新技術が変える内科診療 患者検体シングルセル解析に基づいた膠原病疾患多様性の理解

西出 真之, 熊ノ郷 淳

日本内科学会雑誌　Vol. 113　No. 9　p. 1594-1601　2024/09

【ヒト疾患と免疫細胞サブセット 解像度をあげて見えてきた病態を規定する疾患のキープレーヤーと治療戦略】(第4章)疾患とのかかわり ANCA関連血管炎に特徴的な単球細胞集団の発見

西出 真之, 熊ノ郷 淳

実験医学　Vol. 42　No. 12　p. 1951-1956　2024/08

Single-cell analysis reveals immune cell abnormalities underlying the clinical heterogeneity of systemic sclerosis

Masayuki Nishide, Hiroshi Shimagami, Kei Nishimura, Hiroaki Matsushita, Shoichi Metsugi, Yasuhiro Kato, Takahiro Kawasaki, Kohei Tsujimoto, Ryuya Edahiro, Eri Itotagawa, Maiko Naito, Shoji Kawada, Daisuke Nakatsubo, Kazuki Matsukawa, Tomoko Namba-Hamano, Kazunori Inoue, Atsushi Takahashi, Masayuki Mizui, Ryusuke Omiya, Yoshitaka Isaka, Yukinori Okada, Kunihiro Hattori, Masashi Narazaki, Atsushi Kumanogoh

2024/07/22

Semaphorin 6D tunes amygdalar circuits for emotional, metabolic, and inflammatory outputs

Yoshimitsu Nakanishi, Mayuko Izumi, Hiroaki Matsushita, Yoshihisa Koyama, Diego Diez, Hyota Takamatsu, Shohei Koyama, Masayuki Nishide, Maiko Naito, Yumiko Mizuno, Yuta Yamaguchi, Tomoki Mae, Yu Noda, Kamon Nakaya, Satoshi Nojima, Fuminori Sugihara, Daisuke Okuzaki, Masahito Ikawa, Shoichi Shimada, Sujin Kang, Atsushi Kumanogoh

Neuron　2024/07　Research paper (scientific journal)

Neutrophil single-cell analysis identifies a uniquely primed subset and provides insights into predicting relapse of autoimmune small vessel vasculitis

Masayuki Nishide, Kei Nishimura, Hiroaki Matsushita, Shoji Kawada, Hiroshi Shimagami, Shoichi Metsugi, Yasuhiro Kato, Takahiro Kawasaki, Kohei Tsujimoto, Ryuya Edahiro, Yuya Shirai, Eri Itotagawa, Maiko Naito, Yuji Yamamoto, Kazuki Matsukawa, Ryusuke Omiya, Yukinori Okada, Kunihiro Hattori, Masashi Narazaki, Atushi Kumanogoh

2024/06/28

Galectin-10 in serum extracellular vesicles reflects asthma pathophysiology.

Hanako Yoshimura, Yoshito Takeda, Yuya Shirai, Makoto Yamamoto, Daisuke Nakatsubo, Saori Amiya, Takatoshi Enomoto, Reina Hara, Yuichi Adachi, Ryuya Edahiro, Moto Yaga, Kentaro Masuhiro, Taro Koba, Miho Itoh-Takahashi, Mana Nakayama, So Takata, Yuki Hosono, Sho Obata, Masayuki Nishide, Akinori Hata, Masahiro Yanagawa, Satoko Namba, Michio Iwata, Momoko Hamano, Haruhiko Hirata, Shohei Koyama, Kota Iwahori, Izumi Nagatomo, Yasuhiko Suga, Kotaro Miyake, Takayuki Shiroyama, Kiyoharu Fukushima, Shinji Futami, Yujiro Naito, Takahiro Kawasaki, Kenji Mizuguchi, Yusuke Kawashima, Yoshihiro Yamanishi, Jun Adachi, Mari Nogami-Itoh, Shigeharu Ueki, Atsushi Kumanogoh

The Journal of allergy and clinical immunology　2024/03/14　Research paper (scientific journal)

全身性強皮症におけるレイノー現象対策の薬剤費の調査結果

嶋 良仁, 渡邉 あかね, 水野 裕美子, 泉 真祐子, 辻本 考平, 糸田川 英里, 西出 真之, 加藤 保宏, 楢崎 雅司, 熊ノ郷 淳

日本リウマチ学会総会・学術集会プログラム・抄録集　Vol. 68回　p. 750-750　2024/03

Sema6D forward signaling impairs T cell activation and proliferation in head and neck cancer.

Takashi Hirai, Yujiro Naito, Shohei Koyama, Yoshimitsu Nakanishi, Kentaro Masuhiro, Mayuko Izumi, Tomoki Kuge, Maiko Naito, Yumiko Mizuno, Yuta Yamaguchi, Sujin Kang, Moto Yaga, Yu Futami, Satoshi Nojima, Masayuki Nishide, Takayoshi Morita, Yasuhiro Kato, Takeshi Tsuda, Norihiko Takemoto, Yumi Kinugasa-Katayama, Taiki Aoshi, Jordan Kelly Villa, Kazuo Yamashita, Tomohiro Enokida, Yuta Hoshi, Kazuto Matsuura, Makoto Tahara, Hyota Takamatsu, Yoshito Takeda, Hidenori Inohara, Atsushi Kumanogoh

JCI insight　Vol. 9　No. 3　2024/02/08　Research paper (scientific journal)

Single-cell multi-omics analysis identifies two distinct phenotypes of newly-onset microscopic polyangiitis.

Masayuki Nishide, Kei Nishimura, Hiroaki Matsushita, Ryuya Edahiro, Sachi Inukai, Hiroshi Shimagami, Shoji Kawada, Yasuhiro Kato, Takahiro Kawasaki, Kohei Tsujimoto, Hokuto Kamon, Ryusuke Omiya, Yukinori Okada, Kunihiro Hattori, Masashi Narazaki, Atsushi Kumanogoh

Nature communications　Vol. 14　No. 1　p. 5789-5789　2023/10/11　Research paper (scientific journal)

Secretion of mitochondrial DNA via exosomes promotes inflammation in Behçet's syndrome.

Hachiro Konaka, Yasuhiro Kato, Toru Hirano, Kohei Tsujimoto, JeongHoon Park, Taro Koba, Wataru Aoki, Yusei Matsuzaki, Masayasu Taki, Shohei Koyama, Eri Itotagawa, Tatsunori Jo, Takehiro Hirayama, Taro Kawai, Ken J Ishii, Mitsuyoshi Ueda, Shigehiro Yamaguchi, Shizuo Akira, Takayoshi Morita, Yuichi Maeda, Masayuki Nishide, Sumiyuki Nishida, Yoshihito Shima, Masashi Narazaki, Hyota Takamatsu, Atsushi Kumanogoh

The EMBO journal　Vol. 42　No. 20　2023/09/04　Research paper (scientific journal)

Single-cell Raman microscopy with machine learning highlights distinct biochemical features of neutrophil extracellular traps and necrosis.

Patrick Michael Lelliott, Alison Jane Hobro, Nicolas Pavillon, Masayuki Nishide, Yasutaka Okita, Yumiko Mizuno, Sho Obata, Shinichiro Nameki, Hanako Yoshimura, Atsushi Kumanogoh, Nicholas Isaac Smith

Scientific reports　Vol. 13　No. 1　p. 10093-10093　2023/06/21　Research paper (scientific journal)

Tumor-derived semaphorin 4A improves PD-1-blocking antibody efficacy by enhancing CD8+ T cell cytotoxicity and proliferation.

Yujiro Naito, Shohei Koyama, Kentaro Masuhiro, Takashi Hirai, Takeshi Uenami, Takako Inoue, Akio Osa, Hirotomo Machiyama, Go Watanabe, Nicolas Sax, Jordan Villa, Yumi Kinugasa-Katayama, Satoshi Nojima, Moto Yaga, Yuki Hosono, Daisuke Okuzaki, Shingo Satoh, Takeshi Tsuda, Yoshimitsu Nakanishi, Yasuhiko Suga, Takayoshi Morita, Kiyoharu Fukushima, Masayuki Nishide, Takayuki Shiroyama, Kotaro Miyake, Kota Iwahori, Haruhiko Hirata, Izumi Nagatomo, Yukihiro Yano, Motohiro Tamiya, Toru Kumagai, Norihiko Takemoto, Hidenori Inohara, Sho Yamasaki, Kazuo Yamashita, Taiki Aoshi, Esra A Akbay, Naoki Hosen, Yasushi Shintani, Hyota Takamatsu, Masahide Mori, Yoshito Takeda, Atsushi Kumanogoh

Science advances　Vol. 9　No. 20　2023/05/19　Research paper (scientific journal)

Semaphorin 6D-expressing mesenchymal cells regulate IL-10 production by ILC2s in the lung.

Maiko Naito, Yoshimitsu Nakanishi, Yasutaka Motomura, Hyota Takamatsu, Shohei Koyama, Masayuki Nishide, Yujiro Naito, Mayuko Izumi, Yumiko Mizuno, Yuta Yamaguchi, Satoshi Nojima, Daisuke Okuzaki, Atsushi Kumanogoh

Life science alliance　Vol. 5　No. 11　2022/11　Research paper (scientific journal)

SLE stratification based on BAFF and IFN-I bioactivity for biologics and implications of BAFF produced by glomeruli in lupus nephritis.

Eri Itotagawa, Yoshihiko Tomofuji, Yasuhiro Kato, Hachiro Konaka, Kohei Tsujimoto, JeongHoon Park, Daiki Nagira, Takehiro Hirayama, Tatsunori Jo, Toru Hirano, Takayoshi Morita, Masayuki Nishide, Sumiyuki Nishida, Yoshihito Shima, Masashi Narazaki, Yukinori Okada, Hyota Takamatsu, Atsushi Kumanogoh

Rheumatology (Oxford, England)　Vol. 62　No. 5　p. 1988-1997　2022/09/12　Research paper (scientific journal)

The proliferative activity levels of each immune cell population evaluated by mass cytometry are linked to the clinical phenotypes of systemic lupus erythematosus.

Kajihara Akiko, Takayoshi Morita, Yasuhiro Kato, Hachiro Konaka, Teruaki Murakami, Yuta Yamaguchi, Shohei Koyama, Hyota Takamatsu, Masayuki Nishide, Yuichi Maeda, Akane Watanabe, Sumiyuki Nishida, Toru Hirano, Yoshihito Shima, Masashi Narazaki, Atsushi Kumanogoh

International immunology　Vol. 35　No. 1　p. 27-41　2022/08/23　Research paper (scientific journal)

Anterior chamber flare and ciliochoroidal detachment using flare photometry and anterior segment optical coherence tomography in acute lupus choroidopathy: A case report.

Satoko Fujimoto, Taku Wakabayashi, Kazuichi Maruyama, Chikako Hara, Eri Oguro-Igashira, Masayuki Nishide, Hirokazu Sakaguchi, Atsushi Kumanogoh, Kohji Nishida

American journal of ophthalmology case reports　Vol. 25　p. 101314-101314　2022/03

Cellular Adhesion Is a Controlling Factor in Neutrophil Extracellular Trap Formation Induced by Anti-Neutrophil Cytoplasmic Antibodies.

Patrick M Lelliott, Masayuki Nishide, Nicolas Pavillon, Yasutaka Okita, Takayuki Shibahara, Yumiko Mizuno, Hanako Yoshimura, Sho Obata, Atsushi Kumanogoh, Nicholas I Smith

ImmunoHorizons　Vol. 6　No. 2　p. 170-183　2022/02/22　Research paper (scientific journal)

Continuous Use of Etanercept During Pregnancy Does Not Affect TNF-Alpha Levels in Umbilical Cord Blood.

Masayuki Nishide, Mayu Yagita, Atsushi Kumanogoh

Biologics : targets & therapy　Vol. 16　p. 17-19　2022　Research paper (scientific journal)

The lysosomal Ragulator complex plays an essential role in leukocyte trafficking by activating myosin II

Takeshi Nakatani, Kohei Tsujimoto, Jeong Hoon Park, Tatsunori Jo, Tetsuya Kimura, Yoshitomo Hayama, Hachiro Konaka, Takayoshi Morita, Yasuhiro Kato, Masayuki Nishide, Shyohei Koyama, Shigeyuki Nada, Masato Okada, Hyota Takamatsu, Atsushi Kumanogoh

Nature Communications　Vol. 12　No. 1　p. 3333-3333　2021/12　Research paper (scientific journal)

IL-33 Induces Sema4A Expression in Dendritic Cells and Exerts Antitumor Immunity.

Yasuhiko Suga, Izumi Nagatomo, Yuhei Kinehara, Shohei Koyama, Daisuke Okuzaki, Akio Osa, Yujiro Naito, Hyota Takamatsu, Masayuki Nishide, Satoshi Nojima, Daisuke Ito, Takeshi Tsuda, Takeshi Nakatani, Yoshimitsu Nakanishi, Yu Futami, Taro Koba, Shingo Satoh, Yuki Hosono, Kotaro Miyake, Kiyoharu Fukushima, Takayuki Shiroyama, Kota Iwahori, Haruhiko Hirata, Yoshito Takeda, Atsushi Kumanogoh

Journal of immunology (Baltimore, Md. : 1950)　Vol. 207　No. 5　p. 1456-1467　2021/09/01　Research paper (scientific journal)

Pulmonary artery hypertension prior to the relapse of adult-onset Still's disease.

Yuki Hara, Takayoshi Morita, Katsunao Tanaka, Fusako Sera, Yasushi Sakata, Masayuki Nishide, Yuichi Maeda, Masashi Narazaki, Atsushi Kumanogoh

Respirology case reports　Vol. 9　No. 5　2021/05　Research paper (scientific journal)

Recovery from prolonged thrombocytopenia in patients with TAFRO syndrome: case series and literature review.

Yuta Yamaguchi, Yuichi Maeda, Takayuki Shibahara, Shinichiro Nameki, Akihiko Nakabayashi, Kiyohide Komuta, Yumiko Mizuno, Mayu Yagita, Yusuke Manabe, Takayoshi Morita, Masayuki Nishide, Akane Watanabe, Hyota Takamatsu, Sumiyuki Nishida, Toru Hirano, Yoshihito Shima, Masashi Narazaki, Atsushi Kumanogoh

Modern rheumatology case reports　Vol. 4　No. 2　p. 302-309　2020/07　Research paper (scientific journal)

Pathological and therapeutic implications of eosinophil-derived semaphorin 4D in eosinophilic chronic rhinosinusitis.

Takeshi Tsuda, Masayuki Nishide, Yohei Maeda, Yoshitomo Hayama, Shohei Koyama, Satoshi Nojima, Hyota Takamatsu, Daisuke Okuzaki, Takayoshi Morita, Takeshi Nakatani, Yasuhiro Kato, Yoshimitsu Nakanishi, Yu Futami, Yasuhiko Suga, Yujiro Naito, Hachiro Konaka, Shingo Satoh, Maiko Naito, Mayuko Izumi, Sho Obata, Ayaka Nakatani, Takashi Shikina, Kazuya Takeda, Masaki Hayama, Hidenori Inohara, Atsushi Kumanogoh

The Journal of allergy and clinical immunology　Vol. 145　No. 3　p. 843-854　2020/03　Research paper (scientific journal)

Single-incision laparoscopic colectomy for ascending colon tumor with relapsing polychondritis.

Ryugo Teranishi, Norikatsu Miyoshi, Kansuke Kido, Masayuki Nishide, Shiki Fujino, Takayuki Ogino, Hidekazu Takahashi, Mamoru Uemura, Chu Matsuda, Tsunekazu Mizusima, Masaki Mori, Yuichiro Doki

Asian journal of endoscopic surgery　Vol. 13　No. 4　p. 569-573　2020/02/03　Research paper (scientific journal)

OCTA, a sensitive screening for asymptomatic retinopathy, raises alarm over systemic involvements in patients with SLE.

Yumiko Mizuno, Masayuki Nishide, Taku Wakabayashi, Kohji Nishida, Atsushi Kumanogoh

Annals of the rheumatic diseases　Vol. 79　No. 2　2020/02

Single Cell Analysis of Neutrophils NETs by Microscopic LSPR Imaging System.

Riyaz Ahmad Mohamed Ali, Daiki Mita, Wilfred Espulgar, Masato Saito, Masayuki Nishide, Hyota Takamatsu, Hiroyuki Yoshikawa, Eiichi Tamiya

Micromachines　Vol. 11　No. 1　2019/12/31　Research paper (scientific journal)

SEMA4A promotes eosinophil survival and contributes to eosinophil-mediated allergic diseases.

Yohei Maeda, Takeshi Tsuda, Yoshito Takeda, Shohei Koyama, Yoshitomo Hayama, Satoshi Nojima, Tetsuya Kimura, Daisuke Ito, Hyota Takamatsu, Sujin Kang, Masayuki Nishide, Keiko Morimoto, Takashi Hosokawa, Yuhei Kinehara, Yasuhiro Kato, Takeshi Nakatani, Kazuya Takeda, Masaki Hayama, Sho Obata, Hitoshi Akazawa, Takashi Shikina, Hidenori Inohara, Atsushi Kumanogoh

Allergology international : official journal of the Japanese Society of Allergology　Vol. 68　No. 2　p. 274-276　2019/04

Eosinophil-derived neurotoxin enhances airway remodeling in eosinophilic chronic rhinosinusitis and correlates with disease severity.

Takeshi Tsuda, Yohei Maeda, Masayuki Nishide, Shohei Koyama, Yoshitomo Hayama, Satoshi Nojima, Hyota Takamatsu, Daisuke Okuzaki, Yuhei Kinehara, Yasuhiro Kato, Takeshi Nakatani, Sho Obata, Hitoshi Akazawa, Takashi Shikina, Kazuya Takeda, Masaki Hayama, Hidenori Inohara, Atsushi Kumanogoh

International immunology　Vol. 31　No. 1　p. 33-40　2019/02/06　Research paper (scientific journal)

Development and validation of a deep-learning model for scoring of radiographic finger joint destruction in rheumatoid arthritis.

Toru Hirano, Masayuki Nishide, Naoki Nonaka, Jun Seita, Kosuke Ebina, Kazuhiro Sakurada, Atsushi Kumanogoh

Rheumatology advances in practice　Vol. 3　No. 2　2019　Research paper (scientific journal)

Semaphorin 7A promotes EGFR-TKI resistance in EGFR mutant lung adenocarcinoma cells.

Yuhei Kinehara, Izumi Nagatomo, Shohei Koyama, Daisuke Ito, Satoshi Nojima, Ryota Kurebayashi, Yoshimitsu Nakanishi, Yasuhiko Suga, Yu Nishijima-Futami, Akio Osa, Takeshi Nakatani, Yasuhiro Kato, Masayuki Nishide, Yoshitomo Hayama, Masayoshi Higashiguchi, Osamu Morimura, Kotaro Miyake, Sujin Kang, Toshiyuki Minami, Haruhiko Hirata, Kota Iwahori, Takayuki Takimoto, Hyota Takamatsu, Yoshito Takeda, Naoki Hosen, Shigenori Hoshino, Yasushi Shintani, Meinoshin Okumura, Toru Kumagai, Kazumi Nishino, Fumio Imamura, Shin-Ichi Nakatsuka, Takashi Kijima, Hiroshi Kida, Atsushi Kumanogoh

JCI insight　Vol. 3　No. 24　2018/12/20　Research paper (scientific journal)

Apoptosis-derived membrane vesicles drive the cGAS-STING pathway and enhance type I IFN production in systemic lupus erythematosus.

Yasuhiro Kato, JeongHoon Park, Hyota Takamatsu, Hachirou Konaka, Wataru Aoki, Syunsuke Aburaya, Mitsuyoshi Ueda, Masayuki Nishide, Shohei Koyama, Yoshitomo Hayama, Yuhei Kinehara, Toru Hirano, Yoshihito Shima, Masashi Narazaki, Atsushi Kumanogoh

Annals of the rheumatic diseases　Vol. 77　No. 10　p. 1507-1515　2018/10　Research paper (scientific journal)

Lysosomal Protein Lamtor1 Controls Innate Immune Responses via Nuclear Translocation of Transcription Factor EB.

Yoshitomo Hayama, Tetsuya Kimura, Yoshito Takeda, Shigeyuki Nada, Shohei Koyama, Hyota Takamatsu, Sujin Kang, Daisuke Ito, Yohei Maeda, Masayuki Nishide, Satoshi Nojima, Hana Sarashina-Kida, Takashi Hosokawa, Yuhei Kinehara, Yasuhiro Kato, Takeshi Nakatani, Yoshimitsu Nakanishi, Takeshi Tsuda, Taro Koba, Masato Okada, Atsushi Kumanogoh

Journal of immunology (Baltimore, Md. : 1950)　Vol. 200　No. 11　p. 3790-3800　2018/06/01　Research paper (scientific journal)

Semaphorin 6D reverse signaling controls macrophage lipid metabolism and anti-inflammatory polarization.

Sujin Kang, Yoshimitsu Nakanishi, Yoshiyuki Kioi, Daisuke Okuzaki, Tetsuya Kimura, Hyota Takamatsu, Shohei Koyama, Satoshi Nojima, Masayuki Nishide, Yoshitomo Hayama, Yuhei Kinehara, Yasuhiro Kato, Takeshi Nakatani, Tomomi Shimogori, Junichi Takagi, Toshihiko Toyofuku, Atsushi Kumanogoh

Nature immunology　Vol. 19　No. 6　p. 561-570　2018/06　Research paper (scientific journal)

The role of semaphorins in immune responses and autoimmune rheumatic diseases.

Masayuki Nishide, Atsushi Kumanogoh

Nature reviews. Rheumatology　Vol. 14　No. 1　p. 19-31　2018/01　Research paper (scientific journal)

Lamtor1 Is Critically Required for CD4+ T Cell Proliferation and Regulatory T Cell Suppressive Function.

Takashi Hosokawa, Tetsuya Kimura, Shigeyuki Nada, Tatsusada Okuno, Daisuke Ito, Sujin Kang, Satoshi Nojima, Kazuya Yamashita, Takeshi Nakatani, Yoshitomo Hayama, Yasuhiro Kato, Yuhei Kinehara, Masayuki Nishide, Norihisa Mikami, Syohei Koyama, Hyota Takamatsu, Daisuke Okuzaki, Naganari Ohkura, Shimon Sakaguchi, Masato Okada, Atsushi Kumanogoh

Journal of immunology (Baltimore, Md. : 1950)　Vol. 199　No. 6　p. 2008-2019　2017/09/15　Research paper (scientific journal)

Semaphorin 4D inhibits neutrophil activation and is involved in the pathogenesis of neutrophil-mediated autoimmune vasculitis.

Masayuki Nishide, Satoshi Nojima, Daisuke Ito, Hyota Takamatsu, Shohei Koyama, Sujin Kang, Tetsuya Kimura, Keiko Morimoto, Takashi Hosokawa, Yoshitomo Hayama, Yuhei Kinehara, Yasuhiro Kato, Takeshi Nakatani, Yoshimitsu Nakanishi, Takeshi Tsuda, Jeong Hoon Park, Toru Hirano, Yoshihito Shima, Masashi Narazaki, Eiichi Morii, Atsushi Kumanogoh

Annals of the rheumatic diseases　Vol. 76　No. 8　p. 1440-1448　2017/08　Research paper (scientific journal)

Erratum: Polarization of M2 macrophages requires Lamtor1 that integrates cytokine and amino-acid signals.

Tetsuya Kimura, Shigeyuki Nada, Noriko Takegahara, Tatsusada Okuno, Satoshi Nojima, Sujin Kang, Daisuke Ito, Keiko Morimoto, Takashi Hosokawa, Yoshitomo Hayama, Yuichi Mitsui, Natsuki Sakurai, Hana Sarashina-Kida, Masayuki Nishide, Yohei Maeda, Hyota Takamatsu, Daisuke Okuzaki, Masaki Yamada, Masato Okada, Atsushi Kumanogoh

Nature communications　Vol. 8　p. 14711-14711　2017/02/27　Research paper (scientific journal)

Polarization of M2 macrophages requires Lamtor1 that integrates cytokine and amino-acid signals.

Tetsuya Kimura, Shigeyuki Nada, Noriko Takegahara, Tatsusada Okuno, Satoshi Nojima, Sujin Kang, Daisuke Ito, Keiko Morimoto, Takashi Hosokawa, Yoshitomo Hayama, Yuichi Mitsui, Natsuki Sakurai, Hana Sarashina-Kida, Masayuki Nishide, Yohei Maeda, Hyota Takamatsu, Daisuke Okuzaki, Masaki Yamada, Masato Okada, Atsushi Kumanogoh

Nature communications　Vol. 7　p. 13130-13130　2016/10/12　Research paper (scientific journal)

LRRK1 is critical in the regulation of B-cell responses and CARMA1-dependent NF-κB activation.

Keiko Morimoto, Yoshihiro Baba, Hisaaki Shinohara, Sujin Kang, Satoshi Nojima, Tetsuya Kimura, Daisuke Ito, Yuji Yoshida, Yohei Maeda, Hana Sarashina-Kida, Masayuki Nishide, Takashi Hosokawa, Yasuhiro Kato, Yoshitomo Hayama, Yuhei Kinehara, Tatsusada Okuno, Hyota Takamatsu, Toru Hirano, Yoshihito Shima, Masashi Narazaki, Tomohiro Kurosaki, Toshihiko Toyofuku, Atsushi Kumanogoh

Scientific reports　Vol. 6　p. 25738-25738　2016/05/11　Research paper (scientific journal)

Oral tacrolimus for the treatment of generalized morphea

Ayaki Hirohata, Takaaki Hanafusa, Ken Igawa, Tomoko Inoue-Nishimoto, Eriko Mabuchi-Kiyohara, Masayuki Nishide, Hiroo Yokozeki, Ryuta Ikegami

EUROPEAN JOURNAL OF DERMATOLOGY　Vol. 26　No. 1　p. 112-113　2016/01

Optimization of Treatment Intervals of Tocilizumab and Golimumab By Measuring Serum Trough Levels in Rheumatoid Arthritis Patients

Yoshinobu Matsuura, Masashi Narazaki, Masayuki Nishide, Yasuhiro Kato, Hideki Yorifuji, Toru Hirano, Yoshihito Shima, Toshio Tanaka, Atsushi Ogata, Atsushi Kumanogoh

ARTHRITIS & RHEUMATOLOGY　Vol. 67　p. 815-816　2015/10　Research paper (other academic)

mTOR Complex Signaling through the SEMA4A-Plexin B2 Axis Is Required for Optimal Activation and Differentiation of CD8+ T Cells.

Daisuke Ito, Satoshi Nojima, Masayuki Nishide, Tatsusada Okuno, Hyota Takamatsu, Sujin Kang, Tetsuya Kimura, Yuji Yoshida, Keiko Morimoto, Yohei Maeda, Takashi Hosokawa, Toshihiko Toyofuku, Jun Ohshima, Daisuke Kamimura, Masahiro Yamamoto, Masaaki Murakami, Eiichi Morii, Hiromi Rakugi, Yoshitaka Isaka, Atsushi Kumanogoh

Journal of immunology (Baltimore, Md. : 1950)　Vol. 195　No. 3　p. 934-43　2015/08/01　Research paper (scientific journal)

Semaphorin 4D Contributes to Rheumatoid Arthritis by Inducing Inflammatory Cytokine Production: Pathogenic and Therapeutic Implications.

Yuji Yoshida, Atsushi Ogata, Sujin Kang, Kousuke Ebina, Kenrin Shi, Satoshi Nojima, Tetsuya Kimura, Daisuke Ito, Keiko Morimoto, Masayuki Nishide, Takashi Hosokawa, Toru Hirano, Yoshihito Shima, Masashi Narazaki, Hideki Tsuboi, Yukihiko Saeki, Tetsuya Tomita, Toshio Tanaka, Atsushi Kumanogoh

Arthritis & rheumatology (Hoboken, N.J.)　Vol. 67　No. 6　p. 1481-90　2015/06　Research paper (scientific journal)

Immune reconstitution inflammatory syndrome in a patient with adult-onset Still's disease: Graft-versus-host-like skin reaction with possible asymptomatic human herpes virus reactivation during steroid tapering

Kosuke Yamaga, Takaaki Hanafusa, Hiroaki Azukizawa, Atsushi Tanemura, Takuro Nii, Masayuki Nishide, Masashi Narazaki, Ichiro Katayama

European Journal of Dermatology　Vol. 24　No. 1　p. 101-103　2014/01　Research paper (scientific journal)

Improvement of health status evaluated by Arthritis Impact Measurement Scale 2 (AIMS-2) and Short Form-36 (SF-36) in patients with rheumatoid arthritis treated with tocilizumab.

Mie Fusama, Hideko Nakahara, Yoshimasa Hamano, Masayuki Nishide, Keisuke Kawamoto, Takashi Hosokawa, Satoko Nozato, Shinji Higa, Tsuyoshi Igarashi, Eiji Takeuchi, Takanori Kuroiwa, Yasunori Shimaoka, Masao Yukioka, Yasushi Miura, Kayoko Higashi, Taro Kuritani, Keiji Maeda

Modern rheumatology　Vol. 23　No. 2　p. 276-83　2013/03　Research paper (scientific journal)

P-373 気管支喘息,好酸球性副鼻腔炎を先行したIgG4-Mikulicz病の一例(膠原病の臓器障害と治療,ポスター発表,一般演題)

中林 晃彦, 楢崎 雅司, 新居 卓朗, 西出 真之, 濱野 芳匡, 平野 享, 嶋 良仁, 緒方 篤, 田中 敏郎, 熊ノ郷 淳

アレルギー　Vol. 62　No. 3　p. 480-480　2013

A case report of a patient with rheumatoid arthritis complicated with Mycobacterium avium during tocilizumab treatment.

Hideko Nakahara, Yosuke Kamide, Yoshimasa Hamano, Takashi Hosokawa, Masayuki Nishide, Yu Lin, Keisuke Kawamoto, Mie Fusama, Shinji Higa, Takashi Kuroiwa, Tsuyoshi Igarashi, Taro Kuritani, Keiji Maeda

Modern rheumatology　Vol. 21　No. 6　p. 655-9　2011/12　Research paper (scientific journal)