顔写真

PHOTO

Yamamoto Jumpei
山元　淳平
Yamamoto Jumpei
山元　淳平
Institutional repository
Graduate School of Engineering Science　Department of Materials Engineering Science，Associate Professor

keyword Photobiology，Nucleic Acids Chemistry，Photolyase，DNA damage，DNA repair

Institutional repository

Research History 7

  1. 2021/04 - Present
    JST創発的研究支援事業　研究者

  2. 2019/07 - Present
    Graduate School of Engineering Science　Associate Professor

  3. 2017/04 - 2019/06
    Osaka University　Graduate School of Engineering Science　Lecturer

  4. 2009/10 - 2017/03
    Osaka University　Graduate School of Engineering Science　Asistant professor

  5. 2014/09 - 2014/11
    CEA Saclay　Visiting researcher

  6. 2011/03 - 2012/02
    Ecole Normale Superieure Paris　Visiting researcher

  7. 2008/04 - 2009/09
    Japan Society for the Promotion of Science

Education 2

  1. Osaka University　Graduate School of Engineering Science　Department of Materials Engineering Science Division of Chemistry

    2005/04 - 2009/09

  2. Osaka University　School of Engineering Science Direct Affiliates　Department of Chemical Sciece and Engineering

    2001/04 - 2005/03

Committee Memberships 1

  1. 日本化学会近畿支部　幹事　Academic society

    2018/03 - 2020/02

Professional Memberships 2

  1. THE BIOPHYSICAL SOCIETY OF JAPAN

  2. THE MOLECULAR BIOLOGY SOCIETY OF JAPAN

Research Areas 3

  1. Life sciences / Functional biochemistry /

  2. Nanotechnology/Materials / Biochemistry /

  3. Life sciences / Biophysics /

Awards 3

  1. The 10th young researcher award

    Junpei Yamamoto　The Biophysical Society of Japan　2014/09

  2. Outstanding Oral Presentation Award

    Junpei Yamamoto　The 39th International Symposium on Nucleic Acids Chemistry　2012/11

  3. Best Poster Award (Nucleic Acids Research Award)

    Junpei Yamamoto　The 6th International Symposium on Nucleic Acids Chemistry　2009/09

Papers 60

  1. Infrared and ultraviolet spectroscopic characterization of a key intermediate during DNA repair by (6-4) photolyase

    Daichi Yamada, Ai Kadono, Tatsumi Maeno, Wataru Sato, Sachiko Yanagiwasa, Toshihiko Hamamura, Yasuteru Shigeta, Junpei Yamamoto, Minoru Kubo

    Communications Chemistry　Vol. 8　2025/08/29　Research paper (scientific journal)

  2. Revisiting the co-crystal structure of a DNA glycosylase with photocaged substrate: a suitable time-resolved crystallography target?

    Tomoki Imura, Yuhei Hosokawa, Kai-Chun Yang, Yuki Ban, Hsuan-Yu Shih, Junpei Yamamoto, Manuel Maestre-Reyna

    IUCrJ　Vol. 12　No. 5　p. 515-522　2025/07/14　Research paper (scientific journal)

  3. Capturing structural intermediates in an animal-like cryptochrome photoreceptor by time-resolved crystallography

    Manuel Maestre-Reyna, Yuhei Hosokawa, Po-Hsun Wang, Martin Saf, Nicolas Caramello, Sylvain Engilberge, Sophie Franz-Badur, Eka Putra Gusti Ngurah Putu, Mai Nakamura, Wen-Jin Wu, Hsiang-Yi Wu, Cheng-Chung Lee, Wei-Cheng Huang, Kai-Fa Huang, Yao-Kai Chang, Cheng-Han Yang, Meng-Iao Fong, Wei-Ting Lin, Kai-Chun Yang, Yuki Ban, Tomoki Imura, Atsuo Kazuoka, Eisho Tanida, Shigeki Owada, Yasumasa Joti, Rie Tanaka, Tomoyuki Tanaka, Jungmin Kang, Fangjia Luo, Kensuke Tono, Stephan Kiontke, Lukas Korf, Yasufumi Umena, Takehiko Tosha, Yoshitaka Bessho, Eriko Nango, So Iwata, Antoine Royan, Ming-Daw Tsai, Junpei Yamamoto, Lars-Oliver Essen

    Science Advances　Vol. 11　2025/05/17　Research paper (scientific journal)

  4. Redox-State-Dependent Structural Changes within a Prokaryotic 6–4 Photolyase

    Po-Hsun Wang, Yuhei Hosokawa, Jessica C Soares, Hans-Joachim Emmerich, Valeri Fuchs, Nicolas Caramello, Sylvain Engilberge, Andrea Bologna, Christian Joshua Rosner, Mai Nakamura, Mohamed Watad, Fangjia Luo, Shigeki Owada, Takehiko Tosha, Jungmin Kang, Kensuke Tono, Yoshitaka Bessho, Eriko Nango, Antonio J. Pierik, Antoine Royan, Ming-Daw Tsai, Junpei Yamamoto, Manuel Maestre-Reyna, Lars-Oliver Essen

    Journal of the American Chemical Society　Vol. 147　No. 19　p. 16084-16098　2025/04　Research paper (scientific journal)

  5. Profiling of i-motif-binding proteins reveals functional roles of nucleolin in regulation of high-order DNA structures

    Yuki Ban, Yuka Ando, Yuma Terai, Risa Matsumura, Keita Nakane, Shigenori Iwai, Shinichi Sato, Junpei Yamamoto

    Nucleic Acids Research　Vol. 52　No. 22　p. 13530-13543　2024/11/19　Research paper (scientific journal)

  6. Structure-specific DNA endonuclease T7 endonuclease I cleaves DNA containing UV-induced DNA lesions

    Kazuki Matsubara, Shouta Ueda, Junpei Yamamoto, Shigenori Iwai, Narumi Aoki Shioi, Arato Takedachi, Isao Kuraoka

    The Journal of Biochemistry　Vol. 176　No. 1　p. 35-42　2024/03/01　Research paper (scientific journal)

    Publisher: Oxford University Press (OUP)

  7. Visualizing the DNA repair process by a photolyase at atomic resolution

    Manuel Maestre-Reyna, Po-Hsun Wang, Eriko Nango, Yuhei Hosokawa, Martin Saf, Antonia Furrer, Cheng-Han Yang, Eka Putra, Gusti Ngurah Putu, Wen-Jin Wu, Hans-Joachim Emmerich, Nicolas Caramello, Sophie Franz-Badur, Chao Yang, Sylvain Engilberge, Maximilian Wranik, Hannah Louise Glover, Tobias Weiner, Hsiang-Yi Wu, Cheng-Chung Lee, Wei-Cheng Huang, Kai-Fa Huang, Yao-Kai Chang, Jiahn-Haur Liao, Jui-Hung Weng, Wael Gad, Chiung-Wen Chang, Allan H. Pang, Kai-Chun Yang, Wei-Ting Lin, Yu-Chen Chang, Dardan Gashi, Emma Beale, Dmitry Ozerov, Karol Nass, Gregor Knopp, Philip J. M. Johnson, Claudio Cirelli, Chris Milne, Camila Bacellar, Michihiro Sugahara, Shigeki Owada, Yasumasa Joti, Ayumi Yamashita, Rie Tanaka, Tomoyuki Tanaka, Fangjia Luo, Kensuke Tono, Wiktoria Zarzycka, Pavel Müller, Maisa Alkheder Alahmad, Filipp Bezold, Valerie Fuchs, Petra Gnau, Stephan Kiontke, Lukas Korf, Viktoria Reithofer, Christian Joshua Rosner, Elisa Marie Seiler, Mohamed Watad, Laura Werel, Roberta Spadaccini, Junpei Yamamoto, So Iwata, Dongping Zhong, Joerg Standfuss, Antoine Royan, Yoshitaka Bessho, Lars-Oliver Essen, Ming-Daw Tsai

    Science　Vol. 382　2023/12　Research paper (scientific journal)

  8. A deazariboflavin chromophore kinetically stabilizes reduced FAD state in a bifunctional cryptochrome

    Yuhei Hosokawa, Hiroyoshi Morita, Mai Nakamura, Junpei Yamamoto

    Scientific Reports　Vol. 13　2023/10　Research paper (scientific journal)

  9. Repair of topoisomerase 1-induced DNA damage by tyrosyl-DNA phosphodiesterase 2 (TDP2) is dependent on its magnesium binding

    Naoto Shimizu, Yusaku Hamada, Ryosuke Morozumi, Junpei Yamamoto, Shigenori Iwai, Kei-ichi Sugiyama, Hiroshi Ide, Masataka Tsuda

    Journal of Biological Chemistry　p. 104988-104988　2023/06　Research paper (scientific journal)

    Publisher: Elsevier BV

  10. Serial crystallography captures dynamic control of sequential electron and proton transfer events in a flavoenzyme

    Manuel Maestre-Reyna, Cheng-Han Yang, Eriko Nango, Wei-Cheng Huang, Eka Putra Gusti Ngurah Putu, Wen-Jin Wu, Po-Hsun Wang, Sophie Franz-Badur, Martin Saft, Hans-Joachim Emmerich, Hsiang-Yi Wu, Cheng-Chung Lee, Kai-Fa Huang, Yao-Kai Chang, Jiahn-Haur Liao, Jui-Hung Weng, Wael Gad, Chiung-Wen Chang, Allan H. Pang, Michihiro Sugahara, Shigeki Owada, Yuhei Hosokawa, Yasumasa Joti, Ayumi Yamashita, Rie Tanaka, Tomoyuki Tanaka, Fangjia Luo, Kensuke Tono, Kai-Cheng Hsu, Stephan Kiontke, Igor Schapiro, Roberta Spadaccini, Antoine Royant, Junpei Yamamoto, So Iwata, Lars-Oliver Essen, Yoshitaka Bessho, Ming-Daw Tsai

    NATURE CHEMISTRY　Vol. 14　p. 677-685　2022/04　Research paper (scientific journal)

  11. Limited solvation of an electron donating tryptophan stabilizes a photoinduced charge-separated state in plant (6-4) photolyase

    Yuhei Hosokawa, Pavel Müller, Hirotaka Kitoh-Nishioka, Shigenori Iwai, Junpei Yamamoto

    Scientific Reports　Vol. 12　2022/03　Research paper (scientific journal)

  12. Kinetics of electron returns in successive two-photon DNA repair by (6-4) photolyase

    Klaus Brettel, Pavel Müller, Junpei Yamamoto

    ACS Catalysis　Vol. 12　p. 3041-3045　2022/02　Research paper (scientific journal)

  13. Structural Changes during the Photorepair and Binding Processes of Xenopus (6–4) Photolyase with (6–4) Photoproducts in Single- and Double-Stranded DNA

    Daichi Yamada, Junpei Yamamoto, Elizabeth D. Getzoff, Tatsuya Iwata, Hideki Kandori

    Biochemistry　Vol. 60　No. 43　p. 3253-3261　2021/10　Research paper (scientific journal)

    Publisher: American Chemical Society (ACS)

  14. Key interactions with deazariboflavin cofactor for light-driven energy transfer in Xenopus (6–4) photolyase

    Ayaka Morimoto, Yuhei Hosokawa, Hiromu Miyamoto, Rajiv Kumar Verma, Shigenori Iwai, Ryuma Sato, Junpei Yamamoto

    Vol. 20　No. 7　p. 875-887　2021/06　Research paper (scientific journal)

  15. Theoretical insights into the DNA repair function of Arabidopsis thaliana cryptochrome-DASH

    Ryuma Sato, Yoshiharu Mori, Risa Matsui, Noriaki Okimoto, Junpei Yamamoto, Makoto Taiji

    Biophysics and Physicobiology　Vol. 17　No. 0　p. 113-124　2020/09　Research paper (scientific journal)

    Publisher: Biophysical Society of Japan

  16. Enhanced DNA repair by DNA photolyase bearing an artificial light-harvesting chromophore

    Yuma Terai, Ryuma Sato, Risa Matsumura, Shigenori Iwai, Junpei Yamamoto

    Nucleic Acids Research　Vol. 48　No. 18　p. 10076-10086　2020/09　Research paper (scientific journal)

  17. Mutational analysis of Thermococcus kodakarensis endonuclease III reveals the roles of evolutionarily conserved residues

    Miyako Shiraishi, Kento Mizutani, Junpei Yamamoto, Shigenori Iwai

    DNA Repair　Vol. 90　2020/06　Research paper (scientific journal)

  18. Plant organellar DNA polymerases bypass Thymine Glycol using two conserved lysine residues

    Noe Baruch-Torres, Junpei Yamamoto, Victor Juárez-Quintero, Shigenori Iwai, Luis G Brieba

    Biochemical Journal　Vol. 477　No. 5　p. 1049-1059　2020/02　Research paper (scientific journal)

  19. Inhibiting guanine oxidation and enhancing the excess-electron-transfer efficiency of a pyrene-modified oligonucleotide by introducing an electron-donating group on pyrene

    Takumi Okuda, Yusuke Kawashima, Yuuya Kasahara, Tatsuya Takagi, Junpei Yamamoto, Shigenori Iwai, Satoshi Obika

    Chemical Communications　Vol. 55　No. 93　p. 14062-14065　2019/10　Research paper (scientific journal)

    Publisher: Royal Society of Chemistry (RSC)

  20. Implications of a water molecule for photoactivation of plant (6-4) photolyase

    Yuhei Hosokawa, Ryuma Sato, Shigenori Iwai, Junpei Yamamoto

    Journal of Physical Chemistry B　Vol. 123　No. 24　p. 5059-5068　2019/06　Research paper (scientific journal)

  21. DNA damage detection in nucleosomes involves DNA register shifting

    Syota Matsumoto, Simone Cavadini, Richard D. Bunker, Ralph S. Grand, Alessandro Potenza, Julius Rabl, Junpei Yamamoto, Andreas D. Schenk, Dirk Schubeler, Shigenori Iwai, Kaoru Sugasawa, Hitoshi Kurumizaka, Nicolas H. Thoma

    Nature　Vol. 571　p. 79-84　2019/06　Research paper (scientific journal)

  22. Acetaldehyde forms covalent GG intrastrand crosslinks in DNA

    Yuina Sonohara, Junpei Yamamoto, Kosuke Tohashi, Reine Takatsuka, Tomonari Matsuda, Shigenori Iwai, Isao Kuraoka

    Scientific Reports　Vol. 9　No. 1　p. 660-660　2019/01　Research paper (scientific journal)

  23. Twist and turn: a revised structural view on the unpaired bubble of class II CPD photolyase in complex with damaged DNA

    Manuel Maestre-Reyna, Junpei Yamamoto, Wei-Cheng Huang, Ming-Daw Tsai, Lars-Oliver Essen, Yoshitaka Bessho

    IUCrJ　Vol. 5　No. 5　p. 608-618　2018/09　Research paper (scientific journal)

  24. Structure of the bifunctional cryptochrome aCRY from Chlamydomonas reinhardtii

    Sophie Franz, Elisabeth Ignatz, Sandra Wenzel, Hannah Zielosko, Eka Putra, Gusti Ngurah Putu, Manuel Maestre-Reyna, Ming-Daw Tsai, Junpei Yamamoto, Maria Mittag, Lars-Oliver Essen

    Nucleic Acids Research　Vol. 46　No. 15　p. 8010-8022　2018/09　Research paper (scientific journal)

  25. Fluorescence detection of DNA mismatch repair in human cells

    Shunsuke Ito, Miyako Shiraishi, Kazuki Tsuchihashi, Reine Takatsuka, Junpei Yamamoto, Isao Kuraoka, Shigenori Iwai

    Scientific Reports　Vol. 8　2018/08　Research paper (scientific journal)

  26. Coulomb and CH–π interactions in (6–4) photolyase–DNA complex dominate DNA binding and repair abilities

    Yuma Terai, Ryuma Sato, Takahiro Yumiba, Ryuhei Harada, Kohei Shimizu, Tatsuya Toga, Tomoko Ishikawa-Fujiwara, Takeshi Todo, Shigenori Iwai, Yasuteru Shigeta, Junpei Yamamoto

    Nucleic Acids Research　Vol. 46　No. 13　p. 6761-6772　2018/07　Research paper (scientific journal)

  27. Loss of Fourth Electron-Transferring Tryptophan in Animal (6-4) Photolyase Impairs DNA Repair Activity in Bacterial Cells

    Junpei Yamamoto, Kohei Shimizu, Takahiro Kanda, Yuhei Hosokawa, Shigenori Iwai, Pascal Plaza, Pavel Mueller

    BIOCHEMISTRY　Vol. 56　No. 40　p. 5356-5364　2017/10　Research paper (scientific journal)

  28. Ultrafast flavin photoreduction in an oxidized animal (6-4) photolyase through an unconventional tryptophan tetrad

    Ryan Martin, Fabien Lacombat, Agathe Espagne, Nadia Dozova, Pascal Plaza, Junpei Yamamoto, Pavel Mueller, Klaus Brettel, Aurelien de la Lande

    PHYSICAL CHEMISTRY CHEMICAL PHYSICS　Vol. 19　No. 36　p. 24493-24504　2017/09　Research paper (scientific journal)

  29. The dominant role of proofreading exonuclease activity of replicative polymerase epsilon in cellular tolerance to cytarabine (Ara-C)

    Masataka Tsuda, Kazuhiro Terada, Masato Ooka, Koji Kobayashi, Hiroyuki Sasanuma, Ryo Fujisawa, Toshiki Tsurimoto, Junpei Yamamoto, Shigenori Iwai, Kei Kadoda, Remi Akagawa, Shar-Yin Naomi Huang, Yves Pommier, Julian E. Sale, Shunichi Takeda, Kouji Hirota

    ONCOTARGET　Vol. 8　No. 20　p. 33457-33474　2017/05　Research paper (scientific journal)

  30. Post-synthetic Modification of 3 ' Terminus of RNA with Propargylamine: A Versatile Scaffold for RNA Labeling through Copper-catalyzed Azide-Alkyne Cycloaddition

    Junpei Yamamoto, Shohei Ebisuda, Lingqi Kong, Haruka Yamago, Shigenori Iwai

    CHEMISTRY LETTERS　Vol. 46　No. 5　p. 767-770　2017/05　Research paper (scientific journal)

  31. Functional Conversion of CPD and (6-4) Photolyases by Mutation

    Daichi Yamada, Hisham M. Dokainish, Tatsuya Iwata, Junpei Yamamoto, Tomoko Ishikawa, Takeshi Todo, Shigenori Iwai, Elizabeth D. Getzoff, Akio Kitao, Hideki Kandori

    BIOCHEMISTRY　Vol. 55　No. 30　p. 4173-4183　2016/08　Research paper (scientific journal)

  32. Chemical Incorporation of Chain-Terminating Nucleoside Analogs as 3 '-Blocking DNA Damage and Their Removal by Human ERCC1-XPF Endonuclease

    Junpei Yamamoto, Chiaki Takahata, Isao Kuraoka, Kouji Hirota, Shigenori Iwai

    MOLECULES　Vol. 21　No. 6　2016/06　Research paper (scientific journal)

  33. Structural Changes of the Active Center during the Photoactivation of Xenopus (6-4) Photolyase

    Daichi Yamada, Junpei Yamamoto, Yu Zhang, Tatsuya Iwata, Kenichi Hitomi, Elizabeth D. Getzoff, Shigenori Iwai, Hideki Kandori

    BIOCHEMISTRY　Vol. 55　No. 4　p. 715-723　2016/02　Research paper (scientific journal)

  34. Repriming by PrimPol is critical for DNA replication restart downstream of lesions and chain-terminating nucleosides

    Kaori Kobayashi, Thomas A. Guilliam, Masataka Tsuda, Junpei Yamamoto, Laura J. Bailey, Shigenori Iwai, Shunichi Takeda, Aidan J. Doherty, Kouji Hirota

    CELL CYCLE　Vol. 15　No. 15　p. 1997-2008　2016　Research paper (scientific journal)

  35. Structural role of two histidines in the (6-4) photolyase reaction

    Daichi Yamada, Tatsuya Iwata, Junpei Yamamoto, Kenichi Hitomi, Takeshi Todo, Shigenori Iwai, Elizabeth D. Getzoff, Hideki Kandori

    Biophysics and Physicobiology　Vol. 12　p. 139-144　2015/12　Research paper (scientific journal)

  36. Structural basis of pyrimidine-pyrimidone (6-4) photoproduct recognition by UV-DDB in the nucleosome.

    Akihisa Osakabe, Hiroaki Tachiwana, Wataru Kagawa, Naoki Horikoshi, Syota Matsumoto, Mayu Hasegawa, Naoyuki Matsumoto, Tatsuya Toga, Junpei Yamamoto, Fumio Hanaoka, Nicolas H Thomä, Kaoru Sugasawa, Shigenori Iwai, Hitoshi Kurumizaka

    Scientific reports　Vol. 5　p. 16330-16330　2015/11/17　Research paper (scientific journal)

  37. Abacavir, an anti-HIV-1 drug, targets TDP1-deficient adult T cell leukemia

    Kohei Tada, Masayuki Kobayashi, Yoko Takiuchi, Fumie Iwai, Takashi Sakamoto, Kayoko Nagata, Masanobu Shinohara, Katsuhiro Io, Kotaro Shirakawa, Masakatsu Hishizawa, Keisuke Shindo, Norimitsu Kadowaki, Kouji Hirota, Junpei Yamamoto, Shigenori Iwai, Hiroyuki Sasanuma, Shunichi Takeda, Akifumi Takaori-Kondo

    SCIENCE ADVANCES　Vol. 1　No. 3　2015/04　Research paper (scientific journal)

  38. Analysis of Structural Flexibility of Damaged DNA Using Thiol-Tethered Oligonucleotide Duplexes

    Masashi Fujita, Shun Watanabe, Mariko Yoshizawa, Junpei Yamamoto, Shigenori Iwai

    PLOS ONE　Vol. 10　No. 2　2015/02　Research paper (scientific journal)

  39. Ftir study of CPD photolyase with substrate in single strand DNA

    I. M. Mahaputra Wijaya, Tatsuya Iwata, Junpei Yamamoto, Kenichi Hitomi, Shigenori Iwai, Elizabeth D. Getzoff, Hideki Kandori

    Biophysics (Japan)　Vol. 11　p. 39-45　2015　Research paper (scientific journal)

    Publisher: Biophysical Society of Japan

  40. Analysis of ATP and AMP binding to a DNA aptamer and its imidazole-tethered derivatives by surface plasmon resonance

    Jing Zhao, Satoshi Katsube, Junpei Yamamoto, Kazuhiko Yamasaki, Makoto Miyagishi, Shigenori Iwai

    ANALYST　Vol. 140　No. 17　p. 5881-5884　2015　Research paper (scientific journal)

  41. Discovery and functional analysis of a 4th electron-transferring tryptophan conserved exclusively in animal cryptochromes and (6-4) photolyases

    Pavel Mueller, Junpei Yamamoto, Ryan Martin, Shigenori Iwai, Klaus Brettel

    CHEMICAL COMMUNICATIONS　Vol. 51　No. 85　p. 15502-15505　2015　Research paper (scientific journal)

  42. Flavin Adenine Dinucleotide Chromophore Charge Controls the Conformation of Cyclobutane Pyrimidine Dimer Photolyase alpha-Helices

    I. M. Mahaputra Wijaya, Tatsuya Iwata, Junpei Yamamoto, Kenichi Hitomi, Shigenori Iwai, Elizabeth D. Getzoff, John T. M. Kennis, Tilo Mathes, Hideki Kandori

    BIOCHEMISTRY　Vol. 53　No. 37　p. 5864-5875　2014/09　Research paper (scientific journal)

  43. A cyclobutane thymine-N4-methylcytosine dimer is resistant to hydrolysis but strongly blocks DNA synthesis.

    Junpei Yamamoto, Tomoko Oyama, Tomohiro Kunishi, Chikahide Masutani, Fumio Hanaoka, Shigenori Iwai

    Nucleic acids research　Vol. 42　No. 3　p. 2075-84　2014/02　Research paper (scientific journal)

  44. Deformable nature of various damaged DNA duplexes estimated by an electrochemical analysis on electrodes

    J. Chiba, S. Aoki, J. Yamamoto, S. Iwai, M. Inouye

    CHEMICAL COMMUNICATIONS　Vol. 50　No. 76　p. 11126-11128　2014　Research paper (scientific journal)

  45. Repair of the (6-4) Photoproduct by DNA Photolyase Requires Two Photons

    Junpei Yamamoto, Ryan Martin, Shigenori Iwai, Pascal Plaza, Klaus Brettel

    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION　Vol. 52　No. 29　p. 7432-7436　2013/07　Research paper (scientific journal)

  46. Detection of Distinct alpha-Helical Rearrangements of Cyclobutane Pyrimidine Dimer Photolyase upon Substrate Binding by Fourier Transform Infrared Spectroscopy

    I. M. Mahaputra Wijaya, Yu Zhang, Tatsuya Iwata, Junpei Yamamoto, Kenichi Hitomi, Shigenori Iwai, Elizabeth D. Getzoff, Hideki Kandori

    BIOCHEMISTRY　Vol. 52　No. 6　p. 1019-1027　2013/02　Research paper (scientific journal)

  47. Strand breakage of a (6-4) photoproduct-containing DNA at neutral pH and its repair by the ERCC1-XPF protein complex

    Norihito Arichi, Junpei Yamamoto, Chiaki Takahata, Emi Sano, Yuji Masuda, Isao Kuraoka, Shigenori Iwai

    ORGANIC & BIOMOLECULAR CHEMISTRY　Vol. 11　No. 21　p. 3526-3534　2013　Research paper (scientific journal)

  48. Effects of 5 ',8-Cyclodeoxyadenosine Triphosphates on DNA Synthesis

    Naoto Kamakura, Junpei Yamamoto, Philip J. Brooks, Shigenori Iwai, Isao Kuraoka

    CHEMICAL RESEARCH IN TOXICOLOGY　Vol. 25　No. 12　p. 2718-2724　2012/12　Research paper (scientific journal)

  49. Eukaryotic Class II Cyclobutane Pyrimidine Dimer Photolyase Structure Reveals Basis for Improved Ultraviolet Tolerance in Plants

    Kenichi Hitomi, Andrew S. Arvai, Junpei Yamamoto, Chiharu Hitomi, Mika Teranishi, Tokuhisa Hirouchi, Kazuo Yamamoto, Shigenori Iwai, John A. Tainer, Jun Hidema, Elizabeth D. Getzoff

    JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 287　No. 15　p. 12060-12069　2012/04　Research paper (scientific journal)

  50. Mechanism of the alkali degradation of (6-4) photoproduct-containing DNA

    Norihito Arichi, Aki Inase, Sachise Eto, Toshimi Mizukoshi, Junpei Yamamoto, Shigenori Iwai

    ORGANIC & BIOMOLECULAR CHEMISTRY　Vol. 10　No. 11　p. 2318-2325　2012　Research paper (scientific journal)

  51. Substrate Assignment of the (6-4) Photolyase Reaction by FTIR Spectroscopy

    Yu Zhang, Junpei Yamamoto, Daichi Yamada, Tatsuya Iwata, Kenichi Hitomi, Takeshi Todo, Elizabeth D. Getzoff, Shigenori Iwai, Hideki Kandorit

    JOURNAL OF PHYSICAL CHEMISTRY LETTERS　Vol. 2　No. 21　p. 2774-2777　2011/11　Research paper (scientific journal)

  52. FTIR Study of Light-Dependent Activation and DNA Repair Processes of (6-4) Photolyase

    Yu Zhang, Tatsuya Iwata, Junpei Yamamoto, Kenichi Hitomi, Shigenori Iwai, Takeshi Todo, Elizabeth D. Getzoff, Hideki Kandori

    BIOCHEMISTRY　Vol. 50　No. 18　p. 3591-3598　2011/05　Research paper (scientific journal)

  53. Light-Induced Conformational Change and Product Release in DNA Repair by (6-4) Photolyase

    Masato Kondoh, Kenichi Hitomi, Junpei Yamamoto, Takeshi Todo, Shigenori Iwai, Elizabeth D. Getzoff, Masahide Terazima

    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY　Vol. 133　No. 7　p. 2183-2191　2011/02　Research paper (scientific journal)

  54. Photosensitized [2 + 2] cycloaddition of N-acetylated cytosine affords stereoselective formation of cyclobutane pyrimidine dimer.

    Junpei Yamamoto, Kosuke Nishiguchi, Koichiro Manabe, Chikahide Masutani, Fumio Hanaoka, Shigenori Iwai

    Nucleic acids research　Vol. 39　No. 3　p. 1165-75　2011/02　Research paper (scientific journal)

  55. Human replicative DNA polymerase delta can bypass T-T (6-4) ultraviolet photoproducts on template strands

    Takeo Narita, Toshiki Tsurimoto, Junpei Yamamoto, Kana Nishihara, Kaori Ogawa, Eiji Ohashi, Terry Evans, Shigenori Iwai, Shunichi Takeda, Kouji Hirota

    GENES TO CELLS　Vol. 15　No. 12　p. 1228-1239　2010/12　Research paper (scientific journal)

  56. Role of the carbonyl group of the (6-4) photoproduct in the (6-4) photolyase reaction

    Junpei Yamamoto, Kenichi Hitomi, Ryosuke Hayashi, Elizabeth D. Getzoff, Shigenori Iwai

    BIOCHEMISTRY　Vol. 48　No. 39　p. 9306-9312　2009/10　Research paper (scientific journal)

  57. Functional motifs in the (6-4) photolyase crystal structure make a comparative framework for DNA repair photolyases and clock cryptochromes

    Kenichi Hitomi, Luciano DiTacchio, Andrew S. Arvai, Junpei Yamamoto, Sang-Tae Kim, Takeshi Todo, John A. Tainer, Shigenori Iwai, Satchidananda Panda, Elizabeth D. Getzoff

    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　Vol. 106　No. 17　p. 6962-6967　2009/04　Research paper (scientific journal)

  58. Efficient conversion of thymine glycol into the formamide lesion in oligonucleotides

    Tatsuya Toga, Junpei Yamamoto, Shigenori Iwai

    TETRAHEDRON LETTERS　Vol. 50　No. 6　p. 723-726　2009/02　Research paper (scientific journal)

  59. Spectroscopic analysis of the pyrimidine(6-4)pyrimidone photoproduct: insights into the (6-4) photolyase reaction

    Junpei Yamamoto, Yoshiyuki Tanaka, Shigenori Iwai

    ORGANIC & BIOMOLECULAR CHEMISTRY　Vol. 7　No. 1　p. 161-166　2009　Research paper (scientific journal)

  60. Chemical synthesis of oligodeoxyribonucleotides containing the Dewar valence isomer of the (6-4) photoproduct and their use in (6-4) photolyase studies

    Junpei Yamamoto, Kenichi Hitomi, Takeshi Todo, Shigenori Iwai

    NUCLEIC ACIDS RESEARCH　Vol. 34　No. 16　p. 4406-4415　2006/09　Research paper (scientific journal)

Misc. 9

  1. Dynamic control of sequential electron and proton transfer events in a flavoenzyme captured at SACLA

    SPring-8/SACLA Information　Vol. 28　No. 2　p. 113-118　2023/05　Article, review, commentary, editorial, etc. (bulletin of university, research institution)

  2. Theoretical Analyses for DNA Repair Function of Cryptochrome-DASH

    佐藤竜馬, 森義治, 松井理紗, 沖本憲明, 山元淳平, 泰地真弘人

    生物物理(Web)　Vol. 62　No. 2　2022

  3. (6–4)光回復酵素によるDNA認識および修復機構

    山元淳平

    日本核酸化学会誌　Vol. 2　p. 21-25　2018/11　Article, review, commentary, editorial, etc. (scientific journal)

  4. Repair of (6-4) Lesions in DNA by (6-4) Photolyase: 20 Years of Quest for the Photoreaction Mechanism

    Junpei Yamamoto, Pascal Plaza, Klaus Brettel

    PHOTOCHEMISTRY AND PHOTOBIOLOGY　Vol. 93　No. 1　p. 51-66　2017/01　Book review, literature introduction, etc.

  5. A proposal for a novel DNA repair mechanism by the (6-4) photolyase

    Junpei Yamamoto

    Radiation Biology Research Communications　Vol. 50　No. 2　p. 174-184　2015/05　Article, review, commentary, editorial, etc. (scientific journal)

  6. (6-4)光回復酵素による 2光子DNA修復の分子メカニズム

    山元淳平

    生物物理　Vol. 55　No. 3　p. 157-158　2015/05　Article, review, commentary, editorial, etc. (scientific journal)

  7. Recognition and reaction mechanisms of the (6-4) photolyase as determined by using a (6-4) photoproduct analog.

    Junpei Yamamoto, Kenichi Hitomi, Ryosuke Hayashi, Elizabeth D Getzoff, Shigenori Iwai

    Nucleic acids symposium series (2004)　No. 53　p. 221-222　2009

  8. Spectroscopic studies on a novel intramolecular hydrogen bond within the (6-4) photoproduct

    Junpei Yamamoto, Yoshiyuki Tanaka, Kenichi Hitomi, Elizabeth D. Getzoff, Shigenori Iwai

    Nucleic Acids Symposium Series　Vol. 51　p. 79-80　2007

  9. Synthesis of oligonucleotides containing the Dewar valence isomer of the (6-4) photoproduct and their application to (6-4) photolyase studies.

    Junpei Yamamoto, Kenichi Hitomi, Takeshi Todo, Shigenori Iwai

    Nucleic acids symposium series (2004)　No. 50　p. 61-62　2006

Presentations 43

  1. Time-resolved crystallography reveals structural transitions of a bifunctional cryptochrome bearing a light-harvesting antenna chromophore

    Junpei Yamamoto, Wei-Tin Lin, Meng-Iao Fong, Kai-Chun Yang, Hikaru Saito, Yuhei Hosokawa, Manuel Maestre-Reyna

    第63回日本生物物理学会年会　2025/09/24

  2. Cinematography of enzymatic reactions at atomic resolutions

    Junpei Yamamoto

    The 4th UK-Japan Frontier of Science Symposium　2025/06/19

  3. Profiling of i-motif-binding proteins via fingerprint-targeting enrichment

    Junpei Yamamoto

    Nucleic Acids Secondary Structures: G4s and beyond　2025/03/27

  4. Enhanced light-driven DNA repair by a photolyase bearing an artificial light-harvesting chromophore

    Junpei Yamamoto

    The 18th International Congress on Photobiology　2024/08/26

  5. Visualizing the DNA repair process by DNA photolyase at attic resolution via time-resolved serial femtosecond X-ray crystallography

    Junpei Yamamoto, Manuel Maestre-Reyna, Yoshitaka Bessho, Lars-Oliver Essen, Ming-Daw Tsai

    Supra FIBER International Summit for Nucleic Acids　2024/03/01

  6. 時分割シリアルフェムト秒X線結晶構造解析によるDNA光回復酵素の全修復過程の原子分解能観測

    山元淳平, Manuel Maestre-Reyna, 別所義隆, Lars-Oliver Essen, Ming-Daw Tsai

    日本放射線影響学会第66回年次大会　2023/11/08

  7. 時分割X線結晶構造解析で捉えたDNA光回復酵素によるDNA修復過程

    山元淳平, Manuel Maestre-Reyna, 別所義隆, Lars-Oliver Essen, 蔡明道

    第23回日本光生物学協会年会　2023/08/30

  8. 二元機能性動物類縁型クリプトクロムの 光活性化過程の動的構造解析

    山元淳平

    令和5年度新学術領域研究「高速分子動画」シンポジウム　2023/05/10

  9. 放射光レーザーを用いた生体分子時分割構造解析のイマとミライ

    山元淳平

    創発の場 -フォトニクス討論会- in 徳島　2022/09/02

  10. (6-4)光回復酵素による逐次2光子DNA修復反応の時間領域の決定

    山元淳平, Klaus Brettel, Pavel MÜLLER

    第48回生体分子科学討論会　2022/07/01

  11. (6-4)光回復酵素によるDNA修復過程の捕捉に向けて

    山元淳平

    令和三年度 新学術領域研究「高速分子動画」シンポジウム　2021/11/01

  12. ゲノム恒常性維持における量子性:青色光受容タンパク質による逐次2光子DNA修復

    山元淳平

    量子生命科学会 第２回大会　2020/12/24

  13. 人工集光アンテナ分子修飾による光回復酵素のDNA修復能の向上

    寺井悠馬, 川上由夏, 佐藤竜馬, 岩井成憲, 山元淳平

    第14回バイオ関連化学シンポジウム　2020/09/07

  14. 集光クマリン色素を有するDNA光回復酵素による高効率光駆動DNA修復

    Yuma Terai, Ryuma Sato, Risa Matsumura, Shigenori Iwai, Junpei Yamamoto

    第57回日本生物物理学会年会　2019/09/24

  15. Facile post-synthetic functionalization of 3' terminus of DNA with alkyne and thiol

    Junpei Yamamoto, Tatsuya Yajima, Shigenori Iwai

    Commemorative International Symposium of the Japan Society of Nucleic Acids Chemistry 2019　2019/07/23

  16. (6-4)光回復酵素のDNA分子認識・修復機構

    山元淳平

    日本放射線影響学会 第６１回大会　2018/11/08

  17. DNA binding and light-dependent DNA repair abilities of photolyases

    Junpei Yamamoto

    第56回日本生物物理学会年会　2018/09/17

  18. Coulomb and CH–π interactions in DNA-photolyase complex dominate DNA binding and repair abilities

    Yuma Terai, Ryuma Sato, Takahiro Yumiba, Ryuhei Harada, Shigenori Iwai, Yasuteru Shigeta, Junpei Yamamoto

    第12回バイオ関連化学シンポジウム　2018/09/09

  19. Post synthetic modification of 3'-terminus of DNA for universal labeling

    Junpei Yamamoto, Tatsuya Yajima, Shigenori Iwai

    The 44th International Symposium on Nucleic Acids Chemistry　2017/11/14

  20. An arginine side chain in the (6-4) photolyase governs formation of a robust repair-active complex with UV-damaged DNA

    Junpei Yamamoto, Yuma Terai, Ryuma Sato, Ryuhei Harada, Yasuteru Shigeta, Shigenori Iwai

    第55回日本生物物理学会年会　2017/09/19

  21. Monitoring of the back electron transfer in the successive two-photon DNA repair by the (6-4) photolyase

    Junpei Yamamoto, Kohei Shimizu, Shigenori Iwai, Klaus Brettel

    第54回日本生物物理学会年会　2016/11/26

  22. Post-synthetic conjugation of propargylamine at the 3' terminus of RNA: a versatile scaffold for RNA modification by copper-catalyzed alkyne-azide cycloaddition

    Junpei Yamamoto, Shohei Ebisuda, Shigenori Iwai

    The 43rd International Symposium on Nucleic Acids Chemistry　2016/09/27

  23. Molecular mechanism of the successive two-photon DNA repair by the (6-4) photolyase

    Junpei Yamamoto, Kohei Shimizu, Klaus Brettel, Shigenori Iwai

    2016/03/24

  24. Human ERCC1-XPF endonuclease removes chain-terminating nucleoside analogs in DNA

    Junpei Yamamoto, Chiaki Takahata, Isao Kuraoka, Kouji Hirota, Shigenori Iwai

    BMB2015　2015/12/01

  25. Removal of chain-terminating nucleoside analogues in DNA by human ERCC1-XPF endonuclease

    Junpei Yamamoto, Chiaki Takahata, Isao Kuraoka, Kouji Hirota, Shigenori Iwai

    The 42nd International Symposium on Nucleic Acid Chemistry　2015/09/26

  26. An expanded electron transfer pathway in the (6-4) photolyase

    Junpei Yamamoto, Pavel Muller, Kohei Shimizu, Klaus Brettel, Shigenori Iwai

    第53回日本生物物理学会年会　2015/09/13

  27. Synthesis of oligonucleotides containing chain-terminating antiviral drugs and their use in biochemical analyses

    Junpei Yamamoto, Shigenori Iwai

    The 41th International Symposium on Nucleic Acids Chemistry　2014/11/06

  28. Molecular mechanism of the two photon DNA repair by the (6-4) photolyas

    Junpei Yamamoto, Kohei Shimizu, Tomoko Fujiwara, Takeshi Todo, Pascal Plaza, Klaus Brettel, Shigenori Iwai

    2014/09/25

  29. 抗ウイルス剤を末端に有するオリゴヌクレオチドの合成とそれを用いた生化学解析

    山元淳平, 岩井成憲

    第8回バイオ関連化学シンポジウム　2014/09/11

  30. 紫外線損傷DNAの化学合成及びその修復反応・変異機構解析

    山元淳平

    変異機構研究会第27回夏の学校　2014/06/21

  31. Biochemical and thermodynamic properties of a cyclobutane thymine-N4-methylcytosine dimer

    Junpei Yamamoto, Tomoko Oyama, Tomohiro Kunishi, Shigenori Iwai

    The 40th International Symposium on Nucleic Acids Chemistry　2013/11/13

  32. A two photon DNA repair mechanism of the (6-4) photolyase

    Junpei Yamamoto, Ryan Martin, Shigenori Iwai, Pascal Plaza, Klaus Brettel

    2013/10/28

  33. シトシン塩基由来シクロブタン型紫外線損傷DNAの安定アナログの合成とその性質

    山元淳平, 小山智子, 國司知宏, 岩井成憲

    日本化学会第93春季年会　2013/03/24

  34. 紫外線損傷DNAにおける光回復酵素系の役割

    山元淳平

    太陽紫外線防御研究委員会第23回シンポジウム　2013/03/15

  35. Recognition and repair of the (6-4) photoproduct by DNA photolyase

    Junpei Yamamoto, Ryan Martin, Shigenori Iwai, Pascal Plaza, Klaus Brettel

    The 39th International Symposium on Nucleic Acids Chemistry　2012/11/15

  36. (6-4)光回復酵素による紫外線損傷DNA修復反応機構

    2012/09/06

  37. (6-4)光回復酵素による紫外線損傷DNA修復反応機構

    山元淳平, Ryan Martin, 岩井成憲, Pascal Plaza, Klaus Brettel

    第17回光生物学協会年会　2012/08/18

  38. 化学合成基質アナログの構造活性相関解析による(6-4)光回復酵素の基質認識・修復反応機構解析

    山元淳平, 藤堂剛, 岩井成憲

    第16回光生物学協会年会　2010/08/10

  39. DNA化学合成のためのシクロブタン型紫外線損傷の立体選択的形成

    山元淳平, 西口浩佑, 岩井成憲

    日本化学会第90春季年会　2010/03/28

  40. Recognition and reaction mechanism of the (6-4) photolyase as determined by using a (6-4) photoproduct analog

    Junpei Yamamoto, Kenichi Hitomi, Ryosuke Hayashi, Elizabeth D. Getzoff, Shigenori Iwai

    The 6th International Symposium on Nucleic Acids Chemistry　2009/09/28

  41. Translesion synthesis across the (6-4) photoproduct and its Dewar valence isomer by the Y-family and engineered DNA polymerases

    Junpei Yamamoto, David Roakes, Chikahide Masutani, Shizu Simmyo, Kumiko Urabe, Fumio Hanaoka, Philipp Holliger, Shigenori Iwai

    Joint Symposium of the 18th International Roundtable on Nucleosides, Nucleotides, and Nucleic Acids and the 35th International Symposium on Nucleic Acids Chemistry　2008/09/09

  42. Spectroscopic studies on a novel intramolecular hydrogen bond within the (6-4) photoproduct

    Junpei Yamamoto, Yoshiyuki Tanaka, Kenichi Hitomi, Elizabeth D. Getzoff, Shigenori Iwai

    The 5th International Symposium on Nucleic Acids Chemistry　2007/11/20

  43. A novel photodamage recognition mechanisms for eukaryotic CPD photolyase

    Junpei Yamamoto, Kenichi Hitomi, Andrew S. Arvai, John A. Tainer, Kazuo Yamamoto, Mika Teranishi, Jun Hidema, Tadashi Kumagai, Tomoko Ishikawa, Takeshi Todo, Elizabeth D. Getzoff, Shigenori Iwai

    The 4th International 3R (DNA Replication, Recombination, and Repair) Symposium　2005/11/16

Social Activities 6

  • 構造生物学のフロンティアーDNA修復反応の直接検出に向けてー

    大阪大学基礎工学部　第43回公開講座

    2022/08/03 - 2022/08/05

  • 大阪府立天王寺高等学校SSH研究指導

    2012/10 - 2013/03

  • 化学スーパーレッスン

    大阪府立天王寺高等学校

    2013/02/06 - 2013/02/06

  • サイエンスカフェ＠待兼山

    2009/10/31 - 2009/10/31

  • 構造生物学のフロンティア

    大阪大学SEEDSプログラム　2022年体感科学技術

    2022/08/06 -

  • SSセミナー「化学の言葉で紡ぐ生命現象への誘い」

    高槻高校

    2020/10/02 -

Media Coverage 1

  1. ぶらっとラボ「光で治せ、紫外線由来の病気」

    2020/10/26

Institutional Repository 3

Content Published in the University of Osaka Institutional Repository (OUKA)

  1. Profiling of i-motif-binding proteins reveals functional roles of nucleolin in regulation of high-order DNA structures

    Ban Yuki, Ando Yuka, Terai Yuma, Matsumura Risa, Nakane Keita, Iwai Shigenori, Sato Shinichi, Yamamoto Junpei

    Nucleic Acids Research　Vol. 52　No. 22　p. 13530-13543　2024/11/19

  2. A deazariboflavin chromophore kinetically stabilizes reduced FAD state in a bifunctional cryptochrome

    Hosokawa Yuhei, Morita Hiroyoshi, Nakamura Mai, Yamamoto Junpei

    Scientific Reports　Vol. 13　No. 1　2023/10/04

  3. Studies on Synthesis of UV-Damaged DNA and Its Application to DNA Repair by Photolyase

    山元 淳平