In vitro liver models for toxicological research.

Ichiro Fukunaga, Takanori Takebe

Drug metabolism and pharmacokinetics　Vol. 62　p. 101478-101478　2025/06　Research paper (scientific journal)

Publisher Correction: Multi-zonal liver organoids from human pluripotent stem cells.

Hasan Al Reza, Connie Santangelo, Kentaro Iwasawa, Abid Al Reza, Sachiko Sekiya, Kathryn Glaser, Alexander Bondoc, Jonathan Merola, Takanori Takebe

Nature　Vol. 642　No. 8067　2025/06

Engineering Large-Scale and Innervated Functional Human Gut for Transplantation.

Holly M Poling, Théo Noël, Akaljot Singh, Garrett W Fisher, Konrad Thorner, Praneet Chaturvedi, Kalpana Nattamai, Kalpana Srivastava, Matthew R Batie, Taylor Hausfeld, Amy L Pitstick, Séverine Ménoret, Ignacio Anegon, Riccardo Barrile, Christopher N Mayhew, Takanori Takebe, James M Wells, Michael A Helmrath, Maxime M Mahe

bioRxiv : the preprint server for biology　2025/05/27　Research paper (scientific journal)

Multi-zonal liver organoids from human pluripotent stem cells.

Hasan Al Reza, Connie Santangelo, Kentaro Iwasawa, Abid Al Reza, Sachiko Sekiya, Kathryn Glaser, Alexander Bondoc, Jonathan Merola, Takanori Takebe

Nature　Vol. 641　No. 8065　p. 1258-1267　2025/05　Research paper (scientific journal)

Gene editing enables non-invasive in vivo PET imaging of human induced pluripotent stem cell-derived liver bud organoids.

Candice Ashmore-Harris, Hiroaki Ayabe, Emi Yoshizawa, Tetsu Arisawa, Yuuki Takada, Takanori Takebe, Gilbert O Fruhwirth

Molecular therapy. Methods & clinical development　Vol. 33　No. 1　p. 101406-101406　2025/03/13　Research paper (scientific journal)

Eicosatetraynoic Acid Regulates Profibrotic Pathways in an Induced Pluripotent Stem Cell-Derived Macrophage-Human Intestinal Organoid Model of Crohn's Disease.

Ingrid Jurickova, Benjamin W Dreskin, Elizabeth Angerman, Erin Bonkowski, Jack Nguyen, Richard Villarreal, Kentaro Tominaga, Kentaro Iwasawa, Tzipi Braun, Takanori Takebe, Michael A Helmrath, Yael Haberman, James M Wells, Lee A Denson

Journal of Crohn's & colitis　Vol. 19　No. 2　2025/02/04　Research paper (scientific journal)

ACMSD inhibition corrects fibrosis, inflammation, and DNA damage in MASLD/MASH.

Yasmine J Liu, Masaki Kimura, Xiaoxu Li, Jonathan Sulc, Qi Wang, Sandra Rodríguez-López, Angelique M L Scantlebery, Keno Strotjohann, Hector Gallart-Ayala, Archana Vijayakumar, Robert P Myers, Julijana Ivanisevic, Riekelt H Houtkooper, G Mani Subramanian, Takanori Takebe, Johan Auwerx

Journal of hepatology　Vol. 82　No. 2　p. 174-188　2025/02　Research paper (scientific journal)

Matrix stiffness modulated release of spheroid-derived extracellular vesicles and discovery of Piezo1 cargo.

Maulee Sheth, Manju Sharma, Supasek Kongsomros, Maria Lehn, Takanori Takebe, Vinita Takiar, Trisha Wise-Draper, Somchai Chutipongtanate, Leyla Esfandiari

bioRxiv : the preprint server for biology　2025/01/17　Research paper (scientific journal)

A Gamified N-back App for Identifying Mild-cognitive Impairment in Older Adults.

Naohiro Murata, Shozo Nishii, Ryoya Usuha, Asuka Kodaka, Masako Fujimori, Haruka Sugawara, Takashi Kiriyama, Hirotake Uchikado, Yasuo Okumura, Takanori Takebe

JMA journal　Vol. 8　No. 1　p. 174-182　2025/01/15　Research paper (scientific journal)

In toto biological framework: Modeling interconnectedness during human development.

Yosuke Yoneyama, Yunheng Wu, Kensaku Mori, Takanori Takebe

Developmental cell　Vol. 60　No. 1　p. 8-20　2025/01/06　Research paper (scientific journal)

Deriving Human Intestinal Organoids with Functional Tissue-Resident Macrophages All From Pluripotent Stem Cells.

Kentaro Tominaga, Daniel O Kechele, J Guillermo Sanchez, Simon Vales, Ingrid Jurickova, Lizza Roman, Akihiro Asai, Jacob R Enriquez, Heather A McCauley, Keishi Kishimoto, Kentaro Iwasawa, Akaljot Singh, Yuko Horio, Jorge O Múnera, Takanori Takebe, Aaron M Zorn, Michael A Helmrath, Lee A Denson, James M Wells

Cellular and molecular gastroenterology and hepatology　Vol. 19　No. 4　p. 101444-101444　2025　Research paper (scientific journal)

Fetal Liver-like Organoids Recapitulate Blood-Liver Niche Development and Multipotent Hematopoiesis from Human Pluripotent Stem Cells.

Milad Rezvani, Kyle Lewis, Susanna Quach, Kentaro Iwasawa, Julian Weihs, Hasan Reza, Yuqi Cai, Masaki Kimura, RanRan Zhang, Yuka Milton, Praneet Chaturvedi, Konrad Thorner, Ramesh C Nayak, Jorge O Munera, Phillip Kramer, Brian Davis, Appakalai Balamurugan, Yeni Ait Ahmed, Marcel Finke, Rose Yinghan Behncke, Adrien Guillot, Rene Haegerling, Julia Polansky, Philip Bufler, Jose Cancelas, James Wells, Momoko Yoshimoto, Takanori Takebe

bioRxiv : the preprint server for biology　2024/10/12　Research paper (scientific journal)

Human pluripotent stem cell-derived organoids repair damaged bowel in vivo.

Holly M Poling, Nambirajan Sundaram, Garrett W Fisher, Akaljot Singh, Joseph R Shiley, Kalpana Nattamai, Vinothini Govindarajah, Alexander R Cortez, Maksym O Krutko, Séverine Ménoret, Ignacio Anegon, Magdalena Kasendra, James M Wells, Christopher N Mayhew, Takanori Takebe, Maxime M Mahe, Michael A Helmrath

Cell stem cell　Vol. 31　No. 10　p. 1513-1523　2024/10/03　Research paper (scientific journal)

Three-dimensional matrix stiffness modulates mechanosensitive and phenotypic alterations in oral squamous cell carcinoma spheroids.

Maulee Sheth, Manju Sharma, Maria Lehn, HasanAl Reza, Takanori Takebe, Vinita Takiar, Trisha Wise-Draper, Leyla Esfandiari

APL bioengineering　Vol. 8　No. 3　p. 036106-036106　2024/09　Research paper (scientific journal)

Self-Assembled Generation of Multi-zonal Liver Organoids from Human Pluripotent Stem Cells.

Hasan Al Reza, Connie Santangelo, Abid Al Reza, Kentaro Iwasawa, Sachiko Sachiko, Kathryn Glaser, Alexander Bondoc, Jonathan Merola, Takanori Takebe

bioRxiv : the preprint server for biology　2024/08/30　Research paper (scientific journal)

In vitro human cell-based models: What can they do and what are their limitations?

Matthias P Lutolf, Milica Radisic, Jeffrey Beekman, Dan Dongeun Huh, Meritxell Huch, Margherita Yayoi Turco, Zeinab Niloofar Tahmasebi Birgani, Dong Gao, Rui Yao, Hang Lin, Takanori Takebe

Cell　Vol. 187　No. 17　p. 4439-4443　2024/08/22　Research paper (scientific journal)

Enhanced Piezoelectric Performance of PVDF-TrFE Nanofibers through Annealing for Tissue Engineering Applications.

Maksym Krutko, Holly M Poling, Andrew E Bryan, Manju Sharma, Akaljot Singh, Hasan A Reza, Kathryn A Wikenheiser-Brokamp, Takanori Takebe, Michael A Helmrath, Greg M Harris, Leyla Esfandiari

bioRxiv : the preprint server for biology　2024/08/19　Research paper (scientific journal)

Inter-cellular mRNA Transfer Alters Human Pluripotent Stem Cell State.

Yosuke Yoneyama, Ran-Ran Zhang, Masaki Kimura, Yuqi Cai, Mike Adam, Sreeja Parameswaran, Hideki Masaki, Naoaki Mizuno, Joydeep Bhadury, So Maezawa, Hiroshi Ochiai, Hiromitsu Nakauchi, S Steven Potter, Matthew T Weirauch, Takanori Takebe

bioRxiv : the preprint server for biology　2024/06/27　Research paper (scientific journal)

Deciphering Endothelial and Mesenchymal Organ Specification in Vascularized Lung and Intestinal Organoids

Miao Y, Tan C, Pek NM, Yu Z, Iwasawa K, Kechele DO, Sundaram N, Pastrana-Gomez V, Kishimoto K, Yang M, Jiang C, Tchieu J, Whitsett JA, McCracken KW, Rottier RJ, Kotton DN, Helmrath MA, Wells JM, Takebe T, Zorn AM, Chen Y, Guo M, Gu M

bioRxiv　2024/02　Research paper (scientific journal)

Quality Control of Stem Cell-Based Cultured Meat According to Specific Differentiation Abilities.

Yuna Naraoka, Yo Mabuchi, Mai Kiuchi, Kyoko Kumagai, Daisuke Hisamatsu, Yosuke Yoneyama, Takanori Takebe, Chihiro Akazawa

Cells　Vol. 13　No. 2　2024/01/11　Research paper (scientific journal)

Eicosatetraynoic Acid Regulates Pro-Fibrotic Pathways in an Induced Pluripotent Stem Cell Derived Macrophage:Human Intestinal Organoid Model of Crohn’s Disease

Jurickova I, Dreskin BW, Angerman E, Bonkowski E, Tominaga K, Iwasawa K, Braun T, Takebe T, Helmrath MA, Haberman Y, Wells JM, Denson LA

bioRxiv　2024/01　Research paper (scientific journal)

Synthetic augmentation of bilirubin metabolism in human pluripotent stem cell-derived liver organoids

Reza H, Farooqui Z, Reza A, Conroy C, Iwasawa K, Ogura Y, Okita K, Osafune K, Takebe T

Stem Cell Reports　Vol. 8　No. 11　2023/11　Research paper (scientific journal)

Development of functional resident macrophages in human pluripotent stem cell-derived colonic organoids and human fetal colon

Múnera JO, Kechele DO, Bouffi C, Qu N, Jing R, Maity P, Enriquez JR, Han, Campbell I, Mahe MM, McCauley HA, Zhang X, Sundaram N, Hudson JR, Zarsozo-Lacoste A, Pradhan S, Tominaga K, Sanchez JG, Weiss AAChatuvedi P, Spence JR, Hachimi M, North T, Daley GQ, Mayhew CN, Hu Y, Takebe T, Helmrath MA, Wells JM

Cell Stem Cell　Vol. 30　No. 11　p. 1434-1451　2023/11　Research paper (scientific journal)

Complement factor D targeting protects endotheliopathy in organoid and monkey models of COVID-19

Kawakami E, Saiki N, Yoneyama Y, Takayama K, Nio Y, Takebe T

Cell Stem Cell　Vol. 30　No. 10　p. 1315-1330　2023/10　Research paper (scientific journal)

Preparation of mechanically patterned hydrogels for controlling the self-condensation of cells

Takahisa Matsuzaki, Yuma Kawano, Momoka Horikiri, Yuko Shimokawa, Takashi Yamazaki, Nao Okuma, Hiroyuki Koike, Masaki Kimura, Ryuzo Kawamura, Yosuke Yoneyama, Yasuro Furuichi, Fumihiko Hakuno, Shin-Ichiro Takahashi, Seiichiro Nakabayashi, Satoshi Okamoto, Hiromitsu Nakauchi, Hideki Taniguchi, Takanori Takebe, Hiroshi Y. Yoshikawa

STAR Protocols　Vol. 4　No. 3　p. 102471-102471　2023/09　Research paper (scientific journal)

Self-organized yolk sac-like organoids allow for scalable generation of multipotent hematopoietic progenitor cells from human induced pluripotent stem cells

Tamaoki N, Siebert S, Maeda T, Ngoc-H Ha, Good M L, Huang Y, Vodnala S K, Haro-Mora J J, Uchida N, Tisdale J F, Sweeney C L, Choi U, Brault J, Koontz S, Malech H L, Yamazaki Y, Isonaka R, Goldstein

bioRxiv　Vol. 3　No. 4　p. 100460-100460　2023/04　Research paper (scientific journal)

Enteral liquid ventilation oxygenates a hypoxic pig model.

Tasuku Fujii, Yosuke Yoneyama, Akiko Kinebuchi, Naoki Ozeki, Sho Maeda, Norikazu Saiki, Toyofumi Fengshi Chen-Yoshikawa, Hiroshi Date, Kimitoshi Nishiwaki, Takanori Takebe

iScience　Vol. 26　No. 3　p. 106142-106142　2023/03/17　Research paper (scientific journal)

A Pillar and Perfusion Plate Platform for Robust Human Organoid Culture and Analysis

Kang S, Kimura M, Shrestha S, Lewis P, Lee S, Cai Y, Joshi P, Acharya P, Liu J, Yang Y, Sanchez J, Ayyagari S, Alsberg E, Wells J, Takebe T, Lee M

bioRxiv　2023/03　Research paper (scientific journal)

ENHANCED LIPOGENESIS ASSOCIATED WITH A HIGH-RISK GCKR VARIANT (rs1260326) IS EFFECTIVELY SUPPRESSED BY TLC-2716, A NOVEL, LIVER-TARGETED LXR INVERSE AGONIST IN STEATOTIC HUMAN …

Kimura M, Chuang JC, Vijayakumar A, Murakami E, Huss RS, Myers RP, Subramanian, M Takebe T

HEPATOLOGY　Vol. 76　p. S1280-S1281　2022/10　Research paper (scientific journal)

En masse organoid phenotyping informs metabolic-associated genetic susceptibility to NASH

Kimura M, Iguchi T, Iwasawa K, Dunn A, Thompson W, Yoneyama Y, Chaturvedi P, Zorn A, Wintzinger M, Quattrocelli M, Watanabe-Chailland M, Zhu G, Fujimoto M, Kumbaji M, Kodaka A, Gindin Y, Chung C, Myers R, Subramanian G, Hwa V, Takebe T

Cell　Vol. 185　No. 22　p. 4216-4232.e16　2022/10　Research paper (scientific journal)

Mechanical guidance of self-condensation patterns of differentiating progeny

Takahisa Matsuzaki, Yuko Shimokawa, Hiroyuki Koike, Masaki Kimura, Yuma Kawano, Nao Okuma, Ryuzo Kawamura, Yosuke Yoneyama, Yasuro Furuichi, Fumihiko Hakuno, Shin-Ichiro Takahashi, Seiichiro Nakabayashi, Satoshi Okamoto, Hiromitsu Nakauchi, Hideki Taniguchi, Takanori Takebe, Hiroshi Y. Yoshikawa

iScience　Vol. 25　No. 10　p. 105109-105109　2022/09　Research paper (scientific journal)

Anniversary reflections: Inspiring discoveries and the future of the field

Lancaster M, Morris S, Takebe T, Qian L, Gao S, Huch M

Cell Stem Cell　Vol. 29　No. 66　p. 879-881　2022/06　Research paper (scientific journal)

Cell membrane fluidity and ROS resistance define DMSO tolerance of cryopreserved synovial MSCs and HUVECs

Mitsuru Mizuno, Takahisa Matsuzaki, Nobutake Ozeki, Hisako Katano, Hideyuki Koga, Takanori Takebe, Hiroshi Y. Yoshikawa, Ichiro Sekiya

STEM CELL RESEARCH & THERAPY　Vol. 13　No. 1　2022/05　Research paper (scientific journal)

Eicosatetraynoic Acid and Butyrate Regulate Human Intestinal Organoid Mitochondrial and Extracellular Matrix Pathways Implicated in Crohn’s

Jurickova I, Bonkowski E, Angerman E, Novak E, Huron A, Akers G, Iwasawa K, Braun T, Hadar R, Hooker M, Han S, Cutler D, Okou D, Kugathasan S, Jegga A, Wells J, Takebe T, Mollen K, Haberman Y, Denson L

Inflammatory Bowel Diseases　Vol. 28　No. 7　p. 988-1003　2022/03　Research paper (scientific journal)

GENERATION OF HUMAN INTESTINAL ORGANOIDS CONTAINING TISSUE-RESIDENT IMMUNE CELLS

Tominaga K, Kechele D, Sanchez G, McCauley H, Enriquez J, Vales S, Jurickova I, Denson L, Takebe T, Helmrath M, Zorn A, Wells J

Gastroenterology　Vol. 62　No. 3　2022/02　Research paper (scientific journal)

Synthesis and application of POLYseq for profiling human liver organoids

Dunn A, Cai Y, Iwasawa K, Kimura M, Takebe T

STAR Protoc　Vol. 2　No. 4　p. 100976-100976　2021/12　Research paper (scientific journal)

Correction of a Factor VIII genomic inversion with designer-recombinases

Lansing F, Mukhametzyanova L, Rojo-Romanos T, Iwasawa K, Kimura M, Paszkowski-Rogacz M, Karpinski J, Grass T, Sonntag J, Schneider P. M, Guenes C, Hoersten J, Schmitt L. T, Rodriguez-Muela M, Knoefler R, Takebe T, Buchholz F

HUMAN GENE THERAPY　Vol. 32　No. 19-20　p. A16-A17　2021/10

MODELING LIVER FIBROSIS WITH LIVER ORGANOID

Ohori Momoko, Saiki Norikazu, Yashiro Hiroaki, Funata Masaki, Kono Tamaki, Ogawa Shinji, Nio Yasunori, Takebe Takanori

HEPATOLOGY　Vol. 74　p. 825A-825A　2021/10

Organoid Transplant Approaches for the Liver.

Reza HA, Ryo O, Takebe T

Transplant international : official journal of the European Society for Organ Transplantation　2021/10

POLYseq: A poly(β-amino ester)-based vector for multifunctional cellular barcoding.

Dunn A, Cai Y, Iwasawa K, Kimura M, Takebe T

Stem cell reports　Vol. 16　No. 9　p. 2149-2158　2021/09

Isolation and Characterization of Tissue Resident CD29-Positive Progenitor Cells in Livestock to Generate a Three-Dimensional Meat Bud.

Naraoka Y, Mabuchi Y, Yoneyama Y, Suto EG, Hisamatsu D, Ikeda M, Ito R, Nakamura T, Takebe T, Akazawa C

Cells　Vol. 10　No. 9　2021/09

Organogenesis in vitro.

Iwasawa K, Takebe T

Current opinion in cell biology　Vol. 73　p. 84-91　2021/08

Mammalian enteral ventilation ameliorates respiratory failure

Okabe R, Chen-Yoshikawa TF, Yoneyama Y, Kobayashi E, Date H, Takebe T

Med　Vol. 2　No. 6　p. 773-783　2021/05　Research paper (scientific journal)

Building consensus on definition and nomenclature of hepatic, pancreatic, and biliary organoids.

Marsee A, Roos FJM, Verstegen MMA, HPB Organoid Consortium, Gehart H, de Koning E, Lemaigre F, Forbes SJ, Peng WC, Huch M, Takebe T, Vallier L, Clevers H, van der Laan LJW, Spee B

Cell stem cell　Vol. 28　No. 5　p. 816-832　2021/05

Voices of biotech research.

Annabi N, Baker M, Boettiger A, Chakraborty D, Chen Y, Corbett KS, Correia B, Dahlman J, de Oliveira T, Ertuerk A, Yanik MF, Henaff E, Huch M, Iliev ID, Jacobs T, Junca H, Keung A, Kolodkin-Gal I, Krishnaswamy S, Lancaster M, Macosko E, Martínez-Núñez MA, Miura K, Molloy J, Cruz AO, Platt RJ, Posey AD Jr, Shao H, Simunovic M, Slavov N, Takebe T, Vandenberghe LH, Varshney RK, Wang J

Nature biotechnology　Vol. 39　No. 3　p. 281-286　2021/03

Common Genetic Variation in Humans Impacts In Vitro Susceptibility to SARS-CoV-2 Infection.

Dobrindt K, Hoagland DA, Seah C, Kassim B, O'Shea CP, Murphy A, Iskhakova M, Fernando MB, Powell SK, Deans PJM, Javidfar B, Peter C, Møller R, Uhl SA, Garcia MF, Kimura M, Iwasawa K, Crary JF, Kotton DN, Takebe T, Huckins LM, tenOever BR, Akbarian S, Brennand KJ

Stem cell reports　Vol. 16　No. 3　p. 505-518　2021/03

Fetal liver hematopoiesis: from development to delivery.

Lewis K, Yoshimoto M, Takebe T

Stem cell research & therapy　Vol. 12　No. 1　2021/02

Engineering human hepato-biliary-pancreatic organoids from pluripotent stem cells.

Koike H, Iwasawa K, Ouchi R, Maezawa M, Kimura M, Kodaka A, Nishii S, Thompson WL, Takebe T

Nature protocols　Vol. 16　No. 2　p. 919-936　2021/02

The promise of human organoids in the digestive system.

Funata M, Nio Y, Erion DM, Thompson WL, Takebe T

Cell death and differentiation　Vol. 28　No. 1　p. 84-94　2021/01

Simultaneous Zn²⁺ tracking in multiple organelles using super-resolution morphology-correlated organelle identification in living cells.

Fang H, Geng S, Hao M, Chen Q, Liu M, Liu C, Tian Z, Wang C, Takebe T, Guan JL, Chen Y, Guo Z, He W, Diao J

Nature communications　Vol. 12　No. 1　2021/01

Human liver model systems in a dish.

Thompson WL, Takebe T

Development, growth & differentiation　2021/01

Modeling Human Bile Acid Transport and Synthesis in Stem Cell-Derived Hepatocytes with a Patient-Specific Mutation.

Hayashi H, Osaka S, Sakabe K, Fukami A, Kishimoto E, Aihara E, Sabu Y, Mizutani A, Kusuhara H, Naritaka N, Zhang W, Huppert SS, Sakabe M, Nakamura T, Hu YC, Mayhew C, Setchell K, Takebe T, Asai A

Stem cell reports　Vol. 16　No. 2　p. 309-323　2020/12　Research paper (scientific journal)

Single cell transcriptomics identifies a signaling network coordinating endoderm and mesoderm diversification during foregut organogenesis

Lu Han, Praneet Chaturvedi, Keishi Kishimoto, Hiroyuki Koike, Talia Nasr, Kentaro Iwasawa, Kirsten Giesbrecht, Phillip C. Witcher, Alexandra Eicher, Lauren Haines, Yarim Lee, John M. Shannon, Mitsuru Morimoto, James M. Wells, Takanori Takebe, Aaron M. Zorn

Nature Communications　Vol. 11　No. 1　2020/12　Research paper (scientific journal)

Polygenic architecture informs potential vulnerability to drug-induced liver injury.

Koido M, Kawakami E, Fukumura J, Noguchi Y, Ohori M, Nio Y, Nicoletti P, Aithal GP, Daly AK, Watkins PB, Anayama H, Dragan Y, Shinozawa T, Takebe T

Nature medicine　Vol. 26　No. 10　p. 1541-1548　2020/10

High-Fidelity Drug-Induced Liver Injury Screen Using Human Pluripotent Stem Cell-Derived Organoids.

Shinozawa T, Kimura M, Cai Y, Saiki N, Yoneyama Y, Ouchi R, Koike H, Maezawa M, Zhang RR, Dunn A, Ferguson A, Togo S, Lewis K, Thompson W, Asai A, Takebe T

Gastroenterology　2020/10

Generation of human induced pluripotent stem cell-derived liver buds with chemically defined and animal origin-free media.

Sekine K, Ogawa S, Tsuzuki S, Kobayashi T, Ikeda K, Nakanishi N, Takeuchi K, Kanai E, Otake Y, Okamoto S, Kobayashi T, Takebe T, Taniguchi H

Scientific reports　Vol. 10　No. 1　p. 17937-17937　2020/10　Research paper (scientific journal)

Stiffness distribution analysis in indentation depth direction reveals clear mechanical features of cells and organoids by using AFM

Kobayashi Naritaka, Togo Shodai, Matsuzaki Takahisa, Hashiseko Kaede, Kawamura Ryuzo, Suganuma Masami, Nakabayashi Seiichiro, Yoneyama Yosuke, Ouchi Rie, Takebe Takanori, Yoshikawa, Hiroshi Y

APPLIED PHYSICS EXPRESS　Vol. 13　No. 9　p. 097001-097001　2020/09　Research paper (scientific journal)

Orthotopic foetal lung tissue direct injection into lung showed a preventive effect against paraquat-induced acute lung injury in mice.

Okabe R, Chen-Yoshikawa TF, Yoshizawa A, Hirashima T, Saito M, Date H, Takebe T

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery　Vol. 58　No. 3　p. 638-645　2020/09　Research paper (scientific journal)

膜流動性revisited 細胞膜流動性と器官原基の自己組織化

松崎 賢寿, 武部 貴則, 吉川 洋史

脂質生化学研究　Vol. 62　p. 35-39　2020/05

Generation of multi-cellular human liver organoids from pluripotent stem cells.

Thompson WL, Takebe T

Methods in cell biology　Vol. 159　p. 47-68　2020

Organoid Medicine in Hepatology.

Sakabe K, Takebe T, Asai A

Clinical liver disease　Vol. 15　No. 1　p. 3-8　2020/01

The β-catenin/YAP signaling axis is a key regulator of melanoma-associated fibroblasts.

Liu T, Zhou L, Yang K, Iwasawa K, Kadekaro AL, Takebe T, Andl T, Zhang Y

Signal transduction and targeted therapy　Vol. 4　2019/12

De Novo-Designed Near-Infrared Nanoaggregates for Super-Resolution Monitoring of Lysosomes in Cells, in Whole Organoids, and in Vivo.

Fang H, Yao S, Chen Q, Liu C, Cai Y, Geng S, Bai Y, Tian Z, Zacharias AL, Takebe T, Chen Y, Guo Z, He W, Diao J

ACS nano　Vol. 13　No. 12　p. 14426-14436　2019/12

Generation of hepato-biliary-pancreatic organoid from human pluripotent stem cells

Hiroyuki Koike, Kentaro Iwasawa, Takanori Takebe

2019/11/11

The effect of contact needle therapy on fatigue in patients with cancer in palliative care: A study protocol for a randomized controlled trial.

Ogawa-Ochiai K, Yoshimura K, Takebe T, Iwahashi M, Shirai A, Tsuda M, Ogawa M, Ishikawa H

Medicine　Vol. 98　No. 44　2019/11　Research paper (scientific journal)

Modelling human hepato-biliary-pancreatic organogenesis from the foregut-midgut boundary.

Hiroyuki Koike, Kentaro Iwasawa, Rie Ouchi, Mari Maezawa, Kirsten Giesbrecht, Norikazu Saiki, Autumn Ferguson, Masaki Kimura, Wendy L Thompson, James M Wells, Aaron M Zorn, Takanori Takebe

Nature　Vol. 574　No. 7776　p. 112-116　2019/10　Research paper (scientific journal)

Modeling Steatohepatitis in Humans with Pluripotent Stem Cell-Derived Organoids.

Rie Ouchi, Shodai Togo, Masaki Kimura, Tadahiro Shinozawa, Masaru Koido, Hiroyuki Koike, Wendy Thompson, Rebekah A Karns, Christopher N Mayhew, Patrick S McGrath, Heather A McCauley, Ran-Ran Zhang, Kyle Lewis, Shoyo Hakozaki, Autumn Ferguson, Norikazu Saiki, Yosuke Yoneyama, Ichiro Takeuchi, Yo Mabuchi, Chihiro Akazawa, Hiroshi Y Yoshikawa, James M Wells, Takanori Takebe

Cell metabolism　Vol. 30　No. 2　p. 374-384　2019/08/06　Research paper (scientific journal)

Organoids by design.

Takebe T, Wells JM

Science (New York, N.Y.)　Vol. 364　No. 6444　p. 956-959　2019/06

Creativity for a cure.

Takebe T

Nature medicine　Vol. 25　No. 6　2019/06

Orthotopic Implantation with Immature Mouse Fetal Lung Did Not Self-Organize Airways Structures, but Improved Prognosis of Mice with Paraquat-Induced Severe Lung Injury

Okabe R, Chen-Yoshikawa T, Yoshizawa A, Hirashima T, Gochi F, Yamagishi H, Takahagi A, Saito M, Ohsumi A, Nakajima D, Hamaji M, Date H, Takebe T

JOURNAL OF HEART AND LUNG TRANSPLANTATION　Vol. 38　No. 4　p. S257-S257　2019/04

Defining Lineage-Specific Membrane Fluidity Signatures that Regulate Adhesion Kinetics.

Takahisa Matsuzaki, Shinya Matsumoto, Toshiharu Kasai, Emi Yoshizawa, Satoshi Okamoto, Hiroshi Y Yoshikawa, Hideki Taniguchi, Takanori Takebe

Stem cell reports　Vol. 11　No. 4　p. 852-860　2018/10/09

Truncating Mutation of Bsep/ABCB11 in Human Hepatocytes Derived from Induced Pluripotent Stem Cells Increases Their Susceptibility to Bile Acid Injury

Asai Akihiro, Hayashi Hisamitsu, Ibrahim Leena, Ssakabe Kokoro, Brandser Nicholas Ryan, Ishii Ken, Takebe Takanori, Aihara Eitaro

HEPATOLOGY　Vol. 68　p. 83A-84A　2018/10

Recapitulation of hepatitis B virus-host interactions in liver organoids from human induced pluripotent stem cells.

Yun-Zhong Nie, Yun-Wen Zheng, Kei Miyakawa, Soichiro Murata, Ran-Ran Zhang, Keisuke Sekine, Yasuharu Ueno, Takanori Takebe, Takaji Wakita, Akihide Ryo, Hideki Taniguchi

EBioMedicine　Vol. 35　p. 114-123　2018/09　Research paper (scientific journal)

Optimal Hypoxia Regulates Human iPSC-Derived Liver Bud Differentiation through Intercellular TGFB Signaling.

Ayabe H, Anada T, Kamoya T, Sato T, Kimura M, Yoshizawa E, Kikuchi S, Ueno Y, Sekine K, Camp JG, Treutlein B, Ferguson A, Suzuki O, Takebe T, Taniguchi H

STEM CELL REPORTS　Vol. 11　No. 2　p. 306-316　2018/08　Research paper (scientific journal)

Digitalized Human Organoid for Wireless Phenotyping.

Kimura, M, Azuma, M, Zhang, R. -R, Thompson, W, Mayhew, C. N, Takebe, T

iScience　Vol. 4　p. 294-301　2018/07

Organoid Center Strategies for Accelerating Clinical Translation

Takanori Takebe, James M. Wells, Michael A. Helmrath, Aaron M. Zorn

Cell Stem Cell　Vol. 22　No. 6　p. 806-809　2018/06/01

Illustrating the potency of current Good Manufacturing Practice–compliant induced pluripotent stem cell lines as a source of multiple cell lineages using standardized protocols

Mahendra S. Rao, Ying Pei, Thelma Y. Garcia, Shereen Chew, Toshiharu Kasai, Tomoko Hisai, Hideki Taniguchi, Takanori Takebe, Deepak A. Lamba, Xianmin Zeng

Cytotherapy　Vol. 20　No. 6　p. 861-872　2018/06/01　Research paper (scientific journal)

Self-Condensation Culture Enables Vascularization of Tissue Fragments for Efficient Therapeutic Transplantation

Yoshinobu Takahashi, Keisuke Sekine, Tatsuya Kin, Takanori Takebe, Hideki Taniguchi

Cell Reports　Vol. 23　No. 6　p. 1620-1629　2018/05/08　Research paper (scientific journal)

Methods for Generating Vascularized Islet-Like Organoids Via Self-Condensation.

Takahashi Y, Takebe T, Taniguchi H

Current protocols in stem cell biology　Vol. 45　No. 1　2018/05

Human iPSC-Derived Posterior Gut Progenitors Are Expandable and Capable of Forming Gut and Liver Organoids

Ran-Ran Zhang, Masaru Koido, Tomomi Tadokoro, Rie Ouchi, Tatsuya Matsuno, Yasuharu Ueno, Keisuke Sekine, Takanori Takebe, Hideki Taniguchi

Stem Cell Reports　Vol. 10　No. 3　p. 780-793　2018/03/13　Research paper (scientific journal)

Tumoroid à la carte: Path for personalization.

Lewis K, Takebe T

Hepatology (Baltimore, Md.)　2018/02

Massive and Reproducible Production of Liver Buds Entirely from Human Pluripotent Stem Cells

Takanori Takebe, Keisuke Sekine, Masaki Kimura, Emi Yoshizawa, Satoru Ayano, Masaru Koido, Shizuka Funayama, Noriko Nakanishi, Tomoko Hisai, Tatsuya Kobayashi, Toshiharu Kasai, Rina Kitada, Akira Mori, Hiroaki Ayabe, Yoko Ejiri, Naoki Amimoto, Yosuke Yamazaki, Shimpei Ogawa, Momotaro Ishikawa, Yasujiro Kiyota, Yasuhiko Sato, Kohei Nozawa, Satoshi Okamoto, Yasuharu Ueno, Hideki Taniguchi

CELL REPORTS　Vol. 21　No. 10　p. 2661-2670　2017/12　Research paper (scientific journal)

Synergistic Engineering: Organoids Meet Organs-on-a-Chip

Takanori Takebe, Boyang Zhang, Milica Radisic

CELL STEM CELL　Vol. 21　No. 3　p. 297-300　2017/09

Human Liver Bud Organoid Models Development

Takebe Takanori, Sekine Keisuke, Camp Gray, Treutlein Barbara

CELL SYSTEMS　Vol. 5　No. 1　p. 2-2　2017/07

Multilineage communication regulates human liver bud development from pluripotency

J. Gray Camp, Keisuke Sekine, Tobias Gerber, Henry Loeffler-Wirth, Hans Binder, Malgorzata Gac, Sabina Kanton, Jorge Kageyama, Georg Damm, Daniel Seehofer, Lenka Belicova, Marc Bickle, Rico Barsacchi, Ryo Okuda, Emi Yoshizawa, Masaki Kimura, Hiroaki Ayabe, Hideki Taniguchi, Takanori Takebe, Barbara Treutlein

NATURE　Vol. 546　No. 7659　p. 533-+　2017/06　Research paper (scientific journal)

Viability and Functional Assessment of Murine Pancreatic Islets After Transportation Between Korea and Japan (vol 47, pg 738, 2015)

S. Lee, Y. Takahashi, K. M. Lee, M. Mizuno, J. G. Nemeno, T. Takebe, J. I. Lee

TRANSPLANTATION PROCEEDINGS　Vol. 49　No. 3　p. 616-616　2017/04

Paracrine signals regulate human liver organoid maturation from induced pluripotent stem cells

Akihiro Asai, Eitaro Aihara, Carey Watson, Reena Mourya, Tatsuki Mizuochi, Pranavkumar Shivakumar, Kieran Phelan, Christopher Mayhew, Michael Helmrath, Takanori Takebe, James Wells, Jorge A. Bezerra

DEVELOPMENT　Vol. 144　No. 6　p. 1056-1064　2017/03　Research paper (scientific journal)

Nutritional modulation of mouse and human liver bud growth through a branched-chain amino acid metabolism

Hiroyuki Koike, Ran-Ran Zhang, Yasuharu Ueno, Keisuke Sekine, Yun-Wen Zheng, Takanori Takebe, Hideki Taniguchi

DEVELOPMENT　Vol. 144　No. 6　p. 1018-1024　2017/03　Research paper (scientific journal)

Mechanical characterization system using on-chip probe with wide range actuation

Keitaro Ito, Shinya Sakuma, Masaki Kimura, Takanori Takebe, Makoto Kaneko, Fumihito Arai

2016 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2016　2017/01/18　Research paper (international conference proceedings)

Liver regeneration using cultured liver bud

Keisuke Sekine, Takanori Takebe, Hideki Taniguchi

Methods in Molecular Biology　Vol. 1597　p. 207-216　2017　Part of collection (book)

Reverse engineering liver buds through self-driven condensation and organization towards medical application.

Tadahiro Shinozawa, Hiroshi Y Yoshikawa, Takanori Takebe

Developmental biology　Vol. 420　No. 2　p. 221-229　2016/12/15

Temporal Transition of Mechanical Characteristics of HUVEC/MSC Spheroids Using a Microfluidic Chip with Force Sensor Probes

Keitaro Ito, Shinya Sakuma, Masaki Kimura, Takanori Takebe, Makoto Kaneko, Fumihito Arai

MICROMACHINES　Vol. 7　No. 12　2016/12　Research paper (scientific journal)

Generating Mini-Organs in Culture.

Koike, H, Takebe, T

Current Pathobiology Reports　Vol. 4　No. 2　p. 59-68　2016/06

Engineering pancreatic tissues from stem cells towards therapy

Yoshinobu Takahashi, Takanori Takebe, Hideki Taniguchi

REGENERATIVE THERAPY　Vol. 3　p. 15-23　2016/03

Engineering pancreatic tissues from stem cells towards therapy

Yoshinobu Takahashi, Takanori Takebe, Hideki Taniguchi

REGENERATIVE THERAPY　Vol. 3　p. 15-23　2016/03

Stiffness-index map based on single cell-spheroid analysis using robot integrated microfluidic chiip

Keitaro Ito, Shinya Sakuma, Masaki Kimura, Takanori Takebe, Makoto Kaneko, Fumihito Arai

Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)　Vol. 2016-　p. 157-160　2016/02/26　Research paper (international conference proceedings)

Autotransplantation of monkey ear perichondrium-derived progenitor cells for cartilage reconstruction

Shintaro Kagimoto, Takanori Takebe, Shinji Kobayashi, Yuichiro Yabuki, Ayaka Hori, Koichi Hirotomi, Taro Mikami, Toshimasa Uemura, Jiro Maegawa, Hideki Taniguchi

Cell Transplantation　Vol. 25　No. 5　p. 951-962　2016　Research paper (scientific journal)

STIFFNESS-INDEX MAP BASED ON SINGLE CELL-SPHEROID ANALYSIS USING ROBOT INTEGRATED MICROFLUIDIC CHIIP.

Ito, K, Sakuma, S, Kimura, M, Takebe, T, Kaneko, M, Arai, F

CELL TRANSPLANTATION　Vol. 25　No. 5　p. 951-962　2016/01

Hepatic maturation of induced Pluripotent Stem Cells is regulated by paracrine signals from endothelial and mesenchymal stem cells in culture and during organoid formation

Akihiro Asai, Eitaro Aihara, Tatsuki Mizuochi, Kieran Phelan, Christopher Mayhew, Pranavkumar Shivakumar, Takanori Takebe, James Wells, Jorge A. Bezerra

HEPATOLOGY　Vol. 62　p. 544A-544A　2015/10

Vascularized and Complex Organ Buds from Diverse Tissues via Mesenchymal Cell-Driven Condensation

Takanori Takebe, Masahiro Enomura, Emi Yoshizawa, Masaki Kimura, Hiroyuki Koike, Yasuharu Ueno, Takahisa Matsuzaki, Takashi Yamazaki, Takafumi Toyohara, Kenji Osafune, Hiromitsu Nakauchi, Hiroshi Y. Yoshikawa, Hideki Taniguchi

CELL STEM CELL　Vol. 16　No. 5　p. 556-565　2015/05　Research paper (scientific journal)

Viability and Functional Assessment of Murine Pancreatic Islets After Transportation Between Korea and Japan

S. Lee, Y. Takahashi, K. M. Lee, M. Mizuno, J. G. Nemeno, T. Takebe, J. I. Lee

TRANSPLANTATION PROCEEDINGS　Vol. 47　No. 3　p. 738-741　2015/04　Research paper (scientific journal)

血管の分化と再生における最近の進歩 iPSC臓器芽移植療法の実現(Recent progress in differentiation and regeneration of vessels Realization of iPSC-organ bud transplantation therapy)

Takebe Takanori, Taniguchi Hideki

The Journal of Physiological Sciences　Vol. 65　No. Suppl.1　p. S50-S50　2015/03

Generation of functional human organ from pluripotent stem cell

Hideki Taniguchi, Takanori Takebe

MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences　p. 332-333　2015　Research paper (international conference proceedings)

Generation of functional human organs from pluripotent stem cells.

TANIGUCHI, H, TAKEBE, T

Japanese Journal of Transplantation　Vol. 50　No. 1　p. 24-30　2015/01

The visualization of human organogenesis from stem cells by recapitulating multicellular interactions

Ran-Ran Zhang, Hiroyuki Koike, Takanori Takebe

Hyper Bio Assembler for 3D Cellular Systems　p. 275-283　2015/01/01　Part of collection (book)

Novel strategies for liver therapy using stem cells

Tamir Rashid, Takanori Takebe, Hiromitsu Nakauchi

GUT　Vol. 64　No. 1　p. 1-4　2015/01　Research paper (scientific journal)

The effect of spine postures on the hydrodynamic drag in Epinephelus ongus larvae

Y. Kawabata, G. N. Nishihara, T. Yamaguchi, T. Takebe, K. Teruya, T. Sato, K. Soyano

JOURNAL OF FISH BIOLOGY　Vol. 85　No. 5　p. 1757-1765　2014/11　Research paper (scientific journal)

Transient vascularization of transplanted human adult-derived progenitors promotes self-organizing cartilage

Takanori Takebe, Shinji Kobayashi, Hiromu Suzuki, Mitsuru Mizuno, Yu-Min Chang, Emi Yoshizawa, Masaki Kimura, Ayaka Hori, Jun Asano, Jiro Maegawa, Hideki Taniguchi

JOURNAL OF CLINICAL INVESTIGATION　Vol. 124　No. 10　p. 4325-4334　2014/10　Research paper (scientific journal)

The CD133(+)CD44(+) Precancerous Subpopulation of Oval Cells Is a Therapeutic Target for Hepatocellular Carcinoma

Yun-Wen Zheng, Tomonori Tsuchida, Taiki Shimao, Bin Li, Takanori Takebe, Ran-Ran Zhang, Yu Sakurai, Yasuharu Ueno, Keisuke Sekine, Naoto Ishibashi, Makiko Imajima, Takuji Tanaka, Hideki Taniguchi

STEM CELLS AND DEVELOPMENT　Vol. 23　No. 18　p. 2237-2249　2014/09　Research paper (scientific journal)

Human iPSC-Derived Miniature Organs: A Tool for Drug Studies

T. Takebe, H. Taniguchi

CLINICAL PHARMACOLOGY & THERAPEUTICS　Vol. 96　No. 3　p. 310-313　2014/09　Research paper (scientific journal)

Polycomb Group Protein Ezh2 Regulates Hepatic Progenitor Cell Proliferation and Differentiation in Murine Embryonic Liver

Hiroyuki Koike, Rie Ouchi, Yasuharu Ueno, Susumu Nakata, Yuta Obana, Keisuke Sekine, Yun-Wen Zheng, Takanori Takebe, Kyoichi Isono, Haruhiko Koseki, Hideki Taniguchi

PLOS ONE　Vol. 9　No. 8　2014/08　Research paper (scientific journal)

Ring1B Promotes Hepatic Stem/Progenitor Cell Expansion Through Simultaneous Suppression of Cdkn1a and Cdkn2a in Mice

Hiroyuki Koike, Yasuharu Ueno, Takako Naito, Tomoya Shiina, Susumu Nakata, Rie Ouchi, Yuta Obana, Keisuke Sekine, Yun-Wen Zheng, Takanori Takebe, Kyo-ichi Isono, Haruhiko Koseki, Hideki Taniguchi

HEPATOLOGY　Vol. 60　No. 1　p. 323-333　2014/07　Research paper (scientific journal)

Tropism of Cancer Stem Cells to a Specific Distant Organ

Ryo Okuda, Keisuke Sekine, Daisuice Hisamatsu, Yasuharu Ueno, Takanori Takebe, Yun-Wen Zheng, Hideki Taniguchi

IN VIVO　Vol. 28　No. 3　p. 361-365　2014/05　Research paper (scientific journal)

The Development of Humanized Liver With Rag1 Knockout Rats

T. Tsuchida, Y. -W. Zheng, R. -R. Zhang, T. Takebe, Y. Ueno, K. Sekine, H. Taniguchi

TRANSPLANTATION PROCEEDINGS　Vol. 46　No. 4　p. 1191-1193　2014/05　Research paper (scientific journal)

Self-Formation of Vascularized Hepatic Tissue From Human Adult Hepatocyte

Y. Enomoto, M. Enomura, T. Takebe, Y. Mitsuhashi, M. Kimura, E. Yoshizawa, H. Taniguchi

TRANSPLANTATION PROCEEDINGS　Vol. 46　No. 4　p. 1243-1246　2014/05　Research paper (scientific journal)

Identification of Proliferating Human Hepatic Cells From Human Induced Pluripotent Stem Cells

R. Zhang, T. Takebe, K. Sekine, H. Koike, Y. Zheng, H. Taniguchi

TRANSPLANTATION PROCEEDINGS　Vol. 46　No. 4　p. 1201-1204　2014/05　Research paper (scientific journal)

High-Resolution Intravital Imaging for Monitoring the Transplanted Islets in Mice

Y. Takahashi, T. Takebe, M. Enomura, N. Koike, S. Lee, J. G. Nemeno, K. Sekine, J. I. Lee, H. Taniguchi

TRANSPLANTATION PROCEEDINGS　Vol. 46　No. 4　p. 1166-1168　2014/05　Research paper (scientific journal)

Fluorescent Labeling and Visualization of Human Induced Pluripotent Stem Cells With the Use of Transcription Activator-like Effector Nucleases

K. Sekine, T. Takebe, H. Taniguchi

TRANSPLANTATION PROCEEDINGS　Vol. 46　No. 4　p. 1205-1207　2014/05　Research paper (scientific journal)

Evidence of a Sophisticatedly Heterogeneous Population of Human Umbilical Vein Endothelial Cells

Y. -W. Zheng, Y. -Z. Nie, T. Tsuchida, R. -R. Zhang, K. Aoki, K. Sekine, M. Ogawa, T. Takebe, Y. Ueno, H. Sakakibara, F. Hirahara, H. Taniguchi

TRANSPLANTATION PROCEEDINGS　Vol. 46　No. 4　p. 1251-1253　2014/05　Research paper (scientific journal)

Elastic Cartilage Reconstruction by Transplantation of Cultured Hyaline Cartilage-Derived Chondrocytes

M. Mizuno, T. Takebe, S. Kobayashi, S. Kinnura, M. Masutani, S. Lee, Y. H. Jo, Ji Lee, H. Taniguchi

TRANSPLANTATION PROCEEDINGS　Vol. 46　No. 4　p. 1217-1221　2014/05　Research paper (scientific journal)

Effects of Natural Cartilaginous Extracellular Matrix on Chondrogenic Potential for Cartilage Cell Transplantation

W. Yang, S. Lee, Y. H. Jo, K. M. Lee, J. G. Nemeno, B. M. Nam, B. Y. Kim, I. J. Jang, H. N. Kim, T. Takebe, J. I. Lee

TRANSPLANTATION PROCEEDINGS　Vol. 46　No. 4　p. 1247-1250　2014/05　Research paper (scientific journal)

Effect of Preservation Conditions on Cartilage Tissue for Cell Transplantation

B. Y. Kim, B. M. Nam, K. M. Lee, Y. H. Jo, J. G. Nemeno, W. Yang, S. Lee, H. Kim, I. J. Jang, T. Takebe, J. I. Lee

TRANSPLANTATION PROCEEDINGS　Vol. 46　No. 4　p. 1139-1144　2014/05　Research paper (scientific journal)

Effect of Cryopreservation and Cell Passage Number on Cell Preparations Destined for Autologous Chondrocyte Transplantation

B. M. Nam, B. Y. Kim, Y. H. Jo, S. Lee, J. G. Nemeno, W. Yang, K. M. Lee, H. Kim, I. J. Jang, T. Takebe, J. I. Lee

TRANSPLANTATION PROCEEDINGS　Vol. 46　No. 4　p. 1145-1149　2014/05　Research paper (scientific journal)

Artificial Islets From Hybrid Spheroids of Three Pancreatic Cell Lines

Y. H. Jo, I. J. Jang, J. G. Nemeno, S. Lee, B. Y. Kim, B. M. Nam, W. Yang, K. M. Lee, H. Kim, T. Takebe, Y. S. Kim, J. I. Lee

TRANSPLANTATION PROCEEDINGS　Vol. 46　No. 4　p. 1156-1160　2014/05　Research paper (scientific journal)

Engineering of human hepatic tissue with functional vascular networks

Takanori Takebe, Naoto Koike, Keisuke Sekine, Ryoji Fujiwara, Takeru Amiya, Yun-Wen Zheng, Hideki Taniguchi

ORGANOGENESIS　Vol. 10　No. 2　p. 260-267　2014/04　Research paper (scientific journal)

Brief Report: Reconstruction of Joint Hyaline Cartilage by Autologous Progenitor Cells Derived from Ear Elastic Cartilage

Mitsuru Mizuno, Shinji Kobayashi, Takanori Takebe, Hiroomi Kan, Yuichiro Yabuki, Takahisa Matsuzaki, Hiroshi Y. Yoshikawa, Seiichiro Nakabayashi, Lee Jeong Ik, Jiro Maegawa, Hideki Taniguchi

STEM CELLS　Vol. 32　No. 3　p. 816-821　2014/03　Research paper (scientific journal)

Generation of a vascularized and functional human liver from an iPSC-derived organ bud transplant

Takanori Takebe, Ran-Ran Zhang, Hiroyuki Koike, Masaki Kimura, Emi Yoshizawa, Masahiro Enomura, Naoto Koike, Keisuke Sekine, Hideki Taniguchi

NATURE PROTOCOLS　Vol. 9　No. 2　p. 396-409　2014/02　Research paper (scientific journal)

Efficient generation of mature hepatocyte-like cells from human iPSCs

Hinatsu Ohgane, Takanori Takebe, Keisuke Sekine, Hideki Taniguchi

2014 INTERNATIONAL SYMPOSIUM ON MICRO-NANOMECHATRONICS AND HUMAN SCIENCE (MHS)　2014　Research paper (international conference proceedings)

Efficient hepatic differentiation of human induced pluripotent stem cells in a three-dimensional microscale culture.

Ran-Ran Zhang, Takanori Takebe, Leina Miyazaki, Maho Takayama, Hiroyuki Koike, Masaki Kimura, Masahiro Enomura, Yun-Wen Zheng, Keisuke Sekine, Hideki Taniguchi

Methods in molecular biology (Clifton, N.J.)　Vol. 1210　p. 131-41　2014　Research paper (scientific journal)

Vascularized and functional liver devided from human induced pluripotent stem cells by recapitulating organogenesis.

Takebe, T, Taniguchi, H

Yokohama Medical Journal　Vol. 65　No. 4　p. 503-507　2014/01

Vascularized and functional human liver from an iPSC-derived organ bud transplant

Takanori Takebe, Keisuke Sekine, Masahiro Enomura, Hiroyuki Koike, Masaki Kimura, Takunori Ogaeri, Ran-Ran Zhang, Yasuharu Ueno, Yun-Wen Zheng, Naoto Koike, Shinsuke Aoyama, Yasuhisa Adachi, Hideki Taniguchi

NATURE　Vol. 499　No. 7459　p. 481-+　2013/07　Research paper (scientific journal)

The generation of pancreatic β-cell spheroids in a simulated microgravity culture system

Hiroyasu Tanaka, Shin Tanaka, Keisuke Sekine, Sayaka Kita, Ai Okamura, Takanori Takebe, Yun-Wen Zheng, Yasuharu Ueno, Junzo Tanaka, Hideki Taniguchi

Biomaterials　Vol. 34　No. 23　p. 5785-5791　2013/07　Research paper (scientific journal)

Establishment of automated culture system for murine induced pluripotent stem cells

Hiroyuki Koike, Koji Kubota, Keisuke Sekine, Takanori Takebe, Rie Ouchi, Yun-Wen Zheng, Yasuharu Ueno, Naoki Tanigawa, Hideki Taniguchi

BMC BIOTECHNOLOGY　Vol. 12　2012/11　Research paper (scientific journal)

Self-Organization of Human Hepatic Organoid by Recapitulating Organogenesis In Vitro

T. Takebe, K. Sekine, Y. Suzuki, M. Enomura, S. Tanaka, Y. Ueno, Y. -W. Zheng, H. Taniguchi

TRANSPLANTATION PROCEEDINGS　Vol. 44　No. 4　p. 1018-1020　2012/05　Research paper (scientific journal)

Regenerative Medicine Approach as an Alternative Treatment to Islet Transplantation

K. Sekine, T. Takebe, M. Enomura, C. Matsui, H. Tanaka, H. Taniguchi

TRANSPLANTATION PROCEEDINGS　Vol. 44　No. 4　p. 1104-1106　2012/05　Research paper (scientific journal)

Human Elastic Cartilage Engineering from Cartilage Progenitor Cells Using Rotating Wall Vessel Bioreactor

T. Takebe, S. Kobayashi, H. Kan, H. Suzuki, Y. Yabuki, M. Mizuno, T. Adegawa, T. Yoshioka, J. Tanaka, J. Maegawa, H. Taniguchi

TRANSPLANTATION PROCEEDINGS　Vol. 44　No. 4　p. 1158-1161　2012/05　Research paper (scientific journal)

Highly Efficient Generation of Definitive Endoderm Lineage from Human Induced Pluripotent Stem Cells

K. Sekine, T. Takebe, Y. Suzuki, A. Kamiya, H. Nakauchi, H. Taniguchi

TRANSPLANTATION PROCEEDINGS　Vol. 44　No. 4　p. 1127-1129　2012/05　Research paper (scientific journal)

Generation of Functional Human Vascular Network

T. Takebe, N. Koike, K. Sekine, M. Enomura, Y. Chiba, Y. Ueno, Y. -W. Zheng, H. Taniguchi

TRANSPLANTATION PROCEEDINGS　Vol. 44　No. 4　p. 1130-1133　2012/05　Research paper (scientific journal)

An h-dependent formulation of the Kadomtsev-Petviashvili hierarchy

K. Takasaki, T. Takebe

THEORETICAL AND MATHEMATICAL PHYSICS　Vol. 171　No. 2　p. 683-690　2012/05　Research paper (scientific journal)

Presence of Cartilage Stem/Progenitor Cells in Adult Mice Auricular Perichondrium

Shinji Kobayashi, Takanori Takebe, Yun-Wen Zheng, Mitsuru Mizuno, Yuichiro Yabuki, Jiro Maegawa, Hideki Taniguchi

PLOS ONE　Vol. 6　No. 10　2011/10　Research paper (scientific journal)

Reconstruction of human elastic cartilage by a CD44(+) CD90(+) stem cell in the ear perichondrium

Shinji Kobayashi, Takanori Takebe, Midori Inui, Sayaka Iwai, Hiroomi Kan, Yun-Wen Zheng, Jiro Maegawa, Hideki Taniguchi

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　Vol. 108　No. 35　p. 14479-14484　2011/08　Research paper (scientific journal)