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Koseki Masahiro

小関 正博

Graduate School of Medicine Division of Medicine, Assistant Professor

keyword Diabetic Cardiomyopathy,Apolipoprotein deficiency,Tangier disease,lipid metabolism,non-alcoholic steatohepatitis,7-ketocholesterol,nucleic acid medicine,high density lipoprotein,intestinal absorption,familial hypercholesterolemia,atherosclerosis,oxysterol

Education

  • - 2007/03, Osaka University, Graduate School, Division of Medical Sciences
  • - 1996/03, Ehime University, Faculty of Medicine, 医学科

Research History

  • 2018/10 - Present, Osaka University Graduate School of Medicine, Cardiovascular Medicine, assistant professor
  • 2018/01 - Present, Osaka University Graduate School of Medicine, Cardiovascular Medicine, assistant professor
  • 2017/04 - 2017/12, Osaka University Graduate School of Medicine, Health Care Division, Health and Counseling Center, assistant professor
  • 2015/04 - 2017/03, Osaka University Graduate School of Medicine, Health Care Center, assistant professor
  • 2013/04 - 2015/03, Osaka University Graduate School of Medicine, Cardiovascular Medicine, 特任研究員
  • 2008/07 - 2013/03, Columbia University Medical Center, Molecular Medicine, post doctral fellow
  • 2007/04 - 2008/06, Osaka University Graduate School of Medicine, Cardiovascular Medicine, 特任研究員
  • 2001/06 - 2002/03, Osaka University Hospital, Cardiovascular Medicine
  • 1999/06 - 2001/05, りんくう総合医療センター市立泉佐野病院, Cardiovascular Medicine
  • 1997/06 - 1999/05, りんくう総合医療センター市立泉佐野病院, Internal Medicine
  • 1996/06 - 1997/05, Osaka University Hospital, Internal Medicine

Research Areas

  • Life sciences, Cardiology, Cardiomyopathy
  • Life sciences, Gastroenterology, nonalcoholic fatty liver disease
  • Life sciences, Food sciences, Cholesterol
  • Life sciences, Metabolism and endocrinology
  • Life sciences, Cardiology, Atherosclerosis

Professional Memberships

  • 日本肝臓学会
  • 日本臨床栄養協会
  • 日本脂質生化学会
  • Japanese Association of Cardiovascular Intervention and Therapeutics
  • American Heart Association
  • 日本核酸医薬学会
  • 日本再生医療学会
  • 日本動脈硬化学会
  • 日本循環器学会
  • 日本内科学会

Papers

  • Dietary Oxysterol, 7-Ketocholesterol, Accelerates Hepatic Lipid Accumulation and Macrophage Infiltration in Obese Mice, Jiuyang Chang,Masahiro Koseki,Ayami Saga,Kotaro Kanno,Tomoaki Higo,Daisuke Okuzaki,Takeshi Okada,Hiroyasu Inui,Katsunao Tanaka,Masumi Asaji,Yinghong Zhu,Yoshihiro Kamada,Masafumi Ono,Toshiji Saibara,Ikuyo Ichi,Tohru Ohama,Makoto Nishida,Shizuya Yamashita,Yasushi Sakata, Frontier in Endocrinology, 2021/03/10
  • FIB-4 First in the Diagnostic Algorithm of Metabolic-Dysfunction- Associated Fatty Liver Disease in the Era of the Global Metabodemic, Yoshio Sumida,Masashi Yoneda,Katsutoshi Tokushige,Miwa Kawanaka,Hideki Fujii,Masato Yoneda,Kento Imajo,Hirokazu Takahashi,Yuichiro Eguchi,Masafumi Ono,Yuichi Nozaki,Hideyuki Hyogo,Masahiro Koseki,Yuichi Yoshida,Takumi Kawaguchi,Yoshihiro Kamada,Takeshi Okanoue,Atsushi Nakajima,Japan Study,Group of NAFLD,JSG-NAFLD, Life, Vol. 11, No. 2, 2021/02/14
  • Marked effects of novel selective peroxisome proliferator-activated receptor α modulator, pemafibrate in severe hypertriglyceridemia: preliminary report., Chie Iitake,Daisaku Masuda,Masahiro Koseki,Shizuya Yamashita, Cardiovascular Diabetology, Vol. 19, No. 1, p. 201-201, 2020/11/27
  • Development and Clinical Application of an Enzyme-Linked Immunosorbent Assay for Oxidized High-Density Lipoprotein., Takeshi Okada,Mizuki Sumida,Tohru Ohama,Yuki Katayama,Ayami Saga,Hiroyasu Inui,Kotaro Kanno,Daisaku Masuda,Masahiro Koseki,Makoto Nishida,Yasushi Sakata,Shizuya Yamashita, J Atheroscler Thromb., 2020/10/06
  • Progesterone receptor membrane associated component 1 enhances obesity progression in mice by facilitating lipid accumulation in adipocytes., Ryogo Furuhata,Yasuaki Kabe,Ayaka Kanai,Yuki Sugiura,Hitoshi Tsugawa,Eiji Sugiyama,Miwa Hirai,Takehiro Yamamoto,Ikko Koike,Noritada Yoshikawa,Hirotoshi Tanaka,Masahiro Koseki,Jun Nakae,Morio Matsumoto,Masaya Nakamura,Makoto Suematsu, Communications Biology, Vol. 3, No. 1, 2020/09/04
  • Loss of core fucosylation reduces low-density lipoprotein receptor expression in hepatocytes by inducing PCSK9 production., Yoshihiro Kamada,Akiko Yamamoto,Anna Fujiyoshi,Masahiro Koseki,Koichi Morishita,Tatsuya Asuka,Shinji Takamatsu,Yasushi Sakata,Tetsuo Takehara,Naoyuki Taniguchi,Eiji Miyoshi, Biochem Biophys Res Commun., Vol. 527, No. 3, p. 682-688, 2020/06/30
  • Serum Mac-2 Binding Protein Levels Associate with Metabolic Parameters and Predict Liver Fibrosis Progression in Subjects with Fatty Liver Disease: A 7-Year Longitudinal Study., Yoshihiro Kamada,Koichi Morishita,Masahiro Koseki,Mayu Nishida,Tatsuya Asuka,Yukiko Naito,Makoto Yamada,Shinji Takamatsu,Yasushi Sakata,Tetsuo Takehara,Eiji Miyoshi, Nutrients, Vol. 12, No. 6, 2020/06/12
  • Antidiabetic Therapy in the Treatment of Nonalcoholic Steatohepatitis., Yoshio Sumida,Masashi Yoneda,Katsutoshi Tokushige,Miwa Kawanaka,Hideki Fujii,Masato Yoneda,Kento Imajo,Hirokazu Takahashi,Yuichiro Eguchi,Masafumi Ono,Yuichi Nozaki,Hideyuki Hyogo,Masahiro Koseki,Yuichi Yoshida,Takumi Kawaguchi,Yoshihiro Kamada,Takeshi Okanoue,Atsushi Nakajima,Japan Study Group Of Nafld Jsg-Nafld, Int J Mol Sci., Vol. 21, No. 6, 2020/03/11
  • Reducing the Clinical and Public Health Burden of Familial Hypercholesterolemia: A Global Call to Action., Katherine A Wilemon,Jasmine Patel,Carlos Aguilar-Salinas,Catherine D Ahmed,Mutaz Alkhnifsawi,Wael Almahmeed,Rodrigo Alonso,Khalid Al-Rasadi,Lina Badimon,Luz M Bernal,Martin P Bogsrud,Lynne T Braun,Liam Brunham,Alberico L Catapano,Kristyna Cillíková,Pablo Corral,Regina Cuevas,Joep C Defesche,Olivier S Descamps,Sarah de Ferranti,Jean-Luc Eiselé,Gerardo Elikir,Emanuela Folco,Tomas Freiberger,Francesco Fuggetta,Isabel M Gaspar,Ákos G Gesztes,Urh Grošelj,Ian Hamilton-Craig,Gabriele Hanauer-Mader,Mariko Harada-Shiba,Gloria Hastings,G Kees Hovingh,Maria C Izar,Allison Jamison,Gunnar N Karlsson,Meral Kayikçioglu,Sue Koob,Masahiro Koseki,Stacey Lane,Marcos M Lima-Martinez,Greizy López,Tania L Martinez,David Marais,Letrillart Marion,Pedro Mata,Inese Maurina,Diana Maxwell,Roopa Mehta,George A Mensah,André R Miserez,Dermot Neely,Stephen J Nicholls,Atsushi Nohara,Børge G Nordestgaard,Leiv Ose,Athanasios Pallidis,Jing Pang,Jules Payne,Amy L Peterson,Monica P Popescu,Raman Puri,Kausik K Ray,Ashraf Reda,Tiziana Sampietro,Raul D Santos,Inge Schalkers,Laura Schreier,Michael D Shapiro,Eric Sijbrands,Daniel Soffer,Claudia Stefanutti,Mario Stoll,Rody G Sy,Martha L Tamayo,Myra K Tilney,Lale Tokgözoglu,Brian Tomlinson,Antonio J Vallejo-Vaz,Alejandra Vazquez-Cárdenas,Patrícia Vieira de Luca,David S Wald,Gerald F Watts,Nanette K Wenger,Michaela Wolf,David Wood,Aram Zegerius,Thomas A Gaziano,Samuel S Gidding, JAMA Cardiology, Vol. 5, No. 2, p. 217-229, 2020/02/01
  • Progranulin deficiency leads to enhanced age-related cardiac hypertrophy through complement C1q-induced β-catenin activation., Zhu Y,Ohama T,Kawase R,Chang J,Inui H,Kanno K,Okada T,Masuda D,Koseki M,Nishida M,Sakata Y,Yamashita S, Journal of Molecular and Cellular Cardiology, Vol. 138, p. 197-211, 2020/01
  • Rivaroxaban Suppresses the Progression of Ischemic Cardiomyopathy in a Murine Model of Diet-Induced Myocardial Infarction., Liu J,Nishida M,Inui H,Chang J,Zhu Y,Kanno K,Matsuda H,Sairyo M,Okada T,Nakaoka H,Ohama T,Masuda D,Koseki M,Yamashita S,Sakata Y, Journal of Atherosclerosis and Thrombosis, Vol. 26, No. 10, p. 915-930, 2019/10
  • Shotgun proteomic analysis reveals proteome alterations in HDL of patients with cholesteryl ester transfer protein deficiency., Okada T,Ohama T,Takafuji K,Kanno K,Matsuda H,Sairyo M,Zhu Y,Saga A,Kobayashi T,Masuda D,Koseki M,Nishida M,Sakata Y,Yamashita S, Journal of clinical lipidology, Vol. 13, No. 2, p. 317-325, 2019/03
  • Pressure Overload Impairs Cardiac Function in Long-Chain Fatty Acid Transporter CD36-Knockout Mice., Nakatani K,Masuda D,Kobayashi T,Sairyo M,Zhu Y,Okada T,Naito AT,Ohama T,Koseki M,Oka T,Akazawa H,Nishida M,Komuro I,Sakata Y,Yamashita S, Int Heart J., Vol. 60, No. 1, p. 159-167, 2019/01
  • 【ビヨンドコレステロール時代の動脈硬化リスク管理】小腸におけるコレステロール吸収と動脈硬化, Vol. 36, No. 10, p. 57-60, 2018/10
  • Accelerated Atherogenicity in Tangier Disease., Vol. 25, No. 10, p. 1076-1085, 2018/10
  • Accelerated Atherogenicity in Tangier Disease., Muratsu J,Koseki M,Masuda D,Yasuga Y,Tomoyama S,Ataka K,Yagi Y,Nakagawa A,Hamada H,Fujita S,Hattori H,Ohama T,Nishida M,Hiraoka H,Matsuzawa Y,Yamashita S, J Atheroscler Thromb., Vol. 25, No. 10, p. 1076-1085, 2018/10
  • Statement for Appropriate Clinical Use of PCSK9 Inhibitors, 2018/08
  • Statement for Appropriate Clinical Use of PCSK9 Inhibitors, Vol. 25, No. 8, p. 747-750, 2018/08
  • Statement for Appropriate Clinical Use of PCSK9 Inhibitors., Nohara A,Ohmura H,Okazaki H,Ogura M,Kitagawa K,Koseki M,Sato K,Tsukamoto K,Yamashita S,Japan Atherosclerosis Society Working,Group on Statement for Appropriate Use of PCSK,Inhibitors, Journal of atherosclerosis and thrombosis, Vol. 25, No. 8, p. 747-750, 2018/08
  • 【脂質代謝異常と循環器疾患】識る オキシステロールと動脈硬化, Vol. 22, No. 7, p. 673-678, 2018/07
  • 冠動脈硬化と頸動脈分岐部狭窄を来した弾性繊維性仮性黄色腫の1例, 冠野 昂太郎,小関 正博,乾 洋勉,松田 響,西良 雅己,岡田 健志,増田 大作,大濱 透,西田 誠,室田 浩之,山下 静也,大阪大学医学部医学系研究科循環器内科学脂質,動脈硬化研究グループ, 日本動脈硬化学会総会プログラム・抄録集, Vol. 50回, p. 328-328, 2018/06
  • NAFDL/NASH診療のイノベーション ~ガイドラインからパイプラインへ~ 「心血管・動脈硬化性疾患~肝が心血管を征服する?」, 2018/06
  • 【NAFLD/NASH診療のイノベーション-ガイドラインからパイプラインへ】全身疾患とNAFLD/NASH 心血管・動脈硬化性疾患 肝が心血管を征服する?, Vol. 121, No. 6, p. 1315-1317, 2018/06
  • Clinical features and visual function in a patient with Fish-eye disease: Quantitative measurements and optical coherence tomography, Masanori Kanai,Shizuka Koh,Daisaku Masuda,Masahiro Koseki,Kohji Nishida, American Journal of Ophthalmology Case Reports, Elsevier Inc, Vol. 10, p. 137-141, 2018/06/01
  • Pressure Overload Impairs Cardiac Function in Long-chain Fatty Acid Transporter CD36-Knockout Mice, 2018/06
  • Clinical features and visual function in a patient with Fish-eye disease: Quantitative measurements and optical coherence tomography, Masanori Kanai,Shizuka Koh,Daisaku Masuda,Masahiro Koseki,Kohji Nishida, American Journal of Ophthalmology Case Reports, Elsevier Inc, Vol. 10, p. 137-141, 2018/06/01
  • WEEKEND CATCH-UP SLEEP AND PREVALENCE OF PROTEINURIA: A CROSS-SECTIONAL STUDY, Aoki Katsunori,Yamamoto Ryohei,Shinzawa Maki,Kimura Yoshiki,Fujii Yoshiyuki,Nakanishi Kaori,Koseki Masahiro,Nishida Makoto,Takihara Keiko,Isaka Yoshitaka,Moriyama Toshiki, NEPHROLOGY DIALYSIS TRANSPLANTATION, Vol. 33, 2018/05
  • 【精神科診療でみられる検査値異常の鑑別とその対応】LDL-C、HDL-C、TG、Non-HDL-C、TC, Vol. 47, No. 4, p. 427-437, 2018/04
  • 脂質異常症のHot Topics-動脈硬化性疾患ガイドライン2017の改訂をふまえて-, 2018/03
  • A novel selective PPARαmodulator (SPPARMα), K-877 (pemafibrate), attenuates postprandial hypertriglyceridemia in mice, Masami Sairyo,Takuya Kobayashi,Daisaku Masuda,Koutaro Kanno,Yinghong Zhu,Takeshi Okada,Masahiro Koseki,Tohru Ohama,Makoto Nishida,Yasushi Sakata,Shizuya Yamashita, Journal of Atherosclerosis and Thrombosis, Japan Atherosclerosis Society, Vol. 25, No. 2, p. 142-152, 2018
  • コレステロールの基礎と臨床的意義, 2018/01
  • Effects of a dipeptidyl peptidase 4 inhibitor sitagliptin on glycemic control and lipoprotein metabolism in patients with type 2 diabetes mellitus (GLORIA trial), Daisaku Masuda,Takuya Kobayashi,Masami Sairyou,Hiroyuki Hanada,Tohru Ohama,Masahiro Koseki,Makoto Nishida,Norikazu Maeda,Shinji Kihara,Tatsuya Minami,Koji Yanagi,Yasushi Sakata,Shizuya Yamashita, Journal of Atherosclerosis and Thrombosis, Japan Atherosclerosis Society, Vol. 25, No. 6, p. 512-520, 2018
  • Particle number analysis of lipoprotein subclasses by gel permeation HPLC in patients with cholesteryl ester transfer protein deficiency, Takeshi Okada,Tohru Ohama,Mitsuyo Okazaki,Kotaro Kanno,Hibiki Matsuda,Masami Sairyo,Yinghong Zhu,Ayami Saga,Takuya Kobayashi,Daisaku Masuda,Masahiro Koseki,Makoto Nishida,Yasushi Sakata,Shizuya Yamashita, PLoS ONE, Public Library of Science, Vol. 13, No. 1, 2018/01/01
  • A novel selective PPARαmodulator (SPPARMα), K-877 (pemafibrate), attenuates postprandial hypertriglyceridemia in mice, Masami Sairyo,Takuya Kobayashi,Daisaku Masuda,Koutaro Kanno,Yinghong Zhu,Takeshi Okada,Masahiro Koseki,Tohru Ohama,Makoto Nishida,Yasushi Sakata,Shizuya Yamashita, Journal of Atherosclerosis and Thrombosis, Japan Atherosclerosis Society, Vol. 25, No. 2, p. 142-152, 2018
  • An implication of Klotho-related molecules in different smoking-related health outcomes between men and women, Kaori Nakanishi,Makoto Nishida,Ryohei Yamamoto,Masahiro Koseki,Toshiki Moriyama,Keiko Yamauchi-Takihara, Clinica Chimica Acta, Elsevier B.V., Vol. 476, p. 44-48, 2018/01/01
  • A novel selective PPARαmodulator (SPPARMα), K-877 (pemafibrate), attenuates postprandial hypertriglyceridemia in mice, Masami Sairyo,Takuya Kobayashi,Daisaku Masuda,Koutaro Kanno,Yinghong Zhu,Takeshi Okada,Masahiro Koseki,Tohru Ohama,Makoto Nishida,Yasushi Sakata,Shizuya Yamashita, Journal of Atherosclerosis and Thrombosis, Japan Atherosclerosis Society, Vol. 25, No. 2, p. 142-152, 2018
  • An implication of Klotho-related molecules in different smoking-related health outcomes between men and women, Kaori Nakanishi,Makoto Nishida,Ryohei Yamamoto,Masahiro Koseki,Toshiki Moriyama,Keiko Yamauchi-Takihara, Clinica Chimica Acta, Elsevier B.V., Vol. 476, p. 44-48, 2018/01/01
  • Effects of a dipeptidyl peptidase 4 inhibitor sitagliptin on glycemic control and lipoprotein metabolism in patients with type 2 diabetes mellitus (GLORIA trial), Daisaku Masuda,Takuya Kobayashi,Masami Sairyou,Hiroyuki Hanada,Tohru Ohama,Masahiro Koseki,Makoto Nishida,Norikazu Maeda,Shinji Kihara,Tatsuya Minami,Koji Yanagi,Yasushi Sakata,Shizuya Yamashita, Journal of Atherosclerosis and Thrombosis, Japan Atherosclerosis Society, Vol. 25, No. 6, p. 512-520, 2018
  • Particle number analysis of lipoprotein subclasses by gel permeation HPLC in patients with cholesteryl ester transfer protein deficiency, Takeshi Okada,Tohru Ohama,Mitsuyo Okazaki,Kotaro Kanno,Hibiki Matsuda,Masami Sairyo,Yinghong Zhu,Ayami Saga,Takuya Kobayashi,Daisaku Masuda,Masahiro Koseki,Makoto Nishida,Yasushi Sakata,Shizuya Yamashita, PLoS ONE, Public Library of Science, Vol. 13, No. 1, 2018/01/01
  • A novel selective PPARαmodulator (SPPARMα), K-877 (pemafibrate), attenuates postprandial hypertriglyceridemia in mice, Masami Sairyo,Takuya Kobayashi,Daisaku Masuda,Koutaro Kanno,Yinghong Zhu,Takeshi Okada,Masahiro Koseki,Tohru Ohama,Makoto Nishida,Yasushi Sakata,Shizuya Yamashita, Journal of Atherosclerosis and Thrombosis, Japan Atherosclerosis Society, Vol. 25, No. 2, p. 142-152, 2018
  • NIGHT SHIFT FREQUENCY AND INCIDENCE OF PROTEINURIA: A RETROSPECTIVE COHORT STUDY, Yamamto Ryohei,Shinzawa Maki,Kimura Yoshiki,Fujii Yoshiyuki,Aoki Katsunori,Nakanishi Kaori,Koseki Masahiro,Nishida Makoto,Nishida Makoto,Yamauchi-Takihara Keiko,Isaka Yoshitaka,Moriyama Toshiki, NEPHROLOGY DIALYSIS TRANSPLANTATION, Vol. 32, 2017/05
  • Molecular Mechanisms of Hyperalphalipoproteinemia, Shizuya Yamashita,Daisaku Masuda,Tohru Ohama,Masahiro Koseki, The HDL Handbook: Biological Functions and Clinical Implications: Third Edition, Elsevier Inc., p. 1-21, 2017/02/22
  • Association between N-terminal pro-brain natriuretic peptide and adiponectin in healthy Japanese men, Kaori Nakanishi,Makoto Nishida,Ryohei Yamamoto,Masahiro Koseki,Toshiki Moriyama,Keiko Yamauchi-Takihara, CLINICA CHIMICA ACTA, ELSEVIER SCIENCE BV, Vol. 460, p. 138-141, 2016/09
  • Association between N-terminal pro-brain natriuretic peptide and adiponectin in healthy Japanese men, Kaori Nakanishi,Makoto Nishida,Ryohei Yamamoto,Masahiro Koseki,Toshiki Moriyama,Keiko Yamauchi-Takihara, CLINICA CHIMICA ACTA, ELSEVIER SCIENCE BV, Vol. 460, p. 138-141, 2016/09
  • TTC39B deficiency stabilizes LXR reducing both atherosclerosis and steatohepatitis, Joanne Hsieh,Masahiro Koseki,Matthew M. Molusky,Emi Yakushiji,Ikuyo Ichi,Marit Westerterp,Jahangir Iqbal,Robin B. Chan,Sandra Abramowicz,Liana Tascau,Shunichi Takiguchi,Shizuya Yamashita,Carrie L. Welch,Gilbert Di Paolo,M. Mahmood Hussain,Jay H. Lefkowitch,Daniel J. Rader,Alan R. Tall, NATURE, NATURE PUBLISHING GROUP, Vol. 535, No. 7611, p. 303-U282, 2016/07
  • TTC39B deficiency stabilizes LXR reducing both atherosclerosis and steatohepatitis, Joanne Hsieh,Masahiro Koseki,Matthew M. Molusky,Emi Yakushiji,Ikuyo Ichi,Marit Westerterp,Jahangir Iqbal,Robin B. Chan,Sandra Abramowicz,Liana Tascau,Shunichi Takiguchi,Shizuya Yamashita,Carrie L. Welch,Gilbert Di Paolo,M. Mahmood Hussain,Jay H. Lefkowitch,Daniel J. Rader,Alan R. Tall, NATURE, NATURE PUBLISHING GROUP, Vol. 535, No. 7611, p. 303-U282, 2016/07
  • Myocardial energy provision is preserved by increased utilization of glucose and ketone bodies in CD36 knockout mice, Kazuhiro Nakatani,Tadashi Watabe,Daisaku Masuda,Masao Imaizumi,Eku Shimosegawa,Takuya Kobayashi,Masami Sairyo,Yinghong Zhu,Takeshi Okada,Ryota Kawase,Hajime Nakaoka,Atsuhiko Naito,Tohru Ohama,Masahiro Koseki,Toru Oka,Hiroshi Akazawa,Makoto Nishida,Issei Komuro,Yasushi Sakata,Jun Hatazawa,Shizuya Yamashita, METABOLISM-CLINICAL AND EXPERIMENTAL, W B SAUNDERS CO-ELSEVIER INC, Vol. 64, No. 9, p. 1165-1174, 2015/09
  • Myocardial energy provision is preserved by increased utilization of glucose and ketone bodies in CD36 knockout mice, Kazuhiro Nakatani,Tadashi Watabe,Daisaku Masuda,Masao Imaizumi,Eku Shimosegawa,Takuya Kobayashi,Masami Sairyo,Yinghong Zhu,Takeshi Okada,Ryota Kawase,Hajime Nakaoka,Atsuhiko Naito,Tohru Ohama,Masahiro Koseki,Toru Oka,Hiroshi Akazawa,Makoto Nishida,Issei Komuro,Yasushi Sakata,Jun Hatazawa,Shizuya Yamashita, METABOLISM-CLINICAL AND EXPERIMENTAL, W B SAUNDERS CO-ELSEVIER INC, Vol. 64, No. 9, p. 1165-1174, 2015/09
  • 脆弱な冠動脈プラークの安定化におけるprogranulinの役割(Roles of Progranulin in the stabilization of vulnerable coronary arterial plaques), Kawase Ryota,Ohama Tohru,Morita Masaya,Kurozumi Yuma,Ito Noritoshi,Okada Takeshi,Masuda Daisaku,Koseki Masahiro,Nishida Makoto,Sawano Makoto,Doi Yasuharu,Sakata Yasushi,Yamashita Shizuya, 日本動脈硬化学会総会プログラム・抄録集, (一社)日本動脈硬化学会, Vol. 47回, p. 222-222, 2015/06
  • 急性冠症候群におけるHDL関連抗炎症性蛋白であるprogranulinの役割(Roles of an HDL-associated Anti-inflammatory Protein, Progranulin, in Acute Coronary Syndrome), Kawase Ryota,Ohama Tohru,Morita Masaya,Kurozumi Yuma,Ito Noritoshi,Sairyo Masami,Zhu Yinghong,Okada Takeshi,Nakaoka Hajime,Nakatani Kazuhiro,Masuda Daisaku,Koseki Masahiro,Nishida Makoto,Sawano Hirotaka,Doi Yasuharu,Sakata Yasushi,Yamashita Shizuya, Circulation Journal, (一社)日本循環器学会, Vol. 79, No. Suppl.I, p. 2260-2260, 2015/03
  • Biological, clinical and population relevance of 95 loci for blood lipids, Tanya M. Teslovich,Kiran Musunuru,Albert V. Smith,Andrew C. Edmondson,Ioannis M. Stylianou,Masahiro Koseki,James P. Pirruccello,Samuli Ripatti,Daniel I. Chasman,Cristen J. Willer,Christopher T. Johansen,Sigrid W. Fouchier,Aaron Isaacs,Gina M. Peloso,Maja Barbalic,Sally L. Ricketts,Joshua C. Bis,Yurii S. Aulchenko,Gudmar Thorleifsson,Mary F. Feitosa,John Chambers,Marju Orho-Melander,Olle Melander,Toby Johnson,Xiaohui Li,Xiuqing Guo,Mingyao Li,Yoon Shin Cho,Min Jin Go,Young Jin Kim,Jong-Young Lee,Taesung Park,Kyunga Kim,Xueling Sim,Rick Twee-Hee Ong,Damien C. Croteau-Chonka,Leslie A. Lange,Joshua D. Smith,Kijoung Song,Jing Hua Zhao,Xin Yuan,Jian'an Luan,Claudia Lamina,Andreas Ziegler,Weihua Zhang,Robert Y. L. Zee,Alan F. Wright,Jacqueline C. M. Witteman,James F. Wilson,Gonneke Willemsen,H. -Erich Wichmann,John B. Whitfield,Dawn M. Waterworth,Nicholas J. Wareham,Gerard Waeber,Peter Vollenweider,Benjamin F. Voight,Veronique Vitart,Andre G. Uitterlinden,Manuela Uda,Jaakko Tuomilehto,John R. Thompson,Toshiko Tanaka,Ida Surakka,Heather M. Stringham,Tim D. Spector,Nicole Soranzo,Johannes H. Smit,Juha Sinisalo,Kaisa Silander,Eric J. G. Sijbrands,Angelo Scuteri,James Scott,David Schlessinger,Serena Sanna,Veikko Salomaa,Juha Saharinen,Chiara Sabatti,Aimo Ruokonen,Igor Rudan,Lynda M. Rose,Robert Roberts,Mark Rieder,Bruce M. Psaty,Peter P. Pramstaller,Irene Pichler,Markus Perola,Brenda W. J. H. Penninx,Nancy L. Pedersen,Cristian Pattaro,Alex N. Parker,Guillaume Pare,Ben A. Oostra,Christopher J. O'Donnell,Markku S. Nieminen,Deborah A. Nickerson,Grant W. Montgomery,Thomas Meitinger,Ruth McPherson,Mark I. McCarthy,Wendy McArdle,David Masson,Nicholas G. Martin,Fabio Marroni,Massimo Mangino,Patrik K. E. Magnusson,Gavin Lucas,Robert Luben,Ruth J. F. Loos,Marja-Liisa Lokki,Guillaume Lettre,Claudia Langenberg,Lenore J. Launer,Edward G. Lakatta,Reijo Laaksonen,Kirsten O. Kyvik,Florian Kronenberg,Inke R. Koenig,Kay-Tee Khaw,Jaakko Kaprio,Lee M. Kaplan,Asa Johansson,Marjo-Riitta Jarvelin,A. Cecile J. W. Janssens,Erik Ingelsson,Wilmar Igi,G. Kees Hovingh,Jouke-Jan Hottenga,Albert Hofman,Andrew A. Hicks,Christian Hengstenberg,Iris M. Heid,Caroline Hayward,Aki S. Havulinna,Nicholas D. Hastie,Tamara B. Harris,Talin Haritunians,Alistair S. Hall,Ulf Gyllensten,Candace Guiducci,Leif C. Groop,Elena Gonzalez,Christian Gieger,Nelson B. Freimer,Luigi Ferrucci,Jeanette Erdmann,Paul Elliott,Kenechi G. Ejebe,Angela Doering,Anna F. Dominiczak,Serkalem Demissie,Panagiotis Deloukas,Eco J. C. de Geus,Ulf de Faire,Gabriel Crawford,Francis S. Collins,Yii-der I. Chen,Mark J. Caulfield,Harry Campbell,Noel P. Burtt,Lori L. Bonnycastle,Dorret I. Boomsma,S. Matthijs Boekholdt,Richard N. Bergman,Ines Barroso,Stefania Bandinelli,Christie M. Ballantyne,Themistocles L. Assimes,Thomas Quertermous,David Altshuler,Mark Seielstad,Tien Y. Wong,E-Shyong Tai,Alan B. Feranil,Christopher W. Kuzawa,Linda S. Adair,Herman A. Taylor,Ingrid B. Borecki,Stacey B. Gabriel,James G. Wilson,Hilma Holm,Unnur Thorsteinsdottir,Vilmundur Gudnason,Ronald M. Krauss,Karen L. Mohlke,Jose M. Ordovas,Patricia B. Munroe,Jaspal S. Kooner,Alan R. Tall,Robert A. Hegele,John J. P. Kastelein,Eric E. Schadt,Jerome I. Rotter,Eric Boerwinkle,David P. Strachan,Vincent Mooser,Kari Stefansson,Muredach P. Reilly,Nilesh J. Samani,Heribert Schunkert,L. Adrienne Cupples,Manjinder S. Sandhu,Paul M. Ridker,Daniel J. Rader,Cornelia M. van Duijn,Leena Peltonen,Goncalo R. Abecasis,Michael Boehnke,Sekar Kathiresan, NATURE, NATURE PUBLISHING GROUP, Vol. 466, No. 7307, p. 707-713, 2010/08
  • Biological, clinical and population relevance of 95 loci for blood lipids, Tanya M. Teslovich,Kiran Musunuru,Albert V. Smith,Andrew C. Edmondson,Ioannis M. Stylianou,Masahiro Koseki,James P. Pirruccello,Samuli Ripatti,Daniel I. Chasman,Cristen J. Willer,Christopher T. Johansen,Sigrid W. Fouchier,Aaron Isaacs,Gina M. Peloso,Maja Barbalic,Sally L. Ricketts,Joshua C. Bis,Yurii S. Aulchenko,Gudmar Thorleifsson,Mary F. Feitosa,John Chambers,Marju Orho-Melander,Olle Melander,Toby Johnson,Xiaohui Li,Xiuqing Guo,Mingyao Li,Yoon Shin Cho,Min Jin Go,Young Jin Kim,Jong-Young Lee,Taesung Park,Kyunga Kim,Xueling Sim,Rick Twee-Hee Ong,Damien C. Croteau-Chonka,Leslie A. Lange,Joshua D. Smith,Kijoung Song,Jing Hua Zhao,Xin Yuan,Jian'an Luan,Claudia Lamina,Andreas Ziegler,Weihua Zhang,Robert Y. L. Zee,Alan F. Wright,Jacqueline C. M. Witteman,James F. Wilson,Gonneke Willemsen,H. -Erich Wichmann,John B. Whitfield,Dawn M. Waterworth,Nicholas J. Wareham,Gerard Waeber,Peter Vollenweider,Benjamin F. Voight,Veronique Vitart,Andre G. Uitterlinden,Manuela Uda,Jaakko Tuomilehto,John R. Thompson,Toshiko Tanaka,Ida Surakka,Heather M. Stringham,Tim D. Spector,Nicole Soranzo,Johannes H. Smit,Juha Sinisalo,Kaisa Silander,Eric J. G. Sijbrands,Angelo Scuteri,James Scott,David Schlessinger,Serena Sanna,Veikko Salomaa,Juha Saharinen,Chiara Sabatti,Aimo Ruokonen,Igor Rudan,Lynda M. Rose,Robert Roberts,Mark Rieder,Bruce M. Psaty,Peter P. Pramstaller,Irene Pichler,Markus Perola,Brenda W. J. H. Penninx,Nancy L. Pedersen,Cristian Pattaro,Alex N. Parker,Guillaume Pare,Ben A. Oostra,Christopher J. O'Donnell,Markku S. Nieminen,Deborah A. Nickerson,Grant W. Montgomery,Thomas Meitinger,Ruth McPherson,Mark I. McCarthy,Wendy McArdle,David Masson,Nicholas G. Martin,Fabio Marroni,Massimo Mangino,Patrik K. E. Magnusson,Gavin Lucas,Robert Luben,Ruth J. F. Loos,Marja-Liisa Lokki,Guillaume Lettre,Claudia Langenberg,Lenore J. Launer,Edward G. Lakatta,Reijo Laaksonen,Kirsten O. Kyvik,Florian Kronenberg,Inke R. Koenig,Kay-Tee Khaw,Jaakko Kaprio,Lee M. Kaplan,Asa Johansson,Marjo-Riitta Jarvelin,A. Cecile J. W. Janssens,Erik Ingelsson,Wilmar Igi,G. Kees Hovingh,Jouke-Jan Hottenga,Albert Hofman,Andrew A. Hicks,Christian Hengstenberg,Iris M. Heid,Caroline Hayward,Aki S. Havulinna,Nicholas D. Hastie,Tamara B. Harris,Talin Haritunians,Alistair S. Hall,Ulf Gyllensten,Candace Guiducci,Leif C. Groop,Elena Gonzalez,Christian Gieger,Nelson B. Freimer,Luigi Ferrucci,Jeanette Erdmann,Paul Elliott,Kenechi G. Ejebe,Angela Doering,Anna F. Dominiczak,Serkalem Demissie,Panagiotis Deloukas,Eco J. C. de Geus,Ulf de Faire,Gabriel Crawford,Francis S. Collins,Yii-der I. Chen,Mark J. Caulfield,Harry Campbell,Noel P. Burtt,Lori L. Bonnycastle,Dorret I. Boomsma,S. Matthijs Boekholdt,Richard N. Bergman,Ines Barroso,Stefania Bandinelli,Christie M. Ballantyne,Themistocles L. Assimes,Thomas Quertermous,David Altshuler,Mark Seielstad,Tien Y. Wong,E-Shyong Tai,Alan B. Feranil,Christopher W. Kuzawa,Linda S. Adair,Herman A. Taylor,Ingrid B. Borecki,Stacey B. Gabriel,James G. Wilson,Hilma Holm,Unnur Thorsteinsdottir,Vilmundur Gudnason,Ronald M. Krauss,Karen L. Mohlke,Jose M. Ordovas,Patricia B. Munroe,Jaspal S. Kooner,Alan R. Tall,Robert A. Hegele,John J. P. Kastelein,Eric E. Schadt,Jerome I. Rotter,Eric Boerwinkle,David P. Strachan,Vincent Mooser,Kari Stefansson,Muredach P. Reilly,Nilesh J. Samani,Heribert Schunkert,L. Adrienne Cupples,Manjinder S. Sandhu,Paul M. Ridker,Daniel J. Rader,Cornelia M. van Duijn,Leena Peltonen,Goncalo R. Abecasis,Michael Boehnke,Sekar Kathiresan, NATURE, NATURE PUBLISHING GROUP, Vol. 466, No. 7307, p. 707-713, 2010/08
  • Increased HDL Cholesterol and ApoA-I in Humans and Mice Treated With a Novel SR-BI Inhibitor, David Masson,Masahiro Koseki,Minako Ishibashi,Christopher J. Larson,Stephen G. Miller,Bernard D. King,Alan R. Tall, ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, LIPPINCOTT WILLIAMS & WILKINS, Vol. 29, No. 12, p. 2054-U170, 2009/12
  • Increased HDL Cholesterol and ApoA-I in Humans and Mice Treated With a Novel SR-BI Inhibitor, David Masson,Masahiro Koseki,Minako Ishibashi,Christopher J. Larson,Stephen G. Miller,Bernard D. King,Alan R. Tall, ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, LIPPINCOTT WILLIAMS & WILKINS, Vol. 29, No. 12, p. 2054-U170, 2009/12
  • Impaired Insulin Secretion in Four Tangier Disease Patients with ABCA1 Mutations, Masahiro Koseki,Akifumi Matsuyama,Kazuhiro Nakatani,Miwako Inagaki,Hajime Nakaoka,Ryota Kawase,Miyako Yuasa-Kawase,Kazumi Tsubakio-Yamamoto,Daisaku Masuda,Jose C. Sandoval,Tohru Ohama,Yumiko Nakagawa-Toyama,Fumihiko Matsuura,Makoto Nishida,Masato Ishigami,Ken-ichi Hirano,Naoki Sakane,Yoshitaka Kumon,Tadashi Suehiro,Tadashi Nakamura,Iichiro Shimomura,Shizuya Yamashita, JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, JAPAN ATHEROSCLEROSIS SOC, Vol. 16, No. 3, p. 292-296, 2009/06
  • Impaired Insulin Secretion in Four Tangier Disease Patients with ABCA1 Mutations, Masahiro Koseki,Akifumi Matsuyama,Kazuhiro Nakatani,Miwako Inagaki,Hajime Nakaoka,Ryota Kawase,Miyako Yuasa-Kawase,Kazumi Tsubakio-Yamamoto,Daisaku Masuda,Jose C. Sandoval,Tohru Ohama,Yumiko Nakagawa-Toyama,Fumihiko Matsuura,Makoto Nishida,Masato Ishigami,Ken-ichi Hirano,Naoki Sakane,Yoshitaka Kumon,Tadashi Suehiro,Tadashi Nakamura,Iichiro Shimomura,Shizuya Yamashita, JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, JAPAN ATHEROSCLEROSIS SOC, Vol. 16, No. 3, p. 292-296, 2009/06
  • Chylomicron remnants are increased in the postprandial state in CD36 deficiency, Daisaku Masuda,Ken-ichi Hirano,Hiroyuki Oku,Jose C. Sandoval,Ryota Kawase,Miyako Yuasa-Kawase,Yasushi Yamashita,Masanori Takada,Kazumi Tsubakio-Yamamoto,Yoshihiro Tochino,Masahiro Koseki,Fumihiko Matsuura,Makoto Nishida,Toshiharu Kawamoto,Masato Ishigami,Masatsugu Hori,Iichiro Shimomura,Shizuya Yamashita, JOURNAL OF LIPID RESEARCH, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, Vol. 50, No. 5, p. 999-1011, 2009/05
  • Chylomicron remnants are increased in the postprandial state in CD36 deficiency, Daisaku Masuda,Ken-ichi Hirano,Hiroyuki Oku,Jose C. Sandoval,Ryota Kawase,Miyako Yuasa-Kawase,Yasushi Yamashita,Masanori Takada,Kazumi Tsubakio-Yamamoto,Yoshihiro Tochino,Masahiro Koseki,Fumihiko Matsuura,Makoto Nishida,Toshiharu Kawamoto,Masato Ishigami,Masatsugu Hori,Iichiro Shimomura,Shizuya Yamashita, JOURNAL OF LIPID RESEARCH, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, Vol. 50, No. 5, p. 999-1011, 2009/05
  • Adiponectin prevents atherosclerosis by increasing cholesterol efflux from macrophages, Kazumi Tsubakio-Yamamoto,Fumihiko Matsuura,Masahiro Koseki,Hiroyuki Oku,Jose C. Sandoval,Miwako Inagaki,Kazuhiro Nakatani,Hajime Nakaoka,Ryota Kawase,Miyako Yuasa-Kawase,Daisaku Masuda,Tohru Ohama,Norikazu Maeda,Yumiko Nakagawa-Toyama,Masato Ishigami,Makoto Nishida,Shinji Kihara,Iichiro Shimomura,Shizuya Yamashita, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC ELSEVIER SCIENCE, Vol. 375, No. 3, p. 390-394, 2008/10
  • Adiponectin prevents atherosclerosis by increasing cholesterol efflux from macrophages, Kazumi Tsubakio-Yamamoto,Fumihiko Matsuura,Masahiro Koseki,Hiroyuki Oku,Jose C. Sandoval,Miwako Inagaki,Kazuhiro Nakatani,Hajime Nakaoka,Ryota Kawase,Miyako Yuasa-Kawase,Daisaku Masuda,Tohru Ohama,Norikazu Maeda,Yumiko Nakagawa-Toyama,Masato Ishigami,Makoto Nishida,Shinji Kihara,Iichiro Shimomura,Shizuya Yamashita, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC ELSEVIER SCIENCE, Vol. 375, No. 3, p. 390-394, 2008/10
  • Evaluation of a homogeneous assay for measuring LDL-cholesterol in hyperlipiclemic serum specimens, Shizuya Yamashita,Mitsuhiro Nakamura,Hiroaki Koizumi,Hiroyuki Oku,Jose C. Sandoval,Kazumi Tsubakio-Yamamoto,Miyako Kawase,Daisaku Masuda,Masahiro Koseki,Fumihiko Matsuura,Iichiro Shimomura,Makoto Nishida,Masato Ishigami, JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, JAPAN ATHEROSCLEROSIS SOC, Vol. 15, No. 2, p. 82-86, 2008/04
  • Evaluation of a homogeneous assay for measuring LDL-cholesterol in hyperlipiclemic serum specimens, Shizuya Yamashita,Mitsuhiro Nakamura,Hiroaki Koizumi,Hiroyuki Oku,Jose C. Sandoval,Kazumi Tsubakio-Yamamoto,Miyako Kawase,Daisaku Masuda,Masahiro Koseki,Fumihiko Matsuura,Iichiro Shimomura,Makoto Nishida,Masato Ishigami, JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, JAPAN ATHEROSCLEROSIS SOC, Vol. 15, No. 2, p. 82-86, 2008/04
  • Adiponectin deficiency suppresses ApoA-I synthesis in ABCA1 expression and the liver, Hiroyuki Oku,Fumihiko Matsuura,Masahiro Koseki,Jose C. Sandoval,Miyako Yuasa-Kawase,Kazumi Tsubakio-Yamamoto,Daisaku Masuda,Norikazu Maeda,Tohru Ohama,Masato Ishigami,Makoto Nishida,Ken-Ichi Hirano,Shinji Kihara,Masatsugu Hori,Iichiro Shimomura,Shizuya Yamashita, FEBS LETTERS, ELSEVIER SCIENCE BV, Vol. 581, No. 26, p. 5029-5033, 2007/10
  • Adiponectin deficiency suppresses ApoA-I synthesis in ABCA1 expression and the liver, Hiroyuki Oku,Fumihiko Matsuura,Masahiro Koseki,Jose C. Sandoval,Miyako Yuasa-Kawase,Kazumi Tsubakio-Yamamoto,Daisaku Masuda,Norikazu Maeda,Tohru Ohama,Masato Ishigami,Makoto Nishida,Ken-Ichi Hirano,Shinji Kihara,Masatsugu Hori,Iichiro Shimomura,Shizuya Yamashita, FEBS LETTERS, ELSEVIER SCIENCE BV, Vol. 581, No. 26, p. 5029-5033, 2007/10
  • Adiponectin accelerates reverse cholesterol transport by increasing high density lipoprotein assembly in the liver, Fumihiko Matsuura,Hiroyuki Oku,Masahiro Koseki,Jose C. Sandoval,Miyako Yuasa-Kawase,Kazumi Tsubakio-Yamamoto,Daisaku Masuda,Norikazu Maeda,Ken-ichi Tsujii,Masato Ishigami,Makoto Nishida,Ken-ichi Hirano,Shinji Kihara,Masatsugu Hori,Iichiro Shimomura,Shizuya Yamashita, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC ELSEVIER SCIENCE, Vol. 358, No. 4, p. 1091-1095, 2007/07
  • Adiponectin accelerates reverse cholesterol transport by increasing high density lipoprotein assembly in the liver, Fumihiko Matsuura,Hiroyuki Oku,Masahiro Koseki,Jose C. Sandoval,Miyako Yuasa-Kawase,Kazumi Tsubakio-Yamamoto,Daisaku Masuda,Norikazu Maeda,Ken-ichi Tsujii,Masato Ishigami,Makoto Nishida,Ken-ichi Hirano,Shinji Kihara,Masatsugu Hori,Iichiro Shimomura,Shizuya Yamashita, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC ELSEVIER SCIENCE, Vol. 358, No. 4, p. 1091-1095, 2007/07
  • Senescent phenotypes of skin fibroblasts from patients with Tangier disease, Fumihiko Matsuura,Ken-ichi Hirano,Chiaki Ikegami,Jose C. Sandoval,Hiroyuki Oku,Miyako Yuasa-Kawase,Kazumi Tsubakio-Yamamoto,Masahiro Koseki,Daisaku Masuda,Ken-ichi Tsujii,Masato Ishigami,Makoto Nishida,Iichiro Shimomura,Masatsugu Hori,Shizuya Yamashita, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC ELSEVIER SCIENCE, Vol. 357, No. 2, p. 493-498, 2007/06
  • Senescent phenotypes of skin fibroblasts from patients with Tangier disease, Fumihiko Matsuura,Ken-ichi Hirano,Chiaki Ikegami,Jose C. Sandoval,Hiroyuki Oku,Miyako Yuasa-Kawase,Kazumi Tsubakio-Yamamoto,Masahiro Koseki,Daisaku Masuda,Ken-ichi Tsujii,Masato Ishigami,Makoto Nishida,Iichiro Shimomura,Masatsugu Hori,Shizuya Yamashita, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC ELSEVIER SCIENCE, Vol. 357, No. 2, p. 493-498, 2007/06
  • OE-079 HDL-mediated Plaque Stabilization through Enhancement of Cholesterol Efflux and Inhibition of a Novel Proinflammatory Cytokine Proepithelin(Atherosclerosis, basic-1, The 71st Annual Scientific Meeting of the Japanese Circulation Society), Yamashita Shizuya,Matsuyama Akifumi,Koseki Masahiro,Masuda Daisaku,Matsuura Fumihiko,Hirano Kenichi,Hori Masatsugu,Shimomura Iichiro, Circulation journal : official journal of the Japanese Circulation Society, 社団法人日本循環器学会, Vol. 71, No. 0, 2007/03/01
  • Increased lipid rafts and accelerated lipopolysaccharide-induced tumor necrosis factor-alpha secretion in Abca1-deficient macrophages, Masahiro Koseki,Ken-ichi Hirano,Daisaku Masuda,Chiaki Ikegami,Masaki Tanaka,Akemi Ota,Jose C. Sandoval,Yumiko Nakagawa-Toyama,Satoshi B. Sato,Toshihide Kobayashi,Yukiko Shimada,Yoshiko Ohno-Iwashita,Fumihiko Matsuura,Iichiro Shimomura,Shizuya Yamashita, JOURNAL OF LIPID RESEARCH, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, Vol. 48, No. 2, p. 299-306, 2007/02
  • Increased lipid rafts and accelerated lipopolysaccharide-induced tumor necrosis factor-alpha secretion in Abca1-deficient macrophages, Masahiro Koseki,Ken-ichi Hirano,Daisaku Masuda,Chiaki Ikegami,Masaki Tanaka,Akemi Ota,Jose C. Sandoval,Yumiko Nakagawa-Toyama,Satoshi B. Sato,Toshihide Kobayashi,Yukiko Shimada,Yoshiko Ohno-Iwashita,Fumihiko Matsuura,Iichiro Shimomura,Shizuya Yamashita, JOURNAL OF LIPID RESEARCH, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, Vol. 48, No. 2, p. 299-306, 2007/02
  • OE-060 Apo B-48 Is a Good Marker for Coronary Risk and Impaired Metabolism of Chylomicron Remnants in Subjects with Metabolic Syndrome(Lipid disorders-1 (H) OE10,Oral Presentation (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Ci, Yamashita Shizuya,Sugimoto Taizo,Nishida Makoto,Ishigami Masato,Kirino Motohiro,Masuda Daisaku,Koseki Masahiro,Toyama Yumiko,Matsuyama Akifumi,Hirano Ken-ichi,Hori Masatsugu,Sakai Naohiko,Matsumoto Kengo,Kawamoto Toshiharu,Uchida Yoshiaki, Circulation journal : official journal of the Japanese Circulation Society, 社団法人日本循環器学会, Vol. 70, No. 0, 2006/03/01
  • Accumulation of chylomicron remnants in diabetic patients in relation to coronary heart disease - Analysis by a novel ELISA for apo B-48, S. Yamashita,T. Sugimoto,K. Tsujii,M. Koseki,M. Nishida,K. Hirano,I. Shimomura,Y. Uchida,N. Sakai, ADVANCES IN HEART DISEASE, MEDIMOND S R L, p. 305-+, 2006
  • Probucol enhances the expression of human hepatic scavenger receptor class B type I, possibly through a species-specific mechanism, K Hirano,C Ikegami,K Tsujii,ZY Zhang,F Matsuura,Y Nakagawa-Toyama,M Koseki,D Masuda,T Maruyama,Shimomura, I,Y Ueda,S Yamashita, ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, LIPPINCOTT WILLIAMS & WILKINS, Vol. 25, No. 11, p. 2422-2427, 2005/11
  • Probucol enhances the expression of human hepatic scavenger receptor class B type I, possibly through a species-specific mechanism, K Hirano,C Ikegami,K Tsujii,ZY Zhang,F Matsuura,Y Nakagawa-Toyama,M Koseki,D Masuda,T Maruyama,Shimomura, I,Y Ueda,S Yamashita, ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, LIPPINCOTT WILLIAMS & WILKINS, Vol. 25, No. 11, p. 2422-2427, 2005/11
  • Familial massive tendon xanthomatosis with decreased high-density lipoprotein-mediated cholesterol efflux, F Matsuura,K Hirano,M Koseki,T Ohama,A Matsuyama,K Tsujii,R Komuro,M Nishida,N Sakai,H Hiraoka,T Nakamura,S Yamashita, METABOLISM-CLINICAL AND EXPERIMENTAL, W B SAUNDERS CO, Vol. 54, No. 8, p. 1095-1101, 2005/08
  • Familial massive tendon xanthomatosis with decreased high-density lipoprotein-mediated cholesterol efflux, F Matsuura,K Hirano,M Koseki,T Ohama,A Matsuyama,K Tsujii,R Komuro,M Nishida,N Sakai,H Hiraoka,T Nakamura,S Yamashita, METABOLISM-CLINICAL AND EXPERIMENTAL, W B SAUNDERS CO, Vol. 54, No. 8, p. 1095-1101, 2005/08
  • Defective cholesterol efflux in Werner syndrome fibroblasts and its phenotypic correction by Cdc42, a RhoGTPase, ZY Zhang,K Hirano,K Tsukamoto,C Ikegami,M Koseki,K Saijo,T Ohno,N Sakai,H Hiraoka,L Shimomura,S Yamashita, EXPERIMENTAL GERONTOLOGY, PERGAMON-ELSEVIER SCIENCE LTD, Vol. 40, No. 4, p. 286-294, 2005/04
  • Defective cholesterol efflux in Werner syndrome fibroblasts and its phenotypic correction by Cdc42, a RhoGTPase, ZY Zhang,K Hirano,K Tsukamoto,C Ikegami,M Koseki,K Saijo,T Ohno,N Sakai,H Hiraoka,L Shimomura,S Yamashita, EXPERIMENTAL GERONTOLOGY, PERGAMON-ELSEVIER SCIENCE LTD, Vol. 40, No. 4, p. 286-294, 2005/04
  • Mechanical ventricular assist system required for sustained severe cardiac dysfunction secondary to peripartum cardiomyopathy, O Monta,G Matsumiya,N Fukushima,Y Miyamoto,Y Sawa,M Koseki,Nakamichi, I,H Matsuda, CIRCULATION JOURNAL, BLACKWELL PUBLISHING ASIA, Vol. 69, No. 3, p. 362-364, 2005/03
  • Mechanical ventricular assist system required for sustained severe cardiac dysfunction secondary to peripartum cardiomyopathy, O Monta,G Matsumiya,N Fukushima,Y Miyamoto,Y Sawa,M Koseki,Nakamichi, I,H Matsuda, CIRCULATION JOURNAL, BLACKWELL PUBLISHING ASIA, Vol. 69, No. 3, p. 362-364, 2005/03
  • Vesicular Acidification Is Required for ATP-Binding Cassette Transporter A1-Mediated Cholesterol Efflux, Koseki Masahiro,Matsuyama Akifumi,Sakai Naohiko,Ohama Toru,Nishida Yoshiharu,Hirano Kenichi,Hiraoka Hisatoyo,Nakamura Tadashi,Yamashita Shizuya,Matsuzawa Yuji, Circulation journal : official journal of the Japanese Circulation Society, 社団法人日本循環器学会, Vol. 67, No. 0, 2003/03/01
  • Measurement of Cholesterol Efflux from Monocyte-Derived Macrophages of Patients with Llpid Disorders and Atherosclerotic Cardiovascular Diseases, Tsujii Kenichi,Hirano Kenichi,Zhang Zhongyan,Matsuura Fumihiko,Ohama Tohru,Kuwasako Takahiro,Koseki Masahiro,Matsuyama Akifumi,Tsukamoto Kosuke,Toyama Yumiko,Tachibana Koichi,Ishigami Masato,Sakai Naohiko,Hiraoka Hisatoyo,Nakamura Tadashi,Yamashita Shizuya,Matsuzawa Yuji, Circulation journal : official journal of the Japanese Circulation Society, 社団法人日本循環器学会, Vol. 67, No. 0, 2003/03/01
  • C-Reactive Protein-Mediated Low-Density Lipoprotein Uptake by Human Monocyte-Derived Macrophages : Implications in Atherogenesis, Matsuyama Akifumi,Sakai Naohiko,Koseki Masahiro,Sugimoto Taizo,Hiraoka Hisatoyo,Nakamura Tadashi,Yamashita Shizuya,Matsuzawa Yuji, Circulation journal : official journal of the Japanese Circulation Society, 社団法人日本循環器学会, Vol. 67, No. 0, p. 152-153, 2003/03/01

Misc.

  • 非アルコール性脂肪性肝疾患(NAFLD)は心血管疾患を合併しやすい? 心血管疾患の合併に注意が必要, No. 5025, p. 50-50, 2020/08
  • NAFLDと脂肪酸との関係は? 脂肪酸はNAFLDの成因のひとつであり、NAFLD outcomeであるCVD発症にも寄与する, No. 5026, p. 45-46, 2020/08
  • 脂質代謝研究の進歩 NAFLD/NASH、動脈硬化進展における外因性酸化ステロール7-ketocholesterolの影響, Vol. 52回, p. 124-124, 2020/07
  • ムーンショットプロジェクト-来たれ迷える大学院生最新研究TECH-Seminar- 次世代シークエンサーと原発性脂質異常症診断パネルを用いた遺伝子診断の実際, Vol. 52回, p. 129-129, 2020/07
  • 心血管疾患のリスク病態としてのNAFLD/NASH 都市部地域住民を対象としたFIB-4インデックスと循環器病発症との関係 吹田研究, Vol. 52回, p. 155-155, 2020/07
  • 心血管疾患のリスク病態としてのNAFLD/NASH 動脈硬化惹起食誘導脂肪肝炎モデルにおける、ペマフィブラートの抗脂肪肝炎、抗心筋炎症作用の解明, Vol. 52回, p. 157-157, 2020/07
  • Targeted Exon Sequencing of Lipid-Related Genes in Patients with Familial Hypercholesterolemia(和訳中), 岡田 健志,小関 正博,西田 誠,乾 洋勉,冠野 昂太郎,嵯峨 礼美,大濱 透,鯨岡 健,服部 浩明,山下 静也,坂田 泰史, 日本動脈硬化学会総会プログラム・抄録集, (一社)日本動脈硬化学会, Vol. 52回, p. 202-202, 2020/07
  • 非高密度リポ蛋白コレステロールと経皮的冠動脈形成術後の主要心血管事故の関連の検証, Vol. 52回, p. 259-259, 2020/07
  • 食餌誘発性脂肪肝炎マウスモデルにおいて7-ketocholesterolはイミキモド誘導乾癬様皮膚炎を増悪させる, Vol. 52回, p. 280-280, 2020/07
  • 食事由来7-ketocholesterolは、Ldl受容体欠損マウスにおいて、脂肪肝炎とアテローム性動脈硬化症を増悪させる, Vol. 62, p. 161-161, 2020/05
  • 食餌誘導性脂肪肝炎マウスモデルにおいて7-ketocholesterolは乾癬様皮膚炎を促進させる, Vol. 62, p. 163-163, 2020/05
  • 食餌由来7-ketocholesterolが糖尿病モデルラットの左室の収縮能、拡張能に及ぼす影響の検討, Vol. 62, p. 164-164, 2020/05
  • 血清7-ketocholesterol濃度は7年後の肝機能異常を予測する, Vol. 62, p. 165-165, 2020/05
  • 【NAFLD/NASHの進歩と新たな展開】最新の治療薬・治験薬の状況, Vol. 7, No. 5, p. 438-445, 2020/05
  • 著明な高LDL-C血症をきたした小児症例における食事指導の重要性, Vol. 31, No. 1, p. 90-90, 2020/04
  • NAFLDの病態解明及び新規治療法の探索 食事由来酸化ステロール蓄積のNAFLD,動脈硬化の進展における影響, Vol. 61, No. Suppl.1, p. A216-A216, 2020/04
  • 食餌誘導性肝線維化モデルにおけるペマフィブラートの肝臓,心臓への作用メカニズムの解明, Vol. 61, No. Suppl.1, p. A303-A303, 2020/04
  • イミキモド誘導乾癬モデルマウスにおける食事誘導性脂肪肝炎の影響, Vol. 61, No. Suppl.1, p. A322-A322, 2020/04
  • 著明な低HDLコレステロール血症をきたす原発性脂質異常症の臨床的特徴と鑑別, Vol. 109, No. Suppl., p. 238-238, 2020/02
  • 著明な低HDLコレステロール血症をきたす原発性脂質異常症の臨床的特徴と鑑別, Vol. 46, p. 69-69, 2020/01
  • 著明な高トリグリセリド血症をきたす原発性脂質異常症に対する食事療法と薬物療法, Vol. 46, p. 70-70, 2020/01
  • 脂質の違いが引き起こすImmunometabolic Disorders 動脈硬化症とNAFLD/NASH, Vol. 46, p. 70-70, 2020/01
  • 当科脂質外来における家族性高コレステロール血症診療の現状, Vol. 46, p. 71-71, 2020/01
  • CETP欠損症リポ蛋白の動脈硬化惹起性に関する検討, Vol. 46, p. 71-71, 2020/01
  • 非高密度リポ蛋白コレステロールと経皮的冠動脈形成術後の主要心血管事故の関連の検証, Vol. 46, p. 72-72, 2020/01
  • HDL結合蛋白ProgranulinのACSにおける役割, Vol. 46, p. 84-84, 2020/01
  • 隠れ脂肪肝や酸化コレステロールが危ない "隠れ脂肪肝"と動脈硬化リスク, Vol. 41, No. 1, p. 9-10, 2020/01
  • HDL-コレステロールが著しく低い症例で注意することは? LCAT欠損症、魚眼病、タンジール病、アポリポ蛋白質A-1欠損症等の遺伝性疾患に注意, No. 4983, p. 53-53, 2019/10
  • 脂質異常症難病のすべてがわかる! 低HDL-C血症の診断の進め方 LCAT欠損症とタンジール病, Vol. 51回, p. S12-4, 2019/07
  • 心血管疾患のリスク病態としてのNAFLD/NASH NAFLD/NASHの現状と治療薬開発の現状, Vol. 51回, p. GS1-1, 2019/07
  • 心血管疾患のリスク病態としてのNAFLD/NASH NAFLD/NASH進展における外因性酸化ステロールの影響の検討, Vol. 51回, p. GS1-5, 2019/07
  • 高コレステロール食誘発心筋梗塞モデルマウスにおけるT細胞の関与の検討, Vol. 51回, p. 1-5, 2019/07
  • 乾癬様皮膚炎マウスモデルにおける外因性酸化ステロールの影響の検討, Vol. 51回, p. 1-5, 2019/07
  • 新規食餌誘導性非アルコール性脂肪肝炎マウスモデルにおけるPemafibrateの作用機序の検討, Vol. 51回, p. 1-4, 2019/07
  • 当科脂質外来における家族性高コレステロール血症診療の現状, Vol. 51回, p. 1-2, 2019/07
  • 脂質異常症難病のすべてがわかる! 低HDL-C血症の診断の進め方 LCAT欠損症とタンジール病, Vol. 51回, p. S12-4, 2019/07
  • 【循環器疾患+αを考える!他領域疾患併発患者への治療戦略】識る NAFLD/NASHを合併した心血管疾患, Vol. 23, No. 3, p. 256-261, 2019/03
  • 【動脈硬化UPDATE】基礎 NAFLD/NASHと動脈硬化をつなぐ分子メカニズム, Vol. 268, No. 5, p. 369-373, 2019/02
  • 【脂質異常症 新たな時代に入った脂質異常症治療をふまえて】重症家族性高コレステロール血症に対する根治的治療法の開発 同種脂肪組織由来多系統前駆細胞移植療法, Vol. 36, No. 1, p. 105-108, 2019/01
  • 【原発性高脂血症研究の過去・現在・未来】タンジール病の過去・現在・未来, Vol. 30, No. 1, p. 79-86, 2019/01
  • 家族性高コレステロール血症ホモ接合体に対する同種脂肪組織由来幹細胞移植療法, 小関正博,嵯峨礼美,冠野昂太郎,岡田健志,朝治真澄,冨田興一,大須賀慶悟,江副幸子,西田誠,西田誠,坂田泰史,山下静也,山下静也, 日本再生医療学会総会(Web), Vol. 18th, 2019
  • NAFLD/NASHと動脈硬化症〜基礎研究の最前線〜 NAFLD/NASHと動脈硬化症をつなぐ分子メカニズムは何か, Vol. 50回, p. 140-140, 2018/06
  • NAFLD/NASHと動脈硬化症〜臨床的観点から〜 NASH治療薬のパイプライン, Vol. 50回, p. 146-146, 2018/06
  • 腸管吸収に着目した治療戦略 腸管上皮細胞のコレステロールトランスポーターNPC1L1と核内受容体LXRを識る, Vol. 50回, p. 167-167, 2018/06
  • 高コレステロール食誘発心筋梗塞モデルマウスにおける血球系細胞の関与, Vol. 50回, p. 268-268, 2018/06
  • 10年間の腹囲・BMIの変動と危険因子、生活習慣の関連, Vol. 50回, p. 345-345, 2018/06
  • 重症家族性高コレステロール血症に対する再生医療の臨床応用, 冠野昂太郎,小関正博,嵯峨礼美,岡田健志,朝治真澄,冨田興一,大須賀慶悟,江副幸子,西田誠,西田誠,坂田泰史,山下静也,山下静也,山下静也, 日本動脈硬化学会総会・学術集会プログラム・抄録集(Web), Vol. 50回, p. 153-153, 2018/06
  • 家族性高コレステロール血症ホモ接合体に対する同種脂肪組織由来幹細胞移植療法の開発の現状, 小関正博,嵯峨礼美,冠野昂太郎,岡田健志,朝治真澄,冨田興一,大須賀慶悟,江副幸子,西田誠,西田誠,坂田泰史,山下静也,山下静也,山下静也, 日本動脈硬化学会総会・学術集会プログラム・抄録集(Web), (一社)日本動脈硬化学会, Vol. 50回, p. 219-219, 2018/06
  • FHにおける既知および未知の機序を通したアテローム生成(Atherogenicity through Known and Unknown Mechanisms in FH), 小関 正博, 日本循環器学会学術集会抄録集, (一社)日本循環器学会, Vol. 82回, p. TP3-6, 2018/03
  • 医歯薬学部学生における麻疹、風疹、水痘、流行性耳下腺炎、B型肝炎ワクチンの有効性, Vol. 55, No. 1, p. 231-231, 2018/03
  • ストレスチェック開始後1年間の取り組みのまとめと現状報告, 川村淳子,足立浩祥,明石美智子,熊谷一代,村井教子,姫ヶ迫由美,金山大祐,西田誠,山本陵平,小関正博,中西香織,岡久仁洋,瀧原圭子,工藤喬,守山敏樹, 全国大学保健管理研究集会プログラム・抄録集, Vol. 55, No. 1, p. 421-422, 2018/03
  • 重症家族性高コレステロール血症に対する再生医療・細胞治療の臨床応用, 岡田健志,小関正博,嵯峨礼美,嵯峨礼美,冠野昂太郎,冨田興一,大須賀慶悟,川本弘一,江副幸子,西田誠,坂田泰史,山下静也,山下静也, 日本再生医療学会総会(Web), Vol. 17th, 2018
  • 核内受容体が制御する多彩な生命現象 LXRαの新規調節機構 TTC39B阻害はLXRαのユビキチン化によるプロテアソーム分解を減弱させアテローム性動脈硬化症および非アルコール性脂肪性肝炎の両方を改善する, Vol. 2017年度, p. [2AW03-4], 2017/12
  • 医歯薬学部学生における麻疹、風疹、水痘、流行性耳下腺炎、B型肝炎ワクチンの有効性, Vol. 55回, p. 82-82, 2017/11
  • ストレスチェック開始後1年間の取り組みのまとめと現状報告, Vol. 55回, p. 121-121, 2017/11
  • SHOTGUN PROTEOMICS ANALYSIS CHARACTERIZES HDL PROTEOME IN PATIENTS WITH CHOLESTERYL ESTER TRANSFER PROTEIN DEFICIENCY, Takeshi Okada,Tohru Ohama,Kotaro Kanno,Hibiki Matsuda,Masami Sairyo,Yinghong Zhu,Ayami Saga,Takuya Kobayashi,Daisaku Masuda,Masahiro Koseki,Makoto Nishida,Yasushi Sakata,Shizuya Yamashita, ATHEROSCLEROSIS, ELSEVIER IRELAND LTD, Vol. 263, p. E3-E4, 2017/08
  • MECHANISM OF SHORT TERM FRUCTOSE EXPOSURE INDUCED CHYLOMICRON SECRETION, Takuya Kobayashi,Daisaku Masuda,Masami Sairyo,Takeshi Okada,Masahiro Koseki,Tohru Ohama,Makoto Nishida,Yasushi Sakata,Shizuya Yamashita, ATHEROSCLEROSIS, ELSEVIER IRELAND LTD, Vol. 263, p. E209-E210, 2017/08
  • DEVELOPMENT OF ENZYME-LINKED IMMUNOSORBENT ASSAY FOR OXIDIZED HIGH DENSITY LIPOPROTEIN AND ITS CLINICAL APPLICATION FOR CARDIOVASCULAR RISK ASSESSMENT, Takeshi Okada,Tohru Ohama,Mizuki Sumida,Yuki Katayama,Kotaro Kanno,Hibiki Matsuda,Masami Sairyo,Yinghong Zhu,Ayami Saga,Takuya Kobayashi,Daisaku Masuda,Masahiro Koseki,Makoto Nishida,Norihiko Kayahara,Yasushi Sakata,Shizuya Yamashita, ATHEROSCLEROSIS, ELSEVIER IRELAND LTD, Vol. 263, p. E96-E96, 2017/08
  • ANALYSIS OF SELECTIVELY ISOLATED CHYLOMICRON REMNANTS IN VARIOUS CONDITIONS, Masuda Daisaku,Takuya Kobayashi,Masami Sairyo,Takeshi Okada,Masahiro Koseki,Tohru Ohama,Makoto Nishida,Yasushi Sakata,Shizuya Yamashita, ATHEROSCLEROSIS, ELSEVIER IRELAND LTD, Vol. 263, p. E210-E210, 2017/08
  • THE ROLE OF TTC39B IN ATHEROSCLEROSIS AND NON-ALCOHOLIC STEATOHEPATITIS, Masahiro Koseki,Joanne Hsieh,Matthew Molusky,Emi Yakushiji,Marit Westerterp,Ikuyo Ichi,Sandra Abramowicz,Liana Tascau,Carrie Welch,Shunichi Takiguchi,Jahangir Iqbal,Yasushi Sakata,Shizuya Yamashita,Mahmood Hussain,Daniel Rader,Alan Tall, ATHEROSCLEROSIS, ELSEVIER IRELAND LTD, Vol. 263, p. E82-E83, 2017/08
  • 新入生健診時メンタルヘルスチェック(2014〜16年)の年次比較, Vol. 54, No. 1, p. 405-405, 2017/03
  • 10年間のBMI・腹囲増減に伴う健康障害と生活習慣の関連, Vol. 54, No. 1, p. 102-104, 2017/03
  • 大阪大学におけるストレスチェックの取り組みと現状報告(第一報), 川村 淳子,足立 浩祥,明石 美智子,金山 大祐,福森 亮雄,水田 一郎,石金 直美,竹中 菜苗,稲月 聡子,西田 誠,山本 陵平,小関 正博,中西 香織,岡久 仁洋,守山 敏樹,工藤 喬,瀧原 圭子, CAMPUS HEALTH, (公社)全国大学保健管理協会, Vol. 54, No. 1, p. 262-262, 2017/03
  • 新入生健診時メンタルヘルスチェック(2014〜16年)の年次比較, 稲月 聡子,足立 由美,水田 一郎,石金 直美,竹中 菜苗,工藤 喬,足立 浩祥,金山 大祐,福森 亮雄,守山 敏樹,西田 誠,山本 陵平,小関 正博,中西 香織,岡 久仁洋,瀧原 圭子, CAMPUS HEALTH, (公社)全国大学保健管理協会, Vol. 54, No. 1, p. 405-405, 2017/03
  • Ttc39b Deficiency Attenuates Atherosclerosis and Hepatic Steatosis Through Lxra Dependent Manner, Masahiro Koseki,Joanne Heish,Matthew M. Molusky,Emi Yakushiji,Marit Westerterp,Ikuyo Ichi,Sandra Abramowicz,Liana Tascau,Carrie B. Welch,Shunichi Takiguchi,Jahangir Iqbal,Yasushi Sakata,Shizuya Yamashita,Mahmood M. Hussain,Daniel J. Rader,Alan R. Tall, CIRCULATION, LIPPINCOTT WILLIAMS & WILKINS, Vol. 134, 2016/11
  • A DPP-4 Inhibitor, Anagliptin, Attenuates Both Fasting and Postprandial Hypertriglyceridemia, Masami Sairyo,Daisaku Masuda,Takuya Kobayashi,Kotaro Kanno,Hibiki Matsuda,Takeshi Okada,Tohru Ohama,Masahiro Koseki,Makoto Nishida,Yasushi Sakata,Shizuya Yamashita, CIRCULATION, LIPPINCOTT WILLIAMS & WILKINS, Vol. 134, 2016/11
  • Proteomic Analysis of Atherogenic Chylomicron Remnants Isolated Selectively From Human Serum, Daisaku Masuda,Takuya Kobayashi,Masami Sairyou,Takeshi Okada,Masahiro Koseki,Tohru Ohama,Makoto Nishida,Yasushi Sakata,Shizuya Yamashita, CIRCULATION, LIPPINCOTT WILLIAMS & WILKINS, Vol. 134, 2016/11
  • DPP4 INHIBITOR, ANAGLIPTIN, AMELIORATES FASTING AND POSTPRANDIAL HYPERTRIGLYCERIDEMIA, M. Sairyo,D. Masuda,T. Kobayashi,H. Matsuda,T. Okada,R. Kawase,K. Nakatani,M. Koseki,T. Ohama,M. Nishida,Y. Sakata,S. Yamashita, ATHEROSCLEROSIS, ELSEVIER IRELAND LTD, Vol. 252, p. E213-E213, 2016/09
  • HIGH-PERFORMANCE GEL PERMEATION CHROMATOGRAPHY ANALYSIS DEMONSTRATES ATHEROGENIC PROPERTIES OF LIPOPROTEINS IN PATIENTS WITH CHOLESTERYL ESTER TRANSFER PROTEIN DEFICIENCY, T. Okada,T. Ohama,M. Okazaki,H. Matsuda,M. Sairyo,Y. Zhu,R. Kawase,D. Masuda,M. Koseki,M. Nishida,Y. Sakata,S. Yamashita, ATHEROSCLEROSIS, ELSEVIER IRELAND LTD, Vol. 252, p. E118-E118, 2016/09
  • 新入生健診時メンタルヘルスチェックの年次比較, 稲月聡子,足立由美,足立由美,水田一郎,石金直美,竹中菜苗,工藤喬,足立浩祥,金山大祐,福森亮雄,守山敏樹,西田誠,山本陵平,小関正博,中西香織,岡久仁洋,瀧原圭子, 全国大学保健管理研究集会プログラム・抄録集, (公社)全国大学保健管理協会, Vol. 54th, p. 110-110, 2016/09
  • 大阪大学におけるストレスチェックの取り組みと現状報告(第一報), 川村淳子,明石美智子,足立浩祥,金山大祐,福森亮雄,水田一郎,石金直美,竹中菜苗,西田誠,山本陵平,小関正博,中西香織,岡久仁洋,守山敏樹,工藤喬,瀧原圭子, 全国大学保健管理研究集会プログラム・抄録集, (公社)全国大学保健管理協会, Vol. 54th, p. 75-75, 2016/09
  • DPP-4 Inhibitor, Anagliptin, Ameliorates Fasting and Postprandial Hypertriglyceridemia, Masami Sairyo,Daisaku Masuda,Takuya Kobayashi,Hibiki Matsuda,Takeshi Okada,Ryota Kawase,Kazuhiro Nakatani,Masahiro Koseki,Tohru Ohama,Makoto Nishida,Yasushi Sakata,Shizuya Yamashita, DIABETES, AMER DIABETES ASSOC, Vol. 65, p. A28-A28, 2016/06
  • Proteomic Analysis and Comparison of Selectively-isolated Apolipoprotein B48-and B100-containing Lipoproteins in Human Serum, Takuya Kobayashi,Daisaku Masuda,Masami Sairyo,Takeshi Okada,Ryota Kawase,Kazuhiro Nakatani,Masahiro Koseki,Tohru Ohama,Makoto Nishida,Yasushi Sakata,Shizuya Yamashita, DIABETES, AMER DIABETES ASSOC, Vol. 65, p. A160-A160, 2016/06
  • 重症家族性高コレステロール血症に対する新しい細胞移植治療法の開発と臨床応用, 小関正博,小関正博,嵯峨礼美,嵯峨礼美,岡田健志,川瀬良太,小林卓哉,朝治真澄,冨田興一,大須賀慶悟,川本弘一,江副幸子,西田誠,西田誠,坂田泰史,山下静也,山下静也, 再生医療, Vol. 15, 2016/02/01
  • 重症家族性高コレステロール血症に対する新しい細胞移植治療法の開発と臨床応用, 小関 正博,嵯峨 礼美,岡田 健志,川瀬 良太,小林 卓哉,朝治 真澄,江副 幸子,西田 誠,坂田 泰史,山下 静也, 日本内科学会雑誌, (一社)日本内科学会, Vol. 105, No. Suppl., p. 257-257, 2016/02
  • AN OPEN-LABEL, PHASE I TRIAL OF TRANSPLANTATION THERAPY WITH ALLOGENEIC ADIPOSE TISSUE-DERIVED MULTILINEAGE PROGENITOR CELLS IN HOMOZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA PATIENTS, M. Koseki,S. Yamashita, ATHEROSCLEROSIS, ELSEVIER IRELAND LTD, Vol. 241, No. 1, p. E111-E111, 2015/07
  • DPP-4 Inhibitor, Sitagliptin, Improves the Accumulation of Remnant Lipoproteins in Patients with Type 2 Diabetes Mellitus (GLORIA Study), Daisaku Masuda,Takuya Kobayashi,Masami Sairyou,Takeshi Okada,Hajime Nakaoka,Ryota Kawase,Kazuhiro Nakatani,Tohru Ohama,Masahiro Koseki,Makoto Nishida,Yasushi Sakata,Shizuya Yamashita, DIABETES, AMER DIABETES ASSOC, Vol. 64, p. A176-A177, 2015/06
  • 我が国の原発性高脂血症の現状と未来 家族性高コレステロール血症に対する新しい治療法の開発と臨床応用, 小関 正博,嵯峨 礼美,江副 幸子,小林 卓哉,朝治 真澄,松田 響,朱 頴こう,岡田 健志,西良 雅己,中谷 和弘,川瀬 良太,増田 大作,大濱 透,西田 誠,冨田 興一,細川 亙,大須賀 慶悟,富山 憲幸,川本 弘一,伊藤 壽記,柳 光司,市 育代,森山 博由,早川 堯夫,荒井 秀典,斯波 真理子,坂田 泰史,山下 静也, 日本動脈硬化学会総会プログラム・抄録集, (一社)日本動脈硬化学会, Vol. 47回, p. 113-113, 2015/06
  • A Role of an HDL-associated Anti-inflammatory Protein, Progranulin, in Acute Coronary Syndrome, Ryota Kawase,Tohru Ohama,Masaya Morita,Yuma Kurozumi,Noritoshi Ito,Takeshi Okada,Daisaku Masuda,Masahiro Koseki,Makoto Nishida,Hirotaka Sawano,Yasuharu Doi,Yasushi Sakata,Shizuya Yamashita, CIRCULATION, LIPPINCOTT WILLIAMS & WILKINS, Vol. 130, 2014/11
  • Proteomic Analysis of Chylomicron Remnants Isolated by Apolipoprotein B-48 Immunoprecipitation, Daisaku Masuda,Takuya Kobayashi,Manabu Okubo,Takeshi Okada,Hajime Nakaoka,Ryota Kawase,Kazuhiro Nakatani,Tohru Ohama,Masahiro Koseki,Hiroyuki Hanada,Makoto Nishida,Yasushi Sakata,Shizuya Yamashita, CIRCULATION, LIPPINCOTT WILLIAMS & WILKINS, Vol. 130, 2014/11
  • Ttc39b Deficiency Has a Beneficial Role on Cholesterol and Triglyceride Absorption in Enterocytes, Masahiro Koseki,Joanne Hsieh,Emi Yakushiji,Carrie Welch,Jahangir Lqbal,Mahmood M. Hussain,Alan R. Tall,Yasushi Sakata,Shizuya Yamashita, CIRCULATION, LIPPINCOTT WILLIAMS & WILKINS, Vol. 130, 2014/11
  • A novel potent and selective PPARalpha agonist, K-877, ameriolates the atherogenic profile of fasting and postprandial hypertriglyceridemia in mice, D. Masuda,T. Kobayashi,H. Nakaoka,R. Kawase,K. Nakatani,M. Koseki,T. Ohama,M. Nishida,Y. Sakata,S. Yamashita, EUROPEAN HEART JOURNAL, OXFORD UNIV PRESS, Vol. 35, p. 904-904, 2014/09
  • Association of high serum apolipoprotein B-48 Level with increased proteinuria and reduced estimated glomerular filtration rate (eGFR), D. Masuda,M. Okubo,H. Hanada,M. Koseki,T. Ohama,M. Nishida,M. Matsui,Y. Hidaka,Y. Sakata,S. Yamashita, EUROPEAN HEART JOURNAL, OXFORD UNIV PRESS, Vol. 35, p. 217-218, 2014/09
  • A NOVEL POTENT AND SELECTIVE PPARALPHA AGONIST, K-877, AMERIOLATES BOTH FASTING AND POSTPRANDIAL HYPERTRIGLYCERIDEMIA, D. Masuda,T. Kobayashi,T. Okada,H. Nakaoka,R. Kawase,K. Nakatani,M. Koseki,T. Ohama,M. Nishida,Y. Sakata,S. Yamashita, ATHEROSCLEROSIS, ELSEVIER IRELAND LTD, Vol. 235, No. 2, p. E169-E170, 2014/08
  • EICOSAPENTAENOIC ACID AMERIOLATES POSTPRANDIAL HYPERTRIGLYCERIDEMIA, D. Masuda,T. Kobayashi,T. Okada,H. Nakaoka,R. Kawase,K. Nakatani,M. Koseki,T. Ohama,M. Nishida,Y. Sakata,S. Yamashita, ATHEROSCLEROSIS, ELSEVIER IRELAND LTD, Vol. 235, No. 2, p. E104-E105, 2014/08
  • Linagliptin Improves the Prognosis of Ischemic Cardiomyopathy in a New Murine Model of Diet-induced Myocardial Infarction, Hajime Nakaoka,Makoto Nishida,Yumiko Nakagawa-Toyama,Takashi Okada,Ryota Kawase,Kazuhiro Nakatani,Daisaku Masuda,Tohru Ohama,Masahiro Koseki,Shizuya Yamashita, DIABETES, AMER DIABETES ASSOC, Vol. 63, p. A295-A296, 2014/06
  • DPP-4 Inhibitor, Anagliptin, Ameriolates Both Fasting and Postprandial Hypertriglyceridemia, Daisaku Masuda,Takuya Kobayashi,Takeshi Okada,Hajime Nakaoka,Ryota Kawase,Kazuhiro Nakatani,Masahiro Koseki,Tohru Ohama,Makoto Nishida,Yasushi Sakata,Shizuya Yamashita, DIABETES, AMER DIABETES ASSOC, Vol. 63, p. A55-A55, 2014/06
  • Ttc39b Deficiency Causes an Intestinal Lxr Activation Phenotype With Increased Expression Of Abca1 and HDL-Cholesterol Levels, Masahiro Koseki,Joanne Hsieh,Emi Yakushiji,Carrie Welch,Jahangir Iqbal,M. Mahmood Hussain,Shunichi Takiguchi,Shizuya Yamashita,Issei Komuro,Daniel J. Rader,Alan R. Tall, CIRCULATION, LIPPINCOTT WILLIAMS & WILKINS, Vol. 128, No. 22, 2013/11
  • EZETIMIBE MARKEDLY REDUCED SERUM PLANT STEROLS IN JAPANESE PATIENTS WITH SITOSTEROLEMIA, M. Koseki,K. Tsubakio-Yamamoto,M. Yuasa-Kawase,H. Oku,J. C. Sandoval,D. Masuda,F. Matsuura,M. Nishida,M. Ishigami,K. Hirano,H. Hattori,I. Shimomura,M. Hori,S. Yamashita, ATHEROSCLEROSIS SUPPLEMENTS, ELSEVIER IRELAND LTD, Vol. 9, No. 1, p. 185-185, 2008/05
  • CHYLOMICRON REMNANTS ARE INCREASED IN CD36 DEFICIENCY AT POSTPRANDIAL STATE, D. Masuda,K. Hirano,H. Oku,J. Sandoval,M. Kawase,K. Yamamoto,M. Koseki,F. Matsuura,Y. Tochino,R. Kawase,M. Takada,Y. Yamashita,T. Kawamoto,M. Nishida,M. Ishigami,M. Hori,I. Shimomura,S. Yamashita, ATHEROSCLEROSIS SUPPLEMENTS, ELSEVIER IRELAND LTD, Vol. 9, No. 1, p. 27-28, 2008/05
  • ADIPONECTIN ENHANCES APOA-1-AND HDL-MEDIATED CHOLESTEROL EFFLUX FROM HUMAN MONOCYTE-DERIVED MACROPHAGES, K. Yamamoto,M. Koseki,F. Matsuura,H. Oku,J. Sandoval,M. Kawase,D. Masuda,M. Nishida,M. Ishigami,K. Hirano,S. Kihara,M. Hori,I. Shimomura,S. Yamashita, ATHEROSCLEROSIS SUPPLEMENTS, ELSEVIER IRELAND LTD, Vol. 9, No. 1, p. 52-52, 2008/05
  • ADIPONECTIN DEFICIENCY SUPPRESSES ABCA1 EXPRESSION AND APOA-I SYNTHESIS IN THE LIVER, F. Matsuura,H. Oku,M. Koseki,K. Yamamoto,J. C. Sandoval,M. Kawase,D. Masuda,T. Ohama,N. Maeda,M. Ishigami,M. Nishida,K. Hirano,S. Kihara,M. Hori,I. Shimomura,S. Yamashita, ATHEROSCLEROSIS SUPPLEMENTS, ELSEVIER IRELAND LTD, Vol. 9, No. 1, p. 24-24, 2008/05
  • Adiponectin enhanced ApoA-1-and HDL - mediated cellular cholesterol efflux from human monocyte-derived macrophages, Masahiro Koseki,Kazumi Tsubakio-Yamamoto,Fumihiko Matsuura,Hiroyuki Oku,Jose C. Sandoval,Miyako Yuasa-Kawase,Daisaku Masuda,Makoto Nishida,Masato Ishigami,Ken-Ichi Hirano,Shinji Kihara,Masatsugu Hori,Lichiro Shimomura,Shizuya Yamashita, CIRCULATION, LIPPINCOTT WILLIAMS & WILKINS, Vol. 116, No. 16, p. 160-161, 2007/10
  • Impaired efflux of cholesterol from aged cells and its molecular mechanism: A basis for age-related enhancement of atherosclerosis, Shizuya Yamashita,Ken-Ichi Hirano,Zhongan Zhang,Kosuke Tsukamoto,Daisaku Masuca,Masahiro Koseki,Fumihiko Matsuura,Masato Ishigami,Makoto Nishida,Lichiro Shimomura, GERIATRICS & GERONTOLOGY INTERNATIONAL, WILEY, Vol. 7, No. 3, p. 205-214, 2007/09
  • Increased lipid rafts and accelerated lipopolysaccharide-induced tumor necrosis factor alpha secretion in Abca1-deficient macrophages, M. Koseki,K. Hirano,D. Masuda,Z. Zhang,J. C. Sandoval,Y. Nakagawa-Toyama,H. Oku,C. Ikegami,M. Kawase,K. Yamamoto,Y. Ohno-Iwashita,F. Matsuura,M. Nishida,M. Ishigami,I. Shimomura,S. Yamashita, ATHEROSCLEROSIS SUPPLEMENTS, ELSEVIER IRELAND LTD, Vol. 8, No. 1, p. 82-83, 2007/06
  • Adiponectin protects against atherosclerosis by increasing cholesterol efflux from macrophages, K. Yamamoto,M. Koseki,R. Matsuura,C. Ikegami,H. Oku,S. J. Carlos,M. Kawase,D. Masuda,M. Nishida,M. Ishigami,K. Hirano,S. Kihara,I. Shimomura,S. Yamashita, ATHEROSCLEROSIS SUPPLEMENTS, ELSEVIER IRELAND LTD, Vol. 8, No. 1, p. 14-14, 2007/06
  • Postprandial hypertriglyceridemia in CD36 deficiency is caused by an accelerated lipoprotein synthesis in the small intestines, D. Masuda,K. Hirano,Y. Tochino,C. Ikegami,H. Oku,J. C. Sandoval,M. Kawase,K. Yamamoto,M. Koseki,F. Matsuura,M. Nishida,M. Ishigami,I. Shimomura,S. Yamashita, ATHEROSCLEROSIS SUPPLEMENTS, ELSEVIER IRELAND LTD, Vol. 8, No. 1, p. 27-27, 2007/06
  • Cd36 deficiency is associated with phenotypes of the metabolic syndrome and enhanced atherosclerotic cardiovascular diseases, M. Kawase,D. Masuda,K. Hirano,C. Ikegami,H. Oku,J. C. Sandoval,K. Yamamoto,M. Takada,Y. Ishikawa,M. Kirino,M. Koseki,F. Matsuura,M. Yamane,M. Nishida,M. Ishigami,I. Shimomura,S. Yamashita, ATHEROSCLEROSIS SUPPLEMENTS, ELSEVIER IRELAND LTD, Vol. 8, No. 1, p. 143-143, 2007/06
  • Adiponectin accelerates reverse cholesterol transport by increasing HDL assembly through upregulation of ABCA1 pathway and APOA-I synthesis in the liver, F. Matsuura,M. Koseki,Y. Oku,C. Ikegami,M. Kawase,K. Yamamoto,D. Masuda,M. Nishida,M. Ishigami,K. Hirano,S. Kihara,I. Shimomura,S. Yamashita, ATHEROSCLEROSIS SUPPLEMENTS, ELSEVIER IRELAND LTD, Vol. 8, No. 1, p. 19-20, 2007/06
  • CD36 deficiency is a monogenic form of the metabolic syndrome and its macrophages exhibit atherogenic profiles, Daisaku Masuda,Ken-ichi Hirano,Yoshihiro Tochino,Takahiro Kuwasako,Chiaki Ikegami,Masahiro Koseki,Yumiko Nakagawa-Toyama,Fumihiko Matsuura,Iichiro Shimomura,Masatsugu Hori,Shizuya Yamashita, JOURNAL OF HYPERTENSION, LIPPINCOTT WILLIAMS & WILKINS, Vol. 24, p. 162-162, 2006/12
  • Defective cholesterol efflux increased lipid rafts and enhanced lipopolysaccharide-induced cytokine release, M. Koseki,K. Hirano,D. Masuda,Z. Zhang,C. Ikegami,Y. Nakagawa-Toyama,Y. Ohno-Iwashita,I. Shimomura,M. Hori,S. Yamashita, ATHEROSCLEROSIS SUPPLEMENTS, ELSEVIER IRELAND LTD, Vol. 7, No. 3, p. 237-237, 2006/06
  • Probucol stabilizes hepatic scavenger receptor class B type I possibly through species-specific fashion, K. Hirano,C. Ikegami,K. Tsujii,Z. Zhang,F. Matsuura,Y. Nakagawa-Toyama,M. Koseki,D. Masuda,Y. Ueda,S. Yamashita, ATHEROSCLEROSIS SUPPLEMENTS, ELSEVIER IRELAND LTD, Vol. 7, No. 3, p. 575-575, 2006/06
  • Familial intrahepatic cholestasis 1 gene product, a novel contributor for cholesterol efflux, K. Hirano,Y. Nakagawa-Toyama,A. Ota,Z. Zhang,C. Ikegami,K. Tsukamoto,M. Koseki,D. Masuda,M. Nishida,S. Yamashita, ATHEROSCLEROSIS SUPPLEMENTS, ELSEVIER IRELAND LTD, Vol. 7, No. 3, p. 28-28, 2006/06
  • Pitavastatin improved postprandial hypertriglyceridemia caused by the accelerated intestinal lipid absorption in CD36 deficiency, D. Masuda,K. Hirano,Y. Tochino,T. Kuwasako,C. Ikegami,M. Koseki,Y. Nakagawa-Toyama,Z. Zhang,I. Shimomura,S. Yamasita, ATHEROSCLEROSIS SUPPLEMENTS, ELSEVIER IRELAND LTD, Vol. 7, No. 3, p. 510-510, 2006/06
  • SI-HDL、小腸由来高比重リポ蛋白の分析 抗動脈硬化作用への期待, Vol. 6回, p. 99-99, 2006/05
  • Increased chylomicron remnants (CR) in diabetic patients in relation to coronary heart disease (CHD) - analysis by a novel ELISA for apo B-48, S Yamashita,T Sugimoto,K Tsujii,M Koseki,D Masuda,Y Toyama,K Hirano,Y Uchida,N Sakai, JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, Vol. 39, No. 6, p. 1020-1021, 2005/12
  • Probucol enhances the expression of human hepatic scavenger receptor class B type I possibly through species-specific mechanism, K Hirano,C Ikegami,K Tsujii,M Koseki,D Masuda,Y Nakagawa-Toyama,Y Ueda,Shimomura, I,S Yamashita,M Hori, JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, Vol. 39, No. 6, p. 1005-1005, 2005/12
  • Accelerated intestinal absorption of dietary lipids causes postprandial hypertriglyceridemia in CD36 knockout mice, D Masuda,K Hirano,T Kuwasako,C Ikegami,M Koseki,Y Nakagawa-Toyama,ZY Zhang,Y Tochino,M Hori,S Yamashita, JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, Vol. 39, No. 6, p. 1003-1004, 2005/12
  • A novel cellular phenotype of macrophages with deficiency of atp-binding cassette transporter-A1 (ABCA1), M Koseki,K Hirano,D Masuda,ZY Zhang,C Ikegami,Y Nakagawa-Toyama,Y Shimada,Y Ohno-Iwashita,T Kobayashi,S Sato,Shimomura, I,M Hori,S Yamashita, JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, Vol. 39, No. 6, p. 1033-1033, 2005/12
  • Familial intrahepatic cholestasis 1 gene product, a novel contributor for cholesterol efflux in macrophages, KI Hirano,ZY Zhang,Y Nakagawa-Toyama,C Ikegami,K Tsukamoto,M Koseki,D Masuda,M Nishida,S Yamashita, CIRCULATION, LIPPINCOTT WILLIAMS & WILKINS, Vol. 112, No. 17, p. U227-U227, 2005/10
  • 小腸由来高比重リポ蛋白 新しい粥状動脈硬化治療標的として, Vol. 5回, p. 55-55, 2005/06
  • Novel ELISA for Apo B-48 revealed chylomicron remnants (CR) are accumulated in the serum of diabetic patients, predisposing them coronary heart disease (CHD), T Sugimoto,N Sakai,K Tsujii,M Koseki,T Hibuse,K Ohashi,T Nakamura,H Hiraoka,Y Uchida,S Yamashita, CIRCULATION, LIPPINCOTT WILLIAMS & WILKINS, Vol. 110, No. 17, p. 183-183, 2004/10
  • Vesicular acidification is required for ATP-bindig cassette transporter A1-mediated phospholipid and cholesterol efflux, A Matsuyama,N Sakai,M Koseki,T Ohama,K Hirano,H Hiraoka,S Yamashita, ATHEROSCLEROSIS SUPPLEMENTS, ELSEVIER SCI IRELAND LTD, Vol. 5, No. 1, p. 76-76, 2004/04
  • シトステロール血症の一例, Vol. 15, p. 85-88, 2004
  • Identification of a novel mutation in the ATP-binding cassette transporter G5 (ABCG5) in a Japanese patient with sitosterolemia, M Koseki,A Matsuyama,M Ishigami,K Hirano,N Sakai,H Hiraoka,T Nakamura,H Hattori,M Nagano,T Egashira,S Yamashita,Y Matsuzawa, ATHEROSCLEROSIS SUPPLEMENTS, ELSEVIER SCI IRELAND LTD, Vol. 4, No. 2, p. 138-138, 2003/09
  • Cloning and expression of a novel variant of scavenger receptor class B, type I (SRBI), SR-BIII, in human macrophages and atherosclerotic lesions, Z Zhang,Y Nakagawa-Toyama,K Tsujii,C Ikegami,M Nishida,K Tsukamoto,M Koseki,T Ohama,N Sakai,S Yamashita,Y Matsuzawa, ATHEROSCLEROSIS SUPPLEMENTS, ELSEVIER SCI IRELAND LTD, Vol. 4, No. 2, p. 68-68, 2003/09
  • Vesicular acidification is required for ATP-binding cassette transporter A1-mediated cholesterol efflux, A Matsuyama,N Sakai,M Koseki,Y Nishida,T Ohama,K Hirano,H Hiraoka,S Yamashita,Y Matsuzawa, ATHEROSCLEROSIS SUPPLEMENTS, ELSEVIER SCI IRELAND LTD, Vol. 4, No. 2, p. 135-135, 2003/09

Presentations

  • Progranulin deficiency leads to enhanced age-related cardiac hypertrophy through C1q-induced β-catenin activation(和訳中), 朱 穎こう,大濱 透,常 久洋,乾 洋勉,冠野 昂太郎,岡田 健志,小関 正博,西田 誠,坂田 泰史,山下 静也, 日本動脈硬化学会総会プログラム・抄録集, 2020/07
  • A dietary oxysterol, 7-ketocholesterol, exacerbates imiquimod-induced psoriasis-like dermatitis in steatohepatitis mice, Saga A,Koseki M,Kanno K,Chang J,Asaji M,Okada T,Inui H,Zhu Y,Ohama T,Nishida M,Yamashita S,Sakata Y, 2020/12/11
  • Pemafibrate Suppresses Liver Inflammation Caused by Atherogenic Diet and Improves Cardiac Function., Kanno K,Koseki M,Saga A,Chang J,Okada T,Inui H,Asaji M,Zhu Y,Ohama T,Nishida M,Yamashita S,Sakata Y, American Heart Association Scientific Sessions 2020, 2020/11/13
  • Targeted Exon Sequencing of Lipid-Related Genes in Patients with Clinically Diagnosed Familial Hypercholesterolemia, Okada T,Koseki M,Nishida M,Tanaka K,Inui H,Kanno K,Saga A,Ohama T,Kujiraoka T,Hattori H,Yamashita S,Sakata Y, American Heart Association Scientific Sessions 2020, 2020/11/13
  • Immunometabolic Disorder in Cardiovascular System and Liver Mediated by Long-term Exposure to Dietderived Oxidized Cholesterol, 7-Ketocholesterol, Koseki M,Kanno K,Saga A,Chang J,Inui H,Okada T,Ohama T,Nishida M,Kamada Y,Miyoshi E,Yamashita S,Sakata Y, 88th European Atherosclerosis Congress (EAS), 2020/10/04
  • Prevalence of Coronary Artery Disease and Achievement of Low-density Lipoprotein Cholesterol Management Targets in Familial Hypercholesterolemia Patients at Osaka University Hospital, Okada T,Koseki M,Inui H,Kanno K,Saga A,Ohama T,Nishida M,Yamashita S,Sakata Y, 88th European Atherosclerosis Congress (EAS), 2020/10/04
  • A Selective PPARα Modulator, Pemafibrate Reduced Hepatic Fibrosis and Cardiac Inflammation in Cholesterol-Dominant, Atherogenic-Diet Induced Steatohepatitis Model in STZ Induced Diabetic Mice., Chang J,Koseki M,Saga A,Kanno K,Okada T,Saito S,Kamada Y,Inui H,Asaji M,Zhu Y,Ohama T,Nishida M,Yamashita S,Sakata Y, The 4th JCS Council Forum on Basic CardioVascular Research, 2020/09/26
  • Pemafibrate Improves Steatohepatitis and Cardiac Function in Atherogenic-diet Mice Model, Kanno K,Koseki M,Saga A,Chang J,Okada T,Tanaka K,Inui H,Asaji M,Zhu Y,Ohama T,Nishida M,Yamashita S,Sakata Y, The 4th JCS Council Forum on Basic CardioVascular Research, 2020/09/26
  • イミキモド誘導乾癬モデルマウスにおける食事誘導脂肪肝炎の影響, 2020/08/28
  • The dietary 7-Ketocholesterol accelerated steatohepatitis in ob/ob mice by suppressing autophagy, 常久洋,Koseki M,嵯峨礼美, The 56th Annual Meeting of the Japan Society of Hepatology, 2020/08/28
  • 食餌誘導性肝線維化モデルにおけるペマフィブラートの肝臓、心臓への作用メカニズムの解明, 2020/08/28
  • 食事由来酸化ステロール蓄積のNAFLD、動脈硬化の進展における影響, 2020/08/28
  • 著名な低HDLコレステロール血症をきたす原発性脂質異常症の臨床的特徴と鑑別, 2020/08/07
  • The Role of Th1 and Th17 During Myocardial Infarction and Inhibitory Effect of Probucol on Th1 in SR-BI KO/ApoeR61h/h Mice, Inui H,Nishida M,Asaji M,Saga A,Kanno K,Okada T,Koseki M,Chang J,Zhu Y,Ohama T,Yamashita S,Sakata Y, The 84th Annual Scientific Meeting of the Japanese Circulation Society, 2020/07/27
  • A selective PPARα modulator, pemafibrate reduced hepatic cholesterol accumulation and inflammatory cell infiltration in atherogenic-diet induced steatohepatitis mouse model, 冠野昂太郎,小関正博,嵯峨礼美,常久洋,岡田健志,乾洋勉,朝治真澄,朱穎竑,大濱透,西田誠,山下静也,坂田泰史, The 84th Annual Scientific Meeting of the Japanese Circulation Society, 2020/07/27
  • The Current Status of Achievement of Low-density Lipoprotein Cholesterol Management Targets in Familial Hypercholesterolemia Patients in Osaka University Hospital, Okada T,Koseki M,Inui H,Kanno K,Chang J,Zhu Y,Saga A,Asaji M,Ohama T,Nishida M,Yamashita S,Sakata Y, The 84th Annual Scientific Meeting of the Japanese Circulation Society, 2020/07/27
  • Progranulin deficiency leads to enhanced age-related cardiac hypertrophy through Clq-induced β-catenin activation, 朱穎竑,大濵透,常久洋,乾洋勉,冠野昂太郎,岡田健志,小関正博,西田誠,坂田泰史,山下静也, The 52nd Annual Scientific Meeting the Japan Atherosclerosis Society, 2020/07/17
  • 動脈硬化惹起食誘導脂肪肝炎モデルにおける、ペマフィブラートの抗脂肪肝炎、抗心筋炎症作用の解明, 2020/07/17
  • NAFLD/NASH、動脈硬化進展における外因性酸化ステロール7-ketocholesterolの影響, 2020/07/17
  • 食餌誘発性脂肪肝炎マウスモデルにおいて7-ketocholesterolはイミキモド誘導乾癬様皮膚炎を増悪させる, 2020/07/17
  • The Dietary 7-ketocholesterol Accelerated Steatohepatitis in STZ Induced Diabetic Mice, Chang J,Koseki M,Saga A,Kanno K,Okada T,Saito S,Kamada Y,Inui H,Asaji M,Zhu Y,Ohama T,Nishida M,Yamashita S,Sakata Y, The 52nd Annual Scientific Meeting the Japan Atherosclerosis Society, 2020/07/17
  • Pemafibrate Improves Diet-induced Nonalcoholic Steatohepatitis Mediated by Decreased Intestinal Lipid Absorption in STZ Induced Diabetic Mice., Chang J,Koseki M,Saga A,Kanno K,Okada T,Saito S,Kamada Y,Inui H,Asaji M,Zhu Y,Ohama T,Nishida M,Yamashita S,Sakata Y, The 52nd Annual Scientific Meeting the Japan Atherosclerosis Society, 2020/07/17
  • Dietary oxysterol, 7-ketocholesterol accelerated steatohepatitis and atherosclerosis in Ldlr deficient mice model, 冠野昂太郎,小関正博,嵯峨礼美,常久洋,岡田健志,乾洋勉,朝治真澄,朱穎竑,大濵透,西田誠,山下静也,坂田泰史, The 52nd Annual Scientific Meeting the Japan Atherosclerosis Society, 2020/07/17
  • Pemafibrate improves hepatic fibrosis and cardiac inflammation in diet-induced steatohepatitis mice model, 冠野昂太郎,小関正博,嵯峨礼美,常久洋,岡田健志,乾洋勉,朝治真澄,朱穎竑,大濵透,西田誠,山下静也,坂田泰史, The 52nd Annual Scientific Meeting the Japan Atherosclerosis Society, 2020/07/17
  • Targeted Exon Sequencing of Lipid-Related Genes in Patients with Familial Hypercholesterolemia, Okada T,Koseki M,Nishida M,Inui H,Kanno K,Saga A,Ohama T,Kujiraoka T,Hattori H,Yamashita S,Sakata Y, The 52nd Annual Scientific Meeting the Japan Atherosclerosis Society, 2020/07/17
  • 食事由来7-ketocholesterolは、Ldl受容体欠損マウスにおいて、脂肪肝炎とアテローム性動脈硬化症を憎悪させる, 2020/05/14
  • 食餌由来7-ketocholesterolが糖尿病モデルラットの左室の収縮能、拡張能に及ぼす影響の検討, 2020/05/14
  • 食餌誘導性脂肪肝炎マウスモデルにおいて7-ketocholesterolは乾癬様皮膚炎を促進させる, 2020/05
  • The dietary 7-ketocholesterol accelerated steatohepatitis in ob/ob mice., Chang J,Koseki M,Saga A,Kanno K,Okada T,Saito S,Kamada Y,Inui H,Asaji M,Zhu Y,Ohama T,Nishida M,Yamashita S,Sakata Y, JCBL:62, 2020/05
  • 血清7-ketocholesterol濃度は7年後の肝機能異常を予測する, 2020/05
  • Development and Clinical Application of An Enzyme-Linked Immunosorbent Assay for Oxidized High Density Lipoprotein, Okada T,Ohama T,Saga A,Inui H,Kanno K,Koseki M,Nishida M,Sakata Y,Yamashita S, ACC.20 World Congress of Cardiology, 2020/03/28
  • Pemafibrate improves hepatic fibrosis and cardiac inflammation in atherogenic diet-induced steatohepatitis mice model, Koseki M, Keystone Symposia 2020, 2020/02/23
  • A selective PPARα modulator, pemafibrate reduced hepatic cholesterol content and inflammatory cell infiltration in atherogenic-diet induced steatohepatitis mouse model, Kanno K,Koseki M,Saga A,Chang J,Okada T,Inui H,Asaji M,Zhu Y,Ohama T,Nishida M,Yamashita S,Sakata Y, Keystone Symposia 2020, 2020/02/23
  • 当院通院中の肥満患者に対する運動習慣・体組成・心不全転帰の現状, 2020/02/15
  • 脂質の違いが引き起こすImmunometabolic Disorders-動脈硬化症とNAFLD/NASH-, 2020/01/11
  • 著名な高トリグリセリド血症をきたす原発性脂質異常症に対する食事療法と薬物療法, 2020/01/11
  • 著明な低HDLコレステロール血症をきたす原発性脂質異常症の臨床的特徴と鑑別, 2020/01/11
  • 当科脂質外来における家族性高コレステロール血症診療の現状, 2020/01/11
  • コレステリルエステル転送蛋白(CETP)欠損症リポ蛋白の動脈硬化惹起性に関する検討, 2020/01/11
  • The role of Th1 and Th17 During Acute phase of Myocardial Infarction in SR-BI KO/ApoeR61h/h mice, Inui H,Koseki M,Kanno K,Okada T,Sakata Y, Cardiovascular and Metabolic Week 2019(CVMW2019), 2019/12/14
  • Steatohepatitis mediated by the dietary cholesterol, 7-ketochlesterol accelerated atherosclerosis in Ldlr deficient mice, Kanno K,Koseki M,Jiuyang C,Inui H,Okada T,Sakata Y, Cardiovascular and Metabolic Week 2019(CVMW2019), 2019/12/14
  • Prevalence of Coronary Artery Disease and Achievement of Low-density Lipoprotein Cholesterol Management Targets in Familial Hypercholesterolemia Patients at Osaka University Hospital, Okada T,Koseki M,Inui H,Kanno K,Sakata Y, Cardiovascular and Metabolic Week 2019(CVMW2019), 2019/12/14
  • 7-ketocholesterolへの長期曝露により増悪する Immunometabolic Disorders -動脈硬化、脂肪肝炎、乾癬-, 2019/12/14
  • 著名な高LDL-C血症をきたした小児症例における食事指導の重要性, 2019/11/30
  • Pgrn Suppresses Pressure Overload-induced Cardiac Hypertrophy And Heart Failure In Mice Via Inhibiting The Activation Of β-catenin, Zhu Y,Ohama T,Inui H,Kanno K,Chang J,Okada T,Koseki M,Nishida M,Sakata Y,Yamashita S, AHA2019, 2019/11/16
  • The Predominance of Th1 and Th17 During the Process of Myocardial Infarction in Non-surgical MI model, SR-BI KO/ApoeR61h/h mice, Inui H,Nishida M,Asaji M,Saga A,Kanno K,Chang J,Zhu Y,Okada T,Ohama T,Koseki M,Yamashita S,Sakata Y, AHA2019, 2019/11/16
  • Pemafibrate regulate intestinal lipid absorption in diet-induced nonalcoholic steatohepatitis model in mice, 冠野 昂太郎,小関 正博,嵯峨 礼美,常 久洋,岡田 健志,乾 洋勉,朝治 真澄,朱 穎竑,大濱 透,西田 誠,山下 静也,坂田 泰史, AHA2019, 2019/11/16
  • The Current Status of the Treatment of FH Patients and the Achievement of LDL-C Target Value in the Lipid Clinic in Osaka University Hospital, Koseki M,Okada T,Kanno K,Ohama T,Nishida M,Yamashita S,Sakata Y, FH Global Summit, 2019/10/20
  • The dietary oxysterol accelerated steatohepatitis in ob/ob mice model, Chang J,Koseki M,Saga A,Kanno K,Okada T,Inui H,Asaji M,Zhu Y,Ohama T,Nishida M,Yamashita S,Sakata Y, The 3th JCS Council Forum on Basic CardioVascular Research, 2019/09/06
  • The Predominance of Th1 and Th17 During the Process of Myocardial Infarction in Non-surgical MI model, SR-BI KO/ApoeR61h/h mice, Inui H,Nishida M,Chang J,Zhu Y,Kanno K,Okada T,Ohama T,Koseki M,Yamashita S,Sakata Y, The 3th JCS Council Forum on Basic CardioVascular Research, 2019/09/06
  • The dietary oxidized cholesterol, 7-ketocholesterol, accelerated steatohepatitis and atherosclerosis in Ldlr deficient mice model, 冠野 昂太郎,小関 正博,嵯峨 礼美,常 久洋,岡田 健志,乾 洋勉,朝治 真澄,朱 穎竑,大濱 透,西田 誠,山下 静也,坂田 泰史, The 3th JCS Council Forum on Basic CardioVascular Research, 2019/09/06
  • Development of an Enzyme-Linked Immunosorbent Assay for Oxidized High Density Lipoprotein and Its Clinical Application for Cardiovascular Risk Assessment, Okada T,Yamashita S,Ohama T,Inui H,Kanno K,Koseki M,Nishida M,Sakata Y, The 4th JCS Council Forum on Basic CardioVascular Research, 2019/09/06
  • The effect of dietary oxysterol on steatohepatitis in diabetic mice model, Chang J,Koseki M,Saga A,Kanno K,Okada T,Asaji M,Zhu Y,Liu J,Matsuda H,Masuda D,Ohama T,Nishida M,Yamashita S,Sakata Y, The 51nd Annual Scientific Meeting the Japan Atherosclerosis Society, 2019/07/11
  • 当科脂質外来における家族性高コレステロール血症診療の現状, 2019/07/11
  • 新規食餌誘導性非アルコール性脂肪, 2019/07/11
  • 乾癬様皮膚炎マウスモデルにおける外因性酸化ステロールの影響の検討, 2019/07/11
  • 高コレステロール食誘発心筋梗塞モデルマウスにおけるT細胞の関与の検討, 2019/07/11
  • NAFLD/NASH進展における外因性酸化ステロールの影響の検討, 2019/07/11
  • Establishment of an Enzyme-linked Immunosorbent Assay for Oxidized High Density Lipoprotein and Its Clinical Significance for Cardiovascular Risk Assessment, Okada T,Ohama T,Inui H,Kanno K,Matsuda H,Koseki M,Nishida M,Sakata Y,Yamashita S, The 83th Annual Scientific Meeting of the Japanese Circulation Society, 2019/03/29
  • Oxidized cholesterol, 7-ketocholesterol, is an Important Risk Factor for the Development of Atherosclerosis, Koseki M, The 83th Annual Scientific Meeting of the Japanese Circulation Society, 2019/03/29
  • 家族性高コレステロール血症ホモ接合体に対する同種脂肪組織由来幹細胞移植法, 2019/03/21
  • Lipoprotein Particle Number Analysis of Detailed Subclasses by Gel Permeation HPLC, Okada T,Ohama T,Inui H,Kanno K,Matsuda H,Zhu Y,Masuda D,Koseki M,Nishida M,Sakata Y,Yamashita S, American Heart Association Annual Meeting 2018, 2018/11/10
  • Adipose Tissue-derived Cell Transplantation In A Homozygous Familial Hypercholesterolemia Patient, Koseki M,Saga A,Okada T,Kanno K,Asaji M,Tomita K,Osuga K,Ezoe S,Nishida M,Sakata Y,Yamashita S, American Heart Association Annual Meeting 2018, 2018/11/10
  • The Molecular Mechanism Underlying both Atherosclerosis and Non-alcoholic Steatohepatitis, Koseki M,Yamashita S,Sakata Y, The 66th Annual Scientific Session of the Japanese College of Cardiology, 2018/09/07
  • Lipoprotein Particle Number Analysis of Detailed Subclasses by Gel Permeation HPLC, Okada T,Ohama T,Okazaki M,Inui H,Kanno K,Matsuda H,Zhu Y,Masuda D,Koseki M,Nishida M,Sakata Y,Yamashita S, The 66th Annual Scientific Session of the Japanese College of Cardiology, 2018/09/07
  • 腸管上皮細胞のコレステロールトランスポータ―NPC1L1と核内受容体LXRを識る, 2018/07/12
  • 重症家族性高コレステロール血症に対する再生医療の臨床応用, 2018/07/12
  • NAFLD/NASHと動脈硬化症をつなぐ分子メカニズムは何か, 2018/07/12
  • 10年間の腹囲・BMIの変動と危険因子、生活習慣の関連, 2018/07/12
  • 冠動脈硬化と頸動脈分岐部狭窄を来した弾性繊維性仮性黄色腫の1例, 2018/07/12
  • 高コレステロール食誘発心筋梗塞モデルマウスにおける血球系細胞の関与, 2018/07/12
  • 家族性高コレステロール血症ホモ接合体に対する同種脂肪組織由来幹細胞移植療法の開発の現状, 2018/07/12
  • Rivaroxaban Improves the Progression of Ischemic Cardiomyopathy in a New Murine Model of Diet-Induced Myocardial Infarction, Liu J,Nishida M,Inui H,Zhu Y,Chang J,Kanno K,Matsuda H,Okada T,Sairyo M,Masuda D,Ohama T,Koseki M,Sakata Y,Yamashita S, The 50nd Annual Scientific Meeting the Japan Atherosclerosis Society, 2018/07/12
  • HDL Particle Number Analysis by Gel Permeation HPLC in Cholesteryl Ester Transfer Protein Deficiency, Okada T,Ohama T,Okazaki M,Inui H,Kanno K,Matsuda H,Zhu Y,Masuda D,Koseki M,Nishida M,Sakata Y,Yamashita S, The 50nd Annual Scientific Meeting the Japan Atherosclerosis Society, 2018/07/12
  • Atherogenicity in Tangier Disease - Literature-based Analysis and A Case Report-, Koseki M,Yamashita S,Sakata Y, Gordon Research Conference 2018 Lipoprotein Metabolism, 2018/06/10
  • Lipoprotein Particle Number Analysis of Detailed Subclasses by Gel Permeation HPLC, Okada T,Ohama T,Inui H,Kanno K,Matsuda H,Zhu Y,Masuda D,Koseki M,Nishida M,Sakata Y,Yamashita S, Gordon Research Conference 2018 Lipoprotein Metabolism, 2018/06/10
  • LXRalphaの新規調節機構:TTC39B阻害はLXRalphaのユビキチン化によるプロテアソーム分解を減弱させアテローム性動脈硬化症および非アルコール性脂肪性肝炎の両方を改善する, 2018/04/13
  • TTC39B Inhibition Attenuate Ubiquitination andProteasomal Degradation of LXR and Improve BothAtherosclerosis and Non-Alcoholic Steatohepatitis, Koseki M,Yamashita S,Sakata Y, The 82th Annual Scientific Meeting of the Japanese Circulation Society, 2018/03/23
  • トピック3 「FH awareness~いま、FH を再考する~」Atherogenicity through Known and Unknown Mechanisms in FH, 2018/03/23
  • Rivaroxaban Improves the Progression of Ischemic Cardiomyopathy in a New Murine Model of Diet-Induced Myocardial Infarction, Liu J,Nishida M,Inui H,Kanno K,Matsuda H,Okada T,Sairyo M,Masuda D,Ohama T,Koseki M,Sakata Y,Yamashita S, The 82th Annual Scientific Meeting of the Japanese Circulation Society, 2018/03/23
  • 重症家族性高コレステロール血症に対する再生医療・細胞治療の臨床応用, 2018/03/21
  • ”FH Awareness” -家族性高コレステロール血症(FH)と診断し、治療することの大切さ-, 2018/02/04
  • Both Atherosclerosis and Steatohepatitis were improved by TTC39B Inhibition via LXR Pathway, Koseki M,Sakata Y, The 1st JCS Council Forum on Basic CardioVascular Research, 2018/01/06

Social Activities

  • 家族性高コレステロール血症アフェレーシス患者会, 2015/09 -

Committee Memberships

  • 薬局・薬剤師活動委員会, 2020/12 - Present
  • 在宅・プライマリーケア委員会, 2020/12 - Present
  • 評議員, 2020/03 - Present
  • 動脈硬化診療・疫学委員会( ガイドライン委員会)委員, 2020/03 - Present
  • 原発性高脂血症研究班(タンジール病、アポリポタンパクA-1欠損症担当), 2019/04 - Present
  • 評議員, 2015/07 - Present
  • PCSK9 阻害薬適正使用声明文作成WG, 2017/11 - 2018/03

Other

  • 日本経済新聞:タンパク質阻害し肝炎改善 阪大、マウス実験で確認, 2016/07 - 2016/07
  • 朝日新聞:脂肪肝炎、特定のたんぱく質なくせば抑制 阪大チーム, 2016/07 - 2016/07
  • 読売新聞:脂肪肝炎治療につながる物質、阪大チームが特定, 2016/07 - 2016/07
  • NHKテレビ:脂肪肝炎、動脈硬化治療につながる物質の同定, 2016/07 - 2016/07
  • NHKテレビ:重症高コレステロール血症に対する再生医療, 2016/03 - 2016/03