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Yamamoto Jumpei

山元　淳平

Graduate School of Engineering Science　Department of Materials Engineering Science, Associate Professor

keyword Photobiology，Nucleic Acids Chemistry，Photolyase，DNA damage，DNA repair

Education

  • 2005/04 - 2009/09, Osaka University, Graduate School of Engineering Science, Department of Materials Engineering Science Division of Chemistry
  • 2001/04 - 2005/03, Osaka University, School of Engineering Science Direct Affiliates, Department of Chemical Sciece and Engineering

Research History

  • 2021/04 - Present, JST創発的研究支援事業, 研究者
  • 2019/07 - Present, Graduate School of Engineering Science, Associate Professor
  • 2017/04 - 2019/06, Osaka University, Graduate School of Engineering Science, Lecturer
  • 2009/10 - 2017/03, Osaka University, Graduate School of Engineering Science, Asistant professor
  • 2014/09 - 2014/11, CEA Saclay, Visiting researcher
  • 2011/03 - 2012/02, Ecole Normale Superieure Paris, Visiting researcher
  • 2008/04 - 2009/09, Japan Society for the Promotion of Science

Research Areas

  • Life sciences, Functional biochemistry
  • Nanotechnology/Materials, Biochemistry
  • Life sciences, Biophysics

Professional Memberships

  • THE JAPAN SOCIETY OF NUCLEIC ACIDS CHEMISTRY
  • THE BIOPHYSICAL SOCIETY OF JAPAN
  • THE MOLECULAR BIOLOGY SOCIETY OF JAPAN
  • THE CHEMICAL SOCIETY OF JAPAN

Papers

  • Visualizing the DNA repair process by a photolyase at atomic resolution, Manuel Maestre-Reyna,Po-Hsun Wang,Eriko Nango,Yuhei Hosokawa,Martin Saf,Antonia Furrer,Cheng-Han Yang,Eka Putra,Gusti Ngurah Putu,Wen-Jin Wu,Hans-Joachim Emmerich,Nicolas Caramello,Sophie Franz-Badur,Chao Yang,Sylvain Engilberge,Maximilian Wranik,Hannah Louise Glover,Tobias Weiner,Hsiang-Yi Wu,Cheng-Chung Lee,Wei-Cheng Huang,Kai-Fa Huang,Yao-Kai Chang,Jiahn-Haur Liao,Jui-Hung Weng,Wael Gad,Chiung-Wen Chang,Allan H. Pang,Kai-Chun Yang,Wei-Ting Lin,Yu-Chen Chang,Dardan Gashi,Emma Beale,Dmitry Ozerov,Karol Nass,Gregor Knopp,Philip J. M. Johnson,Claudio Cirelli,Chris Milne,Camila Bacellar,Michihiro Sugahara,Shigeki Owada,Yasumasa Joti,Ayumi Yamashita,Rie Tanaka,Tomoyuki Tanaka,Fangjia Luo,Kensuke Tono,Wiktoria Zarzycka,Pavel Müller,Maisa Alkheder Alahmad,Filipp Bezold,Valerie Fuchs,Petra Gnau,Stephan Kiontke,Lukas Korf,Viktoria Reithofer,Christian Joshua Rosner,Elisa Marie Seiler,Mohamed Watad,Laura Werel,Roberta Spadaccini,Junpei Yamamoto,So Iwata,Dongping Zhong,Joerg Standfuss,Antoine Royan,Yoshitaka Bessho,Lars-Oliver Essen,Ming-Daw Tsai, Science, Vol. 382, 2023/12
  • A deazariboflavin chromophore kinetically stabilizes reduced FAD state in a bifunctional cryptochrome, Yuhei Hosokawa,Hiroyoshi Morita,Mai Nakamura,Junpei Yamamoto, Scientific Reports, Vol. 13, 2023/10
  • Repair of topoisomerase 1-induced DNA damage by tyrosyl-DNA phosphodiesterase 2 (TDP2) is dependent on its magnesium binding, Naoto Shimizu,Yusaku Hamada,Ryosuke Morozumi,Junpei Yamamoto,Shigenori Iwai,Kei-ichi Sugiyama,Hiroshi Ide,Masataka Tsuda, Journal of Biological Chemistry, Elsevier BV, p. 104988-104988, 2023/06
  • Serial crystallography captures dynamic control of sequential electron and proton transfer events in a flavoenzyme, Manuel Maestre-Reyna,Cheng-Han Yang,Eriko Nango,Wei-Cheng Huang,Eka Putra Gusti Ngurah Putu,Wen-Jin Wu,Po-Hsun Wang,Sophie Franz-Badur,Martin Saft,Hans-Joachim Emmerich,Hsiang-Yi Wu,Cheng-Chung Lee,Kai-Fa Huang,Yao-Kai Chang,Jiahn-Haur Liao,Jui-Hung Weng,Wael Gad,Chiung-Wen Chang,Allan H. Pang,Michihiro Sugahara,Shigeki Owada,Yuhei Hosokawa,Yasumasa Joti,Ayumi Yamashita,Rie Tanaka,Tomoyuki Tanaka,Fangjia Luo,Kensuke Tono,Kai-Cheng Hsu,Stephan Kiontke,Igor Schapiro,Roberta Spadaccini,Antoine Royant,Junpei Yamamoto,So Iwata,Lars-Oliver Essen,Yoshitaka Bessho,Ming-Daw Tsai, NATURE CHEMISTRY, NATURE PORTFOLIO, Vol. 14, p. 677-685, 2022/04
  • Limited solvation of an electron donating tryptophan stabilizes a photoinduced charge-separated state in plant (6-4) photolyase, Yuhei Hosokawa,Pavel Müller,Hirotaka Kitoh-Nishioka,Shigenori Iwai,Junpei Yamamoto, Scientific Reports, Vol. 12, 2022/03
  • Kinetics of electron returns in successive two-photon DNA repair by (6-4) photolyase, Klaus Brettel,Pavel Müller,Junpei Yamamoto, ACS Catalysis, Vol. 12, p. 3041-3045, 2022/02
  • Structural Changes during the Photorepair and Binding Processes of Xenopus (6–4) Photolyase with (6–4) Photoproducts in Single- and Double-Stranded DNA, Daichi Yamada,Junpei Yamamoto,Elizabeth D. Getzoff,Tatsuya Iwata,Hideki Kandori, Biochemistry, American Chemical Society (ACS), Vol. 60, No. 43, p. 3253-3261, 2021/10
  • Key interactions with deazariboflavin cofactor for light-driven energy transfer in Xenopus (6–4) photolyase, Ayaka Morimoto,Yuhei Hosokawa,Hiromu Miyamoto,Rajiv Kumar Verma,Shigenori Iwai,Ryuma Sato,Junpei Yamamoto, Vol. 20, No. 7, p. 875-887, 2021/06
  • Theoretical insights into the DNA repair function of <i>Arabidopsis thaliana</i> cryptochrome-DASH, Ryuma Sato,Yoshiharu Mori,Risa Matsui,Noriaki Okimoto,Junpei Yamamoto,Makoto Taiji, Biophysics and Physicobiology, Biophysical Society of Japan, Vol. 17, No. 0, p. 113-124, 2020/09
  • Enhanced DNA repair by DNA photolyase bearing an artificial light-harvesting chromophore, Yuma Terai,Ryuma Sato,Risa Matsumura,Shigenori Iwai,Junpei Yamamoto, Nucleic Acids Research, Vol. 48, No. 18, p. 10076-10086, 2020/09
  • Mutational analysis of Thermococcus kodakarensis endonuclease III reveals the roles of evolutionarily conserved residues, Miyako Shiraishi,Kento Mizutani,Junpei Yamamoto,Shigenori Iwai, DNA Repair, Vol. 90, 2020/06
  • Plant organellar DNA polymerases bypass Thymine Glycol using two conserved lysine residues, Noe Baruch-Torres,Junpei Yamamoto,Victor Juárez-Quintero,Shigenori Iwai,Luis G Brieba, Biochemical Journal, Vol. 477, No. 5, p. 1049-1059, 2020/02
  • Inhibiting guanine oxidation and enhancing the excess-electron-transfer efficiency of a pyrene-modified oligonucleotide by introducing an electron-donating group on pyrene, Takumi Okuda,Yusuke Kawashima,Yuuya Kasahara,Tatsuya Takagi,Junpei Yamamoto,Shigenori Iwai,Satoshi Obika, Chemical Communications, Royal Society of Chemistry (RSC), Vol. 55, No. 93, p. 14062-14065, 2019/10
  • Implications of a water molecule for photoactivation of plant (6-4) photolyase, Yuhei Hosokawa,Ryuma Sato,Shigenori Iwai,Junpei Yamamoto, Journal of Physical Chemistry B, Vol. 123, No. 24, p. 5059-5068, 2019/06
  • DNA damage detection in nucleosomes involves DNA register shifting, Syota Matsumoto,Simone Cavadini,Richard D. Bunker,Ralph S. Grand,Alessandro Potenza,Julius Rabl,Junpei Yamamoto,Andreas D. Schenk,Dirk Schubeler,Shigenori Iwai,Kaoru Sugasawa,Hitoshi Kurumizaka,Nicolas H. Thoma, Nature, Vol. 571, p. 79-84, 2019/06
  • Acetaldehyde forms covalent GG intrastrand crosslinks in DNA, Yuina Sonohara,Junpei Yamamoto,Kosuke Tohashi,Reine Takatsuka,Tomonari Matsuda,Shigenori Iwai,Isao Kuraoka, Scientific Reports, Vol. 9, No. 1, p. 660-660, 2019/01
  • Twist and turn: a revised structural view on the unpaired bubble of class II CPD photolyase in complex with damaged DNA, Manuel Maestre-Reyna,Junpei Yamamoto,Wei-Cheng Huang,Ming-Daw Tsai,Lars-Oliver Essen,Yoshitaka Bessho, IUCrJ, Vol. 5, No. 5, p. 608-618, 2018/09
  • Structure of the bifunctional cryptochrome aCRY from Chlamydomonas reinhardtii, Sophie Franz,Elisabeth Ignatz,Sandra Wenzel,Hannah Zielosko,Eka Putra,Gusti Ngurah Putu,Manuel Maestre-Reyna,Ming-Daw Tsai,Junpei Yamamoto,Maria Mittag,Lars-Oliver Essen, Nucleic Acids Research, Vol. 46, No. 15, p. 8010-8022, 2018/09
  • Fluorescence detection of DNA mismatch repair in human cells, Shunsuke Ito,Miyako Shiraishi,Kazuki Tsuchihashi,Reine Takatsuka,Junpei Yamamoto,Isao Kuraoka,Shigenori Iwai, Scientific Reports, Vol. 8, 2018/08
  • Coulomb and CH–π interactions in (6–4) photolyase–DNA complex dominate DNA binding and repair abilities, Yuma Terai,Ryuma Sato,Takahiro Yumiba,Ryuhei Harada,Kohei Shimizu,Tatsuya Toga,Tomoko Ishikawa-Fujiwara,Takeshi Todo,Shigenori Iwai,Yasuteru Shigeta,Junpei Yamamoto, Nucleic Acids Research, OXFORD UNIV PRESS, Vol. 46, No. 13, p. 6761-6772, 2018/07
  • Loss of Fourth Electron-Transferring Tryptophan in Animal (6-4) Photolyase Impairs DNA Repair Activity in Bacterial Cells, Junpei Yamamoto,Kohei Shimizu,Takahiro Kanda,Yuhei Hosokawa,Shigenori Iwai,Pascal Plaza,Pavel Mueller, BIOCHEMISTRY, AMER CHEMICAL SOC, Vol. 56, No. 40, p. 5356-5364, 2017/10
  • Ultrafast flavin photoreduction in an oxidized animal (6-4) photolyase through an unconventional tryptophan tetrad, Ryan Martin,Fabien Lacombat,Agathe Espagne,Nadia Dozova,Pascal Plaza,Junpei Yamamoto,Pavel Mueller,Klaus Brettel,Aurelien de la Lande, PHYSICAL CHEMISTRY CHEMICAL PHYSICS, ROYAL SOC CHEMISTRY, Vol. 19, No. 36, p. 24493-24504, 2017/09
  • The dominant role of proofreading exonuclease activity of replicative polymerase epsilon in cellular tolerance to cytarabine (Ara-C), Masataka Tsuda,Kazuhiro Terada,Masato Ooka,Koji Kobayashi,Hiroyuki Sasanuma,Ryo Fujisawa,Toshiki Tsurimoto,Junpei Yamamoto,Shigenori Iwai,Kei Kadoda,Remi Akagawa,Shar-Yin Naomi Huang,Yves Pommier,Julian E. Sale,Shunichi Takeda,Kouji Hirota, ONCOTARGET, IMPACT JOURNALS LLC, Vol. 8, No. 20, p. 33457-33474, 2017/05
  • Post-synthetic Modification of 3 ' Terminus of RNA with Propargylamine: A Versatile Scaffold for RNA Labeling through Copper-catalyzed Azide-Alkyne Cycloaddition, Junpei Yamamoto,Shohei Ebisuda,Lingqi Kong,Haruka Yamago,Shigenori Iwai, CHEMISTRY LETTERS, CHEMICAL SOC JAPAN, Vol. 46, No. 5, p. 767-770, 2017/05
  • Functional Conversion of CPD and (6-4) Photolyases by Mutation, Daichi Yamada,Hisham M. Dokainish,Tatsuya Iwata,Junpei Yamamoto,Tomoko Ishikawa,Takeshi Todo,Shigenori Iwai,Elizabeth D. Getzoff,Akio Kitao,Hideki Kandori, BIOCHEMISTRY, AMER CHEMICAL SOC, Vol. 55, No. 30, p. 4173-4183, 2016/08
  • Chemical Incorporation of Chain-Terminating Nucleoside Analogs as 3 '-Blocking DNA Damage and Their Removal by Human ERCC1-XPF Endonuclease, Junpei Yamamoto,Chiaki Takahata,Isao Kuraoka,Kouji Hirota,Shigenori Iwai, MOLECULES, MDPI AG, Vol. 21, No. 6, 2016/06
  • Structural Changes of the Active Center during the Photoactivation of Xenopus (6-4) Photolyase, Daichi Yamada,Junpei Yamamoto,Yu Zhang,Tatsuya Iwata,Kenichi Hitomi,Elizabeth D. Getzoff,Shigenori Iwai,Hideki Kandori, BIOCHEMISTRY, AMER CHEMICAL SOC, Vol. 55, No. 4, p. 715-723, 2016/02
  • Repriming by PrimPol is critical for DNA replication restart downstream of lesions and chain-terminating nucleosides, Kaori Kobayashi,Thomas A. Guilliam,Masataka Tsuda,Junpei Yamamoto,Laura J. Bailey,Shigenori Iwai,Shunichi Takeda,Aidan J. Doherty,Kouji Hirota, CELL CYCLE, TAYLOR & FRANCIS INC, Vol. 15, No. 15, p. 1997-2008, 2016
  • Structural role of two histidines in the (6-4) photolyase reaction, Daichi Yamada,Tatsuya Iwata,Junpei Yamamoto,Kenichi Hitomi,Takeshi Todo,Shigenori Iwai,Elizabeth D. Getzoff,Hideki Kandori, Biophysics and Physicobiology, Vol. 12, p. 139-144, 2015/12
  • Structural basis of pyrimidine-pyrimidone (6-4) photoproduct recognition by UV-DDB in the nucleosome., Akihisa Osakabe,Hiroaki Tachiwana,Wataru Kagawa,Naoki Horikoshi,Syota Matsumoto,Mayu Hasegawa,Naoyuki Matsumoto,Tatsuya Toga,Junpei Yamamoto,Fumio Hanaoka,Nicolas H Thomä,Kaoru Sugasawa,Shigenori Iwai,Hitoshi Kurumizaka, Scientific reports, Vol. 5, p. 16330-16330, 2015/11/17
  • Abacavir, an anti-HIV-1 drug, targets TDP1-deficient adult T cell leukemia, Kohei Tada,Masayuki Kobayashi,Yoko Takiuchi,Fumie Iwai,Takashi Sakamoto,Kayoko Nagata,Masanobu Shinohara,Katsuhiro Io,Kotaro Shirakawa,Masakatsu Hishizawa,Keisuke Shindo,Norimitsu Kadowaki,Kouji Hirota,Junpei Yamamoto,Shigenori Iwai,Hiroyuki Sasanuma,Shunichi Takeda,Akifumi Takaori-Kondo, SCIENCE ADVANCES, AMER ASSOC ADVANCEMENT SCIENCE, Vol. 1, No. 3, 2015/04
  • Analysis of Structural Flexibility of Damaged DNA Using Thiol-Tethered Oligonucleotide Duplexes, Masashi Fujita,Shun Watanabe,Mariko Yoshizawa,Junpei Yamamoto,Shigenori Iwai, PLOS ONE, PUBLIC LIBRARY SCIENCE, Vol. 10, No. 2, 2015/02
  • Ftir study of CPD photolyase with substrate in single strand DNA, I. M. Mahaputra Wijaya,Tatsuya Iwata,Junpei Yamamoto,Kenichi Hitomi,Shigenori Iwai,Elizabeth D. Getzoff,Hideki Kandori, Biophysics (Japan), Biophysical Society of Japan, Vol. 11, p. 39-45, 2015
  • Analysis of ATP and AMP binding to a DNA aptamer and its imidazole-tethered derivatives by surface plasmon resonance, Jing Zhao,Satoshi Katsube,Junpei Yamamoto,Kazuhiko Yamasaki,Makoto Miyagishi,Shigenori Iwai, ANALYST, ROYAL SOC CHEMISTRY, Vol. 140, No. 17, p. 5881-5884, 2015
  • Discovery and functional analysis of a 4th electron-transferring tryptophan conserved exclusively in animal cryptochromes and (6-4) photolyases, Pavel Mueller,Junpei Yamamoto,Ryan Martin,Shigenori Iwai,Klaus Brettel, CHEMICAL COMMUNICATIONS, ROYAL SOC CHEMISTRY, Vol. 51, No. 85, p. 15502-15505, 2015
  • Flavin Adenine Dinucleotide Chromophore Charge Controls the Conformation of Cyclobutane Pyrimidine Dimer Photolyase alpha-Helices, I. M. Mahaputra Wijaya,Tatsuya Iwata,Junpei Yamamoto,Kenichi Hitomi,Shigenori Iwai,Elizabeth D. Getzoff,John T. M. Kennis,Tilo Mathes,Hideki Kandori, BIOCHEMISTRY, AMER CHEMICAL SOC, Vol. 53, No. 37, p. 5864-5875, 2014/09
  • A cyclobutane thymine-N4-methylcytosine dimer is resistant to hydrolysis but strongly blocks DNA synthesis., Junpei Yamamoto,Tomoko Oyama,Tomohiro Kunishi,Chikahide Masutani,Fumio Hanaoka,Shigenori Iwai, Nucleic acids research, Vol. 42, No. 3, p. 2075-84, 2014/02
  • Deformable nature of various damaged DNA duplexes estimated by an electrochemical analysis on electrodes, J. Chiba,S. Aoki,J. Yamamoto,S. Iwai,M. Inouye, CHEMICAL COMMUNICATIONS, ROYAL SOC CHEMISTRY, Vol. 50, No. 76, p. 11126-11128, 2014
  • Repair of the (6-4) Photoproduct by DNA Photolyase Requires Two Photons, Junpei Yamamoto,Ryan Martin,Shigenori Iwai,Pascal Plaza,Klaus Brettel, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, WILEY-V C H VERLAG GMBH, Vol. 52, No. 29, p. 7432-7436, 2013/07
  • Detection of Distinct alpha-Helical Rearrangements of Cyclobutane Pyrimidine Dimer Photolyase upon Substrate Binding by Fourier Transform Infrared Spectroscopy, I. M. Mahaputra Wijaya,Yu Zhang,Tatsuya Iwata,Junpei Yamamoto,Kenichi Hitomi,Shigenori Iwai,Elizabeth D. Getzoff,Hideki Kandori, BIOCHEMISTRY, AMER CHEMICAL SOC, Vol. 52, No. 6, p. 1019-1027, 2013/02
  • Strand breakage of a (6-4) photoproduct-containing DNA at neutral pH and its repair by the ERCC1-XPF protein complex, Norihito Arichi,Junpei Yamamoto,Chiaki Takahata,Emi Sano,Yuji Masuda,Isao Kuraoka,Shigenori Iwai, ORGANIC & BIOMOLECULAR CHEMISTRY, ROYAL SOC CHEMISTRY, Vol. 11, No. 21, p. 3526-3534, 2013
  • Effects of 5 ',8-Cyclodeoxyadenosine Triphosphates on DNA Synthesis, Naoto Kamakura,Junpei Yamamoto,Philip J. Brooks,Shigenori Iwai,Isao Kuraoka, CHEMICAL RESEARCH IN TOXICOLOGY, AMER CHEMICAL SOC, Vol. 25, No. 12, p. 2718-2724, 2012/12
  • Eukaryotic Class II Cyclobutane Pyrimidine Dimer Photolyase Structure Reveals Basis for Improved Ultraviolet Tolerance in Plants, Kenichi Hitomi,Andrew S. Arvai,Junpei Yamamoto,Chiharu Hitomi,Mika Teranishi,Tokuhisa Hirouchi,Kazuo Yamamoto,Shigenori Iwai,John A. Tainer,Jun Hidema,Elizabeth D. Getzoff, JOURNAL OF BIOLOGICAL CHEMISTRY, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, Vol. 287, No. 15, p. 12060-12069, 2012/04
  • Mechanism of the alkali degradation of (6-4) photoproduct-containing DNA, Norihito Arichi,Aki Inase,Sachise Eto,Toshimi Mizukoshi,Junpei Yamamoto,Shigenori Iwai, ORGANIC & BIOMOLECULAR CHEMISTRY, ROYAL SOC CHEMISTRY, Vol. 10, No. 11, p. 2318-2325, 2012
  • Substrate Assignment of the (6-4) Photolyase Reaction by FTIR Spectroscopy, Yu Zhang,Junpei Yamamoto,Daichi Yamada,Tatsuya Iwata,Kenichi Hitomi,Takeshi Todo,Elizabeth D. Getzoff,Shigenori Iwai,Hideki Kandorit, JOURNAL OF PHYSICAL CHEMISTRY LETTERS, AMER CHEMICAL SOC, Vol. 2, No. 21, p. 2774-2777, 2011/11
  • FTIR Study of Light-Dependent Activation and DNA Repair Processes of (6-4) Photolyase, Yu Zhang,Tatsuya Iwata,Junpei Yamamoto,Kenichi Hitomi,Shigenori Iwai,Takeshi Todo,Elizabeth D. Getzoff,Hideki Kandori, BIOCHEMISTRY, AMER CHEMICAL SOC, Vol. 50, No. 18, p. 3591-3598, 2011/05
  • Light-Induced Conformational Change and Product Release in DNA Repair by (6-4) Photolyase, Masato Kondoh,Kenichi Hitomi,Junpei Yamamoto,Takeshi Todo,Shigenori Iwai,Elizabeth D. Getzoff,Masahide Terazima, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMER CHEMICAL SOC, Vol. 133, No. 7, p. 2183-2191, 2011/02
  • Photosensitized [2 + 2] cycloaddition of N-acetylated cytosine affords stereoselective formation of cyclobutane pyrimidine dimer., Junpei Yamamoto,Kosuke Nishiguchi,Koichiro Manabe,Chikahide Masutani,Fumio Hanaoka,Shigenori Iwai, Nucleic acids research, Vol. 39, No. 3, p. 1165-75, 2011/02
  • Human replicative DNA polymerase delta can bypass T-T (6-4) ultraviolet photoproducts on template strands, Takeo Narita,Toshiki Tsurimoto,Junpei Yamamoto,Kana Nishihara,Kaori Ogawa,Eiji Ohashi,Terry Evans,Shigenori Iwai,Shunichi Takeda,Kouji Hirota, GENES TO CELLS, WILEY-BLACKWELL, Vol. 15, No. 12, p. 1228-1239, 2010/12
  • Role of the carbonyl group of the (6-4) photoproduct in the (6-4) photolyase reaction, Junpei Yamamoto,Kenichi Hitomi,Ryosuke Hayashi,Elizabeth D. Getzoff,Shigenori Iwai, BIOCHEMISTRY, AMER CHEMICAL SOC, Vol. 48, No. 39, p. 9306-9312, 2009/10
  • Functional motifs in the (6-4) photolyase crystal structure make a comparative framework for DNA repair photolyases and clock cryptochromes, Kenichi Hitomi,Luciano DiTacchio,Andrew S. Arvai,Junpei Yamamoto,Sang-Tae Kim,Takeshi Todo,John A. Tainer,Shigenori Iwai,Satchidananda Panda,Elizabeth D. Getzoff, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, NATL ACAD SCIENCES, Vol. 106, No. 17, p. 6962-6967, 2009/04
  • Efficient conversion of thymine glycol into the formamide lesion in oligonucleotides, Tatsuya Toga,Junpei Yamamoto,Shigenori Iwai, TETRAHEDRON LETTERS, PERGAMON-ELSEVIER SCIENCE LTD, Vol. 50, No. 6, p. 723-726, 2009/02
  • Spectroscopic analysis of the pyrimidine(6-4)pyrimidone photoproduct: insights into the (6-4) photolyase reaction, Junpei Yamamoto,Yoshiyuki Tanaka,Shigenori Iwai, ORGANIC & BIOMOLECULAR CHEMISTRY, ROYAL SOC CHEMISTRY, Vol. 7, No. 1, p. 161-166, 2009
  • Chemical synthesis of oligodeoxyribonucleotides containing the Dewar valence isomer of the (6-4) photoproduct and their use in (6-4) photolyase studies, Junpei Yamamoto,Kenichi Hitomi,Takeshi Todo,Shigenori Iwai, NUCLEIC ACIDS RESEARCH, OXFORD UNIV PRESS, Vol. 34, No. 16, p. 4406-4415, 2006/09

Misc.

  • Dynamic control of sequential electron and proton transfer events in a flavoenzyme captured at SACLA, SPring-8/SACLA Information, Vol. 28, No. 2, p. 113-118, 2023/05
  • Theoretical Analyses for DNA Repair Function of Cryptochrome-DASH, 佐藤竜馬,森義治,松井理紗,沖本憲明,山元淳平,泰地真弘人, 生物物理(Web), Vol. 62, No. 2, 2022
  • (6–4)光回復酵素によるDNA認識および修復機構, 山元淳平, 日本核酸化学会誌, Vol. 2, p. 21-25, 2018/11
  • Repair of (6-4) Lesions in DNA by (6-4) Photolyase: 20 Years of Quest for the Photoreaction Mechanism, Junpei Yamamoto,Pascal Plaza,Klaus Brettel, PHOTOCHEMISTRY AND PHOTOBIOLOGY, WILEY, Vol. 93, No. 1, p. 51-66, 2017/01
  • A proposal for a novel DNA repair mechanism by the (6-4) photolyase, Junpei Yamamoto, Radiation Biology Research Communications, Vol. 50, No. 2, p. 174-184, 2015/05
  • (6-4)光回復酵素による 2光子DNA修復の分子メカニズム, 山元淳平, 生物物理, Vol. 55, No. 3, p. 157-158, 2015/05

Awards

  • The 10th young researcher award, Junpei Yamamoto, The Biophysical Society of Japan, 2014/09
  • Outstanding Oral Presentation Award, Junpei Yamamoto, The 39th International Symposium on Nucleic Acids Chemistry, 2012/11
  • Best Poster Award (Nucleic Acids Research Award), Junpei Yamamoto, The 6th International Symposium on Nucleic Acids Chemistry, 2009/09

Presentations

  • 時分割シリアルフェムト秒X線結晶構造解析によるDNA光回復酵素の全修復過程の原子分解能観測, 山元淳平,Manuel Maestre-Reyna,別所義隆,Lars-Oliver Essen,Ming-Daw Tsai, 日本放射線影響学会第66回年次大会, 2023/11/08
  • 時分割X線結晶構造解析で捉えたDNA光回復酵素によるDNA修復過程, 山元淳平,Manuel Maestre-Reyna,別所義隆,Lars-Oliver Essen,蔡明道, 第23回日本光生物学協会年会, 2023/08/30
  • 二元機能性動物類縁型クリプトクロムの 光活性化過程の動的構造解析, 山元淳平, 令和5年度新学術領域研究「高速分子動画」シンポジウム, 2023/05/10
  • 放射光レーザーを用いた生体分子時分割構造解析のイマとミライ, 山元淳平, 創発の場 -フォトニクス討論会- in 徳島, 2022/09/02
  • (6-4)光回復酵素による逐次2光子DNA修復反応の時間領域の決定, 山元淳平,Klaus Brettel,Pavel MÜLLER, 第48回生体分子科学討論会, 2022/07/01
  • (6-4)光回復酵素によるDNA修復過程の捕捉に向けて, 山元淳平, 令和三年度 新学術領域研究「高速分子動画」シンポジウム, 2021/11/01
  • ゲノム恒常性維持における量子性:青色光受容タンパク質による逐次2光子DNA修復, 山元淳平, 量子生命科学会 第２回大会, 2020/12/24
  • 人工集光アンテナ分子修飾による光回復酵素のDNA修復能の向上, 寺井悠馬,川上由夏,佐藤竜馬,岩井成憲,山元淳平, 第14回バイオ関連化学シンポジウム, 2020/09/07
  • 集光クマリン色素を有するDNA光回復酵素による高効率光駆動DNA修復, Yuma Terai,Ryuma Sato,Risa Matsumura,Shigenori Iwai,Junpei Yamamoto, 第57回日本生物物理学会年会, 2019/09/24
  • Facile post-synthetic functionalization of 3' terminus of DNA with alkyne and thiol, Junpei Yamamoto,Tatsuya Yajima,Shigenori Iwai, Commemorative International Symposium of the Japan Society of Nucleic Acids Chemistry 2019, 2019/07/23
  • (6-4)光回復酵素のDNA分子認識・修復機構, 山元淳平, 日本放射線影響学会 第６１回大会, 2018/11/08
  • DNA binding and light-dependent DNA repair abilities of photolyases, Junpei Yamamoto, 第56回日本生物物理学会年会, 2018/09/17
  • Coulomb and CH–π interactions in DNA-photolyase complex dominate DNA binding and repair abilities, Yuma Terai,Ryuma Sato,Takahiro Yumiba,Ryuhei Harada,Shigenori Iwai,Yasuteru Shigeta,Junpei Yamamoto, 第12回バイオ関連化学シンポジウム, 2018/09/09
  • Post synthetic modification of 3'-terminus of DNA for universal labeling, Junpei Yamamoto,Tatsuya Yajima,Shigenori Iwai, The 44th International Symposium on Nucleic Acids Chemistry, 2017/11/14
  • An arginine side chain in the (6-4) photolyase governs formation of a robust repair-active complex with UV-damaged DNA, Junpei Yamamoto,Yuma Terai,Ryuma Sato,Ryuhei Harada,Yasuteru Shigeta,Shigenori Iwai, 第55回日本生物物理学会年会, 2017/09/19
  • Monitoring of the back electron transfer in the successive two-photon DNA repair by the (6-4) photolyase, Junpei Yamamoto,Kohei Shimizu,Shigenori Iwai,Klaus Brettel, 第54回日本生物物理学会年会, 2016/11/26
  • Post-synthetic conjugation of propargylamine at the 3' terminus of RNA: a versatile scaffold for RNA modification by copper-catalyzed alkyne-azide cycloaddition, Junpei Yamamoto,Shohei Ebisuda,Shigenori Iwai, The 43rd International Symposium on Nucleic Acids Chemistry, 2016/09/27
  • Molecular mechanism of the successive two-photon DNA repair by the (6-4) photolyase, Junpei Yamamoto,Kohei Shimizu,Klaus Brettel,Shigenori Iwai, 2016/03/24
  • Human ERCC1-XPF endonuclease removes chain-terminating nucleoside analogs in DNA, Junpei Yamamoto,Chiaki Takahata,Isao Kuraoka,Kouji Hirota,Shigenori Iwai, BMB2015, 2015/12/01
  • Removal of chain-terminating nucleoside analogues in DNA by human ERCC1-XPF endonuclease, Junpei Yamamoto,Chiaki Takahata,Isao Kuraoka,Kouji Hirota,Shigenori Iwai, The 42nd International Symposium on Nucleic Acid Chemistry, 2015/09/26
  • An expanded electron transfer pathway in the (6-4) photolyase, Junpei Yamamoto,Pavel Muller,Kohei Shimizu,Klaus Brettel,Shigenori Iwai, 第53回日本生物物理学会年会, 2015/09/13
  • Synthesis of oligonucleotides containing chain-terminating antiviral drugs and their use in biochemical analyses, Junpei Yamamoto,Shigenori Iwai, The 41th International Symposium on Nucleic Acids Chemistry, 2014/11/06
  • Molecular mechanism of the two photon DNA repair by the (6-4) photolyas, Junpei Yamamoto,Kohei Shimizu,Tomoko Fujiwara,Takeshi Todo,Pascal Plaza,Klaus Brettel,Shigenori Iwai, 2014/09/25
  • 抗ウイルス剤を末端に有するオリゴヌクレオチドの合成とそれを用いた生化学解析, 山元淳平,岩井成憲, 第8回バイオ関連化学シンポジウム, 2014/09/11
  • 紫外線損傷DNAの化学合成及びその修復反応・変異機構解析, 山元淳平, 変異機構研究会第27回夏の学校, 2014/06/21
  • Biochemical and thermodynamic properties of a cyclobutane thymine-N4-methylcytosine dimer, Junpei Yamamoto,Tomoko Oyama,Tomohiro Kunishi,Shigenori Iwai, The 40th International Symposium on Nucleic Acids Chemistry, 2013/11/13
  • A two photon DNA repair mechanism of the (6-4) photolyase, Junpei Yamamoto,Ryan Martin,Shigenori Iwai,Pascal Plaza,Klaus Brettel, 2013/10/28
  • シトシン塩基由来シクロブタン型紫外線損傷DNAの安定アナログの合成とその性質, 山元淳平,小山智子,國司知宏,岩井成憲, 日本化学会第93春季年会, 2013/03/24
  • 紫外線損傷DNAにおける光回復酵素系の役割, 山元淳平, 太陽紫外線防御研究委員会第23回シンポジウム, 2013/03/15
  • Recognition and repair of the (6-4) photoproduct by DNA photolyase, Junpei Yamamoto,Ryan Martin,Shigenori Iwai,Pascal Plaza,Klaus Brettel, The 39th International Symposium on Nucleic Acids Chemistry, 2012/11/15
  • (6-4)光回復酵素による紫外線損傷DNA修復反応機構, 2012/09/06
  • (6-4)光回復酵素による紫外線損傷DNA修復反応機構, 山元淳平,Ryan Martin,岩井成憲,Pascal Plaza,Klaus Brettel, 第17回光生物学協会年会, 2012/08/18
  • 化学合成基質アナログの構造活性相関解析による(6-4)光回復酵素の基質認識・修復反応機構解析, 山元淳平,藤堂剛,岩井成憲, 第16回光生物学協会年会, 2010/08/10
  • DNA化学合成のためのシクロブタン型紫外線損傷の立体選択的形成, 山元淳平,西口浩佑,岩井成憲, 日本化学会第90春季年会, 2010/03/28
  • Recognition and reaction mechanism of the (6-4) photolyase as determined by using a (6-4) photoproduct analog, Junpei Yamamoto,Kenichi Hitomi,Ryosuke Hayashi,Elizabeth D. Getzoff,Shigenori Iwai, The 6th International Symposium on Nucleic Acids Chemistry, 2009/09/28
  • Translesion synthesis across the (6-4) photoproduct and its Dewar valence isomer by the Y-family and engineered DNA polymerases, Junpei Yamamoto,David Roakes,Chikahide Masutani,Shizu Simmyo,Kumiko Urabe,Fumio Hanaoka,Philipp Holliger,Shigenori Iwai, Joint Symposium of the 18th International Roundtable on Nucleosides, Nucleotides, and Nucleic Acids and the 35th International Symposium on Nucleic Acids Chemistry, 2008/09/09
  • Spectroscopic studies on a novel intramolecular hydrogen bond within the (6-4) photoproduct, Junpei Yamamoto,Yoshiyuki Tanaka,Kenichi Hitomi,Elizabeth D. Getzoff,Shigenori Iwai, The 5th International Symposium on Nucleic Acids Chemistry, 2007/11/20
  • A novel photodamage recognition mechanisms for eukaryotic CPD photolyase, Junpei Yamamoto,Kenichi Hitomi,Andrew S. Arvai,John A. Tainer,Kazuo Yamamoto,Mika Teranishi,Jun Hidema,Tadashi Kumagai,Tomoko Ishikawa,Takeshi Todo,Elizabeth D. Getzoff,Shigenori Iwai, The 4th International 3R (DNA Replication, Recombination, and Repair) Symposium, 2005/11/16

Media Coverage

  • ぶらっとラボ「光で治せ、紫外線由来の病気」, 2020/10/26

Social Activities

  • 構造生物学のフロンティアーDNA修復反応の直接検出に向けてー, 大阪大学基礎工学部, 第43回公開講座, 2022/08/03 - 2022/08/05
  • 大阪府立天王寺高等学校SSH研究指導, 2012/10 - 2013/03
  • 化学スーパーレッスン, 大阪府立天王寺高等学校, 2013/02/06 - 2013/02/06
  • サイエンスカフェ＠待兼山, 2009/10/31 - 2009/10/31
  • 構造生物学のフロンティア, 大阪大学SEEDSプログラム, 2022年体感科学技術, 2022/08/06 -
  • SSセミナー「化学の言葉で紡ぐ生命現象への誘い」, 高槻高校, 2020/10/02 -

Committee Memberships

  • 日本化学会近畿支部, 幹事, 2018/03 - 2020/02