKINE, ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, Vol. 48, No. 1-2, p. 111-111, 2009/10
A Novel Tumor-Targeted Therapy Using a Claudin-4-Targeting Molecule, Rie Saeki,Masuo Kondoh,Hideki Kakutani,Shin-ichi Tsunoda,Yasuhiro Mochizuki,Takao Hamakubo,Yasuo Tsutsumi,Yasuhiko Horiguchi,Kiyohito Yagi, MOLECULAR PHARMACOLOGY, AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS, Vol. 76, No. 4, p. 918-926, 2009/10
Novel protein engineering strategy for creating highly receptor-selective mutant TNFs, Tetsuya Nomura,Yasuhiro Abe,Haruhiko Kamada,Masaki Inoue,Tomoyuki Kawara,Shuhei Arita,Takeshi Furuya,Yasuo Yoshioka,Hiroko Shibata,Hiroyuki Kayamuro,Takuya Yamashita,Kazuya Nagano,Tomoaki Yoshikawa,Yohei Mukai,Shinsaku Nakagawa,Madoka Taniai,Tsunetaka Ohta,Shin-ichi Tsunoda,Yasuo Tsutsumi, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC ELSEVIER SCIENCE, Vol. 388, No. 4, p. 667-671, 2009/10
The use of a mutant TNF-alpha as a vaccine adjuvant for the induction of mucosal immune responses, Hiroyuki Kayamuro,Yasuhiro Abe,Yasuo Yoshioka,Kazufumi Katayama,Tetsuya Nomura,Tokuyuki Yoshida,Kohei Yamashita,Tomoaki Yoshikawa,Yuichi Kawai,Tadanori Mayumi,Takachika Hiroi,Norio Itoh,Kazuya Nagano,Haruhiko Kamada,Shin-ichi Tsunoda,Yasuo Tsutsumi, BIOMATERIALS, ELSEVIER SCI LTD, Vol. 30, No. 29, p. 5869-5876, 2009/10
Novel protein engineering strategy for creating highly receptor-selective mutant TNFs, Tetsuya Nomura,Yasuhiro Abe,Haruhiko Kamada,Masaki Inoue,Tomoyuki Kawara,Shuhei Arita,Takeshi Furuya,Yasuo Yoshioka,Hiroko Shibata,Hiroyuki Kayamuro,Takuya Yamashita,Kazuya Nagano,Tomoaki Yoshikawa,Yohei Mukai,Shinsaku Nakagawa,Madoka Taniai,Tsunetaka Ohta,Shin-ichi Tsunoda,Yasuo Tsutsumi, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC ELSEVIER SCIENCE, Vol. 388, No. 4, p. 667-671, 2009/10
A Novel Tumor-Targeted Therapy Using a Claudin-4-Targeting Molecule, Rie Saeki,Masuo Kondoh,Hideki Kakutani,Shin-ichi Tsunoda,Yasuhiro Mochizuki,Takao Hamakubo,Yasuo Tsutsumi,Yasuhiko Horiguchi,Kiyohito Yagi, MOLECULAR PHARMACOLOGY, AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS, Vol. 76, No. 4, p. 918-926, 2009/10
The use of a mutant TNF-alpha as a vaccine adjuvant for the induction of mucosal immune responses, Hiroyuki Kayamuro,Yasuhiro Abe,Yasuo Yoshioka,Kazufumi Katayama,Tetsuya Nomura,Tokuyuki Yoshida,Kohei Yamashita,Tomoaki Yoshikawa,Yuichi Kawai,Tadanori Mayumi,Takachika Hiroi,Norio Itoh,Kazuya Nagano,Haruhiko Kamada,Shin-ichi Tsunoda,Yasuo Tsutsumi, BIOMATERIALS, ELSEVIER SCI LTD, Vol. 30, No. 29, p. 5869-5876, 2009/10
Novel protein engineering strategy for creating highly receptor-selective mutant TNFs, Tetsuya Nomura,Yasuhiro Abe,Haruhiko Kamada,Masaki Inoue,Tomoyuki Kawara,Shuhei Arita,Takeshi Furuya,Yasuo Yoshioka,Hiroko Shibata,Hiroyuki Kayamuro,Takuya Yamashita,Kazuya Nagano,Tomoaki Yoshikawa,Yohei Mukai,Shinsaku Nakagawa,Madoka Taniai,Tsunetaka Ohta,Shin-ichi Tsunoda,Yasuo Tsutsumi, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC ELSEVIER SCIENCE, Vol. 388, No. 4, p. 667-671, 2009/10
Novel protein engineering strategy for creating highly receptor-selective mutant TNFs, Tetsuya Nomura,Yasuhiro Abe,Haruhiko Kamada,Masaki Inoue,Tomoyuki Kawara,Shuhei Arita,Takeshi Furuya,Yasuo Yoshioka,Hiroko Shibata,Hiroyuki Kayamuro,Takuya Yamashita,Kazuya Nagano,Tomoaki Yoshikawa,Yohei Mukai,Shinsaku Nakagawa,Madoka Taniai,Tsunetaka Ohta,Shin-ichi Tsunoda,Yasuo Tsutsumi, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC ELSEVIER SCIENCE, Vol. 388, No. 4, p. 667-671, 2009/10
Creation of lysine-deficient mutant lymphotoxin-alpha with receptor selectivity by using phage display, Yasuo Yoshioka,Hikaru Watanabe,Tomohiro Morishige,Xinglei Yao,Shinji Ikemizu,Chioko Nagao,Shandar Ahmad,Kenji Mizuguchi,Yasuo Tsutsumi,Yohei Mukai,Naoki Okada,Shinsaku Nakagawa, CYTOKINE, ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, Vol. 48, No. 1-2, p. 111-111, 2009/10
新規香粧品素材として注目されるナノシリカの経皮リスクに関する基礎検討, 松尾一彦,免山智行,角田慎一,堤康央,向洋平,吉岡靖雄,岡田直貴,中川晋作, 日本香粧品学会誌, 日本香粧品学会, Vol. 33, No. 3, p. 218-219, 2009/09/30
ファージ表面提示法を駆使した活性増強型TNF変異体の創出とその特性, 鎌田春彦,阿部康弘,吉岡靖雄,野村鉄也,萱室裕之,向洋平,中川晋作,角田慎一,堤康央, 生化学, (公社)日本生化学会, Vol. 82回, p. ROMBUNNO.2P-404-404, 2009/09/25
Urban aerosol directly stimulates antigen presentation cells in vitro and cause airway inflammation in vivo, Tokuyuki Yoshida,Yasuo Yoshioka,Hiroyuki Kayamuro,Kohei Yamashita,Kazuma Higashisaka,Ryosuke Nakanishi,Yasuhiro Abe,Yu-ichi Kawai,Tadanori Mayumi,Tadanori Yoshikawa,Norio Itoh,Shin-ichi Tsunoda,Yasuo Tsutsumi, TOXICOLOGY LETTERS, ELSEVIER IRELAND LTD, Vol. 189, p. S176-S177, 2009/09
Evaluation of size-dependent acute toxicity and toxicokinetics of amorphous nanosilicas, Hiromi Nabeshi,Tomoaki Yoshikawa,Keigo Matsuyama,Yasutaro Nakazato,Takayoshi Imazawa,Yasuo Yoshioka,Yasuhiro Abe,Yu-ichi Kawai,Tadanori Mayumi,Norio Ito,Shin-ichi Tsunoda,Yasuo Tsutsumi, TOXICOLOGY LETTERS, ELSEVIER IRELAND LTD, Vol. 189, p. S181-S182, 2009/09
Differential acute toxicity and toxicokinetics of amorphous nanosilicas: The role of surface physicochemical properties, Yasutaro Nakazato,Tomoaki Yoshikawa,Hiromi Nabeshi,Keigo Matsuyama,Takayoshi Imazawa,Yasuo Yoshioka,Yasuhiro Abe,Yu-ichi Kawai,Tadanori Mayumi,Norio Itoh,Shin-ichi Tsunoda,Yasuo Tsutsumi, TOXICOLOGY LETTERS, ELSEVIER IRELAND LTD, Vol. 189, p. S183-S183, 2009/09
Evaluation of size-dependent intracellular distribution and genotoxicity of amorphous nanosilicas in human keratinocytes, Keigo Matsuyama,Tomoaki Yoshikawa,Hiromi Nabeshi,Yasutaro Nakazato,Takayoshi Imazawa,Yasuo Yoshioka,Yasuhiro Abe,Yu-ichi Kawai,Tadanori Mayumi,Norio Itoh,Shin-ichi Tsunoda,Yasuo Tsutsumi, TOXICOLOGY LETTERS, ELSEVIER IRELAND LTD, Vol. 189, p. S183-S183, 2009/09
In vitro nanotoxicologic studies of silica-nanoparticles using dermal cell lines, Tomoaki Yoshikawa,Hiromi Nabeshi,Keigo Matsuyama,Yasutaro Nakazato,Takayoshi Imazawa,Yasuo Yoshioka,Yasuhiro Abe,Yu-ichi Kawai,Tadanori Mayumi,Norio Itoh,Shin-ichi Tsunoda,Yasuo Tsutsumi, TOXICOLOGY LETTERS, ELSEVIER IRELAND LTD, Vol. 189, p. S179-S180, 2009/09
Ligand independent assembly of purified soluble Magic Roundabout (Robo4), a tumour-specific endothelial marker, M. Yoshikawa,Y. Mukai,Y. Okada,Y. Yoshioka,S. Tsunoda,Y. Tsutsumi,N. Okada,A. William C,T. Doi,S. Nakagawa, EJC SUPPLEMENTS, PERGAMON-ELSEVIER SCIENCE LTD, Vol. 7, No. 2, p. 103-103, 2009/09
非晶質シリカの粒子特性と起炎性の連関評価, 吉岡靖雄,森重智弘,稲倉裕,田辺綾,堤康央,角田慎一,河合裕一,眞弓忠範,向洋平,岡田直貴,中川晋作, 日本免疫毒性学会講演抄録集, Vol. 16th, 2009/08/10
特定細胞内へのドラッグデリバリーを目指した細胞内侵入抗体の効率的な創製法の確立(High-throughput screening method of Cell-internalizing monoclonal antibodies, potent anti-tumor drug delivery carriers), 吉川舞,向洋平,吉岡靖雄,岡田直貴,堤康央,角田慎一,中川晋作, 日本癌学会総会記事, 日本癌学会, Vol. 68回, p. 283-283, 2009/08
Fast Binding Kinetics and Conserved 3D Structure Underlie the Antagonistic Activity of Mutant TNF: Useful Information for Designing Artificial Proteo-Antagonists, Yohei Mukai,Teruya Nakamura,Yasuo Yoshioka,Hiroko Shibata,Yasuhiro Abe,Tetsuya Nomura,Madoka Taniai,Tsunetaka Ohta,Shinsaku Nakagawa,Shin-ichi Tsunoda,Haruhiko Kamada,Yuriko Yamagata,Yasuo Tsutsumi, JOURNAL OF BIOCHEMISTRY, OXFORD UNIV PRESS, Vol. 146, No. 2, p. 167-172, 2009/08
Silica nanoparticles as hepatotoxicants, Hikaru Nishimori,Masuo Kondoh,Katsuhiro Isoda,Shin-ichi Tsunoda,Yasuo Tsutsumi,Kiyohito Yagi, EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, ELSEVIER SCIENCE BV, Vol. 72, No. 3, p. 496-501, 2009/08
Histological analysis of 70-nm silica particles-induced chronic toxicity in mice, Hikaru Nishimori,Masuo Kondoh,Katsuhiro Isoda,Shin-ichi Tsunoda,Yasuo Tsutsumi,Kiyohito Yagi, European Journal of Pharmaceutics and Biopharmaceutics, Vol. 72, No. 3, p. 626-629, 2009/08
Fast Binding Kinetics and Conserved 3D Structure Underlie the Antagonistic Activity of Mutant TNF: Useful Information for Designing Artificial Proteo-Antagonists, Yohei Mukai,Teruya Nakamura,Yasuo Yoshioka,Hiroko Shibata,Yasuhiro Abe,Tetsuya Nomura,Madoka Taniai,Tsunetaka Ohta,Shinsaku Nakagawa,Shin-ichi Tsunoda,Haruhiko Kamada,Yuriko Yamagata,Yasuo Tsutsumi, JOURNAL OF BIOCHEMISTRY, OXFORD UNIV PRESS, Vol. 146, No. 2, p. 167-172, 2009/08
Fast Binding Kinetics and Conserved 3D Structure Underlie the Antagonistic Activity of Mutant TNF: Useful Information for Designing Artificial Proteo-Antagonists, Yohei Mukai,Teruya Nakamura,Yasuo Yoshioka,Hiroko Shibata,Yasuhiro Abe,Tetsuya Nomura,Madoka Taniai,Tsunetaka Ohta,Shinsaku Nakagawa,Shin-ichi Tsunoda,Haruhiko Kamada,Yuriko Yamagata,Yasuo Tsutsumi, JOURNAL OF BIOCHEMISTRY, OXFORD UNIV PRESS, Vol. 146, No. 2, p. 167-172, 2009/08
Silica nanoparticles as hepatotoxicants, Hikaru Nishimori,Masuo Kondoh,Katsuhiro Isoda,Shin-ichi Tsunoda,Yasuo Tsutsumi,Kiyohito Yagi, EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, ELSEVIER SCIENCE BV, Vol. 72, No. 3, p. 496-501, 2009/08
Histological analysis of 70-nm silica particles-induced chronic toxicity in mice, Hikaru Nishimori,Masuo Kondoh,Katsuhiro Isoda,Shin-ichi Tsunoda,Yasuo Tsutsumi,Kiyohito Yagi, EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, ELSEVIER SCIENCE BV, Vol. 72, No. 3, p. 626-629, 2009/08
Fast Binding Kinetics and Conserved 3D Structure Underlie the Antagonistic Activity of Mutant TNF: Useful Information for Designing Artificial Proteo-Antagonists, Yohei Mukai,Teruya Nakamura,Yasuo Yoshioka,Hiroko Shibata,Yasuhiro Abe,Tetsuya Nomura,Madoka Taniai,Tsunetaka Ohta,Shinsaku Nakagawa,Shin-ichi Tsunoda,Haruhiko Kamada,Yuriko Yamagata,Yasuo Tsutsumi, JOURNAL OF BIOCHEMISTRY, OXFORD UNIV PRESS, Vol. 146, No. 2, p. 167-172, 2009/08
The augmentation of intracellular delivery of peptide therapeutics by artificial protein transduction domains, Tomoaki Yoshikawa,Toshiki Sugita,Yohei Mukai,Yasuhiro Abe,Shinsaku Nakagawa,Haruhiko Kamada,Shin-ichi Tsunoda,Yasuo Tsutsumi, BIOMATERIALS, ELSEVIER SCI LTD, Vol. 30, No. 19, p. 3318-3323, 2009/07
Arsenic Trioxide Inhibits Human T Cell-Lymphotropic Virus-1-Induced Syncytiums by Down-Regulating gp46, Hiromi Nabeshi,Tomoaki Yoshikawa,Haruhiko Kamada,Hiroko Shibata,Toshiki Sugita,Yasuhiro Abe,Kazuya Nagano,Tetsuya Nomura,Kyoko Minowa,Takuya Yamashita,Norio Itoh,Yasuo Yoshioka,Shin-ichi Tsunoda,Yasuo Tsutsumi, BIOLOGICAL & PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOC JAPAN, Vol. 32, No. 7, p. 1286-1288, 2009/07
TNF superfamily member, TL1A, is a potential mucosal vaccine adjuvant, Hiroyuki Kayamuro,Yasuo Yoshioka,Yasuhiro Abe,Kazufumi Katayama,Tokuyuki Yoshida,Kohei Yamashita,Tomoaki Yoshikawa,Takachika Hiroi,Norio Itoh,Yuichi Kawai,Tadanori Mayumi,Haruhiko Kamada,Shin-ichi Tsunoda,Yasuo Tsutsumi, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC ELSEVIER SCIENCE, Vol. 384, No. 3, p. 296-300, 2009/07
TNF superfamily member, TL1A, is a potential mucosal vaccine adjuvant, Hiroyuki Kayamuro,Yasuo Yoshioka,Yasuhiro Abe,Kazufumi Katayama,Tokuyuki Yoshida,Kohei Yamashita,Tomoaki Yoshikawa,Takachika Hiroi,Norio Itoh,Yuichi Kawai,Tadanori Mayumi,Haruhiko Kamada,Shin-ichi Tsunoda,Yasuo Tsutsumi, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC ELSEVIER SCIENCE, Vol. 384, No. 3, p. 296-300, 2009/07
Arsenic Trioxide Inhibits Human T Cell-Lymphotropic Virus-1-Induced Syncytiums by Down-Regulating gp46, Hiromi Nabeshi,Tomoaki Yoshikawa,Haruhiko Kamada,Hiroko Shibata,Toshiki Sugita,Yasuhiro Abe,Kazuya Nagano,Tetsuya Nomura,Kyoko Minowa,Takuya Yamashita,Norio Itoh,Yasuo Yoshioka,Shin-ichi Tsunoda,Yasuo Tsutsumi, BIOLOGICAL & PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOC JAPAN, Vol. 32, No. 7, p. 1286-1288, 2009/07
The augmentation of intracellular delivery of peptide therapeutics by artificial protein transduction domains, Tomoaki Yoshikawa,Toshiki Sugita,Yohei Mukai,Yasuhiro Abe,Shinsaku Nakagawa,Haruhiko Kamada,Shin-ichi Tsunoda,Yasuo Tsutsumi, BIOMATERIALS, ELSEVIER SCI LTD, Vol. 30, No. 19, p. 3318-3323, 2009/07
The augmentation of intracellular delivery of peptide therapeutics by artificial protein transduction domains, Tomoaki Yoshikawa,Toshiki Sugita,Yohei Mukai,Yasuhiro Abe,Shinsaku Nakagawa,Haruhiko Kamada,Shin-ichi Tsunoda,Yasuo Tsutsumi, BIOMATERIALS, ELSEVIER SCI LTD, Vol. 30, No. 19, p. 3318-3323, 2009/07
TNF superfamily member, TL1A, is a potential mucosal vaccine adjuvant, Hiroyuki Kayamuro,Yasuo Yoshioka,Yasuhiro Abe,Kazufumi Katayama,Tokuyuki Yoshida,Kohei Yamashita,Tomoaki Yoshikawa,Takachika Hiroi,Norio Itoh,Yuichi Kawai,Tadanori Mayumi,Haruhiko Kamada,Shin-ichi Tsunoda,Yasuo Tsutsumi, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC ELSEVIER SCIENCE, Vol. 384, No. 3, p. 296-300, 2009/07
Arsenic Trioxide Inhibits Human T Cell-Lymphotropic Virus-1-Induced Syncytiums by Down-Regulating gp46, Hiromi Nabeshi,Tomoaki Yoshikawa,Haruhiko Kamada,Hiroko Shibata,Toshiki Sugita,Yasuhiro Abe,Kazuya Nagano,Tetsuya Nomura,Kyoko Minowa,Takuya Yamashita,Norio Itoh,Yasuo Yoshioka,Shin-ichi Tsunoda,Yasuo Tsutsumi, BIOLOGICAL & PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOC JAPAN, Vol. 32, No. 7, p. 1286-1288, 2009/07
TNF superfamily member, TL1A, is a potential mucosal vaccine adjuvant, Hiroyuki Kayamuro,Yasuo Yoshioka,Yasuhiro Abe,Kazufumi Katayama,Tokuyuki Yoshida,Kohei Yamashita,Tomoaki Yoshikawa,Takachika Hiroi,Norio Itoh,Yuichi Kawai,Tadanori Mayumi,Haruhiko Kamada,Shin-ichi Tsunoda,Yasuo Tsutsumi, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC ELSEVIER SCIENCE, Vol. 384, No. 3, p. 296-300, 2009/07
Arsenic Trioxide Inhibits Human T Cell-Lymphotropic Virus-1-Induced Syncytiums by Down-Regulating gp46, Hiromi Nabeshi,Tomoaki Yoshikawa,Haruhiko Kamada,Hiroko Shibata,Toshiki Sugita,Yasuhiro Abe,Kazuya Nagano,Tetsuya Nomura,Kyoko Minowa,Takuya Yamashita,Norio Itoh,Yasuo Yoshioka,Shin-ichi Tsunoda,Yasuo Tsutsumi, BIOLOGICAL & PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOC JAPAN, Vol. 32, No. 7, p. 1286-1288, 2009/07
The augmentation of intracellular delivery of peptide therapeutics by artificial protein transduction domains, Tomoaki Yoshikawa,Toshiki Sugita,Yohei Mukai,Yasuhiro Abe,Shinsaku Nakagawa,Haruhiko Kamada,Shin-ichi Tsunoda,Yasuo Tsutsumi, BIOMATERIALS, ELSEVIER SCI LTD, Vol. 30, No. 19, p. 3318-3323, 2009/07
T細胞受容体を用いた新規ターゲティング分子の創製, 成松翔伍,吉岡靖雄,渡辺光,堤康央,向洋平,岡田直貴,中川晋作, Drug Deliv Syst, 日本DDS学会, Vol. 24, No. 3, p. 330-330, 2009/06/09
自己免疫疾患に対する有効性および安全性の向上を目指したTNFR1指向性アンタゴニストの改変, 野村鉄也,阿部康弘,吉岡靖雄,萱室裕之,向洋平,中川晋作,角田慎一,堤康央, Drug Deliv Syst, 日本DDS学会, Vol. 24, No. 3, p. 360-360, 2009/06/09
ファージ表面提示法を用いた抗腫瘍組織血管抗体の創製とその特性評価, 山下琢矢,宇都口直樹,鈴木亮,角田慎一,丸山一雄,堤康央, Drug Deliv Syst, Vol. 24, No. 3, 2009/06/09
非結晶性ナノシリカの自然免疫抑制作用に関する検討, 森重智弘,吉岡靖雄,田辺綾,堤康央,室井正志,棚元憲一,川合裕一,眞弓忠範,向洋平,岡田直貴,中川晋作, J Toxicol Sci, 日本毒性学会, Vol. 34, No. Supplement, p. S83-3009, 2009/06
各種酸化チタンの起炎性評価とそのメカニズム解析, 稲倉裕,吉岡靖雄,森重智弘,田辺綾,堤康央,河合裕一,眞弓忠範,向洋平,岡田直貴,中川晋作, J Toxicol Sci, 日本毒性学会, Vol. 34, No. Supplement, p. S84-3012, 2009/06
非結晶性シリカの粒子特性と起炎性の連関評価, 吉岡靖雄,森重智弘,田辺綾,堤康央,河合裕一,眞弓忠範,向洋平,岡田直貴,中川晋作, J Toxicol Sci, 日本毒性学会, Vol. 34, No. Supplement, p. S164-4112, 2009/06
Influence of 70 nm silica particles in mice with cisplatin or paraquat-induced toxicity, H. Nishimori,Masuo Kondoh,K. Isoda,S. Tsunoda,Y. Tsutsumi,K. Yagi, Pharmazie, Vol. 64, No. 6, p. 395-397, 2009/06
Influence of 70 nm silica particles in mice with cisplatin or paraquat-induced toxicity, H. Nishimori,M. Kondoh,K. Isoda,S. Tsunoda,Y. Tsutsumi,K. Yagi, PHARMAZIE, GOVI-VERLAG PHARMAZEUTISCHER VERLAG GMBH, Vol. 64, No. 6, p. 395-397, 2009/06
Influence of 70 nm silica particles in mice with cisplatin or paraquat-induced toxicity, H. Nishimori,M. Kondoh,K. Isoda,S. Tsunoda,Y. Tsutsumi,K. Yagi, PHARMAZIE, GOVI-VERLAG PHARMAZEUTISCHER VERLAG GMBH, Vol. 64, No. 6, p. 395-397, 2009/06
Influence of 70 nm silica particles in mice with cisplatin or paraquat-induced toxicity, H. Nishimori,M. Kondoh,K. Isoda,S. Tsunoda,Y. Tsutsumi,K. Yagi, PHARMAZIE, GOVI-VERLAG PHARMAZEUTISCHER VERLAG GMBH, Vol. 64, No. 6, p. 395-397, 2009/06
Antibody‐drug conjugate製剤の開発に適う細胞内侵入抗体の効率的創製法の確立, 吉川舞,向洋平,久保貴,吉岡靖雄,岡田直貴,堤康央,角田慎一,中川晋作, 薬剤学, (公社)日本薬剤学会, Vol. 69, No. Supplement, p. 131-131, 2009/04/30
ファージ表面提示法を用いた抗腫瘍組織血管内皮細胞抗体の創製, 山下琢矢,宇都口直樹,鈴木亮,角田慎一,堤康央,丸山一雄, 薬剤学, Vol. 69, No. Supplement, 2009/04/30
抑制性レセプターを回避し得るLIGHT変異体の創製とその機能評価, 稲倉裕,吉岡靖雄,森重智弘,堤康央,向洋平,岡田直貴,中川晋作, 日本蛋白質科学会年会プログラム・要旨集, Vol. 9th, 2009/04/24
TNFR1選択的阻害剤の開発を目指したTNFR1選択的変異体の創製とそのレセプター結合における構造‐活性相関研究, 向洋平,柴田寛子,中村照也,吉岡靖雄,阿部康弘,野村鉄也,谷合まどか,太田恒孝,池水信二,鎌田春彦,角田慎一,中川晋作,山縣ゆり子,堤康央, 日本蛋白質科学会年会プログラム・要旨集, Vol. 9th, 2009/04/24
T細胞受容体を用いた新規ターゲティング分子の創製, 成松翔伍,吉岡靖雄,渡辺光,堤康央,向洋平,岡田直貴,中川晋作, 日本蛋白質科学会年会プログラム・要旨集, Vol. 9th, 2009/04/24
TNFR1選択的阻害剤の開発を目指したTNFR1選択的変異体の創製とそのレセプター結合における構造‐活性相関研究, 向洋平,柴田寛子,中村照也,吉岡靖雄,阿部康弘,野村鉄也,谷合まどか,太田恒孝,池水信二,鎌田春彦,角田慎一,中川晋作,山縣ゆり子,堤康央, 日本蛋白質科学会年会プログラム・要旨集, Vol. 9th, 2009/04/24
活性増強型リンフォトキシンαの機能解明, 渡辺光,吉岡靖雄,堤康央,向洋平,岡田直貴,中川晋作, 日本蛋白質科学会年会プログラム・要旨集, Vol. 9th, 2009/04/24
レセプター指向性を有するリンフォトキシンαの創製と特性評価, 吉岡靖雄,渡辺光,堤康央,AHMAD Shandar,長尾知生子,池水信二,水口賢司,向洋平,岡田直貴,中川晋作, 日本蛋白質科学会年会プログラム・要旨集, Vol. 9th, 2009/04/24
Rapid isolation of intrabody candidates by using an optimized non-immune phage antibody library, K. Nagano,S. Imai,Y. Mukai,S. Nakagawa,Y. Abe,H. Kamada,Shin-Ichi Tsunoda,Y. Tsutsumi, Pharmazie, Vol. 64, No. 4, p. 238-241, 2009/04
Rapid isolation of intrabody candidates by using an optimized non-immune phage antibody library, K. Nagano,S. Imai,Y. Mukai,S. Nakagawa,Y. Abe,H. Kamada,S. Tsunoda,Y. Tsutsumi, PHARMAZIE, GOVI-VERLAG PHARMAZEUTISCHER VERLAG GMBH, Vol. 64, No. 4, p. 238-241, 2009/04
Rapid isolation of intrabody candidates by using an optimized non-immune phage antibody library, K. Nagano,S. Imai,Y. Mukai,S. Nakagawa,Y. Abe,H. Kamada,S. Tsunoda,Y. Tsutsumi, PHARMAZIE, GOVI-VERLAG PHARMAZEUTISCHER VERLAG GMBH, Vol. 64, No. 4, p. 238-241, 2009/04
Rapid isolation of intrabody candidates by using an optimized non-immune phage antibody library, K. Nagano,S. Imai,Y. Mukai,S. Nakagawa,Y. Abe,H. Kamada,S. Tsunoda,Y. Tsutsumi, PHARMAZIE, GOVI-VERLAG PHARMAZEUTISCHER VERLAG GMBH, Vol. 64, No. 4, p. 238-241, 2009/04
球状ナノシリカ粒子の急性肝傷害機構解析, 西森光,磯田勝広,近藤昌夫,角田慎一,堤康央,八木清仁, 日本薬学会年会要旨集, Vol. 129th, No. 3, 2009/03/05
球状ナノシリカ粒子の肝傷害性に対する表面荷電の影響, 長谷崎拓也,田中一成,磯田勝広,近藤昌夫,角田慎一,堤康央,八木清仁, 日本薬学会年会要旨集, Vol. 129th, No. 3, 2009/03/05
ナノシリカ粒子と化学物質の併用によるナノマテリアルの安全性評価, 西森光,長谷崎拓也,磯田勝広,近藤昌夫,角田慎一,堤康央,八木清仁, 日本薬学会年会要旨集, Vol. 129th, No. 3, 2009/03/05
ナノシリカ粒子頻回投与によるナノマテリアルの安全性評価, 西森光,磯田勝広,近藤昌夫,角田慎一,堤康央,八木清仁, 日本薬学会年会要旨集, Vol. 129th, No. 3, 2009/03/05
新規素材として期待されるナノマテリアルの自然免疫攪乱作用に関する検討, 吉岡靖雄,田辺綾,森重智弘,姚醒蕾,渡辺光,室井正志,棚元憲一,堤康央,向洋平,岡田直貴,中川晋作, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 129th, No. 3, p. 155-155, 2009/03/05
各種酸化チタンの起炎性評価及びそのメカニズム解析, 森重智弘,吉岡靖雄,田辺綾,渡辺光,姚醒蕾,堤康央,向洋平,岡田直貴,中川晋作, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 129th, No. 3, p. 180-180, 2009/03/05
TNFSF14/LIGHTによる効率的な腫瘍特異的免疫応答の惹起と抗腫瘍効果に関する検討, 稲倉裕,吉岡靖雄,森重智弘,田辺綾,渡辺光,姚醒蕾,堤康央,向洋平,岡田直貴,中川晋作, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 129th, No. 3, p. 170-170, 2009/03/05
ナノシリカの皮膚透過性と経皮リスクに関する基礎検討, 松尾一彦,免山智行,角田慎一,堤康央,向洋平,吉岡靖雄,岡田直貴,中川晋作, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 129th, No. 4, p. 286-286, 2009/03/05
I型TNF受容体選択的アンタゴニストの創出とその自己免疫疾患治療薬としての可能性, 野村鉄也,阿部康弘,吉岡靖雄,中川晋作,角田慎一,堤康央, 日本薬学会年会要旨集, Vol. 129th, No. 1, 2009/03/05
疾患プロテオミクスからバイオマーカーの創出へ―抗体プロテオミクス技術の確立とがん関連マーカーの探索―, 長野一也,今井直,中川晋作,角田慎一,堤康央, 日本薬学会年会要旨集, Vol. 129th, No. 1, 2009/03/05
The specific effect of 2-methoxyestradiol on lymphatic vascular endothelial cells, S. Imai,Y. Yoshida,T. Okamura,K. Nagano,Y. Abe,T. Yoshikawa,H. Kamada,S. Nakagawa,S. Tsunoda,Y. Tsutsumi, PHARMAZIE, GOVI-VERLAG PHARMAZEUTISCHER VERLAG GMBH, Vol. 64, No. 3, p. 214-216, 2009/03
The specific effect of 2-methoxyestradiol on lymphatic vascular endothelial cells, S. Imai,Y. Yoshida,T. Okamura,K. Nagano,Y. Abe,T. Yoshikawa,H. Kamada,S. Nakagawa,S. Tsunoda,Y. Tsutsumi, PHARMAZIE, GOVI-VERLAG PHARMAZEUTISCHER VERLAG GMBH, Vol. 64, No. 3, p. 214-216, 2009/03
Crystallization and preliminary X-ray analysis of the tumour necrosis factor alpha-tumour necrosis factor receptor type 2 complex, Yohei Mukai,Teruya Nakamura,Yasuo Yoshioka,Shin-ichi Tsunoda,Haruhiko Kamada,Shinsaku Nakagawa,Yuriko Yamagata,Yasuo Tsutsumi, ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, INT UNION CRYSTALLOGRAPHY, Vol. 65, p. 295-298, 2009/03
Influence of 70-nm silica particles in mice with cisplatin or paraquat-induced toxicity, Pharmazie, Vol. 64(6):395-7, 2009
蛋白療法の最適化に叶う創薬基盤技術の開発とその評価, Drug Delivery System, Vol. in press, 2009
PEGylated tumor necrosis factor-alpha and its muteins, Biodrug Delivery Systems, Vol. in press, 2009
ナノ粒子の細胞内取り込みと経皮浸透, ナノ材料のリスク評価と安全性対策, Vol. in press, 2009
プロテオーム解析とタンパク質DDSの設計・評価, Pharm Tech Japan, 2009
Mutant TNF-alpha, mTNF-K90R, is a novel mucosal vaccine adjuvant candidate against HIV, Pharmazie, Vol. in press, 2009
Therapeutic effect of PEGylated TNFR1-selective antagonistic mutant TNF in experimental autoimmune encephalomyelitis mice., J. Control. Release, 2009
Therapeutic effect of PEGylated TNFR1-selective antagonistic mutant TNF in experimental autoimmune encephalomyelitis mice., J Control Release, 2009
LIGHT protein suppresses tumor growth by augmentation of immune response., Immunol Lett., Vol. 2009 Dec 2;127(1):33-8., 2009
Structure-Function Relationship of Tumor Necrosis Factor (TNF) and Its Receptor Interaction Based on 3D Structural Analysis of a Fully Active TNFR1-Selective TNF Mutant, Yohei Mukai,Hiroko Shibata,Teruya Nakamura,Yasuo Yoshioka,Yasuhiro Abe,Tetsuya Nomura,Madoka Taniai,Tsunetaka Ohta,Shinji Ikemizu,Shinsaku Nakagawa,Shin-ichi Tsunoda,Haruhiko Kamada,Yuriko Yamagata,Yasuo Tsutsumi, JOURNAL OF MOLECULAR BIOLOGY, ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, Vol. 385, No. 4, p. 1221-1229, 2009/01
Influence of 70-nm silica particles in mice with cisplatin or paraquat-induced toxicity, Pharmazie, Vol. 64(6):395-7, 2009
Mutant TNF-alpha, mTNF-K90R, is a novel mucosal vaccine adjuvant candidate against HIV, Pharmazie, Vol. in press, 2009
Therapeutic effect of PEGylated TNFR1-selective antagonistic mutant TNF in experimental autoimmune encephalomyelitis mice., J. Control. Release, 2009
Comparison of the anti-tumor activity of native, secreted, and membrane-bound LIGHT in mouse tumor models., Int .Immunopharmacol, 2009
Crystallization and preliminary X-ray analysis of the tumour necrosis factor α-tumour necrosis factor receptor type 2 complex, Acta Cryst., Vol. F65(Pt 3):295-8., 2009
Structure-Function Relationship of Tumor Necrosis Factor (TNF) and Its Receptor Interaction Based on 3D Structural Analysis of a Fully Active TNFR1-Selective TNF Mutant, Yohei Mukai,Hiroko Shibata,Teruya Nakamura,Yasuo Yoshioka,Yasuhiro Abe,Tetsuya Nomura,Madoka Taniai,Tsunetaka Ohta,Shinji Ikemizu,Shinsaku Nakagawa,Shin-ichi Tsunoda,Haruhiko Kamada,Yuriko Yamagata,Yasuo Tsutsumi, JOURNAL OF MOLECULAR BIOLOGY, ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, Vol. 385, No. 4, p. 1221-1229, 2009/01
Structure-Function Relationship of Tumor Necrosis Factor (TNF) and Its Receptor Interaction Based on 3D Structural Analysis of a Fully Active TNFR1-Selective TNF Mutant, Yohei Mukai,Hiroko Shibata,Teruya Nakamura,Yasuo Yoshioka,Yasuhiro Abe,Tetsuya Nomura,Madoka Taniai,Tsunetaka Ohta,Shinji Ikemizu,Shinsaku Nakagawa,Shin-ichi Tsunoda,Haruhiko Kamada,Yuriko Yamagata,Yasuo Tsutsumi, JOURNAL OF MOLECULAR BIOLOGY, ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, Vol. 385, No. 4, p. 1221-1229, 2009/01
PEGylated tumor necrosis factor-alpha and its muteins, Biodrug Delivery Systems, Vol. in press, 2009
Mutant TNF-alpha, mTNF-K90R, is a novel mucosal vaccine adjuvant candidate against HIV, Pharmazie, Vol. in press, 2009
Therapeutic effect of PEGylated TNFR1-selective antagonistic mutant TNF in experimental autoimmune encephalomyelitis mice., J Control Release, 2009
Therapeutic effect of PEGylated TNFR1-selective antagonistic mutant TNF in experimental autoimmune encephalomyelitis mice., J. Control. Release, 2009
Structure-Function Relationship of Tumor Necrosis Factor (TNF) and Its Receptor Interaction Based on 3D Structural Analysis of a Fully Active TNFR1-Selective TNF Mutant, Yohei Mukai,Hiroko Shibata,Teruya Nakamura,Yasuo Yoshioka,Yasuhiro Abe,Tetsuya Nomura,Madoka Taniai,Tsunetaka Ohta,Shinji Ikemizu,Shinsaku Nakagawa,Shin-ichi Tsunoda,Haruhiko Kamada,Yuriko Yamagata,Yasuo Tsutsumi, JOURNAL OF MOLECULAR BIOLOGY, ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, Vol. 385, No. 4, p. 1221-1229, 2009/01
Mutant TNF-alpha, mTNF-K90R, is a novel mucosal vaccine adjuvant candidate against HIV, Pharmazie, Vol. in press, 2009
Therapeutic effect of PEGylated TNFR1-selective antagonistic mutant TNF in experimental autoimmune encephalomyelitis mice., J. Control. Release, 2009
Structure-Function Relationship of Tumor Necrosis Factor (TNF) and Its Receptor Interaction Based on 3D Structural Analysis of a Fully Active TNFR1-Selective TNF Mutant, Yohei Mukai,Hiroko Shibata,Teruya Nakamura,Yasuo Yoshioka,Yasuhiro Abe,Tetsuya Nomura,Madoka Taniai,Tsunetaka Ohta,Shinji Ikemizu,Shinsaku Nakagawa,Shin-ichi Tsunoda,Haruhiko Kamada,Yuriko Yamagata,Yasuo Tsutsumi, JOURNAL OF MOLECULAR BIOLOGY, ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, Vol. 385, No. 4, p. 1221-1229, 2009/01
Application of Nanomaterials for Drug Innovation and Their Risks, Shin-ichi Tsunoda,Yasuo Tsutsumi, YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, PHARMACEUTICAL SOC JAPAN, Vol. 128, No. 12, p. 1713-1714, 2008/12
Application of Nanomaterials for Drug Innovation and Their Risks, Shin-ichi Tsunoda,Yasuo Tsutsumi, YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, PHARMACEUTICAL SOC JAPAN, Vol. 128, No. 12, p. 1713-1714, 2008/12
ナノマテリアルの自然免疫活性化メカニズムの検討, 田辺綾,吉岡靖雄,森重智弘,角田慎一,堤康央,向洋平,岡田直貴,中川晋作, 日本バイオマテリアル学会シンポジウム予稿集, 日本バイオマテリアル学会, Vol. 2008, p. 250-250, 2008/11/17
The therapeutic effect of TNFR1-selective antagonistic mutant TNF-alpha in murine hepatitis models, Hiroko Shibata,Yasuo Yoshioka,Akiko Ohkawa,Yasuhiro Abe,Tetsuya Nomura,Yohei Mukai,Shinsaku Nakagawa,Madoka Taniai,Tsunetaka Ohta,Tadanori Mayumi,Haruhiko Kamada,Shin-ichi Tsunoda,Yasuo Tsutsumi, CYTOKINE, ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, Vol. 44, No. 2, p. 229-233, 2008/11
The therapeutic effect of TNFR1-selective antagonistic mutant TNF-alpha in murine hepatitis models, Hiroko Shibata,Yasuo Yoshioka,Akiko Ohkawa,Yasuhiro Abe,Tetsuya Nomura,Yohei Mukai,Shinsaku Nakagawa,Madoka Taniai,Tsunetaka Ohta,Tadanori Mayumi,Haruhiko Kamada,Shin-ichi Tsunoda,Yasuo Tsutsumi, CYTOKINE, ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, Vol. 44, No. 2, p. 229-233, 2008/11
Combination of two fiber-mutant adenovirus vectors, one encoding the chemokine FKN and another encoding cytokine interleukin 12, elicits notably enhanced anti-tumor responses, Jian-Qing Gao,Naoko Kanagawa,Dong-Hang Xu,Min Han,Toshiki Sugita,Yutaka Hatanaka,Yoichi Tani,Hiroyuki Mizuguchi,Yasuo Tsutsumi,Tadanori Mayumi,Naoki Okada,Shinsaku Nakagawa, CANCER IMMUNOLOGY IMMUNOTHERAPY, SPRINGER, Vol. 57, No. 11, p. 1657-1664, 2008/11
The therapeutic effect of TNFR1-selective antagonistic mutant TNF-alpha in murine hepatitis models, Hiroko Shibata,Yasuo Yoshioka,Akiko Ohkawa,Yasuhiro Abe,Tetsuya Nomura,Yohei Mukai,Shinsaku Nakagawa,Madoka Taniai,Tsunetaka Ohta,Tadanori Mayumi,Haruhiko Kamada,Shin-ichi Tsunoda,Yasuo Tsutsumi, CYTOKINE, ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, Vol. 44, No. 2, p. 229-233, 2008/11
Effect of protein properties on display efficiency using the M13 phage display system, S. Imai,Y. Mukai,T. Takeda,Y. Abe,K. Nagano,H. Kamada,S. Nakagawa,S. Tsunoda,Y. Tsutsumi, PHARMAZIE, GOVI-VERLAG PHARMAZEUTISCHER VERLAG GMBH, Vol. 63, No. 10, p. 760-764, 2008/10
Effect of protein properties on display efficiency using the M13 phage display system, S. Imai,Y. Mukai,T. Takeda,Y. Abe,K. Nagano,H. Kamada,S. Nakagawa,S. Tsunoda,Y. Tsutsumi, PHARMAZIE, GOVI-VERLAG PHARMAZEUTISCHER VERLAG GMBH, Vol. 63, No. 10, p. 760-764, 2008/10
Effect of protein properties on display efficiency using the M13 phage display system, S. Imai,Y. Mukai,T. Takeda,Y. Abe,K. Nagano,H. Kamada,S. Nakagawa,S. Tsunoda,Y. Tsutsumi, PHARMAZIE, GOVI-VERLAG PHARMAZEUTISCHER VERLAG GMBH, Vol. 63, No. 10, p. 760-764, 2008/10
Mutant TNF elicits Th2-type responses for enhanced mucosal immunity, Hiroyuki Kayamuro,Yasuo Yoshioka,Kazufumi Katayama,Haruhiko Kamada,Tetsuya Nomura,Yasuhiro Abe,Takachika Hiroi,Shin-ichi Tsunoda,Yasuo Tsutsumi, CYTOKINE, ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD, Vol. 43, No. 3, p. 309-309, 2008/09
活性増強型リンフォトキシンαの創製とその特性評価(In vitro and in vivo antitumor effects of mutant lymphotoxin-αs with enhanced bioactivities), 渡辺光,吉岡靖雄,森重智弘,角田慎一,鎌田春彦,堤康央,向洋平,岡田直貴,中川晋作, 日本癌学会総会記事, 日本癌学会, Vol. 67回, p. 314-314, 2008/09
抗体プロテオミクスによる効率的な腫瘍バイオマーカー探索とバリデーション(Antibody-based proteomics for efficient discovery and validation of tumor biomarkers), 角田慎一,長野一也,吉川友章,吉岡靖雄,中川晋作,阿部康弘,鎌田春彦,堤康央, 日本癌学会総会記事, 日本癌学会, Vol. 67回, p. 343-343, 2008/09
Ligand-independent assembly of purified soluble magic roundabout (Robo4), a tumor-specific endothelial marker, Mai Yoshikawa,Yohei Mukai,Yoshiaki Okada,Yasuo Yoshioka,Shin-ichi Tsunoda,Yasuo Tsutsumi,Naoki Okada,William C. Aird,Takefumi Doi,Shinsaku Nakagawa, PROTEIN EXPRESSION AND PURIFICATION, ACADEMIC PRESS INC ELSEVIER SCIENCE, Vol. 61, No. 1, p. 78-82, 2008/09
各種ナノマテリアルの自然免疫応答に及ぼす影響, 田辺綾,吉岡靖雄,森重智弘,角田慎一,堤康央,向洋平,岡田直貴,中川晋作, 日本免疫毒性学会講演抄録集, Vol. 15th, 2008/08/22
Organelle-targeted delivery of biological macromolecules using the protein transduction domain: Potential applications for peptide aptamer delivery into the nucleus, Tomoaki Yoshikawa,Toshiki Sugita,Yohei Mukai,Natsue Yamanada,Kazuya Nagano,Hiromi Nabeshi,Yasuo Yoshioka,Shinsaku Nakagawa,Yasuhiro Abe,Haruhiko Kamada,Shin-ichi Tsunoda,Yasuo Tsutsumi, JOURNAL OF MOLECULAR BIOLOGY, ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD, Vol. 380, No. 5, p. 777-782, 2008/07
アンタゴニスト活性を有するI型受容体指向性TNF変異体の評価:関節リウマチモデルに対する治療効果および安全性の検討, 野村鉄也,吉岡靖雄,柴田寛子,阿部康弘,蓑輪恭子,萱室裕之,萱室裕之,中川晋作,鎌田春彦,角田慎一,堤康央, Drug Deliv Syst, Vol. 23, No. 3, 2008/06/06
ナノマテリアルの細胞内局在性および細胞毒性について電子顕微鏡による検討, 今澤孝喜,西森光,角田慎一,吉川友章,鍋師裕美,磯田勝広,近藤昌夫,八木清仁,堤康央, J Toxicol Sci, Vol. 33, No. Supplement, 2008/06
Simple and highly sensitive assay system for TNFR2-mediated soluble- and transmembrane-TNF activity, Yasuhiro Abe,Tomoaki Yoshikawa,Haruhiko Kamada,Hiroko Shibata,Tetsuya Nomura,Kyoko Minowa,Hiroyuki Kayamuro,Kazufumi Katayama,Hiroyuki Miyoshi,Yohei Mukai,Asuo Yoshioka,Shinsaku Nakagawa,Shin-ichi Tsunoda,Yasuo Tsutsumi, JOURNAL OF IMMUNOLOGICAL METHODS, ELSEVIER SCIENCE BV, Vol. 335, No. 1-2, p. 71-78, 2008/06
ファージ表面提示法を用いた活性増強型リンフォトキシンαの創製とその特性評価, 渡辺光,吉岡靖雄,森重智弘,鎌田春彦,向洋平,角田慎一,堤康央,岡田直貴,中川晋作, 日本蛋白質科学会年会プログラム・要旨集, Vol. 8th, 2008/05/23
ファージ表面提示法を用いた抗腫瘍組織血管抗体の創製, 山下琢矢,宇都口直樹,鈴木亮,長野一也,角田慎一,堤康央,丸山一雄, 遺伝子・デリバリー研究会シンポジウム要旨集, Vol. 8th, 2008/05/09
Domain mapping of a claudin-4 modulator, the C-terminal region of C-terminal fragment of Clostridium perfringens enterotoxin, by site-directed mutagenesis, Azusa Takahashi,Eriko Komiya,Hideki Kakutani,Takeshi Yoshida,Makiko Fujii,Yasuhiko Horiguchi,Hiroyuki Mizuquchi,Yasuo Tsutsumi,Shin-Ichi Tsunoda,Naoya Koizumi,Katsuhiro Isoda,Kiyohito Yagi,Yoshiteru Watanabe,Masuo Kondoh, BIOCHEMICAL PHARMACOLOGY, PERGAMON-ELSEVIER SCIENCE LTD, Vol. 75, No. 8, p. 1639-1648, 2008/04
ナノシリカの急性肝毒性と粒子径の相関, 西森光,磯田勝広,近藤昌夫,今澤孝喜,角田慎一,堤康央,八木清仁, 日本薬学会年会要旨集, Vol. 128th, No. 3, 2008/03/05
アンタゴニスト活性を有するI型受容体指向性TNF変異体の評価(1):関節リウマチモデルに対する治療効果の検討, 野村鉄也,吉岡靖雄,柴田寛子,阿部康弘,蓑輪恭子,萱室裕之,中川晋作,山本昌,鎌田春彦,角田慎一,堤康央, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 128th, No. 3, p. 9-9, 2008/03/05
免疫制御技術の開発に向けた制御性T細胞の抗体プロテオミクス研究, 長野一也,吉川友章,杉田敏樹,今井直,鍋師裕美,向洋平,中川晋作,鎌田春彦,角田慎一,堤康央, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 128th, No. 3, p. 106-106, 2008/03/05
新規Protein Transduction Domain peptideの細胞内DDSキャリアーとしての特性解析, 杉田敏樹,吉川友章,長野一也,鍋師裕美,向洋平,中川晋作,鎌田春彦,角田慎一,堤康央, 日本薬学会年会要旨集, Vol. 128th, No. 4, 2008/03/05
プロテオミクス創薬の実現に叶う機能性人工蛋白質の迅速創出技術の開発, 阿部康弘,向洋平,角田慎一,中川晋作,堤康央, 日本薬学会年会要旨集, Vol. 128th, No. 1, 2008/03/05
疾患関連蛋白質の同定およびこれらに対する抗体を一挙かつ短期間で網羅的作製できる抗体プロテオミクスの確立, 今井直,角田慎一,中川晋作,堤康央, 日本薬学会年会要旨集, Vol. 128th, No. 1, 2008/03/05
香粧品材料としてのナノマテリアルの経皮リスクに関する基礎検討, 亀井数正,向洋平,小島拓記,吉川舞,角田慎一,堤康央,吉岡靖雄,岡田直貴,中川晋作, 日本薬学会年会要旨集, Vol. 128th, No. 4, 2008/03/05
抗体プロテオミクスによるリンパ管新生関連分子の探索と機能評価に向けて, 吉田康伸,今井直,杉田敏樹,阿部康弘,萱室裕之,長野一也,鍋師裕美,野村鉄也,小泉桂一,吉川友章,鎌田春彦,角田慎一,堤康央, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 128年会, No. 3, p. 106-106, 2008/03
Comparative study on transduction and toxicity of protein transduction domains, T. Sugita,T. Yoshikawa,Y. Mukai,N. Yamanada,S. Imai,K. Nagano,Y. Yoshida,H. Shibata,Y. Yoshioka,S. Nakagawa,H. Kamada,S-i Tsunoda,Y. Tsutsumi, BRITISH JOURNAL OF PHARMACOLOGY, NATURE PUBLISHING GROUP, Vol. 153, No. 6, p. 1143-1152, 2008/03
P-062 Evaluation of genotoxic risk and oxidative DNA damage in human keratinocytes exposed to amorphous nano-silica(Poster Session), Matsuyama Keigo,Yoshikawa Tomoaki,Nabeshi Hiromi,Nakazato Yasutaro,Arimori Akihiro,Isobe Masaaki,Abe Yasuhiro,Kamada Haruhiko,Itoh Norio,Tsunoda Shin-ichi,Tsutsumi Yasuo, No. 37, p. 137-137, 2008
P-064 Influence of physicochemical properties of nano-silica particles on in vivo biologic behavior (2)(Poster Session), Nakazato Yasutaro,Yoshikawa Tomoaki,Nabeshi Hiromi,Matsuyama Keigo,Arimori Akihiro,Isobe Masaaki,Abe Yasuhiro,Kamada Haruhiko,Itoh Norio,Tsunoda Shin-ichi,Tsutsumi Yasuo, No. 37, p. 138-138, 2008
P-063 Influence of physicochemical property of nano-silicas on in vivo biological behavior (1)(Poster Session), Nabeshi Hiromi,Yoshikawa Tomoaki,Nakazato Yasutaro,Matsuyama Keigo,Arimori Akihiro,Isobe Masaaki,Imazawa Takayoshi,Abe Yasuhiro,Kamada Haruhiko,Itoh Norio,Tsunoda Shin-ichi,Tsutsumi Yasuo, No. 37, p. 138-138, 2008
P-060 / O-06 Basic examination of carbon nanotube genotoxicity(Poster Session), Yamashita Kohei,Yoshioka Yasuo,Kayamuro Hiroyuki,Yoshida Tokuyuki,Higashisaka Kazuma,Nakanishi Ryosuke,Abe Yasuhiro,Kamada Haruhiko,Itoh Norio,Tsunoda Shin-ichi,Tsutsumi Yasuo, No. 37, p. 136-136, 2008
P-130 Basic examination of immunotoxicity of urban aerosols(Poster Session), Yoshida Tokuyuki,Yoshioka Yasuo,Kayamuro Hiroyuki,Yamashita Kouhei,Higashisaka Kazuma,Nakanishi Ryousuke,Abe Yasuhiro,Kamada Haruhiko,Itoh Norio,Tsunoda Shin-ichi,Tsutsumi Yasuo, No. 37, p. 171-171, 2008
Examination according to an electron microscope about the intracellular localization and cytotoxicity of nano material, Imazawa Takayoshi,Nishimori Hikaru,Tsunoda Shinichi,Yoshikawa Tomoaki,Nabeshi Hiromi,Isoda Katsuhiro,Kondoh Masuo,Yagi Kiyohito,Tsutsumi Yasuo, Annual Meeting of the Japanese Society of Toxicology, The Japanese Society of Toxicology, Vol. 35, No. 0, p. 104-104, 2008
ナノシリカの自然免疫応答に及ぼす影響, 吉岡靖雄,田辺綾,堤康央,向洋平,岡田直貴,中川晋作, 生化学, 2008
T細胞受容体を用いた新規ターゲティング分子の創製に関する基礎的検討, 成松翔伍,吉岡靖雄,堤康央,向洋平,岡田直貴,中川晋作, 生化学, 2008
ナノマテリアルのオートファジー誘導に関する検討, 田辺綾,吉岡靖雄,堤康央,向洋平,岡田直貴,中川晋作, 生化学, 2008
Creation of receptor-selective TNFs with agonistic activity, Shibata H,Kamada H,Yoshioka Y,Ohkawa A,Minowa K,Mukai Y,Abe Y,Taniai M,Nomura T,Kayamuro H,Nabeshi H,Sugita T,Imai S,Nagano K,Yoshikawa T,Fujita T,Nakagawa S,Yamamoto A,Ohta T,Hayakawa T,Mayumi T,Vandeenabeele P,Aggarwal BB,Tsunoda S,Tsutsumi Y, J. Biol. Chem., Vol. 283, No. 2, p. 998-1007, 2008
Improved cytosolic translocation and tumor-killing activity of Tat-shepherdin conjugates mediated by co-treatment with Tat-fused endosome-disruptive HA2 peptide, Toshiki Sugita,Tomoaki Yoshikawa,Yohei Muka,Natsue Yamanada,Imai Sunao,Kazuya Nagano,Yasunobu Yoshida,Hiroko Shibata,Yasuo Yoshioka,Shinsaku Nakagawa,Haruhiko Kamada,Shin-Ichi Tsunoda,Yasuo Tsutsumi, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC ELSEVIER SCIENCE, Vol. 363, No. 4, p. 1027-1032, 2007/11
血栓性疾患の機能解明・治療を目指したファージ抗体ライブラリの構築, 長野一也,今井直,杉田敏樹,向洋平,吉川友章,吉田康伸,中川晋作,鎌田春彦,角田慎一,堤康央, 日本血栓止血学会誌, (一社)日本血栓止血学会, Vol. 18, No. 5, p. 514-514, 2007/10/01
血栓性疾患の機能解明・治療を目指した新規抗体単離システムの構築, 今井直,長野一也,杉田敏樹,吉田康伸,向洋平,吉川友章,中川晋作,鎌田春彦,角田慎一,堤康央, 日本血栓止血学会誌, (一社)日本血栓止血学会, Vol. 18, No. 5, p. 514-514, 2007/10/01
TNFレセプター選択的阻害剤開発を目指したTNFR2‐TNF複合体のX線結晶構造解析, 向洋平,阿部康弘,鎌田春彦,角田慎一,中川晋作,堤康央, 日本血栓止血学会誌, (一社)日本血栓止血学会, Vol. 18, No. 5, p. 516-516, 2007/10/01
血管機能制御を目指した効率的な細胞内高分子導入技術の開発, 吉川友章,杉田敏樹,向洋平,今井直,長野一也,吉田康伸,中川晋作,鎌田春彦,角田慎一,堤康央, 日本血栓止血学会誌, (一社)日本血栓止血学会, Vol. 18, No. 5, p. 526-526, 2007/10/01
新規細胞内移行ペプチドの創出と血管機能制御技術としての展開, 吉田康伸,吉川友章,杉田敏樹,向洋平,今井直,長野一也,中川晋作,鎌田春彦,角田慎一,堤康央, 日本血栓止血学会誌, (一社)日本血栓止血学会, Vol. 18, No. 5, p. 527-527, 2007/10/01
血管機能制御を目指した効率的な細胞内高分子導入技術の開発‐2, 杉田敏樹,吉川友章,向洋平,今井直,長野一也,吉田康伸,中川晋作,鎌田春彦,角田慎一,堤康央, 日本血栓止血学会誌, (一社)日本血栓止血学会, Vol. 18, No. 5, p. 527-527, 2007/10/01
ファージ抗体ライブラリと2D-DIGE法を用いた腫瘍関連蛋白質に対するモノクローナル抗体の迅速単離法(A method for rapid preparation of antibodies to tumor-related proteins by the combination of phage library and 2D-DIGE), 角田慎一,向洋平,吉川友章,鎌田春彦,中川晋作,堤康央, 日本癌学会総会記事, 日本癌学会, Vol. 66回, p. 173-173, 2007/08
細胞膜透過性TATペプチドと膜融合性HA2ペプチドを活用した核内高分子送達法の開発(Delivery of NLS conjugated bioactive proteins into nucleus using cell-permeable and membrane-disruptive TAT-HA2 peptide), 吉川友章,向洋平,中川晋作,鎌田春彦,角田慎一,堤康央, 日本癌学会総会記事, 日本癌学会, Vol. 66回, p. 532-532, 2007/08
Creation of a novel cell penetrating peptide, using a random 18mer peptides library, T. Nomura,M. Kawamura,H. Shibata,Y. Abe,A. Ohkawa,Y. Muka,T. Sugita,S. Imai,K. Nagano,T. Okamoto,Y. Tsutsumi,H. Kamada,S. Nakagawa,S. Tsunoda, PHARMAZIE, GOVI-VERLAG PHARMAZEUTISCHER VERLAG GMBH, Vol. 62, No. 8, p. 569-573, 2007/08
Role of amino acid residue 90 in bioactivity and receptor binding capacity of tumor necrosis factor mutants, Hiroko Shibata,Haruhiko Kamada,Kyoko Kobayashi-Nishibata,Yasuo Yoshioka,Toshihide Nishibata,Yasuhiro Abe,Tetsuya Nomura,Hiromi Nabeshi,Kyoko Minowa,Yohei Mukai,Shinsaku Nakagawa,Tadanori Mayumi,Shin-ichi Tsunoda,Yasuo Tsutsumi, BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, ELSEVIER SCIENCE BV, Vol. 1774, No. 8, p. 1029-1035, 2007/08
Creation of TNF receptor1-selective mutant TNF using phage display system, Kyoko Minowa,Yoshioka Yasuo,Yasuhiro Abe,Tetsuya Nomura,Hiromi Nabeshi,Hiroyuki Kayamuro,Hiroko Shibata,Takuya Fujita,Akira Yamamoto,Shin-Ichi Tsunoda,Haruhiko Kamada,Yasuo Tsutsumi, CYTOKINE, ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD, Vol. 39, No. 1, p. 28-28, 2007/07
The combination of IFN-alpha 2 and IFN-alpha 8 exhibits synergistic antiproliferative activity on renal cell carcinoma (RCC) cell lines through increased binding affinity for IFNAR-2, Tadao Tanimoto,Shigeto Yamamoto,Madoka Taniai,Mutsuko Taniguchi,Harumi Ariyasu,Chie Ushio,Miho Aga,Yohei Mukai,Yasuo Tsutsumi,Toshio Ariyasu,Tsunetaka Ohta,Shigeharu Fukuda, JOURNAL OF INTERFERON AND CYTOKINE RESEARCH, MARY ANN LIEBERT INC, Vol. 27, No. 6, p. 517-523, 2007/06
抗腫瘍活性に優れたTNFレセプター指向性変異体の創製, 野村鉄也,柴田寛子,阿部康弘,蓑輪恭子,鍋師裕美,中川晋作,吉岡靖雄,角田慎一,鎌田春彦,堤康央, Drug Deliv Syst, 日本DDS学会, Vol. 22, No. 3, p. 317-317, 2007/05/30
細胞内への薬物送達を志向したペプチドキャリアーの特性評価, 角田慎一,山名田夏枝,杉田敏樹,長野一也,今井直,向洋平,吉川友章,中川晋作,今澤孝善,鎌田春彦,堤康央, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 127th, No. 3, p. 126-126, 2007/03/05
抗腫瘍活性・リンパ組織形成能に優れた機能化LIGHT変異体創製に関する基礎的検討, 森重智弘,吉岡靖雄,渡辺光,鎌田春彦,向洋平,角田慎一,岡田直貴,堤康央,中川晋作, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 127th, No. 3, p. 130-130, 2007/03/05
人工リンパ組織構築を目指したリジン欠損リンフォトキシン変異体創製に関する基礎的検討, 渡辺光,吉岡靖雄,森重智弘,鎌田春彦,向洋平,角田慎一,岡田直貴,堤康央,中川晋作, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 127th, No. 3, p. 131-131, 2007/03/05
TNFレセプターの機能解析を目指したTNFR2指向性変異体の作製, 野村鉄也,柴田寛子,阿部康弘,蓑輪恭子,鍋師裕美,吉岡靖雄,中川晋作,鎌田春彦,角田慎一,堤康央, 日本薬学会年会要旨集, Vol. 127th, No. 2, 2007/03/05
TNFR1指向性変異体を目指した新規ファージライブラリの作製, 鎌田春彦,柴田寛子,阿部康弘,野村鉄也,鍋師裕美,蓑輪恭子,中川晋作,吉岡靖雄,角田慎一,堤康央, 日本薬学会年会要旨集, Vol. 127th, No. 2, 2007/03/05
ファージ抗体ライブラリを用いた疾患関連蛋白質抗体の迅速単離法の確立, 今井直,長野一也,杉田敏樹,山名田夏枝,向洋平,吉川友章,中川晋作,鎌田春彦,角田慎一,堤康央, 日本薬学会年会要旨集, Vol. 127th, No. 2, 2007/03/05
アンタゴニスト活性を有したTNF変異体の創製に関する基礎的検討―1, 柴田寛子,蓑輪恭子,阿部康弘,野村鉄也,鍋師裕美,吉岡靖雄,中川晋作,鎌田春彦,角田慎一,堤康央, 日本薬学会年会要旨集, Vol. 127th, No. 2, 2007/03/05
ファージ抗体ライブラリを用いたイントラボディの効率的創製法の開発, 長野一也,今井直,杉田敏樹,山名田夏枝,向洋平,吉川友章,中川晋作,鎌田春彦,角田慎一,堤康央, 日本薬学会年会要旨集, Vol. 127th, No. 2, 2007/03/05
特異的結合能を有する構造変異体のスクリーニング条件の最適化, 阿部康弘,柴田寛子,野村鉄也,鍋師裕美,蓑輪恭子,鎌田春彦,中川晋作,吉岡靖雄,角田慎一,堤康央, 日本薬学会年会要旨集, Vol. 127th, No. 2, 2007/03/05
細胞内薬物療法の最適化を目指した細胞内移行性ペプチド(PTD)の特性評価, 杉田敏樹,山名田夏枝,向洋平,吉川友章,中川晋作,鎌田春彦,角田慎一,堤康央, 日本薬学会年会要旨集, Vol. 127th, No. 1, 2007/03/05
TNFR1特異的アンタゴニストTNF;3‐1CのX線結晶構造解析, 向洋平,中村照也,柴田寛子,阿部康弘,鎌田春彦,角田慎一,中川晋作,山懸ゆり子,堤康央, 日本薬学会年会要旨集, Vol. 127th, No. 2, 2007/03/05
Cotransduction of CCL27 gene can improve the efficacy and safety of IL-12 gene therapy for cancer, J-Q Gao,N. Kanagawa,Y. Motomura,T. Yanagawa,T. Sugita,Y. Hatanaka,Y. Tani,H. Mizuguchi,Y. Tsutsumi,T. Mayumi,N. Okada,S. Nakagawa, GENE THERAPY, NATURE PUBLISHING GROUP, Vol. 14, No. 6, p. 491-502, 2007/03
Creation of novel cell-penetrating peptides for intracellular drug delivery using systematic phage display technology originated from tat transduction domain, Haruhiko Kamada,Takayuki Okamota,Maki Kawamura,Hiroko Shibata,Yasuhiro Abe,Akiko Ohkawa,Tetsuya Nomura,Masaki Sato,Yohei Mukai,Toshiki Sugita,Sunao Imai,Kazuya Nagano,Yasuo Tsutsumi,Shinsaku Nakagawa,Tadanori Mayumi,Shin-ichi Tsunoda, BIOLOGICAL & PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOC JAPAN, Vol. 30, No. 2, p. 218-223, 2007/02
Creation of TNFR2-selective mutants using phage display technique, Abe Yasuhiro,Tsutsumi Yasuo,Nomura Tetsuya,Nabeshi Hiromi,Kayamuro Kyoko,Minowa Kyoko,Kamada Haruhiko,Nakagawa Shinsaku,Yoshioka Yasuo,Tsunoda Shin-ichi, Abstracts for Annual Meeting of Japanese Proteomics Society, Japanese Proteomics Society (Japan Human Proteome Organisation), Vol. 2007, No. 0, p. 153-153, 2007
Development of rapid isolation of antibody specific for disease-related proteins toward proteomics drug discovery, Imai Sunao,Tsutsumi Yasuo,Nagano Kazuya,Sugita Toshiki,Yoshida Yasunobu,Mukai Yohei,Yoshikawa Tomoaki,Kamada Haruhiko,Tsunoda Shin-ichi,Nakagawa Shinsaku, Abstracts for Annual Meeting of Japanese Proteomics Society, Japanese Proteomics Society (Japan Human Proteome Organisation), Vol. 2007, No. 0, p. 151-151, 2007
全身投与による癌遺伝子治療の最適化を目指した高分子バイオコンジュゲート化アデノウイルスベクターの創製, 衛藤佑介,吉岡靖雄,森重智弘,姚醒蕾,倉知慎之輔,水口裕之,堤康央,向洋平,岡田直貴,中川晋作, 遺伝子・デリバリー研究会シンポジウム要旨集, Vol. 7th, 2007
血管新生に関わるRobo4蛋白質の発現と精製, 吉川舞,向洋平,岡田欣晃,土井健史,吉岡靖雄,岡田直貴,堤康央,角田慎一,中川晋作, 生化学, 2007
Systemic Administration of PEGylated Adenovirus Vector Enhances Vector Accumulation and Gene Expression in Tumors and Improves Anti-tumor Effects in Cytokine Gene Therapy, Gao J.Q,Eto Y,Yoshioka Y,Sekiguchi F,Kurachi S,Morishige T,Yao X,Watanabe H,Asavatanabodee R,Sakurai F,Mizuguchi H,Okada Y,Mukai Y,Tsutsumi Y,Mayumi T,Okada N,Nakagawa S, J. Control. Release, Vol. 122, No. 1, p. 102-110, 2007
A strategy for efficient cross-presentation of CTL-epitope peptides leading to enhanced induction of in vivo tumor immunity, Akira Hayashi,Hisashi Wakita,Tomoaki Yoshikawa,Tsuyoshi Nakanishi,Yasuo Tsutsumi,Tadanori Mayumi,Yohei Mukai,Yasuo Yoshioka,Naoki Okada,Shinsaku Nakagawa, JOURNAL OF CONTROLLED RELEASE, ELSEVIER SCIENCE BV, Vol. 117, No. 1, p. 11-19, 2007/01
細胞内薬物導入キャリアとしての細胞内移行ペプチドの応用技術., 絵で見てわかるナノDDS, 向洋平,堤康央,中川晋作, 遺伝子医学MOOK別冊, p. 184-190, 2007
Development of new anti-TNF therapy, Kamada H,Shibata H,Tsutsumi Y, Inflammation and Regeneration, Vol. 27, No. 5, p. 512-515, 2007
Optimization of anti-tumor necrosis factor-alpha single chain Fv displayed on phages for creation of functional antibodies, Y. Mukai,T. Okamoto,M. Kawamura,H. Shibata,T. Sugita,S. Imai,Y. Abe,K. Nagano,T. Nomura,H. Kamada,Y. Tsutsumi,T. Mayumi,S. Nakagawa,S. Tsunoda, PHARMAZIE, GOVI-VERLAG PHARMAZEUTISCHER VERLAG GMBH, Vol. 61, No. 10, p. 889-890, 2006/10
Creation of novel protein transduction domain (PTD) mutants by a phage display-based high-throughput screening system, Yohei Mukai,Toshiki Sugita,Tomoko Yamato,Natsue Yamanada,Hiroko Shibata,Sunao Imai,Yasuhiro Abe,Kazuya Nagano,Tetsuya Nomura,Yasuo Tsutsumi,Haruhiko Kamada,Shinsaku Nakagawa,Shin-ichi Tsunoda, BIOLOGICAL & PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOC JAPAN, Vol. 29, No. 8, p. 1570-1574, 2006/08
Quality enhancement of the non-immune phage scFv library to isolate effective antibodies, Sunao Imai,Yohei Mukai,Kazuya Nagano,Hiroko Shibata,Toshiki Sugita,Yasuhiro Abe,Tetsuya Nomura,Yasuo Tsutsumi,Haruhiko Kamada,Shinsaku Nakagawa,Shin-ichi Tsunoda, BIOLOGICAL & PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOC JAPAN, Vol. 29, No. 7, p. 1325-1330, 2006/07
A novel method for construction of gene fragment library to searching epitopes, Maki Kawamura,Hiroko Shibata,Haruhiko Kamada,Takayuki Okamoto,Yohei Mukai,Toshiki Sugita,Yasuhiro Abe,Sunao Imai,Tetsuya Nomura,Kazuya Nagano,Tadanori Mayumi,Shinsaku Nakagawa,Yasuo Tsutsumi,Shin-ich Tsunoda, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC ELSEVIER SCIENCE, Vol. 346, No. 1, p. 198-204, 2006/07
A novel method for construction of gene fragment library to searching epitopes, Maki Kawamura,Hiroko Shibata,Haruhiko Kamada,Takayuki Okamoto,Yohei Mukai,Toshiki Sugita,Yasuhiro Abe,Sunao Imai,Tetsuya Nomura,Kazuya Nagano,Tadanori Mayumi,Shinsaku Nakagawa,Yasuo Tsutsumi,Shin-ich Tsunoda, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC ELSEVIER SCIENCE, Vol. 346, No. 1, p. 198-204, 2006/07
Quality enhancement of the non-immune phage scFv library to isolate effective antibodies, Sunao Imai,Yohei Mukai,Kazuya Nagano,Hiroko Shibata,Toshiki Sugita,Yasuhiro Abe,Tetsuya Nomura,Yasuo Tsutsumi,Haruhiko Kamada,Shinsaku Nakagawa,Shin-ichi Tsunoda, BIOLOGICAL & PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOC JAPAN, Vol. 29, No. 7, p. 1325-1330, 2006/07
TNFR1へのターゲティング能を付与した構造変異TNF‐αの創製, 野村鉄也,柴田寛子,阿部康弘,大川亜紀子,岡田直貴,中川晋作,真弓忠範,角田慎一,堤康央,鎌田春彦, Drug Deliv Syst, 日本DDS学会, Vol. 21, No. 3, p. 297-297, 2006/06/20
非免疫ファージ抗体ライブラリを用いた疾患関連蛋白質抗体の迅速単離法の確立, 長野一也,向洋平,今井直,杉田敏樹,山名田夏枝,中川晋作,真弓忠範,鎌田春彦,角田慎一,堤康央, Drug Deliv Syst, 日本DDS学会, Vol. 21, No. 3, p. 299-299, 2006/06/20
Promotion of optimized protein therapy by bioconjugation as a polymeric DDS, Yasuhiro Abe,Hiroko Shibata,Haruhiko Kamada,Shin-Ichi Tsunoda,Yasuo Tsutsumi,Shinsaku Nakagawa, Anti-Cancer Agents in Medicinal Chemistry, Vol. 6, No. 3, p. 251-258, 2006/05
Promotion of optimized protein therapy by bioconjugation as a polymeric DDS, Yasuhiro Abe,Hiroko Shibata,Haruhiko Kamada,Shin-Ichi Tsunoda,Yasuo Tsutsumi,Shinsaku Nakagawa, Anti-Cancer Agents in Medicinal Chemistry, Vol. 6, No. 3, p. 251-258, 2006/05
Transductional and transcriptional tumor-targeting using adenoviral vector with PEGylation and TERT promoter on systemic administration into tumor-bearing mice, Yusuke Eto,Shinnosuke Kurachi,Tomohiro Morishige,Xinglei Yao,Hikaru Watanabe,Yuka Okada,Hiroyuki Mizuguchi,Yasuo Tsutsumi,Naoki Okada,Shinsaku Nakagawa, CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, Vol. 66, No. 8, 2006/04
抗原提示細胞への抗原蛋白質デリバリーにおけるγ‐PGAナノ粒子の有用性, 小田淳史,吉川友章,丹羽貴子,松尾一彦,萱室裕之,堤康央,赤木隆美,明石満,岡田直貴,中川晋作, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 126th, No. 2, p. 128-128, 2006/03/06
pIII,pVIII提示型ファージ表面提示法の特性評価, 向洋平,竹田武弘,杉田敏樹,今井直,山名田夏枝,長野一也,柴田寛子,鎌田春彦,中川晋作,真弓忠範,角田慎一,堤康央, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 126th, No. 2, p. 135-135, 2006/03/06
細胞内薬物導入キャリアとしての細胞内移行性ペプチド(PTD)の機能評価, 山名田夏枝,向洋平,杉田敏樹,今井直,長野一也,柴田寛子,鎌田春彦,中川晋作,真弓忠範,角田慎一,堤康央, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 126th, No. 2, p. 135-135, 2006/03/06
高親和性抗体の迅速単離を目指した非免疫scFvファージライブラリの構築, 今井直,向洋平,長野一也,杉田敏樹,山名田夏枝,柴田寛子,中川晋作,真弓忠範,鎌田春彦,角田慎一,堤康央, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 126th, No. 2, p. 134-134, 2006/03/06
in vitro抗体創製法としての改良型非免疫ファージライブラリの有用性評価, 長野一也,向洋平,今井直,杉田敏樹,山名田夏枝,柴田寛子,中川晋作,真弓忠範,鎌田春彦,角田慎一,堤康央, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 126th, No. 2, p. 134-134, 2006/03/06
細胞内ターゲティング療法を目指した新規細胞内移行性ペプチドの創製, 杉田敏樹,向洋平,岡本貴之,山名田夏枝,今井直,長野一也,柴田寛子,鎌田春彦,中川晋作,真弓忠範,角田慎一,堤康央, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 126th, No. 2, p. 135-135, 2006/03/06
ファージ表面提示法を駆使したTNFR1指向性変異体の作製―2―パンニング条件の最適化と構造変異TNF‐αのレセプター選択性の評価―, 阿部康弘,柴田寛子,大川亜紀子,野村鉄也,佐藤雅紀,向洋平,杉田敏樹,中川晋作,真弓忠範,角田慎一,鎌田春彦,堤康央, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 126th, No. 2, p. 135-135, 2006/03/06
ファージ表面提示法を駆使したTNFR1指向性変異体の作製―3―構造変異TNF‐α精製たんぱく質の作製とその機能評価―, 野村鉄也,柴田寛子,阿部康弘,大川亜紀子,佐藤雅紀,向洋平,杉田敏樹,中川晋作,真弓忠範,角田慎一,鎌田春彦,堤康央, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 126th, No. 2, p. 135-135, 2006/03/06
ファージ表面提示法を駆使したTNFR1指向性変異体の作製―1―TNF構造変異体作製のためのファージライブラリの作製―, 大川亜紀子,柴田寛子,阿部康弘,野村鉄也,佐藤雅紀,向洋平,杉田敏樹,中川晋作,真弓忠範,角田慎一,鎌田春彦,堤康央, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 126th, No. 2, p. 135-135, 2006/03/06
ヒトプラスミノーゲンクリングル5関連ペプチドの合成, 前田光子,望月麻友美,武林久瑠美,吉岡靖雄,喜田進也,北条恵子,堤康央,中川晋作,真弓忠範,野水基義,川崎紘一, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 126th, No. 3, p. 45-45, 2006/03/06
アポトーシス抵抗性樹状細胞の創製と抗腫ようワクチン機能の評価, 丹羽貴子,吉川友章,後藤美千代,水口裕之,堤康央,岡田直貴,中川晋作, 日本薬学会年会要旨集, Vol. 126th, No. 2, 2006/03/06
IL‐12発現ベクターを投与した腫よう組織における免疫イベントの解析, 金川尚子,吉川友章,畑中豊,谷洋一,水口裕之,堤康央,岡田直貴,中川晋作, 日本薬学会年会要旨集, Vol. 126th, No. 2, 2006/03/06
ポリエチレングリコール修飾アデノウイルスベクターを用いた腫よう標的化自殺遺伝子治療の開発, 醒らいよう,衛藤佑介,倉知慎之輔,森重智弘,渡辺光,岡田裕香,水口裕之,堤康央,岡田直貴,中川晋作, 日本薬学会年会要旨集, Vol. 126th, No. 2, 2006/03/06
抗原蛋白質を内包したγ‐PGAナノ粒子の特性評価と抗腫ようワクチンキャリアーへの応用, 吉川友章,小田淳史,丹羽貴子,松尾一彦,萱室裕之,堤康央,赤木隆美,明石満,岡田直貴,中川晋作, 日本薬学会年会要旨集, Vol. 126th, No. 2, 2006/03/06
Enhanced anti-tumor responses induced by the combination of a couple of stimulators: IL-12 and CCL27, T Sugita,JQ Gao,N Kanagawa,Y Motomura,T Nakayama,O Yoshie,Y Hatanaka,Y Tani,H Mizuguchi,Y Tsutsumi,S Nakagawa, JOURNAL OF GENE MEDICINE, JOHN WILEY & SONS LTD, Vol. 8, No. 3, p. 397-397, 2006/03
受容体への選択的ターゲティング能を有した機能性人工蛋白質の創出システムの開発, 柴田寛子,大川亜紀子,阿部康弘,野村鉄也,向洋平,杉田敏樹,中川晋作,真弓忠範,角田慎一,鎌田春彦,堤康央, 薬剤学, (公社)日本薬剤学会, Vol. 66, No. Supplement, p. 106-106, 2006/02/24
腫よう標的化を目指した改良型アデノウイルスベクターの創製, 森重智弘,衛藤佑介,倉知慎之輔,よう醒らい,渡辺光,岡田裕香,水口裕之,堤康央,岡田直貴,中川晋作, 薬剤学, Vol. 66, No. Supplement, p. 117-117, 2006/02/24
Creation of receptor selective mutants for understanding structure-activity relationships, Abe Yasuhiro,Kamada Haruhiko,Shibata Hiroko,Nomura Tetsuya,Nabeshi Hiromi,Minowa Kyoko,Tsunoda Shin-ichi,Tsutsumi yasuo,Nakagawa Shinsaku, Abstracts for Annual Meeting of Japanese Proteomics Society, Japanese Proteomics Society (Japan Human Proteome Organisation), Vol. 2006, No. 0, p. 78-78, 2006
Creation of structural mutant protein using phage display system, Kamada Haruhiko,Abe Yasuhiro,Shibata Hiroko,Nomura Tetsuya,Nabeshi Hiromi,Minowa Kyoko,Nakagawa Shinsaku,Tsunoda Shin-ichi,Tsutsumi Yasuo, Abstracts for Annual Meeting of Japanese Proteomics Society, Japanese Proteomics Society (Japan Human Proteome Organisation), Vol. 2006, No. 0, p. 96-96, 2006
The establishment of rapid isolation methods of antibody to disease related proteins using phage antibody library, Imai Sunao,Mukai Yohei,Nagano kazuya,Sugita Toshiki,Yamanada Natsue,Kamada Haruhiko,Tsunoda Shin-ichi,Tsutsumi Yasuo,Nakagawa Shinsaku, Abstracts for Annual Meeting of Japanese Proteomics Society, Japanese Proteomics Society (Japan Human Proteome Organisation), Vol. 2006, No. 0, p. 98-98, 2006
Vaccine efficacy of fusogenic liposomes containing tumor cell-lysate against murine B16BL6 melanoma, T Yoshikawa,N Okada,M Tsujino,JQ Gao,A Hayashi,Y Tsutsumi,T Mayumi,A Yamamoto,S Nakagawa, BIOLOGICAL & PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOC JAPAN, Vol. 29, No. 1, p. 100-104, 2006/01
薬物動態制御によるナノ治療, 日本臨床, Vol. 64, 247-252, 2006
Non-methylated CpG motif packaged into fusogenic liposomes enhance antigen-specific immunity in mice, T Yoshikawa,S Imazu,JQ Gao,K Hayashi,Y Tsuda,N Okada,Y Tsutsumi,M Akashi,T Mayumi,S Nakagawa, BIOLOGICAL & PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOC JAPAN, Vol. 29, No. 1, p. 105-109, 2006/01
Vaccine efficacy of fusogenic liposomes containing tumor cell-lysate against murine B16BL6 melanoma, Tomoaki Yoshikawa,Naoki Okada,Masaki Tsujino,Jian-Qing Gao,Akira Hayashi,Yasuo Tsutsumi,Tadanori Mayumi,Akira Yamamoto,Shinsaku Nakagawa, Biological and Pharmaceutical Bulletin, Vol. 29, No. 1, p. 100-104, 2006/01
創薬の立場からのDDS：プロテオーム創薬からのDDS開発, 鎌田春彦,堤康央, 最新医学, Vol. 61, No. 6, p. 73-79, 2006
レクチャーノート：DDSの新しい潮流(5)～疾患プロテオミクス研究とDDS～, 堤康央, Drug Metabolism and Pharmacokinetics, Vol. 21, No. 21, p. 8-11, 2006
薬物動態制御によるナノ治療薬, 吉川友章,堤康央,中川晋作, 日本臨床, Vol. 64, No. 2, p. 247-252, 2006
両親媒化ポリグルタミン酸を用いた新規生分解性ワクチンキャリアの開発と抗腫ようワクチンへの応用―3, 飯田恵介,吉川友章,小田淳史,丹羽貴子,松尾一彦,萱室裕之,堤康央,赤木隆美,明石満,中川晋作, 日本免疫学会総会・学術集会記録, Vol. 35, 2005/11/15
両親媒化ポリγ‐グルタミン酸を用いた新規生分解性ナノキャリアの開発と抗腫ようワクチンへの応用―2, 小田淳史,吉川友章,丹羽貴子,飯田恵介,松尾一彦,萱室裕之,堤康央,赤木隆美,明石満,中川晋作, 日本免疫学会総会・学術集会記録, Vol. 35, 2005/11/15
変異型抗アポトーシス蛋白質Bcl‐xFNK発現樹状細胞を用いた抗腫よう効果に関する検討, 丹羽貴子,吉川友章,小田淳史,飯田恵介,松尾一彦,萱屋裕之,岡田直貴,堤康央,水口裕之,中川晋作, 日本免疫学会総会・学術集会記録, Vol. 35, 2005/11/15
IL‐12発現ベクターの腫よう内投与による抗腫よう効果と免疫系細胞の腫よう内浸潤の向上, 金川尚子,杉田敏樹,飯田恵介,畑中豊,谷洋一,水口裕之,堤康央,真弓忠範,中川晋作, 日本免疫学会総会・学術集会記録, Vol. 35, 2005/11/15
両親媒化ポリグルタミン酸を用いた新規生分解性ワクチンキャリアの開発と抗腫ようワクチンへの応用―1, 吉川友章,小田淳史,丹羽貴子,飯田恵介,松尾一彦,萱室裕之,堤康央,赤木隆美,明石満,中川晋作, 日本免疫学会総会・学術集会記録, Vol. 35, 2005/11/15
IL-12発現ベクターの腫瘍内投与による抗腫瘍効果と免疫系細胞の腫瘍内浸潤の向上, 金川尚子,杉田敏樹,飯田恵介,畑中豊,谷洋一,水口裕之,堤康央,真弓忠範,中川晋作, 日本免疫学会総会・学術集会記録, (NPO)日本免疫学会, Vol. 35, p. 130-130, 2005/11
腫ようターゲティングを目指したバイオコンジュゲート化アデノウイルスベクターの開発, 衛藤佑介,倉知慎之輔,水口裕之,堤康央,早川尭夫,真弓忠範,中川晋作, 日本癌学会学術総会記事, Vol. 64th, 2005/08/15
両親媒化ポリγ‐グルタミン酸を用いた腫ようワクチンアキャリアの開発, 吉川友章,飯田恵介,荒木隆美,荒木隆美,堤康央,明石満,中川晋作, 日本癌学会学術総会記事, Vol. 64th, p. 80-81, 2005/08/15
ポリエチレングリコール修飾アデノウイルスベクターのEPR効果に関する検討, 森重智弘,衛藤佑介,倉知慎之輔,よう醒らい,水口裕之,堤康央,早川尭夫,真弓忠範,中川晋作, Drug Deliv Syst, Vol. 20, No. 3, 2005/07/06
ワクチンキャリアとしてのポリアミノ酸由来生分解性ナノ粒子の有用性評価―2, 小田淳史,吉川友章,丹羽貴子,飯田恵介,松尾一彦,下川摩里子,堤康央,赤木隆美,明石満,中川晋作, Drug Delivery System, Vol. 20, No. 3, 2005/07/06
ナイーブ抗体ライブラリを用いた種々抗原に対する一本鎖抗体の迅速同定, 今井直,向洋平,杉田敏樹,長野一也,山名田夏枝,中川晋作,真弓忠範,鎌田春彦,角田慎一,堤康央, Drug Deliv Syst, Vol. 20, No. 3, 2005/07/06
IL‐12及びCCL27発現アデノウイルスベクターの併用投与による抗腫よう効果とその有用性評価, 杉田敏樹,高建青,金川尚子,本村吉章,飯田恵介,堤康央,水口裕之,義江修,真弓忠範,中川晋作, Drug Deliv Syst, Vol. 20, No. 3, 2005/07/06
細胞内トラフィック制御を指向した新規細胞内移行ペプチド(PTD)の開発とその評価, 大川亜紀子,川村真紀,柴田寛子,阿部康弘,野村鉄也,中川晋作,真弓忠範,鎌田春彦,角田慎一,堤康央, Drug Deliv Syst, Vol. 20, No. 3, 2005/07/06
IL‐12及びCCL27発現アデノウイルスベクターの併用投与による抗腫よう効果増強機構の解明, 本村吉章,杉田敏樹,高建青,金川尚子,飯田恵介,堤康央,水口裕之,義江修,真弓忠範,中川晋作, Drug Deliv Syst, Vol. 20, No. 3, 2005/07/06
ファージ表面提示法を駆使した新規ペプチド性キャリアの構築, 向洋平,大和友子,山名田夏枝,杉田敏樹,今井直,中川晋作,真弓忠範,鎌田春彦,角田慎一,堤康央, Drug Deliv Syst, Vol. 20, No. 3, 2005/07/06
IL‐12発現アデノウイルスベクターの腫よう内投与による抗腫よう効果と免疫細胞の腫よう内浸潤, 金川尚子,杉田敏樹,高建青,本村吉章,飯田恵介,柳川達也,堤康央,水口裕之,真弓忠範,中川晋作, Drug Deliv Syst, Vol. 20, No. 3, 2005/07/06
シンドビスウイルス外殻蛋白質断片化ペプチドライブラリを駆使した神経細胞特異的キャリアペプチドの探索, 野村鉄也,川村真紀,柴田寛子,阿部康弘,大川亜紀子,中川晋作,真弓忠範,鎌田春彦,角田晋一,堤康央, Drug Deliv Syst, Vol. 20, No. 3, 2005/07/06
ポリビニルピロリドンを用いた機能性修飾高分子の開発に関する基礎検討, 鎌田春彦,柴田寛子,阿部康弘,大川亜紀子,野村鉄也,佐藤雅紀,中川晋作,真弓忠範,角田慎一,堤康央, Drug Deliv Syst, Vol. 20, No. 3, 2005/07/06
活性増強変異型抗アポトーシス蛋白質Bcl‐xFNK発現樹状細胞を用いた腫ようワクチン療法, 丹羽貴子,吉川友章,小田淳史,飯田恵介,松尾一彦,下川摩里子,岡田直貴,堤康央,水口裕之,中川晋作, Drug Delivery System, Vol. 20, No. 3, 2005/07/06
細胞内移行性ペプチド(PTD)による細胞内物質導入法に関する基礎的検討, 山名田夏枝,向洋平,大和友子,杉田敏樹,今井直,中川晋作,真弓忠範,鎌田春彦,角田慎一,堤康央, Drug Deliv Syst, Vol. 20, No. 3, 2005/07/06
体内動態を制御できる修飾高分子の開発に向けた基礎検討, 柴田寛子,阿部康弘,大川亜紀子,野村鉄也,佐藤雅紀,中川晋作,真弓忠範,鎌田春彦,角田慎一,堤康央, Drug Deliv Syst, Vol. 20, No. 3, 2005/07/06
pH応答性薬物キャリアの開発とがん治療への応用, 阿部康弘,柴田寛子,大川亜紀子,野村鉄也,佐藤雅紀,中川晋作,真弓忠範,鎌田春彦,角田慎一,堤康央, Drug Deliv Syst, Vol. 20, No. 3, 2005/07/06
ワクチンキャリアとしてのポリアミノ酸由来生分解性ナノ粒子の有用性評価―1, 吉川友章,小田淳史,丹羽貴子,飯田恵介,松尾一彦,下川摩里子,堤康央,赤木隆美,明石満,中川晋作, Drug Delivery System, Vol. 20, No. 3, 2005/07/06
Fusogenic liposome delivers encapsulated nanoparticles for cytosolic controlled gene release, J Kunisawa,T Masuda,K Katayama,T Yoshikawa,Y Tsutsumi,M Akashi,T Mayumi,S Nakagawa, JOURNAL OF CONTROLLED RELEASE, ELSEVIER SCIENCE BV, Vol. 105, No. 3, p. 344-353, 2005/07
Anti-tumor responses induced by chemokine CCL19 transfected into an ovarian carcinoma model via fiber-mutant adenovirus vector, JQ Gao,T Sugita,N Kanagawa,K Iida,N Okada,H Mizuguchi,T Nakayama,T Hayakawa,O Yoshie,Y Tsutsumi,T Mayumi,S Nakagawa, BIOLOGICAL & PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOC JAPAN, Vol. 28, No. 6, p. 1066-1070, 2005/06
IL-12発現アデノウイルスベクターの腫瘍内投与による抗腫瘍効果と免疫細胞の腫瘍内浸潤, 金川尚子,杉田敏樹,高建青,本村吉章,飯田恵介,柳川達也,堤康央,水口裕之,真弓忠範,中川晋作, Drug Delivery System, 日本DDS学会, Vol. 20, No. 3, p. 359-359, 2005/05
PEGylated adenovirus vectors containing RGD peptides on the tip of PEG show high transduction efficiency and antibody evasion ability, Y Eto,JQ Gao,F Sekiguchi,S Kurachi,K Katayama,M Maeda,K Kawasaki,H Mizuguchi,T Hayakawa,Y Tsutsumi,T Mayumi,S Nakagawa, JOURNAL OF GENE MEDICINE, JOHN WILEY & SONS LTD, Vol. 7, No. 5, p. 604-612, 2005/05
変異型Bcl-XL(FNK)遺伝子導入樹状細胞を用いた腫瘍ワクチン療法の最適化(1), 丹羽貴子,吉川友章,小田淳史,下川摩里子,岡田直貴,堤康央,水口裕之,早川尭夫,麻生定光,太田成男,真弓忠範,中川晋作, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 125年会, No. 2, p. 91-91, 2005/03
変異型Bcl-XL(FNK)遺伝子導入樹状細胞を用いた腫瘍ワクチン療法の最適化(2), 吉川友章,丹羽貴子,小田淳史,下川摩里子,岡田直貴,堤康央,水口裕之,早川尭夫,麻生定光,太田成男,真弓忠範,中川晋作, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 125年会, No. 2, p. 91-91, 2005/03
IL-12発現アデノウイルスベクターを用いたIL-12非奏功性腫瘍に対する治療効果に関する検討, 金川尚子,高建青,杉田敏樹,飯田恵介,衛藤佑介,本村吉章,水口裕之,早川尭夫,堤康央,真弓忠範,中川晋作, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 125年会, No. 2, p. 153-153, 2005/03
Polyethylene Glycol修飾アデノウイルスベクターの腫瘍集積性に関する検討, 倉知慎之輔,衛藤佑介,高建青,森重智弘,櫻井文教,水口裕之,早川尭夫,堤康央,真弓忠範,中川晋作, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 125年会, No. 2, p. 154-154, 2005/03
腫瘍壊死因子の網羅的な構造変異体ライブラリの創出と構造-活性相関の基礎検討, 今井直,向洋平,柴田寛子,阿部康弘,川村真紀,大和友子,大川亜紀子,野村鉄也,山名田夏枝,中川晋作,真弓忠範,鎌田春彦,角田慎一,早川尭夫,堤康央, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 125年会, No. 2, p. 154-154, 2005/03
IL-12とCCL27の併用による抗腫瘍効果増強機構の解明, 杉田敏樹,高建青,金川尚子,飯田恵介,本村吉章,畑中豊,谷一,中山隆志,義江修,水口裕之,早川尭夫,岡田直貴,堤康央,弓忠範,中川晋作, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 125年会, No. 2, p. 154-154, 2005/03
A single intratumoral injection of a fiber-mutant adenoviral vector encoding interleukin 12 induces remarkable anti-tumor and anti-metastatic activity in mice with Meth-A fibrosarcoma, JQ Gao,T Sugita,N Kanagawa,K Iida,Y Eto,Y Motomura,H Mizuguchi,Y Tsutsumi,T Hayakawa,T Mayumi,S Nakagawa, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC ELSEVIER SCIENCE, Vol. 328, No. 4, p. 1043-1050, 2005/03
Phage display and PEGylation of therapeutic proteins, Y Mukai,Y Yoshioka,Y Tsutsumi, COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING, BENTHAM SCIENCE PUBL LTD, Vol. 8, No. 2, p. 145-152, 2005/03
ポリγ‐グルタミン酸を用いたガンワクチンキャリアの開発, 飯田恵介,吉川友章,小田淳史,丹羽貴子,松尾一彦,下川摩里子,堤康央,赤木隆美,明石満,中川晋作, 日本ワクチン学会学術集会プログラム・抄録集, Vol. 9th, 2005
Optimization of protein therapies by polymer-conjugation as an effective DDS, H Shibata,S Nakagawa,Y Tsutsumi, MOLECULES, MOLECULAR DIVERSITY PRESERVATION INTERNATIONAL, Vol. 10, No. 1, p. 162-180, 2005/01
Fusogenic liposome can be used as an effective vaccine carrier for peptide vaccination to induce cytotoxic T lymphocyte (CTL) response, T Sugita,T Yoshikawa,JQ Gao,M Shimokawa,A Oda,T Niwa,M Akashi,Y Tsutsumi,T Mayumi,S Nakagawa, BIOLOGICAL & PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOC JAPAN, Vol. 28, No. 1, p. 192-193, 2005/01
Augmentation of antigen-specific immune responses using DNA-fusogenic liposome vaccine, T Yoshikawa,S Imazu,JQ Gao,K Hayashi,Y Tsuda,M Shimokawa,T Sugita,T Niwa,A Oda,M Akashi,Y Tsutsumi,T Mayumi,S Nakagawa, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC ELSEVIER SCIENCE, Vol. 325, No. 2, p. 500-505, 2004/12
Functionalization of tumor necrosis factor-alpha using phage display technique and PEGylation improves its antitumor therapeutic window, H Shibata,Y Yoshioka,S Ikemizu,K Kobayashi,Y Yamamoto,Y Mukai,T Okamoto,M Taniai,M Kawamura,Y Abe,S Nakagawa,T Hayakawa,S Nagata,Y Yamagata,T Mayumi,H Kamada,Y Tsutsumi, CLINICAL CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, Vol. 10, No. 24, p. 8293-8300, 2004/12
IL-12及びCCL27発現アデノウイルスベクターの併用投与による抗腫瘍効果と免疫系細胞の浸潤, 杉田敏樹,畑中豊,谷洋一,中山隆志,義江修,水口裕之,早川高夫,岡田直貴,堤康央,真弓忠範,中川晋作, 日本免疫学会総会・学術集会記録, (NPO)日本免疫学会, Vol. 34, p. 215-215, 2004/11
医薬価値に優れた機能性人工TNF-αの創製とその疾病治療への展開, 向洋平,柴田寛子,大和友子,川村真紀,阿部康弘,今井直,大川亜紀子,中川晋作,真弓忠範,鎌田春彦,早川高夫,堤康央, 日本免疫学会総会・学術集会記録, (NPO)日本免疫学会, Vol. 34, p. 260-260, 2004/11
癌免疫療法の最適化を目指した機能性サイトカインの創出システムの開発とその評価, 柴田寛子,向洋平,川村真紀,大和友子,阿部康弘,今井直,大川亜紀子,中川晋作,真弓忠範,鎌田春彦,早川高夫,堤康央, 日本免疫学会総会・学術集会記録, (NPO)日本免疫学会, Vol. 34, p. 260-260, 2004/11
サイトカイン療法の最適化を目指した新規部位特異的バイオコンジュゲーション法の開発とその評価, 阿部康弘,柴田寛子,向洋平,川村真紀,大和友子,今井直,大川亜紀子,中川晋作,真弓忠範,鎌田春彦,早川高夫,堤康央, 日本免疫学会総会・学術集会記録, (NPO)日本免疫学会, Vol. 34, p. 261-261, 2004/11
ファージ抗体ライブラリによる抗原特異的モノクロナール抗体の網羅的な迅速単離, 今井直,向洋平,柴田寛子,大和友子,川村真紀,阿部康弘,大川亜紀子,中川晋作,真弓忠範,鎌田春彦,早川高夫,堤康央, 日本免疫学会総会・学術集会記録, (NPO)日本免疫学会, Vol. 34, p. 261-261, 2004/11
ファージ表面提示法を利用したウイルス感染を担うペプチド探索法の構築, 川村真紀,柴田寛子,向洋平,大和友子,阿部康弘,今井直,大川亜紀子,中川晋作,真弓忠範,鎌田春彦,早川高夫,堤康央, 日本免疫学会総会・学術集会記録, (NPO)日本免疫学会, Vol. 34, p. 262-262, 2004/11
抗体療法の最適化を目指したリジン欠損一本鎖抗体の創製, 大川亜紀子,向洋平,柴田寛子,川村真紀,大和友子,阿部康弘,今井直,中川晋作,真弓忠範,鎌田晴彦,早川高夫,堤康央, 日本免疫学会総会・学術集会記録, (NPO)日本免疫学会, Vol. 34, p. 261-261, 2004/11
細胞内薬物導入キャリアとしての細胞内移行ペプチドの特性評価, 大和友子,向洋平,柴田寛子,川村真紀,阿部康弘,今井直,大川亜紀子,中川晋作,真弓忠範,鎌田春彦,早川高夫,堤康央, 日本免疫学会総会・学術集会記録, (NPO)日本免疫学会, Vol. 34, p. 262-262, 2004/11
Development of novel DDS technologies for pharmacoproteomic-based drug discovery and development, Yasuo Tsutsumi, Yakugaku Zasshi, Vol. 124, No. 11, p. 769-780, 2004/11
Development of novel drug delivery system (DDS) technologies for proteomic-based drug development, H Shibata,S Nakagawa,T Mayumi,Y Tsutsumi, BIOLOGICAL & PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOC JAPAN, Vol. 27, No. 10, p. 1483-1488, 2004/10
Optimal construction of non-immune scFv phage display libraries from mouse bone marrow and spleen established to select specific scFvs efficiently binding to antigen, T Okamoto,Y Mukai,Y Yoshioka,H Shibata,M Kawamura,Y Yamamoto,S Nakagawa,H Kamada,T Hayakawa,T Mayumi,Y Tsutsumi, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC ELSEVIER SCIENCE, Vol. 323, No. 2, p. 583-591, 2004/10
Optimal construction of non-immune scFv phage display libraries from mouse bone marrow and spleen established to select specific scFvs efficiently binding to antigen, T Okamoto,Y Mukai,Y Yoshioka,H Shibata,M Kawamura,Y Yamamoto,S Nakagawa,H Kamada,T Hayakawa,T Mayumi,Y Tsutsumi, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC ELSEVIER SCIENCE, Vol. 323, No. 2, p. 583-591, 2004/10
Effective accumulation of poly(vinylpyrrolidone-co-vinyl laurate) into the spleen, Y Yoshioka,Y Tsutsumi,Y Mukai,H Shibata,T Okamoto,Y Kaneda,S Tsunoda,H Kamada,K Koizumi,Y Yamamoto,Y Mu,H Kodaira,K Sato-Kamada,S Nakagawa,T Mayumi, JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, WILEY-LISS, Vol. 70A, No. 2, p. 219-223, 2004/08
The targeting of anionized polyvinylpyrrolidone to the renal system, H Kodaira,Y Tsutsumi,Y Yoshioka,H Kamada,Y Kaneda,Y Yamamoto,S Tsunoda,T Okamoto,Y Mukai,H Shibata,S Nakagawa,T Mayumi, BIOMATERIALS, ELSEVIER SCI LTD, Vol. 25, No. 18, p. 4309-4315, 2004/08
The targeting of anionized polyvinylpyrrolidone to the renal system, H Kodaira,Y Tsutsumi,Y Yoshioka,H Kamada,Y Kaneda,Y Yamamoto,S Tsunoda,T Okamoto,Y Mukai,H Shibata,S Nakagawa,T Mayumi, BIOMATERIALS, ELSEVIER SCI LTD, Vol. 25, No. 18, p. 4309-4315, 2004/08
Recent progress on tumor missile therapy and tumor vascular targeting therapy as a new approach, Yasuo Yoshioka,Yasuo Tsutsumi,Shinsaku Nakagawa,Tadanori Mayumi, Current Vascular Pharmacology, Vol. 2, No. 3, p. 259-270, 2004/07
High gene expression of the mutant adenovirus vector, both in vitro and in vivo, with the insertion of integrin-targeting peptide into the fiber, JQ Gao,S Inoue,Y Tsukada,K Katayama,Y Eto,S Kurachi,H Mizuguchi,T Hayakawa,Y Tsutsumi,T Mayumi,S Nakagawa, PHARMAZIE, GOVI-VERLAG GMBH, Vol. 59, No. 7, p. 571-572, 2004/07
The use of PVP as a polymeric carrier to improve the plasma half-life of drugs, Y Kaneda,Y Tsutsumi,Y Yoshioka,H Kamada,Y Yamamoto,H Kodaira,S Tsunoda,T Okamoto,Y Mukai,H Shibata,S Nakagawa,T Mayumi, BIOMATERIALS, ELSEVIER SCI LTD, Vol. 25, No. 16, p. 3259-3266, 2004/07
High gene expression of the mutant adenovirus vector, both in vitro and in vivo, with the insertion of integrin-targeting peptide into the fiber, JQ Gao,S Inoue,Y Tsukada,K Katayama,Y Eto,S Kurachi,H Mizuguchi,T Hayakawa,Y Tsutsumi,T Mayumi,S Nakagawa, PHARMAZIE, GOVI-VERLAG GMBH, Vol. 59, No. 7, p. 571-572, 2004/07
The use of PVP as a polymeric carrier to improve the plasma half-life of drugs, Y Kaneda,Y Tsutsumi,Y Yoshioka,H Kamada,Y Yamamoto,H Kodaira,S Tsunoda,T Okamoto,Y Mukai,H Shibata,S Nakagawa,T Mayumi, BIOMATERIALS, ELSEVIER SCI LTD, Vol. 25, No. 16, p. 3259-3266, 2004/07
Neutralizing antibody evasion ability of adenovirus vector induced by the bioconjugation of methoxypolyethylene glycol succinimidyl propionate (MPEG-SPA), Y Eto,JQ Gao,F Sekiguchi,S Kurachi,K Katayama,H Mizuguchi,T Hayakawa,Y Tsutsumi,T Mayumi,S Nakagawa, BIOLOGICAL & PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOC JAPAN, Vol. 27, No. 6, p. 936-938, 2004/06
Neutralizing antibody evasion ability of adenovirus vector induced by the bioconjugation of methoxypolyethylene glycol succinimidyl propionate (MPEG-SPA), Y Eto,JQ Gao,F Sekiguchi,S Kurachi,K Katayama,H Mizuguchi,T Hayakawa,Y Tsutsumi,T Mayumi,S Nakagawa, BIOLOGICAL & PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOC JAPAN, Vol. 27, No. 6, p. 936-938, 2004/06
細胞内薬物導入キャリアとしての細胞内移行ペプチドの特性評価に関する基礎検討, 大和友子,向洋平,岡本貴行,柴田寛子,川村真紀,阿部康弘,中川晋作,堤康央,真弓忠範, Drug Deliv Syst, 日本DDS学会, Vol. 19, No. 3, p. 291-291, 2004/05/10
体内動態制御を目指したポリエチレングリコール修飾アデノウイルスベクターのin vivo遺伝子発現特性に関する検討, 倉知慎之輔,衛藤佑介,高建青,堤康央,水口裕之,早川尭夫,真弓忠範,中川晋作, Drug Deliv Syst, 日本DDS学会, Vol. 19, No. 3, p. 291-291, 2004/05/10
ファージ表面提示法を利用した新規細胞内移行ペプチドの網羅的探索システムの構築, 川村真紀,岡本貴行,柴田寛子,向洋平,大和友子,阿部康弘,中川晋作,堤康央,真弓忠範, Drug Deliv Syst, 日本DDS学会, Vol. 19, No. 3, p. 319-319, 2004/05/10
細胞内移行ペプチドを利用した細胞内薬物送達法の確立に向けた基礎的検討, 岡本貴行,川村真紀,柴田寛子,向洋平,大和友子,阿部康弘,中川晋作,堤康央,真弓忠範, Drug Deliv Syst, 日本DDS学会, Vol. 19, No. 3, p. 318-318, 2004/05/10
新規腎ターゲティングキャリアの開発と腎不全に対する蛋白療法の最適化, 向洋平,大和友子,岡本貴行,柴田寛子,川村真紀,阿部康弘,中川晋作,鎌田春彦,堤康央,真弓忠範, Drug Delivery System, 日本DDS学会, Vol. 19, No. 3, p. 272-272, 2004/05
プロテオーム創薬にかなう機能性人工蛋白質の迅速創出とそのバイオコンジュゲーションへの展開, 柴田寛子,阿部康弘,岡本貴行,向洋平,川村真紀,大和友子,中川晋作,吉岡靖雄,堤康央,真弓忠範, Drug Delivery System, 日本DDS学会, Vol. 19, No. 3, p. 272-272, 2004/05
ファージ表面提示法を駆使した部位特異的バイオコンジュゲーションの最適化, 阿部康弘,柴田寛子,岡本貴行,向洋平,川村真紀,大和友子,中川晋作,吉岡靖雄,堤康央,真弓忠範, Drug Delivery System, 日本DDS学会, Vol. 19, No. 3, p. 292-292, 2004/05
Anti-tumor activity of chemokine is affected by both kinds of tumors and the activation state of the host's immune system: implications for chemokine-based cancer immunotherapy, N Okada,JQ Gao,A Sasaki,M Niwa,Y Okada,T Nakayama,O Yoshie,H Mizuguchi,T Hayakawa,T Fujita,A Yamamoto,Y Tsutsumi,T Mayumi,S Nakagawa, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC ELSEVIER SCIENCE, Vol. 317, No. 1, p. 68-76, 2004/04
Design of a pH-sensitive polymeric carrier for drug release and its application in cancer therapy, H Kamada,Y Tsutsumi,Y Yoshioka,Y Yamamoto,H Kodaira,S Tsunoda,T Okamoto,Y Mukai,H Shibata,S Nakagawa,T Mayumi, CLINICAL CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, Vol. 10, No. 7, p. 2545-2550, 2004/04
Design of a pH-sensitive polymeric carrier for drug release and its application in cancer therapy, H Kamada,Y Tsutsumi,Y Yoshioka,Y Yamamoto,H Kodaira,S Tsunoda,T Okamoto,Y Mukai,H Shibata,S Nakagawa,T Mayumi, CLINICAL CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, Vol. 10, No. 7, p. 2545-2550, 2004/04
核内受容体PPARγを介したマスト細胞機能制御, 立花雅史,恵美真以子,形山和史,和田孝一郎,中島淳,門脇孝,堤康央,中川晋作,前山一隆, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 124th, No. 4, p. 37-37, 2004/03/05
ポリエチレングリコール修飾アデノウイルスベクターの体内動態に関する検討, 衛藤佑介,倉知慎之輔,高建青,形山和史,堤康央,水口裕之,早川尭夫,中川晋作,真弓忠範, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 124th, No. 4, p. 113-113, 2004/03/05
shRNA発現レンチウイルスベクターの作製と機能評価, 形山和史,三好浩之,水口裕之,立花雅史,大橋興三,古木理恵,川端健二,堤康央,中川晋作, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 124th, No. 4, p. 113-113, 2004/03/05
細胞内移行ペプチドを利用した細胞内薬物デリバリーに関する基礎的検討, 岡本貴行,川村真紀,吉岡靖雄,柴田寛子,清水智絵,向洋平,阿部康弘,堤康央,中川晋作, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 124th, No. 4, p. 114-114, 2004/03/05
膜融合リポソーム(FL)内封ナノ粒子の生体内動態解析, 吉川友章,杉田敏樹,丹羽貴子,下川摩里子,堤康央,中川晋作,真弓忠範, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 124th, No. 4, p. 115-115, 2004/03/05
医薬価値に優れた新規機能性ペプチドの網羅的探索システムの構築, 川村真紀,岡本貴行,吉岡靖雄,柴田寛子,清水智絵,向洋平,阿部康弘,堤康央,中川晋作, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 124th, No. 4, p. 114-114, 2004/03/05
膜融合リポソームによるHTLV‐1ペプチドワクチンの開発, 杉田敏樹,吉川友章,下川摩里子,山本記裕,大和友子,金川尚子,丹羽貴子,堤康央,中川晋作, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 124th, No. 4, p. 114-114, 2004/03/05
抗体療法の最適化を目指した創薬基盤テクノロジーの開発, 堤康央,中川晋作,真弓忠範, 日本薬学会年会要旨集, Vol. 124th, No. 1, 2004/03/05
新規腎ターゲティングキャリアーの腎疾患治療への応用, 柴田寛子,吉岡靖雄,向洋平,阿部康弘,岡本貴行,清水智絵,川村真紀,鎌田春彦,堤康央,中川晋作,真弓忠範, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 124年会, No. 4, p. 114-114, 2004/03
shRNA発現レンチウイルスベクターを用いたPPARγノックダウン法の確立, 大橋興三,形山和史,和田孝一郎,三好浩之,水口裕之,立花雅史,古木理恵,中島淳,門脇孝,堤康央,中川晋作,早川尭夫,真弓忠範, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 124年会, No. 4, p. 114-114, 2004/03
蛋白療法の最適化に向けた腎ターゲティングキャリアの開発, 向洋平,吉岡靖雄,柴田寛子,阿部康弘,岡本貴行,清水智絵,川村真紀,鎌田春彦,堤康央,中川晋作,真弓忠範, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 124年会, No. 4, p. 114-114, 2004/03
Tumor-suppressive activities by chemokines introduced into OV-HM cells using fiber-mutant adenovirus vectors, JQ Gao,LS Alexandre,Y Tsuda,K Katayama,Y Eto,F Sekiguchi,H Mizuguchi,T Hayakawa,T Nakayama,O Yoshie,Y Tsutsumi,T Mayumi,S Nakagawa, PHARMAZIE, GOVI-VERLAG GMBH, Vol. 59, No. 3, p. 238-239, 2004/03
Selective enhancer of tumor vascular permeability for optimization of cancer chemotherapy, Y Yoshioka,Y Tsutsumi,H Kamada,T Kihira,S Tsunoda,Y Yamamoto,T Okamoto,H Shibata,Y Mukai,M Taniai,T Shimizu,M Kawamura,Y Abe,S Nakagawa,T Mayumi, BIOLOGICAL & PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOC JAPAN, Vol. 27, No. 3, p. 437-439, 2004/03
Optimal site-specific PEGylation of mutant TNF-alpha improves its antitumor potency, Y Yoshioka,Y Tsutsumi,S Ikemizu,Y Yamamoto,H Shibata,T Nishibata,Y Mukai,T Okamoto,M Taniai,M Kawamura,Y Abe,S Nakagawa,S Nagata,Y Yamagata,T Mayumi, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC ELSEVIER SCIENCE, Vol. 315, No. 4, p. 808-814, 2004/03
Poly(vinylpyrrolidone-co-dimethyl maleic acid) as a novel renal targeting carrier, Y Yamamoto,Y Tsutsumi,Y Yoshioka,H Kamada,K Sato-Kamada,T Okamoto,Y Mukai,H Shibata,S Nakagawa,T Mayumi, JOURNAL OF CONTROLLED RELEASE, ELSEVIER SCIENCE BV, Vol. 95, No. 2, p. 229-237, 2004/03
Tumor-suppressive activities by chemokines introduced into OV-HM cells using fiber-mutant adenovirus vectors, J. Q. Gao,L. S. Alexandre,Y. Tsuda,K. Katayama,Y. Eto,F. Sekiguchi,H. Mizuguchi,T. Hayakawa,T. Nakayama,O. Yoshie,Y. Tsutsumi,T. Mayumi,Shinsaku Nakagawa, Pharmazie, Vol. 59, No. 3, p. 238-239, 2004/03
Poly(vinylpyrrolidone-co-dimethyl maleic acid) as a novel renal targeting carrier, Y Yamamoto,Y Tsutsumi,Y Yoshioka,H Kamada,K Sato-Kamada,T Okamoto,Y Mukai,H Shibata,S Nakagawa,T Mayumi, JOURNAL OF CONTROLLED RELEASE, ELSEVIER SCIENCE BV, Vol. 95, No. 2, p. 229-237, 2004/03
RNA interfering approach for clarifying the PPAR gamma pathway using lentiviral vector expressing short hairpin RNA, K Katayama,K Wada,H Miyoshi,K Ohashi,M Tachibana,R Furuki,H Mizuguchi,T Hayakawa,A Nakajima,T Kadowaki,Y Tsutsumi,S Nakagawa,Y Kamisaki,T Mayumi, FEBS LETTERS, ELSEVIER SCIENCE BV, Vol. 560, No. 1-3, p. 178-182, 2004/02
Development of antisense drugs using bridged nucleic acid analog bearing and its practical application., 今西武,真弓忠範,土井健史,中川晋作,宮下和之,小比賀聡,堤康央, 創薬等ヒューマンサイエンス研究総合研究報告書平成13-15年度第1分野先端的創薬技術の開発に関する研究, p. 73-78, 2004
Bioconjugation of peptides and proteins with polymeric modifiers for improvement of their therapeutic efficacy, Mukai Y,Tsutsumi Y,Corresponding Author,Yoshioka Y,Mayumi T, Current topics in peptides and protein research, No. 6, p. 167-176, 2004
The optimal molecular design of polymeric drug carriers and its application for renal drug targeting, Okamoto T,Nakagawa S,Tsutsumi Y,Corres,o,ding Au, Gene Ther. Mol. Biol., Vol. 8, p. 221-229, 2004
ファージ表面提示法を駆使した機能性人工蛋白質の創製とDDSへの応用, 向洋平,真弓忠範,堤康央, Bioベンチャー, Vol. 4, No. 6, p. 65-68, 2004
蛋白療法の最適化に叶うDDSの開発を目指して., 堤康央, 薬剤学(生命とくすり), Vol. 64, No. 3, p. 159-163, 2004
蛋白療法の最適化に叶う新たな薬物送達戦略, 柴田寛子,真弓忠範,堤康央, 医学のあゆみ, Vol. 210, No. 9, p. 730-736, 2004
Enhanced gene expression of adenovirus vector in tumor induced by the PEGｙlation., Pharmaceutical Sciences World Congress(PSWC2004),Kyoto, 2004
Efficient delivery of encapsulated molecule to antigen presenting cells by Fusogenic-Liposome., Pharmaceutical Sciences World Congress(PSWC2004),Kyoto, 2004
Pharmacoproteomic－based drug discovery and development using mutant cytokines-displayed phage libraries, Pharmaceutical Sciences World Congress(PSWC2004),Kyoto, 2004
Okamoto T., Nakagawa S., Tsutsumi Y.(Corresponding Author): The optimal molecular design of polymeric drug carriers and its application for renal drug targeting., Gene Therapy and, Molecular Biology, Vol. 8: 221-229, 2004
Y. Yoshioka, Y. Tsutsumi, S. Nakagawa, T. Mayumi Recent progress on tumor missile therapy and tumor vascular targeting therapy as a new approach., Current Vascular Pharmacology, Vol. 2(3), 259-270, 2004
Y. Yoshioka, Y. Tsutsumi, H. Kamada, T. Kihira, S. Tsunoda, Y. Yamamoto, T. Okamoto, H. Shibata, Y. Mukai, M. Taniai, T. Shimizu, M. Kawamura, Y. Abe, S. Nakagawa, T. Mayumi Selective enhancer of tumor vascular permeability for optimization of cancer ・・・, Biol. Pharm. Bull., Vol. 27(3), 437-439, 2004
Y. Yoshioka, Y. Tsutsumi, Y. Mukai, H. Shibata, T. Okamoto, Y. Kaneda, S. Tsunoda, H. Kamada, K. Koizumi, Y. Yamamoto, Y. Mu, H. Kodaira, K. Kamada-Sato, S. Nakagawa, Mayumi T. Effevctive accumulation of poly(vinylpyrrolidone-co-vinyl laurate) into the・・・, J. Biomed. Materials Res., Vol. 70A(2): 219-223, 2004
N. Okada, J.Q. Gao, A. Sasaki, M. Niwa, Y. Okada, T. Nakayama, O. Yoshie, H. Mizuguchi, T. Hayakawa, T. Fujita, A. Yamamoto, Y. Tsutsumi, T. Mayumi, S. Nakagawa. Anti-tumor activity of chemokine is affected by both the kinds of tumors and the activatio・・・, Biochem. Biophys. Res. Commun., Vol. 317(1): 68-76, 2004
Y. Yoshioka, Y. Tsutsumi, Y. Yamamoto, H. Shibata, T. Nishibata, Y. Mukai, T. Okamoto, M. Taniai, T. Shimizu, M. Kawamura, Y. Abe, S. Nakagawa, S. Nagata, T. Mayumi Optimal site-specific PEGylation of mutant TNF-s improves its antitumor potency., Biochem. Biophys. Res. Commun., Vol. 315(4), 808-814, 2004
K. Katayama, K. Wada, H. Miyoshi, K. Ohashi, M. Tachibana, R. Furuki, H. Mizuguchi, T. Hayakawa, A. Nakajima, T. Kadowaki, Y. Tsutsumi, S. Nakagawa, Y. Kamisaki, T. Mayumi RNA interfering approach for clarifying the PPAR pathway using lentiviral vecto・・・, FEBS Lett., Vol. 560(1-3), 178-182, 2004
Combination effects of complement regulatory proteins and anti-complement polymer, Y Yoshioka,R Suzuki,T Okamoto,N Okada,Y Mukai,H Shibata,Y Tsutsumi,N Dohi,N Okada,S Nakagawa,T Mayumi, BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, ELSEVIER SCIENCE BV, Vol. 1624, No. 1-3, p. 54-59, 2003/12
Anti-angiogenic effects of dimethyl sulfoxide on endothelial cells, K Koizumi,Y Tsutsumi,Y Yoshioka,M Watanabe,T Okamoto,Y Mukai,S Nakagawa,T Mayumi, BIOLOGICAL & PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOC JAPAN, Vol. 26, No. 9, p. 1295-1298, 2003/09
医薬価値に優れた機能性人工蛋白質を迅速創製可能な創薬戦略の確立に向けて, 吉岡靖雄,堤康央,中川晋作,真弓忠範, 日本癌学会総会記事, 日本癌学会, Vol. 62nd, p. 159-159, 2003/08/25
Antitumor effect by interleukin-11 receptor alpha-locus chemokine/CCL27, introduced into tumor cells through a recombinant adenovirus vector, JQ Gao,Y Tsuda,K Katayama,T Nakayama,Y Hatanaka,Y Tani,H Mizuguchi,T Hayakawa,O Yoshie,Y Tsutsumi,T Mayumi,S Nakagawa, CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, Vol. 63, No. 15, p. 4420-4425, 2003/08
Incorporation of adult organ-derived endothelial cells into tumor blood vessel, K Koizumi,Y Tsutsumi,H Kamada,Y Yoshioka,M Watanabe,Y Yamamoto,T Okamoto,Y Mukai,S Nakagawa,Y Tani,T Mayumi, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC ELSEVIER SCIENCE, Vol. 306, No. 1, p. 219-224, 2003/06
Incorporation of adult organ-derived endothelial cells into tumor blood vessel, K Koizumi,Y Tsutsumi,H Kamada,Y Yoshioka,M Watanabe,Y Yamamoto,T Okamoto,Y Mukai,S Nakagawa,Y Tani,T Mayumi, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC ELSEVIER SCIENCE, Vol. 306, No. 1, p. 219-224, 2003/06
改良型アデノウイルスベクターを用いた胎盤への遺伝子導入, 古木理恵,形山和史,立花雅史,大橋興三,堤康央,中川晋作,水口裕之,早川尭夫,真弓忠範, Drug Deliv Syst, 日本DDS学会, Vol. 18, No. 3, p. 250-250, 2003/05/10
抗TNF療法の最適化に向けた1本鎖抗体の部位特異的バイオコンジュゲーションに関する基礎的検討, 川村真紀,岡本貴行,吉岡靖雄,向洋平,清水智絵,柴田寛子,堤康央,中川晋作,真弓忠範, Drug Deliv Syst, 日本DDS学会, Vol. 18, No. 3, p. 296-296, 2003/05/10
A novel cytomedical vehicle capable of protecting cells against complement, Y Yoshioka,R Suzuki,H Oka,N Okada,T Okamoto,T Yoshioka,Y Mukai,H Shibata,Y Tsutsumi,S Nakagawa,J Miyazaki,T Mayumi, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC ELSEVIER SCIENCE, Vol. 305, No. 2, p. 353-358, 2003/05
Site-specific PEGylation of a lysine-deficient TNF-alpha with full bioactivity, Y Yamamoto,Y Tsutsumi,Y Yoshioka,T Nishibata,K Kobayashi,T Okamoto,Y Mukai,T Shimizu,S Nakagawa,S Nagata,T Mayumi, NATURE BIOTECHNOLOGY, NATURE PUBLISHING GROUP, Vol. 21, No. 5, p. 546-552, 2003/05
Site-specific PEGylation of a lysine-deficient TNF-alpha with full bioactivity, Y Yamamoto,Y Tsutsumi,Y Yoshioka,T Nishibata,K Kobayashi,T Okamoto,Y Mukai,T Shimizu,S Nakagawa,S Nagata,T Mayumi, NATURE BIOTECHNOLOGY, NATURE PUBLISHING GROUP, Vol. 21, No. 5, p. 546-552, 2003/05
Synthesis of a poly(vinylpyrrolidone-co-dimethyl maleic anhydride) co-polymer and its application for renal drug targeting, H Kamada,Y Tsutsumi,K Sato-Kamada,Y Yamamoto,Y Yoshioka,T Okamoto,S Nakagawa,S Nagata,T Mayumi, NATURE BIOTECHNOLOGY, NATURE PUBLISHING GROUP, Vol. 21, No. 4, p. 399-404, 2003/04
Synthesis of a poly(vinylpyrrolidone-co-dimethyl maleic anhydride) co-polymer and its application for renal drug targeting, H Kamada,Y Tsutsumi,K Sato-Kamada,Y Yamamoto,Y Yoshioka,T Okamoto,S Nakagawa,S Nagata,T Mayumi, NATURE BIOTECHNOLOGY, NATURE PUBLISHING GROUP, Vol. 21, No. 4, p. 399-404, 2003/04
目的とする生理活性を完全に保持した機能性変異蛋白質の迅速構築とそのDDSへの応用, 吉岡靖雄,堤康央,山本陽子,小林恭子,柴田寛子,岡本貴行,吉川友章,清水はな,清水智絵,向洋平,川村真紀,中川晋作,真弓忠範, 薬剤学: 生命とくすり, (公社)日本薬剤学会, Vol. 63, No. Suppl., p. 118-118, 2003/03/05
ケモカイン及びサイトカイン発現アデノウイルスベクターの併用による癌遺伝子治療の最適化, 高建青,形山和史,SOARES A L,水口裕之,早川尭夫,中山隆志,義江修,堤康央,中川晋作, 薬剤学, (公社)日本薬剤学会, Vol. 63, No. Supplement, p. 232-232, 2003/03/05
新規粘膜ワクチンキャリアーとしてのFusogenic liposome(FL):FLが有するアジュバント効果, 有山輝子,広井隆親,形山和史,国沢純,堤康央,中川晋作,清野宏,真弓忠範, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 123rd, No. 4, p. 83-83, 2003/03/05
RGDペプチドを付与したポリエチレングリコール修飾アデノウイルスベクターの機能評価, 関口文子,衛藤佑介,高健青,形山和史,堤康央,前田光子,川崎紘一,水口裕之,中川晋作, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 123rd, No. 4, p. 84-84, 2003/03/05
ファージ表面提示法を駆使した部位特異的バイオコンジュゲーションの最適化, 柴田寛子,吉岡靖雄,小林恭子,岡本貴行,堤康央,中川晋作,真弓忠範, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 123rd, No. 4, p. 86-86, 2003/03/05
抗TNF‐alpha療法の最適化に向けて:TNF‐alphaに対する1本鎖抗体の作製とその特性評価, 岡本貴行,吉岡靖雄,向洋平,川村真紀,堤康央,中川晋作,真弓忠範, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 123rd, No. 4, p. 86-86, 2003/03/05
Phage display systemを利用した機能性1本鎖抗体の創出に関する基礎的検討, 向洋平,吉岡靖雄,岡本貴行,川村真紀,堤康央,中川晋作,真弓忠範, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 123rd, No. 4, p. 87-87, 2003/03/05
改良型アデノウイルスベクターを用いた胎盤への遺伝子導入, 立花雅史,形山和史,古木理恵,大橋興三,堤康央,中川晋作,水口裕之,早川尭夫,真弓忠範, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 123rd, No. 4, p. 85-85, 2003/03/05
医薬価値に優れた機能性人工蛋白質の設計戦略確立に向けて 1, 清水智絵,吉岡靖雄,小林恭子,吉川友章,岡本貴行,柴田寛子,堤康央,中川晋作,真弓忠範, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 123rd, No. 4, p. 87-87, 2003/03/05
医薬価値に優れた機能性人工蛋白質の設計戦略確立に向けて 2, 吉川友章,吉岡靖雄,小林恭子,岡本貴行,柴田寛子,清水智絵,堤康央,中川晋作,真弓忠範, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 123rd, No. 4, p. 87-87, 2003/03/05
A novel T7 system utilizing mRNA coding for T7 RNA polymerase, R Nakano,T Nakagawa,S Imazu,K Katayama,H Mizuguchi,T Hayakawa,Y Tsutsumi,S Nakagawa,T Mayumi, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC ELSEVIER SCIENCE, Vol. 301, No. 4, p. 974-978, 2003/02
A novel T7 system utilizing mRNA coding for T7 RNA polymerase, R Nakano,T Nakagawa,S Imazu,K Katayama,H Mizuguchi,T Hayakawa,Y Tsutsumi,S Nakagawa,T Mayumi, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC ELSEVIER SCIENCE, Vol. 301, No. 4, p. 974-978, 2003/02
アンチセンスBNAオリゴヌクレオチドによるICAM‐1発現抑制, 中川晋作,増田幸史,HEMAMAYI Ramli,杉本友美,堤康央,小比賀聡,今西武,真弓忠範, アンチセンスシンポジウム講演要旨集, Vol. 13th, 2003
プロテオーム/プロテオミクス, 堤康央, DDS, Vol. 18, No. 6, 2003
Creation of functional bioactive muteins using phage display technique results in a novel drug delivery system, Yasuo Tsutsumi,Tadanori Mayumi, Drug Delivery System, Vol. 18, No. 6, p. 536-544, 2003
医薬価値に優れた機能性人工タンパク質の網羅的かつ迅速同定システムとプロテオーム創薬への展開, 堤康央,吉岡靖雄,真弓忠範, 細胞工学, Vol. 22, No. 8, p. 873-881, 2003
機能性高分子キャリアの開発とプロテオーム創薬への展開, 堤康央,鎌田春彦,真弓忠範, Bioベンチャー, Vol. 3, No. 4, p. 56-57, 2003
プロテオーム創薬にかなう機能性人工蛋白質の迅速創出とそのPEGylationへの展開, 堤康央,真弓忠範, 蛋白質核酸酵素-増刊号, 共立出版, Vol. 48, No. 11, p. 1519-1526, 2003
高分子化医薬(PEG化製剤), 堤康央,真弓忠範, 血液･免疫･腫瘍, Vol. 8, No. 2, p. 56-62, 2003
Anti-tumor effects of the CC chemokine, interleukin-11 receptor α-locus chemokine (ILC) using recombinant adenovirus vector., 2nd International Congress on Drug Absorption Transport and Delivery, Hawaii, USA, 2003/01
Y. Yoshioka, R. Suzuki, T. Okamoto, N. Okada, Y. Mukai, H. Shibata, Y. Tsutsumi, N. Dohi, N. Okada, S. Nakagawa, T. Mayumi Combination effects of complement regulatory proteins and anti-complement polymer., Biochim. Biophys. Acta., Vol. 1624, 54-59, 2003
K. Koizumi, Y. Tsutsumi, Y. Yoshioka, M. Watanabe, T. Okamoto, Y. Mukai, S. Nakagawa, T. Mayumi Anti-angiogenic effects of dimethyl sulfoxide on endothelial cells., Biol. Pharm. Bull., Vol. 26(9), 1295-1298, 2003
Y. Yoshioka, R. Suzuki, H. Oka, N. Okada, T. Okamoto, T. Yoshioka, Y. Mukai, H. Shibata, Y. Tsutsumi, S. Nakagawa, J. Miyazaki, T. Mayumi A novel cytomedical vehicle capable of protecting cells against complement., Biochem. Biophys. Res. Commun., Vol. 305, 353-358, 2003
J.Q.Gao, Y. Tsuda, K. Katayama, T. Nakayama, Y. Hatanaka, Y. Tani, H. Mizuguchi, T. Hayakawa, O.Yoshie, Y. Tsutsumi, T. Mayumi, S. Nakagawa Antitumor effect by interleukin-11 receptor -locus chemokine/ CCL27, introduced into tumor cells through a rec・・・, Cancer Research, Vol. 63, 4420-4425, 2003
部位特異的バイオコンジュゲーション・システムの構築リジン欠損TNF‐α変異体の作製とその評価, 吉岡靖雄,堤康央,宮本陽子,中川晋作,真弓忠範, 日本癌学会総会記事, Vol. 61st, 2002/08/25
Lack of antigen-specific immune responses in anti-IL-7 receptor alpha chain antibody-treated Peyer's patch-null mice following intestinal immunization with microencapsulated antigen, J Kunisawa,Takahashi, I,A Okudaira,T Hiroi,K Katayama,T Ariyama,Y Tsutsumi,S Nakagawa,H Kiyono,T Mayumi, EUROPEAN JOURNAL OF IMMUNOLOGY, WILEY-V C H VERLAG GMBH, Vol. 32, No. 8, p. 2347-2355, 2002/08
Cytomedical therapy for insulinopenic diabetes using microencapsulated pancreatic beta cell lines, R Suzuki,N Okada,H Miyamoto,T Yoshioka,K Sakamoto,H Oka,Y Tsutsumi,S Nakagawa,J Miyazaki,T Mayumi, LIFE SCIENCES, PERGAMON-ELSEVIER SCIENCE LTD, Vol. 71, No. 15, p. 1717-1729, 2002/08
Cytomedical therapy for insulinopenic diabetes using microencapsulated pancreatic beta cell lines, R Suzuki,N Okada,H Miyamoto,T Yoshioka,K Sakamoto,H Oka,Y Tsutsumi,S Nakagawa,J Miyazaki,T Mayumi, LIFE SCIENCES, PERGAMON-ELSEVIER SCIENCE LTD, Vol. 71, No. 15, p. 1717-1729, 2002/08
Lack of antigen-specific immune responses in anti-IL-7 receptor alpha chain antibody-treated Peyer's patch-null mice following intestinal immunization with microencapsulated antigen, J Kunisawa,Takahashi, I,A Okudaira,T Hiroi,K Katayama,T Ariyama,Y Tsutsumi,S Nakagawa,H Kiyono,T Mayumi, EUROPEAN JOURNAL OF IMMUNOLOGY, WILEY-V C H VERLAG GMBH, Vol. 32, No. 8, p. 2347-2355, 2002/08
Cytomedical therapy for insulinopenic diabetes using microencapsulated pancreatic beta cell lines, R Suzuki,N Okada,H Miyamoto,T Yoshioka,K Sakamoto,H Oka,Y Tsutsumi,S Nakagawa,J Miyazaki,T Mayumi, LIFE SCIENCES, PERGAMON-ELSEVIER SCIENCE LTD, Vol. 71, No. 15, p. 1717-1729, 2002/08
Therapy of rat tracheal carcinoma IC-12 in SCID mice: vascular targeting with [Bi-213]-MAb TES-23, SJ Kennel,T Lankford,S Davern,L Foote,K Taniguchi,Ohizumi, I,Y Tsutsumi,S Nakagawa,T Mayumi,S Mirzadeh, EUROPEAN JOURNAL OF CANCER, PERGAMON-ELSEVIER SCIENCE LTD, Vol. 38, No. 9, p. 1278-1287, 2002/06
Therapy of rat tracheal carcinoma IC-12 in SCID mice: vascular targeting with [Bi-213]-MAb TES-23, SJ Kennel,T Lankford,S Davern,L Foote,K Taniguchi,Ohizumi, I,Y Tsutsumi,S Nakagawa,T Mayumi,S Mirzadeh, EUROPEAN JOURNAL OF CANCER, PERGAMON-ELSEVIER SCIENCE LTD, Vol. 38, No. 9, p. 1278-1287, 2002/06
Therapy of rat tracheal carcinoma IC-12 in SCID mice: vascular targeting with [Bi-213]-MAb TES-23, SJ Kennel,T Lankford,S Davern,L Foote,K Taniguchi,Ohizumi, I,Y Tsutsumi,S Nakagawa,T Mayumi,S Mirzadeh, EUROPEAN JOURNAL OF CANCER, PERGAMON-ELSEVIER SCIENCE LTD, Vol. 38, No. 9, p. 1278-1287, 2002/06
ファージディスプレイシステムを用いた有効な生理活性蛋白質の創出, 小林恭子,山本陽子,西端俊秀,清水智絵,堤康央,中川晋作,真弓忠範, Drug Deliv Syst, 日本DDS学会, Vol. 17, No. 3, p. 278-278, 2002/05/10
ファージ抗体ライブラリによるモノクローナル抗体の網羅的迅速単離とその抗体療法の最適化に関する基礎的検討, 岡本貴行,吉岡靖雄,堤康央,向洋平,中川晋作,真弓忠範, Drug Deliv Syst, 日本DDS学会, Vol. 17, No. 3, p. 281-281, 2002/05/10
遺伝子治療の最適化を目指したアデノウイルスベクターのPolyethylene Glycol修飾と遺伝子発現活性, 関口文子,形山和史,林哲,津田育宏,堤康央,水口裕之,早川尭夫,真弓忠範,中川晋作, Drug Deliv Syst, 日本DDS学会, Vol. 17, No. 3, p. 293-293, 2002/05/10
g8p提示型ファージペプチドライブラリの構築及び機能評価, 吉川友章,山本陽子,形山和史,吉岡靖雄,堤康央,中川晋作,真弓忠範, Drug Deliv Syst, 日本DDS学会, Vol. 17, No. 3, p. 282-282, 2002/05/10
部位特異的バイオコンジュゲーション・システムの構築リジン欠損TNF-α変異体の作製とその評価, 吉岡靖雄,堤康央,山本陽子,西端俊秀,小林恭子,岡本貴行,吉川友章,清水智絵,向洋平,中川晋作, Drug Delivery System, 日本DDS学会, Vol. 17, No. 3, p. 255-255, 2002/05
Molecular design of bioconjugated cell adhesion peptide with a water-soluble polymeric modifier for enhancement of antimetastatic effect, Y Yamamoto,Y Tsutsumi,T Mayumi, CURRENT DRUG TARGETS, BENTHAM SCIENCE PUBL LTD, Vol. 3, No. 2, p. 123-130, 2002/04
Molecular design of bioconjugated cell adhesion peptide with a water-soluble polymeric modifier for enhancement of antimetastatic effect, Y Yamamoto,Y Tsutsumi,T Mayumi, CURRENT DRUG TARGETS, BENTHAM SCIENCE PUBL LTD, Vol. 3, No. 2, p. 123-130, 2002/04
癌抗原WT1標的癌ワクチン療法に向けた抗原デリバリーデバイス, 今井大介,林哲,脇田久嗣,坪井昭博,岡芳弘,杉山治夫,大杉義征,堤康央,中川晋作,真弓忠範, 薬剤学, Vol. 62, p. 143-143, 2002/03/05
インテグリン指向性ファイバーミュータントアデノウイルスベクターの改良とその評価, 井上暢子,形山和史,堤康央,中川晋作,水口裕之,早川尭夫,真弓忠範, 薬剤学, (公社)日本薬剤学会, Vol. 62, No. Supplement, p. 252-252, 2002/03/05
Polyethylene Glycolを用いたバイオコンジュゲート化アデノウイルスベクターの粒子設計, 関口文子,長谷和明,形山和史,林哲,堤康央,中川晋作,水口裕之,早川尭夫,真弓忠範, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 122nd, No. 4, p. 77-77, 2002/03/05
機能性ペプチドの網羅的検索・同定を目的としたファージ表面ランダムペプチド提示ライブラリの構築, 小林恭子,山本陽子,西端俊秀,清水智絵,堤康央,中川晋作,真弓忠範, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 122nd, No. 4, p. 83-83, 2002/03/05
ナイーブ一本鎖抗体提示phage libraryの構築および特異的抗体単離に関する検討 (その1) phage libraryの作製, 吉岡靖雄,岡本貴行,向洋平,堤康央,中川晋作,真弓忠範, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 122nd, No. 4, p. 83-83, 2002/03/05
アデノウイルスファイバー領域を提示したファージの構築とそのペプチドライブラリ化, 吉川友章,山本陽子,形山和史,吉岡靖雄,水口裕之,早川尭夫,堤康央,中川晋作,真弓忠範, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 122nd, No. 4, p. 80-80, 2002/03/05
ナイーブ一本鎖抗体提示phage libraryの構築および特異的抗体単離に関する検討 (その2) 特異的抗体単離に関する検討, 岡本貴行,吉岡靖雄,向洋平,堤康央,中川晋作,真弓忠範, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 122nd, No. 4, p. 83-83, 2002/03/05
Phage display systemを利用した部位特異的バイオコンジュゲーション法の開発, 山本陽子,西端俊秀,小林恭子,清水智絵,堤康央,中川晋作,真弓忠範, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 122nd, No. 4, p. 83-83, 2002/03/05
小胞体挿入配列を含むモデル癌抗原を用いた抗癌免疫誘導, 林哲,脇田久嗣,今井大介,堤康央,中川晋作,真弓忠範, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 122nd, No. 3, p. 139-139, 2002/03/05
PPARγ発現アデノウイルスベクターによる炎症性腸疾患治療法の開発, 形山和史,和田孝一郎,中島淳,吉田幸子,立花雅史,水口裕之,早川堯夫,堤康央,中川晋作,上崎善規,門脇孝,永井良三,真弓忠範, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 122年会, No. 4, p. 12-12, 2002/03
特定組織移行・再構築細胞の検索神経幹細胞の生存と分化, 西端俊秀,山本陽子,鎌田春彦,小泉桂一,堤康央,中川晋作,島崎琢也,岡野栄之,岡部勝,真弓忠範, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 122年会, No. 4, p. 84-84, 2002/03
Development of antisense drug articles using super functionality nucleic acid analogue (BNA) and the practical application ( human science promotion foundation S )., 今西武,真弓忠範,土井健史,宮下和之,中川晋作,小比賀聡,堤康央, 創薬等ヒューマンサイエンス研究重点研究報告書平成13年度第1分野先端的創薬技術の開発に関する研究, p. 59-65, 2002
Development of a novel cytomedical treatment that can protect entrapped cells from host humoral immunity, Ryo Suzuki,Yasuo Yoshioka,Etsuko Kitano,Tatsunobu Yoshioka,Hiroaki Oka,Takayuki Okamoto,Naoki Okada,Yasuo Tsutsumi,Shinsaku Nakagawa,Jun-ichi Miyazaki,Hajime Kitamura,Tadanori Mayumi, Cell Transplantation, Vol. 11, No. 8, p. 787-798, 2002
ナノサイエンス・ナノテクノロジーによる次世代薬物療法を目指して, 堤康央, 生命とくすり, Vol. 18,, No. 6, 2002
Site-specific pegylation using phage display system, Yoko Miyamoto,Yasuo Tsutsumi,Shinsaku Nakagawa,Tadanori Mayumi, Drug Delivery System, Vol. 17, No. 5, p. 427-434, 2002
PPAR gamma-gene therapy for inflammatory bowel disease., XIVth World Congress of Pharmacology, San Francisco, CA, 2002
A NOVEL DIRECTION FOR GENE THERAPY OF INFLAMMATORY BOWEL DISEASE (IBD)., Controlled Release Society's 29th Annual Meeting, Seoul, Korea, 2002
Application of DDS for gene therapy., Controlled Release Society's 29th Annual Meeting, Seoul, Korea, 2002
TES-23 : Tumor vascular targeting therapy using tumor-endothelium specific monoclonal antibody (TES-23)., FIRST INTERNATIONAL CONFERENCE ON VASCULAR TARGETING, Boston (U.S.A.), 2002
Direct introduction of macromolecules into living cells using fusogenic liposome., International Conference Particles 2002, Orlando, USA,, 2002
Direct introduction of nanoparticles into cytoplasm of living cells using fusogenic liposomes. The 1st Korea-Japan Joint Symposium on Drug Delivery and Therapy., Soul National Univ., 2002
Y. Yamamoto, Y. Tsutsumi, T. Mayumi Molecular design of bioconjugated cell adhesion peptide with a water-soluble polymeric modifier for enhancement of antimetastatic effect., Current Drug Targets, Vol. 3, 123-130, 2002
R. Suzuki, Y. Yoshioka, E. Kitano, T. Yoshioka, H. Oka, T. Okamoto, N. Okada, Y. Tsutsumi, S. Nakagawa, J. Miyazaki, H. Kitamura, T. Mayumi Development of a novel cytomedical treatment that can protect entrapped cells from host humoral immunity., Cell Transplant., Vol. 11, 787-797, 2002
J. Kunisawa, I. Takahashi, A. Okudaira, T. Hiroi, K. Katayama, T. Ariyama, Y. Tsutsumi, S. Nakagawa, H. Kiyono, T. Mayumi Lack of antigen-specific immune responses in anti-IL-7 receptor  chain antibody-treated Peyer’s path-null mice following intesti・・・, Eur. J. Immunol., Vol. 32, 2347-2355, 2002
Tumor vascular targeting therapy using tumor-endothelium specific monoclonal antibody(TES-23), FIRSAT INTERNATIONAL CONFERENCE ON VASCULAR TARGETING, 2002
Construction and evaluation of phage-displayed naive antibody libraries derived from human, mouse and rabbit, 29th Annual Meeting of the Controlled Release Society, 2002
膜融合リポソーム(FL)と小胞体挿入配列を用いたMHC class I提示経路への効率的抗原送達, 林哲,脇田久嗣,堤康央,藤原大美,浜岡利之,中川晋作,真弓忠範, 日本免疫学会総会・学術集会記録, Vol. 31, 2001/10/31
DDSの開発と臨床応用 DDSの免疫療法ワクチン開発とDDS, 林哲,国沢純,堤康央,中川晋作,真弓忠範, 分子がん治療, (株)先端医学社, Vol. 2, No. 3, p. 197-204, 2001/08/01
Sendai virus fusion protein-mediates simultaneous induction of MHC class I/II-dependent mucosal and systemic immune responses via the nasopharyngeal-associated lymphoreticular tissue immune system, J Kunisawa,T Nakanishi,Takahashi, I,A Okudaira,Y Tsutsumi,K Katayama,S Nakagawa,H Kiyono,T Mayumi, JOURNAL OF IMMUNOLOGY, AMER ASSOC IMMUNOLOGISTS, Vol. 167, No. 3, p. 1406-1412, 2001/08
膜融合リポソームによるヘルパーT細胞の活性化とその封入抗原特異的CTL誘導への影響, 今井大介,林哲,脇田久嗣,堤康央,中川晋作,真弓忠範, Drug Delivery System, 日本DDS学会, Vol. 16, No. 4, p. 353-353, 2001/07/10
薬物治療の最適化を充たす次世代バイオコンジュゲートDDSの確立に向けて, 山本陽子,鎌田春彦,鎌田恵子,堤康央,中川晋作,真弓忠範, Drug Deliv Syst, 日本DDS学会, Vol. 16, No. 4, p. 350-350, 2001/07/10
上皮細胞に対するセンダイウイルス並びに膜融合リポソームのMHC class II分子発現増強メカニズムに関する検討, 有山輝子,国沢純,高橋一郎,形山和史,増田幸史,堤康央,中川晋作,清野宏,真弓忠範, Drug Delivery System, Vol. 16, No. 4, 2001/07/10
細胞性製剤への抗補体作用付与による液性免疫隔離に関する基礎的検討, 岡本貴行,吉岡靖雄,鈴木亮,岡田直貴,北野悦子,北村肇,岡田秀親,堤康央,中川晋作,真弓忠範, Drug Delivery System, 日本DDS学会, Vol. 16, No. 4, p. 337-337, 2001/07
ファイバーミュータントアデノウイルスベクターにより抗原遺伝子導入した樹状細胞の免疫学的機能評価, 斎藤友美,岡田直貴,飯山さやか,津田貴司,松原亜沙子,森直樹,水口裕之,早川尭夫,堤康央,中川晋作, Drug Delivery System, 日本DDS学会, Vol. 16, No. 4, p. 307-307, 2001/07
Lowering the isoelectric point of the Fv portion of recombinant immunotoxins leads to decreased nonspecific animal toxicity without affecting antitumor activity, M Onda,S Nagata,Y Tsutsumi,JJ Vincent,QC Wang,RJ Kreitman,B Lee,Pastan, I, CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, Vol. 61, No. 13, p. 5070-5077, 2001/07
腎指向性修飾高分子の特性評価, 鎌田恵子,山本陽子,鎌田春彦,堤康央,中川晋作,真弓忠範, 薬剤学, (公社)日本薬剤学会, Vol. 61, No. Supplement, p. 214-214, 2001/03/05
体液性免疫隔離能を付与した細胞性製剤の開発, 鈴木亮,吉岡靖雄,岡本貴行,岡田直貴,宮崎純一,堤康央,中川晋作,真弓忠範, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 121st, No. 3, p. 124-124, 2001/03/05
腎指向性修飾高分子の特性評価バイオコンジュゲート化DDSへの応用に向けて, 鎌田恵子,山本陽子,鎌田春彦,堤康央,中川晋作,真弓忠範, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 121st, No. 3, p. 125-125, 2001/03/05
液性免疫隔離能を有する細胞性製剤の設計, 吉岡靖雄,鈴木亮,岡本貴行,岡田直貴,北野悦子,北村肇,堤康央,中川晋作,真弓忠範, 薬剤学, Vol. 61, No. Supplement, p. 110-110, 2001/03/05
血管内皮細胞を腫瘍への薬物キャリアとして用いるための基礎的検討, 渡邉将規,小泉桂一,山本陽子,小林恭子,谷洋一,堤康央,中川晋作,真弓忠範, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 121年会, No. 3, p. 131-131, 2001/03
Lowering the isoelectric point of the Fv portion of recombinant immunotoxins leads to decreased non-specific animal toxicity without affecting antitumor activity, M Onda,S Nagata,Y Tsutsumi,JJ Vincent,QC Wang,RJ Kreitman,BK Lee,Pastan, I, FASEB JOURNAL, FEDERATION AMER SOC EXP BIOL, Vol. 15, No. 4, p. A534-A534, 2001/03
Cytotoxicity of antiosteosarcoma recombinant immunotoxins composed of TP-3 Fv fragments and a truncated Pseudomonas exotoxin A, M Onda,T Olafsen,Y Tsutsumi,OS Bruland,Pastan, I, JOURNAL OF IMMUNOTHERAPY, LIPPINCOTT WILLIAMS & WILKINS, Vol. 24, No. 2, p. 144-150, 2001/03
Cytotoxicity of antiosteosarcoma recombinant immunotoxins composed of TP-3 Fv fragments and a truncated Pseudomonas exotoxin A, M Onda,T Olafsen,Y Tsutsumi,OS Bruland,Pastan, I, JOURNAL OF IMMUNOTHERAPY, LIPPINCOTT WILLIAMS & WILKINS, Vol. 24, No. 2, p. 144-150, 2001/03
Selective enhancement of thrombopoietic activity of PEGylated interleukin 6 by a simple procedure using a reversible amino-protective reagent, S Tsunoda,T Ishikawa,M Watanabe,H Kamada,Y Yamamoto,Y Tsutsumi,T Hirano,T Mayumi, BRITISH JOURNAL OF HAEMATOLOGY, BLACKWELL SCIENCE LTD, Vol. 112, No. 1, p. 181-188, 2001/01
DDSの免疫療法:ワクチン開発とDDS, 林哲,國澤純,堤康央,中川晋作,真弓忠範, 分子がん治療, Vol. 2, No. 3, p. 41-48, 2001
DDS研究の昨今, 堤康央, Pharm. Tech. Jpn., Vol. 17, p. 60-65, 2001
癌ミサイル療法の現状, 堤康央, Drug Delivery System (DDS), Vol. 16, p. 50-51, 2001
Selective enhancement of thrombopoietic activity of PEGylated interleukin 6 by a simple procedure using a reversible amino-protective reagent, S Tsunoda,T Ishikawa,M Watanabe,H Kamada,Y Yamamoto,Y Tsutsumi,T Hirano,T Mayumi, BRITISH JOURNAL OF HAEMATOLOGY, BLACKWELL SCIENCE LTD, Vol. 112, No. 1, p. 181-188, 2001/01
The recent Drug Delivery System, Pharm. Tech. Jpn., Vol. 17, p. 60-65, 2001
Tumor missile therapy, Drug Delivery System, Vol. 16, p. 50-51, 2001
Effective cancer targeting using an anti-tumor tissue vascular endothelium-specific monoclonal antibody (TES-23), Y Wakai,J Matsui,K Koizumi,S Tsunoda,H Makimoto,Ohizumi, I,K Taniguchi,S Kaiho,H Saito,N Utoguchi,Y Tsutsumi,S Nakagawa,Y Ohsugi,T Mayumi, JAPANESE JOURNAL OF CANCER RESEARCH, BUSINESS CENTER ACADEMIC SOCIETIES JAPAN, Vol. 91, No. 12, p. 1319-1325, 2000/12
Inhibition of TNF-alpha produced by Kupffer cells protects against the nonspecific liver toxicity of immunotoxin anti-Tac(Fv)-PE38, LMB-2, M Onda,M Willingham,QC Wang,RJ Kreitman,Y Tsutsumi,S Nagata,Pastan, I, JOURNAL OF IMMUNOLOGY, AMER ASSOC IMMUNOLOGISTS, Vol. 165, No. 12, p. 7150-7156, 2000/12
Inhibition of TNF-alpha produced by Kupffer cells protects against the nonspecific liver toxicity of immunotoxin anti-Tac(Fv)-PE38, LMB-2, M Onda,M Willingham,QC Wang,RJ Kreitman,Y Tsutsumi,S Nagata,Pastan, I, JOURNAL OF IMMUNOLOGY, AMER ASSOC IMMUNOLOGISTS, Vol. 165, No. 12, p. 7150-7156, 2000/12
Effective cancer targeting using an anti-tumor tissue vascular endothelium-specific monoclonal antibody (TES-23), Y Wakai,J Matsui,K Koizumi,S Tsunoda,H Makimoto,Ohizumi, I,K Taniguchi,S Kaiho,H Saito,N Utoguchi,Y Tsutsumi,S Nakagawa,Y Ohsugi,T Mayumi, JAPANESE JOURNAL OF CANCER RESEARCH, BUSINESS CENTER ACADEMIC SOCIETIES JAPAN, Vol. 91, No. 12, p. 1319-1325, 2000/12
Inhibition of TNF alpha produced by Kupffer cells protects against the liver toxicity of immunotoxin anti-Tac(Fv)-PE38., M Onda,M Willingham,QC Wang,RJ Kreitman,Y Tsutsumi,S Nagata,Pastan, I, BLOOD, AMER SOC HEMATOLOGY, Vol. 96, No. 11, p. 291B-291B, 2000/11
Antitumor activity of tumor necrosis factor-alpha conjugated with polyvinylpyrrolidone on solid tumors in mice, H Kamada,Y Tsutsumi,Y Yamamoto,T Kihira,Y Kaneda,Y Mu,H Kodaira,S Tsunoda,S Nakagawa,T Mayumi, CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, Vol. 60, No. 22, p. 6416-6420, 2000/11
Antitumor activity of tumor necrosis factor-alpha conjugated with polyvinylpyrrolidone on solid tumors in mice, H Kamada,Y Tsutsumi,Y Yamamoto,T Kihira,Y Kaneda,Y Mu,H Kodaira,S Tsunoda,S Nakagawa,T Mayumi, CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, Vol. 60, No. 22, p. 6416-6420, 2000/11
Characterization of mucoadhesive microspheres for the induction of mucosal and systemic immune responses, Jun Kunisawa,Akiko Okudaira,Yasuo Tsutusmi,Ichiro Takahashi,Tsuyoshi Nakanishi,Hiroshi Kiyono,Tadanori Mayumi, Vaccine, Vol. 19, No. 4-5, p. 589-594, 2000/10/15
Characterization of mucoadhesive microspheres for the induction of mucosal and systemic immune responses, Jun Kunisawa,Akiko Okudaira,Yasuo Tsutusmi,Ichiro Takahashi,Tsuyoshi Nakanishi,Hiroshi Kiyono,Tadanori Mayumi, Vaccine, Vol. 19, No. 4-5, p. 589-594, 2000/10/15
Human tumor necrosis factor-alpha mutant RGD-V29 (F4614) shows potent antitumor activity and reduced toxicity against human tumor xenografted nude mice, K Kuroda,K Miyata,F Fujita,M Koike,M Fujita,M Nomura,S Nakagawa,Y Tsutsumi,T Kawagoe,Y Mitsuishi,T Mayumi, CANCER LETTERS, ELSEVIER SCI IRELAND LTD, Vol. 159, No. 1, p. 33-41, 2000/10
Human tumor necrosis factor-alpha mutant RGD-V29 (F4614) shows potent antitumor activity and reduced toxicity against human tumor xenografted nude mice, K Kuroda,K Miyata,F Fujita,M Koike,M Fujita,M Nomura,S Nakagawa,Y Tsutsumi,T Kawagoe,Y Mitsuishi,T Mayumi, CANCER LETTERS, ELSEVIER SCI IRELAND LTD, Vol. 159, No. 1, p. 33-41, 2000/10
Molecular design of polyvinylpyrrolidone-conjugated interleukin-6 for enhancement of in vivo thrombopoietic activity in mice, S Tsunoda,H Kamada,Y Yamamoto,T Ishikawa,J Matsui,K Koizumi,Y Kaneda,Y Tsutsumi,Y Ohsugi,T Hirano,T Mayumi, JOURNAL OF CONTROLLED RELEASE, ELSEVIER SCIENCE BV, Vol. 68, No. 3, p. 335-341, 2000/09
Molecular design of polyvinylpyrrolidone-conjugated interleukin-6 for enhancement of in vivo thrombopoietic activity in mice, S Tsunoda,H Kamada,Y Yamamoto,T Ishikawa,J Matsui,K Koizumi,Y Kaneda,Y Tsutsumi,Y Ohsugi,T Hirano,T Mayumi, JOURNAL OF CONTROLLED RELEASE, ELSEVIER SCIENCE BV, Vol. 68, No. 3, p. 335-341, 2000/09
Growth inhibition of human leukemia HL-60 cells by an antisense phosphodiester oligonucleotide encapsulated into fusogenic liposomes, M Kondoh,T Matsuyama,R Suzuki,H Mizuguchi,T Nakanishi,S Nakagawa,Y Tsutsumi,M Nakanishi,M Sato,T Mayumi, BIOLOGICAL & PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOC JAPAN, Vol. 23, No. 8, p. 1011-1013, 2000/08
Growth inhibition of human leukemia HL-60 cells by an antisense phosphodiester oligonucleotide encapsulated into fusogenic liposomes, M Kondoh,T Matsuyama,R Suzuki,H Mizuguchi,T Nakanishi,S Nakagawa,Y Tsutsumi,M Nakanishi,M Sato,T Mayumi, BIOLOGICAL & PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOC JAPAN, Vol. 23, No. 8, p. 1011-1013, 2000/08
Association of CD44 with OTS-8 in tumor vascular endothelial cells, Iwao Ohizumi,Naoki Harada,Kenji Taniguchi,Yasuo Tsutsumi,Shinsaku Nakagawa,Shin Ichi Kaiho,Tadanori Mayumi, Biochimica et Biophysica Acta - Molecular Cell Research, Vol. 1497, 197-203/,, No. 2, p. 197-203, 2000/07/21
Site-specific chemical modification with polyethylene glycol of recombinant immunotoxin anti-Tac(Fv)-PE38 (LMB-2) improves antitumor activity and reduces animal toxicity and immunogenicity, Y Tsutsumi,M Onda,S Nagata,B Lee,RJ Kreitman,Pastan, I, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, NATL ACAD SCIENCES, Vol. 97, No. 15, p. 8548-8553, 2000/07
Site-specific chemical modification with polyethylene glycol of recombinant immunotoxin anti-Tac(Fv)-PE38 (LMB-2) improves antitumor activity and reduces animal toxicity and immunogenicity, Y Tsutsumi,M Onda,S Nagata,B Lee,RJ Kreitman,Pastan, I, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, NATL ACAD SCIENCES, Vol. 97, No. 15, p. 8548-8553, 2000/07
Fusogenic liposomes efficiently deliver exogenous antigen through the cytoplasm into the MHC class I processing pathway, T Nakanishi,A Hayashi,J Kunisawa,Y Tsutsumi,K Tanaka,Y Yashiro-Ohtani,M Nakanishi,H Fujiwara,T Hamaoka,T Mayumi, EUROPEAN JOURNAL OF IMMUNOLOGY, WILEY-V C H VERLAG GMBH, Vol. 30, No. 6, p. 1740-1747, 2000/06
Molecular cloning and characterization of antigens expressed on rat tumor vascular endothelial cells, K Taniguchi,N Harada,Ohizumi, I,M Kinoshita,Y Tsutsumi,S Nakagawa,S Kaiho,T Mayumi, INTERNATIONAL JOURNAL OF CANCER, WILEY-LISS, Vol. 86, No. 6, p. 799-805, 2000/06
Fusogenic liposomes efficiently deliver exogenous antigen through the cytoplasm into the MHC class I processing pathway, T Nakanishi,A Hayashi,J Kunisawa,Y Tsutsumi,K Tanaka,Y Yashiro-Ohtani,M Nakanishi,H Fujiwara,T Hamaoka,T Mayumi, EUROPEAN JOURNAL OF IMMUNOLOGY, WILEY-V C H VERLAG GMBH, Vol. 30, No. 6, p. 1740-1747, 2000/06
Molecular cloning and characterization of antigens expressed on rat tumor vascular endothelial cells, K Taniguchi,N Harada,Ohizumi, I,M Kinoshita,Y Tsutsumi,S Nakagawa,S Kaiho,T Mayumi, INTERNATIONAL JOURNAL OF CANCER, WILEY-LISS, Vol. 86, No. 6, p. 799-805, 2000/06
可溶性タンパク抗原経口免疫における消化管内環境の影響, 奥平章子,国沢純,高橋一郎,形山和史,堤康央,中川晋作,清野宏,真弓忠範, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 120th, No. 3, p. 71-71, 2000/03/05
細胞性免疫誘導能を指標にした膜融合リポソームの経鼻ワクチンキャリアーとしての有用性評価, 国沢純,奥平章子,中西剛,堤康央,形山和史,中川晋作,真弓忠範,高橋一郎,清野宏, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 120th, No. 4, p. 18-18, 2000/03/05
細胞性製剤の体液性免疫隔離 (1) 細胞固定化担体の補体透過性抑制効果, 鈴木亮,岡宏明,吉岡靖雄,岡田直貴,堤康央,中川晋作,早川尭夫,宮崎純一,真弓忠範, 日本薬学会年会要旨集, Vol. 120th, No. 2, 2000/03/05
DNAデリバリーを応用した経口コレラワクチンの設計, 形山和史,国沢純,奥平章子,堤康央,中川晋作,真弓忠範,権美那,高橋一郎,清野宏, 日本薬学会年会要旨集, Vol. 120th, No. 2, 2000/03/05
細胞性製剤の体液性免疫隔離 (2) 補体失活能を有する新規細胞固定化担体の開発, 岡宏明,鈴木亮,吉岡靖雄,岡田直貴,堤康央,中川晋作,早川尭夫,宮崎純一,真弓忠範, 日本薬学会年会要旨集, Vol. 120th, No. 2, 2000/03/05
腫よう血管に対するTargeting能を付与した血管内皮細胞の基礎的検討, 小泉桂一,渡辺将規,鎌田春彦,山本陽子,石川智世至,堤康央,中川晋作,真弓忠範,谷洋一, 日本薬学会年会要旨集, Vol. 120th, No. 2, 2000/03/05
膜融合リポソームの癌遺伝子免疫療法への応用, 今津進,林和行,津田育弘,堤康央,中川晋作,真弓忠範,早川尭夫, 日本薬学会年会要旨集, Vol. 120th, No. 2, 2000/03/05
腎指向性修飾高分子の開発とその特性評価, 山本陽子,鎌田春彦,佐藤恵子,石川智世至,西端俊秀,松田貴久,小平浩史,堤康央,中川晋作,真弓忠範, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 120年会, No. 4, p. 21-21, 2000/03
Recognition of human activated CD44 by tumor vasculature-targeted antibody, K Taniguchi,N Harada,Ohizumi, I,Y Tsutsumi,S Nakagawa,S Kaiho,T Mayumi, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC, Vol. 269, No. 3, p. 671-675, 2000/03
Targeting therapy using a monoclonal antibody against tumor vascular endothelium, S Tsunoda,Y Tsutsumi,S Nakagawa,T Mayumi, YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, PHARMACEUTICAL SOC JAPAN, Vol. 120, No. 3, p. 256-264, 2000/03
Targeting therapy using a monoclonal antibody against tumor vascular endothelium, S Tsunoda,Y Tsutsumi,S Nakagawa,T Mayumi, YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, PHARMACEUTICAL SOC JAPAN, Vol. 120, No. 3, p. 256-264, 2000/03
Recognition of human activated CD44 by tumor vasculature-targeted antibody, K Taniguchi,N Harada,Ohizumi, I,Y Tsutsumi,S Nakagawa,S Kaiho,T Mayumi, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC, Vol. 269, No. 3, p. 671-675, 2000/03
In vitro remodeling of tumor vascular endothelial cells using conditioned medium from various tumor cells and their sensitivity to TNF-alpha, H Kamada,Y Tsutsumi,T Kihira,S Tsunoda,Y Yamamoto,T Mayumi, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC, Vol. 268, No. 3, p. 809-813, 2000/02
In vitro remodeling of tumor vascular endothelial cells using conditioned medium from various tumor cells and their sensitivity to TNF-alpha, H Kamada,Y Tsutsumi,T Kihira,S Tsunoda,Y Yamamoto,T Mayumi, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC, Vol. 268, No. 3, p. 809-813, 2000/02
Conjugation of a laminin-related antimetastatic peptide with chitosan.(Part 3), Nishiyama Y,Yoshikawa T,Ohara N,Mizushima Y,Kurita K,Hojo K,Kawasaki K,Kamada H,Tsutsumi Y,Mayumi T,Shimojo M, The Japanese Peptide Society., p. 247-250, 2000
Association of CD44 with OTS-8 in tumor vascular endothelial cells, Ohizumi I,Harada N,Taniguchi K,Tsutsumi Y,Nakagawa S,Kaiho S,Mayumi T, Biochim. Biophys. Acta., Vol. 1497, No. 2, p. 197-203, 2000
Facile synthesis of a chitosan hybrid of a laminin-related peptide and its antimetastatic effect in mice, K Hojo,M Maeda,Y Mu,H Kamada,Y Tsutsumi,Y Nishiyama,T Yoshikawa,K Kurita,LH Block,T Mayumi,K Kawasaki, JOURNAL OF PHARMACY AND PHARMACOLOGY, ROYAL PHARMACEUTICAL SOC GREAT BRITAIN, Vol. 52, No. 1, p. 67-73, 2000/01
Preferential activity of wild-type and mutant tumor necrosis factor-alpha against tumor-derived endothelial-like cells, K Kuroda,K Miyata,Y Tsutsumi,S Tsunoda,K Nishimura,Y Mitsuishi,S Nakagawa,T Mayumi, JAPANESE JOURNAL OF CANCER RESEARCH, ELSEVIER SCI IRELAND LTD, Vol. 91, No. 1, p. 59-67, 2000/01
Conjugation of a Laminin-Related Antimetastatic Peptide with Chitosan.(Part 3), The Japanese Peptide Society., Vol. 2000, p. 247-250, 2000
Facile synthesis of a chitosan hybrid of a laminin-related peptide and its antimetastatic effect in mice, K Hojo,M Maeda,Y Mu,H Kamada,Y Tsutsumi,Y Nishiyama,T Yoshikawa,K Kurita,LH Block,T Mayumi,K Kawasaki, JOURNAL OF PHARMACY AND PHARMACOLOGY, ROYAL PHARMACEUTICAL SOC GREAT BRITAIN, Vol. 52, No. 1, p. 67-73, 2000/01
Direct delivery of exogenous soluble antigens to the MHC class (]G0001[) antigen presentation pathway by fusogenic liposomes., Millennial World Congress of Pharmaceutical Sciences (FIP), 2000
Cytomedical therapy for diabetes mellitus using microencapsulated pancreatic beta cell line with glucose sensor., Millennial World Congress of Pharmaceutical Sciences (FIP), 2000
Development of the novel cytomedical device that can protect against host's humoral immunity., Millennial World Congress of Pharmaceutical Sciences (FIP), 2000
The development of a new drug delivery system : the controlled release of drugs into cytoplasm from nanospheres introduced in the cell by fusogenic liposomes., Millennial World Congress of Pharmaceutical Sciences (FIP), 2000
Novel Fusogenic Liposome Induce MHC Class (]G0002[) Mediated Helper T cell and Humoral Immune Responses at Mucosal and Systemic Site., Millennial World Congress of Pharmaceutical Sciences (FIP), 2000
Development of a novel method for the bioconjugation of cytokines using a reversible amino - protective reagent., Millennial World Congress of Pharmaceutical Sciences (FIP), 2000
Association of CD44 with OTS-8 in tumor vascular endothelial cells., Biochim - Biophys - Acta., Vol. 1497, No. 2, p. 197-203, 2000
Preferential activity of wild-type and mutant tumor necrosis factor-alpha against tumor-derived endothelial-like cells, K Kuroda,K Miyata,Y Tsutsumi,S Tsunoda,K Nishimura,Y Mitsuishi,S Nakagawa,T Mayumi, JAPANESE JOURNAL OF CANCER RESEARCH, ELSEVIER SCI IRELAND LTD, Vol. 91, No. 1, p. 59-67, 2000/01
Specific binding of TES-23 antibody to tumour vascular endothelium in mice, rats and human cancer tissue: a novel drug carrier for cancer targeting therapy, S Tsunoda,Ohizumi, I,J Matsui,K Koizumi,Y Wakai,H Makimoto,Y Tsutsumi,N Utoguchi,K Taniguchi,H Saito,N Harada,Y Ohsugi,T Mayumi, BRITISH JOURNAL OF CANCER, CHURCHILL LIVINGSTONE, Vol. 81, No. 7, p. 1155-1161, 1999/12
Specific binding of TES-23 antibody to tumour vascular endothelium in mice, rats and human cancer tissue: a novel drug carrier for cancer targeting therapy, S Tsunoda,Ohizumi, I,J Matsui,K Koizumi,Y Wakai,H Makimoto,Y Tsutsumi,N Utoguchi,K Taniguchi,H Saito,N Harada,Y Ohsugi,T Mayumi, BRITISH JOURNAL OF CANCER, CHURCHILL LIVINGSTONE, Vol. 81, No. 7, p. 1155-1161, 1999/12
Specific binding of TES-23 antibody to tumour vascular endothelium in mice, rats and human cancer tissue: a novel drug carrier for cancer targeting therapy, S Tsunoda,Ohizumi, I,J Matsui,K Koizumi,Y Wakai,H Makimoto,Y Tsutsumi,N Utoguchi,K Taniguchi,H Saito,N Harada,Y Ohsugi,T Mayumi, BRITISH JOURNAL OF CANCER, CHURCHILL LIVINGSTONE, Vol. 81, No. 7, p. 1155-1161, 1999/12
Bioconjugation of laminin-related peptide YIGSR with polyvinyl pyrrolidone increases its antimetastatic effect due to a longer plasma half-life, Y Mu,H Kamada,H Kodaira,K Sato,Y Tsutsumi,M Maeda,K Kawasaki,M Nomizu,Y Yamada,T Mayumi, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC, Vol. 264, No. 3, p. 763-767, 1999/11
22C-09-1 A novel CTL vaccine delivery system using fusogenic liposomes., NAKANISHI Tsuyoshi,HAYASHI Akira,KUNISAWA Jun,TSUTSUMI Yasuo,TANAKA Keiichi,MAYUMI Tadanori, Journal of toxicological sciences, The Japanese Society of Toxicology, Vol. 24, No. 4, p. 361-361, 1999/10/26
Suppression of solid tumor growth by a monoclonal antibody against tumor vasculature in rats: Involvement of intravascular thrombosis and fibrinogenesis, Ohizumi, I,K Taniguchi,H Saito,H Kawata,S Tsunoda,H Makimoto,Y Wakai,Y Tsutsumi,S Nakagawa,N Utoguchi,S Kaiho,Y Ohsugi,T Mayumi, INTERNATIONAL JOURNAL OF CANCER, WILEY-LISS, Vol. 82, No. 6, p. 853-859, 1999/09
Suppression of solid tumor growth by a monoclonal antibody against tumor vasculature in rats: Involvement of intravascular thrombosis and fibrinogenesis, Ohizumi, I,K Taniguchi,H Saito,H Kawata,S Tsunoda,H Makimoto,Y Wakai,Y Tsutsumi,S Nakagawa,N Utoguchi,S Kaiho,Y Ohsugi,T Mayumi, INTERNATIONAL JOURNAL OF CANCER, WILEY-LISS, Vol. 82, No. 6, p. 853-859, 1999/09
A novel vaccine delivery system using immunopotentiating fusogenic liposomes, Akira Hayashi,Tsuyoshi Nakanishi,Jun Kunisawa,Masuo Kondoh,Susumu Imazu,Yasuo Tsutsumi,Keiichi Tanaka,Hiromi Fujiwara,Toshiyuki Hamaoka,Tadanori Mayumi, Biochemical and Biophysical Research Communications, Academic Press Inc., Vol. 261, No. 3, p. 824-828, 1999/08/11
A novel vaccine delivery system using immunopotentiating fusogenic liposomes, Akira Hayashi,Tsuyoshi Nakanishi,Jun Kunisawa,Masuo Kondoh,Susumu Imazu,Yasuo Tsutsumi,Keiichi Tanaka,Hiromi Fujiwara,Toshiyuki Hamaoka,Tadanori Mayumi, Biochemical and Biophysical Research Communications, Academic Press Inc., Vol. 261, No. 3, p. 824-828, 1999/08/11
Positively charged liposome functions as an efficient immunoadjuvant in inducing cell-mediated immune response to soluble proteins, T Nakanishi,J Kunisawa,A Hayashi,Y Tsutsumi,K Kubo,S Nakagawa,M Nakanishi,K Tanaka,T Mayumi, JOURNAL OF CONTROLLED RELEASE, ELSEVIER SCIENCE BV, Vol. 61, No. 1-2, p. 233-240, 1999/08
Positively charged liposome functions as an efficient immunoadjuvant in inducing cell-mediated immune response to soluble proteins, T Nakanishi,J Kunisawa,A Hayashi,Y Tsutsumi,K Kubo,S Nakagawa,M Nakanishi,K Tanaka,T Mayumi, JOURNAL OF CONTROLLED RELEASE, ELSEVIER SCIENCE BV, Vol. 61, No. 1-2, p. 233-240, 1999/08
細胞内徐放による細胞質内遺伝子発現コントロールシステムの開発, 形山和史,中川哲彦,米屋由理,中野里佐子,堤康央,中川晋作,中西真人,早川尭夫,真弓忠範, Drug Delivery System, 日本DDS学会, Vol. 14, No. 4, p. 324-324, 1999/07
Tumor vascular targeting using a tumor-tissue endothelium-specific monoclonal antibody as an effective strategy for cancer chemotherapy, H Makimoto,K Koizumi,S Tsunoda,Y Wakai,J Matsui,Y Tsutsumi,S Nakagawa,Ohizumi, I,K Taniguchi,H Saito,N Utoguchi,Y Ohsugi,T Mayumi, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC, Vol. 260, No. 2, p. 346-350, 1999/07
Enhanced antitumor potency of polyethylene glycolylated tumor necrosis factor-alpha: A novel polymer-conjugation technique with a reversible amino-protective reagent, S Tsunoda,T Ishikawa,Y Yamamoto,H Kamada,K Koizumi,J Matsui,Y Tsutsumi,T Hirano,T Mayumi, JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS, Vol. 290, No. 1, p. 368-372, 1999/07
Enhanced antitumor potency of polyethylene glycolylated tumor necrosis factor-alpha: A novel polymer-conjugation technique with a reversible amino-protective reagent, S Tsunoda,T Ishikawa,Y Yamamoto,H Kamada,K Koizumi,J Matsui,Y Tsutsumi,T Hirano,T Mayumi, JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS, Vol. 290, No. 1, p. 368-372, 1999/07
Tumor vascular targeting using a tumor-tissue endothelium-specific monoclonal antibody as an effective strategy for cancer chemotherapy, H Makimoto,K Koizumi,S Tsunoda,Y Wakai,J Matsui,Y Tsutsumi,S Nakagawa,Ohizumi, I,K Taniguchi,H Saito,N Utoguchi,Y Ohsugi,T Mayumi, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC, Vol. 260, No. 2, p. 346-350, 1999/07
Molecular design of conjugated tumor necrosis factor-alpha: Synthesis and characteristics of polyvinyl pyrrolidone modified tumor necrosis factor-alpha, H Kamada,Y Tsutsumi,S Tsunoda,T Kihira,Y Kaneda,Y Yamamoto,S Nakagawa,Y Horisawa,T Mayumi, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC, Vol. 257, No. 2, p. 448-453, 1999/04
Molecular design of conjugated tumor necrosis factor-alpha: Synthesis and characteristics of polyvinyl pyrrolidone modified tumor necrosis factor-alpha, H Kamada,Y Tsutsumi,S Tsunoda,T Kihira,Y Kaneda,Y Yamamoto,S Nakagawa,Y Horisawa,T Mayumi, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC, Vol. 257, No. 2, p. 448-453, 1999/04
膜融合リポソームの細胞質内直接物質導入機構に関する基礎的検討, 米屋由理,今津進,林和行,堤康央,中川晋作,中西真人,早川尭夫,真弓忠範, 薬剤学: 生命とくすり, (公社)日本薬剤学会, Vol. 59, No. Suppl., p. 107-107, 1999/03/05
β-globin sequenceの付加に伴うT7細胞質内遺伝子発現系の改善, 中野里佐子,中川哲彦,水口裕之,形山和史,堤康央,久保一義,中川晋作,早川尭夫,中西真人,真弓忠範, 薬剤学: 生命とくすり, (公社)日本薬剤学会, Vol. 59, No. Suppl., p. 108-108, 1999/03/05
生理活性ペプチドの高分子ハイブリッド化DDS ポリスチレンマレイン酸によるラミニン関連細胞接着ペプチドのバイオコンジュゲーションとその癌転移抑制効果, 牟宇,鎌田春彦,金田喜久,山本陽子,小平浩史,角田慎一,堤康央,前田光子,川崎紘一,野水基義,山田吉彦,真弓忠範, Drug Delivery System, 日本DDS学会, Vol. 14, No. 2, p. 129-135, 1999/03
ラミニンγ1鎖関連ペプチドのポリエチレングリコール修飾, 須々木雄一,前田光子,川崎紘一,野水基義,山田吉彦,鎌田春彦,牟宇,堤康央,真弓忠範, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 119年会, No. 2, p. 183-183, 1999/03
膜融合リポソームのDNAワクチンベクターとしての基礎的検討, 今津進,林和行,中西剛,中川哲彦,堤康央,中川晋作,真弓忠範,中西真人,水口裕之,早川尭夫, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 119年会, No. 4, p. 17-17, 1999/03
異種補体抵抗性を有する細胞性製剤の開発に関する基礎的検討補体失活作用を付与した新規高分子担体の設計, 岡宏明,鈴木亮,吉岡竜伸,堤康央,中川晋作,真弓忠範,岡田直貴,早川尭夫, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 119年会, No. 4, p. 14-14, 1999/03
MIN6細胞を封入した細胞性製剤の糖尿病モデルラットへの適用細胞性製剤に対する異種動物免疫系の影響, 鈴木亮,岡宏明,吉岡竜伸,堤康央,中川晋作,真弓忠範,岡田直貴,早川尭夫,宮崎純一, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 119年会, No. 4, p. 15-15, 1999/03
mRNAを利用した新規細胞質内遺伝子発現系の開発, 中野里佐子,中川哲彦,形山和史,堤康央,久保一義,中川晋作,真弓忠範,中西真人,水口裕之,早川尭夫, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 119年会, No. 4, p. 17-17, 1999/03
新規修飾制御法を用いたバイオコンジュゲート化サイトカインの開発とその評価, 石川智世至,角田慎一,小泉桂一,松井順二,渡邉将規,山本陽子,堤康央,真弓忠範,平野隆, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 119年会, No. 4, p. 15-15, 1999/03
培養癌組織血管内皮細胞を用いた癌組織血管の特性評価, 松井順二,角田慎一,小泉桂一,石川智世至,渡邉将規,堤康央,真弓忠範, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 119年会, No. 4, p. 15-15, 1999/03
Regioselective conjugation of chitosan with a laminin-related peptide, Tyr-Ile-Gly-Ser-Arg, and evaluation of its inhibitory effect on experimental cancer metastasis, Y Nishiyama,T Yoshikawa,K Kurita,K Hojo,H Kamada,Y Tsutsumi,T Mayumi,K Kawasaki, CHEMICAL & PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOC JAPAN, Vol. 47, No. 3, p. 451-453, 1999/03
Prolongation of the effective duration of cytomedical therapy by re-injecting SK2 hybridoma cells microencapsulated within alginate-poly(L)lysine-alginate membranes into human interleukin-6 transgenic mice, H Miyamoto,N Okada,T Yoshioka,K Sakamoto,A Katsume,H Saito,Y Tsutsumi,K Kubo,S Nakagawa,Y Ohsugi,T Mayumi, BIOLOGICAL & PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOC JAPAN, Vol. 22, No. 3, p. 295-297, 1999/03
Regioselective conjugation of chitosan with a laminin-related peptide, Tyr-Ile-Gly-Ser-Arg, and evaluation of its inhibitory effect on experimental cancer metastasis, Y Nishiyama,T Yoshikawa,K Kurita,K Hojo,H Kamada,Y Tsutsumi,T Mayumi,K Kawasaki, CHEMICAL & PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOC JAPAN, Vol. 47, No. 3, p. 451-453, 1999/03
Prolongation of the effective duration of cytomedical therapy by re-injecting SK2 hybridoma cells microencapsulated within alginate-poly(L)lysine-alginate membranes into human interleukin-6 transgenic mice, H Miyamoto,N Okada,T Yoshioka,K Sakamoto,A Katsume,H Saito,Y Tsutsumi,K Kubo,S Nakagawa,Y Ohsugi,T Mayumi, BIOLOGICAL & PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOC JAPAN, Vol. 22, No. 3, p. 295-297, 1999/03
Bioconjugation of laminin peptide YIGSR with poly(styrene co-maleic acid) increases its antimetastatic effect on lung metastasis of B16-BL6 melanoma cells, Yu Mu,Haruhiko Kamada,Yoshihisa Kaneda,Yoko Yamamoto,Hiroshi Kodaira,Shin-Ichi Tsunoda,Yasuo Tsutsumi,Mistuko Maeda,Koichi Kawasaki,Motoyoshi Nomizu,Yoshihiko Yamada,Tadanori Mayumi, Biochemical and Biophysical Research Communications, Academic Press Inc., Vol. 255, No. 1, p. 75-79, 1999/02/05
Fusion of Sendai virus with liposome depends on only F protein, but not HN protein, H Mizuguchi,T Nakanishi,M Kondoh,T Nakagawa,M Nakanishi,T Matsuyama,Y Tsutsumi,S Nakagawa,T Mayumi, VIRUS RESEARCH, ELSEVIER SCIENCE BV, Vol. 59, No. 2, p. 191-201, 1999/02
Bioconjugation of laminin peptide YIGSR with poly(styrene co-maleic acid) increases its antimetastatic effect on lung metastasis of B16-BL6 melanoma cells, Y Mu,H Kamada,Y Kaneda,Y Yamamoto,H Kodaira,S Tsunoda,Y Tsutsumi,M Maeda,K Kawasaki,M Nomizu,Y Yamada,T Mayumi, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC, Vol. 255, No. 1, p. 75-79, 1999/02
Fusion of Sendai virus with liposome depends on only F protein, but not HN protein, H Mizuguchi,T Nakanishi,M Kondoh,T Nakagawa,M Nakanishi,T Matsuyama,Y Tsutsumi,S Nakagawa,T Mayumi, VIRUS RESEARCH, ELSEVIER SCIENCE BV, Vol. 59, No. 2, p. 191-201, 1999/02
Application of T7 expression system to a cytoplasmic gene expression using fusogenic liposomes, T. Nakagawa,H. Mizuguchi,R. Suzuki,R. Nakano,K. Katayama,Y. Tsutsumi,S. Nakagawa,T. Hayakawa,M. Nakanishi,T. Mayumi, Proceedings of the Controlled Release Society, p. 763-764, 1999/01/01
Preparation of a chitosan hybrid of an antimetastatic laminin-related peptide, Keiko Hojo,Mitsuko Maeda,Yu Mu,Haruhiko Kamada,Yasuo Tsutsumi,Yasuhiro Nishiyama,Tomoko Yoshikawa,Keisuke Kurita,Lawrence H. Block,Tadanori Mayumi,Koichi Kawasaki, Pharmacy and Pharmacology Communications, Pharmaceutical Press, Vol. 5, No. 4, p. 277-280, 1999
Bioconjugation of bioactive peptide: Synthetic peptide YIGSR conjugated with poly(styrene comaleic acid) enhanced its inhibitory effect on lung metastasis of B16BL6 melanoma cells, Yu Mu,Haruhiko Kamada,Yoshihisa Kaneda,Yoko Yamamoto,Hiroshi Kodaira,Shin-ichi Tsunoda,Motoyoshi Nomizu,Yasuo Tsutsumi,Tadanori Mayumi,Mitsuko Maeda,Koichi Kawasaki,Yoshihiko Yamada, Drug Delivery System, Vol. 14, No. 2, p. 129-135, 1999
DDSこの一年の進歩, 堤康央, 人工臓器, Vol. 28, No. 5, p. 666-668, 1999
抗体療法の現状と将来腫瘍組織血管内皮細胞に対するターゲッティング療法, 堤康央,真弓忠範, Biotherapy, Vol. 13, No. 10, p. 1038-1045, 1999
癌組織血管を標的とした抗体療法｢Tumor Vascular Targeting using tumor-tissue endothelium specific monoclonal antibody for effective cancer therapy｣, 堤康央,真弓忠範, 血液･免疫･腫瘍(メディカルレビュー社), Vol. 14, No. 4, p. 414-421, 1999
Novel Fusogenic Liposome Induce MHC class (]G0002[) mediated Mucosal and Systemic Helper T cell Responses., 1999
Bioconjugation of bioactive peptide: Synthetic peptide YIGSR conjugated with poly(styrene comaleic acid) enhanced its inhibitory effect on lung metastasis of B16BL6 melanoma cells, Yu Mu,Haruhiko Kamada,Yoshihisa Kaneda,Yoko Yamamoto,Hiroshi Kodaira,Shin-ichi Tsunoda,Motoyoshi Nomizu,Yasuo Tsutsumi,Tadanori Mayumi,Mitsuko Maeda,Koichi Kawasaki,Yoshihiko Yamada, Drug Delivery System, Vol. 14, No. 2, p. 129-135, 1999
Tumor Vascular Targeting Using Anti - Tumor Endothelium Specific Antibody, Biotherapy, Vol. 13, No. 10, p. 1038-1045, 1999
Advance of drug delivery system, Vol. 28, No. 5, p. 666-668, 1999
Tumor Vascular Targeting using tumor - tissue endothelium specific monoclonal antibody for effective cancer therapy., Blood - Immunity - Cancer, Vol. 14, No. 4, p. 414-421, 1999
Preparation of a chitosan hybrid of an antimetastatic laminin-related peptide, Keiko Hojo,Mitsuko Maeda,Yu Mu,Haruhiko Kamada,Yasuo Tsutsumi,Yasuhiro Nishiyama,Tomoko Yoshikawa,Keisuke Kurita,Lawrence H. Block,Tadanori Mayumi,Koichi Kawasaki, Pharmacy and Pharmacology Communications, Pharmaceutical Press, Vol. 5, No. 4, p. 277-280, 1999
Bioconjugation of bioactive peptide: Synthetic peptide YIGSR conjugated with poly(styrene comaleic acid) enhanced its inhibitory effect on lung metastasis of B16BL6 melanoma cells, Yu Mu,Haruhiko Kamada,Yoshihisa Kaneda,Yoko Yamamoto,Hiroshi Kodaira,Shin-ichi Tsunoda,Motoyoshi Nomizu,Yasuo Tsutsumi,Tadanori Mayumi,Mitsuko Maeda,Koichi Kawasaki,Yoshihiko Yamada, Drug Delivery System, Vol. 14, No. 2, p. 129-135, 1999
Tumor necrosis factor alpha-mediated tumor regression by the in vivo transfer of genes into the artery that leads to tumors, H Mizuguchi,T Nakagawa,S Toyosawa,M Nakanishi,S Imazu,T Nakanishi,Y Tsutsumi,S Nakagawa,T Hayakawa,N Ijuhin,T Mayumi, CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, Vol. 58, No. 24, p. 5725-5730, 1998/12
Tumor necrosis factor alpha-mediated tumor regression by the in vivo transfer of genes into the artery that leads to tumors, H Mizuguchi,T Nakagawa,S Toyosawa,M Nakanishi,S Imazu,T Nakanishi,Y Tsutsumi,S Nakagawa,T Hayakawa,N Ijuhin,T Mayumi, CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, Vol. 58, No. 24, p. 5725-5730, 1998/12
Preparation of Laminin γ1 Chain Related Peptide Poly (Ethylene Glycol) Hybrid, SUSUKI Yuichi,MAEDA Mitsuko,KAWASAKI Koichi,NOMIZU Motoyoshi,YAMADA Yoshihiko,KAMADA Haruhiko,MU Yu,TSUTSUMI Yasuo,MAYUMI Tadanori, Vol. 1998, p. 277-280, 1998/10/01
ラット腫瘍血管内皮細胞モノクローナル抗体の認識する抗原遺伝子のクローニング, 原田直樹,谷口健治,大泉厳雄,海宝晋一,角田慎一,堤康央,中川晋作,真弓忠範, 日本癌学会総会記事, 日本癌学会, Vol. 57回, p. 514-514, 1998/08
Identification of tumor vascular antigens by monoclonal antibodies prepared from rat-tumor-derived endothelial cells, Ohizumi, I,S Tsunoda,K Taniguchi,H Saito,K Esaki,K Koizumi,H Makimoto,Y Wakai,J Matsui,Y Tsutsumi,S Nakagawa,N Utoguchi,Y Ohsugi,T Mayumi, INTERNATIONAL JOURNAL OF CANCER, WILEY-LISS, Vol. 77, No. 4, p. 561-566, 1998/08
Amino acids and peptides - XXXIII. A bifunctional poly(ethylene glycol) hybrid of laminin-related peptides, M Maeda,K Kawasaki,Y Mu,H Kamada,Y Tsutsumi,TJ Smith,T Mayumi, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC, Vol. 248, No. 3, p. 485-489, 1998/07
Amino acids and peptides - XXXIII. A bifunctional poly(ethylene glycol) hybrid of laminin-related peptides, M Maeda,K Kawasaki,Y Mu,H Kamada,Y Tsutsumi,TJ Smith,T Mayumi, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC, Vol. 248, No. 3, p. 485-489, 1998/07
Conjugation of a Laminin-related Anti-metastatic Peptide with Chitosan, NISHIYAMA Y.,YOSHIKAWA T.,MORI T.,KURITA K.,HOJO K.,KAWASAKI K.,TSUTSUMI Y.,MAYUMI T., Vol. 4, No. 2, p. 218-219, 1998/05/15
抗原分子の生体内および細胞内動態制御による効果的な免疫反応の誘導 : 膜融合リポソームの抗原提示促進作用とアジュバント効果, 中西剛,國澤純,林哲,山内由紀枝,堤康央,中西真人,藤原大美,濱岡利之,真弓忠範, 薬剤学, Vol. 58, p. 54-54, 1998/03/05
水溶性高分子の動態特性評価に基づいたバイオコンジュゲート医薬品の分子設計理論の構築, 金田喜久,角田慎一,鎌田春彦,山本陽子,小平浩史,難波岳,堤康央,真弓忠範, 薬剤学, Vol. 58, p. 64-64, 1998/03/05
Amino acids and peptides. XXXI. Preparation of analogs of the laminin-related peptide YIGSR and their inhibitory effect on experimental metastasis, M Maeda,Y Izuno,K Kawasaki,Y Kaneda,Y Mu,Y Tsutsumi,S Nakagawa,T Mayumi, CHEMICAL & PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOC JAPAN, Vol. 46, No. 2, p. 347-350, 1998/02
Amino acids and peptides. XXXI. Preparation of analogs of the laminin-related peptide YIGSR and their inhibitory effect on experimental metastasis, M Maeda,Y Izuno,K Kawasaki,Y Kaneda,Y Mu,Y Tsutsumi,S Nakagawa,T Mayumi, CHEMICAL & PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOC JAPAN, Vol. 46, No. 2, p. 347-350, 1998/02
Cationization of Liposomal Surface Charge Enhances Adjuvant Effect of Liposomes for Tumor Vaccine, NAKANISHI TSUYOSHI,KUNISAWA JUN,HAYASHI AKIRA,TSUTSUMI YASUO,HAYAKAWA TAKAO,MAYUMI TADANORI, Vol. 58, No. 2, p. 59-68, 1998
Enhancement of liposomal adjuvant actions for tumor vaccines by increasing the degree of positive surface charge, Tsuyoshi Nakanishi,Jun Kunisawa,Akira Hayashi,Yasuo Tsutsumi,Tadanori Mayaumi,Takao Hayakawa, Drug Delivery System, Vol. 13, No. 3, p. 151-157, 1998
Fusogenic liposome functions as an efficient immunoadjuvant in inducing humoral immune-responses to soluble antigen, Jun Kunisawa,Tsuyoshi Nakanishi,Akira Hayashi,Yasuo Tsutsumi,Tadanori Mayumi,Takao Hayakawa, Drug Delivery System, Vol. 13, No. 1, p. 21-26, 1998
Fusogenic liposome directs an exogenous antigen into class I major histocompatibility complex antigen-presenting pathway, Tsuyoshi Nakanishi,Jun Kunisawa,Akira Hayashi,Yasuo Tsutsumi,Tadanori Mayumi,Takao Hayakawa, Drug Delivery System, Vol. 13, No. 1, p. 27-33, 1998
Possibility of cytomedical therapy for diabetes mellitus using microencapsulated pancreatic β cell line with glucose sensor, Tatsunobu Yoshioka,Naoki Okada,Hajime Miyamoto,Kayoko Sakamoto,Yasuo Tsutsumi,Skinsaku Nakagawa,Tadanori Mayumi,Jun-ichi Miyazaki, Drug Delivery System, Vol. 13, No. 2, p. 95-100, 1998
Optimum Bioconjugated TNF-α Selectively Enhances Antitumor Potency and Reduces Side Effects, YAMAMOTO YOKO,KANEDA YOSHIHISA,TSUNODA SHIN-ICHI,KAMADA HARUHIKO,KODAIRA HIROSHI,TSUTSUMI YASUO,ITO YUKO,HIRANO TAKASHI,MAYUMI TADANORI, Vol. 58, No. 1, p. 37-45, 1998
Antitumor activity of tumor necrosis factor alpha conjugated with divinyl ether and maleic anhydride copolymer on solid tumors in mice, Y Kaneda,Y Yamamoto,H Kamada,S Tsunoda,Y Tsutsumi,T Hirano,T Mayumi, CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, Vol. 58, No. 2, p. 290-295, 1998/01
ハイブリッド化生理活性蛋白質の分子設計理論と分子レベルのDDS製剤, 角田慎一,堤康央,真弓忠範, 日本臨床, Vol. 56, p. 21-26, 1998
Molecular design of bioconjugated bioactive proteins and its applocation for DDS, Vol. 56, p. 21-26, 1998
Monoclonal antibodies recognize antigens expressed on rat tumor vasculature, Int. J. Cancer, Vol. 77, p. 561-566, 1998
Cationization of liposome surface charge enhances adjuvant effect of liposomes for tumor vaccine, J. Pharm. Sci. Technol. Jpn., Vol. 58, p. 59-68, 1998
Enhancement of liposomal adjuvant actions for tumor vaccines by increasing the degree of positive surface charge, Tsuyoshi Nakanishi,Jun Kunisawa,Akira Hayashi,Yasuo Tsutsumi,Tadanori Mayaumi,Takao Hayakawa, Drug Delivery System, Vol. 13, No. 3, p. 151-157, 1998
Fusogenic liposome functions as an efficient immunoadjuvant in inducing humoral immune-responses to soluble antigen, Jun Kunisawa,Tsuyoshi Nakanishi,Akira Hayashi,Yasuo Tsutsumi,Tadanori Mayumi,Takao Hayakawa, Drug Delivery System, Vol. 13, No. 1, p. 21-26, 1998
Fusogenic liposome directs an exogenous antigen into class Imajour histcompatibility complex antigen-presenting pathway, Drug Delivery System, Vol. 13, No. 1, p. 27-33, 1998
Possibility of cytomedical therapy for diabetes mellitus using microencapsulated pancreatic β cell line with glucose sensor, Tatsunobu Yoshioka,Naoki Okada,Hajime Miyamoto,Kayoko Sakamoto,Yasuo Tsutsumi,Skinsaku Nakagawa,Tadanori Mayumi,Jun-ichi Miyazaki, Drug Delivery System, Vol. 13, No. 2, p. 95-100, 1998
Optimum bioconjugated TNF-α selectively enhanced its antitumor potency and reduces side-effects, YAMAMOTO YOKO,KANEDA YOSHIHISA,TSUNODA SHIN-ICHI,KAMADA HARUHIKO,KODAIRA HIROSHI,TSUTSUMI YASUO,ITO YUKO,HIRANO TAKASHI,MAYUMI TADANORI, J. Pharm. Sci. Technol. Jpn., Vol. 58, No. 1, p. 37-45, 1998
Antitumor activity of tumor necrosis factor alpha conjugated with divinyl ether and maleic anhydride copolymer on solid tumors in mice, Y Kaneda,Y Yamamoto,H Kamada,S Tsunoda,Y Tsutsumi,T Hirano,T Mayumi, CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, Vol. 58, No. 2, p. 290-295, 1998/01
Amino acids and peptides - XXXII: A bifunctional poly(ethylene glycol) hybrid of fibronectin-related peptides, M Maeda,Y Izuno,K Kawasaki,Y Kaneda,Y Mu,Y Tsutsumi,KW Lem,T Mayumi, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC, Vol. 241, No. 2, p. 595-598, 1997/12
Amino acids and peptides - XXXII: A bifunctional poly(ethylene glycol) hybrid of fibronectin-related peptides, M Maeda,Y Izuno,K Kawasaki,Y Kaneda,Y Mu,Y Tsutsumi,KW Lem,T Mayumi, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC, Vol. 241, No. 2, p. 595-598, 1997/12
Positively charged liposome functions as an efficient immunoadjuvant in inducing immune responses to soluble proteins, Tsuyoshi Nakanishi,Jun Kunisawa,Akira Hayashi,Yasuo Tsutsumi,Kazuyoshi Kubo,Shinkasu Nakagawa,Hiromi Fujiwara,Toshiyuki Hamaoka,Tadanori Mayumi, Biochemical and Biophysical Research Communications, Academic Press Inc., Vol. 240, No. 3, p. 793-797, 1997/11/26
Amino acids and peptides .30. Preparation of Arg-Gly-Asp (RGD) hybrids with poly(ethylene glycol) analogs and their antimetastatic effect, M Maeda,Y Izuno,K Kawasaki,Y Kaneda,Y Mu,Y Tsutsumi,S Nakagawa,T Mayumi, CHEMICAL & PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOC JAPAN, Vol. 45, No. 11, p. 1788-1792, 1997/11
ワクチンベクターとしてのLipofectinによる抗原提示促進作用とin vivoにおけるアジュバント効果, 中西剛,國澤純,林哲,山内由紀枝,堤康央,濱岡利之,藤原大美,真弓忠範, 薬物動態 = Xenobiotic metabolism and disposition, Vol. 12, p. 283-283, 1997/10/09
Bioconjugation of tumor necrosis factor-alpha with the copolymer of divinyl ether and maleic anhydride increasing its antitumor potency, Y Kaneda,Y Yamamoto,S Tsunoda,H Kamada,Y Tsutsumi,T Hirano,T Mayumi, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC ELSEVIER SCIENCE, Vol. 239, No. 1, p. 160-165, 1997/10
Bioconjugation of tumor necrosis factor-alpha with the copolymer of divinyl ether and maleic anhydride increasing its antitumor potency, Y Kaneda,Y Yamamoto,S Tsunoda,H Kamada,Y Tsutsumi,T Hirano,T Mayumi, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC ELSEVIER SCIENCE, Vol. 239, No. 1, p. 160-165, 1997/10
Antimetastatic effect of synthetic Glu-Ile-Leu-Asp-Val peptide derivatives containing D-amine acids, Y Kaneda,Y Yamamoto,N Okada,Y Tsutsumi,S Nakagawa,M Kakiuch,M Maeda,K Kawasaki,T Mayumi, ANTI-CANCER DRUGS, RAPID SCIENCE PUBLISHERS, Vol. 8, No. 7, p. 702-707, 1997/08
Antimetastatic effect of synthetic Glu-Ile-Leu-Asp-Val peptide derivatives containing D-amine acids, Y Kaneda,Y Yamamoto,N Okada,Y Tsutsumi,S Nakagawa,M Kakiuch,M Maeda,K Kawasaki,T Mayumi, ANTI-CANCER DRUGS, RAPID SCIENCE PUBLISHERS, Vol. 8, No. 7, p. 702-707, 1997/08
Antibody-based therapy targeting tumor vascular endothelial cells suppresses solid tumor growth in rats, Ohizumi, I,S Tsunoda,K Taniguchi,H Saito,K Esaki,H Makimoto,Y Wakai,Y Tsutsumi,S Nakagawa,N Utoguchi,S Kaiho,Y Ohsugi,T Mayumi, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS, Vol. 236, No. 2, p. 493-496, 1997/07
Antibody-based therapy targeting tumor vascular endothelial cells suppresses solid tumor growth in rats, Ohizumi, I,S Tsunoda,K Taniguchi,H Saito,K Esaki,H Makimoto,Y Wakai,Y Tsutsumi,S Nakagawa,N Utoguchi,S Kaiho,Y Ohsugi,T Mayumi, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS, Vol. 236, No. 2, p. 493-496, 1997/07
Molecular design of intellectually bioactivated protein by modified functional polymer. Invention of DIVEMA hybrid TNF-.ALPHA. and its evaluation., 山本陽子,金田善久,鎌田春彦,小平浩史,堤康央,久保一義,中川晋作,堀沢義史,平野隆, 日本薬学会年会要旨集, Vol. 117th, No. 4, 1997/03
Development of a pH responsiveness decorated giant molecule and application to hybridized DDS., 鎌田春彦,金田喜久,山本陽子,小平浩史,堤康央,久保一義,中川晋作,青木俊二,真弓忠範, 日本薬学会年会要旨集, Vol. 117th, No. 4, 1997/03
Antitumor vaccine effect reinforcement of liposome adjuvant by cationization., 国沢純,中西剛,林哲,久保一義,中川晋作,堤康央,水口裕之,藤原大美,浜岡利之, 日本薬学会年会要旨集, Vol. 117th, No. 4, 1997/03
Hybridization of fibronectin-related peptides by amino acid type PEG derivatives., 伊豆野康広,前田光子,川崎紘一,金田喜久,牟宇,堤康央,中川晋作,真弓忠範, 日本薬学会年会要旨集, Vol. 117th, No. 2, 1997/03
Molecular design of water-soluble polymer hybridized medicine. (2 ) In vivo specific behaviors of various water-soluble polymers., 金田喜久,鎌田春彦,山本陽子,小平浩史,堤康央,久保一義,中川晋作,真弓忠範, 日本薬学会年会要旨集, Vol. 117th, No. 4, 1997/03
Induction reinforcement of antitumor immunity using cationic liposome as tumor vaccine vector., 中西剛,国沢純,林哲,久保一義,中川晋作,堤康央,水口裕之,藤原大美,浜岡利之, 日本薬学会年会要旨集, Vol. 117th, No. 4, 1997/03
Particle design of optimal membrane fusion liposome as a gene transfer vector., 鈴木亮,中川哲彦,堤康央,久保一義,中川晋作,真弓忠範,水口裕之,中西真人, 日本薬学会年会要旨集, Vol. 117th, No. 4, 1997/03
Local administration of estrogen inhibits transplant arteriosclerosis in rat aorta accelerated by topical exposure to IGF-I, N Motomura,H Lou,M Hong,Y Tsutsumi,T Mayumi,ML Foegh, TRANSPLANTATION PROCEEDINGS, ELSEVIER SCIENCE INC, Vol. 29, No. 1-2, p. 1118-1120, 1997/02
Medical application of microencapsulating hybridoma cells in agarose microbeads 'cytomedicine': Therapeutic effect on IgG1 plasmacytosis and mesangio-proliferative glomerulonephritis in the interleukin 6 transgenic mouse, N Okada,H Miyamoto,Y Kaneda,Y Yamamoto,A Katsume,H Saito,K Yorozu,O Ueda,Y Tsutsumi,S Nakagawa,Y Ohsugi,T Mayumi, JOURNAL OF CONTROLLED RELEASE, ELSEVIER SCIENCE BV, Vol. 44, No. 2-3, p. 195-200, 1997/02
Local administration of estrogen inhibits transplant arteriosclerosis in rat aorta accelerated by topical exposure to IGF-I, N Motomura,H Lou,M Hong,Y Tsutsumi,T Mayumi,ML Foegh, TRANSPLANTATION PROCEEDINGS, ELSEVIER SCIENCE INC, Vol. 29, No. 1-2, p. 1118-1120, 1997/02
Medical application of microencapsulating hybridoma cells in agarose microbeads 'cytomedicine': Therapeutic effect on IgG1 plasmacytosis and mesangio-proliferative glomerulonephritis in the interleukin 6 transgenic mouse, N Okada,H Miyamoto,Y Kaneda,Y Yamamoto,A Katsume,H Saito,K Yorozu,O Ueda,Y Tsutsumi,S Nakagawa,Y Ohsugi,T Mayumi, JOURNAL OF CONTROLLED RELEASE, ELSEVIER SCIENCE BV, Vol. 44, No. 2-3, p. 195-200, 1997/02
Fundamental study on molecular design of bioconjugated drugs with water-soluble polymeric modifiers: Influence of electric charge on pharmacokinetics of water-soluble polymers, Hiroshi Kodaira,Yoshihisa Kaneda,Yoko Yamamoto,Takashi Namba,Yasuo Tsutsumi,Tadanori Mayumi,Takashi Hirano, Drug Delivery System, Vol. 12, No. 6, p. 431-437, 1997
Lecithinization of IL-6 enhances its thrombopoietic activity in mice, R Igarashi,Y Tsutsumi,H Fujii,S Tsunoda,A Ochiai,M Takenaga,Y Morizawa,T Mayumi,Y Mizushima, JOURNAL OF PHARMACY AND PHARMACOLOGY, ROYAL PHARMACEUTICAL SOC GREAT BRITAIN, Vol. 49, No. 1, p. 113-118, 1997/01
PEGylation of interleukin-6 effectively increases its thrombopoietic potency, Y Tsutsumi,SI Tsunoda,H Kamada,T Kihira,Y Kaneda,Y Ohsugi,T Mayumi, THROMBOSIS AND HAEMOSTASIS, F K SCHATTAUER VERLAG GMBH, Vol. 77, No. 1, p. 168-173, 1997/01
次世代の薬物治療を担う分子レベルでのDrug Delivery System., 堤康央,真弓忠範, 生産と技術, 生産技術振興協会, Vol. 49, No. 1, p. 65-68, 1997
Preparation of a poly(ethylene glycol)hybrid containint two active fragments of laminin, 1997
Positively charged liposome functions as an efficient immunoadjuvantin inducing immune responses to soluble proteins, Biochem. Biophys. Res. Commun., Vol. 240, No. 3, p. 793-797, 1997
Fundamental study on molecular design of bioconjugated drugs with water-soluble polymeric modifiers: Influence of electric charge on pharmacokinetics of water-soluble polymers, Hiroshi Kodaira,Yoshihisa Kaneda,Yoko Yamamoto,Takashi Namba,Yasuo Tsutsumi,Tadanori Mayumi,Takashi Hirano, Drug Delivery System, Vol. 12, No. 6, p. 431-437, 1997
Bioconjugation as drug delivery system, Vol. 49(1), p. 65-68, 1997
Lecithinization of IL-6 enhances its thrombopoietic activity in mice, R Igarashi,Y Tsutsumi,H Fujii,S Tsunoda,A Ochiai,M Takenaga,Y Morizawa,T Mayumi,Y Mizushima, JOURNAL OF PHARMACY AND PHARMACOLOGY, ROYAL PHARMACEUTICAL SOC GREAT BRITAIN, Vol. 49, No. 1, p. 113-118, 1997/01
PEGylation of interleukin-6 effectively increases its thrombopoietic potency, Y Tsutsumi,SI Tsunoda,H Kamada,T Kihira,Y Kaneda,Y Ohsugi,T Mayumi, THROMBOSIS AND HAEMOSTASIS, F K SCHATTAUER VERLAG GMBH, Vol. 77, No. 1, p. 168-173, 1997/01
Amino acids and peptides .29. Synthesis and antimetastatic effects of peptides and peptide-poly(ethylene glycol) hybrids related to the core sequence of the type III connecting segment domain of fibronectin, K Kawasaki,M Maeda,S Inoue,Y Yamashiro,Y Kaneda,Y Mu,Y Tsutsumi,S Nakagawa,T Mayumi, BIOLOGICAL & PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOC JAPAN, Vol. 19, No. 12, p. 1574-1579, 1996/12
Amino acids and peptides .29. Synthesis and antimetastatic effects of peptides and peptide-poly(ethylene glycol) hybrids related to the core sequence of the type III connecting segment domain of fibronectin, K Kawasaki,M Maeda,S Inoue,Y Yamashiro,Y Kaneda,Y Mu,Y Tsutsumi,S Nakagawa,T Mayumi, BIOLOGICAL & PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOC JAPAN, Vol. 19, No. 12, p. 1574-1579, 1996/12
In vivo anti-tumor efficacy of polyethylene glycol-modified tumor necrosis factor-alpha against tumor necrosis factor-resistant tumors, Y Tsutsumi,S Tsunoda,Y Kaneda,H Kamada,T Kihira,S Nakagawa,Y Yamamoto,Y Horisawa,T Mayumi, JAPANESE JOURNAL OF CANCER RESEARCH, JAPANESE CANCER ASSOCIATION, Vol. 87, No. 10, p. 1078-1085, 1996/10
Molecular design of hybrid tumour necrosis factor-alpha .2. The molecular size of polyethylene glycol-modified tumour necrosis factor-alpha affects its antitumour potency, Y Tsutsumi,S Tsunoda,H Kamada,T Kihira,S Nakagawa,Y Kaneda,T Kanamori,T Mayumi, BRITISH JOURNAL OF CANCER, STOCKTON PRESS, Vol. 74, No. 7, p. 1090-1095, 1996/10
In vivo anti-tumor efficacy of polyethylene glycol-modified tumor necrosis factor-alpha against tumor necrosis factor-resistant tumors, Y Tsutsumi,S Tsunoda,Y Kaneda,H Kamada,T Kihira,S Nakagawa,Y Yamamoto,Y Horisawa,T Mayumi, JAPANESE JOURNAL OF CANCER RESEARCH, JAPANESE CANCER ASSOCIATION, Vol. 87, No. 10, p. 1078-1085, 1996/10
Molecular design of hybrid tumour necrosis factor-alpha .2. The molecular size of polyethylene glycol-modified tumour necrosis factor-alpha affects its antitumour potency, Y Tsutsumi,S Tsunoda,H Kamada,T Kihira,S Nakagawa,Y Kaneda,T Kanamori,T Mayumi, BRITISH JOURNAL OF CANCER, STOCKTON PRESS, Vol. 74, No. 7, p. 1090-1095, 1996/10
Molecular design of hybrid tumor necrosis factor-alpha III: Polyethylene glycol-modified tumor necrosis factor-alpha has markedly enhanced antitumor potency due to longer plasma half-life and higher tumor accumulation, Y Tsutsumi,T Kihira,S Tsunoda,H Kamada,S Nakagawa,Y Kaneda,T Kanamori,T Mayumi, JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, WILLIAMS & WILKINS, Vol. 278, No. 3, p. 1006-1011, 1996/09
Molecular design of hybrid tumor necrosis factor-alpha III: Polyethylene glycol-modified tumor necrosis factor-alpha has markedly enhanced antitumor potency due to longer plasma half-life and higher tumor accumulation, Y Tsutsumi,T Kihira,S Tsunoda,H Kamada,S Nakagawa,Y Kaneda,T Kanamori,T Mayumi, JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, WILLIAMS & WILKINS, Vol. 278, No. 3, p. 1006-1011, 1996/09
ハイブリッド化IL-6の創製と血小板増加作用増強効果, 角田慎一,金田喜久,鎌田春彦,山本陽子,堤康央,大杉義征,真弓忠範, 日本分子生物学会年会プログラム・講演要旨集, Vol. 19, p. 380-380, 1996/08/01
水溶性高分子ハイブッリドTNFの作製とその抗腫瘍効果, 鎌田春彦,金田喜久,山本陽子,角田慎一,紀平哲也,金森利至,堤康央,真弓忠範, 日本分子生物学会年会プログラム・講演要旨集, Vol. 19, p. 380-380, 1996/08/01
DIVEMAによるハイブリッド化TNF-aの創製とその評価, 山本陽子,金田喜久,角田慎一,鎌田春彦,堤康央,金森利至,平野隆,真弓忠範, 日本分子生物学会年会プログラム・講演要旨集, Vol. 19, p. 380-380, 1996/08/01
Selective enhancement by tumor necrosis factor-alpha of vascular permeability of new blood vessels induced with agarose hydrogel-entrapped Meth-A fibrosarcoma cells, N Okada,Y Kaneda,H Miyamoto,Y Yamamoto,H Mizuguchi,Y Tsutsumi,S Nakagawa,T Mayumi, JAPANESE JOURNAL OF CANCER RESEARCH, JAPANESE CANCER ASSOCIATION, Vol. 87, No. 8, p. 831-836, 1996/08
Selective enhancement by tumor necrosis factor-alpha of vascular permeability of new blood vessels induced with agarose hydrogel-entrapped Meth-A fibrosarcoma cells, N Okada,Y Kaneda,H Miyamoto,Y Yamamoto,H Mizuguchi,Y Tsutsumi,S Nakagawa,T Mayumi, JAPANESE JOURNAL OF CANCER RESEARCH, JAPANESE CANCER ASSOCIATION, Vol. 87, No. 8, p. 831-836, 1996/08
Manufacture of specific antibody for vascular endothelial cell of tumor tissue and its evaluation., 槙本博雄,若井由紀子,角田慎一,堤康央,久保一義,中川晋作,真弓忠範,宇都口直樹,大杉義征, 日本薬学会年会要旨集, Vol. 116th, No. Pt 4, p. 75-75, 1996/03
Development of targetting therapy for vascular endothelial cell of tumor tissue using monoclonal antibody., 若井由紀子,槙本博雄,角田慎一,堤康央,久保一義,中川晋作,真弓忠範,宇都口直樹,大杉義征, 日本薬学会年会要旨集, Vol. 116th, No. Pt 4, p. 75-75, 1996/03
Molecular design of water-soluble high-molecular hybridized drug. Effect of balance in hydrophilicity and hydrophobicity on in-vivo behavior of decorated high polymer., 金田喜久,角田慎一,鎌田春彦,山本陽子,槙本博雄,堤康央,久保一義,中川晋作,真弓忠範, 日本薬学会年会要旨集, Vol. 116th, No. Pt 4, p. 74-74, 1996/03
Molecular design of polyfunctional hybridized biologically active substance. PVP hybridization of hemopoietic cytokine., 角田慎一,金田喜久,鎌田春彦,山本陽子,槙本博雄,堤康央,久保一義,中川晋作,大杉義征, 日本薬学会年会要旨集, Vol. 116th, No. Pt 4, p. 75-75, 1996/03
Basic examination on development of cell drug using cell-filled alginic acid- polylysine-alginic acid microcapsule., 宮本創,岡田直貴,吉岡竜伸,堤康央,中川晋作,真弓忠範,勝目朝夫,万啓悟,大杉義征, 日本薬学会年会要旨集, Vol. 116th, No. Pt 4, p. 70-70, 1996/03
Synthesis of laminin-related peptide and metastasis control action., 伊豆野康広,柿内雅,前田光子,川崎紘一,金田喜久,堤康央,中川晋作,真弓忠範, 日本薬学会年会要旨集, Vol. 116th, No. Pt 2, 1996/03
Preparation of RGD-polyoxyalkyleneamine hybrid and its inhibitory effect on experimental metastasis, Izuno Y,Kurosaka T,Maeda M,Kawasaki K,Kaneda Y,Mu Y,Tsutsumi Y,Nakagawa S,Mayumi T, Peptide Chem., No. 1996, p. 265-268, 1996
Optimization of drug therapy based on molecular design of hybrid bioactive proteins with water-soluble polymers, KANEDA Y., Trans. Mater. Res. Soc. Jpn., (MRS-J), Vol. 20, No. 20, p. 1-4, 1996
Evaluation of angiogenic inhibitors with an in vivo quantitative angiogenesis method using agarose microencapsulation and mouse hemoglobin enzyme-linked immunosolvent assay, Okada N,Fushimi M,Nagata Y,Fukunaga T,Tsutsumi Y,Nakagawa S,Mayumi T, Jpn. J. Cancer Res., No. 87, p. 963-971, 1996
Effect of tumour cell-conditioned medium on endothelial macromolecular permeability and its correlation with collagen, N Utoguchi,H Mizuguchi,A Dantakean,H Makimoto,Y Wakai,Y Tsutsumi,S Nakagawa,T Mayumi, BRITISH JOURNAL OF CANCER, STOCKTON PRESS, Vol. 73, No. 1, p. 24-28, 1996/01
サイトカインのバイオコンジュゲーションと粘膜免疫療法への可能性, 堤康央,真弓忠範, 医学のあゆみ別冊/生体防御の最前線, p. 196-201, 1996
Molecular design of hybrid cytokines with water soluble polymers, Y Tsutsumi,S Nakagawa,T Mayumi, 23RD INTERNATIONAL SYMPOSIUM ON CONTROLLED RELEASE OF BIOACTIVE MATERIALS, 1996 PROCEEDINGS, CONTROLLED RELEASE SOCIETY INC, p. 871-872, 1996
Lecithinization of IL-6 enhances its thrombopoietic activity in mice, M Takenaga,R Igarashi,Y Tsutsumi,H Fujii,S Tsunoda,Y Morizawa,T Mayumi,Y Mizushima, 23RD INTERNATIONAL SYMPOSIUM ON CONTROLLED RELEASE OF BIOACTIVE MATERIALS, 1996 PROCEEDINGS, CONTROLLED RELEASE SOCIETY INC, p. 623-624, 1996
Development of novel delivery system for bioactive molecules using immobilized cells., 1996
Bioconjugation of cytokines and its application for mucosal immunotherapy, Vol. 別冊(生体防御の最前線), p. 196-201, 1996
Preparation of RGD-Polyoxyalkyleneamine Hybrid and Its Inhibitory Effect on Experimental Metastasis., Peptide Chem., Vol. 1996, p. 265-268, 1996
Optimization of drug therapy based on molecular design of hybrid bioactive proteins with water-soluble polymers., Transaction of the Materials Research Society of Japan(MRS-J), Vol. 20, p. 1-4, 1996
Evaluation of angiogenic inhibitors with an in vivo quantitative angiogenesis method using agarose microencapsulation and mouse hemoglobin enzyme-linked immunosorbent assay, Naoki Okada,Mariko Fushimi,Yuriko Nagata,Tomoko Fukunaga,Yasuo Tsutsumi,Shinsaku Nakagawa,Tadanori Mayumi, Japanese Journal of Cancer Research, Japanese Cancer Association, Vol. 87, No. 9, p. 952-957, 1996
Effect of tumour cell-conditioned medium on endothelial macromolecular permeability and its correlation with collagen, N Utoguchi,H Mizuguchi,A Dantakean,H Makimoto,Y Wakai,Y Tsutsumi,S Nakagawa,T Mayumi, BRITISH JOURNAL OF CANCER, STOCKTON PRESS, Vol. 73, No. 1, p. 24-28, 1996/01
Amino acids and peptides .26. Laminin-related peptide poly(ethylene glycol) hybrids and their inhibitory effect on experimental metastasis, K Kawasaki,M Namikawa,T Mizuta,S Inoue,M Maeda,M Kakiuchi,Y Izuno,S Yamamoto,Y Tsutsumi,S Nakagawa,T Mayumi, BIOLOGICAL & PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOC JAPAN, Vol. 18, No. 12, p. 1714-1717, 1995/12
Amino acids and peptides .25. Preparation of fibronectin-related peptide poly(ethylene glycol) hybrids and their inhibitory effect on experimental metastasis, K Kawasaki,M Namikawa,Y Yamashiro,Y Iwai,T Hama,Y Tsutsumi,S Yamamoto,S Nakagawa,T Mayumi, CHEMICAL & PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOC JAPAN, Vol. 43, No. 12, p. 2133-2138, 1995/12
A quantitative in vivo method of analyzing human tumor-induced angiogenesis in mice using agarose microencapsulation and hemoglobin enzyme-linked immunosorbent assay, N Okada,M Fushimi,Y Nagata,T Fukunaga,Y Tsutsumi,S Nakagawa,T Mayumi, JAPANESE JOURNAL OF CANCER RESEARCH, JAPANESE CANCER ASSOCIATION, Vol. 86, No. 12, p. 1182-1188, 1995/12
Amino acids and peptides .26. Laminin-related peptide poly(ethylene glycol) hybrids and their inhibitory effect on experimental metastasis, K Kawasaki,M Namikawa,T Mizuta,S Inoue,M Maeda,M Kakiuchi,Y Izuno,S Yamamoto,Y Tsutsumi,S Nakagawa,T Mayumi, BIOLOGICAL & PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOC JAPAN, Vol. 18, No. 12, p. 1714-1717, 1995/12
Amino acids and peptides .25. Preparation of fibronectin-related peptide poly(ethylene glycol) hybrids and their inhibitory effect on experimental metastasis, K Kawasaki,M Namikawa,Y Yamashiro,Y Iwai,T Hama,Y Tsutsumi,S Yamamoto,S Nakagawa,T Mayumi, CHEMICAL & PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOC JAPAN, Vol. 43, No. 12, p. 2133-2138, 1995/12
A quantitative in vivo method of analyzing human tumor-induced angiogenesis in mice using agarose microencapsulation and hemoglobin enzyme-linked immunosorbent assay, N Okada,M Fushimi,Y Nagata,T Fukunaga,Y Tsutsumi,S Nakagawa,T Mayumi, JAPANESE JOURNAL OF CANCER RESEARCH, JAPANESE CANCER ASSOCIATION, Vol. 86, No. 12, p. 1182-1188, 1995/12
Basic examination on substance transmission mechanisms of tumor tissue intravascular endothelial cells., 槙本博雄,若井由紀子,宇都口直樹,堤康央,中川晋作,真弓忠範, 薬物動態, Vol. 10, No. Suppl, 1995/10
PEG 修飾インターロイキン -6, 堤康央,中川晋作,真弓忠範, 生化学, 日本生化学会, Vol. 67, No. 6, p. 465-469, 1995/06/25
Synthetic: Cell-adhesive laminin peptide YIGSR conjugated with polyethylene glycol has improved antimetastatic activity due to a longer half-life in blood, Y Kaneda,S Yamamoto,T Kihira,Y Tsutsumi,S Nakagawa,M Miyake,K Kawasaki,T Mayumi, INVASION & METASTASIS, KARGER, Vol. 15, No. 3-4, p. 156-162, 1995/05
MOLECULAR DESIGN OF HYBRID TUMOR-NECROSIS-FACTOR-ALPHA WITH POLYETHYLENE-GLYCOL INCREASES ITS ANTITUMOR POTENCY, Y TSUTSUMI,T KIHIRA,S TSUNODA,T KANAMORI,S NAKAGAWA,T MAYUMI, BRITISH JOURNAL OF CANCER, STOCKTON PRESS, Vol. 71, No. 5, p. 963-968, 1995/05
Synthetic: Cell-adhesive laminin peptide YIGSR conjugated with polyethylene glycol has improved antimetastatic activity due to a longer half-life in blood, Y Kaneda,S Yamamoto,T Kihira,Y Tsutsumi,S Nakagawa,M Miyake,K Kawasaki,T Mayumi, INVASION & METASTASIS, KARGER, Vol. 15, No. 3-4, p. 156-162, 1995/05
MOLECULAR DESIGN OF HYBRID TUMOR-NECROSIS-FACTOR-ALPHA WITH POLYETHYLENE-GLYCOL INCREASES ITS ANTITUMOR POTENCY, Y TSUTSUMI,T KIHIRA,S TSUNODA,T KANAMORI,S NAKAGAWA,T MAYUMI, BRITISH JOURNAL OF CANCER, STOCKTON PRESS, Vol. 71, No. 5, p. 963-968, 1995/05
Bioconjugate of biological-active proteins with water-soluble polymers for the clinical application, TSUTSUMI Yasuo,NAKAGAWA Shinsaku,MAYUMI Tadanori, Drug Delivery System, THE JAPAN SOCIETY OF DRUG DELIVERY SYSTEM, Vol. 10, No. 2, p. 75-84, 1995/03/10
多機能性ハイブリッド生理活性蛋白質の分子設計: PVPハイブリッドTNF‐αの創製とその評価, 紀平哲也,角田慎一,鎌田春彦,堤康央,中川晋作,真弓忠範,金森利至,栗本雅司, 日本薬学会年会要旨集, Vol. 115th, No. Pt 4, 1995/03
POLYETHYLENE-GLYCOL MODIFICATION OF INTERLEUKIN-6 ENHANCES ITS THROMBOPOIETIC ACTIVITY, Y TSUTSUMI,T KIHIRA,S TSUNODA,N OKADA,Y KANEDA,Y OHSUGI,M MIYAKE,S NAKAGAWA,T MAYUMI, JOURNAL OF CONTROLLED RELEASE, ELSEVIER SCIENCE BV, Vol. 33, No. 3, p. 447-451, 1995/03
POLYETHYLENE-GLYCOL MODIFICATION OF INTERLEUKIN-6 ENHANCES ITS THROMBOPOIETIC ACTIVITY, Y TSUTSUMI,T KIHIRA,S TSUNODA,N OKADA,Y KANEDA,Y OHSUGI,M MIYAKE,S NAKAGAWA,T MAYUMI, JOURNAL OF CONTROLLED RELEASE, ELSEVIER SCIENCE BV, Vol. 33, No. 3, p. 447-451, 1995/03
TUMOR-CONDITIONED MEDIUM INCREASES MACROMOLECULAR PERMEABILITY OF ENDOTHELIAL-CELL MONOLAYER, N UTOGUCHI,H MIZUGUCHI,K SAEKI,K IKEDA,Y TSUTSUMI,S NAKAGAWA,T MAYUMI, CANCER LETTERS, ELSEVIER SCI PUBL IRELAND LTD, Vol. 89, No. 1, p. 7-14, 1995/02
ISOLATION AND PROPERTIES OF TUMOR-DERIVED ENDOTHELIAL-CELLS FROM RAT KMT-17 FIBROSARCOMA, N UTOGUCHI,A DANTAKEAN,H MAKIMOTO,Y WAKAI,Y TSUTSUMI,S NAKAGAWA,T MAYUMI, JAPANESE JOURNAL OF CANCER RESEARCH, JAPANESE CANCER ASSOCIATION, Vol. 86, No. 2, p. 193-201, 1995/02
サイトカインの臨床応用サイトカインのDrug Delivery System, 堤康央,中川晋作,真弓忠範, 臨床免疫, (有)科学評論社, Vol. 27, No. Suppl.16, p. 610-616, 1995/02
TUMOR-CONDITIONED MEDIUM INCREASES MACROMOLECULAR PERMEABILITY OF ENDOTHELIAL-CELL MONOLAYER, N UTOGUCHI,H MIZUGUCHI,K SAEKI,K IKEDA,Y TSUTSUMI,S NAKAGAWA,T MAYUMI, CANCER LETTERS, ELSEVIER SCI PUBL IRELAND LTD, Vol. 89, No. 1, p. 7-14, 1995/02
ISOLATION AND PROPERTIES OF TUMOR-DERIVED ENDOTHELIAL-CELLS FROM RAT KMT-17 FIBROSARCOMA, N UTOGUCHI,A DANTAKEAN,H MAKIMOTO,Y WAKAI,Y TSUTSUMI,S NAKAGAWA,T MAYUMI, JAPANESE JOURNAL OF CANCER RESEARCH, JAPANESE CANCER ASSOCIATION, Vol. 86, No. 2, p. 193-201, 1995/02
PREPARATION OF RGD-POLYOXYALKYLENEAMINE HYBRID AND ITS INHIBITORY EFFECT ON EXPERIMENTAL METASTASIS, M MAEDA,M KAKIUCHI,K KAWASAKI,Y KANEDA,S NAKAGAWA,T MAYUMI, PEPTIDE CHEMISTRY 1994, PROTEIN RESEARCH FOUNDATION, No. 1994, p. 381-384, 1995
Characterization of PEG-IL-6 and its thrombopoietic activity in vivo, Shin-ichi Tsunoda,Tetsunari Kihira,Haruhiko Kamada,Naoki Okada,Yoshiyuki Osugi,Yasuo Tsutsumi,Shinsaku Nakagawa,Tadanori Mayumi, Drug Delivery System, Vol. 10, No. 3, p. 175-180, 1995
ハイブリッド生理活性ペプチド･蛋白質製剤の分子設計, 堤康央,中川晋作,真弓忠範, Molecular Medicine別冊/DDSの進歩, p. 82-94, 1995
Molecular Design of Hybrid bioactive peptides and proteins., Molecular Medicine, p. 82-94, 1995
PEGylation of Interleukin-6, Seikagaku, Vol. 67, p. 465-469, 1995
Preparation of RGD-Polyoxyalkyleneamine Hybrid and Its Inhibitory Effect on Experimental Metastasis., Peptide Chem. (Peptide Chemistry), Vol. 1994, p. 381-384, 1995
Drug Delivary System of cytokine, Clin. Immunol. (Clinical Immunology), Vol. 27, p. 610-616, 1995
Bioconjugate of biological-active proteins with water-soluble polymers for the clinical application, Yasuo Tsutsumi,Shinsaku Nakagawa,Tadanori Mayumi, Drug Delivery System, Vol. 10, No. 2, p. 75-84, 1995
Characterization of PEG-IL-6 and its thrombopoietic activity in vivo, Shin-ichi Tsunoda,Tetsunari Kihira,Haruhiko Kamada,Naoki Okada,Yoshiyuki Osugi,Yasuo Tsutsumi,Shinsaku Nakagawa,Tadanori Mayumi, Drug Delivery System, Vol. 10, No. 3, p. 175-180, 1995
INTRAVENOUS ADMINISTRATION OF POLYETHYLENE GLYCOL-MODIFIED TUMOR-NECROSIS-FACTOR-ALPHA COMPLETELY REGRESSED SOLID TUMOR IN METH-A MURINE SARCOMA MODEL, Y TSUTSUMI,T KIHIRA,S TSUNODA,K KUBO,M MIYAKE,T KANAMORI,S NAKAGAWA,T MAYUMI, JAPANESE JOURNAL OF CANCER RESEARCH, JAPANESE CANCER ASSOCIATION, Vol. 85, No. 12, p. 1185-1188, 1994/12
INTRAVENOUS ADMINISTRATION OF POLYETHYLENE GLYCOL-MODIFIED TUMOR-NECROSIS-FACTOR-ALPHA COMPLETELY REGRESSED SOLID TUMOR IN METH-A MURINE SARCOMA MODEL, Y TSUTSUMI,T KIHIRA,S TSUNODA,K KUBO,M MIYAKE,T KANAMORI,S NAKAGAWA,T MAYUMI, JAPANESE JOURNAL OF CANCER RESEARCH, JAPANESE CANCER ASSOCIATION, Vol. 85, No. 12, p. 1185-1188, 1994/12
水溶性高分子ハイブリッドTNF‐αの分子設計最適のハイブリッド化条件の追究, 紀平哲也,堤康央,角田慎一,鎌田春彦,久保一義,中川晋作,真弓忠範, 薬物動態, Vol. 9, No. Suppl, 1994/10
水溶性高分子ハイブリッドタンパク質の分子設計, 堤康央,中川晋作,川崎紘一, カレントテラピー, (株)ライフメディコム, Vol. 12, No. 7, p. 1394-1405, 1994/06
CHEMICAL MODIFICATION OF NATURAL HUMAN TUMOR-NECROSIS-FACTOR-ALPHA WITH POLYETHYLENE-GLYCOL INCREASES ITS ANTITUMOR POTENCY, Y TSUTSUMI,T KIHIRA,S YAMAMOTO,K KUBO,S NAKAGAWA,M MIYAKE,Y HORISAWA,T KANAMORI,H IKEGAMI,T MAYUMI, JAPANESE JOURNAL OF CANCER RESEARCH, JAPANESE CANCER ASSOCIATION, Vol. 85, No. 1, p. 9-12, 1994/01
水溶性ハイブリッドタンパク質の分子設計, 堤康央,中川晋作,川崎紘一,真弓忠範, カレントテラピー, Vol. 12, No. 7, p. 176-187, 1994
Molecular design of hybride protein with water-soluble polymers, Current Therapy, Vol. 12, p. 176-187, 1994
CHEMICAL MODIFICATION OF NATURAL HUMAN TUMOR-NECROSIS-FACTOR-ALPHA WITH POLYETHYLENE-GLYCOL INCREASES ITS ANTITUMOR POTENCY, Y TSUTSUMI,T KIHIRA,S YAMAMOTO,K KUBO,S NAKAGAWA,M MIYAKE,Y HORISAWA,T KANAMORI,H IKEGAMI,T MAYUMI, JAPANESE JOURNAL OF CANCER RESEARCH, JAPANESE CANCER ASSOCIATION, Vol. 85, No. 1, p. 9-12, 1994/01
ハイブリッドTNF‐αの創製:PEG修飾によるIn Vivo抗腫よう活性の増強, 堤康央,紀平哲也,真弓忠範,堀沢義史,池上伯郎,中川晋作,三宅正治, 日本薬学会年会要旨集, Vol. 113th, No. Pt 4, 1993/03
Progress in Drug Delivery System Ⅱ･PEG ハイブリッド化によるTNF-alpha の抗腫瘍活性の増強, 堤康央,紀平哲也,久保一義,中川晋作,真弓忠範, Biomedical Research Foundation, p. 139-145, 1993
ヒト血管内皮細胞のIN VITRO血管新生能に及ぼす細胞外マトリックスの影響, 山本晋,伏見真理子,岡田直貴,堤康央,久保一義,真弓忠範,並川真知子,中川晋作,柴原健, 日本薬学会年会要旨集, Vol. 112th, No. Pt 4, 1992/03
PEGylation of adenovirus vector enhances gene expression in tumor via systemic administration., The 10th Annual Meeting 2004 The Japan Gene Therapy,Tokyo.
Mukai Y., Yoshioka Y., Tsutsumi Y.(Corresponding Author) : Phage display and PEGylation of therapeutic proteins.,, Combinatorial Chemistry & High Throughput Screening, Vol. in press.
Y. Mukai, Y. Tsutsumi, Y.Yoshioka, T. Mayumi Bioconjugation of peptides and proteins with polymeric modifiers for improvement of their therapeutic efficacy., Current topics in peptides and protein research., Vol. in press.
H. Shibata, S. Nakagawa, Y. Tsutsumi. Optimization of protein therapies by polymer-conjugation as an effective DDS., Molecules, Vol. in press.
Shibata H., Mayumi T., Tsutsumi Y. : Development of novel DDS technologies for pharmacoproteomic-based drug discovery and development.,, Biol. Pharm. Bull., Vol. in press.
T. Sugita, T. Yoshikawa, J.Q. Gao, M. Shimokawa, A. Oda, T. Niwa, M. Akashi, Y. Tsutsumi, T. Mayumi, S. Nakagawa. Fusogenic liposome can be used as an effective vaccine carrier for peptide vaccination to induce CTL response., Biol Pharm Bull., Vol. in press.
T. Yoshikawa, S. Imazu, J.Q. Gao, K. Hayashi, Y. Tsuda, M. Shimokawa, T. Sugita, T. Niwa, A. Oda, M. Akashi, Y. Tsutsumi, T. Mayumi, S. Nakagawa. Augmentation of antigen specific immune responses using DNA-fusogenic liposome vaccine., Biochem. Biophys. Res. Commun., Vol. in press
Y. Eto, J.Q. Gao, S. Kurachi, F. Sekiguchi, K. Katayama, T. Sugita, H. Mizuguchi, T. Hayakawa, Y. Tsutsumi, T. Mayumi, S. Nakagawa. PEGylated adenovirus vectors containing RGD peptides on the tip of PEG show high transduction efficiency and antibody ev・・・, J. Gene Med., Vol. in press
H. Shibata, Y. Yoshioka, S. Ikemizu, K. Kobayashi, Y. Yamamoto, Y. Mukai, T. Okamoto, M. Taniai, M. Kawamura, Y. Abe, S. Nakagawa, S. Nagata, Y. Yamagata, T. Mayumi, Y. Tsutsumi Functionalization of TNF-alpha using phage display technique and PEGylati・・・, Clin. Cancer Res., Vol. in press
Preparation of a poly(ethylene glycol) hybrid containing two active fragment of laminin., Peptide Chem.

Publications

次世代医薬とバイオ医療, 堤康央, 東京化学同人, ISBN:9784807920181, 2022/03
医学のあゆみ構造生命科学による創薬への挑戦, 芳賀優弥,東阪和馬,堤康央, 医歯薬出版株式会社, 2021/08
生産と技術薬学における毒性学, 一般社団法人生産技術振興協会, 2020
基礎と臨床の両側面からみた胎盤学ナノマテリアルの胎盤移行性と胎盤毒性, メジカルビュー社, ISBN:9784758317627, 2019/12
医薬品開発における創薬スクリーニング関連技術開発第6章標的たんぱく質の同定における手法と考え方, 長野一也,東阪和馬,辻野博文,角田慎一,堤康央, 情報機構, ISBN:9784865021806, 2019/12
分子進化技術によるサイトカイン機能改変体の創製とDDSへの展開, 長野一也,東阪和馬,堤康央, シーエムシー出版, ISBN:9784781313337, 2018/04
ナノ医薬品の安全性評価での留意点, 東阪和馬,長野一也,堤康央, DDS先端技術の製剤への応用開発, 2017/06
薬剤学を基盤とした、ナノマテリアルの安全性評価研究, 長野一也,東阪和馬,堤康央, 薬剤学, 2017/04
皮膚細胞を用いた化粧品中ナノマテリアルの安全性評価, 衛藤舜一,東阪和馬,長野一也,堤康央, Fragrance Journal, 2017/04
DOHaD仮説に基づいたナノマテリアルの生殖発生毒性, 東阪和馬,長野一也,堤康央, 産科と婦人科, 2017/04
Reproductive and developmental effects of nanomaterials, Morishita Y,Yoshioka Y,Higashisaka K,Tsutsumi Y, Springer, ISBN:9784431557319, 2016/01
Biological Effects of Fibrous and Particulate Substances, Hirai T,Yoshioka Y,Higashisaka K,Tsutsumi Y, Springer, ISBN:9784431557326, 2016/01
安全・安心な最先端医薬としてのDDS開発とレギュラトリーサイエンス-ナノDDSの安全性評価・確保の現状と今後., 応用が拡がるDDS 人体環境から農業・家電まで, 東阪和馬,堤康央, NTS出版, 2013/07
ターゲッティング-高分子バイオコンジュゲート化医薬品., 応用が拡がるDDS 人体環境から農業・家電まで, 吉岡靖雄,堤康央, NTS出版, 2013/07
遺伝子医薬品・タンパク医薬品・ホルモン製剤-タンパク医薬・ホルモン製剤・核酸医薬の応用に向けたDDS技術の動向と実用化の可能性., 『～医療ニーズ、規制、最新技術、薬価、事業戦略、事例をふまえた～DDS製剤の開発・評価と実用化手法』, 鎌田春彦,堤康央,角田慎一, 技術情報協会, 2013/03
ナノ安全科学研究の最前線., 『開発/製造、登録/輸出入における世界の化学品規制・ルールの解釈と違反回避のための実務, 市橋宏一,平井敏郎,吉岡靖雄,堤康央, 技術情報協会, 2012/12
細胞内薬物導入キャリアとしての細胞内移行ペプチドの応用技術, 向洋平,堤康央,中川晋作, 絵で見てわかるナノDDS, 2007/12
バイオ医薬品の品質・安全性評価 -第6節機能性人工タンパク質-(p.369-378), （株）エル・アイ・シー, 2007
ファージ表面提示法を駆使した機能性人工蛋白質の創製とDDSへの応用, 向洋平,堤康央, Bioベンチャー, 2004/11
向洋平,堤康央 : ファージ表面提示法を駆使した機能性人工タンパク質の創製とDDSへの応用., Bioベンチャー., 2004
堤康央, 吉岡靖雄, 真弓忠範医薬価値に優れた機能性人工タンパク質の網羅的かつ迅速同定システムとプロテオーム創薬への展開, 細胞工学, 2003
堤康央, 鎌田春彦, 真弓忠範機能化高分子キャリアの開発とプロテオーム創薬への展開, Bioベンチャー, 2003
堤康央, 真弓忠範高分子化医薬(PEG化製剤). ,, 血液･免疫･腫瘍, 2003
堤康央, 真弓忠範プロテオーム創薬にかなう機能性人工蛋白質の迅速創出とそのPEGylationへの展開., 蛋白質核酸酵素, 2003
PEGハイブリッド化によるTNF-αの抗腫瘍活性の増強, DDSの進歩(]G0002[):静岡DDS研究会矢内原昇編集, 1993
PEGylation of TNF-α drastically increases its anti-tumor potency., Progress in Drug Delivery System (]G0002[) : Biiomedical Research Foundation, Tokyo, 1993

Industrial Property Rights

潰瘍性大腸炎の予防または治療剤と新規フラーレン誘導体, 堤康央,吉岡靖雄,東阪和馬,増野匡彦,大江知之,山名修一,青島央江, JP2014053950, 出願日:2014/02/19
肺腺扁平上皮癌の腫瘍マーカー及び診断キット, 鎌田春彦,角田慎一,堤康央, 特許第5969777号, 特願2012-050629, 出願日:2012/03/07
炎症性腸疾患の予防または治療剤, 堤康央,吉岡靖雄,吉川友章,大島巧,小久保研,山名修一,青島央江, 特願2011-231446, 出願日:2011/10/21
TNFアンタゴニスト及びそれを有効成分とするTNF阻害剤, 真弓忠範,堤康央,中川晋作,太田恒孝, 特許第5366161号, 特願2011-196780, 出願日:2011/09/09
TNFアンタゴニスト及びそれを有効成分とするTNF阻害剤, 真弓忠範,堤康央,中川晋作,太田恒孝, 特願2010-227635, 出願日:2010/10/07
新規腫瘍マーカーを用いた乳癌の検査方法, 角田慎一,堤康央, 特願2009-060706, 出願日:2009/03/13
粘膜ワクチン用アジュバント, 角田慎一,堤康央,吉岡靖雄, 特願2009-055953, 出願日:2009/03/10
粘膜ワクチン用アジュバント, 角田慎一,堤康央,吉岡靖雄, 特許第5539660号, 特願2009-055953, 出願日:2009/03/10
生理活性複合体, 真弓忠範,堤康央,中川晋作,池上伯郎, 特許第4177604号, 特願2002-185387, 出願日:2002/06/26
細胞内物質導入ベクター, 今津進,中川晋作,久保一義,堤康央,真弓忠範,山田修, 特許第5001478号, 特願平9-357506, 出願日:1997/12/25
腫瘍血管内皮表面の抗原を認識するモノクローナル抗体, 真弓忠範,中川晋作,堤康央,大泉厳雄, 特願平9-029979, 出願日:1997/02/14
抗体、乳がんの治療に用いられる医薬組成物、腫瘍検査方法、及び、腫瘍検査用試薬, 角田慎一,長野一也,堤康央, 特許第5956424号, 特願2013-504572, 出願日:2012/03/14
インターフェロンα変異蛋白質とその用途, 真弓忠範,堤康央,中川晋作,谷合まどか,鳥越角二,栗本雅司, 特許第4815356号, 特願2006-544910, 出願日:2005/11/09
生理活性複合体, 真弓忠範,堤康央,中川晋作,谷合まどか,鳥越角二,藤井光清,山内宏,池田雅夫,栗本雅司, 特許第4866612号, 特願2005-515453, 出願日:2004/11/12
新規ウイルスベクター, 真弓忠範,中川晋作,堤康央,川崎紘一,前田光子,早川堯夫,水口裕之, 特許第4566129号, 特願2005-505035, 出願日:2004/02/17
細胞内薬物徐放化方法及び製剤
Intracellular delivery vector
Tumor-tissue endothelium-specific monoclonal antibody

Works

黄砂現象の環境・健康リスクに関する環境科学的研究, 2010 -
機能性抗体の作製, 2002 -
Creation of functional antibodeis, 2002 -

Awards

第10回日本学術振興会賞, 2013/12
Journal of Pharmaceutical Sciences (JPharmSci) 2013 Top Reviewer,, 2013
第2回大阪大学総長顕彰（研究部門）, 2013
Journal of Pharmaceutical Sciences (JPharmSci) 2012 Top Reviewer, 2012/09
平成23年国立大学法人大阪大学功績賞, 2011
2010 バイオビジネスコンペJAPAN 奨励賞, 2010/03
平成21年度国立大学法人大阪大学教育・研究功績賞, 2010/02
第9回日本DDS学会永井賞, 2009
日本薬学会奨励賞, 2004
日本薬剤学会奨励賞, 2004
日本薬剤学会奨励賞, 2004
日本薬学会奨励賞, 2004
日本薬学会近畿支部奨励賞, 1997
日本薬学会近畿支部奨励賞, 1997

Presentations

終わりに〜薬学的観点からのナノ・マイクロプラスチックの安全性評価〜, 堤康央,芳賀優弥,東阪和馬,淺原時泰,辻野博文, 日本薬学会第143年会, 2023/03
はじめに〜生体外微粒子としてのナノ・マイクロプラスチックの生体影響評価〜, 堤康央,辻野博文,淺原時泰,東阪和馬,芳賀優弥, 日本薬学会第143年会, 2023/03
食品に含有されるナノマテリアルの次世代影響等、安全性評価に関する研究, 堤康央, 遠山椿吉賞受賞講演, 2023/02
アカデミアにおけるRS人材の育成〜大阪大学を例に〜, 第96回日本薬理学会年会, 2022/11
薬学におけるレギュラトリーサイエンス研究教育と人材育成への取組〜大阪大学を一例に〜, 堤康央, 第12回レギュラトリーサイエンス学会学術大会, 2022/09
革新的医薬品・医療機器・再生医療製品実用化促進事業を足掛かりに, 堤康央, 第12回レギュラトリーサイエンス学会学術大会, 2022/09
大阪大学薬学部における新6年制への挑戦と現状, 堤康央, 第30回日本医療薬学会年会, 2020/11
品質保証〜毒性学/安全科学の視点から〜, 堤康央, 日本薬学会第140年会, 2020/03
大阪大学薬学部における新全6年制への挑戦, 堤康央, 日本薬剤学会第34年会, 2019/05
生体外微粒子の健康影響とその有効活用に向けて, 堤康央,長野一也,辻野博文,東阪和馬, 日本薬学会第139年会, 2019/03
微粒子の生体影響とその安全性確保〜脆弱な世代への健康影響と金属アレルギーを中心に〜, 堤康央, 第18回Nuss法漏斗胸手術手技研究会, 2018/11
薬学研究教育の現状と今後〜大阪大学の取組について〜., 堤康央, 神戸薬科大学大学院薬学研究科FD・SD研修会, 2018/06
細胞外微粒子に起因する生命現象の解明とその制御, 堤康央, 徳島大学研究クラスター講演会, 2018/01
細胞外微粒子のADMET解析とデリバリーへの展開, 堤康央, 先端医療振興財団講演会, 2017/12
革新的バイオ医薬の目指すべき安全性面からのアプローチ, 堤康央, 第7回日本安全性薬理研究会学術年会, 2016/02
ナノマテリアルの安全性研究の現状と今後, 堤康央, 大阪府立公衆衛生研究所創立記念講演会, 2015/11
脆弱な個体をも対象とした、経皮・吸入曝露後のナノ・サブナノ素材の挙動解析とハザード情報集積（ナノリスク解析基盤の構築）, 堤康央, 厚労科研ナノ研究者間意見交換会, 2015/10
我が国発のバイオ医薬の創出に向けて～抗体医薬にフォーカスして～, 堤康央, 関西ライフサイエンス・リーディングサイエンティストセミナー, 2015/09
アカデミア創薬の研究教育に係わる「阪大薬学丸」の挑戦, 日本薬学会第135年会, 2015/03
MicroRNA as a biomarker for the safety analysis of nanomaterials, SOT2012, 2012/03
The effect of in utero exposure to amorphous nanosilica particles on neonatal immune function and neurological function, SOT2012, 2012/03
Size-dependent aggravating-effect of amorphous silica nanoparticles on atopic dermatitis, SOT2012, 2012/03
Hemopexin as biomarkers for analyzing the biological responses associated with exposure to silica nanoparticles, SOT2012, 2012/03
高脂肪食摂取マウスに対するナノシリカの影響, 日本薬学会第132年会, 2012/03
TNFR2の機能解明に向けたヒトTNFR2指向性変異体の創製とその応用, 日本薬学会第132年会, 2012/03
大腸がん転移診断・治療法の開発を目指した転移関連たんぱく質の探索, 日本薬学会第132年会, 2012/03
ナノマテリアル暴露による細胞内活性酸素種の生成機序に関する検討, 日本薬学会第132年会, 2012/03
創傷治癒における線維芽細胞への非晶質ナノシリカの影響, 日本薬学会第132年会, 2012/03
非晶質ナノシリカは胃潰瘍および創傷の治癒を阻害する, 日本薬学会第132年会, 2012/03
非晶質ナノシリカの精子頭部への結合による精子運動性の低下, 日本薬学会第132年会, 2012/03
非晶質ナノシリカ暴露による摘出ラット胸部大動脈の弛緩作用, 日本薬学会第132年会, 2012/03
非晶質ナノシリカによる細胞内カルシウムイオンの動態変化, 日本薬学会第132年会, 2012/03
非晶質ナノシリカの安全性担保/向上に向けた基礎情報の収集, 日本薬学会第132年会, 2012/03
マウスモデルにおけるサブナノ銀粒子の経口ハザード同定, 日本薬学会第132年会, 2012/03
ナノ白金の授乳期投与が母体に及ぼす影響評価, 日本薬学会第132年会, 2012/03
ナノマテリアルの慢性影響に対する安全性評価マーカーの探索―非晶質ナノシリカの連日曝露による生体影響評価―, 日本薬学会第132年会, 2012/03
非晶質ナノシリカの経鼻免疫毒性に関する基礎情報の収集, 日本薬学会第132年会, 2012/03
サブナノ素材の安全性評価に向けた基礎的検討～サブナノ白金の経鼻曝露における生体影響評価～, 日本薬学会第132年会, 2012/03
新規ナノ薬物送達担体の開発を目指した細胞内ナノ動態に関する基礎的検討, 日本薬学会第132年会, 2012/03
ナノ・サブナノ素材の口腔毒性に関する基礎情報の収集, 日本薬学会第132年会, 2012/03
新規乳がん分子標的治療薬の開発を目指したEph receptor A10の創薬ターゲットとしての有用性評価, 日本薬学会第132年会, 2012/03
ナノ安全科学的視点からのサブナノ白金の妊娠期曝露による胎仔影響の基礎解析, 日本薬学会第132年会, 2012/03
抗炎症機能を有する水酸化フラーレンの開発とその薬物治療の最適化への展開, 日本薬学会第132年会, 2012/03
ナノ安全科学におけるmicroRNAの安全性バイオマーカーとしての有用性評価に向けた基礎検討, 日本薬学会第132年会, 2012/03
非晶質ナノシリカの表面性状と発生毒性の連関解析に向けた基礎検討, 日本薬学会第132年会, 2012/03
経口投与したサブナノ白金の腎障害誘発性に関する基礎検討, 日本薬学会第132年会, 2012/03
サブナノ白金の妊娠期投与による次世代影響に関する基礎的検討, 日本薬学会第132年会, 2012/03
非晶質ナノシリカの経皮曝露がアトピー性皮膚炎に与える影響, 日本薬学会第132年会, 2012/03
ナノマテリアルの安全性確保に向けた非晶質ナノシリカの表面物性と起炎性の連関解明, 日本薬学会第132年会, 2012/03
Exosome由来膜たん白質のプロテオーム解析による新規肺がん血液診断マーカーの探索, 日本薬学会第132年会, 2012/03
安全なナノ香粧品の開発に向けたナノマテリアルの安全性評価, 日本薬学会第132年会, 2012/03
Development of biomarkers using a proteomics analysis toward ensuring safety of nanomaterials, 2012/01
Effect of surface properties of nanosilica on their in vitro safety, 2012/01
VEGFR2に対する抗体を用いた腫瘍イメージング, 第11回放射性医薬品・画像診断薬研究会, 2011/12
Fundamental assessment for clarification of Relationship between Asian dust and influenza infection-1; Potential immunotoxicity of Asian dust for the future risk-analysis, SETAC North America 32nd Annual Meeting, 2011/11
Promotion of antigen-specific IgE production by intranasally-administrated nanosilica particles in mice, SETAC North America 32nd Annual Meeting, 2011/11
Fundamental assessment for clarification of Relationship between Asian dust and influenza infection-2; Biodistribution and inflammatory effects of Asian dust for the future risk-analysis, SETAC North America 32nd Annual Meeting, 2011/11
Development of biomarkers of nanomaterials toward newly strategies ensuring safety and efficacy of nanomedicine, 2011/11
Safety evaluation of amorphous silica nanoparticles following intranasal exposure: Potential applications for nanoparticle-based intranasal drug delivery, 2011/11
Safety analysis of silica particle for development of nanomedicine ~Developmental toxicity on placenta~, 2011/11
Creation of mouse TNFR2-selective TNF mutant using phage display system, 9th Joint Meeting of ICS-ISICR, 2011/10
Biological and structural characterization of human TNFR2-selective TNF mutants, 9th Joint Meeting of ICS-ISICR, 2011/10
生殖細胞および血管内皮細胞への非晶質ナノシリカの影響評価, 第61回日本薬学会近畿支部総会・大会, 2011/10
C60フラーレンの経口ナノ医薬品としての開発に向けた安全性評価, 第61回日本薬学会近畿支部総会・大会, 2011/10
非晶質ナノシリカによるアトピー性皮膚炎の悪化, 第61回日本薬学会近畿支部総会・大会, 2011/10
安全なナノマテリアルの開発に向けた非晶質ナノシリカの免疫系への影響評価―好中球数の増加と起炎性との連関解析に向けて―, 第61回日本薬学会近畿支部総会・大会, 2011/10
胎仔期の非晶質ナノシリカ曝露が新生仔に及ぼす影響の評価―新生仔の免疫機能、神経機能の基礎的検討―, 第61回日本薬学会近畿支部総会・大会, 2011/10
ES細胞を用いた非晶質ナノシリカの発生影響に関する基礎的検討, 第61回日本薬学会近畿支部総会・大会, 2011/10
サブナノ新素材の生体影響に関する基礎的検討―経鼻曝露時の安全性について―, 第61回日本薬学会近畿支部総会・大会, 2011/10
安全なナノマテリアルの開発に資する非晶質ナノシリカの生殖発生毒性評価, 第61回日本薬学会近畿支部総会・大会., 2011/10
TNFR2の機能解明に向けたマウスTNFR2指向性アゴニストの創製, 第61回日本薬学会近畿支部総会・大会, 2011/10
食餌成分との食べ合わせを考慮した非晶質ナノシリカの安全性評価, 第61回日本薬学会近畿支部総会・大会, 2011/10
サブナノ白金の消化管吸収性―snPtの体内吸収性評価―, 第61回日本薬学会近畿支部総会・大会, 2011/10
The intradermal injections of amorphous nanosilica particles size-dependently aggravate the atopic dermatitis, 2011/10
Proteomic profiling of proteins associated with metastasis in colorectal cancer cell lines, 2011/10
Functional analysis of a novel breast cancer related protein, ephrin receptor A10, The 2011 European Multidisciplinary Cancer Congress, 2011/09
Possibility of Ephrin receptor A10 as a drug target in triple negative breast cancer, The 2011 European Multidisciplinary Cancer Congress, 2011/09
The relationship between oxysterol binding protein like 5 and calumenin during lymph node metastasis, The 2011 European Multidisciplinary Cancer Congress, 2011/09
The search for a biomarker of hepatic injury expressed by sinusoidal endothelial cells, HUPO2011, 2011/09
Modifying the antigen-immunization schedule improves the variety of monoclonal antibodies obtained from immune-phage antibody libraries against HIV-1 Nef and Vif, HUPO2011, 2011/09
Expression of Annexin A4 is related to cisplatin-susceptibility in mesothelioma cells, HUPO2011, 2011/09
食品中ナノマテリアルの安全性評価：安全なナノマテリアルの創製に向けた次世代影響評価について, 第102回日本食品衛生学会学術講演会, 2011/09
安全なナノマテリアルの創製に向けた次世代影響評価：妊娠後期曝露の胎仔影響に焦点を絞って, 第18回日本免疫毒性学会学術大会, 2011/09
Systemic distribution of amorphous nanosilica following topical application, EuroTox2011, 2011/08
Development of biomarkers for ensuring safety of nanomaterials, EuroTox2011, 2011/08
In vitro evaluation of the embryotoxic potency of amorphous nanosilica, EuroTox2011, 2011/08
Postnatal effects of prenatal treatment of amorphous nanosilica, EuroTox2011, 2011/08
Effect of surface properties of nanosilica on their in vitro safety, EuroTox2011, 2011/08
The safety assessment of amorphous nanosilica following dermal exposure, EuroTox2011, 2011/08
Solution of the Structure of the TNF-TNFR2 Complex, International Union of Crystallography (IUCr) 2011, 2011/08
Creation of TNFR1-selective mutant TNF with antagonistic activity., XXIII Congress of the International Society of Thrombosis and Haemostasis, 2011/07
イオンモビリティ質量分析装置を用いたバイオ医薬の安全性・品質評価法に関する基礎検討, 第９回日本ヒトプロテオーム機構学術集会, 2011/07
ナノシリカの妊娠マウス投与が胎盤に与える影響., 第47回日本周産期・新生児医学会学術集会, 2011/07
非晶質ナノシリカによる細胞内カルシウムイオンの動態変化, 第38回日本トキシコロジー学会学術年会, 2011/07
ヒト健康へのリスク解析に資する黄砂の免疫毒性に関する基礎的評価, 第38回日本トキシコロジー学会学術年会, 2011/07
非晶質ナノシリカの胎仔期曝露による次世代影響の基礎的検討, 第38回日本トキシコロジー学会学術年会, 2011/07
安全なナノマテリアルの開発およびその支援に向けて―トキシコプロテオミクスによる安全性評価マーカーの探索―, 第38回日本トキシコロジー学会学術年会, 2011/07
安全なナノマテリアルの開発に向けて―非晶質ナノシリカの生殖発生への影響評価と安全性情報の集積―, 第38回日本トキシコロジー学会学術年会, 2011/07
非晶質ナノシリカがアトピー性皮膚炎の発症・悪化に与える影響, 第38回日本トキシコロジー学会学術年会, 2011/07
非晶質ナノシリカの消化管吸収性と生体影響に関する基礎的解析, 第38回日本トキシコロジー学会学術年会, 2011/07
経鼻経路に着目した安全なナノマテリアル開発を目指した基礎的解析, 第38回日本トキシコロジー学会学術年会, 2011/07
非晶質ナノシリカの血液凝固促進機構に関する基礎情報の集積, 第38回日本トキシコロジー学会学術年会, 2011/07
Toxico-proteomic analysis and identification of biomarkers for nano-safety science, 2011/06
ナノ化粧品の安全性確保および安全なナノ化粧品の開発に向けて：非晶質ナノシリカの生体内・細胞内局在解析と安全性情報の収集, 第36回日本香粧品学会, 2011
プロテオミクスによる大腸がん転移関連たんぱく質の探索, 第20回日本がん転移学会学術集会・総会, 2011
有効かつ安全な経口ナノ医薬の開発に向けたC60フラーレンの安全性評価, 第27回日本DDS学会学術集会, 2011
新規乳がん関連たんぱく質Ephrin receptor A10の機能解析と創薬標的としての有用性評価, 第27回日本DDS学会学術集会, 2011
乳がん関連たんぱく質Ephrin receptor A10に対する抗体医薬開発に向けた基礎検討, 第27回日本DDS学会学術集会, 2011
標的分子特異的な細胞内薬物送達を目指した細胞内侵入抗体の基礎的特性評価, 日本薬剤学会第26年会, 2011
Effect of Surface Properties of Silica Nanoparticles on Their Cytotoxicity and Cellular Distribution, ICMAT 2011-Symposium F, 2011
The importance of systemic nanotoxicological and toxicokinetic analysis for ensuring the safety of nanomaterials, Gordon Research conference, 2011
Amorphous nanosilica induce endocytosis-dependent ROS generation and DNA damage in human keratinocyte, SETAC Europe 21st Annual Meeting, 2011
Evaluation of immune modulating effect of orally administrated amorphous silica nanoparticles, SETAC Europe 21st Annual Meeting, 2011
The safety assessment of amorphous nanosilica on developmental and reproductive toxicity, SETAC Europe 21st Annual Meeting, 2011
Evaluation of biological response against various types of carbon nanotubes, SETAC Europe 21st Annual Meeting, 2011
Creation of mouse TNFR2 selective mutant TNF for functional analysis of TNFR2, 13th International TNF Conference, 2011
Selective inhibition of TNFR1 by mutant TNF with antagonistic activity is effective in the treatment of experimental autoimmune encephalomyelitis, 13th International TNF Conference, 2011
Biodistribution and reproductive toxicity of nanosilica for ensuring the safety of nanomaterials, SOT 2011, 2011
Distribution in the testis and reproductive effects of nanosilica, SOT 2011, 2011
Acute phase proteins as biomarkers for predicting the exposure and safety of nanomaterials, SOT 2011, 2011
Size-dependent immune-modulating effect of amorphous nanosilica, SOT 2011, 2011
Effect of oral exposure of amorphous nanosilica on antigen-specific immune responses in the presence of chicken egg ovalbumin, SOT 2011, 2011
Amorphous nanosilica induces class I-restricted processing and presentation of exogenous antigens in murine dendritic cells, The 4th World Congress on Controversies in Urology (CURy2011), 2011
脂肪肝マウスに対するナノシリカの影響, 日本薬学会第131年会, 2011
抗体プロテオミクス技術による肺がんリンパ節転移関連分子の同定と機能解析, 日本薬学会第131年会, 2011
ナノシリカの電荷制御によるマウス精子へのナノ毒性軽減, 日本薬学会第131年会, 2011
ナノシリカはマウス精子頭部に結合し特有の毒性を発現させる, 日本薬学会第131年会, 2011
乳がんに対する新規創薬ターゲット候補Ephrin receptor A10の機能解析, 日本薬学会第131年会, 2011
TNFR2の機能解析に向けたマウスTNFR2指向性変異体の作製, 日本薬学会第131年会, 2011
Triple negative乳がんにおけるEphrin receptor A10の創薬ターゲットとしての可能性, 日本薬学会第131年会, 2011
ES細胞を用いたナノマテリアルのin vitro発生毒性評価に関する基礎的検討, 日本薬学会第131年会, 2011
経口ナノ医薬の開発を目指したC60フラーレンの安全性評価, 日本薬学会第131年会, 2011
ナノマテリアルの次世代影響評価に向けた非晶質ナノシリカの精巣機能障害性評価, 日本薬学会第131年会, 2011
黄砂の健康リスク解析を目指した免疫毒性に関する基礎的評価, 日本薬学会第131年会, 2011
ナノマテリアルの安全性評価に資するバイオマーカーの探索, 日本薬学会第131年会, 2011
非晶質ナノシリカを経鼻接種した際の生体影響の評価, 日本薬学会第131年会, 2011
非晶質ナノシリカの消化管吸収性と生体影響との基礎的解析, 日本薬学会第131年会, 2011
非晶質ナノシリカの皮内曝露とアトピー性皮膚炎の発症・悪化との連関追求, 日本薬学会第131年会, 2011
安全な非晶質ナノシリカの創製に向けた基礎情報の集積, 日本薬学会第131年会, 2011
非晶質ナノシリカの経口曝露における安全性評価, 日本薬学会第131年会, 2011
安全性確保を目指したナノマテリアルの生殖発生影響評価, 薬学会第131年会, 2011
ヒトの健康確保を目指したカーボンナノチューブの生体影響評価, 日本薬学会第131年会, 2011
Anti-inflammatory effects of TNFR1-selective antagonistic TNF mutant on murine collagen-induced arthritis., FIP Pharmaceutical Sciences 2010 World Congress, 2010
Expression and functional analysis of ephrin receptor A10 in triple negative breast cancer., 2010 FAPA CONGRESS, 2010
Identification and functional evaluation of RhoGDI as a metastasis-related protein in colorectal cancer., 2010 FAPA CONGRESS, 2010
Identification and evaluation of lymph node metastasis-related proteins in lung cancer by antibody proteomics technology., 2010 FAPA CONGRESS, 2010
THE POTENTIAL OF IL-1 FAMILY CYTOKINES AS MUCOSAL ADJUVANTS FOR NASAL INFLUENZA VACCINE, Joint Meeting of the International Cytokine Society (ICS) and the International Society for Interferon and Cytokine Research (ISICR), 2010
Anti-inflammatory effects of a novel TNFR1-selective antagonistic TNF mutant in experimental autoimmune encephalomyelitis mice., Joint Meeting of the International Cytokine Society (ICS) and the International Society for Interferon and Cytokine Research (ISICR), 2010
Proteomics-based analysis of non-alcoholic fatty liver disease (NAFLD) in mice., HUPO2010 World Congress, 2010
Identification of lymph node metastasis-related proteins in lung cancer by antibody proteomics technology., HUPO2010 World Congress, 2010
Identification of lymph node metastasis-related proteins in lung cancer by antibody proteomics technology., HUPO2010 World Congress, 2010
Conformational and functional analysis for quality control of protein drugs using ion mobility mass spectrometry., HUPO2010 World Congress, 2010
Amorphous nanosilicas induce size-dependent effect on antigen-presentation in murine dendritic cell line., 14th International Congress of Immunology., 2010
Anti-inflammatory effects of a TNFR1-selective mutant with antagonistic activity on established murine collagen-induced arthritis., 14th International Congress of Immunology., 2010
Characterization of Interleukin-1 family cytokines as an adjuvant for mucosal vaccine against influenza virus., 14th International Congress of Immunology., 2010
Safety evaluation of amorphous nanosilica when given as a single intravenous dose to mice., The XII International Congress of Toxicology., 2010
Safety assessment of nanomaterials: inflammatory responses of nanosilica with different sizes and surface properties., The XII International Congress of Toxicology., 2010
Identification and evaluation of tumor lymphatic endothelial cell-specific proteins by antibody proteomics technology., 21st Meeting of the European Association for Cancer Research., 2010
Identification and evaluation of novel breast cancer related biomarker proteins by antibody proteomics technology., 21st Meeting of the European Association for Cancer Research., 2010
Distribution analysis of nanosilica, major component of Asian dust, to the testis for the safety scientific assessment., The Asia/Pasific Chapter of Enviromental Toxicology and Chemistry 2010 Conferece (SETAC)., 2010
The safety scientific assessment of reproductive and developmental toxicity of nanosilica, major component of Asian dust., The Asia/Pasific Chapter of Enviromental Toxicology and Chemistry 2010 Conferece (SETAC)., 2010
Development of biomarkers for the safety scientific assessment of nanosilica, major component of Asian dust., The Asia/Pasific Chapter of Enviromental Toxicology and Chemistry 2010 Conferece (SETAC), 2010
Silica particle, major component of Asian dust, induces IL-1 production through NALP3 activation mediated by cathepsin B ., The Asia/Pasific Chapter of Enviromental Toxicology and Chemistry 2010 Conferece (SETAC)., 2010
Surface charge modification of silica nanoparticles reduces mouse sperm nanotoxicology., 第33回日本分子生物学会年会・第83回日本生化学会大会合同大会（BMB2010）, 2010
インフルエンザ経鼻ワクチンアジュバントとしてのIL-1 ファミリーの有用性評価, 第60回日本薬学会近畿支部総会･大会, 2010
ナノマテリアルの安全性確保に向けた非晶質ナノシリカの精巣移行性・精巣機能障害性の検討, 第60回日本薬学会近畿支部総会･大会, 2010
安全なナノマテリアルの創製に向けた安全性評価マーカーの探索, 第60回日本薬学会近畿支部総会･大会, 2010
非晶質ナノシリカの経皮影響に関する免疫学的解析, 第60回日本薬学会近畿支部総会･大会, 2010
非晶質ナノシリカの経口影響に関する基礎情報の収集, 第60回日本薬学会近畿支部総会･大会, 2010
ヒトの健康確保を目指したナノ安全科学研究とリスク解析への展開, 第60回日本薬学会近畿支部総会･大会, 2010
新規乳がん関連分子Ephrin receptor A10の機能解析とモノクローナル抗体の創製, 第60回日本薬学会近畿支部総会･大会, 2010
ナノマテリアルの安全性確保に向けて～非晶質ナノシリカの次世代への影響評価～, 第9回次世代を担う若手ファーマ・フォーラム2010, 2010
非晶質ナノシリカの経口曝露における免疫撹乱作用の解析, 第9回次世代を担う若手ファーマ・フォーラム2010, 2010
新規乳がん関連たんぱく質Ephrin receptor A10の同定および難治性乳がんに対する創薬ターゲットとしての有用性評価, 第9回次世代を担う若手ファーマ・フォーラム2010, 2010
ナノ含有食品の安全性確保および安全なナノ含有食品の開発に向けて：ナノ酸化チタンの形状と免疫系への影響., 第100回日本食品衛生学会学術講演会, 2010
新規乳がん関連蛋白質EphA10およびRREB-1の転移との連関解析, 第19回日本がん転移学会, 2010
TNFレセプターの機能解明に向けたマウスTNFR2指向性アゴニストの作製, 第26回日本DDS学会学術集会, 2010
抗HCV活性の向上を目指したIFN8構造変異体の創製, 第26回日本DDS学会学術集会, 2010
レセプター特異性に優れた機能性人工質蛋白質創出システムの開発, 第26回日本DDS学会学術集会, 2010
Ephrin receptor A10の新規乳がん創薬標的としての有用性評価, 第26回日本DDS学会学術集会, 2010
新規乳がん分子標的治療法の開発を目指したEphrin receptor A10に対するscFv抗体の創製, 第26回日本DDS学会学術集会, 2010
転移の制御を目指した肺がん関連蛋白質の探索, 第26回日本DDS学会学術集会, 2010
Immuno-conjugate製剤における抗体の細胞内侵入活性と抗腫瘍効果の連関解析, 第26回日本DDS学会学術集会, 2010
ナノマテリアルの安全性確保に向けて：非晶質ナノシリカが抗原特異的免疫誘導に与える影響, 第37回日本トキシコロジー学会学術年会, 2010
ナノマテリアルの安全性確保に向けて：表面性状に着目した非晶質ナノシリカの安全性向上に関する基礎情報, 第37回日本トキシコロジー学会学術年会, 2010
ナノマテリアルの安全性確保に向けて：非晶質ナノシリカの生殖発生への影響に関する基礎評価, 第37回日本トキシコロジー学会学術年会, 2010
ナノマテリアルの安全性確保に向けて：トキシコプロテオミクスによるナノマテリアルの安全性評価マーカーの探索に向けた基礎的検討, 第37回日本トキシコロジー学会学術年会, 2010
ナノマテリアルの安全性確保に向けて：ナノマテリアルの次世代影響評価に向けた精巣組織への移行性に関する基礎的検討, 第37回日本トキシコロジー学会学術年会, 2010
ナノマテリアルの安全性確保に向けて：非晶質ナノシリカの細胞内局在と安全性の連関に関する基礎情報の集積, 第37回日本トキシコロジー学会学術年会, 2010
非晶質ナノシリカの粒子特性と自然免疫応答の連関評価とそのメカニズム解析, 第37回日本トキシコロジー学会学術年会, 2010
ナノ化粧品の安全性確保および安全なナノ化粧品の開発に向けて-2:ナノマテリアルの粒子径と免疫系への影響, 第35回日本香粧品学会, 2010
ナノ化粧品の安全性確保および安全なナノ化粧品の開発に向けて-1：ナノマテリアルの表面性状が血液凝固系に与える影響, 第35回日本香粧品学会, 2010
Immune-conjugate製剤の開発に適う細胞内侵入抗体の効率的創製法の確立, 日本薬剤学会第25年会, 2010
ナノ含有食品の安全性確保および安全なナノ含有食品の開発に向けて-2：ナノマテリアルの表面電荷と免疫系への影響, 日本食品衛生学会第99回学術講演会, 2010
ナノ含有食品の安全性確保および安全なナノ含有食品の開発に向けて-1：ナノマテリアルの粒子サイズと血液凝固系への影響, 日本食品衛生学会第99回学術講演会, 2010
ファージ表面提示法を用いたマウスTNFR2指向性アゴニストの作製, 日本薬学会第130年会, 2010
インフルエンザ経鼻ワクチンアジュバントとしてのIL-1ファミリーの機能評価, 日本薬学会第130年会, 2010
新規バイオ医薬の開発を目指した腫瘍組織血管特異抗体の創製, 日本薬学会第130年会, 2010
プロテオミクスによる非アルコール性脂肪性肝疾患(NAFLD/NASH)のバイオマーカー探索, 日本薬学会第130年会, 2010
EphA10の新規乳がん関連バイオマーカー蛋白質としての有用性評価, 日本薬学会第130年会, 2010
血液凝固系に着目した非晶質ナノシリカの安全性評価, 日本薬学会第130年会, 2010
樹状細胞を標的としたナノシリカの経皮安全性評価, 日本薬学会第130年会, 2010
ナノシリカ粒子と薬物との併用によるナノマテリアルの安全性評価, 日本薬学会第130年会, 2010
Inflammatory responses of titanium dioxide with different size and properties., 49th Annual Meeting & ToxExpo (SOT2010), 2009
TNF superfamily member, TL1A, is a potential immunoregulator for development of mucosal vaccin., 9th International Conference on New Trends in Immunosuppression and Immunotherapy (IMMUNO2010), 2009
Intranasal immunization with mutant TNF modulates mucosal and systemic immune responses., 9th International Conference on New Trends in Immunosuppression and Immunotherapy (IMMUNO2010), 2009
Creation of lysine-deficient mutant lymphotoxin- with receptor selectivity by using phage display., 2009 Annual Meeting of the Society for Leukocyte Biology, International Cytokine Society, & International Society for Interferon and Cytokine Research (Tri-Society), 2009
Creation of mutant IFN-8 with enhanced anti-HCV activity using phage display technique., 2009 Annual Meeting of the Society for Leukocyte Biology, International Cytokine Society, & International Society for Interferon and Cytokine Research (Tri-Society), 2009
Frequent expression of TRAIL-R2 in human breast tumors revealed by antibody proteomics technology., 2009 Annual Meeting of the Society for Leukocyte Biology, International Cytokine Society, & International Society for Interferon and Cytokine Research (Tri-Society), 2009
TNFR1-selectivity improvement of mutant TNF with antagonistic activity., 2009 Annual Meeting of the Society for Leukocyte Biology, International Cytokine Society, & International Society for Interferon and Cytokine Research (Tri-Society), 2009
Cancer hazard of carbon nanotubes: size/shape-dependent induction of DNA damage and inflammation., 2009 Annual Meeting of the Society for Leukocyte Biology, International Cytokine Society, & International Society for Interferon and Cytokine Research (Tri-Society), 2009
Mast cells are required for intereukin-18 dependent mucosal immune responses., 2009 Annual Meeting of the Society for Leukocyte Biology, International Cytokine Society, & International Society for Interferon and Cytokine Research (Tri-Society), 2009
Characterization of mucosal and systemic immune responses elicited by interleukin cytokines as mucosal adjuvant against influenza virus., 2009 Annual Meeting of the Society for Leukocyte Biology, International Cytokine Society, & International Society for Interferon and Cytokine Research (Tri-Society), 2009
Creation and X-ray structural analysis of TNFR1-selective mutant TNF with antagonistic activity., HUPO 8th Annual World Congress, 2009
Development of an anti-tumor blood vessel specific antibody using phage antibody library., HUPO 8th Annual World Congress, 2009
Search for tumor-related biomarker proteins by antibody proteomics technology., HUPO 8th Annual World Congress, 2009
Identification of candidate proteins related to lymph node metastasis by antibody proteomics technology., HUPO 8th Annual World Congress, 2009
Hepatotoxicity of silica nanoparticles in mice., The 46th Congress of the European Societies of Toxicology (EuroTox), 2009
Nanosilicas with different sizes and surface charges induce different profiles of cytokine production on macrophages., The 46th Congress of the European Societies of Toxicology (EuroTox), 2009
Urban aerosol directly stimulates antigen presentation cells in vitro and cause airway inflammation in vivo., The 46th Congress of the European Societies of Toxicology (EuroTox), 2009
Differential acute toxicity and toxicokinetics of amorphous nanosilicas: The role of surface physicochemical properties., The 46th Congress of the European Societies of Toxicology (EuroTox), 2009
Evaluation of size-dependent intracellular distribution and genotoxicity of amorphous nanosilicas in human keratinocytes., The 46th Congress of the European Societies of Toxicology (EuroTox), 2009
Evaluation of size-dependent acute toxicity and toxicokinetics of amorphous nanosilicas., The 46th Congress of the European Societies of Toxicology (EuroTox), 2009
In vitro nanotoxicological study of silica nanoparticles using dermal cell lines., The 46th Congress of the European Societies of Toxicology (EuroTox), 2009
On resin deglycosylation and cysteine modification improve sequence coverage of biomarker proteins., 18th International Mass Spectrometry Conference, 2009
Antibody proteomics technology for efficient screening of tumor-related proteins using phage antibody library., Biomarker World Congress 2009, 2009
Creation of mutant lymphotoxins with enhanced bioactivities by phage display technique., 12th International TNF Conference, 2009
Creation of novel technology to produce mutant TNF with improved receptor selectivity using phage display technique with gene shuffling methods., 12th International TNF Conference, 2009
Identification of new candidates as mucosal vaccine adjuvant in TNF superfamily cytokines., 12th International TNF Conference, 2009
Evaluation of efficacy of mutant TNF as a mucosal vaccine adjuvant against HIV-1 and influenza virus., Evaluation of efficacy of mutant TNF as a mucosal vaccine adjuvant against HIV-1 and influenza virus., 2009
Effective treatment of established murine collagen-induced arthritis with a novel TNFR1-selective antagonistic mutant TNF., 12th International TNF Conference, 2009
ナノマテリアルの物性ー動態ー安全性の連関追求と健康確保に向けて, 大阪大学大学院ＧＰ健康環境リスクマネージメント専門家育成シンポジウム, 2009
Mast cells are essential for inducing mucosal immune responses by interleukin-18, 第39回日本免疫学会学術集会, 2009
Characterization of mucosal and systemic immune responses elicited by interleukin cytokines as mucosal vaccine adjuvant against influenza virus, 第39回日本免疫学会学術集会, 2009
Urban aerosol directly stimulates antigen presentation cells in vitro and cause airway inflammation in vivo, 第39回日本免疫学会学術集会, 2009
Antibody-drug conjugateの開発に適う細胞内侵入抗体の効率的探索法, ファーマバイオフォーラム 2009, 2009
抗体プロテオミクス技術による乳がん関連蛋白質の同定と機能評価, ファーマバイオフォーラム 2009, 2009
インフルエンザ経鼻ワクチンのためのサイトカインアジュバントの開発, ファーマバイオフォーラム 2009, 2009
安全確保に向けた非晶質ナノシリカの生殖発生毒性に関する検討, ファーマバイオフォーラム 2009, 2009
抗体プロテオミクス技術によるリンパ節転移関連蛋白質の探索, 第59回日本薬学会近畿支部総会・大会, 2009
抗体プロテオミクス技術よる乳がん関連バイオマーカーの探索とその評価, 第59回日本薬学会近畿支部総会・大会, 2009
薬学領域におけるナノマテリアルの安全性確保研究～ナノマテリアルの体内相互作用解析と安全性との連関追求～, 第59回日本薬学会近畿支部総会・大会, 2009
C型肝炎の克服を目指した高機能化IFN8構造変異体の創製, 第59回日本薬学会近畿支部総会・大会, 2009
アンタゴニスト活性を有したTNFR1指向性変異体の新規自己免疫疾患治療薬としての有用性評価, 第59回日本薬学会近畿支部総会・大会, 2009
ファージ表面提示法を駆使した活性増強型TNF変異体の創出とその特性, 第82回日本生化学会大会, 2009
ナノマテリアルの安全確保に向けて-6 表面修飾ナノシリカの安全性評価と安全なナノマテリアルの開発支援, 第98回日本食品衛生学会学術講演会, 2009
ナノマテリアルの安全確保に向けて-5 ナノマテリアルの動態特性と生殖発生毒性, 第98回日本食品衛生学会学術講演会, 2009
ナノマテリアルの安全確保に向けて-4 ナノマテリアルの動態特性と免疫毒性, 第98回日本食品衛生学会学術講演会, 2009
ナノマテリアルの安全確保に向けて-3 ナノマテリアルの細胞内動態と遺伝毒性, 第98回日本食品衛生学会学術講演会, 2009
ナノマテリアルの安全確保に向けて-2 ナノマテリアルの相互作用解析と急性毒性・肝毒性機構の追求, 第98回日本食品衛生学会学術講演会, 2009
ナノマテリアルの安全確保に向けて-1 ナノマテリアルの経皮吸収性・体内動態と急性毒性・肝毒性, 第98回日本食品衛生学会学術講演会, 2009
抗体プロテオミクス技術による肺がん関連バイオマーカー蛋白質の探索, 平成21年度がん特定若手研究者ワークショップ, 2009
抗体プロテオミクス技術による肺がんリンパ節転移関連蛋白質の探索2, 第18回日本がん転移学会学術集会, 2009
抗体プロテオミクス技術による肺がんリンパ節転移関連蛋白質の探索1, 第18回日本がん転移学会学術集会, 2009
低容量の化学発がん物質処置によるin vitro transformation感受性の低下, 第36回日本トキシコロジー学会学術年会, 2009
新規ミトコンドリアDNA損傷の簡易解析法の開発, 第36回日本トキシコロジー学会学術年会, 2009
ナノマテリアルのマウスにおける細胞内局在性に関する研究, 第36回日本トキシコロジー学会学術年会, 2009
非結晶性ナノシリカの自然免疫抑制作用に関する検討, 第36回日本トキシコロジー学会学術年会, 2009
各種酸化チタンの起炎性評価とそのメカニズム解析, 第36回日本トキシコロジー学会学術年会, 2009
非結晶性シリカの粒子特性と起炎性の連関評価, 第36回日本トキシコロジー学会学術年会, 2009
カーボンナノチューブの発癌リスクに関する基礎的検討, 第36回日本トキシコロジー学会学術年会, 2009
都市大気粉塵のアレルギー疾患誘発メカニズムの解析, 第36回日本トキシコロジー学会学術年会, 2009
非結晶性ナノシリカの生殖発生毒性に関する検討, 第36回日本トキシコロジー学会学術年会, 2009
非結晶性ナノシリカの表面物性と有害性発現との連関評価, 第36回日本トキシコロジー学会学術年会, 2009
非結晶性ナノシリカの皮膚細胞に対する遺伝毒性作用, 第36回日本トキシコロジー学会学術年会, 2009
ナノシリカのin vitro安全性評価における血清蛋白質の作用の解析, 第36回日本トキシコロジー学会学術年会, 2009
ファージ表面提示法を用いた抗腫瘍組織血管抗体の創製とその特性評価, 第25回日本DDS学会学術集会, 2009
生物学的DDSによる活性増強型TNF変異体の創出とその粘膜ワクチンアジュバントとしての有用性評価, 第25回DDS学会, 2009
自己免疫疾患に対する有効性および安全性の向上を目指したTNFR1指向性アンタゴニストの改変, 第25回DDS学会, 2009
非結晶性ナノシリカの生殖発生毒性に関する検討, 日本先天異常学会第49回学術集会, 2009
抗HCV活性向上を目指したIFN8構造変異体の創製, 第74回日本インターフェロンサイトカイン学会, 2009
香粧品素材としての非結晶性ナノシリカの皮膚細胞に対する遺伝毒性評価と安全確保に向けて, 第34回日本香粧品学会, 2009
食品添加物としてのナノシリカの物性と生体影響の連関解析, 日本食品衛生学会第97回学術講演会, 2009
イオンモビリティー質量分析法を用いた蛋白質医薬品の品質管理に向けた基礎検討, 第9回日本蛋白質科学会年会, 2009
イオンモビリティー質量分析法による蛋白質医薬品の構造と活性の連関解析, 第57回日本質量分析総合討論会, 2009
活性増強型TNF変異体の粘膜ワクチンアジュバントへの応用, 日本薬学会第129年回, 2009
疾患プロテオミクスからバイオマーカーの創出へ－抗体プロテオミクス技術の確立とがん関連マーカーの探索－, 日本薬学会第129年回, 2009
ナノシリカ粒子と化学物質の併用によるナノマテリアルの安全性評価, 日本薬学会第129年回, 2009
球状シリカ粒子の肝傷害性に及ぼす粒子径の影響, 日本薬学会第129年回, 2009
球状ナノシリカ粒子の肝傷害性に対する表面荷電の影響, 日本薬学会第129年回, 2009
非結晶性ナノシリカの物性と有害性発現との連関評価, 日本薬学会第129年回, 2009
各種酸化チタンの起炎性評価及びそのメカニズム解析, 日本薬学会第129年回, 2009
ナノシリカの皮膚透過性と経皮リスクに関する基礎検討, 日本薬学会第129年回, 2009
非結晶性ナノシリカの粒子サイズと遺伝毒性との連関解析, 日本薬学会第129年回, 2009
カーボンナノチューブの物性と発癌リスクとの連関評価, 日本薬学会第129年回, 2009
ナノシリカ粒子頻回投与によるナノマテリアルの安全性評価, 日本薬学会第129年回, 2009
都市大気粉塵に対する抗原提示細胞の免疫応答解析, 日本薬学会第129年回, 2009
新規素材として期待されるナノマテリアルの自然免疫攪乱作用に関する検討, 日本薬学会第129年回, 2009
C型肝炎の克服を目指した高機能化IFNα8構造変異体の創製, 日本薬学会第129年回, 2009
抗体プロテオミクスによる乳癌バイオマーカーの探索, 日本薬学会第129年回, 2009
TNFSF14/LIGHTによる効率的な腫瘍特異的免疫応答の惹起と抗腫瘍効果に関する検討, 日本薬学会第129年回, 2009
球状ナノシリカ粒子の急性肝傷害機構解析, 日本薬学会第129年回, 2009
安全かつ有効な自己免疫疾患治療薬の開発を目指したTNFR1指向性変異体の創出, 日本薬学会第129年回, 2009
ナノマテリアルの生体影響の評価及びトキシコプロテオミクスによる安全性マーカーの探索, 日本薬学会第129年会, 2009
Nanosilicas with various surface potential induce the different profile of cytokine production on macrophage., Society of Toxicology 48th Annual Meeting & ToxExpo, 2008
Evaluation of safety and efficacy of TNFR1-selective antagonistic mutant TNF as a novel anti-inflammatory drug., Society of Toxicology 48th Annual Meeting & ToxExpo, 2008
Influence of physicochemical properties of nano-silica particles on in vivo toxicity., Society of Toxicology 48th Annual Meeting & ToxExpo, 2008
Evaluation of size-dependent biological behavior of nano-silicas., Society of Toxicology 48th Annual Meeting & ToxExpo, 2008
Relationship between regulatory T cell infiltration and progression of different tumors assessed by high-density tissue microarray., 7th Joint Conference of the Intenational Society for Interderon and Cytokine Research and International Cytokine Society., 2008
LIGHT induces the anti-tumor effect by activating the tumor specific immune response., FIMSA 2008, 2008
Creation of TNFR1-Selective Mutant Lymphotoxin-Alpha Using Phage Display System., FIMSA 2008, 2008
IDENTIFICATION OF NEW CANDIDATES AS MUCOSAL VACCINE ADJUVANT IN TNF SUPERFAMILY CYTOKINES., FIMSA 2008, 2008
Structure-function relationship of tumor necrosis factor (TNF) and its receptor interaction based on 3D structural analysis of a fully active TNFR1-selective TNF mutant., 7th Joint Conference of the Intenational Society for Interderon and Cytokine Research and International Cytokine Society, 2008
MUTANT TNF ELICITS TH2-TYPE RESPONSES FOR ENHANCED MUCOSAL IMMUNITY., 7th Joint Conference of the Intenational Society for Interderon and Cytokine Research and International Cytokine Society., 2008
Creation of mutant TNF- with TNF receptor-1 selective antagonistic activity for the development of a novel autoimmune disease drug., 7th Joint Conference of the Intenational Society for Interderon and Cytokine Research and International Cytokine Society., 2008
Fine tuning of receptor-selectivity for tumor necrosis factor-α using a phage display system with one-step competitive-subtractive panning., 7th Joint Conference of the Intenational Society for Interderon and Cytokine Research and International Cytokine Society, 2008
Effect of nanomaterials on the induction of autophagy., Nanotoxicology - 2nd International Conference., 2008
Imaging and proteomics analysis for studying size-dependent biological behavior of nanosilicas., Nanotoxicology - 2nd International Conference, 2008
g of human lymphatic endothelial cells for analyzing lymphangiogenesis., HUPO 7th Annual World Congress Amsterdam 2008, 2008
r efficiently screening tumor-related proteins using antibody proteomics., HUPO 7th Annual World Congress Amsterdam 2008, 2008
Proteomics and imaging analysis for size-dependent biological behavior of silica-nanoparticles., HUPO 7th Annual World Congress Amsterdam 2008, 2008
Analysis of size-dependent biological behavior of silica nanoparticles by imaging and toxicoproteomics., 5th SETAC World Congress, 2008
Evaluation of genotoxic risk and oxidative DNA damage in human keratinocytes exposed to amorphous nano-silica., 第37回日本環境変異原学会, 2008
Influence of physicochemical properties of nano-silica particles on in vivo biologic behavior (2)., 第37回日本環境変異原学会, 2008
Influence of physicochemical property of nano-silicas on in vivo biological behavior (1), 第37回日本環境変異原学会, 2008
抗体プロテオミクスによるがんリンパ節転移マーカーの探索., 第31回日本分子生物学会年会・第81回日本生化学会大会合同大会, 2008
Identification of new candidates as mucosal vaccine adjuvant in TNF superfamily cytokines., 第38回日本免疫学会・学術集会, 2008
A bioactive mutant TNF (mTNF-K90R) elicited mucosal and systemic immunity against HIV-1 gp120 and influenza virus hemagglutinin., 第38回日本免疫学会・学術集会, 2008
抗体プロテオミクスによる乳がんマーカーの探索., ファーマバイオフォーラム2008, 2008
新規自己免疫疾患治療薬の開発を目指したTNFR1指向性アンタゴニストの創出., ファーマバイオフォーラム2008, 2008
活性増強型TNF変異体の粘膜ワクチンアジュバントへの応用., ファーマバイオフォーラム2008, 2008
活性増強型 TNF構造変異体の粘膜ワクチンアジュバントへの応用., 第22回日本エイズ学会学術集会, 2008
アンタゴニスト活性を有したTNFR1指向性変異体の新規自己免疫疾患治療薬としての有用性評価., 第58回日本薬学会近畿支部総会・大会, 2008
Antibody-based proteomics for efficient discovery and validation of tumor biomarkers., 第67回日本癌学会学術総会, 2008
TNFスーパーファミリーに着目した粘膜ワクチンアジュバント能の体系的評価., 第56回日本ウイルス学会学術集会, 2008
アンタゴニスト活性を有するI型受容体指向性TNF変異体の評価：関節リウマチモデルに対する治療効果および安全性の検討., 第24回DDS学会, 2008
ナノシリカの体内動態と生体影響に関する基礎的検討., 第35回日本トキシコロジー学会学術年会, 2008
ナノマテリアルの医薬品への展開とリスク Overview, 日本薬学会第128年会, 2008
抗体プロテオミクスによるリンパ管新生関連分子の探索と機能評価に向けて, 日本薬学会第128年会, 2008
アンタゴニスト活性を有する I 型受容体指向性 TNF 変異体の評価(1) : 関節リウマチモデルに対する治療効果の検討, 日本薬学会第128年会, 2008
免疫制御技術の開発に向けた制御性 T 細胞の抗体プロテオミクス研究, 日本薬学会第128年会, 2008
活性増強型 TNF 変異体の粘膜ワクチンアジュバントとしての応用, 日本薬学会第128年会, 2008
ナノシリカの医薬品/香粧品基材としての安全性評価(2) : 細胞内局在解析, 日本薬学会第128年会, 2008
ナノシリカの医薬品/香粧品基材としての安全性評価(1) : トキシコプロテオーム解析, 日本薬学会第128年会, 2008
疾患関連蛋白質の同定およびこれらに対する抗体を一挙かつ短期間で網羅的作製できる抗体プロテオミクスの確立, 日本薬学会第128年会, 2008
創薬プロテオミクスの実現に叶う機能性人工蛋白質の迅速創出技術の開発, 日本薬学会第128年会, 2008
新規 Protein Transduction Domain peptide の細胞内 DDS キャリアーとしての特性解析, 日本薬学会第128年会, 2008
Development of the valuable cell line which evaluates the bioactivity through TNFR2 using chimeric receptor strategy, 15th Annual Meeting of the International Cytokine Society, 2007
Creation of TNF receptor1-selective mutant TNF using phage display system, 15th Annual Meeting of the International Cytokine Society, 2007
Site-specific PEGYlation of a lysine-deficient TNF superfamily with full bioactivity, 15th Annual Meeting of the International Cytokine Society, 2007
Simultaneous identification of tumor-specific proteins and their antibodies by combining a proteomics technique and phage display library, 15th Annual Meeting of the International Cytokine Society, 2007
Creation of bioactive Lysine-deficient tumor necrosis factor for antitumor therapy, HUPO 6th Annual World Congress, 2007
Arsenic trioxide alters expression and oxidative modification of the proteome in leukemic cells, HUPO 6th Annual World Congress, 2007
Development of a novel therapeutic approach using an intracellular targeting strategy with membrane-permeable peptides, HUPO 6th Annual World Congress, 2007
Crystal structure of the receptor subtype I selective antagonistic TNF revealed its molecular basis as the proteo-antagonist, HUPO 6th Annual World Congress, 2007
An efficient method for the production of monoclonal antibodies to tumor-related proteins using a combination of phage display library and 2-dimensional differential gel electrophoresis, HUPO 6th Annual World Congress, 2007
Creation of TNFR1-selective mutant TNF using phage display system, Pharmaceutical Sciences World Congress, 2007
血管新生阻害剤を用いたリンパ管新生シグナル伝達経路の解析, 第30回日本分子生物学会年会・第80回日本生化学会合同大会, 2007
Intranasal immunization with mutant TNF induces antigen specific mucosal and systemic immune responses in mice, 第37回日本免疫学会総会・学術集会, 2007
プロテオーム解析を用いた白血病における血栓症発症に関与する蛋白質の探索, 第30回日本血栓止血学会学術集会, 2007
新規細胞内移行ペプチドの創出と血管機能制御技術としての展開, 第30回日本血栓止血学会学術集会, 2007
血管機能制御を目指した効率的な細胞内高分子導入技術の開発, 第30回日本血栓止血学会学術集会, 2007
TNF レセプター選択的阻害剤開発を目指した TNFR2-TNF 複合体 X 線結晶構造解析, 第30回日本血栓止血学会学術集会, 2007
血栓性疾患の機能解明・治療を目指したファージ抗体ライブラリの構築, 第30回日本血栓止血学会学術集会, 2007
血栓性疾患の機能解明・治療を目指した新規抗体単離システムの構築, 第30回日本血栓止血学会学術集会, 2007
新規抗体医薬の開発を目指した乳がん細胞特異マーカーの探索とそれらに対する網羅的抗体創製法の開発, 第57回日本薬学会近畿支部大会, 2007
細胞膜透過性 TAT ペプチドと膜融合性 HA2 ペプチドを活用した核内高分子送達法の開発, 第66回日本癌学会学術総会, 2007
A method for rapid preparation of antibodies to tumor-related proteins by the combination of phage library and 2D-DIGE, 第66回日本癌学会学術総会, 2007
三酸化ヒ素の抗白血病治療効果発現に関連した蛋白質の探索, 日本ヒトプロテオーム機構第5回大会, 2007
ファージ表面提示法を駆使した TNFR2 指向性アゴニストの創製, 日本ヒトプロテオーム機構第5回大会, 2007
腫瘍壊死因子－α の活性に及ぼす90番目のアミノ酸の影響に関する検討, 日本ヒトプロテオーム機構第5回大会, 2007
プロテオミクス創薬を志向した疾患関連蛋白質抗体の迅速単離システムの開発, 日本ヒトプロテオーム機構第5回大会, 2007
抗腫瘍活性に優れた TNF レセプター指向性変異体の創製, 第23回ＤＤＳ学会, 2007
全身投与による癌遺伝子治療の最適化を目指した高分子バイオコンジュゲート化アデノウイルスベクターの創製, 遺伝子・デリバリー研究会第7回シンポジウム, 2007
人工リンパ組織構築を目指したリジン欠損リンフォトキシン変異体創製に関する基礎的検討, 日本薬学会第127年会, 2007
抗腫瘍活性・リンパ組織形成能に優れた機能化 LIGHT 変異体創製に関する基礎的検討, 日本薬学会第127年会, 2007
カニクイザル遺伝子資源に対応する網羅的な抗体作製に向けた基礎検討, 日本薬学会第127年会, 2007
細胞内への薬物送達を志向したペプチドキャリアーの特性評価, 日本薬学会第127年会, 2007
ファージ抗体ライブラリを用いたイントラボディの効率的創製法の開発, 日本薬学会第127年会, 2007
TNFR1 特異的アンタゴニスト TNF;3-1C の X 線結晶構造解析, 日本薬学会第127年会, 2007
アンタゴニスト活性を有した TNF 変異体の創製に関する基礎的検討‐2, 日本薬学会第127年会, 2007
TNF レセプターの機能解析を目指した TNFR2 指向性変異体の作製, 日本薬学会第127年会, 2007
三酸化ヒ素刺激による酸化的修飾のプロテオーム解析, 日本薬学会第127年会, 2007
アンタゴニスト活性を有した TNF 変異体の創製に関する基礎的検討‐1, 日本薬学会第127年年会, 2007
TNFR1 指向性変異体を目指した新規ファージライブラリの作製, 日本薬学会第127年会, 2007
特異的結合能を有する構造変異体のスクリーニング条件の最適化, 日本薬学会第127年会, 2007
細胞内薬物療法の最適化を目指した細胞内移行性ペプチド(PTD)の特性評価, 日本薬学会第127年会, 2007
Transductional and transcriptional tumor-targeting using adenoviral vector with PEGylation and TERT promoter on systemic administration into tumor-bearing mice, AACR (American Association for Cancer Research) 97th Annual Meeting, 2006
疾患関連たんぱく質の探索とその有効活用技術の開発, 小野薬品工業特別講演会, 2006
新規抗 TNF 療法の開発を目指して, 第27回日本炎症・再生医学会, 2006
アンタゴニスト活性を有する TNF 変異体の創製と抗炎症治療薬への応用, ファーマ・バイオフォーラム2006, 2006
作用の点でのターゲティング能を付与した機能性人工蛋白質の創出, 第56回日本薬学会近畿支部総会・大会, 2006
ファージ抗体ライブラリを駆使した細胞内抗体（イントラボディ）の創製検討, 第2回創剤フォーラム若手発表討論会, 2006
細胞内薬物導入キャリアとしての細胞内移行性ぺプチド(PTD)の機能評価, 第2回創剤フォーラム若手発表討論会, 2006
Gene Shuffling ライブラリによる TNFR1 にターゲティング能を付与した構造変異体の創製, 第2回創剤フォーラム若手発表討論会, 2006
レセプターへのターゲティング能を付与したアンタゴニスト蛋白質の作製, 第2回創剤フォーラム若手発表討論会, 2006
ファージ抗体ライブラリを用いた疾患関連蛋白質抗体の迅速単離法の確立, 第4回JHUPO大会, 2006
構造―活性相関情報の迅速集積を目指したレセプター指向性構造変異体の作製, 第4回JHUPO大会, 2006
ファージ表面提示法を用いた構造変異生理活性蛋白質の創出, 第4回JHUPO大会, 2006
TNFR1 へターゲティング能を付与した構造変異 TNF-α の創製, 第22回日本ＤＤＳ学会学術集会, 2006
非免疫ファージ抗体ライブラリを用いた疾患関連蛋白質抗体の迅速単離法の確立, 第22回日本ＤＤＳ学会学術集会, 2006
腫瘍標的化を目指した改良型アデノウイルスベクターの創製, 日本薬剤学会第21年会, 2006
受容体への選択的ターゲティング能を有した機能性人工蛋白質の創出システムの開発, 日本薬学会第126年会, 2006
マウス T 細胞への遺伝子導入効率に優れるベクターシステムの探索, 日本薬学会第126年会, 2006
ポリエチレングリコール修飾アデノウイルスベクターを用いた腫瘍標的化自殺遺伝子治療の開発, 日本薬学会第126年会, 2006
アポトーシス抵抗性樹状細胞の創製と抗腫瘍ワクチン機能の評価, 日本薬学会第126年会, 2006
抗原提示細胞への抗原蛋白質デリバリーにおける γ-PGA ナノ粒子の有用性, 日本薬学会第126年会, 2006
抗原蛋白質を内包した γ-PGA ナノ粒子の特性評価と抗腫瘍ワクチンキャリアーへの応用, 日本薬学会第126年会, 2006
in vitro 抗体創製法としての改良型非免疫ファージライブラリの有用性評価, 日本薬学会第126年会, 2006
ファージ表面提示法を駆使した TNFR1 指向性変異体の作製‐3 : 構造変異 TNFα の精製たんぱく質の作製とその機能評価, 日本薬学会第126年会, 2006
ファージ表面提示法を駆使した TNFR1 指向性変異体の作製‐2 : パンニング条件の最適化と構造変異 TNFα のレセプター選択性の評価, 日本薬学会第126年会, 2006
ファージ表面提示法を駆使した TNFR1 指向性変異体の作製‐1 : TNF 構造変異体作製のためのファージライブラリの作製, 日本薬学会第126年会, 2006
細胞内薬物導入キャリアとしての細胞内移行性ペプチド（PTD）の機能評価, 日本薬学会第126年会, 2006
細胞内ターゲティング療法を目指した新規細胞内移行性ペプチドの創製, 日本薬学会第126年会, 2006
plll、pVlll 提示型ファージ表面提示法の特性評価, 日本薬学会第126年会, 2006
創薬を指向したプロテオミクス研究, 日本薬学会第126年会, 2006
高親和性抗体の迅速単離を目指した非免疫ファージ抗体ライブラリの構築, 日本薬学会第126年会, 2006
ファージ表面提示法を用いたリジン欠損 TNF-α の創出とその活性, 日本農芸化学会2006年度大会, 2006
Creation of useful mutant proteins using phage display technique for optimization of protein therapies, 2nd International Conference of Combinatorial Bioengineering (Human Life Science Forum), 2005
Modification of adenovirus vector with polyethylene glycol enhances accumulation and gene expression in tumor via intravenous injection, AACR (American Association for Cancer Research) 96th Annual Meeting, 2005
PEG 化たんぱく質の現状と今後, バイオロジクスフォーラム第3回学術集会, 2005
疾患関連たんぱく質の有効活用のための基盤技術開発, 第10回彩都バイオサイエンスセミナー, 2005
変異型抗アポトーシス蛋白質 Bcl-xFNK 発現樹状細胞を用いた抗腫瘍効果に関する検討, 第35回日本免疫学会総会・学術集会, 2005
IL-12 発現ベクターの腫瘍内投与による抗腫瘍効果と免疫系細胞の腫瘍内浸潤の向上, 第35回日本免疫学会総会・学術集会, 2005
両親媒化ポリ γ-グルタミン酸を用いた新規生分解性ナノキャリアの開発と抗腫瘍ワクチンへの応用‐1, 第35回日本免疫学会総会・学術集会, 2005
ファージ表面提示法を駆使した新規ペプチド性キャリアの構築, 第55回日本薬学会近畿支部総会・大会, 2005
ポリ γ-グルタミン酸を用いたガンワクチンキャリアの開発, 第9回日本ワクチン学会, 2005
Design of pH sensitive polymeric carrier for drug release and its application in cancer chemotherapy, 第78回日本生化学会大会, 2005
High-throughput Analytical Method for Finding Cytoplasm Transducing Peptides, 第78回日本生化学会大会, 2005
Functional evaluation of Protein Transduction Domains (PTDs) as intracellular drug delivery carriers, 第78回日本生化学会大会, 2005
Rapid identification of single-chain Fv (scFv) for various antigens using naive antibody library, 第78回日本生化学会大会, 2005
Creation of novel protein transduction domains (PTDs) using phage display system-based high-throughput screening methods, 第78回日本生化学会大会, 2005
Generation of cytospecific career peptides by fragment-peptides library derived from sindbis virus envelope protein, 第78回日本生化学会大会, 2005
Development of novel polymeric carriers for tissue specific protein delivery, 第78回日本生化学会大会, 2005
両親媒化ポリγ-グルタミン酸を用いた腫瘍ワクチンキャリアの開発, 第64回日本癌学会学術総会, 2005
腫瘍ターゲティングを目指したバイオコンジュゲート化アデノウイルスベクターの開発, 第64回日本癌学会学術総会, 2005
ポリビニルピロリドンを用いた機能性修飾高分子の開発に関する基礎検討, 第21回日本ＤＤＳ学会, 2005
pH 応答性薬物キャリアの開発とがん治療への応用, 第21回日本ＤＤＳ学会, 2005
ファージ表面提示法を駆使した新規ペプチド性キャリアの構築, 第21回日本ＤＤＳ学会, 2005
ナイーブ抗体ライブラリを用いた種々抗原に対する一本鎖抗体の迅速同定, 第21回日本ＤＤＳ学会, 2005
細胞内移行性ペプチド(PTD)による細胞内物質導入法に関する基礎的検討, 第21回日本ＤＤＳ学会, 2005
体内動態を制御できる修飾高分子の開発に向けた基礎検討, 第21回日本ＤＤＳ学会, 2005
細胞内トラフィック制御を指向した新規細胞内移行ペプチド(PTD)の開発とその評価, 第21回日本ＤＤＳ学会, 2005
シンドビスウイルス外殻蛋白質断片化ペプチドライブラリを駆使した神経細胞特異的キャリアペプチドの探索, 第21回日本ＤＤＳ学会, 2005
ワクチンキャリアとしてのポリアミノ酸由来生分解性ナノ粒子の有用性評価‐2, 第21回日本ＤＤＳ学会, 2005
ワクチンキャリアとしてのポリアミノ酸由来生分解性ナノ粒子の有用性評価‐1, 第21回日本ＤＤＳ学会, 2005
活性増強変異型抗アポトーシス蛋白質 Bcl-XFNK 発現樹状細胞を用いた腫瘍ワクチン療法, 第21回日本ＤＤＳ学会, 2005
IL-12 及び CCL27 発現アデノウイルスベクターの併用投与による抗腫瘍効果とその有用性評価, 第21回日本ＤＤＳ学会, 2005
IL-12 発現アデノウイルスベクターの腫瘍内投与による抗腫瘍効果と免疫細胞の腫瘍内浸潤, 第21回日本ＤＤＳ学会, 2005
IL-12 及び CCL27 発現アデノウイルスベクターの併用投与による抗腫瘍効果増強機構の解明, 第21回日本ＤＤＳ学会, 2005
ポリエチレングリコール修飾アデノウイルスベクターの EPR 効果に関する検討, 第21回日本ＤＤＳ学会, 2005
Modification of adenovirus vector with polyethylene glycol enhances accumulation and gene expression in tumor via intravenous injection, 第96回米国癌学会, 2005
機能性人工蛋白質の創製と疾病治療への応用, 日本薬学会第125年会, 2005
変異型 Bcl-XL(FNK) 遺伝子導入樹状細胞を用いた腫瘍ワクチン療法の最適化－2, 日本薬学会第125年会, 2005
蛋白質断片化ペプチドライブラリを利用した蛋白質機能ドメインの新規探索システムの構築―その1, 日本薬学会第125年会, 2005
次世代ターゲティング療法を目指した新規細胞内移行ペプチドの創製, 日本薬学会第125年会, 2005
細胞内薬物導入キャリアとしての細胞内移行ペプチドの特性評価, 日本薬学会第125年会, 2005
IL-12 と CCL27 の併用による抗腫瘍効果増強機構の解明, 日本薬学会第125年会, 2005
変異型 Bcl-XL(FNK) 遺伝子導入樹状細胞を用いた腫瘍ワクチン療法の最適化－1, 日本薬学会第125年会, 2005
Polyethylene Glycol 修飾アデノウイルスベクターの腫瘍集積性に関する検討, 日本薬学会第125年会, 2005
IL-12 発現アデノウイルスベクターを用いた IL-12 非奏功性腫瘍に対する治療効果に関する検討, 日本薬学会第125年会, 2005
ファージ表面提示法を駆使した新規細胞内移行ペプチドの網羅的創出システムの確立, 日本薬学会第125年会, 2005
蛋白質断片化ペプチドライブラリを利用した蛋白質機能ドメインの新規探索システムの構築―その2, 日本薬学会第125年会, 2005
Claudin-4 指向性分子の創製, 日本薬学会第125年会, 2005
体内動態制御を目指したポリエチレングリコール修飾アデノウイルスベクターの腫瘍集積性に関する検討, 日本薬剤学会第20年会, 2005
PEGylated adenovirus vectors containing RGD peptides show high transduction efficiency and protection ability from neutralizing antibodies, PSWC, 2004
Enhanced gene expression of adenovirus vector in tumor induced by the PEGylation, PSWC, 2004
Efficient delivery of encapsulated molecule to antigen presenting cells by Fusogenic-Liposome, PSWC, 2004
生理活性蛋白質の体内挙動を時空間的に制御できる高分子バイオコンジュゲーション法の確立, 製剤セミナー, 2004
IL-12 及び CCL27 発現アデノウイルスベクターの併用投与による抗腫瘍効果と免疫系細胞の浸潤, 第34回日本免疫学会総会・学術集会, 2004
サイトカインの新規バイオコンジュゲーション法の開発とその有用性評価, 第34回日本免疫学会総会・学術集会, 2004
癌免疫療法の最適化を目指した機能性サイトカインの創出システムの開発とその評価, 第34回日本免疫学会総会・学術集会, 2004
医薬価値に優れた機能性人工 TNF-α の創製とその疾病治療への展開, 第34回日本免疫学会総会・学術集会, 2004
ファージ抗体ライブラリによる抗原特異的モノクロナール抗体の網羅的な迅速単離, 第34回日本免疫学会総会・学術集会, 2004
サイトカイン療法の最適化を目指した新規部位特異的バイオコンジュゲーション法の開発とその評価, 第34回日本免疫学会総会・学術集会, 2004
抗体療法の最適化を目指したリジン欠損一本鎖抗体の創製, 第34回日本免疫学会総会・学術集会, 2004
ファージ表面提示法を利用したウイルス感染を担うペプチド探索法の構築, 第34回日本免疫学会総会・学術集会, 2004
細胞内薬物導入キャリアとしての細胞内移行ペプチドの特性評価, 第34回日本免疫学会総会・学術集会, 2004
Cell Delivery System に基づく癌免疫療法の最適化, 第54回日本薬学会近畿支部総会・大会, 2004
抗腫瘍免疫細胞の体内動態を制御する Cell Delivery System による癌免疫療法の最適化, 第3回ファーマ・バイオフォーラム2004, 2004
細胞内薬物導入キャリアとしての細胞内移行ペプチドの特性評価に関する基礎的検討, 第20回ＤＤＳ学会, 2004
新規腎ターゲティングキャリアの開発と腎不全に対する蛋白療法の最適化, 第20回ＤＤＳ学会, 2004
ファージ表面提示法を利用した新規細胞内移行ペプチドの網羅的探索システムの構築, 第20回ＤＤＳ学会, 2004
ファージ表面提示法を駆使した部位特異的バイオコンジュゲーションの最適化, 第20回ＤＤＳ学会, 2004
プロテオーム創薬にかなう機能性人工蛋白質の迅速創出とそのバイオコンジュゲーションへの展開, 第20回ＤＤＳ学会, 2004
体内動態制御を目指したポリエチレングリコール修飾アデノウイルスベクターの in vivo 遺伝子発現特性に関する検討, 第20回ＤＤＳ学会, 2004
PEGylation of adenovirus vector enhances gene expression in tumor via systemic administration, 第10回日本遺伝子治療学会, 2004
Enhanced gene expression of adenovirus vector in tumor induced by the PEGｙlation., 第2回世界薬学会議, 2004
PEGylated adenovirus vectors containing RGD peptides show high transduction efficiency and protection ability from neutralizing antibodies, 第2回世界薬学会議（PSWC）, 2004
Efficient delivery of encapsulated molecule to antigen presenting cells by Fusogenic-Liposome, 第2回世界薬学会議（PSWC）, 2004
体内動態制御を目指したバイオコンジュゲート化アデノウイルスベクターの創製, 遺伝子デリバリー研究会第4回シンポジウム, 2004
Cell Delivery System による癌遺伝子治療の最適化, 遺伝子デリバリー研究会第4回シンポジウム, 2004
プロテオーム創薬に叶う DDS 基盤技術の開発, 日本薬学会第124年会, 2004
抗体療法の最適化を目指した創薬基盤テクノロジーの開発, 日本薬学会第124年会, 2004
細胞内移行ペプチドを利用した細胞内薬物送達に関する基礎的検討, 日本薬学会第124年会, 2004
新規腎ターゲティングキャリアーの腎疾患治療への応用, 日本薬学会第124年会, 2004
医薬価値に優れた新規機能性ペプチドの網羅的探索システムの構築, 日本薬学会第124年会, 2004
蛋白療法の最適化に向けた腎ターゲティングキャリアの開発, 日本薬学会第124年会, 2004
Synergistic anti-tumor activity induced by the combination of adenovirus vectors encoding cytokine and chemokine, 日本薬学会第124年会, 2004
ポリエチレングリコール修飾アデノウイルスベクターの体内動態に関する検討, 日本薬学会第124年会, 2004
膜融合リポソームによるHTLV-Ⅰペプチドワクチンの開発, 日本薬学会第124年会, 2004
膜融合リポソーム（FL）内封ナノ粒子の生体内動態解析, 日本薬学会第124年会, 2004
医薬価値に優れた機能性人工蛋白質の創製とDDSへの展開, 創剤フォーラム第9回若手研究会, 2003
Creation of lysine-deficient proteins with full bioactivities results in a novel PEGylation system, 第76回日本生化学会大会, 2003
薬物の時空間的な体内挙動を制御できる高分子バイオコンジュゲーション法, 第5回地域交流フォーラム, 2003
プロテオーム創薬のためのDDS基盤技術の開発, 武田製剤研セミナー, 2003
ポストゲノム戦略に叶う機能性人工蛋白質の迅速創出とそのPEGylationへの展開, 第4回地域交流フォーラム, 2003
医薬価値に優れた機能性変異蛋白質の網羅的創製とそのDDSへの応用, 第53回日本薬学会近畿支部総会・大会, 2003
医薬価値に優れた機能性人工蛋白質を迅速創製可能な創薬戦略の確立に向けて, 第62回日本癌学会総会, 2003
抗 TNF 療法の最適化に向けた1本鎖抗体の部位特異的バイオコンジュゲーションに関する基礎的検討, 第19回日本ＤＤＳ学会, 2003
癌ミサイル療法の最適化に向けた Immunotoxin の部位特異的バイオコンジュゲーションに関する検討, 第19回日本ＤＤＳ学会, 2003
目的とする生理活性を完全に保持した機能性変異蛋白質の迅速構築とそのDDSへの応用, 日本薬剤学会第18年会, 2003
抗 TNF-alpha 療法の最適化に向けて： TNF-alpha に対する1本鎖抗体の作成とその特性評価, 日本薬学会第123年会, 2003
ファージ表面提示法を駆使した部位特異的バイオコンジュゲーションの最適化, 日本薬学会第123年会, 2003
医薬価値に優れた機能性人工蛋白質の設計戦略の確立に向けて‐2, 日本薬学会第123年会, 2003
医薬価値に優れた機能性人工蛋白質の設計戦略の確立に向けて-1, 日本薬学会第123年会, 2003
Tumor vascular targeting therapy using tumor-endothelium specific monoclonal antibody (TES-23), FIRST INTERNATIONAL CONFERENCE ON VASCULAR TARGETING, 2002
Construction and evaluation of phage-displayed naive antibody libraries derived from human, mouse and rabbit, 29th Annual Meeting of the Controlled Release Society, 2002
Elucidation of immune enhancing mechanisms for the induction of antigen specific immune response by fusogenic liposome as a new mucosal vaccine carrier, 第32回日本免疫学会総会・学術集会, 2002
目的とする生理活性を完全に保持したリジン欠損機能性蛋白質の迅速構築とそのDDSへの応用, ファーマ・バイオフォーラム2002, 2002
遺伝子治療の最適化を目指したアデノウイルスベクターのpolyethylene Glycol 修飾と遺伝子発現活性, 第18回日本ＤＤＳ学会, 2002
g8p 提示型ファージペプチドライブラリの構築及び機能評価, 第18回日本ＤＤＳ学会, 2002
ファージ抗体ライブラリによるモノクローナル抗体の網羅的迅速単離とその抗体療法の最適化に関する基礎的検討, 第18回日本ＤＤＳ学会, 2002
ファージディスプレイシステムを用いた有効な生理活性蛋白質の創出, 第18回日本ＤＤＳ学会, 2002
部位特異的バイオコンジュゲーション・システムの構築～リジン欠損 TNF-α 変異体の作製とその評価～, 第60回日本癌学会, 2002
癌抗原 WT1 標的癌ワクチン療法に向けた抗原デリバリーデバイス, 日本薬剤学会第17年会, 2002
小胞体挿入配列を含むモデル癌抗原を用いた抗癌免疫誘導, 日本薬学会第122年会, 2002
PPARg 発現アデノウイルスベクターによる炎症性腸疾患治療法の開発, 日本薬学会第122年会, 2002
Polyethylene Glycol を用いたバイオコンジュゲート化アデノウイルスベクターの粒子設計, 日本薬学会第122年会, 2002
アデノウイルスファイバー領域を提示したファージの構築とそのペプチドライブラリ化, 日本薬学会第122年会, 2002
特定組織移行・再構築細胞の検索～神経幹細胞の生存と分化～, 日本薬学会第122年会, 2002
Phage display system を利用した部位特異的バイオコンジュゲーション法の開発, 日本薬学会第122年会, 2002
機能性ペプチドの網羅的検索・同定を目的としたファージ表面ランダムペプチド提示ライブラリの構築, 日本薬学会第122年会, 2002
ナイーブ一本鎖抗体提示 phage library の構築および特異的抗体単離に関する検討 (その2) ～特異的抗体に関する検討～, 日本薬学会第122年会, 2002
ナイーブ一本鎖抗体提示 phage library の構築および特異的抗体単離に関する検討 (その1) ～phage library の作製～, 日本薬学会第122年会, 2002
Development of a novel functional polymeric modifier with control releaseand renal targeting capacity, International Symposium on Polymer Therapeutics, 2001
リコンビナント･イムノトキシンの改良による癌ミサイル療法の最適化とファージ表面提示法の薬学的展開, 生物薬剤学セミナー・創剤フォーラム特別講演会, 2001
膜融合リポソーム (FL) と小胞体挿入配列を用いた MHC class I 提示経路への効率的抗原送達, 第31回日本免疫学会, 2001
抗原キャリアーとしての膜融合リポソームを用いた際の抗原特異的 CTL 誘導機構, 第5回日本ワクチン学会, 2001
細胞性製剤への抗補体作用付与による液性免疫隔離に関する基礎的検討, 第17回日本ＤＤＳ学会, 2001
膜融合リポソームによるヘルパーT細胞の活性化とその封入抗原特異的 CTL 誘導への影響, 第17回日本ＤＤＳ学会, 2001
上皮細胞に対するセンダイウイルス並びに膜融合リポソームのMHC class Ⅱ分子発現増強メカニズムに関する検討, 第17回日本ＤＤＳ学会, 2001
薬物治療の最適化を充たす次世代バイオコンジュゲートDDSの確立に向けて, 第17回日本ＤＤＳ学会, 2001
ファイバーミュータントアデノウイルスベクターにより抗原遺伝子導入した樹状細胞の免疫学的機能評価, 第17回日本ＤＤＳ学会, 2001
細胞接着ペプチドの高分子化 DDS とその癌転移抑制能の評価, 日本薬学会第121年会, 2001
体液性免疫隔離能を付与した細胞性製剤の開発, 日本薬学会第121年会, 2001
血管内皮細胞を腫瘍への薬物キャリアとして用いるための基本的検討, 日本薬学会第121年会, 2001
腎指向性修飾高分子の特性評価 ―バイオコンジュゲート化 DDS への応用に向けて―, 日本薬学会第121年会, 2001
腎指向性修飾高分子の特性評価, 日本薬剤学会第16年会, 2001
液性免疫隔離能を有する細胞性製剤の設計, 日本薬剤学会第16年会, 2001
the controlled release of drugs into cytoplasm from nanospheres introduced in the cell by fusogenic liposomes, Millennial World Congress of Pharmaceutical Sciences(FIP), 2000
Development of the novel cytomedical device that can protect against hostユs humoral immunity, Millennial World Congress of Pharmaceutical Sciences(FIP), 2000
Cytomedical therapy for diabetes mellitus using microencapsulated pancreatic beta cell line with glucose sensor, Millennial World Congress of Pharmaceutical Sciences(FIP), 2000
Novel Fusogenic Liposome Induce MHC Class II Mediated Helper T cell and Humoral Immune Responses at Mucosal and Systemic Site, Millennial World Congress of Pharmaceutical Sciences(FIP), 2000
Development of a novel method for the bioconjugation of cytokines using a reversible amino-protective reagent, Millennial World Congress of Pharmaceutical Sciences(FIP), 2000
DNA デリバリーを応用した経口コレラワクチンの設計, 日本薬学会第120回年会, 2000
細胞性製剤の体液性免疫隔離 (2) ～補体失活能を有する新規細胞固定化担体の開発～, 日本薬学会第120回年会, 2000
細胞性製剤の体液性免疫隔離 (1) ～細胞固定化担体の補体透過性抑制効果～, 日本薬学会第120回年会, 2000
腎指向性修飾高分子の開発とその特性評価, 日本薬学会第120回年会, 2000
腫瘍血管に対する Targeting 能を付与した血管内皮細胞の基礎的検討, 日本薬学会第120回年会, 2000
膜融合リポソームの癌遺伝子免疫療法への応用, 日本薬学会第120回年会, 2000
Novel Fusogenic Liposome Induce MHC class II mediated Mucosal and Systemic Helper Tcell Responses, 第29回日本免疫学会総会, 1999
新規経粘膜ワクチンキャリアーとしての膜融合リポソームの有用性評価および免疫誘導機序に関する基礎的検討, 第49回日本薬学会近畿支部総会, 1999
新規修飾制御法による PEG 化 IL-6 の血小板増加作用増強効果, 第58回日本癌学会総会, 1999
DNA ワクチンベクターとしての膜融合リポソームの有用性評価, 第15回日本ＤＤＳ学会, 1999
腎指向性修飾高分子の腎臓内挙動特性, 第15回日本ＤＤＳ学会, 1999
細胞内徐放による細胞質内遺伝子発現コントロールシステムの開発, 第15回日本ＤＤＳ学会, 1999
癌ワクチン用アジュバントとして Lipofectin を用いた際の抗癌ワクチン効果, 第15回日本ＤＤＳ学会, 1999
新規粘膜ワクチンキャリアーの開発：膜融合リポソームによる粘膜免疫の誘導, 第15回日本ＤＤＳ学会, 1999
mRNA を利用した新規細胞室内遺伝子発現系の確立, 日本薬学会第119回年会, 1999
培養癌組織血管内皮細胞を用いた癌組織血管の特性評価, 日本薬学会第119回年会, 1999
異種補体抵抗性を有する細胞性製剤の開発に関する基礎的検討～補体失活作用を付与した新規高分子担体の設計～, 日本薬学会第119回年会, 1999
MIN6 細胞を封入した細胞性製剤の糖尿病モデルラットへの適用～細胞性製剤に対する異種動物免疫系の影響～, 日本薬学会第119回年会, 1999
全身系免疫誘導能を指標にした膜融合リポソームの粘膜ワクチンキャリアーとしての有用性評価, 日本薬学会第119回年会, 1999
膜融合リポソームの DNA ワクチンベクターとしての基礎的検討, 日本薬学会第119回年会, 1999
バイオコンジュゲーションによる細胞接着ペプチドの癌転移抑制効果の増強, 日本薬学会第119回年会, 1999
新規修飾制御法を用いたバイオコンジュゲート化サイトカインの開発とその評価, 日本薬学会第119回年会, 1999
トランスポーターによるカルボン酸系薬物の皮膚内動態制御に関する基礎的検討, 日本薬剤学会第14年会, 1999
膜融合リポソームの細胞質内直接物質導入機構に関する基礎的検討, 日本薬剤学会第14年会, 1999
抗原含有粘膜付着性マイクロマトリックスの製剤特性評価および粘膜ワクチンキャリアーへの応用, 日本薬剤学会第14年会, 1999
β-globin sequence の付加にともなうT7細胞質内遺伝子発現系の改善, 日本薬剤学会第14年会, 1999
Bioconjugation による薬物治療の最適化, 中外分子医学研究所セミナー, 1998
癌ワクチン用アジュバントとしてのLipofectin～その抗原提示促進作用と in vivo におけるアジュバント効果～, 第28回日本免疫学会, 1998
膜融合リポソームによる外来性抗原のMHC class I 抗原提示促進作用およびCTL誘導能の評価, 第28回日本免疫学会, 1998
体液性免疫誘導能を指標にした膜融合リポソームの粘膜ワクチンキャリアーとしての機能評価, 第28回日本免疫学会, 1998
水溶性高分子 Bioconjugation による癌治療の最適化, 第48回日本薬学会近畿支部総会･大会, 1998
癌組織血管内皮細胞を標的とした新規癌ミサイル療法の開発, 第48回日本薬学会近畿支部総会･, 1998
細胞性製剤の長期機能性維持に関する基礎的検討, 第48回日本薬学会近畿支部総会･大会, 1998
外来性抗原のMHC class I 抗原提示を指向したDDSによる効果的な抗原特異的免疫反応誘導, 第48回日本薬学会近畿支部総会･大会, 1998
水溶性高分子 Bioconjugation による生理活性蛋白質の分子レベルでのDDS戦略, 第14回日本ＤＤＳ学会, 1998
正常ヒト表皮角化細胞におけるモノカルボン酸系薬物の担体介在型輸送, 第14回日本ＤＤＳ学会, 1998
抗原含有粘膜付着性マイクロマトリックスの各種要因による溶出性変化, 第14回日本ＤＤＳ学会, 1998
高分子バイオコンジュゲーションによる生理活性蛋白質のDDS ；新規修飾制御法を用いた高活性TNF-αの開発とその評価, 第14回日本ＤＤＳ学会, 1998
生理活性ペプチドの高分子ハイブリッド化DDS ；ポリスチレンマレイン酸共重合体によるラミニン関連細胞接着ペプチドのバイオコンジュゲーションとその癌転移抑制効果, 第14回日本ＤＤＳ学会, 1998
膜融合リポソームを用いた細胞質内遺伝子発現系の確立, 第14回日本ＤＤＳ学会, 1998
遺伝子発現効率増強を目指した膜融合リポソームの改良, 第14回日本ＤＤＳ学会, 1998
液性免疫隔離能を付与した新規細胞固定化担体の開発に関する基礎的検討, 第14回日本ＤＤＳ学会, 1998
機能性高分子によるバイオコンジュゲート医薬品の創製： DIVEMA-TNF-αの作用分離特性評価, 第14回日本ＤＤＳ学会, 1998
腎 targeting carrier の開発とその評価, 第14回日本ＤＤＳ学会, 1998
癌組織血管内皮細胞を標的としたミサイル療法の開発, 第2回がん分子標的治療研究会総会, 1998
アミノ酸型PEG誘導体によるラミニン関連ペプチドのハイブリッド化, 日本薬学会第118年会, 1998
pH応答性修飾高分子のハイブリッド化DDSの確立, 日本薬学会第118年会, 1998
プラスミドベクターが及ぼすDNAワクチンの免疫誘導能への影響, 日本薬学会第118年会, 1998
水溶性高分子によるハイブリッド化医薬品の創製：水溶性高分子の生体内挙動特性と親水疎水バランス，電荷の連関評価, 日本薬学会第118年会, 1998
リポソームの陽電荷密度上昇による腫瘍ワクチンアジュバント効果増強, 日本薬学会第118年会, 1998
水溶性高分子の動態特性評価に基づいたバイオコンジュゲート医薬品の分子設計理論の構築, 日本薬剤学会第13年会, 1998
抗原分子の生体内および細胞内動態制御による効果的な免疫反応の誘導～膜融合リポソームの抗原提示促進作用とアジュバント効果～, 日本薬剤学会第13年会, 1998
Preparation of a poly(ethylene glycol) hybrid containing two active fragments of laminin, International Peptide symposium, 1997
Bioconjugationによるサイトカイン療法の最適化, 第56回日本癌学会総会, 1997
Bioconjugationによる薬物治療の最適化, 山之内製薬･研究セミナー, 1997
Bioconjugationによる薬物治療の最適化, 第34回薬剤学懇談会研究討論会, 1997
Bioconjugationによる薬物治療の最適化を目指して, 昭和薬科大学助手会セミナー, 1997
ワクチンベクターとしてのLipofectinによる抗原提示促進作用とin vivoにおけるアジュバント効果, 第12回日本薬物動態学会年会, 1997
腫瘍ワクチンアジュバントとしてのリポソームの粒子設計：カオチン化によるリポソームアジュバントの効果増強, 第27回日本免疫学会総会･学術集会, 1997
DIVEMAハイブリッドTNF-αの分子設計とその抗腫瘍効果, 第56回日本癌学会総会, 1997
癌組織血管内皮細胞に対するモノクローナル抗体を用いたミサイル療法の確立とその評価, 第56回日本癌学会総会, 1997
腫瘍支配動脈内へのTumor Necrosis Factor-α(TNF)の持続供給によって誘導される抗腫瘍免疫機構の解明, 第56回日本癌学会総会, 1997
腫瘍ワクチンアジュバントとしてのリポソームの粒子設計－カチオン化によるリポソームアジュバントの効果－, 第56回日本癌学会総会, 1997
水溶性高分子Bioconjugationによる癌治療の最適化, 第47回日本薬学会近畿支部総会, 1997
膜融合リポソームによる外来性抗原のMHC classl分子を介する抗原提示, 第13回日本ＤＤＳ学会, 1997
膜融合リポソームによる体液性免疫誘導増強, 第13回日本ＤＤＳ学会, 1997
水溶性高分子によるハイブリッド化医薬品の創製：水溶性高分子の生体内挙動特性と荷電官能基の連関評価, 第13回日本ＤＤＳ学会, 1997
VSVを利用した新規遺伝子導入ベクターの開発に関する基礎的検討, 第13回日本ＤＤＳ学会, 1997
腫瘍ワクチンアジュバントとしてのリポソームの粒子設計－陽電荷密度上昇によるリポソームアジュバントの効果増強－, 第13回日本ＤＤＳ学会, 1997
Bioconjugationによるサイトカイン療法の最適化, 第1回がん分子標的治療研究会総会, 1997
水溶性高分子ハイブリッド化による薬物治療の最適化：水溶性高分子の生体内挙動特性, 第46回日本高分子学会年次大会, 1997
サイトカインの多様なin vivo生理作用の中から目的とする治療作用と副作用を分離しうるBioconjugationの確立とサイトカイン療法の最適化, 日本薬剤学会第12年会, 1997
機能性修飾高分子によるインテリジェント化生理活性蛋白質の分子設計： DIVEMAハイブリッド化TNF-αの創製とその評価, 日本薬学会第117年会, 1997
pH応答性修飾高分子の開発とハイブリッド化DDSへの応用, 日本薬学会第117年会, 1997
アミノ酸型PEG誘導体によるファイブロネクチン関連ペプチドのハイブリッド化, 日本薬学会第117年会, 1997
抗腫瘍血管内皮細胞モノクローナル抗体によるIn Vivo抗体依存性殺細胞効果, 日本薬学会第117年会, 1997
腫瘍組織血管内皮細胞を認識するモノクローナル抗体 TES-23 の各種腫瘍組織血管に対する反応性の検討, 日本薬学会第117年会, 1997
腫瘍支配動脈へのTumor Necrosis Factor (TNF) 遺伝子導入による抗腫瘍効果誘導メカニズム, 日本薬学会第117年会, 1997
遺伝子導入ベクターとしての最適な膜融合リポソームの粒子設計, 日本薬学会第117年会, 1997
Cationic liposomeを腫瘍ワクチンベクターとして用いた抗腫瘍免疫の誘導増強, 日本薬学会第117年会, 1997
カチオン化によるリポソームアジュバントの抗腫瘍ワクチン効果増強, 日本薬学会第117年会, 1997
水溶性高分子ハイブリッド化医薬品の分子設計（2）：各種水溶性高分子の生体内挙動, 日本薬学会第117年会, 1997
Optimaization of drug therapy based on molecular design of hybrid bioactive proteins with water-soluble polymers, International MRS symposium, 1996
Molecular design of hybrid cytokines with water-soluble polymers, 23rd International Symposium on Controlled Release of Bioactive Materials, 1996
Lecithinization of IL-6 enhances its thrombopoietic activity in mice, 23rd International Symposium on Controlled Release of Bioactive Materials, 1996
水溶性高分子ハイブリッド化サイトカインの分子設計とその評価, 酵素工学研究会第35回講演会, 1996
ハイブリッド化サイトカインの分子設計と薬物治療の最適化, 第5回新適塾『21世紀の薬箱』, 1996
RGBとポリ（オキシエチレン）ジプロピルアミンとのハイブリッドの合成とその抗転移効果, 第46回日本薬学会近畿支部総会・大会, 1996
ファイブロネクチン関連ペプチドのPEGハイブリッド合成, 第34回ペプチド化学討論会, 1996
ラット腫瘍血管内皮細胞に対するモノクローナル抗体の作製とその抗腫瘍効果, 第55回日本癌学会総会, 1996
腫瘍組織血管内皮細胞に対するモノクローナル抗体を用いた新しい癌ミサイル療法の開発, 第55回日本癌学会総会, 1996
DIVEMAによるハイブリッド化TNF-αの創製とその評価, 第9回日本生化学会大会・第19回日本分子生物学会年会合同年会, 1996
水溶性高分子ハイブリッドTNFの作製とその抗腫瘍効果, 第9回日本生化学会大会・第19回日本分子生物学会年会合同年会, 1996
ハイブリッド化IL-6の創製と血小板増加作用増強効果, 第9回日本生化学会大会・第19回日本分子生物学会年会合同年会, 1996
Development of novel delivery system for bioactive molecules using immobilized cells, 第12回日本ＤＤＳ学会, 1996
細胞接着ペプチド及びそのSMAハイブリッド体の癌転移抑制効果, 第5回がん転移研究会総会, 1996
腫瘍組織血管内皮細胞に対するモノクローナル抗体を用いたTargeting療法の開発, 日本薬学会第116年会, 1996
腫瘍組織血管内皮細胞に対する特異抗体の作製とその評価, 日本薬学会第116年会, 1996
多機能性ハイブリッド化生理活性物質の分子設計：造血サイトカインのPVPハイブリッド化, 日本薬学会第116年会, 1996
水溶性高分子ハイブリッド化医薬品の分子設計：修飾高分子の体内挙動に及ぼす親水－疎水バランスの影響, 日本薬学会第116年会, 1996
細胞封入アルギン酸－ポリリジン－アルギン酸マイクロカプセルを用いた細胞製剤開発の基礎的検討, 日本薬学会第116年会, 1996
ラミニン関連ペプチドの合成と癌転移抑制作用, 日本薬学会第116年会, 1996
生理活性タンパク質の水溶性高分子ハイブリッド化とその評価, 第13回生物薬剤学研究会, 1995
腫瘍組織血管内皮細胞の物質透過機構に関する基礎的検討, 第10回日本薬物動態学会年会, 1995
ラミニン関連ペプチドの合成と癌転移抑制作用, 第33回ペプチド化学討論会, 1995
多機能性ハイブリッド生理活性蛋白質の分子設計： PVP ハイブリッドTNF-αのin vivo抗腫瘍効果およびその体内動態, 第11回日本ＤＤＳ学会, 1995
ラミニンおよびフィブロネクチン関連ペプチドの合成と腫瘍細胞転移抑制作用, 日本薬学会第115年会, 1995
アガロースゲル包括固定化抗IL-6抗体産生細胞を用いたIL-6トランスジェニックマウスの病態改善, 日本薬学会第115年会, 1995
多機能性ハイブリッド生理活性蛋白質の分子設計： PVPハイブリッドTNF-αの創製とその評価, 日本薬学会第115年会, 1995
Molecular Design of Hybrid TNF-α with PEG Increases its Anti-Tumor Potency, 7th US-Japana symposium of Biopharmaceutics, 1994
水溶性高分子ハイブリッドTNF-αの分子設計：最適のハイブリッド化条件の追求, 第9回日本薬物動態学会年会, 1994
TNF-α低感受性腫瘍に対するPEGハイブリッド化TNF-αの抗腫瘍効果, 第53回日本癌学会総会, 1994
ハイブリッド化インターロイキン6の創製とその造血作用増強効果, 第10回日本ＤＤＳ学会, 1994
PEGハイブリッド化TNF-αの体内挙動の検討, 第8回日本薬物動態学会年会, 1993
アガロース細胞包埋法を用いた新規In Vivo血管新生評価系の開発, 第52回日本癌学会総会, 1993
PEG修飾によるハイブリッドTNF-αの分子設計およびIn Vivo抗腫瘍効果の増強, 第52回日本癌学会総会, 1993
PEGハイブリッド化によるTNF-αの抗腫瘍効果の増強, 第2回ＤＤＳカンファランス, 1993
ハイブリッドTNF-αの創製： PEG修飾によるIn Vivo抗腫瘍効果の増強, 日本薬学会第113年会, 1993
ヒト血管内皮細胞のIn Vitro血管新生能に及ぼす細胞外マトリックスの影響, 日本薬学会第112年会, 1992
ハイブリッド薬物の分子設計の基礎：水溶性高分子と血管内皮細胞の相互作用, 日本薬学会第112年会, 1992
細胞内Ca2＋動態を指標とした水溶性高分子と血管内皮細胞の相互作用の検討, 第21回医用高分子シンポジウム, 1992
アクリルアミドによるSODの高分子化, 第21回医用高分子シンポジウム, 1992
Co-Cultureによる培養血管内皮細胞の物質透過性への影響, 日本薬学会第111年会, 1991
血管内皮細胞のIn Vitro管形成に及ぼすラミニン関連ペプチドの影響, 日本薬学会第111年会, 1991

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