A Photoactivatable Antagonist for Controlling CREB Dependent Gene Expression

T. Imoto, M. Minoshima, T. Yokoyama, B. P. Emery, S. D. Bull, H. Bito, K. Kikuchi

ACS Cent. Sci.　Vol. 6　No. 10　p. 1813-1818　2020/08　Research paper (scientific journal)

Rapid No-wash Labeling of PYP-tag Proteins with Reactive Fluorogenic Ligands Affords Stable Fluorescent Protein Conjugates for Long-Term Cell Imaging Studies

N. Kumar, Y. Hori, M. Nishiura, K. Kikuchi

Chem. Sci.　Vol. 2020　No. 11　p. 3694-3701　2020/05　Research paper (scientific journal)

No-wash fluorogenic labeling of proteins for reversible photoswitching in live cells

Kenji Torii, Sam Benson, Yuichiro Hori, Marc Vendrell, Kazuya Kikuchi

Chemical Science　Vol. 15　p. 1393-1401　2024/12　Research paper (scientific journal)

Light‐Activated Gene Expression System Using a Caging‐Group‐Free Photoactivatable Dye

Tatsuki Nonomura, Masafumi Minoshima, Kazuya Kikuchi

Angewandte Chemie International Edition　2024/10/23　Research paper (scientific journal)

Development of elliptic core-shell nanoparticles with fluorinated surfactants for 19F MRI

Yue Wu, Masafumi Minoshima, Kazuya Kikuchi

Frontiers in Chemistry　Vol. 12　2024/06/12　Research paper (scientific journal)

Hybrid Small-Molecule/Protein Fluorescent Probes

Masafumi Minoshima, Shahi Imam Reja, Ryu Hashimoto, Kohei Iijima, Kazuya Kikuchi

Chemical Reviews　Vol. 124　No. 10　p. 6198-6270　2024/05/08　Research paper (scientific journal)

Recent advancements of fluorescent biosensors using semisynthetic probes

Shahi Imam Reja, Masafumi Minoshima, Yuichiro Hori, Kazuya Kikuchi

Biosensors and Bioelectronics　Vol. 247　p. 115862-115862　2024/03　Research paper (scientific journal)

Rational Design of Hydroxylated Thiazole Orange Photocages for Green Light‐Triggered DNA Recombination

Ryu Hashimoto, Masafumi Minoshima, Kazuya Kikuchi

ChemBioChem　Vol. 25　No. 4　2024/01/19　Research paper (scientific journal)

Activatable 19F MRI probe for detection of α-amylase activity

Yuki Konishi, Yuya Otera, Masafumi Minoshima, Kazuya Kikuchi

Chemistry Letters　Vol. 53　No. 1　2024/01/11　Research paper (scientific journal)

Bioisostere-conjugated fluorescent probes for live-cell protein imaging without non-specific organelle accumulation

Takuya Kamikawa, Akari Hashimoto, Nozomi Yamazaki, Junya Adachi, Ayami Matsushima, Kazuya Kikuchi, Yuichiro Hori

Chemical Science　Vol. 15　No. 21　p. 8097-8105　2024　Research paper (scientific journal)

Elastic Polymer Coated Nanoparticles with Fast Clearance for ¹⁹F MR Imaging

Yuki Konishi, Masafumi Minoshima, Kohei Fujihara, Takayuki Uchihashi, Kazuya Kikuchi

Angewandte Chemie International Edition　Vol. 62　2023/08/28　Research paper (scientific journal)

Persistent Fluorescence Switching of a Probe Using a Photochromic Quencher with High Photostability Assisted by Protein-Surface Modification

Kenji Torii, Yuichiro Hori, Kazuya Kikuchi

Analytical Chemistry　Vol. 95　No. 23　p. 8834-8841　2023/05/25　Research paper (scientific journal)

Long-term imaging of intranuclear Mg²⁺ dynamics during mitosis using a localized fluorescent probe

Yusuke Matsui, Toshiyuki Kowada, Yi Ding, Priya Ranjan Sahoo, Kazuya Kikuchi, Shin Mizukami

Chemical Communications　Vol. 59　No. 46　p. 7048-7051　2023/05　Research paper (scientific journal)

Visualization of multiple localizations of GLUT4 by fluorescent probes of PYP-tag with designed unnatural warhead

Miyako Nishiura, Yuichiro Hori, Maho Umeno, Kazuya Kikuchi

Chemical Science　Vol. 14　No. 22　p. 5925-5935　2023/05　Research paper (scientific journal)

Development of a Versatile Protein Labeling Tool for Live‐Cell Imaging Using Fluorescent β‐Lactamase Inhibitors

Masafumi Minoshima, Taro Umeno, Kohei Kadooka, Margaux Roux, Namiko Yamada, Kazuya Kikuchi

Angewandte Chemie International Edition　Vol. 62　No. 18　2023/03/27　Research paper (scientific journal)

JAK inhibition ameliorates bone destruction by simultaneously targeting mature osteoclasts and their precursors.

Shinya Yari, Junichi Kikuta, Hotaka Shigyo, Yu Miyamoto, Daisuke Okuzaki, Yuki Furusawa, Masafumi Minoshima, Kazuya Kikuchi, Masaru Ishii

Inflammation and regeneration　Vol. 43　No. 1　p. 18-18　2023/03/03　Research paper (scientific journal)

Hybrid, dual visible and near-infrared fluorescence emission of (6,5) Single-Walled Carbon Nanotubes modified with fluorescein through aryl diazonium salt chemistry

Mateusz Michał Tomczyk, Masafumi Minoshima, Kazuya Kikuchi, Agata Blacha-Grzechnik, Zbigniew Starosolski, Rohan Bhavane, Mariusz Zalewski, Nikodem Kuznik (Kuźnik)

Nanotechnology　2022/10/21　Research paper (scientific journal)

Recent advances in activatable 19F MR Imaging nano‐probes for the detection of biomarkers

Jeremy Salaam, Masafumi Minoshima, Kazuya Kikuchi

Analysis & Sensing　2022/10/07　Research paper (scientific journal)

Photoinitiator‐Free Two‐Photon Polymerization of Biocompatible Materials for 3D Micro/Nanofabrication

Atsushi Nakayama, Yasuaki Kumamoto, Masafumi Minoshima, Kazuya Kikuchi, Atsushi Taguchi, Katsumasa Fujita

Advanced Optical Materials　p. 2200474-2200474　2022/07　Research paper (scientific journal)

pH‐Sensitive Polymethacrylates as Potential Contrast Agents in ¹⁹ F MRI

Mariusz Zalewski, Dawid Janasik, Anna Kapała, Masafumi Minoshima, Fuminori Sugihara, Wojciech Raj, Joanna Pietrasik, Kazuya Kikuchi, Tomasz Krawczyk

Macromolecular Chemistry and Physics　Vol. 223　No. 14　p. 2200027-2200027　2022/07　Research paper (scientific journal)

Anti-Siglec-15 antibody suppresses bone resorption by inhibiting osteoclast multinucleation without attenuating bone formation

Hiroyuki Tsukazaki, Junichi Kikuta, Tomoka Ao, Akito Morimoto, Chie Fukuda, Eisuke Tsuda, Masafumi Minoshima, Kazuya Kikuchi, Takashi Kaito, Masaru Ishii

Bone　Vol. 152　p. 116095-116095　2021/11　Research paper (scientific journal)

Cardioluminescence in Transgenic Zebrafish Larvae: A Calcium Imaging Tool to Study Drug Effects and Pathological Modeling

Manuel Vicente, Jussep Salgado-Almario, Michelle M. Collins, Antonio Martínez-Sielva, Masafumi Minoshima, Kazuya Kikuchi, Beatriz Domingo, Juan Llopis

Biomedicines　Vol. 9　No. 10　p. 1294-1294　2021/09/22　Research paper (scientific journal)

Development of Off-On Switching ¹⁹F MRI Probes for Cathepsin K Activity Detection

Yuki Konishi, Atsuya Okunishi, Fuminori Sugihara, Tatsuya Nakamura, Kazuki Akazawa, Masafumi Minoshima, Kazuya Kikuchi

Bulletin of the Chemical Society of Japan　Vol. 94　p. 1690-1694　2021/04/27　Research paper (scientific journal)

A step towards gadolinium-free bioresponsive MRI contrast agent

Marzena Wyskocka-Gajda, Łukasz Przypis, Monika Olesiejuk, Tomasz Krawczyk, Anna Kuźnik, Krzysztof Nawara, Masafumi Minoshima, Fuminori Sugihara, Kazuya Kikuchi, Nikodem Kuźnik

European Journal of Medicinal Chemistry　Vol. 211　p. 113086-113086　2021/02　Research paper (scientific journal)

Single-cell dynamics of pannexin-1-facilitated programmed ATP loss during apoptosis

Hiromi Imamura, Shuichiro Sakamoto, Tomoki Yoshida, Yusuke Matsui, Silvia Penuela, Dale W Laird, Shin Mizukami, Kazuya Kikuchi, Akira Kakizuka

eLife　Vol. 9　2020/10/14　Research paper (scientific journal)

Oxygen Functional Groups on MWCNT Surface as Critical Factor Boosting T2 Relaxation Rate of Water Protons: Towards Improved CNT-Based Contrast Agents.

Tomczyk MM, Boncel S, Herman A, Krawczyk T, Jakóbik-Kolon A, Pawlyta M, Krzywiecki M, Chrobak A, Minoshima M, Sugihara F, Kikuchi K, Kuźnik N

Int J Nanomedicine.　Vol. 2020　No. 15　p. 7433-7450　2020/10　Research paper (scientific journal)

Development of photoswitchable fluorescent molecules using arylazopyrazole

K. Torii, Y. Hori, K. Watabe, K. Kikuchi

Bull. Chem. Soc. Jpn.　Vol. 93　No. 7　p. 821-824　2020/05　Research paper (scientific journal)

Direct visualization of an antidepressant analog using surface-enhanced Raman scattering in the brain

Masato Tanuma, Atsushi Kasai, Kazuki Bando, Naoyuki Kotoku, Kazuo Harada, Masafumi Minoshima, Kosuke Higashino, Atsushi Kimishima, Masayoshi Arai, Yukio Ago, Kaoru Seiriki, Kazuya Kikuchi, Satoshi Kawata, Katsumasa Fujita, Hitoshi Hashimoto

JCI Insight　Vol. 5　No. 6　2020/03/26　Research paper (scientific journal)

Sensing Peroxynitrite in Different Organelles of Murine RAW264.7 Macrophages With Coumarin-Based Fluorescent Probes

Maria Weber, Namiko Yamada, Xue Tian, Steven D. Bull, Masafumi Minoshima, Kazuya Kikuchi, Amanda B. Mackenzie, Tony D. James

Frontiers in Chemistry　Vol. 8　2020/02/20　Research paper (scientific journal)

Engineered Protein-Tag for Rapid Live-Cell Fluorogenic Visualization of Proteins by Anionic Probes

Jingchi Gao, Yuichiro Hori, Miyako Nishiura, Mathieu Bordy, Jens Hasserodt, Kazuya Kikuchi

Chem. Lett.　Vol. 49　No. 3　p. 232-235　2020/01　Research paper (scientific journal)

Live-Cell Imaging of Protein Degradation Utilizing Designed Protein-Tag Mutant and Fluorescent Probe with Turn-Off Switch

Jingchi Gao, Yuichiro Hori, Osamu Takeuchi, Kazuya Kikuchi

Bioconjugate Chem.　Vol. 31　No. 3　p. 577-583　2019/12　Research paper (scientific journal)

Improvement in Photostability of Fluorescein by Lanthanide Ions Based on Energy Transfer-based Triplet State Quenching

Takuma Imoto, Masayasu Muramatsu, Hiroshi Miyasaka, Shin Mizukami, Kazuya Kikuchi

Chemistry Letters　Vol. 48　No. 10　p. 1181-1184　2019/12　Research paper (scientific journal)

Photolytic Release of a Caged Inhibitor of an Endogenous Transcription Factor Enables Optochemical Control of CREB-Mediated Gene Expression

Takuma Imoto, Akihiro Kawase, Masafumi Minoshima, Tatsushi Yokoyama, Haruhiko Bito, Kazuya Kikuchi

Organic Letters　Vol. 22　No. 1　p. 22-25　2019/11/11　Research paper (scientific journal)

Development of Fluorogenic Probes for Rapid High‐Contrast Imaging of Transient Nuclear Localization of Sirtuin 3

Jingchi Gao, Yuichiro Hori, Takashi Shimomura, Mathieu Bordy, Jens Hasserodt, Kazuya Kikuchi

ChemBioChem　Vol. 21　No. 5　p. 656-662　2019/11/04　Research paper (scientific journal)

In vivo Multicolor Imaging with Fluorescent Probes Revealed the Dynamics and Function of Osteoclast Proton Pumps

Masafumi Minoshima, Junichi Kikuta, Yuta Omori, Shigeto Seno, Riko Suehara, Hiroki Maeda, Hideo Matsuda, Masaru Ishii, Kazuya Kikuchi

ACS Central Science　Vol. 5　No. 6　p. 1059-1066　2019/06　Research paper (scientific journal)

SCOTfluors: Small, Conjugatable, Orthogonal, and Tunable Fluorophores for In Vivo Imaging of Cell Metabolism

Sam Benson, Antonio Fernandez, Nicole D. Barth, Fabio de Moliner, Mathew H. Horrocks, C. Simon Herrington, Jose Luis Abad, Antonio Delgado, Lisa Kelly, Ziyuan Chang, Yi Feng, Miyako Nishiura, Yuichiro Hori, Kazuya Kikuchi, Marc Vendrell

Angewandte Chemie International Edition　Vol. 58　No. 21　p. 6911-6915　2019/05/20　Research paper (scientific journal)

Perfluorocarbon‐Based ¹⁹ F MRI Nanoprobes for In Vivo Multicolor Imaging

Kazuki Akazawa, Fuminori Sugihara, Tatsuya Nakamura, Hisashi Matsushita, Hiroaki Mukai, Rena Akimoto, Masafumi Minoshima, Shin Mizukami, Kazuya Kikuchi

Angewandte Chemie International Edition　Vol. 57　No. 51　p. 16742-16747　2018/12/17　Research paper (scientific journal)

Synthetic-Molecule/Protein Hybrid Probe with Fluorogenic Switch for Live-Cell Imaging of DNA Methylation

Yuichiro Hori, Norimichi Otomura, Ayuko Nishida, Miyako Nishiura, Maho Umeno, Isao Suetake, Kazuya Kikuchi

J. Am. Chem. Soc.,　Vol. 140　No. 5　p. 1686-1690　2018/12　Research paper (scientific journal)

Sensing caspase-1 activity using activatable 19F MRI nanoprobes with improved turn-on kinetics.

Kazuki Akazawa, Fuminori Sugihara, Masafumi Minoshima, Shin Mizukami, Kazuya Kikuchi

Chemical communications (Cambridge, England)　Vol. 54　No. 83　p. 11785-11788　2018/10　Research paper (scientific journal)

In vivo visualisation of different modes of action of biological DMARDs inhibiting osteoclastic bone resorption

Yoshinobu Matsuura, Junichi Kikuta, Yuika Kishi, Tetsuo Hasegawa, Daisuke Okuzaki, Toru Hirano, Masafumi Minoshima, Kazuya Kikuchi, Atsushi Kumanogoh, Masaru Ishii

ANNALS OF THE RHEUMATIC DISEASES　Vol. 77　No. 8　p. 1220-1226　2018/08　Research paper (scientific journal)

Dynamic Analyses of the Short-Term Effects of Different Bisphosphonates Using Intravital Two-Photon Microscopy.

Junichi Kikuta, Mai Shirazaki, Takao Sudo, Hiroki Mizuno, Akito Morimoto, Riko Suehara, Masafumi Minoshima, Kazuya Kikuchi, Masaru Ishii

JBMR plus　Vol. 2　No. 6　p. 362-366　2018/05　Research paper (scientific journal)

Highly Sensitive Detection of Caspase-3/7 Activity in Living Mice Using Enzyme-Responsive ¹⁹F MRI Nanoprobes

Kazuki Akazawa, Fuminori Sugihara, Tatsuya Nakamura, Shin Mizukami, Kazuya Kikuchi

Bioconjugate Chemistry　Vol. 29　No. 5　p. 1720-1728　2018/05/01　Research paper (scientific journal)

Direct cell–cell contact between mature osteoblasts and osteoclasts dynamically controls their functions in vivo

Masayuki Furuya, Junichi Kikuta, Sayumi Fujimori, Shigeto Seno, Hiroki Maeda, Mai Shirazaki, Maki Uenaka, Hiroki Mizuno, Yoriko Iwamoto, Akito Morimoto, Kunihiko Hashimoto, Takeshi Ito, Yukihiro Isogai, Masafumi Kashii, Takashi Kaito, Shinsuke Ohba, Ung-il Chung, Alexander C. Lichtler, Kazuya Kikuchi, Hideo Matsuda, Hideki Yoshikawa, Masaru Ishii

Nature Communications　Vol. 9　No. 1　2018/01/19　Research paper (scientific journal)

Ratiometric Imaging of Intracellular Mg²⁺ Dynamics Using a Red Fluorescent Turn-off Probe and a Green Fluorescent Turn-on Probe

Yusuke Matsui, Shin Mizukami, Kazuya Kikuchi

Chemistry Letters　Vol. 47　No. 1　p. 23-26　2018/01/05　Research paper (scientific journal)

Intracellular Protein-Labeling Probes for Multicolor Single-Molecule Imaging of Immune Receptor–Adaptor Molecular Dynamics

Ryota Sato, Jun Kozuka, Masahiro Ueda, Reiko Mishima, Yutaro Kumagai, Akimasa Yoshimura, Masafumi Minoshima, Shin Mizukami, Kazuya Kikuchi

Journal of the American Chemical Society　Vol. 139　No. 48　p. 17397-17404　2017/11/24　Research paper (scientific journal)

Visualization of Long-term Mg2+ Dynamics in Apoptotic Cells Using a Novel Targetable Fluorescent Probe

Y. Matsui, Y. Funato, H. Imamura, H. Miki, S. Mizukami, K. Kikuchi

Chem. Sci.　Vol. 8　No. 12　p. 8255-8264　2017/10　Research paper (scientific journal)

Development of Multicolor Fluorogenic Probes for Elucidating Role of GLUT4 N-Glycan in Intracellular Trafficking

Hori, Y. Hirayama, H, Benedek, Z, Suzuki, T, Kikuchi, K

2017/08　Research paper (international conference proceedings)

Highly selective tridentate fluorescent probes for visualizing intracellular Mg²⁺ dynamics without interference from Ca²⁺ fluctuation

Yusuke Matsui, Kalyan K. Sadhu, Shin Mizukami, Kazuya Kikuchi

Chemical Communications　Vol. 53　No. 77　p. 10644-10647　2017/08　Research paper (scientific journal)

Photostable and photoswitching fluorescent dyes for super-resolution imaging

Masafumi Minoshima, Kazuya Kikuchi

J. Biol. Inorg. Chem.　Vol. 22　p. 1-14　2017/07　Research paper (scientific journal)

Enzyme-triggered compound release using functionalized antimicrobial peptide derivatives (vol 8, pg 3047, 2017)

Shin Mizukami, Masayoshi Kashibe, Kengo Matsumoto, Yuichiro Hori, Kazuya Kikuchi

CHEMICAL SCIENCE　Vol. 8　No. 4　p. 3276-3276　2017/04　Research paper (scientific journal)

Development of Cyanine Probes with Dinitrobenzene Quencher for Rapid Fluorogenic Protein Labeling

Hori, Y, Hirayama, S, Kikuchi, K

Philos. Trans. R. Soc. London, Ser. A　Vol. 375　2017/04　Research paper (scientific journal)

Enzyme-triggered compound release using functionalized antimicrobial peptide derivatives

Shin Mizukami, Masayoshi Kashibe, Kengo Matsumoto, Yuichiro Hori, Kazuya Kikuchi

Chemical Science　Vol. 8　No. 4　p. 3047-3053　2017/01　Research paper (scientific journal)

Fluorogenic probes reveal a role of GLUT4 N-glycosylation in intracellular trafficking

Shinya Hirayama, Yuichiro Hori, Zsolt Benedek, Tadashi Suzuki, Kazuya Kikuchi

Nature Chemical Biology　Vol. 12　No. 10　p. 853-859　2016/08/22　Research paper (scientific journal)

Real-time intravital imaging of pH variation associated with osteoclast activity

Hiroki Maeda, Toshiyuki Kowada, Junichi Kikuta, Masayuki Furuya, Mai Shirazaki, Shin Mizukami, Masaru Ishii, Kazuya Kikuchi

Nature Chemical Biology　Vol. 12　No. 8　p. 579-585　2016/06/06　Research paper (scientific journal)

Modified polysaccharides as potential (19)F magnetic resonance contrast agents.

Tomasz Krawczyk, Masafumi Minoshima, Fuminori Sugihara, Kazuya Kikuchi

Carbohydrate research　Vol. 428　p. 72-78　2016/06　Research paper (scientific journal)

Fabrication of “Clickable” Polyfluorene Nanowires with High Aspect Ratio as Biological Sensing Platforms

Tuchinda Wasin, Kazuyuki Enomoto, Tsuneaki Sakurai, Vikas S. Padalkar, Hoi Lok Cheng, Michael T. Tang, Akifumi Horio, Daisuke Sakamaki, Masaaki Omichi, Akinori Saeki, Kazuya Kikuchi, Yuichiro Hori, Atsuya Chiba, Yuichi Saito, Tomihiro Kamiya, Masaki Sugimoto, Shu Seki

ACS Sensors　Vol. 1　No. 6　p. 766-774　2016/05/17　Research paper (scientific journal)

Chemical probes for fluorescence imaging in living mice

Toshiyuki Kowada, Hiroki Maeda, Kazuya Kikuchi

Optical Probes in Biology　p. 335-353　2016/04/19　Part of collection (book)

pH感受性蛍光プローブを用いた生体内破骨細胞活性リアルタイムイメージング

大森 雄太, 前田 拓樹, 小和田 俊行, 菊田 順一, 古家 雅之, 石井 優, 菊地 和也

JSMI Report　Vol. 9　No. 2　p. 134-134　2016/04　Research paper (scientific journal)

Selective Labeling of Proteins on Living Cell Membranes Using Fluorescent Nanodiamond Probes

Shingo Sotoma, Jun Iimura, Ryuji Igarashi, Koichiro Hirosawa, Hidenori Ohnishi, Shin Mizukami, Kazuya Kikuchi, Takahiro Fujiwara, Masahiro Shirakawa, Hidehito Tochio

Nanomaterials　Vol. 6　No. 4　p. 56-56　2016/03/25　Research paper (scientific journal)

Visualization and Functional Regulation of Live Cell Proteins Based on Labeling Probe Design

Mizukami Shin, Kikuchi Kazuya

YAKUGAKU ZASSHI　Vol. 136　No. 1　p. 21-27　2016　Research paper (scientific journal)

Design of a Protein Tag and Fluorogenic Probe with Modular Structure for Live-Cell Imaging of Intracellular Proteins

Kamikawa, Y, Hori, Y, Yamashita, K, Jin, L, Hirayama, S, Standley, D. M, Kikuchi, K

Chem. Sci.　Vol. 7　No. 1　p. 308-314　2016/01　Research paper (scientific journal)

Redesign of a Fluorogenic Labeling System To Improve Surface Charge, Brightness, and Binding Kinetics for Imaging the Functional Localization of Bromodomains

Hori Y, Hirayama S, Sato M, Kikuchi K

Angewandte Chemie International Edition　Vol. 54　No. 48　p. 14368-14371　2015/11　Research paper (scientific journal)

Nonlinear fluorescence probe using photoinduced charge separation

Kentaro Mochizuki, Lanting Shi, Shin Mizukami, Masahito Yamanaka, Mamoru Tanabe, Wei-Tao Gong, Almar F. Palonpon, Shogo Kawano, Satoshi Kawata, Kazuya Kikuchi, Katsumasa Fujita

NANOIMAGING AND NANOSPECTROSCOPY III　Vol. 9554　2015/10　Research paper (international conference proceedings)

An enzyme-responsive metal-enhanced near-infrared fluorescence sensor based on functionalized gold nanoparticles

Zhanghua Zeng, Shin Mizukami, Katsumasa Fujita, Kazuya Kikuchi

Chemical Science　Vol. 6　No. 8　p. 4934-4939　2015/06　Research paper (scientific journal)

Intramolecular Long-Distance Nucleophilic Reactions as a Rapid Fluorogenic Switch Applicable to the Detection of Enzymatic Activity

Reisuke Baba, Yuichiro Hori, Kazuya Kikuchi

CHEMISTRY-A EUROPEAN JOURNAL　Vol. 21　No. 12　p. 4695-4702　2015/03　Research paper (scientific journal)

Nonlinear fluorescence imaging by photoinduced charge separation

Mochizuki Kentaro, Shi Lanting, Mizukami Shin, Yamanaka Masahito, Tanabe Mamoru, Gong Wei-Tao, Palonpon Almar, Kawano Shogo, Kawata Satoshi, Kikuchi Kazuya, Fujita Katsumasa

Jpn. J. Appl. Phys.　Vol. 54　No. 4　p. 42403-42403　2015/03　Research paper (scientific journal)

Intramolecular Long-Distance Nucleophilic Reactions as a Rapid Fluorogenic Switch Applicable to the Detection of Enzymatic Activity

Baba, R, Hori, Y, Kikuchi, K

Chem. Eur. J.　Vol. 21　p. 4695-4702　2015/03　Research paper (scientific journal)

Mesoporous Silica Nanoparticles for 19F Magnetic Resonance Imaging, Fluorescence Imaging, and Drug Delivery

T. Nakamaura, F. Sugihara, H. Matsushita, Y. Yoshioka, S. Mizukami, K. Kikuchi

Chem. Sci.　Vol. 6　No. 3　p. 1986-1990　2015/01　Research paper (scientific journal)

Activatable¹⁹F MRI Nanoparticle Probes for the Detection of Reducing Environments

Tatsuya Nakamura, Hisashi Matsushita, Fuminori Sugihara, Yoshichika Yoshioka, Shin Mizukami, Kazuya Kikuchi

Angewandte Chemie International Edition　Vol. 54　No. 3　p. 1007-1010　2014/11/20　Research paper (scientific journal)

Membrane protein CNNM4–dependent Mg²+ efflux suppresses tumor progression

Yosuke Funato, Daisuke Yamazaki, Shin Mizukami, Lisa Du, Kazuya Kikuchi, Hiroaki Miki

Journal of Clinical Investigation　Vol. 124　No. 12　p. 5398-5410　2014/10/27　Research paper (scientific journal)

Development of a fluorescent probe providing nonlinear response through intramolecular electron transfer

Mochizuki K, Shi L, Mizukami S, Yamanaka M, Tanabe M, Gong W.T, Kawano S, Smith N.I, Kawata S, Kikuchi K, Fujita K

JSAP-OSA Joint Symposia, JSAP 2014　2014/09　Research paper (conference, symposium, etc.)

Development of a Fluorogenic Probe Based on a DNA Staining Dye for Continuous Monitoring of the Histone Deacetylase Reaction

Masafumi Minoshima, Tetsuaki Matsumoto, Kazuya Kikuchi

Analytical Chemistry　Vol. 86　p. 7925-7930　2014/07　Research paper (scientific journal)

¹H MRI Detection of Gene Expression in Living Cells by Using Protein Tag and Biotinylation Probe

Akimasa Yoshimura, Shin Mizukami, Yuki Mori, Yoshichika Yoshioka, Kazuya Kikuchi

Chemistry Letters　Vol. 43　No. 2　p. 219-221　2014/02/05　Research paper (scientific journal)

Ratiometric MRI Sensors Based on Core-Shell Nanoparticles for Quantitative pH Imaging

Satoshi Okada, Shin Mizukami, Takao Sakata, Yutaka Matsumura, Yoshichika Yoshioka, Kazuya Kikuchi

Advanced Materials　Vol. 26　No. 19　p. 2989-2992　2014/01/22　Research paper (scientific journal)

Multifunctional Core-Shell Silica Nanoparticles for Highly Sensitive¹⁹F Magnetic Resonance Imaging

Hisashi Matsushita, Shin Mizukami, Fuminori Sugihara, Yosuke Nakanishi, Yoshichika Yoshioka, Kazuya Kikuchi

Angewandte Chemie International Edition　Vol. 53　No. 4　p. 1008-1011　2014/01/20　Research paper (scientific journal)

Basolateral Mg²+ Extrusion via CNNM4 Mediates Transcellular Mg²+ Transport across Epithelia: A Mouse Model

Daisuke Yamazaki, Yosuke Funato, Jiro Miura, Sunao Sato, Satoru Toyosawa, Kazuharu Furutani, Yoshihisa Kurachi, Yoshihiro Omori, Takahisa Furukawa, Tetsuya Tsuda, Susumu Kuwabata, Shin Mizukami, Kazuya Kikuchi, Hiroaki Miki

PLoS Genetics　Vol. 9　No. 12　p. e1003983-e1003983　2013/12/05　Research paper (scientific journal)

Dynamic Visualization of RANKL and Th17-mediated Control of Osteoclast Function

J. Kikuta, Y. Wada, T. Kowada, Z. Wang, G.-H. Sun-Wada, I. Nishiyama, S. Mizukami, N. Maiya, H. Yasuda, A. Kumanogoh, K. Kikuchi, R.N. Germain, M. Ishii

J. Clin. Invest.　2013/12　Research paper (scientific journal)

pH Induced dual “OFF–ON–OFF” switch: influence of a suitably placed carboxylic acid

Kalyan K. Sadhu, Shin Mizukami, Akimasa Yoshimura, Kazuya Kikuchi

Org. Biomol. Chem.　Vol. 11　No. 4　p. 563-568　2013/12　Research paper (scientific journal)

A nanospherical polymer as an MRI sensor without paramagnetic or superparamagnetic species

Satoshi Okada, Shin Mizukami, Yutaka Matsumura, Yoshichika Yoshioka, Kazuya Kikuchi

Dalton Transactions　Vol. 42　No. 45　p. 15864-15867　2013/12　Research paper (scientific journal)

Development of cell-impermeable coelenterazine derivatives

Eric Lindberg, Shin Mizukami, Keiji Ibata, Takashi Fukano, Atsushi Miyawaki, Kazuya Kikuchi

Chemical Science　Vol. 4　No. 12　p. 4395-4400　2013/12　Research paper (scientific journal)

Development of Luminescent Coelenterazine Derivatives Activatable by beta-Galactosidase for Monitoring Dual Gene Expression

Eric Lindberg, Shin Mizukami, Keiji Ibata, Atsushi Miyawaki, Kazuya Kikuchi

CHEMISTRY-A EUROPEAN JOURNAL　Vol. 19　No. 44　p. 14970-14976　2013/10　Research paper (scientific journal)

Efficient Formation of Luminescent Lanthanide(III) Complexes by Solid‐Phase Synthesis and On‐Resin Screening

Tatsuya Nakamura, Shin Mizukami, Miho Tanaka, Kazuya Kikuchi

Chemistry – An Asian Journal　Vol. 8　No. 11　p. 2685-2690　2013/08/15　Research paper (scientific journal)

Development of Fluorogenic Probes for Quick No-Wash Live-Cell Imaging of Intracellular Proteins

Vol. 135　p. 12360-12365　2013/05　Research paper (scientific journal)

Dynamic visualization of RANKL and Th17-mediated osteoclast function

Junichi Kikuta, Yoh Wada, Toshiyuki Kowada, Ze Wang, Ge-Hong Sun-Wada, Issei Nishiyama, Shin Mizukami, Nobuhiko Maiya, Hisataka Yasuda, Atsushi Kumanogoh, Kazuya Kikuchi, Ronald N. Germain, Masaru Ishii

Journal of Clinical Investigation　Vol. 123　p. 866-873　2013/01/16　Research paper (scientific journal)

A Long-Lived Luminescent Probe to Sensitively Detect Arylamine N-Acetyltransferase (NAT) Activity of Cells

T. Terai, K. Kikuchi, Y. Urano, H. Kojima, T. Nagano

Chem. Commun.,　2012/12　Research paper (scientific journal)

Salicylic Acid Derivatives as Antennae for Ratiometric Luminescent Probes Based on Lanthanide Complexes

T. Terai, H. Ito, K. Kikuchi, T. Nagano

Chem. Eur. J.,　2012/12　Research paper (scientific journal)

No-Wash Protein Labeling with Designed Fluorogenic Probes and Application to Real-Time Pulse-Chase Analysis

S. Mizukami, S. Watanabe, Y. Akimoto, K. Kikuchi

J. Am. Chem. Soc.　Vol. 134　p. 1623-1629　2012/12　Research paper (scientific journal)

A fluorescent probe for detection of histone deacetylase activity based on aggregation-induced emission

Koushik Dhara, Yuichiro Hori, Reisuke Baba, Kazuya Kikuchi

Chemical Communications　Vol. 48　No. 94　p. 11534-11536　2012/12　Research paper (scientific journal)

Simple and Real-Time Colorimetric Assay for Glycosidases Activity Using Functionalized Gold Nanoparticles and Its Application for Inhibitor Screening

Zhanghua Zeng, Shin Mizukami, Kazuya Kikuchi

Analytical Chemistry　Vol. 84　No. 21　p. 9089-9095　2012/10/09　Research paper (scientific journal)

Development of Fluorogenic Probe with Transesterification switch for Detection of Histone Deacetylase Activity

Baba, R, Hori, Y, Mizukami, Kikuchi, K

J. Am. Chem. Soc.　Vol. 134　p. 14310-14313　2012/09　Research paper (scientific journal)

3PS042 ^<19>F MRI monitoring of Gene Expression in living cells(The 50th Annual Meeting of the Biophysical Society of Japan)

Hisashi Matsushita, Shin Mizukami, Yuki Mori, Fuminori Sugihara, Masahiro Shirakawa, Yoshichika Yoshioka, Kazuya Kikuchi

Seibutsu Butsuri　Vol. 52　No. supplement　p. S153-S153　2012/08　Research paper (scientific journal)

¹⁹F MRI Monitoring of Gene Expression in Living Cells through Cell-Surface β-Lactamase Activity

Hisashi Matsushita, Shin Mizukami, Yuki Mori, Fuminori Sugihara, Masashiro Shirakawa, Yoshichika Yoshioka, Kazuya Kikuchi

ChemBioChem　Vol. 13　No. 11　p. 1579-1583　2012/07/06　Research paper (scientific journal)

Salicylic-Acid Derivatives as Antennae for Ratiometric Luminescent Probes Based on Lanthanide Complexes

Takuya Terai, Hiroki Ito, Kazuya Kikuchi, Tetsuo Nagano

CHEMISTRY-A EUROPEAN JOURNAL　Vol. 18　No. 24　p. 7377-7381　2012/06　Research paper (scientific journal)

Development of Protein-Labeling Probes with a Redesigned Fluorogenic Switch Based on Intramolecular Association for No-Wash Live-Cell Imaging

Yuichiro Hori, Kyohei Nakaki, Motoki Sato, Shin Mizukami, Kazuya Kikuchi

Angewandte Chemie International Edition　Vol. 51　No. 23　p. 5611-5614　2012/04/25　Research paper (scientific journal)

A long-lived luminescent probe to sensitively detect arylamine N-acetyltransferase (NAT) activity of cells

Takuya Terai, Kazuya Kikuchi, Yasuteru Urano, Hirotatsu Kojima, Tetsuo Nagano

CHEMICAL COMMUNICATIONS　Vol. 48　No. 16　p. 2234-2236　2012/02　Research paper (scientific journal)

Inside Cover: Fluorogenic Protein Labeling through Photoinduced Electron Transfer-Based BL-Tag Technology (Chem. Asian J. 2/2012)

Kalyan K. Sadhu, Shin Mizukami, Carolyn R. Lanam, Kazuya Kikuchi

Chemistry - An Asian Journal　Vol. 7　No. 2　p. 246-246　2012/02/01　Research paper (scientific journal)

Switchable MRI contrast agents based on morphological changes of pH-responsive polymers

Satoshi Okada, Shin Mizukami, Kazuya Kikuchi

Bioorganic &amp; Medicinal Chemistry　Vol. 20　No. 2　p. 769-774　2012/01　Research paper (scientific journal)

Two Distinct Amyloid Beta-protein (Abeta) Assembly Pathways Leading to Oligomers and Fibrilsidentified by Combined Fluorescence Correlation Spectroscopy, Morphologyand Toxicity Analyses

S. Matsumura, K. Shinoda, M. Yamada, S. Yokojima, M. Inoue, T. Ohnishi, T.Shimada, K.Kikuchi, D. Masui, S. Hashimoto, M. Sato, A. Ito, M. Akioka, S. Takagi, Y. Nakamura, K.Nemoto, Y. Hasegawa, H. Takamoto, H. Inoue, S. Nakamura, Y. Nabeshima, D.B. Teplow, M. Kinjo, M. Hoshi

J. Biol. Chem.　2011/12　Research paper (scientific journal)

Cell Surface Protein Labeling with Luminescent Nanoparticles via Biotinylation Using Mutant beta-Lactamase-tag Technology

A. Yoshimura, S. Mizukami, Y. Hori, S. Watanabe, K. Kikuchi

ChemBioChem　2011/12　Research paper (scientific journal)

Sequential Ordering Among Multicolor Fluorophores for Protein Labeling Facility via Aggregation-elimination Based ß-Lactam Probes

K.K. Sadhu, S. Mizukami, S. Watanabe, K. Kikuchi

Mol. BioSyst.　2011/12　Research paper (scientific journal)

19F MRI Detection of β-Galactosidase Activity for Imaging of Gene Expression

S. Mizukami, H. Matsushita, R. Takikawa, F. Sugihara, M. Shirakawa, K. Kikuchi

Chem. Sci.,　2011/12　Research paper (scientific journal)

Covalent Protein Labeling with a Lanthanide Complex and its Application to Photoluminescence Lifetime-based Multicolor Bioimaging

S. Mizukami, T. Yamamoto, A. Yoshimura, S. Watanabe, K. Kikuchi

Angew. Chem. Int. Ed.　Vol. 50　p. 8750-8752　2011/12　Research paper (scientific journal)

In Vivo Fluorescence Imaging of Bone-Resorbing Osteoclasts

T. Kowada, J. Kikuta, A. Kubo, M. Ishii, H. Maeda, S. Mizukami, K. Kikuchi

J. Am. Chem. Soc.　Vol. 133　p. 17772-17776　2011/12　Research paper (scientific journal)

2SB-02 DESIGN, SYNTHESIS AND BIOLOGICAL APPLICATION OF MOLECULAR IMAGING PROBES WITH TUNABLE CHEMICAL SWITCHES(2SB Frontiers in chemical biology for in-cell biophysics,The 49th Annual Meeting of the Biophysical Society of Japan)

Kikuchi Kazuya

Seibutsu Butsuri　Vol. 51　2011/08　Research paper (scientific journal)

Intracellular Protein Labeling with Prodrug-Like Probes Using a Mutant beta-Lactamase Tag

Shuji Watanabe, Shin Mizukami, Yuri Akimoto, Yuichiro Hori, Kazuya Kikuchi

CHEMISTRY-A EUROPEAN JOURNAL　Vol. 17　No. 30　p. 8342-8349　2011/07　Research paper (scientific journal)

Sequential ordering among multicolor fluorophores for protein labeling facility via aggregation-elimination based β-lactam probes

Kalyan K. Sadhu, Shin Mizukami, Shuji Watanabe, Kazuya Kikuchi

Molecular BioSystems　Vol. 7　No. 5　p. 1766-1772　2011/05/01　Research paper (scientific journal)

Multicolor Protein Labeling in Living Cells Using Mutant b-Lactamase-tag Technology

S. Watanabe, S. Mizukami, Y. Hori, K. Kikuchi

Bioconjugate Chem.,　2010/12　Research paper (scientific journal)

Turn-on Fluorescence Switch Involving Aggregation and Elimination Processes for b-Lactamase-Tag

K.K. Sadhu, S. Mizukami, S. Watanabe, K. Kikuchi

Chem. Commun.,　2010/12　Research paper (scientific journal)

Turn-on fluorescence switch involving aggregation and elimination processes for β-lactamase-tag

Kalyan K. Sadhu, Shin Mizukami, Shuji Watanabe, Kazuya Kikuchi

Chemical Communications　Vol. 46　No. 39　p. 7403-7405　2010/10/21　Research paper (scientific journal)

3P327 Development of a time-resolved fluorescence imaging method for protein analysis(Bioimaging,The 48th Annual Meeting of the Biophysical Society of Japan)

Yamamoto Taku, Mizukami Shin, Kikuchi Kazuya

Seibutsu Butsuri　Vol. 50　No. 2　2010/08　Research paper (scientific journal)

Photocontrolled Compound Release System Using Caged Antimicrobial Peptide

S. Mizukami, M. Hosoda, T. Satake, S. Okada, Y. Hori, T. Furuta, K. Kikuchi

J. Am. Chem. Soc.　Vol. 132　p. 9524-9525　2010/05　Research paper (scientific journal)

Noncovalent-interaction-promoted ligation for protein labeling

Hori Y, Egashira Y, Kamiura R, Kikuchi K

2010/03　Research paper (scientific journal)

Application of Stimuli-responsive Polymer for Development of Novel MRI Probes

Satoshi Okada, Shin Mizukami, Kazuya Kikuchi

ChemBioChem　2010/03　Research paper (scientific journal)

3P330 Development of Photoactive Yellow Protein-based Protein Labeling System with Designed Fluorogenic Probe(Bioimaging,The 48th Annual Meeting of the Biophysical Society of Japan)

Hori Yuichiro, Nakaki Kyohei, Norinobu Tomoya, Kikuchi Kazuya

Seibutsu Butsuri　Vol. 50　No. 2　2010　Research paper (scientific journal)

2P253 Development of drug release system controlled by light irradiation(The 48th Annual Meeting of the Biophysical Society of Japan)

hosoda mariko, mizukami shin, kikuchi kazuya

Seibutsu Butsuri　Vol. 50　No. 2　2010　Research paper (scientific journal)

Zinc is an Essential Trace Element for Spermatogenesis

S. Yamaguchi, C. Miura, F.T. Celino, T. Agusa, S. Tanabe, K. Kikuchi, T. Miura

Proc. Natl. Acad. Sci. U.S.A.　2009/12　Research paper (scientific journal)

Anion Sensor-Based Ratiometric Peptide Probe for Protein Kinase Activity

K. Kikuchi, S. Hashimoto, S. Mizukami, T. Nagano

Org. Lett.,　2009/12　Research paper (scientific journal)

Dual-function probe to detect protease activity for fluorescence measurement and 19F MRI.

Shin Mizukami, Rika Takikawa, Fuminori Sugihara, Masahiro Shirakawa, Kazuya Kikuchi

Angewandte Chemie (International ed. in English)　Vol. 48　No. 20　p. 3641-3　2009/12　Research paper (scientific journal)

Covalent Protein Labeling Based on Noncatalytic beta-Lactamase and a Designed FRET Substrate

Shin Mizukami, Shuji Watanabe, Yuichiro Hori, Kazuya Kikuchi

J. Am. Chem. Soc.　Vol. 131　p. 5016-5017　2009/12　Research paper (scientific journal)

Photoactive yellow protein-based protein labeling system with turn-on fluorescence intensity

Hori Y, Ueno H, Mizukami S, Kikuchi K

J. Am. Chem. Soc.　Vol. 131　p. 16610-16611　2009/12　Research paper (scientific journal)

Design and Synthesis of Coumarin-based Zn2+ Probes for Ratiometric Fluorescence Imaging

Shin Mizukami, Satoshi Okada, Satoshi Kimura, Kazuya Kikuchi

Inorg. Chem.　2009/07　Research paper (scientific journal)

Development of Ratiometric Fluorescent Probes for Phosphatases Using pKa-Switching Mechanism

Shin Mizukami, Shuji Watanabe, Kazuya Kikuchi

ChemBioChem　2009/06　Research paper (scientific journal)

Dual-Function Probe to Detect Protease Activity for Fluorescence Measurement and 19F MRI

Shin Mizukami, Rika Takikawa, Fuminori Sugihara, Masahiro Shirakawa, Kazuya Kikuchi

Angew. Chem. Int. Ed.　Vol. 48　No. 20　p. 3641-3　2009/04　Research paper (scientific journal)

2P-336 Time-resolved long-lived luminescence imaging employing luminescent lanthanide sensor probes(The 46th Annual Meeting of the Biophysical Society of Japan)

Hanaoka Kenjiro, Kikuchi Kazuya, Nagano Tetsuo

Seibutsu Butsuri　Vol. 48　p. S126-S127　2008/10　Research paper (scientific journal)

Lanthanide-based Protease Activity Sensors for Time-resolved Fluorescence Measurements

Shin Mizukami, Kazuhiro Tonai, Masahiro Kaneko, Kazuya Kikuchi

J. Am. Chem. Soc.　Vol. 130　p. 14376-14377　2008/10　Research paper (scientific journal)

Selective Photoinactivation of Protein Function through Environment-sensitive Switching of Singlet Oxygen Generation by Photosensitizer

T. Yogo, Y. Urano, A. Mizushima, H. Sunahara, T. Inoue, K. Hirose, M. Iino, K. Kikuchi, T. Nagano

Proc. Na t. Acad. Sci. U.S.A.　2008/04　Research paper (scientific journal)

A Gd3+-Based Magnetic Resonance Imaging Contrast Agent Sensitive to beta-Galactosidase Activity Utilizing a Receptor-Induced Magnetization Enhancement (RIME) Phenomenon

K. Hanaoka, K. Kikuchi, T. Terai, T. Komatsu, T. Nagano

Chem. Eur. J.　2008/03　Research paper (scientific journal)

Insights into Zn2+ Homeostasis in Neurons from Experimental and Modeling Studies

R.A. Colvin, A.L. Bush, I Volitakis, C.P. Fontaine, D. Thomas, K. Kikuchi, W.R.Holmes

Am. J. Physiol., Cell Physiol.　2008/03　Research paper (scientific journal)

Paramagnetic Relaxation-based 19F MRI Probe to Detect Protease Activity

Shin Mizukami, Rika Takikawa, Fuminori Sugihara, Yuichiro Hori, Hidehito Tochio, Markus Waelchli, Masahiro Shirakawa, Kazuya Kikuchi

J. Am. Chem. Soc.　Vol. 130　No. 3　p. 794-795　2008/01　Research paper (scientific journal)

A Time-resolved Long-lived Luminescence Imaging Method Employing Luminescent Lanthanide Probes with a New Microscopy System

K. Hanaoaka, K. Kikuchi, S. Kobayashi, T. Nagano

J. Am. Chem. Soc.　2007/09　Research paper (scientific journal)

Iron Hydroxide Nanoparticles Coated with Poly(ethylene glycol)-poly(aspartic acid) Block Copolymer as Novel Magnetic Resonance Contrast Agents for in Vivo Cancer Imaging

M. Kumagai, Y. Imai, T. Nakamura, Y. Yamasaki, M. Sekino, S. Ueno, K. Hanaoka, K. Kikuchi, E. Kaneko, K. Shimokado, K. Kataoka

Coll. Surf. B-Bioint.　Vol. 56　No. 1-2　p. 174-81　2007/07　Research paper (scientific journal)

Design and Synthesis of an Enzyme Activity-Based Labeling Molecule with Fluorescence Spectral Change

T. Komatsu, K. Kikuchi, H. Takakusa, K. Hanaoka, T. Ueno, M. Kamiya, Y. Urano, T. Nagano

J. Am. Chem. Soc.　Vol. 128　No. 50　p. 15946-15947　2006/12　Research paper (scientific journal)

Toward Bifunctional Antibody Catalysis

K. Kikuchi, R.B. Hannak, M.J. Guo, A.J. Kirby, D. Hilvert

Bioorg. Med. Chem.　2006/10　Research paper (scientific journal)

Fluorescence-based Zinc Ion Sensor for Zinc Ion Release from Pancreatic Cells

G. Crivat, K. Kikuchi, T. Nagano, T. Priel, M. Hershfinkel, I. Sekler, N. Rozenzweig, Z. Rosenzweig

Anal. Chem.　2006/10　Research paper (scientific journal)

Modulation of Luminescence Intensity of Lanthanide Complexes by Photoinduced Electron Transfer and its Application to a Long-Lived Protease Probe

T. Terai, K. Kikuchi, S. Iwasawa, T. Kawabe, Y. Hirata, Y. Urano, T. Nagano

J. Am. Chem. Soc.　2006/04　Research paper (scientific journal)

Inhibition of Presynaptic Activity by Zinc Released From Mossy Terminals During Tetanic Stimulation

A. Minami, N. Sakurada, S. Fuke, K. Kikuchi, T. Nagano, N. Oku, A. Takeda

J. Neurosci. Res.　Vol. 83　p. 167-176　2006/01　Research paper (scientific journal)

[Analysis of intracellular membrane protein function by small molecule-based chromophore-assisted laser inactivation].

Kazuya Kikuchi, Kenzo Hirose, Masamitsu Iino, Tetsuo Nagano

Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme　Vol. 50　No. 10 Suppl　p. 1388-94　2005/08　Research paper (scientific journal)

Analysis of intracellular membrane protein function by small molecule-based chromophore-assisted laser inactivation

T Yogo, K Kikuchi, T Inoue, K Hirose, M Iino, T Nagano

YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN　Vol. 124　p. 301-304　2005/08　Research paper (scientific journal)

Evidence for pH Dependent Zn2+ Influx in K562 Erythroleukemia Cells: Studies Using ZnAF-2F Fluorescence and Zn-65(2+) Uptake

R.A.Colvin, P. Fontaine, D. Thomas, T. Hirano, T. Nagano, K. Kikuchi

Arch. Biochem. Biophys　2005/08　Research paper (scientific journal)

Inhibition of Autotaxin by Lysophosphatidic Acid and Sphingosine-1-phosphate

L.A. van Meeteren, P. Ruurs, E. Christodoulou, J.W. Goding, H. Takakusa, K. Kikuchi, A. Perrakis, T. Nagano, W.H. Moolenaar

J. Biol. Chem.　2005/08　Research paper (scientific journal)

Selective zinc sensor molecules with various affinities for Zn2+, revealing dynamics andregional distribution of synaptically released Zn2+ in hippocampal slices

K. Komatsu, K. Kikuchi, Y. Urano, H. Kojima, T. Nagano

J. Am. Chem. Soc.　Vol. 127　p. 10197-10204　2005/07　Research paper (scientific journal)

Highly Sensitive Near-infrared Fluorescence Probes for Nitric Oxide and Their Application to Isolated Organs

E. Sasaki, H. Kojima, H. Nishimatsu, Y. Urano, K. Kikuchi, Y. Hirata, T. Nagano

J. Am. Chem. Soc.　2005/06　Research paper (scientific journal)

3P070 Time-resolved Cellular Imaging Using Novel Zinc Responsive Porobe

Kikuchi K., Hanaoka K., Nagano T.

Seibutsu Butsuri　Vol. 45　2005　Research paper (scientific journal)

Design and Synthesis of Zinc-Selective Chelators for Extracellular Applications

E. Kawabata, K. Kikuchi, Y. Urano, H. Kojima, A. Odani, T. Nagano

J. Am. Chem. Soc.　2005/01　Research paper (scientific journal)

Role of Zinc Ion on the Initiation of Sperm Motility in Starfish

M. Morisawa, K. Komatsu, T. Togo, S. Morisawa, K. Kikuchi, T. Nagano

Zoo. Sci.,　2004/12　Research paper (scientific journal)

A Novel Fluorescent Probe for Zinc Ion Based on Boron Dipyrromethene (BODIPY) Chromophore

H. Koutaka, J. Kosuge, N. Fukasaku, T. Hirano, K. Kikuchi, Y. Urano, H. Kojima, T.Nagano

Chem. Pharm. Bull.　2004/12　Research paper (scientific journal)

Rational Principles for Modulating Fluorescence Properties of Fluorescein

T. Ueno, Y. Urano, K. Setsukinai, H. Takakusa, H. Kojima, K. Kikuchi, K. Ohkubo, S.Fukuzumi, T. Nagano

J. Am. Chem. Soc.　2004/12　Research paper (scientific journal)

Rational Design of Novel Photoinduced Electron Transfer Type Fluorescent Probes for Sodium Cation

S. Kenmoku, Y. Urano, K. Kanda, H. Kojima, K. Kikuchi, T. Nagano

Tetrahedron,　2004/12　Research paper (scientific journal)

Highly Sensitive Fluorescence Probes for Nitric Oxide Based on Boron Dipyrromethene Chromophore -Rational Design of Potentially Useful BioimagingFluorescence Probe-

Y. Gabe, Y. Urano, K. Kikuchi, H. Kojima, T. Nagano

J. Am. Chem. Soc.　2004/12　Research paper (scientific journal)

Distinct Glutamate Receptors Govern Differential Levels of Nitric Oxide Production in a Layer-specific Manner in the Rat Cerebellar Cortex

D. Okada, C.C. Yap, H. Kojima, K. Kikuchi, T. Nagano

Neuroscience　2004/12　Research paper (scientific journal)

Rational principles for modulating fluorescence properties of fluorescein.

Tasuku Ueno, Yasuteru Urano, Ken-Ichi Setsukinai, Hideo Takakusa, Hirotatsu Kojima, Kazuya Kikuchi, Kei Ohkubo, Shunichi Fukuzumi, Tetsuo Nagano

Journal of the American Chemical Society　Vol. 126　No. 43　p. 14079-85　2004/11/03　Research paper (scientific journal)

2P279 Protein tyrosine phosphatase activity is reduced during cell growth, as revealed by ratiometric imaging of living cells

Kikuchi K., Takakusa H., Nagano T., Sawano A., Miyawaki A.

Seibutsu Butsuri　Vol. 44　2004/11　Research paper (scientific journal)

Inactivation of Inositol 1,4,5-Trisphosphate Receptor Using Membrane-permeant Probes

T. Yogo, K. Kikuchi, K. Hirose, M. Iino, T. Nagano

Chemistry & Biology　2004/10　Research paper (scientific journal)

Development of a Zinc Ion-selective Luminescent Lanthanide Chemosensor forBiological Applications

K. Hanaoka, K. Kikuchi, H. Kojima, Y. Urano, T. Nagano

J. Am. Chem. Soc.　2004/09　Research paper (scientific journal)

Albumin Catalysis of the Base-Promoted Ring-Opening Reactions of Benzisoxazole

Y. Hu, K.N. Houk, K. Kikuchi, K. Hotta, D. Hilvert

J. Am. Chem. Soc.　2004/08　Research paper (scientific journal)

A novel fluorescent probe for zinc ion based on boron dipyrromethene (BODIPY) chromophore

H Koutaka, J Kosuge, N Fukasaku, T Hirano, K Kikuchi, Y Urano, H Kojima, T Nagano

CHEMICAL & PHARMACEUTICAL BULLETIN　Vol. 52　No. 6　p. 700-703　2004/06　Research paper (scientific journal)

Highly Sensitive Fluorescence Probes for Nitric Oxide Based on Boron Dipyrromethene Chromophore -Rational Design of Potentially Useful Bioimaging Fluorescence Probe-

Y. Gabe, Y. Urano, K. Kikuchi, H. Kojima, T. Nagano

J. Am. Chem. Soc.　2004/06　Research paper (scientific journal)

Distinct Glutamate Receptors Govern DifferentialLevels of Nitric Oxide Production in a Layer-specific Manner

D. Okada, C.C. Yap, H. Kojima, K. Kikuchi, T. Nagano

Neuroscience　2004/05　Research paper (scientific journal)

Development of Selective, Visible Light-excitable, Fluorescent Magnesium Probes with a Novel Fluorescence Switching Mechanism

T. Shoda, K. Kikuchi, H. Kojima, Y. Urano, H. Komatsu, K. Suzuki, T. Nagano

The Analyst,　2003/12　Research paper (scientific journal)

A novel design method of ratiometric fluorescent probes based on fluorescence resonance energy transfer switching by spectral overlap integral

TAKAKUSA H.

Chem. Eur. J.　Vol. 9　p. 1479-1485　2003/12　Research paper (scientific journal)

Spatiotemporal Laser Inactivation of Inositol 1,4,5-Trisphosphate Receptors Using Synthetic Small-molecule Probes

T. Inoue, K. Kikuchi, K. Hirose, M. Iino, T. Nagano

Chemistry & Biology,　2003/12　Research paper (scientific journal)

Development and application of novel fluorescent probes for protein tyrosine phosphatase activity

Takakusa H., Kikuchi K., Sawano A., Miyawaki A., Nagano T.

Seibutsu Butsuri　Vol. 43　2003/08　Research paper (scientific journal)

Development of selective, visible light-excitable, fluorescent magnesium ion probes with a novel fluorescence switching mechanism

Takuji Shoda, Kazuya Kikuchi, Hirotatsu Kojima, Yasuteru Urano, Hirokazu Komatsu, Koji Suzuki, Tetsuo Nagano

Analyst　Vol. 128　No. 6　p. 719-723　2003/06/01　Research paper (scientific journal)

Selective Detection of Zinc Ions with Novel Luminescent Lanthanide Probes

K. Hanaoka, K. Kikuchi, H. Kojima, Y. Urano, T. Nagano

Angew. Chem. Int. Ed.　2003/05　Research paper (scientific journal)

Hydrophobic Modifications at 1-Phosphate of Inositol 1,4,5-Trisphosphate Analogues Enhance Receptor Binding

W. Nakanishi, K. Kikuchi, T. Inoue, K. Hirose, M. Iino, T. Nagano

Bioorg. Med. Chem. Lett.　2002/12　Research paper (scientific journal)

Orthogonality of Calcium Concentration and Ability of 4,5-Diaminofluorescein (DAF-2) to Detect NO

N. Suzuki, H. Kojima, Y. Urano, K. Kikuchi, Y. Hirata, T. Nagano

J. Biol. Chem.,　2002/12　Research paper (scientific journal)

Design and Synthesis of a Novel Magnetic Resonance Imaging Contrast Agent for Selective Sensing of Zinc Ion

K. Hanaoka, K. Kikuchi, Y. Urano, M. Narazaki, T. Yokawa, S. Sakamoto, K. Yamaguchi, T. Nagano

Chemistry & Biology　2002/12　Research paper (scientific journal)

A Novel, Cell-Permeable, Fluorescent Probe for Ratiometric Imaging of Zinc Io

S. Maruyama, K. Kikuchi, T. Hirano, Y. Urano, T. Nagano

J. Am. Chem. Soc.　2002/11　Research paper (scientific journal)

Design and synthesis of a novel magnetic resonance imaging contrast agent for selective sensing of zinc ion

K Hanaoka, K Kikuchi, Y Urano, M Narazaki, T Yokawa, S Sakamoto, K Yamaguchi, T Nagano

CHEMISTRY & BIOLOGY　Vol. 9　No. 9　p. 1027-1032　2002/09　Research paper (scientific journal)

Mossy Fiber Zn2+ Spillover Modulates Heterosynaptic N-methyl-D-aspartate Receptor Activity in Hippocampel CA3 Circuits

S. Ueno, M. Tsukamoto, T. Hirano, K. Kikuchi, M. K. Yamada, N. Nishiyama, T. Nagano, N.Matsuki, Y. Ikegaya

J. Cell Biology,　2002/07　Research paper (scientific journal)

Improvement and biological applications of fluorescent probes for zinc, ZnAFs

T Hirano, K Kikuchi, Y Urano, T Nagano

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY　Vol. 124　No. 23　p. 6555-6562　2002/06　Research paper (scientific journal)

Improved Fluorescent Probes for Zinc, ZnAFs, Suitable for Biological Applications

T. Hirano, K. Kikuchi, Y. Urano, T. Nagano

J. Am. Chem. Soc.　2002/06　Research paper (scientific journal)

A Fluorescent Anion Sensor That Works in Neutral Aqueous Solution for Bioanalytical Application

S. Mizukami, T. Nagano, Y. Urano, A. Odani, K. Kikuchi

J. Am. Chem. Soc.　2002/05　Research paper (scientific journal)

Orthogonality of calcium concentration and ability of 4,5-diaminofluorescein to detect NO

N Suzuki, H Kojima, Y Urano, K Kikuchi, Y Hirata, T Nagano

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 277　No. 17　p. 15220-15220　2002/04　Research paper (scientific journal)

Design and Synthesis of an Enzyme-Cleavable Sensor Molecule for Phosphodiesterase Activity Based on Fluorescence Resonance Energy Transfer

H. Takakusa, K. Kikuchi, Y. Urano, S. Sakamoto, K. Yamaguchi, T. Nagano

J. Am. Chem. Soc.　2002/03　Research paper (scientific journal)

2G1645 Development of Novel Fluorescence Resonance Energy Transfer Probes for Ratiometric Measurement of Protein Tyrosine Phosphatase Activity

Takakusa H., Kikuchi K., Nagano T.

Seibutsu Butsuri　Vol. 42　No. 2　2002　Research paper (scientific journal)

Rational Design of Fluorescein-based Fluorescence Probes. -Mechanism-based Design of a Maximum Fluorescence Probe for Singlet Oxygen-

K. Tanaka, T. Miura, N. Umezawa, Y. Urano, K. Kikuchi, T. Higuchi, T. Nagano

J. Am. Chem. Soc.,　2001/12　Research paper (scientific journal)

Visualization of Oxygen Concentration-dependent Production of Nitric Oxide in Rat Hippocampal Slices during Aglycemia

H. Kojima, M. Hirata, Y. Kudo, K. Kikuchi, T. Nagano

J. Neurochem.　2001/12　Research paper (scientific journal)

Bioimaging of Nitric Oxide with Fluorescent Indicators Based on Rhodamine Chromophore

H. Kojima, M. Hirotani, N. Nakatsubo, K. Kikuchi, Y. Urano, T. Higuchi, Y. Hirata, T. Nagano

Anal. Chem.,　2001/12　Research paper (scientific journal)

Intramolecular Fluorescence Resonance Energy Transfer System with Coumarin Donor Included in beta-Cyclodextrin

H. Takakusa, K. Kikuchi, Y. Urano, T. Higuchi, T. Nagano

Anal. Chem.,　2001/12　Research paper (scientific journal)

Small Molecule-based Laser Inactivation of Inositol 1,4,5-Triphosphate Receptor

T. Inoue, K. Kikuchi, K. Hirose, M. Iino, T. Nagano

Chemistry & Biology,　2001/12　Research paper (scientific journal)

Selective sensing of zinc ions with a novel magnetic resonance imaging contrast agent

K Hanaoka, K Kikuchi, Y Urano, T Nagano

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2　No. 9　p. 1840-1843　2001/09　Research paper (scientific journal)

Bioimaging of nitric oxide with fluorescent indicators based on the rhodamine chromophore

H. Kojima, M. Hirotani, N. Nakatsubo, K. Kikuchi, Y. Urano, T. Higuchi, Y. Hirata, T. Nagano

Analytical Chemistry　Vol. 73　No. 9　p. 1967-1973　2001/05/01　Research paper (scientific journal)

Selective inhibition of human inducible nitric oxide synthase by S-alkyl-L-isothiocitrulline-containing dipeptides

JM Park, J Higuchi, K Kikuchi, Y Urano, H Hori, T Nishino, J Aoki, K Inoue, T Nagano

BRITISH JOURNAL OF PHARMACOLOGY　Vol. 132　No. 8　p. 1876-1882　2001/04　Research paper (scientific journal)

Intramolecular fluorescence resonance energy transfer system with coumarin donor included in β-cyclodextrin

H. Takakusa, K. Kikuchi, Y. Urano, T. Higuchi, T. Nagano

Analytical Chemistry　Vol. 73　No. 5　p. 939-942　2001/03/01　Research paper (scientific journal)

First Synthetic NO-heme-thiolate Complex Relevant to Nitric Oxide Synthase and Cytochrome P450nor

N. Suzuki, T. Higuchi, Y. Urano, K. Kikuchi, T. Uchida, M. Mukai, T. Kitagawa, T. Nagano

J. Am. Chem. Soc.,　2000/12　Research paper (scientific journal)

Fluorescence Switching by O-Dearylation of 7-Aryloxycoumarins.-Development of Novel Fluorescence Probes to Detect Reactive Oxygen Species with High Selectivity

K. Setsukinai, Y. Urano, K. Kikuchi, T. Higuchi, T. Nagano

J. Chem. Soc. Perk. Trans.　2000/12　Research paper (scientific journal)

A New Thioether-ligated Iron Porphyrin as a Model of a Protonated Form of P450 Active Site

T. Dokoh, N. Suzuki, T. Higuchi, Y. Urano, K. Kikuchi, T. Nagano

J. Inorg. Biochem.,　2000/12　Research paper (scientific journal)

Superoxide Dismutase Activity of Iron(II)TPEN Complex and Its Derivatives.

TAMURA Masakazu, URANO Yasuteru, KIKUCHI Kazuya, HIGUCHI Tsunehiko, HIROBE Masaaki, NAGANO Tetsuo

Chemical and Pharmaceutical Bulletin　Vol. 48　No. 10　p. 1514-1518　2000/12　Research paper (scientific journal)

Synthesis and Superoxide Dismutase Activity of Novel Iron Complexes

M. Tamura, Y. Urano, K. Kikuchi, T. Higuchi, M. Hirobe, T. Nagano

J. Organomet. Chem.,　2000/12　Research paper (scientific journal)

Fluorescence indicators for nitric oxide based on rhodamine chromophore

KOJIMA H.

Tetrahedron Lett.　Vol. 41　p. 69-72　2000/12　Research paper (scientific journal)

Characterization of Proton-Transfer Catalysis by Serum Albumins

F. Hollfelder, A. J. Kirby, D. S. Tawfik, K. Kikuchi, D. Hilvert

J. Am. Chem. Soc.,　2000/12　Research paper (scientific journal)

Decarboxylation of 3-Carboxybenzisoxazoles by Hydrophobic Antibody Binding Pockets

K. Hotta, K. Kikuchi, D. Hilvert

Helv. Chem. Acta,　2000/12　Research paper (scientific journal)

Development of Time-resolved Fluorometric Detection System Using Diffusion-enhanced Energy Transfer

M. Koresawa, K. Kikuchi, S. Mizukami, H. Kojima, Y. Urano, T. Higuchi, T. Nagano

Anal. Chem.,　2000/12　Research paper (scientific journal)

Design and Synthesis of Intramolecular Resonance Energy Transfer Probes for Use in Ratiometric Measurements in Aqueous Solution

Y. Kawanishi, K. Kikuchi, H. Takakusa, S. Mizukami, Y. Urano, T. Higuchi, T.Nagano

Angew. Chem. Int. Ed.,　2000/12　Research paper (scientific journal)

Highly Zinc-selective Fluorescent Sensor Molecules Suitable for Biological Applications

T. Hirano, K. Kikuchi, Y. Urano, T. Higuchi, T. Nagano

J. Am. Chem. Soc.　2000/12　Research paper (scientific journal)

Remarkable axial thiolate ligand effect on the oxidation of hydrocarbons by active intermediate of iron porphyrin and cytochrome P450

T Ohno, N Suzuki, T Dokoh, Y Urano, K Kikuchi, M Hirobe, T Higuchi, T Nagano

JOURNAL OF INORGANIC BIOCHEMISTRY　Vol. 82　No. 1-4　p. 123-125　2000/11　Research paper (scientific journal)

A new thioether-ligated iron porphyrin as a model of a protonated form of P450 active site

T Dokoh, N Suzuki, T Higuchi, Y Urano, K Kikuchi, T Nagano

JOURNAL OF INORGANIC BIOCHEMISTRY　Vol. 82　No. 1-4　p. 127-132　2000/11　Research paper (scientific journal)

Development of a time-resolved fluorometric detection system using diffusion-enhanced energy transfer

M Koresawa, K Kikuchi, S Mizukami, H Kojima, Y Urano, T Higuchi, T Nagano

ANALYTICAL CHEMISTRY　Vol. 72　No. 20　p. 4904-4907　2000/10　Research paper (scientific journal)

Novel zinc fluorescent probes excitable with visible light for biological applications

T Hirano, K Kikuchi, Y Urano, T Higuchi, T Nagano

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION　Vol. 39　No. 6　p. 1052-+　2000/03　Research paper (scientific journal)

Effects of tetrahydrobiopterin on endothelial dysfunction in rats with ischemic acute renal failure

M Kakoki, Y Hirata, H Hayakawa, E Suzuki, D Nagata, A Tojo, H Nishimatsu, N Nakanishi, Y Hattori, K Kikuchi, T Nagano, M Omata

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY　Vol. 11　No. 2　p. 301-309　2000/02　Research paper (scientific journal)

Novel Iron Porphyrin-alkanethiolate Complex with Intramolecular NH...S Hydrogen Bond: Synthesis, Spectroscopy and Reactivity

N. Suzuki, T. Higuchi, Y. Urano, K. Kikuchi, H. Uekusa, Y. Ohashi, T. Uchida, T.Kitagawa, T. Nagano

J. Am. Chem. Soc.,　1999/12　Research paper (scientific journal)

Dipeptides Containing L-Arginine Analogs: New Isozyme-selective Inhibitors of Nitric Oxide Synthase

N. Kobayashi, T. Higuchi, Y. Urano, K. Kikuchi, M. Hirobe, T. Nagano

Biol. Pharm. Bull.,　1999/12　Research paper (scientific journal)

Effects of vasodilatory β-adrenoceptor antagonists on endothelium-derived nitric oxide release in rat kidney

KAKOKI M.

Hypertension　Vol. 33　p. 467-471　1999/12　Research paper (scientific journal)

Role of nitric oxide-cGMP pathway in adrenomedullin-induced vasodilation in the rat

HAYAKAWA H

Hypertension　Vol. 33　p. 689-693　1999/12　Research paper (scientific journal)

Effects of hypertension, diabetes mellitus and hypercholesterolemia on endothelin type B receptor-mediated nitric oxide release from rat kidney

KAKOKI M.

Circulation　Vol. 99　p. 1242-1248　1999/12　Research paper (scientific journal)

Fluorescent Indicators for Imaging Nitric Oxide Production

H. Kojima, Y. Urano, K. Kikuchi, T. Higuchi, T. Nagano

Angew. Chem. Int. Ed.,　1999/12　Research paper (scientific journal)

Novel Fluorescent Probes for Singlet Oxygen

N. Umezawa, K. Tanaka, Y. Urano, K. Kikuchi, T. Higuchi, T. Nagano

Angew. Chem. Int. Ed.,　1999/12　Research paper (scientific journal)

Synthesis and Evaluation of 1-Position-modified Inositol 1,4,5-Trisphosphate Analogs

T. Inoue, K. Kikuchi, K. Hirose, M. Iino, T. Nagano

Bioorg. Med. Chem. Lett.,　1999/12　Research paper (scientific journal)

Imaging of caspase-3 activation in HeLa cells stimulated with etoposide using a novel fluorescent probe.

S Mizukami, K Kikuchi, T Higuchi, Y Urano, T Mashima, T Tsuruo, T Nagano

FEBS letters　Vol. 453　No. 3　p. 356-60　1999/06/25　Research paper (scientific journal)

Real Time Measurement of Nitric Oxide Released from Cultured Endothelial Cells

KURUMATANI Hajimu, KIKUCHI Kazuya, NAGANO Tetsuo, HIROBE Masaaki, YAMAZAKI Jun, NAGAO Taku

Biological and Pharmaceutical Bulletin　Vol. 21　No. 12　p. 1286-1289　1998/12　Research paper (scientific journal)

Selective Deoxygenation of Heteroaromatic N-Oxides with Olefins Catalyzed by Ruthenium Porphyrin

H. Nakagawa, T. Higuchi, K. Kikuchi, Y. Urano, T. Nagano

Chem. Pharm. Bull.,　1998/12　Research paper (scientific journal)

Improved Nitric Oxide Detection Using 2,3-Diaminonaphthalene and Its Applicatio to the Evaluation of Novel Nitric Oxide Synthase Inhibitors

NAKATSUBO Naoki, KOJIMA Hirotatsu, SAKURAI Kuniko, KIKUCHI Kazuya, NAGOSHI Hiroshi, HIRATA Yasunobu, AKAIKE Takaaki, MAEDA Hiroshi, URANO Yasuteru, HIGUCHI Tsunehiko, NAGANO Tetsuo

Biological and Pharmaceutical Bulletin　Vol. 21　No. 12　p. 1247-1250　1998/12　Research paper (scientific journal)

Development of a fluorescent indicator for nitric oxide based on the fluorescein chromophore

KOJIMA H.

Chem. Pharm. Bull. Tokyo　Vol. 46　No. 2　p. 373-375　1998/12　Research paper (scientific journal)

Direct Evidence of Nitric Oxide Production from Bovine Aortic Endothelial Cells Using New Fluorescence Indicators: Diaminofluoresceins

N. Nakatsubo, H. Kojima, K. Kikuchi, H. Nagoshi, Y. Hirata, D. Maeda, Y. Imai, T. Irimura, T. Nagano

FEBS Lett.,　1998/12　Research paper (scientific journal)

Detection and imaging of nitric oxide with novel fluorescent indicators:diaminofluressceins

KOJIMA H.

Anal. Chem.　Vol. 70　p. 2446-2453　1998/12　Research paper (scientific journal)

Direct evidence of NO production in rat hippocampus and cortex using a new fluorescent indicator: DAF-2 DA

Hirotatsu Kojima, Naoki Nakatsubo, Kazuya Kikuchi, Yasuteru Urano, Tsunehiko Higuchi, Junji Tanaka, Yoshihisa Kudo, Tetsuo Nagano

NeuroReport　Vol. 9　No. 15　p. 3345-3348　1998/10/26　Research paper (scientific journal)

Direct evidence of nitric oxide production from bovine aortic endothelial cells using new fluorescence indicators: Diaminofluoresceins

Naoki Nakatsubo, Hirotatsu Kojima, Kazuya Kikuchi, Hiroshi Nagoshi, Yasunobu Hirata, Daisuke Maeda, Yasuyuki Imai, Tatsuro Irimura, Tetsuo Nagano

FEBS Letters　Vol. 427　No. 2　p. 263-266　1998/05/08　Research paper (scientific journal)

Development of a Fluorescent Indicator for the Bioimaging of Nitric Oxide

KOJIMA Hirotatsu, SAKURAI Kuniko, KIKUCHI Kazuya, KAWAHARA Shigenori, KIRINO Yutaka, NAGOSHI Hiroshi, HIRATA Yasunobu, AKAIKE Takaaki, MAEDA Hiroshi, NAGANO Tetsuo

Biological and Pharmaceutical Bulletin　Vol. 20　No. 12　p. 1229-1232　1997/12　Research paper (scientific journal)

Real-time measurement of nitric oxide production in rat brain by the combination of luminol-H2O2 chemiluminescence and microdialysis

Hirotatsu Kojima, Kazuya Kikuchi, Masaaki Hirobe, Tetsuo Nagano

Neuroscience Letters　Vol. 233　No. 2-3　p. 157-159　1997/09/19　Research paper (scientific journal)

Receptor subtype for vasopressin-induced release of nitric oxide from rat kidney

Y Hirata, H Hayakawa, M Kakoki, A Tojo, E Suzuki, D Nagata, K Kimura, A Goto, K Kikuchi, T Nagano, M Hirobe, M Omata

HYPERTENSION　Vol. 29　No. 1　p. 58-64　1997/01　Research paper (scientific journal)

Nitric oxide release from kidneys of hypertensive rats treated with imidapril

HIRATA Y.

Hypertension　Vol. 27　p. 672-678　1996/12　Research paper (scientific journal)

Nobel Detection Method of Nitric Oxide Using Horseradish Peroxidase

K. Kikuchi, T. Nagano, M. Hirobe

Biol. Pharm. Bull.,　1996/12　Research paper (scientific journal)

Antibody Catalysis Via Strategic Use of Haptenic Charge

K. Kikuchi, D. Hilvert

Acta Chem. Scand.,　1996/12　Research paper (scientific journal)

Albumin-catalyzed Proton Transfer

K. Kikuchi, S. N. Thor, D. Hilvert

J. Am. Chem. Soc.,　1996/12　Research paper (scientific journal)

Novel detection method of nitric oxide using horseradish peroxidase

Kazuya Kikuchi, Tetsuo Nagano, Masaaki Hirobe

Biological and Pharmaceutical Bulletin　Vol. 19　No. 4　p. 649-651　1996　Research paper (scientific journal)

Endthelium-derived relaxing factors In the kidney of spontaneously hypertensive rats

HAYAKAWA H.

Life science　Vol. 56　No. 21　p. PL401-PL408　1995/12　Research paper (scientific journal)

Direct measurements of endothelium-derived nitric oxide release by stimulation of endothelin receptors in rat kidney and its alteration in salt-induced hypertension

HIRATA Y.

Circulation　Vol. 91　p. 1229-1235　1995/12　Research paper (scientific journal)

LONG-TERM ADMINISTRATION OF L-ARGININE IMPROVES NITRIC-OXIDE RELEASE FROM KIDNEY IN DEOXYCORTICOSTERONE ACETATE SALT HYPERTENSIVE RATS

H HAYAKAWA, Y HIRATA, E SUZUKI, K KIMURA, K KIKUCHI, T NAGANO, M HIROBE, M OMATA

HYPERTENSION　Vol. 23　No. 6　p. 752-756　1994/06　Research paper (scientific journal)

Mechanisms for Altered Endothelium-dependent Vasodilation in Isolated Kidneys from SHR, DOCA-salt Hypertensive Rat and Dahl Salt-sensitive Rats

H. Hayakawa, Y. Hirata, E. Suzuki, T. Sugimoto, H. Matsuoka, K. Kikuchi, T. Nagano, M. Hirobe, T. Sugimoto

Am. J. Physiol.,　1993/12　Research paper (scientific journal)

Detection of Nitric Oxide Production from a Perfused Organ by a Luminol-H2O2 System

K. Kikuchi, T. Nagano, H. Hayakawa, Y. Hirata, M. Hirobe

Anal. Chem.,　1993/12　Research paper (scientific journal)

Real time measurement of nitric oxide produced ex vivo by luminol-H2O2 chemiluminescence method.

K Kikuchi, T Nagano, H Hayakawa, Y Hirata, M Hirobe

Journal of Biological Chemistry　Vol. 268　No. 31　p. 23106-23110　1993/11　Research paper (scientific journal)

DETECTION OF NITRIC OXIDE PRODUCTION FROM RAT PERFUSED KIDNEYS BY A LUMINOL-H2O2 SYSTEM

K KIKUCHI, T NAGANO, H HAYAKAWA, Y HIRATA, M HIROBE

BIOLOGY OF NITRIC OXIDE, PT 4　Vol. 8　p. 205-208　1993/07　Research paper (international conference proceedings)

MECHANISMS FOR ALTERED ENDOTHELIUM-DEPENDENT VASORELAXATION IN ISOLATED KIDNEYS FROM EXPERIMENTAL HYPERTENSIVE RATS

H HAYAKAWA, Y HIRATA, E SUZUKI, T SUGIMOTO, H MATSUOKA, K KIKUCHI, T NAGANO, M HIROBE, T SUGIMOTO

AMERICAN JOURNAL OF PHYSIOLOGY　Vol. 264　No. 5　p. H1535-H1541　1993/05　Research paper (scientific journal)

New method of detecting nitric oxide production.

KIKUCHI Kazuya, HAYAKAWA Hiroshi, NAGANO Tetsuo, HIRATA Yasunobu, SUGIMOTO Tsuneaki, HIROBE Masaaki

Chemical and Pharmaceutical Bulletin　Vol. 40　No. 8　p. 2233-2235　1992/12　Research paper (scientific journal)

Metabolism and Penetration through Blood-brain-barrier of Parkinsonism-related Compounds -1,2,3,4-Tetrahydroisoquinoline and 1-Methyl-1,2,3,4-tetrahydroisoquinoline-

K. Kikuchi, Y. Nagatsu, Y. Makino, T. Mashino, S. Ohta, M. Hirobe

Drug Met. Disp.,　1991/12　Research paper (scientific journal)

Metabolism and blood-brain barrier permeability of tiqs: Relation to Parkinson's disease

S. Ohta, O. Tachikawa, Y. Makino, K. Kikuchi, T. Mashino, M. Hirobe

Journal of Pharmacobio-Dynamics　Vol. 12　No. 3　1989　Research paper (scientific journal)