Kobe University
- 1988
Kobe University Graduate School, Division of Medicine
- 1988
Kobe University School of Medicine
- 1982
Kobe University Faculty of Medicine
- 1982
Life sciences / Tumor biology /
Life sciences / Pathobiochemistry /
Life sciences / Cell biology /
Life sciences / Molecular biology /
Life sciences / Medical biochemistry /
日本生化学会奨励賞
1991
生化学会奨励賞
1991
Hypoxia-induced Wnt5a-secreting fibroblasts promote colon cancer progression.
Akikazu Harada, Yoshiaki Yasumizu, Takeshi Harada, Katsumi Fumoto, Akira Sato, Natsumi Maehara, Ryota Sada, Shinji Matsumoto, Takashi Nishina, Kiyoshi Takeda, Eiichi Morii, Hisako Kayama, Akira Kikuchi
Nature communications Vol. 16 No. 1 p. 3653-3653 2025/04/17 Research paper (scientific journal)
Intestinal Foxl1+ cell-derived CXCL12 maintains epithelial homeostasis by modulating cellular metabolism
Mayu Yagita-Sakamaki, Takayoshi Ito, Taiki Sakaguchi, Shuichi Shimma, Bo Li, Daisuke Okuzaki, Daisuke Motooka, Shota Nakamura, Koji Hase, Eiichiro Fukusaki, Akira Kikuchi, Takashi Nagasawa, Atsushi Kumanogoh, Kiyoshi Takeda, Hisako Kayama
International Immunology 2025/03/06 Research paper (scientific journal)
Hypoxia drives the formation of lung micropapillary adenocarcinoma-like structure through hypoxia-inducible factor-1α
Daisuke Umeda, Akikazu Harada, Daisuke Motooka, Shinichiro Tahara, Masako Kurashige, Kansuke Kido, Tsuyoshi Takashima, Hiroki Kiyokawa, Koto Ukon, Takahiro Matsui, Shinji Matsumoto, Yasushi Shintani, Daisuke Okuzaki, Akira Kikuchi, Satoshi Nojima, Eiichi Morii
Scientific Reports Vol. 14 No. 1 2024/12/30 Research paper (scientific journal)
Publisher: Springer Science and Business Media LLC
肝細胞癌におけるDKK1-CKAP4シグナル軸の予後因子としての機能解析および新規治療標的としての可能性の検討(An analysis of DKK1-CKAP4 signaling as a prognostic factor and potential therapeutic target of hepatocellular carcinoma)
佐田 遼太, 井口 浩輔, 松本 真司, 全 陽, 秋田 真之, 権 英寿, 福本 巧, 菊池 章
日本癌学会総会記事 Vol. 83回 p. J-1021 2024/09
Publisher: (一社)日本癌学会Newly developed humanized anti-CKAP4 antibody suppresses pancreatic cancer growth by inhibiting DKK1-CKAP4 signaling.
Ryota Sada, Hideki Yamamoto, Shinji Matsumoto, Akikazu Harada, Akira Kikuchi
Cancer science 2024/08/08 Research paper (scientific journal)
Role of Wnt5b-Ror1 signaling in the proliferation of pancreatic ductal adenocarcinoma cells.
Natsuko Yamauchi, Mako Otsuka, Tomohiro Ishikawa, Yoshihiro Kakeji, Akira Kikuchi, Atsuhiro Masuda, Yuzo Kodama, Yasuhiro Minami, Koki Kamizaki
Genes to cells : devoted to molecular & cellular mechanisms 2024/03/26 Research paper (scientific journal)
Wnt/β-catenin signaling pathway in liver biology and tumorigenesis.
Shinji Matsumoto, Akira Kikuchi
In vitro cellular & developmental biology. Animal 2024/02/20 Research paper (scientific journal)
DKK1受容体CKAP4の細胞内輸送制御の解析
山本 英樹, 佐田 遼太, 菊池 章
日本生化学会大会プログラム・講演要旨集 Vol. 96回 p. [2P-269] 2023/10
Publisher: (公社)日本生化学会上皮組織の形態形成メカニズム-接着、極性、病態の観点から- 腺組織におけるWntシグナル誘導性の扁平円柱前駆細胞の同定と組織構築における役割
松本 真司, 原田 武志, 菊池 章
日本生化学会大会プログラム・講演要旨集 Vol. 96回 p. [2S06m-05] 2023/10
Publisher: (公社)日本生化学会Gene regulation program for proliferation and differentiation in Wnt signal-activated liver and colon cancer
菊池 章, 松本 真司, 原田 昭和
日本癌学会総会記事 Vol. 82回 p. 382-382 2023/09 Research paper (scientific journal)
Publisher: (一社)日本癌学会GREB1 isoform 4 is specifically transcribed by MITF and required for melanoma proliferation.
Koei Shinzawa, Shinji Matsumoto, Ryota Sada, Akikazu Harada, Kaori Saitoh, Keiko Kato, Satsuki Ikeda, Akiyoshi Hirayama, Kazunori Yokoi, Atsushi Tanemura, Keisuke Nimura, Masahito Ikawa, Tomoyoshi Soga, Akira Kikuchi
Oncogene Vol. 42 No. 42 p. 3142-3156 2023/09/01 Research paper (scientific journal)
The Helicobacter pylori CagA oncoprotein disrupts Wnt/PCP signaling and promotes hyperproliferation of pyloric gland base cells.
Atsushi Takahashi-Kanemitsu, Mengxue Lu, Christopher Takaya Knight, Takayoshi Yamamoto, Takuo Hayashi, Yusuke Mii, Takuya Ooki, Ippei Kikuchi, Akira Kikuchi, Nick Barker, Etsuo A Susaki, Masanori Taira, Masanori Hatakeyama
Science signaling Vol. 16 No. 794 2023/07/18 Research paper (scientific journal)
Wnt Signaling Stimulates Cooperation between GREB1 and HNF4α to Promote Proliferation in Hepatocellular Carcinoma.
Shinji Matsumoto, Akikazu Harada, Minami Seta, Masayuki Akita, Hidetoshi Gon, Takumi Fukumoto, Akira Kikuchi
Cancer research Vol. 83 No. 14 p. 2312-2327 2023/07/14 Research paper (scientific journal)
Wnt5a-YAP signaling axis mediates mechanotransduction in cardiac myocytes and contributes to contractile dysfunction induced by pressure overload
Hiroshi Kishimoto, Masayoshi Iwasaki, Kensaku Wada, Keita Horitani, Osamu Tsukamoto, Kenta Kamikubo, Seitaro Nomura, Shinji Matsumoto, Takeshi Harada, Daisuke Motooka, Daisuke Okuzaki, Seiji Takashima, Issei Komuro, Akira Kikuchi, Ichiro Shiojima
iScience p. 107146-107146 2023/06 Research paper (scientific journal)
Publisher: Elsevier BV
CKAP4 is a potential exosomal biomarker and therapeutic target for lung cancer
Akihiro Nagoya, Ryota Sada, Hirokazu Kimura, Hideki Yamamoto, Koichi Morishita, Eiji Miyoshi, Eiichi Morii, Yasushi Shintani, Akira Kikuchi
Translational Lung Cancer Research Vol. 12 No. 3 p. 408-426 2023/03 Research paper (scientific journal)
Publisher: AME Publishing Company
Wnt 2022 EMBO | the Company of Biologists workshop and Yamada conference.
Akira Kikuchi, Junichi Takagi, Shinji Takada, Tohru Ishitani, Yasuhiro Minami
Genes to cells : devoted to molecular & cellular mechanisms 2023/02/27 Research paper (scientific journal)
The DKK1-CKAP4 signal axis promotes hepatocellular carcinoma aggressiveness.
Kosuke Iguchi, Ryota Sada, Shinji Matsumoto, Hirokazu Kimura, Yoh Zen, Masayuki Akita, Hidetoshi Gon, Takumi Fukumoto, Akira Kikuchi
Cancer science Vol. 114 No. 5 p. 2063-2077 2023/01/31 Research paper (scientific journal)
Reflections on the 50-year history of the Federation of Asian and Oceanian Biochemists and Molecular Biologists (FAOBMB).
Phillip Nagley, Jisnuson Svasti, Akira Kikuchi
IUBMB life Vol. 74 No. 12 p. 1126-1168 2022/12 Research paper (scientific journal)
A special issue of IUBMB Life celebrating the 50th anniversary of FAOBMB (1972-2022).
Akira Kikuchi, Zengyi Chang, Paul A Gleeson
IUBMB life Vol. 74 No. 12 p. 1124-1125 2022/12 Research paper (scientific journal)
新規DKK1受容体CKPA4の細胞内輸送制御
山本 英樹, 佐田 遼太, 菊池 章
日本生化学会大会プログラム・講演要旨集 Vol. 95回 p. 1P-172 2022/11
Publisher: (公社)日本生化学会肺がんにおけるDKK1-CKAP4シグナルと抗CKAP4抗体の有用性
名越 章裕, 佐田 遼太, 木村 公一, 山本 英樹, 新谷 康, 菊池 章
日本癌治療学会学術集会抄録集 Vol. 60回 p. P55-1 2022/10
Publisher: (一社)日本癌治療学会GREB1を介する新規がんシグナル経路は分子標的となる。(The novel cancer sigamling pathway through GREB1 represents a terapeutic target)
菊池 章, 松本 真司, 新澤 康英, 佐田 遼太, 原田 昭和
日本癌学会総会記事 Vol. 81回 p. J-2032 2022/09
Publisher: (一社)日本癌学会悪性黒色腫におけるMITF依存的なGREB1アイソフォーム4の発現は、ピリミジン合成を介して細胞増殖を促進する(MITF-dependent GREB1 isoform 4 expression stimulates melanoma proliferation through pyrimidine synthesis)
新澤 康英, 松本 真司, 佐田 遼太, 原田 昭和, 種村 篤, 二村 圭祐, 伊川 正人, 曽我 朋義, 菊池 章
日本癌学会総会記事 Vol. 81回 p. P-2055 2022/09
Publisher: (一社)日本癌学会GREB1を介する新規がんシグナル経路は分子標的となる。(The novel cancer sigamling pathway through GREB1 represents a terapeutic target)
菊池 章, 松本 真司, 新澤 康英, 佐田 遼太, 原田 昭和
日本癌学会総会記事 Vol. 81回 p. J-2032 2022/09 Research paper (scientific journal)
Publisher: (一社)日本癌学会悪性黒色腫におけるMITF依存的なGREB1アイソフォーム4の発現は、ピリミジン合成を介して細胞増殖を促進する(MITF-dependent GREB1 isoform 4 expression stimulates melanoma proliferation through pyrimidine synthesis)
新澤 康英, 松本 真司, 佐田 遼太, 原田 昭和, 種村 篤, 二村 圭祐, 伊川 正人, 曽我 朋義, 菊池 章
日本癌学会総会記事 Vol. 81回 p. P-2055 2022/09 Research paper (scientific journal)
Publisher: (一社)日本癌学会Dickkopf signaling, beyond Wnt-mediated biology.
Akira Kikuchi, Shinji Matsumoto, Ryota Sada
Seminars in cell & developmental biology Vol. 125 p. 55-65 2021/11/17 Research paper (scientific journal)
RAF1-MEK/ERK pathway-dependent ARL4C expression promotes ameloblastoma cell proliferation and osteoclast formation.
Shinsuke Fujii, Takuma Ishibashi, Megumi Kokura, Tatsufumi Fujimoto, Shinji Matsumoto, Satsuki Shidara, Kari J Kurppa, Judith Pape, Javier Caton, Peter R Morgan, Kristiina Heikinheimo, Akira Kikuchi, Eijiro Jimi, Tamotsu Kiyoshima
The Journal of pathology Vol. 256 No. 1 p. 119-133 2021/10/08 Research paper (scientific journal)
Localization of KRAS downstream target ARL4C to invasive pseudopods accelerates pancreatic cancer cell invasion
Akikazu Harada, Shinji Matsumoto, Yoshiaki Yasumizu, Toshiyuki Akama, Hidetoshi Eguchi, Akira Kikuchi
eLife Vol. 10 2021/09/30 Research paper (scientific journal)
Publisher: eLife Sciences Publications, Ltd
Localization of KRAS downstream target ARL4C to invasive pseudopods accelerates pancreatic cancer cell invasion.
Akikazu Harada, Shinji Matsumoto, Yoshiaki Yasumizu, Toshiyuki Akama, Hidetoshi Eguchi, Akira Kikuchi
eLife Vol. 10 2021/09/30 Research paper (scientific journal)
Proposing a molecular classification associated with hypercoagulation in ovarian clear cell carcinoma
Ryo Tamura, Kosuke Yoshihara, Koji Matsuo, Nozomi Yachida, Ai Miyoshi, Kotaro Takahashi, Kentaro Sugino, Manako Yamaguchi, Yutaro Mori, Kazuaki Suda, Tatsuya Ishiguro, Shujiro Okuda, Teiichi Motoyama, Hirofumi Nakaoka, Akira Kikuchi, Yutaka Ueda, Ituro Inoue, Takayuki Enomoto
Gynecologic Oncology Vol. 163 No. 2 p. 327-333 2021/08 Research paper (scientific journal)
Publisher: Elsevier BV
Stage-dependent function of Wnt5a during male external genitalia development.
Mellissa C Alcantara, Kentaro Suzuki, Alvin R Acebedo, Yuki Sakamoto, Michiru Nishita, Yasuhiro Minami, Akira Kikuchi, Gen Yamada
Congenital anomalies 2021/07/13 Research paper (scientific journal)
Suv4-20h2 protects against influenza virus infection by suppression of chromatin loop formation.
Masami Shiimori, Yu Ichida, Ryota Nukiwa, Toshie Sakuma, Haruka Abe, Rei Kajitani, Yuji Fujino, Akira Kikuchi, Takeshi Kawamura, Tatsuhiko Kodama, Shinichi Toyooka, Katsuhiko Shirahige, Gunnar Schotta, Keiji Kuba, Takehiko Itoh, Yumiko Imai
iScience Vol. 24 No. 6 p. 102660-102660 2021/06/25 Research paper (scientific journal)
TAZ inhibits acinar cell differentiation but promotes immature ductal cell proliferation in adult mouse salivary glands.
Yosuke Miyachi, Miki Nishio, Junji Otani, Shinji Matsumoto, Akira Kikuchi, Tak Wah Mak, Tomohiko Maehama, Akira Suzuki
Genes to cells : devoted to molecular & cellular mechanisms Vol. 26 No. 9 p. 714-726 2021/06/17 Research paper (scientific journal)
The Dickkopf1 and FOXM1 positive feedback loop promotes tumor growth in pancreatic and esophageal cancers.
Hirokazu Kimura, Ryota Sada, Naoki Takada, Akikazu Harada, Yuichiro Doki, Hidetoshi Eguchi, Hideki Yamamoto, Akira Kikuchi
Oncogene Vol. 40 No. 26 p. 4486-4502 2021/06/11 Research paper (scientific journal)
Lymphadenectomy issues in endometrial cancer.
Yosuke Konno, Hiroshi Asano, Ayumi Shikama, Daisuke Aoki, Michihiro Tanikawa, Akinori Oki, Koji Horie, Akira Mitsuhashi, Akira Kikuchi, Hideki Tokunaga, Yasuhisa Terao, Toyomi Satoh, Kimio Ushijima, Mitsuya Ishikawa, Nobuo Yaegashi, Hidemichi Watari
Journal of gynecologic oncology Vol. 32 No. 2 2021/03 Research paper (scientific journal)
YAP signaling induces PIEZO1 to promote oral squamous cell carcinoma cell proliferation.
Kana Hasegawa, Shinsuke Fujii, Shinji Matsumoto, Yudai Tajiri, Akira Kikuchi, Tamotsu Kiyoshima
The Journal of pathology Vol. 253 No. 1 p. 80-93 2021/01 Research paper (scientific journal)
Palmitoylated CKAP4 regulates mitochondrial functions through an interaction with VDAC2 at ER-mitochondria contact sites.
Takeshi Harada, Ryota Sada, Yoshito Osugi, Shinji Matsumoto, Tomoki Matsuda, Mitsuko Hayashi-Nishino, Takeharu Nagai, Akihiro Harada, Akira Kikuchi
Journal of cell science Vol. 133 No. 21 2020/11/10 Research paper (scientific journal)
上皮形態形成研究を基盤とした新規抗がん剤開発
菊池 章, 松本 真司, 佐田 僚太
膵臓 Vol. 35 No. 3 p. A90-A90 2020/07
Publisher: (一社)日本膵臓学会XCL1 expression correlates with CD8-positive T cells infiltration and PD-L1 expression in squamous cell carcinoma arising from mature cystic teratoma of the ovary.
Ryo Tamura, Kosuke Yoshihara, Hirofumi Nakaoka, Nozomi Yachida, Manako Yamaguchi, Kazuaki Suda, Tatsuya Ishiguro, Koji Nishino, Hiroshi Ichikawa, Keiichi Homma, Akira Kikuchi, Yutaka Ueda, Yuji Takei, Hiroyuki Fujiwara, Teiichi Motoyama, Shujiro Okuda, Toshifumi Wakai, Ituro Inoue, Takayuki Enomoto
Oncogene Vol. 39 No. 17 p. 3541-3554 2020/04 Research paper (scientific journal)
ARL4C is associated with initiation and progression of lung adenocarcinoma and represents a therapeutic target.
Kenji Kimura, Shinji Matsumoto, Takeshi Harada, Eiichi Morii, Izumi Nagatomo, Yasushi Shintani, Akira Kikuchi
Cancer science Vol. 111 No. 3 p. 951-961 2020/03 Research paper (scientific journal)
Mark1 regulates distal airspace expansion through type I pneumocyte flattening in lung development.
Katsumi Fumoto, Hisako Takigawa-Imamura, Kenta Sumiyama, Shige H Yoshimura, Natsumi Maehara, Akira Kikuchi
Journal of cell science Vol. 132 No. 24 2019/12/13 Research paper (scientific journal)
Changes in the Clinicopathological Demographics of Vulvar Cancer in Japan: Increasing Oldest-Old, Stage Shifting, and Decreasing Cohort-Level Survival †.
Shin Nishio, Koji Matsuo, Takeo Shibata, Satoshi Yamaguchi, Hiroyuki Kanao, Kazuhiro Takehara, Nobuhiro Kado, Akiko Tozawa, Hideki Tokunaga, Tatsuya Matsunaga, Hisamori Kato, Koji Horie, Akira Kikuchi, Takayuki Enomoto, Mikio Mikami
Journal of clinical medicine Vol. 8 No. 12 2019/11/29 Research paper (scientific journal)
Dynamic palmitoylation controls the microdomain localization of the DKK1 receptors CKAP4 and LRP6.
Ryota Sada, Hirokazu Kimura, Yuko Fukata, Masaki Fukata, Hideki Yamamoto, Akira Kikuchi
Science signaling Vol. 12 No. 608 2019/11/19 Research paper (scientific journal)
DKK1受容体であるCKAP4とLRP6の動的パルミチン酸化は細胞膜マイクロドメイン局在を誘導しDKK1シグナルを制御する(Dynamic palmitoylation determines membrane microdomain localization of two DKK1 receptors CKAP4 and LRP6, and regulates DKK1 signaling)
山本 英樹, 佐田 遼太, 木村 公一, 菊池 章
日本生化学会大会プログラム・講演要旨集 Vol. 92回 p. [3P-198] 2019/09
Publisher: (公社)日本生化学会DKK1新規受容体CKAP4は膵臓癌由来のエクソソームのバイオマーカーとがん治療の分子標的になる(CKAP4, a DKK1 receptor, is a biomarker in exosomes derived from pancreatic cancer and a molecular target for therapy)
山本 英樹, 木村 公一, 菊池 章
日本癌学会総会記事 Vol. 78回 p. P-2085 2019/09
Publisher: 日本癌学会GREB1 induced by Wnt signaling promotes development of hepatoblastoma by suppressing TGFβ signaling.
Shinji Matsumoto, Taku Yamamichi, Koei Shinzawa, Yuuya Kasahara, Satoshi Nojima, Takahiro Kodama, Satoshi Obika, Tetsuo Takehara, Eiichi Morii, Hiroomi Okuyama, Akira Kikuchi
Nature communications Vol. 10 No. 1 p. 3882-3882 2019/08/28 Research paper (scientific journal)
CKAP4 Regulates Cell Migration via the Interaction with and Recycling of Integrin.
Yoshihito Osugi, Katsumi Fumoto, Akira Kikuchi
Molecular and cellular biology Vol. 39 No. 16 2019/08/15 Research paper (scientific journal)
Arl4cを標的とした新規肺腺癌治療薬の開発
木村 賢二, 新谷 康, 松本 真司, 金沢 豪, 大和 寛幸, 久能 英法, 福井 絵里子, 神崎 隆, 狩野 孝, 大瀬 尚子, 舟木 壮一郎, 南 正人, 菊池 章
日本呼吸器外科学会雑誌 Vol. 33 No. 3 p. RO10-3 2019/04
Publisher: (NPO)日本呼吸器外科学会Correction to: Future projection of cancer patients with cardiovascular disease in Japan by the year 2039: a pilot study.
Okura Y, Takayama T, Ozaki K, Tanaka H, Kikuchi A, Saito T, Tanigawa T, Takii Y, Seki H, Takenouchi T, Chou T, Sato N, Tanabe N, Minamino T
International journal of clinical oncology Vol. 24 No. 8 p. 995-995 2019/04 Research paper (scientific journal)
CKAP4, a DKK1 Receptor, Is a Biomarker in Exosomes Derived from Pancreatic Cancer and a Molecular Target for Therapy.
Hirokazu Kimura, Hideki Yamamoto, Takeshi Harada, Katsumi Fumoto, Yoshihito Osugi, Ryota Sada, Natsumi Maehara, Hayato Hikita, Soichiro Mori, Hidetoshi Eguchi, Masahito Ikawa, Tetsuo Takehara, Akira Kikuchi
Clinical cancer research : an official journal of the American Association for Cancer Research Vol. 25 No. 6 p. 1936-1947 2019/03/15 Research paper (scientific journal)
Wnt/β-catenin signaling, which is activated in odontomas, reduces Sema3A expression to regulate odontogenic epithelial cell proliferation and tooth germ development.
Shinsuke Fujii, Kengo Nagata, Shinji Matsumoto, Ken-Ichi Kohashi, Akira Kikuchi, Yoshinao Oda, Tamotsu Kiyoshima, Naohisa Wada
Scientific reports Vol. 9 No. 1 p. 4257-4257 2019/03/12 Research paper (scientific journal)
Future projection of cancer patients with cardiovascular disease in Japan by the year 2039: a pilot study.
Okura Y, Takayama T, Ozaki K, Tanaka H, Kikuchi A, Saito T, Tanigawa T, Takii Y, Seki H, Takenouchi T, Chou T, Sato N, Tanabe N, Minamino T
International journal of clinical oncology Vol. 24 No. 8 p. 983-994 2019/03 Research paper (scientific journal)
Chemically Modified Antisense Oligonucleotide Against ARL4C Inhibits Primary and Metastatic Liver Tumor Growth.
Takeshi Harada, Shinji Matsumoto, Suguru Hirota, Hirokazu Kimura, Shinsuke Fujii, Yuuya Kasahara, Hidetoshi Gon, Toshihiko Yoshida, Tomoo Itoh, Naotsugu Haraguchi, Tsunekazu Mizushima, Takehiro Noda, Hidetoshi Eguchi, Satoshi Nojima, Eiichi Morii, Takumi Fukumoto, Satoshi Obika, Akira Kikuchi
Molecular cancer therapeutics Vol. 18 No. 3 p. 602-612 2019/03 Research paper (scientific journal)
[Canonical Wnt signaling pathway and current issues.]
Fumoto K, Kikuchi A
Clinical calcium Vol. 29 No. 3 p. 283-289 2019
Wnt signaling pathways in cancers: key targets and implications in cancer therapy
Shinji Matsumoto, Akira Kikuchi
Leading Author's Vol. 7 2018/12
p63-Dependent Dickkopf3 Expression Promotes Esophageal Cancer Cell Proliferation via CKAP4.
Chihiro Kajiwara, Katsumi Fumoto, Hirokazu Kimura, Satoshi Nojima, Keita Asano, Kazuki Odagiri, Makoto Yamasaki, Hayato Hikita, Tetsuo Takehara, Yuichiro Doki, Eiichi Morii, Akira Kikuchi
Cancer research Vol. 78 No. 21 p. 6107-6120 2018/11/01 Research paper (scientific journal)
現代の生命科学研究の潮流を探る-ChIP-seqから組織器官培養、遺伝子改変マウス、タンパク質構造解析まで- 唾液腺におけるWntシグナル依存性新規前駆細胞の同定と機能解析
松本 真司, 廣田 傑, 菊池 章
Journal of Oral Biosciences Supplement Vol. 2018 p. 119-119 2018/09
Publisher: (一社)歯科基礎医学会肺癌発癌過程におけるArl4cの機能解析(Analysis of Arl4c during the carcinogenesis of lung adenocarcinoma)
木村 賢二, 松本 真司, 新谷 康, 菊池 章
日本癌学会総会記事 Vol. 77回 p. 2239-2239 2018/09
Publisher: (一社)日本癌学会Arl4cとIQGAP1の相互作用による膵がん細胞の増殖制御機構
赤間 俊之, 松本 真司, 原田 昭和, 庄嶋 健作, 菊池 章
日本生化学会大会プログラム・講演要旨集 Vol. 91回 p. [1T12m-226)] 2018/09
Publisher: (公社)日本生化学会小胞体-ミトコンドリア連携ゾーンにおけるII型膜タンパク質CKAP4の機能解析
原田 武志, 大杉 祥仁, 松本 真司, 菊池 章
日本生化学会大会プログラム・講演要旨集 Vol. 91回 p. [1P-178] 2018/09
Publisher: (公社)日本生化学会Map7/7D1 and Dvl form a feedback loop that facilitates microtubule remodeling and Wnt5a signaling.
Koji Kikuchi, Akira Nakamura, Masaki Arata, Dongbo Shi, Mami Nakagawa, Tsubasa Tanaka, Tadashi Uemura, Toshihiko Fujimori, Akira Kikuchi, Akiyoshi Uezu, Yasuhisa Sakamoto, Hiroyuki Nakanishi
EMBO reports Vol. 19 No. 7 2018/07 Research paper (scientific journal)
Activation of the Dickkopf1-CKAP4 pathway is associated with poor prognosis of esophageal cancer and anti-CKAP4 antibody may be a new therapeutic drug.
Naoki Shinno, Hirokazu Kimura, Ryota Sada, Shuji Takiguchi, Masaki Mori, Katsumi Fumoto, Yuichiro Doki, Akira Kikuchi
Oncogene Vol. 37 No. 26 p. 3471-3484 2018/06 Research paper (scientific journal)
Wnt5a-induced cell migration is associated with the aggressiveness of estrogen receptor-positive breast cancer.
Yoshie Kobayashi, Takayuki Kadoya, Ai Amioka, Hideaki Hanaki, Shinsuke Sasada, Norio Masumoto, Hideki Yamamoto, Koji Arihiro, Akira Kikuchi, Morihito Okada
Oncotarget Vol. 9 No. 30 p. 20979-20992 2018/04/20 Research paper (scientific journal)
LDLによるLRP6のエンドサイトーシス経路とNPC1L1の細胞内局在の制御機構
山本 英樹, 梅田 大介, 松本 真司, 菊池 章
生命科学系学会合同年次大会 Vol. 2017年度 p. [1P-0469] 2017/12
Publisher: 生命科学系学会合同年次大会運営事務局The Dickkopf1-cytoskeleton-associated protein 4 axis creates a novel signalling pathway and may represent a molecular target for cancer therapy.
Akira Kikuchi, Katsumi Fumoto, Hirokazu Kimura
British journal of pharmacology Vol. 174 No. 24 p. 4651-4665 2017/12 Research paper (scientific journal)
Apical secretion of Wnt1 in polarized epithelial cells is regulated by exocyst-mediated trafficking.
Hideki Yamamoto, Akira Sato, Akira Kikuchi
Journal of biochemistry Vol. 162 No. 5 p. 317-326 2017/11/01 Research paper (scientific journal)
LDL switches the LRP6 internalization route from flotillin dependent to clathrin dependent in hepatic cells.
Hideki Yamamoto, Daisuke Umeda, Shinji Matsumoto, Akira Kikuchi
Journal of cell science Vol. 130 No. 20 p. 3542-3556 2017/10/15 Research paper (scientific journal)
Two cases of endometrial cancer arising from adenomyosis during aromatase inhibitors therapy after mastectomy
Toru Yanase, Akira Kikuchi, Motoi Sasagawa, Shigeru Honma
JOURNAL OF OBSTETRICS AND GYNAECOLOGY Vol. 37 No. 7 p. 952-954 2017/10 Research paper (scientific journal)
細胞増殖制御因子XはWntシグナル依存的に肝芽腫の腫瘍形成を制御する
山道 拓, 松本 真司, 菊池 章
日本癌学会総会記事 Vol. 76回 p. P-2028 2017/09
Publisher: (一社)日本癌学会The role of para-aortic lymphadenectomy in stage IIIC endometrial cancer: A single-institute study
Akira Kikuchi, Toru Yanase, Motoi Sasagawa, Shigeru Honma
JOURNAL OF OBSTETRICS AND GYNAECOLOGY Vol. 37 No. 4 p. 510-513 2017/05 Research paper (scientific journal)
ヒト肺腺癌および肺扁平上皮癌におけるArl4cの発現はがん形成を促進する
藤井 慎介, 松本 真司, 清島 保, 菊池 章
日本病理学会会誌 Vol. 106 No. 1 p. 294-294 2017/03
Publisher: (一社)日本病理学会Wnt5b-associated exosomes promote cancer cell migration and proliferation
Takeshi Harada, Hideki Yamamoto, Shosei Kishida, Michiko Kishida, Chihiro Awada, Toshifumi Takao, Akira Kikuchi
CANCER SCIENCE Vol. 108 No. 1 p. 42-52 2017/01 Research paper (scientific journal)
Modulation of apical constriction by Wnt signaling is required for lung epithelial shape transition.
Katsumi Fumoto, Hisako Takigawa-Imamura, Kenta Sumiyama, Tomoyuki Kaneiwa, Akira Kikuchi
Development (Cambridge, England) Vol. 144 No. 1 p. 151-162 2017/01/01 Research paper (scientific journal)
Arl4c is a key regulator of tubulogenesis and tumourigenesis as a target gene of Wnt-β-catenin and growth factor-Ras signalling.
Shinji Matsumoto, Shinsuke Fujii, Akira Kikuchi
Journal of biochemistry Vol. 161 No. 1 p. 27-35 2017/01 Research paper (scientific journal)
Epigenetic upregulation of ARL4C, due to DNA hypomethylation in the 3'-untranslated region, promotes tumorigenesis of lung squamous cell carcinoma.
Shinsuke Fujii, Keiko Shinjo, Shinji Matsumoto, Takeshi Harada, Satoshi Nojima, Sunao Sato, Yu Usami, Satoru Toyosawa, Eiichi Morii, Yutaka Kondo, Akira Kikuchi
Oncotarget Vol. 7 No. 49 p. 81571-81587 2016/12/06 Research paper (scientific journal)
ヒト大腸癌、肺腺癌および肺扁平上皮癌におけるArl4cの発現および機能解析
藤井 慎介, 松本 真司, 菊池 章
日本癌学会総会記事 Vol. 75回 p. J-2007 2016/10
Publisher: (一社)日本癌学会Wntシグナルは細胞増殖制御因子Xの発現を誘導し、尿管芽上皮の管腔形成と肝芽腫の腫瘍形成に関与する
山道 拓, 松本 真司, 菊池 章
日本癌学会総会記事 Vol. 75回 p. J-2010 2016/10
Publisher: (一社)日本癌学会ヒト膵癌におけるArl4cの発現および機能解析
庄嶋 健作, 藤井 慎介, 松本 真司, 江口 英利, 土岐 祐一郎, 菊池 章
日本癌学会総会記事 Vol. 75回 p. P-2069 2016/10
Publisher: (一社)日本癌学会機能と形態の統合的アプローチによる血管・唾液腺・骨の共創的研究 WntとKITシグナルの活性化バランスによる唾液腺の形づくりと機能獲得過程の制御
松本 真司, 栗本 聖之, 藤井 慎介, 菊池 章
Journal of Oral Biosciences Supplement Vol. 2016 p. 137-137 2016/09
Publisher: (一社)歯科基礎医学会Arfファミリー低分子量Gタンパク質群が介在する多彩な生理機能と関連疾患 低分子量Gタンパク質Arl4cによる上皮の形づくりと発がんの制御
松本 真司, 藤井 慎介, 原田 武志, 菊池 章
日本生化学会大会プログラム・講演要旨集 Vol. 89回 p. [2S13-5] 2016/09
Publisher: (公社)日本生化学会肝細胞におけるLDLによるLRP6の異なるエンドサイトーシス経路の制御機構
山本 英樹, 梅田 大介, 松本 真司, 菊池 章
日本生化学会大会プログラム・講演要旨集 Vol. 89回 p. [3T14-198)] 2016/09
Publisher: (公社)日本生化学会ヒト大腸癌、肺腺癌および肺扁平上皮癌におけるArl4cの発現はがん形成を促進する
藤井 慎介, 松本 真司, 清島 保, 菊池 章
日本病理学会会誌 Vol. 105 No. 2 p. 100-100 2016/09
Publisher: (一社)日本病理学会h-Prune is associated with poor prognosis and epithelial-mesenchymal transition in patients with colorectal liver metastases
Masakazu Hashimoto, Tsuyoshi Kobayashi, Hirotaka Tashiro, Koji Arihiro, Akira Kikuchi, Hideki Ohdan
INTERNATIONAL JOURNAL OF CANCER Vol. 139 No. 4 p. 812-823 2016/08 Research paper (scientific journal)
Prickle1 promotes focal adhesion disassembly in cooperation with the CLASP-LL5 beta complex in migrating cells
Boon Cheng Lim, Shinji Matsumoto, Hideki Yamamoto, Hiroki Mizuno, Junichi Kikuta, Masaru Ishii, Akira Kikuchi
JOURNAL OF CELL SCIENCE Vol. 129 No. 16 p. 3115-3129 2016/08 Research paper (scientific journal)
The WNT/MYB pathway suppresses KIT expression to control the timing of salivary proacinar differentiation and duct formation
Shinji Matsumoto, Takayuki Kurimoto, M. Mark Taketo, Shinsuke Fujii, Akira Kikuchi
DEVELOPMENT Vol. 143 No. 13 p. 2311-2324 2016/07 Research paper (scientific journal)
CKAP4 is a Dickkopf1 receptor and is involved in tumor progression.
Hirokazu Kimura, Katsumi Fumoto, Kensaku Shojima, Satoshi Nojima, Yoshihito Osugi, Hideo Tomihara, Hidetoshi Eguchi, Yasushi Shintani, Hiroko Endo, Masahiro Inoue, Yuichiro Doki, Meinoshin Okumura, Eiichi Morii, Akira Kikuchi
The Journal of clinical investigation Vol. 126 No. 7 p. 2689-705 2016/07/01 Research paper (scientific journal)
h-prune affects anaplastic thyroid cancer invasion and metastasis
Junko Nambu, Tsuyoshi Kobayashi, Masakazu Hashimoto, Hirotaka Tashiro, Keizo Sugino, Fumio Shimamoto, Akira Kikuchi, Hideki Ohdan
ONCOLOGY REPORTS Vol. 35 No. 6 p. 3445-3452 2016/06 Research paper (scientific journal)
3次元構築の中のがん細胞 増殖因子シグナルによる上皮形態形成の分子機構とその破綻による腫瘍形成
菊池 章, 松本 真司, 藤井 慎介
日本細胞生物学会大会講演要旨集 Vol. 68回 p. 16-16 2016/05
Publisher: (一社)日本細胞生物学会WNT5a is required for normal ovarian follicle development and antagonizes gonadotropin responsiveness in granulosa cells by suppressing canonical WNT signaling
Atefeh Abedini, Gustavo Zamberlam, Evelyne Lapointe, Catherine Tourigny, Alexandre Boyer, Marilene Paquet, Kanako Hayashi, Hiroaki Honda, Akira Kikuchi, Christopher Price, Derek Boerboom
FASEB JOURNAL Vol. 30 No. 4 p. 1534-1547 2016/04 Research paper (scientific journal)
Active and water-soluble form of lipidated Wnt protein is maintained by a serum glycoprotein afamin/alpha-albumin
Emiko Mihara, Hidenori Hirai, Hideki Yamamoto, Keiko Tamura-Kawakami, Mami Matano, Akira Kikuchi, Toshiro Sato, Junichi Takagi
ELIFE Vol. 5 2016/02 Research paper (scientific journal)
器官形成における多細胞動態の階層を超えた理解に向けて Wntシグナルによる上皮管腔器官の形態形成と分化の調整
菊池 章, 藤井 慎介, 栗本 聖之, 井深 奏司, 松本 真司
日本生化学会大会・日本分子生物学会年会合同大会講演要旨集 Vol. 88回・38回 p. [4S3-5] 2015/12
Publisher: (公社)日本生化学会Greb1による尿管上皮管腔形成における細胞増殖制御機構の解析
山道 拓, 松本 真司, 菊池 章
日本生化学会大会・日本分子生物学会年会合同大会講演要旨集 Vol. 88回・38回 p. [4T3L-11(3P0942)] 2015/12
Publisher: (公社)日本生化学会Disappearance of a metastatic brain tumor and achievement of long-term survival with a good quality of life after a combination of systemic chemotherapy with the P-glycoprotein inhibitor nifedipine in a patient with ovarian cancer
Toru Yanase, Akira Kikuchi, Motoi Sasagawa, Shigeru Honma
ACTA NEUROCHIRURGICA Vol. 157 No. 12 p. 2195-2197 2015/12
ヒト大腸癌、肺腺癌および肺扁平上皮癌におけるArl4cの発現および機能解析
藤井 慎介, 松本 真司, 菊池 章
日本癌学会総会記事 Vol. 74回 p. J-1289 2015/10
Publisher: (一社)日本癌学会Arl4c expression in colorectal and lung cancers promotes tumorigenesis and may represent a novel therapeutic target
S. Fujii, S. Matsumoto, S. Nojima, E. Morii, A. Kikuchi
ONCOGENE Vol. 34 No. 37 p. 4834-4844 2015/09 Research paper (scientific journal)
The P2Y(2) receptor promotes Wnt3a-and EGF-induced epithelial tubular formation by IEC6 cells by binding to integrins
Souji Ibuka, Shinji Matsumoto, Shinsuke Fujii, Akira Kikuchi
JOURNAL OF CELL SCIENCE Vol. 128 No. 11 p. 2156-2168 2015/06 Research paper (scientific journal)
The Wnt5a-Ror2 axis promotes the signaling circuit between interleukin-12 and interferon-gamma in colitis
Akira Sato, Hisako Kayama, Kensaku Shojima, Shinji Matsumoto, Hirofumi Koyama, Yasuhiro Minami, Satoshi Nojima, Eiichi Morii, Hiroaki Honda, Kiyoshi Takeda, Akira Kikuchi
SCIENTIFIC REPORTS Vol. 5 2015/06 Research paper (scientific journal)
Basolateral secretion of Wnt5a in polarized epithelial cells is required for apical lumen formation
Hideki Yamamoto, Chihiro Awada, Shinji Matsumoto, Tomoyuki Kaneiwa, Takayuki Sugimoto, Toshifumi Takao, Akira Kikuchi
JOURNAL OF CELL SCIENCE Vol. 128 No. 5 p. 1051-1063 2015/03 Research paper (scientific journal)
Wnt5a promotes cancer cell invasion and proliferation by receptor-mediated endocytosis-dependent and -independent mechanisms, respectively
Kensaku Shojima, Akira Sato, Hideaki Hanaki, Ikuko Tsujimoto, Masahiro Nakamura, Kazunari Hattori, Yuji Sato, Keiji Dohi, Michinari Hirata, Hideki Yamamoto, Akira Kikuchi
SCIENTIFIC REPORTS Vol. 5 2015/01 Research paper (scientific journal)
【消化管の再生医療】In vitro実験系を用いた上皮管腔組織形成の分子基盤の確立
松本 真司, 菊池 章
G.I.Research Vol. 22 No. 5 p. 450-456 2014/10
Publisher: (株)先端医学社上皮組織の恒常性維持と破綻を制御するシグナル伝達経路 増殖因子のシグナル伝達による管形成の調節と発がんにおけるその関連性(Regulation of tubulogenesis by growth factor signaling and its implication in tumorigenesis)
菊池 章, 松本 真司, 藤井 慎介, 井深 奏司
日本生化学会大会プログラム・講演要旨集 Vol. 87回 p. [3S13a-3] 2014/10
Publisher: (公社)日本生化学会分化の破綻と細胞の腫瘍化 増殖因子シグナルによる上皮管腔組織形成とその破綻による発がん(Disruption of cell differentiation leading to cell transformation Epithelial tube formation by a combination of growth factor signaling and tumorigenesis due to its abnormality)
菊池 章, 松本 真司, 藤井 慎介
日本癌学会総会記事 Vol. 73回 p. S3-5 2014/09
Publisher: (一社)日本癌学会ヒト大腸癌および肺癌におけるArl4cの発現および機能解析(Arl4c expression is involved in tumorigenesis of colorectal and lung cancers)
藤井 慎介, 松本 真司, 菊池 章
日本癌学会総会記事 Vol. 73回 p. J-3060 2014/09
Publisher: (一社)日本癌学会エンドサイトーシスを介さないWnt5aシグナルによる癌細胞増殖機構の解析(Wnt5a promotes cancer cell proliferation by the endocytosis-independent pathway)
庄嶋 健作, 佐藤 朗, 山本 英樹, 辻本 育子, 松本 真司, 菊池 章
日本癌学会総会記事 Vol. 73回 p. P-3042 2014/09
Publisher: (一社)日本癌学会Modulation of Wnt Signaling by Endocytosis of Receptor Complexes
Akira Kikuchi, Shinji Matsumoto, Katsumi Fumoto, Akira Sato
Wnt Signaling in Development and Disease: Molecular Mechanisms and Biological Functions p. 113-124 2014/05/12 Part of collection (book)
Publisher: Wiley Blackwell
A combination of Wnt and growth factor signaling induces Arl4c expression to form epithelial tubular structures
Shinji Matsumoto, Shinsuke Fujii, Akira Sato, Souji Ibuka, Yoshinori Kagawa, Masaru Ishii, Akira Kikuchi
EMBO JOURNAL Vol. 33 No. 7 p. 702-718 2014/04 Research paper (scientific journal)
IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesis (vol 454, pg 345, 2008)
Weidong Zhu, Ichiro Shiojima, Yuzuru Ito, Zhi Li, Hiroyuki Ikeda, Masashi Yoshida, Atsuhiko T. Naito, Jun-ichiro Nishi, Hiroo Ueno, Akihiro Umezawa, Tohru Minamino, Toshio Nagai, Akira Kikuchi, Makoto Asashima, Issei Komuro
NATURE Vol. 506 No. 7487 p. 254-254 2014/02
Wnt5a signaling promotes apical and basolateral polarization of single epithelial cells
Hidetoshi Gon, Katsumi Fumoto, Yonson Ku, Shinji Matsumoto, Akira Kikuchi
MOLECULAR BIOLOGY OF THE CELL Vol. 24 No. 23 p. 3764-3774 2013/12 Research paper (scientific journal)
Cell Cycle-Dependent Rho GTPase Activity Dynamically Regulates Cancer Cell Motility and Invasion In Vivo
Yoshinori Kagawa, Shinji Matsumoto, Yuji Kamioka, Koshi Mimori, Yoko Naito, Taeko Ishii, Daisuke Okuzaki, Naohiro Nishida, Sakae Maeda, Atsushi Naito, Junichi Kikuta, Keizo Nishikawa, Junichi Nishimura, Naotsugu Haraguchi, Ichiro Takemasa, Tsunekazu Mizushima, Masataka Ikeda, Hirofumi Yamamoto, Mitsugu Sekimoto, Hideshi Ishii, Yuichiro Doki, Michiyuki Matsuda, Akira Kikuchi, Masaki Mori, Masaru Ishii
PLOS ONE Vol. 8 No. 12 2013/12 Research paper (scientific journal)
がんのシグナル伝達異常と分子標的治療戦略 増殖因子シグナルの協調的作用による上皮管腔形成と腫瘍形成の制御(Aberrant signal transduction and therapeutic strategy for molecular target Regulation of tubulogenesis and tumorigenesis by a combination of growth factor signaling)
菊池 章, 松本 真司, 藤井 慎介, 佐藤 朗, 井深 奏司
日本癌学会総会記事 Vol. 72回 p. 51-51 2013/10
Publisher: (一社)日本癌学会Wnt5aシグナルによる癌細胞増殖機構の解析(Wnt5a regulates cancer cell proliferation)
庄嶋 健作, 佐藤 朗, 辻本 育子, 松本 真司, 菊池 章
日本癌学会総会記事 Vol. 72回 p. 99-99 2013/10
Publisher: (一社)日本癌学会The apical and basolateral secretion of Wnt11 and Wnt3a in polarized epithelial cells is regulated by different mechanisms
Hideki Yamamoto, Chihiro Awada, Hideaki Hanaki, Hiroshi Sakane, Ikuko Tsujimoto, Yuko Takahashi, Toshifumi Takao, Akira Kikuchi
JOURNAL OF CELL SCIENCE Vol. 126 No. 13 p. 2931-2943 2013/07 Research paper (scientific journal)
[Canonical Wnt signaling pathway and cellular responses].
Kikuchi A
Clinical calcium Vol. 23 No. 6 p. 799-807 2013/06
Low-density lipoprotein receptor-related protein 6の毛細胆管における局在とトランスサイトーシスに関する研究
梅田 大介, 山本 英樹, 松本 真司, 菊池 章
日本生化学会大会プログラム・講演要旨集 Vol. 85回 p. 3T02-03 2012/12
Publisher: (公社)日本生化学会Wnt5a signaling controls cytokinesis by correctly positioning ESCRT-III at the midbody
Katsumi Fumoto, Koji Kikuchi, Hidetoshi Gon, Akira Kikuchi
JOURNAL OF CELL SCIENCE Vol. 125 No. 20 p. 4822-4832 2012/10 Research paper (scientific journal)
Complement C1q Activates Canonical Wnt Signaling and Promotes Aging-Related Phenotypes (vol 149, pg 1298, 2012)
Naito Atsuhiko T, Sumida Tomokazu, Nomura Seitaro, Liu Mei-Lan, Higo Tomoaki, Nakagawa Akito, Okada Katsuki, Sakai Taku, Hashimoto Akihito, Hara Yurina, Shimizu Ippei, Zhu Weidong, Toko Haruhiro, Katada Akemi, Akazawa Hiroshi, Oka Toru, Lee Jong-Kook, Minamino Tohru, Nagai Toshio, Walsh Kenneth, Kikuchi Akira, Matsumoto Misako, Botto Marina, Shiojima Ichiro, Komuro Issei
CELL Vol. 150 No. 3 p. 659-660 2012/08/03
Complement C1q Activates Canonical Wnt Signaling and Promotes Aging-Related Phenotypes
Naito Atsuhiko T, Sumida Tomokazu, Nomura Seitaro, Liu Mei-Lan, Higo Tomoaki, Nakagawa Akito, Okada Katsuki, Sakai Taku, Hashimoto Akihito, Hara Yurina, Shimizu Ippei, Zhu Weidong, Toko Haruhiro, Katada Akemi, Akazawa Hiroshi, Oka Toru, Lee Jong-Kook, Minamino Tohru, Nagai Toshio, Walsh Kenneth, Kikuchi Akira, Matsumoto Misako, Botto Marina, Shiojima Ichiro, Komuro Issei
CELL Vol. 149 No. 6 p. 1298-1313 2012/06/08 Research paper (scientific journal)
The Dishevelled-associating protein Daple controls the non-canonical Wnt/Rac pathway and cell motility.
Maki Ishida-Takagishi, Atsushi Enomoto, Naoya Asai, Kaori Ushida, Takashi Watanabe, Takahiko Hashimoto, Takuya Kato, Liang Weng, Shinji Matsumoto, Masato Asai, Yoshiki Murakumo, Kozo Kaibuchi, Akira Kikuchi, Masahide Takahashi
Nature communications Vol. 3 p. 859-859 2012/05/29 Research paper (scientific journal)
An Anti-Wnt5a Antibody Suppresses Metastasis of Gastric Cancer Cells In Vivo by Inhibiting Receptor-Mediated Endocytosis
Hideaki Hanaki, Hideki Yamamoto, Hiroshi Sakane, Shinji Matsumoto, Hideki Ohdan, Akira Sato, Akira Kikuchi
MOLECULAR CANCER THERAPEUTICS Vol. 11 No. 2 p. 298-307 2012/02 Research paper (scientific journal)
Regulation of focal adhesion dynamics by Wnt5a signaling
Shinji Matsumoto, Akira Kikuchi
Methods in Molecular Biology Vol. 839 p. 215-227 2012 Research paper (scientific journal)
Localization of glypican-4 in different membrane microdomains is involved in the regulation of Wnt signaling
Hiroshi Sakane, Hideki Yamamoto, Shinji Matsumoto, Akira Sato, Akira Kikuchi
JOURNAL OF CELL SCIENCE Vol. 125 No. 2 p. 449-460 2012/01 Research paper (scientific journal)
Waif1/5T4 Inhibits Wnt/β-Catenin Signaling and Activates Noncanonical Wnt Pathways by Modifying LRP6 Subcellular Localization
Birgit Kagermeier-Schenk, Daniel Wehner, Günes Özhan-Kizil, Hideki Yamamoto, Jian Li, Katharina Kirchner, Christian Hoffmann, Peter Stern, Akira Kikuchi, Alexandra Schambony, Gilbert Weidinger
Developmental Cell Vol. 21 No. 6 p. 1129-1143 2011/12/13 Research paper (scientific journal)
Insufficiency of BUBR1, a mitotic spindle checkpoint regulator, causes impaired ciliogenesis in vertebrates
Tatsuo Miyamoto, Sean Porazinski, Huijia Wang, Antonia Borovina, Brian Ciruna, Atsushi Shimizu, Tadashi Kajii, Akira Kikuchi, Makoto Furutani-Seiki, Shinya Matsuura
HUMAN MOLECULAR GENETICS Vol. 20 No. 10 p. 2058-2070 2011/05 Research paper (scientific journal)
Sumatriptan as a treatment for cyclic vomiting syndrome: A clinical trial
Toshiyuki Hikita, Hiroko Kodama, Sono Kaneko, Kaori Amakata, Kaori Ogita, Daishi Mochizuki, Fumiaya Kaga, Natsue Nakamoto, Yasushi Fujii, Akira Kikuchi
CEPHALALGIA Vol. 31 No. 4 p. 504-507 2011/03
MMP-10/stromelysin-2 promotes invasion of head and neck cancer.
Elsayed Mohamed Deraz, Yasusei Kudo, Maki Yoshida, Mariko Obayashi, Takaaki Tsunematsu, Hirotaka Tani, Samadarani B S M Siriwardena, Mohammad Reza Keikhaee, Guangying Qi, Shinji Iizuka, Ikuko Ogawa, Giuseppina Campisi, Lorenzo Lo Muzio, Yoshimitsu Abiko, Akira Kikuchi, Takashi Takata
PloS one Vol. 6 No. 10 2011 Research paper (scientific journal)
NEW INSIGHTS INTO THE MECHANISM OF WNT SIGNALING PATHWAY ACTIVATION
Akira Kikuchi, Hideki Yamamoto, Akira Sato, Shinji Matsumoto
INTERNATIONAL REVIEW OF CELL AND MOLECULAR BIOLOGY, VOL 291 Vol. 291 p. 21-71 2011 Part of collection (book)
Determination and Disruption of Polarity in Cell and Tissue Morphogenesis 三次元培養下での細胞極性による上皮形態形成の制御(Determination and Disruption of Polarity in Cell and Tissue Morphogenesis Epithelial morphogenesis regulated by cell polarity in three-dimensional culture)
菊池 章, 松本 真司, 佐藤 朗, 山本 英樹
日本生化学会大会・日本分子生物学会年会合同大会講演要旨集 Vol. 83回・33回 p. 1S3-1 2010/12
Publisher: (公社)日本生化学会GSK3 regulates the expressions of human and mouse c-Myb via different mechanisms
Kyoko Kitagawa, Yojiro Kotake, Yoshihiro Hiramatsu, Ning Liu, Sayuri Suzuki, Satoki Nakamura, Akira Kikuchi, Masatoshi Kitagawa
CELL DIVISION Vol. 5 2010/11 Research paper (scientific journal)
Dishevelled, a Wnt signalling component, is involved in mitotic progression in cooperation with Plk1
Koji Kikuchi, Yohei Niikura, Katsumi Kitagawa, Akira Kikuchi
EMBO JOURNAL Vol. 29 No. 20 p. 3470-3483 2010/10 Research paper (scientific journal)
Ror2/Frizzled complex mediates Wnt5a-induced AP-1 activation by regulating Dishevelled polymerization.
Michiru Nishita, Sumiyo Itsukushima, Akira Nomachi, Mitsuharu Endo, ZhiChao Wang, Daisuke Inaba, Sen Qiao, Shinji Takada, Akira Kikuchi, Yasuhiro Minami
Molecular and cellular biology Vol. 30 No. 14 p. 3610-9 2010/07 Research paper (scientific journal)
Wnt5a signaling is involved in the aggressiveness of prostate cancer and expression of metalloproteinase
Yamamoto, H, Oue, N, Sato, A, Hasegawa, Y, Yamamoto, H, Matsubara, A, Yasui, W, Kikuchi, A
ONCOGENE Vol. 29 No. 14 p. 2036-2046 2010/04/08 Research paper (scientific journal)
Publisher: NATURE PUBLISHING GROUP
Binding of APC and dishevelled mediates Wnt5a-regulated focal adhesion dynamics in migrating cells
Shinji Matsumoto, Katsumi Fumoto, Tetsuji Okamoto, Kozo Kaibuchi, Akira Kikuchi
EMBO JOURNAL Vol. 29 No. 7 p. 1192-1204 2010/04 Research paper (scientific journal)
LRP6 is internalized by Dkk1 to suppress its phosphorylation in the lipid raft and is recycled for reuse
Hiroshi Sakane, Hideki Yamamoto, Akira Kikuchi
Journal of Cell Science Vol. 123 No. 3 p. 360-368 2010/02/01 Research paper (scientific journal)
The PHCCEx domain of Tiam1/2 is a novel protein- and membrane-binding module
Shin-ichi Terawaki, Ken Kitano, Tomoyuki Mori, Yan Zhai, Yoshiki Higuchi, Norimichi Itoh, Takashi Watanabe, Kozo Kaibuchi, Toshio Hakoshima
EMBO JOURNAL Vol. 29 No. 1 p. 236-250 2010/01 Research paper (scientific journal)
Wnt5a regulates distinct signalling pathways by binding to Frizzled2
Akira Sato, Hideki Yamamoto, Hiroshi Sakane, Hirofumi Koyama, Akira Kikuchi
EMBO JOURNAL Vol. 29 No. 1 p. 41-54 2010/01 Research paper (scientific journal)
Retinoic acid induces discrete Wnt-signaling-dependent differentiation in F9 cells
Atsuko Inoue, Akira Nagafuchi, Akira Kikuchi
Biochemical and Biophysical Research Communications Vol. 390 No. 3 p. 564-569 2009/12/18 Research paper (scientific journal)
三次元培養法を用いたDishevelledによる分枝形態形成制御機構についての解析
松本 真司, 菊池 章, 岡本 哲治
日本口腔科学会雑誌 Vol. 58 No. 4 p. 292-293 2009/09
Publisher: (NPO)日本口腔科学会Laminin gamma 2 Mediates Wnt5a-Induced Invasion of Gastric Cancer Cells
Hideki Yamamoto, Yasuhiko Kitadai, Hideki Yamamoto, Naohide Oue, Hideki Ohdan, Wataru Yasui, Akira Kikuchi
GASTROENTEROLOGY Vol. 137 No. 1 p. 242-252 2009/07 Research paper (scientific journal)
Axin localizes to the centrosome and is involved in microtubule nucleation
Katsumi Fumoto, Moe Kadono, Nanae Izumi, Akira Kikuchi
EMBO REPORTS Vol. 10 No. 6 p. 606-613 2009/06 Research paper (scientific journal)
H-prune is an independent prognostic marker for survival in Esophageal squamous cell carcinoma
Tsuyoshi Noguchi, Naohide Oue, Shinsuke Wada, Kazuhiro Sentani, Naoya Sakamoto, Akira Kikuchi, Wataru Yasui
Annals of Surgical Oncology Vol. 16 No. 5 p. 1390-1396 2009/05 Research paper (scientific journal)
Unc5B associates with LARG to mediate the action of repulsive guidance molecule
Katsuhiko Hata, Kozo Kaibuchi, Shinobu Inagaki, Toshihide Yamashita
JOURNAL OF CELL BIOLOGY Vol. 184 No. 5 p. 737-750 2009/03 Research paper (scientific journal)
Selective activation mechanisms of Wnt signaling pathways
Akira Kikuchi, Hideki Yamamoto, Akira Sato
TRENDS IN CELL BIOLOGY Vol. 19 No. 3 p. 119-129 2009/03
CHD8 suppresses p53-mediated apoptosis through histone H1 recruitment during early embryogenesis
Masaaki Nishiyama, Kiyotaka Oshikawa, Yu-ichi Tsukada, Tadashi Nakagawa, Shun-ichiro Iemura, Tohru Natsume, Yuhong Fan, Akira Kikuchi, Arthur I. Skoultchi, Keiichi I. Nakayama
NATURE CELL BIOLOGY Vol. 11 No. 2 p. 172-U139 2009/02 Research paper (scientific journal)
Fbw7 promotes ubiquitin-dependent degradation of c-Myb: involvement of GSK3-mediated phosphorylation of Thr-572 in mouse c-Myb.
Kitagawa, K, Hiramatsu, Y, Uchida, C, Isobe, T, Hattori, T, Oda, T, Shibata, K, Nakamura, S, Kikuchi, A, Kitagawa, M
Oncogene Vol. 28 No. 25 p. 2393-405 2009
[Activation of the beta-catenin-independent pathway by Wnt and the diseases due to its abnormality].
Kikuchi A, Yamamoto H, Sato A
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme Vol. 54 No. 1 p. 1-10 2009/01
Wnt signaling; its abnormalities and diseases
Akira Kikuchi
Seikagaku Vol. 81 No. 9 p. 780-792 2009 Research paper (scientific journal)
3次元培養を用いたDishevelledによる細胞運動・形態形成制御機構の解析
松本 真司, 麓 勝己, 菊池 章
日本生化学会大会・日本分子生物学会年会合同大会講演要旨集 Vol. 81回・31回 p. 3T12-5 2008/11
Publisher: (公社)日本生化学会IFN-Induced Transmembrane Protein 1 Promotes Invasion at Early Stage of Head and Neck Cancer Progression
Hiroko Hatano, Yasusei Kudo, Ikuko Ogawa, Takaaki Tsunematsu, Akira Kikuchi, Yoshimitsu Abiko, Takashi Takata
CLINICAL CANCER RESEARCH Vol. 14 No. 19 p. 6097-6105 2008/10 Research paper (scientific journal)
AIP regulates stability of Aurora-A at early mitotic phase coordinately with GSK-3 beta
K. Fumoto, P-C Lee, H. Saya, A. Kikuchi
ONCOGENE Vol. 27 No. 32 p. 4478-4487 2008/07 Research paper (scientific journal)
IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesis
Weidong Zhu, Ichiro Shiojima, Yuzuru Ito, Zhi Li, Hiroyuki Ikeda, Masashi Yoshida, Atsuhiko T. Naito, Jun-ichiro Nishi, Hiroo Ueno, Akihiro Umezawa, Tohru Minamino, Toshio Nagai, Akira Kikuchi, Makoto Asashima, Issei Komuro
NATURE Vol. 454 No. 7202 p. 345-U51 2008/07 Research paper (scientific journal)
Polycomb-group complex 1 acts as an E3 ubiquitin ligase for Geminin to sustain hematopoietic stem cell activity
Motoaki Ohtsubo, Shin'ichiro Yasunaga, Yoshinori Ohno, Miyuki Tsumura, Satoshi Okada, Nobutsune Ishikawa, Kenichiro Shirao, Akira Kikuchi, Hideo Nishitani, Masao Kobayashi, Yoshihiro Takihara
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA Vol. 105 No. 30 p. 10396-10401 2008/07 Research paper (scientific journal)
Wnt3a and Dkk1 regulate distinct internalization pathways of LRP6 to tune the activation of beta-catenin signaling
Hideki Yamamoto, Hiroshi Sakane, Hideki Yamamoto, Tatsuo Michiue, Akira Kikuchi
DEVELOPMENTAL CELL Vol. 15 No. 1 p. 37-48 2008/07 Research paper (scientific journal)
GSK-3 beta regulates proper mitotic spindle formation in cooperation with a component of the gamma-tubulin ring complex, GCP5
Nanae Izumi, Katsumi Fumoto, Shunsuke Izumi, Akira Kikuchi
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 283 No. 19 p. 12981-12991 2008/05 Research paper (scientific journal)
Tumor formation due to abnormalities in the beta-catenin-independent pathway of Wnt signaling
Akira Kikuchi, Hideki Yamamoto
CANCER SCIENCE Vol. 99 No. 2 p. 202-208 2008/02
Wnt5a modulates glycogen synthase kinase 3 to induce phosphorylation of receptor tyrosine kinase Ror2.
Hiroyuki Yamamoto, Sa Kan Yoo, Michiru Nishita, Akira Kikuchi, Yasuhiro Minami
Genes to cells : devoted to molecular & cellular mechanisms Vol. 12 No. 11 p. 1215-23 2007/11 Research paper (scientific journal)
Rho-kinase activation in endothelial cells contributes to expansion of infarction after focal cerebral ischemia
Yoshiki Yagita, Kazuo Kitagawa, Tsutomu Sasaki, Yasukazu Terasaki, Kenichi Todo, Emi Omura-Matsuoka, Kozo Kaibuchi, Masatsugu Hori
JOURNAL OF NEUROSCIENCE RESEARCH Vol. 85 No. 11 p. 2460-2469 2007/08 Research paper (scientific journal)
Increased expression of h-prune is associated with tumor progression and poor survival in gastric cancer
Naohide Oue, Kazuhiro Yoshida, Tsuyoshi Noguchi, Kazuhiro Sentani, Akira Kikuchi, Wataru Yasui
CANCER SCIENCE Vol. 98 No. 8 p. 1198-1205 2007/08 Research paper (scientific journal)
Structural basis for tubulin recognition by cytoplasmic linker protein 170 and its autoinhibition
Masaki Mishima, Ryoko Maesaki, Miyuki Kasa, Takashi Watanabe, Masaki Fukata, Kozo Kaibuchi, Toshio Hakoshima
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA Vol. 104 No. 25 p. 10346-10351 2007/06 Research paper (scientific journal)
Noncovalent binding of small ubiquitin-related modifier (SUMO) protease to SUMO is necessary for enzymatic activities and cell growth.
Motomasa Ihara, Hirofumi Koyama, Yasuhiro Uchimura, Hisato Saitoh, Akira Kikuchi
The Journal of biological chemistry Vol. 282 No. 22 p. 16465-75 2007/06/01 Research paper (scientific journal)
The DIX domain of Dishevelled confers Wnt signaling by dynamic polymerization
Thomas Schwarz-Romond, Marc Fiedler, Naoki Shibata, P. Jonathan G. Butler, Akira Kikuchi, Yoshiki Higuchi, Mariann Bienz
Nature Structural and Molecular Biology Vol. 14 No. 6 p. 484-492 2007/06 Research paper (scientific journal)
Crystallization and preliminary X-ray crystallographic studies of the axin DIX domain
Naoki Shibata, Yusuke Tomimoto, Toru Hanamura, Ryo Yamamoto, Mai Ueda, Yasufumi Ueda, Nobuhiro Mizuno, Hideaki Ogata, Hirofumi Komori, Yasuhito Shomura, Michihiko Kataoka, Sakayu Shimizu, Jun Kondo, Hideki Yamamoto, Akira Kikuchi, Yoshiki Higuchi
Acta Crystallographica Section F: Structural Biology and Crystallization Communications Vol. 63 No. 6 p. 529-531 2007/05/05 Research paper (scientific journal)
Glycosylation and palmitoylation of Wnt-3a are coupled to produce an active form of Wnt-3a
Hideyuki Komekado, Hideki Yamamoto, Tsutomu Chiba, Akira Kikuchi
GENES TO CELLS Vol. 12 No. 4 p. 521-534 2007/04 Research paper (scientific journal)
Multiplicity of the interactions of Wnt proteins and their receptors
Akira Kikuchi, Hideki Yamamoto, Shosei Kishida
CELLULAR SIGNALLING Vol. 19 No. 4 p. 659-671 2007/04
Post-translational palmitoylation and glycosylation of Wnt-5a are necessary for its signalling
Manabu Kurayoshi, Hideki Yamamoto, Shunsuke Izumi, Akira Kikuchi
BIOCHEMICAL JOURNAL Vol. 402 p. 515-523 2007/03 Research paper (scientific journal)
1P018 Structural basis of dynamic polymerization of D1X domains: a revised model of Wnt signaling(Proteins-structure and structure-function relationship,Oral Presentations)
Shibata Naoki, Schwarz-Romond Thomas, Fiedler Marc, Butler P. Jonathan G., Komori Hirofumi, Shomura Yasuhito, Yamamoto Hideki, Kikuchi Akira, Bienz Mariann, Higuchi Yoshiki
Seibutsu Butsuri Vol. 47 2007
Publisher: The Biophysical Society of Japan General Incorporated Association
Sprouty2 and Sprouty4 are essential for embryonic morphogenesis and regulation of FGF signaling
Koji Taniguchi, Toranoshin Ayada, Kenji Ichiyama, Ri-ichiro Kohno, Yoshikazu Yonemitsu, Yasuhiro Minami, Akira Kikuchi, Yoshihiko Maehara, Akihiko Yoshimura
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Vol. 352 No. 4 p. 896-902 2007/01 Research paper (scientific journal)
Dvl regulates endo- and exocytotic processes through binding to synaptotagmin.
Kishida, S, Hamao, K, Inoue, M, Hasegawa, M, Matsuura, Y, Mikoshiba, K, Fukuda, M, Kikuchi, A
Genes Cells Vol. 12 No. 1 p. 49-61 2007/01 Research paper (scientific journal)
GSK-3 beta-regulated interaction of BICD with dynein is involved in microtubule anchorage at centrosome
Katsumi Fumoto, Casper C. Hoogenraad, Akira Kikuchi
EMBO JOURNAL Vol. 25 No. 24 p. 5670-5682 2006/12 Research paper (scientific journal)
Developmental stage-specific biphasic roles of Wnt/beta-catenin signaling in cardiomyogenesis and hematopoiesis
Atsuhiko T. Naito, Ichiro Shiojima, Hiroshi Akazawa, Kyoko Hidaka, Takayuki Morisaki, Akira Kikuchi, Issei Komuro
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA Vol. 103 No. 52 p. 19812-19817 2006/12 Research paper (scientific journal)
Expression of Wnt-5a is correlated with aggressiveness of gastric cancer by stimulating cell migration and invasion
Kurayoshi, Manabu, Oue, Naohide, Yamamoto, Hideki, Kishida, Michiko, Inoue, Atsuko, Asahara, Toshimasa, Yasui, Wataru, Kikuchi, Akira
CANCER RESEARCH Vol. 66 No. 21 p. 10439-10448 2006/11/01 Research paper (scientific journal)
Publisher: AMER ASSOC CANCER RESEARCH
Filopodia formation mediated by receptor tyrosine kinase Ror2 is required for Wnt5a-induced cell migration
Michiru Nishita, So Kan Yoo, Akira Nomachi, Shuichi Kani, Nagako Sougawa, Yasutaka Ohta, Shinji Takada, Akira Kikuchi, Yasuhiro Minami
JOURNAL OF CELL BIOLOGY Vol. 175 No. 4 p. 555-562 2006/11 Research paper (scientific journal)
Caveolin is necessary for Wnt-3a-dependent internalization of LRP6 and accumulation of beta-catenin
Hideki Yamamoto, Hideyuki Komekado, Akira Kikuchi
DEVELOPMENTAL CELL Vol. 11 No. 2 p. 213-223 2006/08 Research paper (scientific journal)
[Abnormal regulation of beta-catenin degradation through ubiquitination as a mechanism of carcinogenesis].
Kikuchi A, Kishida S
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme Vol. 51 No. 10 Suppl p. 1271-1276 2006/08
Oog1, an oocyte-specific protein, interacts with Ras and Ras-signaling proteins during early embryogenesis
S Tsukamoto, R Ihara, A Aizawa, S Kishida, A Kikuchi, H Imai, N Minami
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Vol. 343 No. 4 p. 1105-1112 2006/05 Research paper (scientific journal)
Regulation of Wnt signaling by protein-protein interaction and post-translational modifications
A Kikuchi, S Kishida, H Yamamoto
EXPERIMENTAL AND MOLECULAR MEDICINE Vol. 38 No. 1 p. 1-10 2006/02
Glycogen synthase kinase 3 and h-prune regulate cell migration by modulating focal adhesions
Tsuyoshi Kobayashi, Shin-Ichiro Hino, Naohide Oue, Toshimasa Asahara, Massimo Zollo, Wataru Yasui, Akira Kikuchi
Molecular and Cellular Biology Vol. 26 No. 3 p. 898-911 2006/02 Research paper (scientific journal)
Suppression of STAT3 activity by duplin, which is a negative regulator of the Wnt signal
Yamashina, K, Yamamoto, H, Chayama, K, Nakajima, K, Kikuchi, A
JOURNAL OF BIOCHEMISTRY Vol. 139 No. 2 p. 305-314 2006/02 Research paper (scientific journal)
Publisher: JAPANESE BIOCHEMICAL SOC
Novel Daple-like protein positively regulates both the Wnt/beta-catenin pathway and the Wnt/JNK pathway in Xenopus
H Kobayashi, T Michiue, A Yukita, H Danno, K Sakurai, A Fukui, A Kikuchi, M Asashima
MECHANISMS OF DEVELOPMENT Vol. 122 No. 10 p. 1138-1153 2005/10 Research paper (scientific journal)
Phosphorylation of beta-catenin by cyclic AMP-dependent protein kinase stabilizes beta-catenin through inhibition of its ubiquitination
S Hino, C Tanji, KI Nakayama, A Kikuchi
MOLECULAR AND CELLULAR BIOLOGY Vol. 25 No. 20 p. 9063-9072 2005/10 Research paper (scientific journal)
SUMO-1 modification of PIASy, an E3 ligase, is necessary for PIASy-dependent activation of Tcf-4
M Ihara, H Yamamoto, A Kikuchi
MOLECULAR AND CELLULAR BIOLOGY Vol. 25 No. 9 p. 3506-3518 2005/05 Research paper (scientific journal)
Ubquitin-interacting motifs of epsin are involved in the regulation of insulin-dependent endocytosis
S Sugiyama, S Kishida, K Chayama, S Koyama, A Kikuchi
JOURNAL OF BIOCHEMISTRY Vol. 137 No. 3 p. 355-364 2005/03 Research paper (scientific journal)
GSK-3β regulates phosphorylation of CRMP-2 and neuronal polarity
Takeshi Yoshimura, Yoji Kawano, Nariko Arimura, Saeko Kawabata, Akira Kikuchi, Kozo Kaibuchi
Cell Vol. 120 No. 1 p. 137-149 2005/01/14 Research paper (scientific journal)
The receptor tyrosine kinase Ror2 associates with and is activated by casein kinase Iepsilon.
Shuichi Kani, Isao Oishi, Hiroyuki Yamamoto, Akinori Yoda, Hiroaki Suzuki, Akira Nomachi, Kengo Iozumi, Michiru Nishita, Akira Kikuchi, Toru Takumi, Yasuhiro Minami
The Journal of biological chemistry Vol. 279 No. 48 p. 50102-9 2004/11/26 Research paper (scientific journal)
Publisher: 48
Small ubiquitin-like modifier 1 (SUMO-1) modification of the synergy control motif of Ad4 binding protein/steroidogenic factor 1 (Ad4BP/SF-1) regulates synergistic transcription between Ad4BP/SF-1 and Sox9
T Komatsu, H Mizusaki, T Mukai, H Ogawa, D Baba, M Shirakawa, S Hatakeyama, KI Nakayama, H Yamamoto, A Kikuchi, KI Morohashi
MOLECULAR ENDOCRINOLOGY Vol. 18 No. 10 p. 2451-2462 2004/10 Research paper (scientific journal)
Early embryonic death in mice lacking the beta-catenin-binding protein duplin
M Nishiyama, K Nakayama, R Tsunematsu, T Tsukiyama, A Kikuchi, KI Nakayama
MOLECULAR AND CELLULAR BIOLOGY Vol. 24 No. 19 p. 8386-8394 2004/10 Research paper (scientific journal)
Galectin-3, a novel binding partner of β-catenin
Tatsuo Shimura, Yukinori Takenaka, Souichi Tsutsumi, Victor Hogan, Akira Kikuchi, Avraham Raz
Cancer Research Vol. 64 No. 18 p. 6363-6367 2004/09/15 Research paper (scientific journal)
Mesenchymal-epithelial transition during somitic segmentation is regulated by differential roles of Cdc42 and Rac1
Y Nakaya, S Kuroda, YT Katagiri, K Kaibuchi, Y Takahashi
DEVELOPMENTAL CELL Vol. 7 No. 3 p. 425-438 2004/09 Research paper (scientific journal)
XSENP1, a novel sumo-specific protease in Xenopus, inhibits normal head formation by down-regulation of Wnt/beta-catenin signalling
A Yukita, T Michiue, A Fukui, K Sakurai, H Yamamoto, M Ihara, A Kikuchi, M Asashima
GENES TO CELLS Vol. 9 No. 8 p. 723-736 2004/08 Research paper (scientific journal)
Synaptic scaffolding molecule interacts with axin.
Hirabayashi S, Nishimura W, Iida J, Kansaku A, Kishida S, Kikuchi A, Tanaka N, Hata Y
Journal of neurochemistry Vol. 90 No. 2 p. 332-339 2004/07
Publisher: 2
Sall1, a causative gene for Townes-Brocks syndrome, enhances the canonical Wnt signaling by localizing to heterochromatin
A Sato, S Kishida, T Tanaka, A Kikuchi, T Kodama, M Asashima, R Nishinakamura
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Vol. 319 No. 1 p. 103-113 2004/06 Research paper (scientific journal)
Immunohistochemical analysis and mutational analyses of beta-catenin, Axin family and APC genes in hepatocellular carcinomas
Y Ishizaki, S Ikeda, M Fujimori, Y Shimizu, T Kurihara, T Itamoto, A Kikuchi, M Okajima, T Asahara
INTERNATIONAL JOURNAL OF ONCOLOGY Vol. 24 No. 5 p. 1077-1083 2004/05 Research paper (scientific journal)
Wnt-3a and Dvl induce neurite retraction by activating Rho-associated kinase
S Kishida, H Yamamoto, A Kikuchi
MOLECULAR AND CELLULAR BIOLOGY Vol. 24 No. 10 p. 4487-4501 2004/05 Research paper (scientific journal)
Xldax, an inhibitor of the canonical Wnt pathway, is required for anterior neural structure formation in Xenopus
T Michiue, A Fukui, A Yukita, K Sakurai, H Danno, A Kikuchi, M Asashima
DEVELOPMENTAL DYNAMICS Vol. 230 No. 1 p. 79-90 2004/05 Research paper (scientific journal)
Glycogen Synthase Kinase-3β Is Involved in the Phosphorylation and Suppression of Androgen Receptor Activity
Thomas R. Salas, Jeri Kim, Funda Vakar-Lopez, Anita L. Sabichi, Patricia Troncoso, Guido Jenster, Akira Kikuchi, Shao-Yong Chen, Lirim Shemshedini, Milind Suraokar, Christopher J. Logothetis, John DiGiovanni, Scott M. Lippman, David G. Menter
Journal of Biological Chemistry Vol. 279 No. 18 p. 19191-19200 2004/04/30 Research paper (scientific journal)
Inhibition of the canonical Wnt signaling pathway in cytoplasm: a novel property of the carboxyl terminal domains of two Xenopus ELL genes
K Sakurai, T Michiue, A Kikuchi, M Asashima
ZOOLOGICAL SCIENCE Vol. 21 No. 4 p. 407-416 2004/04 Research paper (scientific journal)
Positive role of IQGAP1, an effector of Rac1, in actin-meshwork formation at sites of cell-cell contact
J Noritake, M Fukata, K Sato, M Nakagawa, T Watanabe, N Izumi, SJ Wang, Y Fukata, K Kaibuchi
MOLECULAR BIOLOGY OF THE CELL Vol. 15 No. 3 p. 1065-1076 2004/03 Research paper (scientific journal)
Siah-1 facilitates ubiquitination and degradation of synphilin-1.
Nagano Y, Yamashita H, Takahashi T, Kishida S, Nakamura T, Iseki E, Hattori N, Mizuno Y, Kikuchi A, Matsumoto M
The Journal of biological chemistry Vol. 278 No. 51 p. 51504-51514 2003/12
Identification and characterization of a novel Dvl-binding protein that suppresses Wnt signalling pathway
A Oshita, S Kishida, H Kobayashi, T Michiue, T Asahara, M Asashima, A Kikuchi
GENES TO CELLS Vol. 8 No. 12 p. 1005-1017 2003/12 Research paper (scientific journal)
Alleviating the Suppression of Glycogen Synthase Kinase-3β by Akt Leads to the Phosphorylation of cAMP-response Element-binding Protein and Its Transactivation in Intact Cell Nuclei
Thomas R. Salas, Shrikanth A. Reddy, John L. Clifford, Roger J. Davis, Akira Kikuchi, Scott M. Lippman, David G. Menter
Journal of Biological Chemistry Vol. 278 No. 42 p. 41338-41346 2003/10/17 Research paper (scientific journal)
Roles of Rho-family GTPases in cell polarisation and directional migration
M Fukata, M Nakagawa, K Kaibuchi
CURRENT OPINION IN CELL BIOLOGY Vol. 15 No. 5 p. 590-597 2003/10
Neurofibromatosis type I tumor suppressor neurofibromin regulates neuronal differentiation via its GTPase-activating protein function toward Ras
Shunji Yunoue, Hiroshi Tokuo, Kohji Fukunaga, Liping Feng, Tatsuya Ozawa, Toru Nishi, Akira Kikuchi, Seisuke Hattori, Junichi Kuratsu, Hideyuki Saya, Norie Araki
Journal of Biological Chemistry Vol. 278 No. 29 p. 26958-26969 2003/07/18 Research paper (scientific journal)
Impaired degradation of inhibitory subunit of NF-kappa B (I kappa B) and beta-catenin as a result of targeted disruption of the beta-TrCP1 gene
K Nakayama, S Hatakeyama, S Maruyama, A Kikuchi, K Onoe, RA Good, KI Nakayama
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA Vol. 100 No. 15 p. 8752-8757 2003/07 Research paper (scientific journal)
β-カテニン結合蛋白質Duplinの核内輸送の分子機構とその意義
小林 雅史, 菊池 章, 岡本 哲治
口腔組織培養学会誌 Vol. 12 No. 1 p. 31-32 2003/03
Publisher: 日本口腔組織培養学会Regulation of type 1 protein phosphatase/inhibitor-2 complex by glycogen synthase kinase-3 beta in intact cells
G Sakashita, H Shima, M Komatsu, T Urano, A Kikuchi, K Kikuchi
JOURNAL OF BIOCHEMISTRY Vol. 133 No. 2 p. 165-171 2003/02 Research paper (scientific journal)
PY motifs of Rod1 are required for binding to Rsp5 and for drug resistance
T Andoh, Y Hirata, A Kikuchi
FEBS LETTERS Vol. 525 No. 1-3 p. 131-134 2002/08 Research paper (scientific journal)
Rac1 and Cdc42 capture microtubules through IQGAP1 and CLIP-170
M Fukata, T Watanabe, J Noritake, M Nakagawa, M Yamaga, S Kuroda, Y Matsuura, A Iwamatsu, F Perez, K Kaibuchi
CELL Vol. 109 No. 7 p. 873-885 2002/06 Research paper (scientific journal)
Rho-family GTPases in cadherin-mediated cell-cell adhesion
M Fukata, K Kaibuchi
NATURE REVIEWS MOLECULAR CELL BIOLOGY Vol. 2 No. 12 p. 887-897 2001/12
β-カテニン結合蛋白質Duplinの核内輸送の分子機構
小林 雅史, 岸田 昭世, 宮本 洋一, 米田 悦啓, 菊池 章, 岡本 哲治
日本口腔科学会雑誌 Vol. 50 No. 6 p. 568-569 2001/11
Publisher: (NPO)日本口腔科学会Recruitment and activation of Rac1 by the formation of E-cadherin-mediated cell-cell adhesion sites
M Nakagawa, M Fukata, M Yamaga, N Itoh, K Kaibuchi
JOURNAL OF CELL SCIENCE Vol. 114 No. 10 p. 1829-1838 2001/05 Research paper (scientific journal)
Involvement of IQGAP1, an effector of Rac1 and Cdc42 GTPases, in cell-cell dissociation during cell scattering
M Fukata, M Nakagawa, N Itoh, A Kawajiri, M Yamaga, S Kuroda, K Kaibuchi
MOLECULAR AND CELLULAR BIOLOGY Vol. 21 No. 6 p. 2165-2183 2001/03 Research paper (scientific journal)
Identification of a novel beta-catenin-interacting protein
A Kawajiri, N Itoh, M Fukata, M Nakagawa, M Yamaga, A Iwamatsu, K Kaibuchi
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Vol. 273 No. 2 p. 712-717 2000/07 Research paper (scientific journal)
Phosphorylation of ERM proteins at filopodia induced by Cdc42
N Nakamura, N Oshiro, Y Fukata, M Amano, M Fukata, S Kuroda, Y Matsuura, T Leung, L Lim, K Kaibuchi
GENES TO CELLS Vol. 5 No. 7 p. 571-581 2000/07 Research paper (scientific journal)
Phosphorylation of adducin by Rho-kinase plays a crucial role in cell motility
Yuko Fukata, Noriko Oshiro, Nagatoki Kinoshita, Yoji Kawano, Yoichiro Matsuoka, Vann Bennett, Yoshiharu Matsuura, Kozo Kaibuchi
Journal of Cell Biology Vol. 145 No. 2 p. 347-361 2000/06 Research paper (scientific journal)
GSK-3 beta-dependent phosphorylation of adenomatous polyposis coli gene product can be modulated by beta-catenin and protein phosphatase 2A complexed with Axin
S Ikeda, M Kishida, Y Matsuura, H Usui, A Kikuchi
ONCOGENE Vol. 19 No. 4 p. 537-545 2000/01 Research paper (scientific journal)
Cell adhesion and Rho small GTPases
M Fukata, M Nakagawa, S Kuroda, K Kaibuchi
JOURNAL OF CELL SCIENCE Vol. 112 No. 24 p. 4491-4500 1999/12
Regulation of cadherin-mediated cell-cell adhesion by the Rho family GTPases
K Kaibuchi, S Kuroda, M Fukata, M Nakagawa
CURRENT OPINION IN CELL BIOLOGY Vol. 11 No. 5 p. 591-596 1999/10
IκBαとβ-cateninの分解に関与するユビキチン化酵素複合体SCFFWD1
畠山鎮次, 中山啓子, 中野裕康, 奥村康, 菊池章, 小野江和則, 中山敬一
日本免疫学会総会・学術集会記録 Vol. 29 p. 104-104 1999/10 Research paper (scientific journal)
Cdc42, Rac1, and their effector IQGAP1 as molecular switches for cadherin-mediated cell-cell adhesion
S Kuroda, M Fukata, M Nakagawa, K Kaibuchi
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Vol. 262 No. 1 p. 1-6 1999/08 Research paper (scientific journal)
β-カテニンのユビキチン化に関わる分子FWD1の同定と機能解析
北川雅敏, 畠山鎮次, 菊池章, 中山啓子, 中山敬一
日本癌学会58回総会記事 p. 79-79 1999/08 Research paper (scientific journal)
NMR study of the MPH domain of the human EBIN protein
Koshiba S., Kigawa T., Kikuchi A., Yokoyama S.
Seibutsu Butsuri Vol. 39 1999
Publisher: The Biophysical Society of Japan General Incorporated Association
Double-Mutant Analysis of the Interaction of Ras with the Ras-Binding Domain of RGL
Shirouzu M., Hashimoto K., Kikuchi A., Yokoyama S.
Seibutsu Butsuri Vol. 39 1999
Publisher: The Biophysical Society of Japan General Incorporated Association
Localization of the gene coding for ROCK II Rho kinase on human chromosome 2p24
N Takahashi, H Tuiki, H Saya, K Kaibuchi
GENOMICS Vol. 55 No. 2 p. 235-237 1999/01 Research paper (scientific journal)
Domain- and site-specific phosphorylation of bovine NF-L by Rho-associated kinase
Hashimoto R, Nakamura Y, Goto H, Wada Y, Sakoda S, Kaibuchi K, Inagaki M, Takeda M
Biochem Biophys Res Commun Vol. 245 No. 2 p. 407-411 1998/04
Regulation of the association of adducin with actin filaments by Rho-associated kinase (Rho-kinase) and myosin phosphatase
K Kimura, Y Fukata, Y Matsuoka, Bennett, V, Y Matsuura, K Okawa, A Iwamatsu, K Kaibuchi
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 273 No. 10 p. 5542-5548 1998/03 Research paper (scientific journal)
Regulation of cell-cell adhesion of MDCK cells by Cdc42 and Rac1 small GTPases
S Kuroda, M Fukata, K Fujii, T Nakamura, Izawa, I, K Kaibuchi
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Vol. 240 No. 2 p. 430-435 1997/11 Research paper (scientific journal)
RalGDSを介するRasの新しい細胞内情情報伝達機構の解析 (助成研究報告)
菊池 章, 岸田 昭世
神戸大学医学部神緑会学術誌 Vol. 13 p. 139-143 1997/08
Publisher: 神戸大学
Purification and properties of Rab3A
Kikuchi A, Nakanishi H, Takai Y
Methods in Enzymology Vol. 257 No. C p. 57-70 1995
DIFFERENT FUNCTIONS OF SMG GDP DISSOCIATION STIMULATOR AND MAMMALIAN COUNTERPART OF YEAST CDC25
H NAKANISHI, K KAIBUCHI, S ORITA, N UENO, Y TAKAI
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 269 No. 21 p. 15085-15091 1994/05 Research paper (scientific journal)
KINETIC-PROPERTIES OF ASH/GRB2-INTERACTING GDP/GTP EXCHANGE PROTEIN
H NAKANISHI, S ORITA, K KAIBUCHI, K MIURA, H MIKI, T TAKENAWA, Y TAKAI
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Vol. 198 No. 3 p. 1255-1261 1994/02 Research paper (scientific journal)
SIGNALING MOLECULES THAT MEDIATE THE ACTION OF FGF
SD DEMO, A KIKUCHI, KG PETERS, AM MACNICOL, AJ MUSLIN, LT WILLIAMS
MOLECULAR AND CELLULAR BASIS FOR CELL TO CELL INTERACTION: ITS SIGNIFICANCE IN CANCER p. 243-249 1994 Research paper (international conference proceedings)
REGULATORS OF SMALL GTPASES
Y TAKAI, K KAIBUCHI, A KIKUCHI, T SASAKI, H SHIRATAKI
GTPASE SUPERFAMILY Vol. 176 p. 128-138 1993 Research paper (scientific journal)
S-9-3 the Small G Protein Superfamily - Possible Functions and Modes of Action
K. Kaibuchi, A. Kikuchi, M. Kawata, Y. Takai
Journal of Nutritional Science and Vitaminology Vol. 38 p. 275-278 1992 Research paper (scientific journal)
TRANSFORMING AND C-FOS PROMOTER ENHANCER-STIMULATING ACTIVITIES OF A GDP GTP EXCHANGE PROTEIN FOR SMALL GTP-BINDING PROTEINS
Y TAKAI, K KAIBUCHI, A KIKUCHI, M KAWATA, T SASAKI, T YAMAMOTO
MULTISTAGE CARCINOGENESIS Vol. 22 p. 197-204 1992 Research paper (international conference proceedings)
FUNCTIONS AND MODES OF ACTIONS OF SMG P21, A RAS P21-LIKE SMALL GTP-BINDING PROTEIN, IN SIGNAL TRANSDUCTION
Y TAKAI, K KAIBUCHI, A KIKUCHI, M KAWATA
STATUS OF DIFFERENTATION THERAPY OF CANCER, VOL 2 Vol. 82 p. 177-184 1991 Research paper (international conference proceedings)
DIRECT EVIDENCE FOR INVOLVEMENT OF A GUANINE NUCLEOTIDE-BINDING PROTEIN IN CHEMOTACTIC PEPTIDE-STIMULATED FORMATION OF INOSITOL BISPHOSPHATE AND TRISPHOSPHATE IN DIFFERENTIATED HUMAN-LEUKEMIC (HL-60) CELLS - RECONSTITUTION WITH GI OR GO OF THE PLASMA-MEMBRANES ADP-RIBOSYLATED BY PERTUSSIS TOXINT
A KIKUCHI, O KOZAWA, K KAIBUCHI, T KATADA, M UI, Y TAKAI
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 261 No. 25 p. 1558-1562 1986/09 Research paper (scientific journal)
がん病態における転写制御の理解と新規抗がん剤開発
Akira Kikuchi
2024/11
An analysis of DKK1-CKAP4 signaling as prognostic factors and potential therapeutic target of hepatocellular carcinoma
The 83rd Annual Meeting of the Japanese Cancer Association 2024/09
Hypoxia-induced Wnt5a-secreting fibroblasts promote colon cancer cell proliferation
Akikazu Harada, Akira kikuchi
The 83rd Annual Meeting of the Japanese Cancer Association 2024/09
Hypoxia-Induced Wnt5a expression in fibroblasts enhances colon cancer progression
Akira Kikuchi
2024/09
腺組織におけるWntシグナル誘導性のAQP3陽性扁平円柱皮前駆細胞の同定
p. 13-14 2024/07
A novel target for liver cancer therapy
2024/05
Oncogenic Transcription Difference between Wnt Signal-Activated Hepatocellular Carcinoma and Colorectal Carcinoma
Akira Kikuchi
Gordon Research Conference focused on Wnt Signaling 2023
大腸がんにおける腫瘍環境特異的がん関連線維芽細胞の実体とその制御
原田昭和, 菊池章
第82回日本癌学会学術総会 2023
Role of GREB1 isoform 4 in malignant melanoma formation and its application to cancer therapy
新澤康英, 松本真司, 佐田遼太, 原田昭和, 種村篤, 横井一範, 二村圭祐, 伊川正人, 曽我朋義, 菊池章
日本分子生物学会年会プログラム・要旨集(Web) Vol. 46th 2023
Wntシグナル経路による細胞機能制御の新展開 DKK1受容体CKPA4による細胞応答制御
山本 英樹, 佐田 遼太, 菊池 章
日本生化学会大会プログラム・講演要旨集 Vol. 94回 p. [3S06m-01] 2021/11
Publisher: (公社)日本生化学会膵がん・食道扁平上皮がんにおけるDKK1とFOXM1のポジティブフィードバック発現制御を介した腫瘍増殖促進メカニズムの解析
佐田 遼太, 木村 公一, 高田 直季, 山本 英樹, 菊池 章
日本生化学会大会プログラム・講演要旨集 Vol. 94回 p. [1T14e-744)] 2021/11
Publisher: (公社)日本生化学会Wnt標的遺伝子GREB1の組織特異的発現制御と肝細胞がんの増殖制御機構
松本 真司, 瀬田 みなみ, 福本 巧, 菊池 章
日本生化学会大会プログラム・講演要旨集 Vol. 94回 p. [1T14e-767)] 2021/11
Publisher: (公社)日本生化学会膵がん・食道扁平上皮がんにおけるDKK1とFOXM1のポジティブフィードバック発現制御を介した腫瘍増殖促進メカニズムの解析
佐田 遼太, 木村 公一, 高田 直季, 山本 英樹, 菊池 章
日本生化学会大会プログラム・講演要旨集 Vol. 94回 p. [P-06)] 2021/11
Publisher: (公社)日本生化学会肺がんにおけるDKK1-CKAP4シグナルと治療標的としての可能性
名越 章裕, 佐田 遼太, 木村 公一, 山本 英樹, 菊池 章
日本生化学会大会プログラム・講演要旨集 Vol. 94回 p. [P-745] 2021/11
Publisher: (公社)日本生化学会DKK1-CKAP4シグナルは肝癌の予後不良因子であり、CKAP4は新たな治療標的となりうる
井口 浩輔, 権 英寿, 木村 公一, 松本 真司, 福本 巧, 菊池 章
日本生化学会大会プログラム・講演要旨集 Vol. 94回 p. [P-758] 2021/11
Publisher: (公社)日本生化学会Wnt標的遺伝子GREB1の組織特異的発現制御と肝細胞がんの増殖制御機構
松本 真司, 瀬田 みなみ, 福本 巧, 菊池 章
日本生化学会大会プログラム・講演要旨集 Vol. 94回 p. [P-07)] 2021/11
Publisher: (公社)日本生化学会RAS下流のエフェクター分子ARL4Cを標的とした膵癌の浸潤転移の制御
原田 昭和, 松本 真司, 菊池 章
日本癌学会総会記事 Vol. 80回 p. [J10-2] 2021/09
Publisher: (一社)日本癌学会DKK1受容体CKPA4による細胞応答制御
山本英樹, 山本英樹, 佐田遼太, 菊池章
日本生化学会大会(Web) Vol. 94th 2021
Wnt標的遺伝子GREB1の組織特異的発現制御と肝細胞がんの増殖制御機構
松本真司, 瀬田みなみ, 福本巧, 菊池章
日本生化学会大会(Web) Vol. 94th 2021
膵がん・食道扁平上皮がんにおけるDKK1とFOXM1のポジティブフィードバック発現制御を介した腫瘍増殖促進メカニズムの解析
佐田遼太, 木村公一, 高田直季, 山本英樹, 菊池章
日本生化学会大会(Web) Vol. 94th 2021
肺がんにおけるDKK1-CKAP4シグナルと治療標的としての可能性
名越章裕, 佐田遼太, 木村公一, 山本英樹, 菊池章
日本生化学会大会(Web) Vol. 94th 2021
DKK1-CKAP4シグナルは肝癌の予後不良因子であり,CKAP4は新たな治療標的となりうる
井口浩輔, 井口浩輔, 権英寿, 木村公一, 松本真司, 福本巧, 菊池章
日本生化学会大会(Web) Vol. 94th 2021
Identification of the fibroblast subsets expressing Wnt5a in AOM/DSS model of colitis-associated colorectal cancer
原田武志, 原田昭和, 香山尚子, 佐藤朗, 菊池章
日本分子生物学会年会プログラム・要旨集(Web) Vol. 44th 2021
GREB1 isoform 4 stimulates cell proliferation of malignant melanoma via pyrimidine synthesis
新澤康英, 松本真司, 種村篤, 横井一範, 藤本学, 二村圭祐, 曽我朋義, 菊池章
日本分子生物学会年会プログラム・要旨集(Web) Vol. 44th 2021
RAS下流のエフェクター分子ARL4Cを標的とした膵癌の浸潤転移の制御
原田昭和, 松本真司, 菊池章
日本癌学会学術総会抄録集(Web) Vol. 80th 2021
マウス尿道形成過程における新たなWnt5aの機能
鈴木堅太郎, アルカンタラ メリッサ, アルビン アセベド, 坂本裕樹, 西田満, 南康博, 菊池章, 山田源
日本先天異常学会学術集会プログラム・抄録集 Vol. 61st (CD-ROM) 2021
RAS下流のエフェクター分子であるARL4Cの浸潤突起先端部への局在が膵癌の浸潤転移を制御する
原田 昭和, 松本 真司, 菊池 章
日本癌学会総会記事 Vol. 79回 p. OJ10-3 2020/10
Publisher: (一社)日本癌学会DKK1-CKAP4シグナルは肝癌の予後不良因子であり、CKAP4は新たな治療標的となりうる
井口 浩輔, 権 英寿, 木村 公一, 松本 真司, 福本 巧, 菊池 章
日本癌学会総会記事 Vol. 79回 p. OJ14-1 2020/10
Publisher: (一社)日本癌学会分子発がん研究:その足跡と未来(24年の歩み) Wntシグナルと分子標的治療
菊池 章
日本癌学会総会記事 Vol. 79回 p. CS1-5 2020/10
Publisher: (一社)日本癌学会大腸がんの診断・治療と発がん研究における新しい知見 炎症を伴った大腸がんにおけるWnt5aシグナルの役割
菊池 章
日本癌学会総会記事 Vol. 79回 p. SST4-4 2020/10
Publisher: (一社)日本癌学会肝芽腫におけるWntシグナル関連新規創薬標的GREB1の同定と核酸医薬の開発
山道 拓, 松本 真司, 奥山 宏臣, 菊池 章
日本小児血液・がん学会雑誌 Vol. 57 No. 2 p. 116-120 2020/09
Publisher: (一社)日本小児血液・がん学会Dickkopf1とFOXM1のポジティブフィードバックループは膵臓癌と食道癌の増殖と関連している(The Dickkopf1 and FOXM1 positive feedback loop is associated with tumor growth of pancreatic and esophageal cancer)
佐田 遼太, 高田 直季, 木村 公一, 菊池 章
日本生化学会大会プログラム・講演要旨集 Vol. 93回 p. [2Z08-544)] 2020/09
Publisher: (公社)日本生化学会肝細胞がんにおけるWnt標的遺伝子GREB1の発現と細胞増殖制御
瀬田 みなみ, 松本 真司, 福本 巧, 菊池 章
日本生化学会大会プログラム・講演要旨集 Vol. 93回 p. [2Z08-552)] 2020/09
Publisher: (公社)日本生化学会サンドイッチELISA法を用いた肺がん患者における血清CKAP4タンパク濃度の測定
名越 章裕, 佐田 遼太, 木村 公一, 山本 英樹, 菊池 章
日本生化学会大会プログラム・講演要旨集 Vol. 93回 p. [2Z08-613)] 2020/09
Publisher: (公社)日本生化学会グルカゴンの線維形成中のグルカゴン含有リン脂質二重膜の形態的変化の31Pと13Cを用いた解明(Morphological changes of glucagon-phospholipid bilayers during fibril formation of glucagon as revealed by 31P and 13C solid-state NMR)
内藤 晶, 羽矢 和未, 槇野 義輝, 菊池 章恵[木下], 川村 出
日本生化学会大会プログラム・講演要旨集 Vol. 93回 p. [P-177] 2020/09
Publisher: (公社)日本生化学会パルミトイル化CKAP4はVDAC2を介してミトコンドリア機能を制御する
原田 武志, 佐田 遼太, 大杉 祥仁, 松本 真司, 菊池 章
日本生化学会大会プログラム・講演要旨集 Vol. 93回 p. [P-296] 2020/09
Publisher: (公社)日本生化学会アネキシンA2によるDKK1受容体CKAP4の細胞膜への輸送制御
山本 英樹, 佐田 遼太, 菊池 章
日本生化学会大会プログラム・講演要旨集 Vol. 93回 p. [P-318] 2020/09
Publisher: (公社)日本生化学会悪性黒色腫におけるGREB1 isoform 4の発現機構解析と治療への応用
新沢 康英, 松本 真司, 種村 篤, 藤本 学, 菊池 章
日本生化学会大会プログラム・講演要旨集 Vol. 93回 p. [P-549] 2020/09
Publisher: (公社)日本生化学会Wntシグナル標的遺伝子GREB1によるTGFβシグナルの抑制を介した肝芽腫形成の制御
松本 真司, 山道 拓, 新沢 康英, 奥山 宏臣, 菊池 章
日本生化学会大会プログラム・講演要旨集 Vol. 93回 p. [P-551] 2020/09
Publisher: (公社)日本生化学会History and Perspective of Wnt Signaling Research~Footprints and Future~
菊池章
生化学 Vol. 92 No. 4 p. 498-516 2020/08
Publisher: (公社)日本生化学会
Wnt5a signaling and Colitis-associated tumor formation
菊池章
日本癌学会学術総会抄録集(Web) Vol. 79th 2020
Wnt signaling and molecular target therapy
菊池章
日本癌学会学術総会抄録集(Web) Vol. 79th 2020
History and Perspective of Wnt Signaling Research~Footprints and Future~
菊池章
生化学 Vol. 92 No. 4 2020
上皮形態形成研究を基盤とした新規抗がん剤開発
菊池章, 松本真司, 佐田僚太
膵臓(Web) Vol. 35 No. 3 2020
GREB1, a novel therapeutic target of Wnt signaling, promotes the development of hepatoblastoma by suppressing TGFβ signaling
山道拓, 山道拓, 松本真司, 奥山宏臣, 菊池章
日本小児血液・がん学会雑誌(Web) Vol. 57 No. 2 2020
DKK1受容体CKAP4のパルミチン酸化を介したシグナル制御機構
佐田 遼太, 木村 公一, 山本 英樹, 菊池 章
第42回日本分子生物学会年会 2019/12
DKK1-CKAP4シグナルと転写因子FOXM1のpositive feedback loop形成機構
高田 直季, 木村 公一, 菊池 章
第42回日本分子生物学会年会 2019/12
WntシグナルはTGFβシグナルを抑制することにより肝芽腫の腫瘍形成を促進する(A novel therapeutic target of Wnt signaling promotes the development of hepatoblastoma by suppressing TGFβ signaling)
山道 拓, 松本 真司, 奥山 宏臣, 菊池 章
日本癌学会総会記事 Vol. 78回 p. E-1055 2019/09
Publisher: (一社)日本癌学会膵癌細胞の腫瘍浸潤におけるArl4c-IQGAP1の相互作用(Roles of Arl4c-IQGAP1 interaction in tumor invasion of pancreatic cancer cells)
原田 昭和, 松本 真司, 菊池 章
日本癌学会総会記事 Vol. 78回 p. J-2009 2019/09
Publisher: (一社)日本癌学会DKK1新規受容体CKAP4は膵臓癌由来のエクソソームのバイオマーカーとがん治療の分子標的になる(CKAP4, a DKK1 receptor, is a biomarker in exosomes derived from pancreatic cancer and a molecular target for therapy)
山本 英樹, 木村 公一, 菊池 章
日本癌学会総会記事 Vol. 78回 p. P-2085 2019/09
Publisher: (一社)日本癌学会Arl4cを標的とした新規肺腺癌治療薬の開発(Development of a novel therapeutic agent for lung adenocarcinoma targeting Arl4c)
木村 賢二, 松本 真司, 新谷 康, 菊池 章
日本癌学会総会記事 Vol. 78回 p. P-3120 2019/09
Publisher: (一社)日本癌学会固体13C-NMRによる脂質膜存在下でのグルカゴンの線維形成機構の解析
内藤 晶, 山根 衣寿美, 百瀬 綾乃, 藤田 英樹, 吉本 瑛梨, 菊池 章江[木下], 川村 出
日本生化学会大会プログラム・講演要旨集 Vol. 92回 p. [1T14m-02] 2019/09
Publisher: (公社)日本生化学会細胞・組織動態解析と数理モデルで解く形態形成の原理 オルガノイドと数理モデルで迫る形態形成の仕組み
麓 勝己, 今村 寿子, 隅山 健太, 吉村 成弘, 菊池 章
日本生化学会大会プログラム・講演要旨集 Vol. 92回 p. [2S15a-04] 2019/09
Publisher: (公社)日本生化学会肝腫瘍に対するARL4Cを標的としたアンチセンス核酸を用いた新規がん治療法の開発
原田 武志, 松本 真司, 廣田 傑, 木村 公一, 藤井 慎介, 菊池 章
日本生化学会大会プログラム・講演要旨集 Vol. 92回 p. [2P-284] 2019/09
Publisher: (公社)日本生化学会新規Wntシグナル標的遺伝子によるTGFβシグナルの抑制を介した肝芽腫形成の制御
松本 真司, 山道 拓, 新沢 康英, 奥山 宏臣, 菊池 章
日本生化学会大会プログラム・講演要旨集 Vol. 92回 p. [3T16e-03] 2019/09
Publisher: (公社)日本生化学会DKK1受容体であるCKAP4とLRP6の動的パルミチン酸化は細胞膜マイクロドメイン局在を誘導しDKK1シグナルを制御する(Dynamic palmitoylation determines membrane microdomain localization of two DKK1 receptors CKAP4 and LRP6, and regulates DKK1 signaling)
山本 英樹, 佐田 遼太, 木村 公一, 菊池 章
日本生化学会大会プログラム・講演要旨集 Vol. 92回 p. [3P-198] 2019/09
Publisher: (公社)日本生化学会肝腫瘍に対するARL4Cを標的としたアンチセンス核酸を用いた新規がん治療法の開発
原田 武志, 松本 真司, 廣田 傑, 木村 公一, 藤井 慎介, 菊池 章
日本生化学会大会プログラム・講演要旨集 Vol. 92回 p. [2P-284] 2019/09
Publisher: (公社)日本生化学会DKK1 signal-dependent cellular functions through two receptors, LRP6 and CKAP4.
2019/06
Arl4cを標的としたAntisense oligonucleotidesのIn vitroでの効果
木村賢二, 松本真司, 福井絵里子, 狩野孝, 大瀬尚子, 舟木壮一郎, 南正人, 新谷康, 菊池章
日本胸部外科学会定期学術集会(Web) Vol. 72nd 2019
Wnt/β-cateninシグナルの新規標的遺伝子GREB1は,TGFβシグナルの抑制を介して肝芽種形成を促進する
新沢康英, 松本真司, 山道拓, 山道拓, 笠原勇矢, 野島聡, 小玉尚宏, 小比賀聡, 竹原徹郎, 森井英一, 奥山宏臣, 菊池章
日本分子生物学会年会プログラム・要旨集(Web) Vol. 42nd 2019
CKAP4-VDAC2相互作用によるミトコンドリア機能の制御
原田武志, 松本真司, 大杉祥仁, 菊池章
日本分子生物学会年会プログラム・要旨集(Web) Vol. 42nd 2019
The DKK1-CKAP4 signaling pathway as a novel therapeutic target for cancers.
Kimura H, Fumoto K, Kikuchi A
Australia Japan Medical Research Symposium 2018/09
がん特性の解明に迫るシグナル伝達研究 新規がんシグナルDickkopf1-CKAP4経路は、がん治療のための分子標的となる(Signal transduction analysis for cancer profiling The Dickkopf1-CKAP4 pathway, a novel cancer signaling, represents molecular targets for cancer therapy)
菊池 章, 木村 公一, 麓 勝己
日本癌学会総会記事 Vol. 77回 p. 1768-1768 2018/09
Publisher: 日本癌学会DKK1の新規受容体であるCKAP4のエクソソームへの移行機構の解析
木村 公一, 菊池 章
日本生化学会大会プログラム・講演要旨集 Vol. 91回 p. [1T13e-162)] 2018/09
Publisher: (公社)日本生化学会CKAP4の動的なパルミチン酸化修飾は癌細胞の膜マイクロドメイン形成と増殖シグナル伝達活性を調節する(Dynamic palmitoylation regulates membrane microdomain localization and cancer cell proliferative signaling activity of CKAP4)
佐田 遼太, 木村 公一, 山本 英樹, 菊池 章
日本生化学会大会プログラム・講演要旨集 Vol. 91回 p. [3T11m-095)] 2018/09
Publisher: (公社)日本生化学会Arl4cとIQGAP1の相互作用による膵がん細胞の増殖制御機構
赤間俊之, 松本真司, 原田昭和, 庄嶋健作, 菊池章
日本生化学会大会(Web) Vol. 91st 2018
唾液腺におけるWntシグナル依存的新規前駆細胞の同定と機能解析
松本真司, 廣田傑, 廣田傑, 菊池章
日本生化学会大会(Web) Vol. 91st 2018
小胞体-ミトコンドリア連携ゾーンにおけるII型膜タンパク質CKAP4の機能解析
原田武志, 大杉祥仁, 松本真司, 菊池章
日本生化学会大会(Web) Vol. 91st 2018
唾液腺におけるWntシグナル依存性新規前駆細胞の同定と機能解析
松本真司, 廣田傑, 廣田傑, 菊池章
Journal of Oral Biosciences Supplement (Web) Vol. 2018 2018
DickkopfファミリーによるCKAP4を介したがん細胞増殖調節機構
梶原 千裕, 麓 勝巳, 木村 公一, 菊池 章
生命科学系学会合同年次大会 Vol. 2017年度 p. [1P-1007] 2017/12
Publisher: 生命科学系学会合同年次大会運営事務局CKAP4の脂質修飾を介する機能制御
佐田 遼太, 木村 公一, 麓 勝己, 山本 英樹, 菊池 章
生命科学系学会合同年次大会 Vol. 2017年度 p. [4P1T25-0164)] 2017/12
Publisher: 生命科学系学会合同年次大会運営事務局Wnt Signaling Induces Factor X to Promote Tumorigenesis of Hepatoblastoma
Taku Yamamichi, Shinji Matsumoto, Akira Kikuchi, Hiroomi Okuyama
PEDIATRIC BLOOD & CANCER Vol. 64 p. S64-S64 2017/11 Research paper, summary (international conference)
がん分子標的治療薬の分子基盤と臨床応用 DKK1の新規受容体CKAP4を標的とする抗がん剤開発
菊池 章, 木村 公一, 麓 勝己, 大杉 祥仁
日本癌学会総会記事 Vol. 76回 p. S5-1 2017/09
Publisher: 日本癌学会食道扁平上皮癌の新規治療標的であるDKK1-CKAP4シグナル
木村 公一, 新野 直樹, 佐田 遼太, 麓 勝己, 菊池 章
日本癌学会総会記事 Vol. 76回 p. J-2059 2017/09
Publisher: 日本癌学会Wnt5a-Ror2シグナルによる骨吸収活性調節の病態モデルにおける役割
上原 俊介, 山下 照仁, 中村 貴, 加藤 茂明, 宇田川 信之, 高橋 直之, 小林 泰浩, 西田 満, 南 康博, 向井 秀幸, 菊池 章
日本骨代謝学会学術集会プログラム抄録集 Vol. 35回 p. 158-158 2017/07
Publisher: (一社)日本骨代謝学会CKAP4の翻訳後修飾を介する機能制御
佐田遼太, 木村公一, 麓勝己, 菊池章
第64回日本生化学会 近畿支部例会 2017/05
膵癌の新規治療標的であるDkk1新規受容体CKAP4
木村 公一, 麓 勝己, 庄島 健作, 大杉 祥仁, 菊池 章
膵臓 Vol. 32 No. 3 p. 502-502 2017/05
Publisher: 日本膵臓学会ヒト肺腺癌および肺扁平上皮癌におけるArl4cの発現はがん形成を促進する
藤井慎介, 松本真司, 清島保, 菊池章
日本病理学会会誌 Vol. 106 No. 1 2017
LDLによるLRP6のエンドサイトーシス経路とNPC1L1の細胞内局在の制御機構
山本英樹, 梅田大介, 松本真司, 菊池章
日本生化学会大会(Web) Vol. 90th 2017
腸管炎症関連疾患におけるWnt5aの機能解析
前原奈都美, 佐藤朗, 麓勝己, 菊池章
日本生化学会大会(Web) Vol. 90th 2017
Wnt5b含有エクソソームは癌細胞の増殖及び運動能を亢進させる
原田武志, 山本英樹, 菊池章
日本生化学会大会(Web) Vol. 90th 2017
Wnt/Rasシグナル標的因子Arl4cの膵癌における機能
松本真司, 赤間俊之, 庄嶋健作, 菊池章
日本生化学会大会(Web) Vol. 90th 2017
Wntシグナルによる頂端膜収縮の調節は肺分岐構造と肺胞形成を制御する
麓勝己, 今村寿子, 菊池章
日本生化学会大会(Web) Vol. 90th 2017
成体唾液腺におけるWntシグナル応答細胞の同定と機能解析
廣田傑, 廣田傑, 松本真司, 菊池章
日本生化学会大会(Web) Vol. 90th 2017
新規癌治療標的であるDkk1-CKAP4シグナル
木村 公一, 麓 勝己, 庄嶋 健作, 大杉 祥仁, 菊池 章
日本癌学会総会記事 Vol. 75回 p. IS2-5 2016/10
Publisher: 日本癌学会WntシグナルにおけるFrizzled受容体の活性化機構
山本英樹, 菊池章
医学のあゆみ Vol. 256 No. 5 2016/01/30
Activation mechanism of Frizzled receptor in Wnt signaling
山本 英樹, 菊池 章
医学のあゆみ Vol. 256 No. 5 p. 421-429 2016/01/30
Publisher: 医歯薬出版
低分子量Gタンパク質Arl4cによる上皮の形づくりと発がんの制御
松本真司, 藤井慎介, 原田武志, 菊池章
日本生化学会大会(Web) Vol. 89th 2016
肝細胞におけるLDLによるLRP6の異なるエンドサイトーシス経路の制御機構
山本英樹, 梅田大介, 松本真司, 菊池章
日本生化学会大会(Web) Vol. 89th 2016
ヒト大腸癌,肺腺癌および肺扁平上皮癌におけるArl4cの発現はがん形成を促進する
藤井慎介, 松本真司, 清島保, 菊池章
日本病理学会会誌 Vol. 105 No. 2 2016
増殖因子シグナルによる上皮形態形成の分子機構とその破綻による腫瘍形成
菊池章, 松本真司, 藤井慎介
日本細胞生物学会大会(Web) Vol. 68th 2016
エキソソーム上のWnt5bは細胞環境に応じて,がん細胞の増殖と運動を制御する
原田武志, 山本英樹, 菊池章
日本生化学会大会(Web) Vol. 89th 2016
WntとKITシグナルの活性化バランスによる唾液腺の形づくりと機能獲得過程の制御
松本真司, 栗本聖之, 藤井慎介, 菊池章
Journal of Oral Biosciences Supplement (Web) Vol. 2016 2016
Wnt5aシグナルは炎症を背景とした大腸がん形成に促進的に作用する
佐藤朗, 佐藤朗, 前原奈都美, 扇田久和, 菊池章
日本分子生物学会年会プログラム・要旨集(Web) Vol. 39th 2016
Wntシグナルによる頂端膜収縮の調節は肺分岐構造と肺胞形成を制御する
麓勝己, 今村(滝川)寿子, 菊池章
日本分子生物学会年会プログラム・要旨集(Web) Vol. 39th 2016
Wnt5a-Ror2シグナルによる腸管炎症の増悪機構の解析
佐藤 朗, 香山 尚子, 庄嶋 健作, 松本 真司, 小山 浩史, 南 康博, 野島 聡, 森井 英一, 本田 浩章, 竹田 潔, 菊池 章
日本生化学会大会・日本分子生物学会年会合同大会講演要旨集 Vol. 88回・38回 p. [1P0170]-[1P0170] 2015/12
Publisher: (公社)日本生化学会上皮管腔形成研究を基盤にしたがん治療のための新規標的分子の同定
菊池 章, 藤井 慎介, 木村 公一, 麓 勝巳, 松本 真司
日本癌学会総会記事 Vol. 74回 p. ML2-ML2 2015/10
Publisher: 日本癌学会Dkk1新規受容体CKAP4は膵癌および肺癌の治療標的分子である
木村 公一, 麓 勝己, 菊池 章
日本癌学会総会記事 Vol. 74回 p. J-1295 2015/10
Publisher: 日本癌学会Wnt/β‐カテニンシグナルは唾液腺上皮の腺房分化を制御する
栗本聖之, 栗本聖之, 松本真司, 藤井慎介, 菊池章, 古郷幹彦
日本口腔科学会雑誌 Vol. 64 No. 2 2015/07/10
Wnt5aシグナル伝達―その異常のがんと炎症における意義―
菊池章, 山本英樹, 佐藤朗, 松本真司
日本整形外科学会雑誌 Vol. 89 No. 6 2015/06/05
Wnt3aとEGFシグナルによって発現するP2Y2Rは上皮管腔形成を制御する
井深奏司, 松本真司, 藤井慎介, 菊池章, 奥山宏臣
日本小児外科学会雑誌 Vol. 51 No. 3 p. 502-502 2015/05/25
Publisher: (一社)日本小児外科学会
ヒトがんにおける低分子量G蛋白質Arl4cの異常と機能
菊池章
上原記念生命科学財団研究報告集(CD-ROM) Vol. 29 2015
Greb1による尿管上皮管腔形成における細胞増殖制御機構の解析
山道拓, 松本真司, 菊池章
日本生化学会大会(Web) Vol. 88th 2015
Wnt5aの極性分泌による上皮細胞の内腔形成制御機構
山本英樹, 粟田ちひろ, 高尾敏文, 菊池章
日本生化学会大会(Web) Vol. 88th 2015
Wnt/β‐カテニンシグナルは終末部上皮の腺房化の調節を介して胎生期唾液腺の形態形成を制御する
松本真司, 栗本聖之, 藤井慎介, 菊池章
日本生化学会大会(Web) Vol. 88th 2015
Wnt5bの細胞外分泌機構とその生理機能の解析
原田武志, 山本英樹, 菊池章
日本生化学会大会(Web) Vol. 88th 2015
ヒトがんにおける低分子量G蛋白質Arl4cの異常と機能
菊池 章
上原記念生命科学財団研究報告集 Vol. 29 p. 1-5 2015
Publisher: 上原記念生命科学財団
がんと脂質 分子メカニズムへ 2.Wntの脂質修飾を標的にしたがん創薬
山本英樹, 菊池章
Lipid Vol. 25 No. 4 p. 384-390 2014/10/10
DKK1による細胞増殖調節機構
木村 公一, 麓 勝己, 菊池 章
日本生化学会大会プログラム・講演要旨集 Vol. 87回 p. [3P-323] 2014/10
Publisher: (公社)日本生化学会Wnt5a-Ror2シグナルによる腸管炎症の増悪機構の解析
佐藤 朗, 香山 尚子, 庄嶋 健作, 松本 真司, 小山 浩史, 南 康博, 野島 聡, 森井 英一, 本田 浩章, 竹田 潔, 菊池 章
日本生化学会大会プログラム・講演要旨集 Vol. 87回 p. [2T09p-07] 2014/10
Publisher: (公社)日本生化学会OP-056-5 大腸癌肝転移の予後因子としてのh-prune(OP-056 肝 転移性肝癌-2,一般演題,第114回日本外科学会定期学術集会)
橋本 昌和, 小林 剛, 田代 裕尊, 黒田 慎太郎, 楠部 潤子, 御厨 美洋, 菊池 章, 大段 秀樹
日本外科学会雑誌 Vol. 115 No. 2 p. 415-415 2014/03/05
Publisher: 一般社団法人日本外科学会
消化管の再生医療 In vitro実験系を用いた上皮管腔組織形成の分子基盤の確立
松本真司, 菊池章
G.I. Research Vol. 22 No. 5 2014
Wnt/β‐カテニンシグナルは外分泌腺上皮の分岐と導管形成を制御する
松本真司, 栗本聖之, 藤井慎介, 菊池章
日本生化学会大会(Web) Vol. 87th 2014
極性化された上皮細胞におけるWntとその受容体の輸送制御機構
山本英樹, 金岩知之, 粟田ちひろ, 高尾敏文, 菊池章
日本生化学会大会(Web) Vol. 87th 2014
Wnt/EGFシグナルにより発現するP2ry2は上皮管腔形態形成を制御する
井深奏司, 松本真司, 菊池章
日本生化学会大会(Web) Vol. 87th 2014
翻訳後修飾によるWnt5aの細胞外分泌の制御機構
杉本崇行, 山本英樹, 粟田ちひろ, 高尾敏文, 坂根洋, 菊池章
日本生化学会大会(Web) Vol. 87th 2014
Wntシグナルによる肺分岐形態形成制御機構
麓勝己, 金岩知之, 菊池章
日本生化学会大会(Web) Vol. 87th 2014
上皮細胞頂底極性制御におけるWntシグナル構成因子Dvlの役割
原田昭和, 麓勝己, 菊池章
日本生化学会大会(Web) Vol. 87th 2014
細胞接着の制御 Wnt 5aシグナルによる細胞の極性と遊走・接着の制御
松本真司, 菊池章
生体の科学 Vol. 64 No. 3 p. 226-231 2013/06/15
Publisher: (公財)金原一郎記念医学医療振興財団
Wntシグナルと骨 古典的Wntシグナルの情報伝達と細胞応答
菊池章
Clin Calcium Vol. 23 No. 6 p. 799-807 2013/05/28
Role of Wnt 5a signaling in the regulation of cell polarity, migration, and adhesion
松本 真司, 菊池 章
生体の科学 Vol. 64 No. 3 p. 226-231 2013/05
Publisher: 金原一郎記念医学医療振興財団 ; 1949-
Wnt協奏曲:新たな活性化機構と他の増殖・分化シグナルとの協調による形態形成 基礎の基礎 Wnt研究のこれまでとこれから~過去・現在・未来~
菊池章
細胞工学 Vol. 32 No. 4 p. 382-387 2013/03/22
Wnt協奏曲:新たな活性化機構と他の増殖・分化シグナルとの協調による形態形成【第1部:Wntシグナル活性化の新機軸】極性化上皮細胞におけるWntの分泌制御
山本英樹, 菊池章
細胞工学 Vol. 32 No. 4 p. 388-395 2013/03/22
Publisher: 学研メディカル秀潤社 ; 1982-
Wnt協奏曲:新たな活性化機構と他の増殖・分化シグナルとの協調による形態形成【第2部:Wntシグナルと幹細胞からの組織形態形成】Wntと増殖因子の協調的シグナルによる上皮管腔組織形成
松本真司, 菊池章
細胞工学 Vol. 32 No. 4 p. 435-441 2013/03/22
Publisher: 学研メディカル秀潤社 ; 1982-
Wntと細胞増殖シグナルの協調的作用による上皮管腔組織形成の分子機構
菊池章, 松本真司, 藤井慎介, 井深泰司
再生医療 Vol. 12 2013/02/28
Wnt5aシグナルは基底膜誘導性の単一細胞レベルでの頂底極性形成を制御する
権英寿, 麓勝己, 菊池章
日本生化学会大会(Web) Vol. 86th 2013
Wnt/β‐cateninシグナル経路は唾液腺上皮の発生を制御する
藤井慎介, 松本真司, 菊池章
日本分子生物学会年会プログラム・要旨集(Web) Vol. 36th 2013
Wnt/EGFシグナルによるP2ry2の発現は上皮管腔形態形成を制御する
井深奏司, 松本真司, 菊池章
日本分子生物学会年会プログラム・要旨集(Web) Vol. 36th 2013
肺分岐形態形成におけるWntシグナルによる分裂軸制御機構及び生理的意義
麓勝己, 菊池章
日本分子生物学会年会プログラム・要旨集(Web) Vol. 36th 2013
極性化された上皮細胞におけるWntの分泌制御機構
山本英樹, 花木英明, 辻本育子, 金岩知之, 粟田ちひろ, 高尾敏文, 菊池章
日本生化学会大会(Web) Vol. 86th 2013
Wnt5aノックアウトマウスにおける腸管炎症の抑制
佐藤朗, 庄嶋健作, 香山尚子, 小山浩史, 竹田潔, 菊池章
日本分子生物学会年会プログラム・要旨集(Web) Vol. 36th 2013
Regulation of Secretion of Wnts in Polarized Epithelial Cells
山本 英樹, 菊池 章
細胞工学 Vol. 32 No. 4 p. 388-395 2013
Publisher: 学研メディカル秀潤社 ; 1982-
Wnt Regulates Epithelial Tubular Structure in Cooperation with Growth Factor Signalling
松本 真司, 菊池 章
細胞工学 Vol. 32 No. 4 p. 435-441 2013
Publisher: 学研メディカル秀潤社 ; 1982-
Wntシグナル伝達経路で機能するDIXドメインを介した相互作用の構造生物学
勝谷拓也, 寺脇慎一, 柴田直樹, 山本英樹, FIEDLER Marc, BIENZ Mariann, 菊池章, 樋口芳樹
日本結晶学会年会講演要旨集 Vol. 2012 2012/10/25
細胞周期制御の新展開 新規細胞周期依存性RhoGAP「Celmobilin」によるヒト癌細胞の遊走と浸潤の制御(New aspect of cell cycle research and cancer A novel cell cycle-associated RhoGAP, Celmobilin, regulates cancer cell motility and invasion in human)
賀川 義規, 西川 恵三, 前田 栄, 松本 真司, 奥崎 大介, 三森 功士, 山本 浩文, 関本 貢嗣, 菊池 章, 石井 秀始, 土岐 祐一郎, 森 正樹, 石井 優
日本癌学会総会記事 Vol. 71回 p. 94-94 2012/08
Publisher: 日本癌学会シグナル伝達の破綻と疾患との連関 7.Wntシグナルの異常と消化器がん
菊池章, 松本真司
実験医学 Vol. 30 No. 5 p. 823-830 2012/03/25
Low-density lipoprotein receptor-related protein6の毛細胆管における局在とトランスサイトーシスに関する研究
梅田大介, 山本英樹, 松本真司, 菊池章
日本生化学会大会(Web) Vol. 85th 2012
Wnt5a: its signalling, functions and implication in diseases
A. Kikuchi, H. Yamamoto, A. Sato, S. Matsumoto
ACTA PHYSIOLOGICA Vol. 204 No. 1 p. 17-33 2012/01 Book review, literature introduction, etc.
Wnt5aシグナルによる細胞質分裂制御機構
麓勝己, 菊池浩二, 菊池章
日本分子生物学会年会プログラム・要旨集(Web) Vol. 35th 2012
Wnt5aノックアウトマウスにおける腸管炎症の抑制
佐藤朗, 庄嶋健作, 小山浩史, 菊池章
日本分子生物学会年会プログラム・要旨集(Web) Vol. 35th 2012
翻訳後修飾によるWnt11の機能発現の制御
山本英樹, 花木英明, 辻本育子, 粟田ちひろ, 高尾敏文, 菊池章
日本生化学会大会(Web) Vol. 85th 2012
Wnt/β‐cateninシグナルとEGFシグナルの協調による三次元基質内での上皮分岐管腔形成制御機構の解析
松本真司, 藤井慎介, 井深奏司, 菊池章
日本分子生物学会年会プログラム・要旨集(Web) Vol. 35th 2012
がんにおける分子標的としてのWnt5a
菊池章
がん研究分野の特性等を踏まえた支援活動合同公開シンポジウムプログラム・抄録集 平成24年 2012
3次元基底膜マトリックス誘導性の単一細胞レベルでの頂底極性形成におけるWnt5aシグナルの役割
権英寿, 麓勝己, 菊池章
日本生化学会大会(Web) Vol. 85th 2012
基底膜蛋白質Nidogen‐1はWnt3aと結合しWnt/βカテニン経路の活性化を促進する
藤井慎介, 松本真司, 佐藤祐哉, 下野知性, 関口清俊, 菊池章
日本生化学会大会(Web) Vol. 85th 2012
分裂期チェックポイント分子BUBR1は脊椎動物における繊毛形成を制御する
宮本達雄, PORAZINSKI Sean, WANG Huijia, 清水厚志, 梶井正, 菊池章, 古谷(清水)誠, 松浦伸也
日本放射線影響学会大会講演要旨集 Vol. 54th 2011/11/01
Wntシグナルによる上皮形態形成制御とその異常による病態
菊池章
日本内分泌学会雑誌 Vol. 87 No. 1 2011/04/01
基礎研究編:発癌から浸潤・転移に至るメカニズム解明 第1章 発癌シグナルの原因究明 2.Wntシグナルネットワークの異常と癌
菊池章, 佐藤朗, 松本真司
実験医学 Vol. 29 No. 2 p. 170-179 2011/02/01
Publisher: (株)羊土社
Wnt5a deficiency ameliorates the dextran sulfate sodium (DSS)-induced acute colitis.
SATO Akira, SHOJIMA Kensaku, KOYAMA Hirofumi, KIKUCHI Akira
日本分子生物学会年会プログラム・要旨集(Web) Vol. 34th 2011
Glypican‐4の脂質ラフトへの局在に依存したWntシグナル伝達の制御機構
坂根洋, 山本英樹, 松本真司, 佐藤朗, 菊池章
生化学 2011
翻訳後修飾によるWnt蛋白質の機能発現の制御
山本英樹, 粟田ちひろ, 高尾敏文, 岸田昭世, 岸田想子, 菊池章
生化学 2011
Wnt5a: Its signaling, cellular functions, and diseases
A. Kikuchi, H. Yamamoto, A. Sato, S. Matsumoto, H. Hanaki
DIFFERENTIATION Vol. 80 p. S15-S15 2010/11 Research paper, summary (international conference)
Wnt signaling pathways regulate epithelial polarity and morphogenesis
Shinji Matsumoto, Akira Kikuchi
DIFFERENTIATION Vol. 80 p. S21-S21 2010/11 Research paper, summary (international conference)
造血細胞におけるWnt5aの欠失はp210BCR/ABLによって引き起こされるCMLを増悪させる(Loss of Wnt5a in hematopoietic cells exacerbate Chronic Myelogenous Leukemia induced by p210BCR/ABL fusion protein)
稲垣 舞子, 小山 浩史, 菊池 章, 本田 浩章
日本癌学会総会記事 Vol. 69回 p. 113-113 2010/08
Publisher: 日本癌学会Wntシグナルと細胞応答 細胞周期制御におけるWntシグナルの役割
菊池浩二, 菊池章
医学のあゆみ Vol. 233 No. 10 p. 960-965 2010/06/05
Wntシグナルと細胞応答 Wntシグナル経路の多様性と選択的活性化
山本英樹, 菊池章
医学のあゆみ Vol. 233 No. 10 p. 948-954 2010/06/05
Publisher: 医歯薬出版
Selective activation of multiple Wnt signaling pathways
山本 英樹, 菊池 章
医学のあゆみ Vol. 233 No. 10 p. 948-954 2010/06/05
Publisher: 医歯薬出版
Signal Transduction and Cellular Functions through GSK-3
KIKUCHI Akira
Vol. 41 No. 2 p. 19S-20S 2010/03/31
Wnt5aによるDishevelled/Adenomatous polyposis coli複合体を介した細胞接着と細胞運動の制御
松本真司, 岡本哲治, 菊池章
組織培養研究 Vol. 29 No. 1 p. 80-80 2010/03/31
Publisher: 日本組織培養学会
Wnt‐5aはlaminin g2の発現を誘導し,胃癌細胞の浸潤を促進する
大上直秀, 菊池章, 安井弥
日本病理学会会誌 Vol. 99 No. 1 2010/03/26
β-catenin-independent Wnt signaling regulates cell migration, polarity, and morphogenesis
MATSUMOTO Shinji, OKAMOTO Tetsuji, KIKUCHI Akira
TISSUE CULTURE RESEARCH COMMUNICATIONS Vol. 28 No. 2 p. 117-128 2009/12/31
Publisher: 日本組織培養学会
造血幹細胞の自己複製におけるβカテニン非依存的Wntシグナルの役割
岡村敏志, 大江原淳, 山崎聡, 菊池章, 中内啓光, 依馬秀夫
臨床血液 Vol. 50 No. 9 2009/09/30
Wnt5aによるDishevelled/Adenomatous polyposis coli複合体を介した細胞接着と細胞運動の制御
松本真司, 菊池章
生化学 2009/09/25
DKK1によるLRP6のエンドサイトーシスを介するWntシグナル伝達の制御
坂根洋, 山本英樹, 菊池章
生化学 2009/09/25
Wntシグナルネットワークとその異常による病態
菊池章
生化学 Vol. 81 No. 9 p. 780-792 2009/09/25
Publisher: 日本生化学会
異なる受容体エンドサイトーシス経路を介するWntシグナル伝達の制御機構
山本英樹, 坂根洋, 菊池章
生化学 2009/09/25
Wntシグナル関連分子Dishevelledによる上皮極性・形態形成制御機構についての解析
松本真司, 菊池章, 岡本哲治
組織培養研究 Vol. 28 No. 1 p. 67-67 2009/03/31
Publisher: 日本組織培養学会
三次元培養法を用いたDishevelledによる分枝形態形成制御機構についての解析
松本真司, 松本真司, 菊池章, 岡本哲治
日本口腔科学会雑誌 Vol. 58 No. 4 2009
Axin-HIPK3複合体の解析
上田茂之, 岡本健吾, 藤原誠, 松本真司, 菊池浩二, 佐藤朗, 菊池章
日本分子生物学会年会講演要旨集 Vol. 32nd No. Vol.1 2009
Axin‐Testis derived transcript複合体の解析
上田茂之, 佐藤朗, 岡本健吾, 藤原誠, 松本真司, 菊池浩二, 小山浩史, 菊池章
日本分子生物学会年会講演要旨集 Vol. 32nd No. Vol.1 2009
.BETA.-catenin-independent Wnt signaling regulates cell migration, polarity, and morphogenesis
松本真司, 岡本哲治, 菊池章
組織培養研究 Vol. 28 No. 2/3/4 p. 117-128 (J-STAGE)-128 2009
Publisher: The Japanese Tissue Culture Association
Wnt5aにより活性化されるシグナルネットワークと消化管の発生分化の分子機構およびその異常による消化器癌の悪性化
菊池章
上原記念生命科学財団研究報告集(CD-ROM) Vol. 23 2009
Wntによるβカテニン非依存性経路の活性化とその異常による病態
菊池章, 山本英樹, 佐藤朗
蛋白質 核酸 酵素 Vol. 54 No. 1 p. 1-10 2009/01/01
Publisher: 共立出版
Activation of the β-catenin-independent pathway by Wnt and the diseases due to its abnormality
菊池 章, 山本 英樹, 佐藤 朗
Protein, nucleic acid and enzyme Vol. 54 No. 1 p. 1-10 2009/01
Publisher: 共立出版
三次元培養系を用いたWntシグナルによる上皮細胞の極性・形態形成制御機構についての解析
松本真司, 岡本哲治, 菊池章
日本口腔科学会雑誌 Vol. 57 No. 4 p. 463-463 2008/09/10
Publisher: (NPO)日本口腔科学会
TUMOR FORMATION DUE TO ABNORMALITIES IN THE beta-CATENIN-INDEPENDENT PATHWAY OF WNT SIGNALING
Akira Kikuchi, Hideki Yamamoto, Manabu Kurayoshi
ANTICANCER RESEARCH Vol. 28 No. 5C p. 3348-3349 2008/09 Research paper, summary (international conference)
Wnt‐5aによるTGF‐β依存性軟骨細胞分化の制御
中村光宏, 安達伸生, 出家正隆, 越智光夫, 菊池章
日本整形外科学会雑誌 Vol. 82 No. 8 2008/08/25
Wnt5a発現による胃癌の高度悪性化
山本英喜, 菊池章
日本臨床 Vol. 66 p. 143-147 2008/07/28
Publisher: 日本臨床社
三次元培養系を用いたWntシグナルによる上皮細胞の極性・形態形成制御機構についての解析
松本真司, 岡本哲治, 菊池章
組織培養研究 Vol. 27 No. 1 p. 62-62 2008/03/31
Publisher: 日本組織培養学会
3次元培養を用いたDishevelledによる細胞運動・形態形成制御機構の解析
松本真司, 麓勝己, 菊池章
生化学 2008
Wntシグナルによる細胞運動制御とその異常による癌の悪性化
菊池章
生化学 2008
コンディショナルノックアウトマウスによるマウスWnt5aの機能解析
小山浩史, 佐藤朗, 本田浩章, 菊池章
生化学 2008
Wnt5aによるWnt3a‐β‐catenin経路の新規抑制機構の解析
佐藤朗, 坂根洋, 小山浩史, 菊池章
生化学 2008
DKK1によるLRP6のエンドサイトーシスを介するWntシグナル伝達の制御
坂根洋, 山本英樹, 菊池章
生化学 2008
シグナル伝達 タンパク質間相互作用を介するWntシグナルの制御機構
菊池章
生体の科学 Vol. 58 No. 5 p. 404-406 2007/10/15
タンパク質間相互作用を介するWntシグナルの制御機構 (タンパク質間相互作用)
菊池 章
生体の科学 Vol. 58 No. 5 p. 404-406 2007/09
Publisher: 金原一郎記念医学医療振興財団
Wnt‐5aによるTGF‐β依存性軟骨細胞分化の制御
中村光宏, 安達伸生, 出家正隆, 越智光夫, 菊池章
日本整形外科学会雑誌 Vol. 81 No. 8 2007/08/25
Regulation of Wnt signalling by receptor-mediated endocytosis
Akira Kikuchi, Hideki Yamamoto
JOURNAL OF BIOCHEMISTRY Vol. 141 No. 4 p. 443-451 2007/04 Book review, literature introduction, etc.
High expression of h-prune in gastric cancer with gastric phenotype : expression of h-prune is associated with poor survival in gastric cancer
Naohide Oue, Akira Kikuchi, Wataru Yasui
CLINICAL & EXPERIMENTAL METASTASIS Vol. 24 No. 4 p. 291-291 2007 Research paper, summary (international conference)
SUMOとの結合を介する脱SUMO化酵素活性の制御
小山浩史, 井原基公, 庄嶋健作, 菊池章
生化学 2007
クラスリンを介するLRP6のエンドサイトーシスによるWntシグナル伝達の制御
坂根洋, 山本英樹, 菊池章
生化学 2007
Developmental stage-specific roles of Wnt/ss-catenin signaling in cardiomyogenesis
Atsuhiko T. Naito, Ichiro Shiojima, Hiroshi Akazawa, Akira Kikuchi, Issei Komuro
CIRCULATION Vol. 114 No. 18 p. 233-233 2006/10 Research paper, summary (international conference)
Wnt3aの機能における糖鎖修飾と脂質修飾の役割
米門秀行, 山本英樹, 千葉勉, 菊池章
日本癌学会学術総会記事 Vol. 65th 2006/08/28
カベオリンを介するLRP6のエンドサイトーシスによるWntシグナル伝達の制御
山本英樹, 米門秀行, 菊池章
日本癌学会学術総会記事 Vol. 65th 2006/08/28
Wnt‐5aによる細胞運動能の促進と胃癌の悪性化
菊池章
日本癌学会学術総会記事 Vol. 65th 2006/08/28
Wnt‐5aは接着斑ダイナミクスを制御することにより胃癌細胞における細胞運動を促進する
倉吉学, 大上直秀, 山本英樹, 岸田想子, 安井弥, 菊池章
日本癌学会学術総会記事 Vol. 65th 2006/08/28
ユビキチンとシグナル伝達 ユビキチン化を介するβカテニンの分解制御とその異常による発がんの分子機構 (ユビキチン-プロテアソーム系とオートファジー--作動機構と病態生理) -- (ユビキチン系の生理と病態)
菊池 章, 岸田 昭世
蛋白質核酸酵素 Vol. 51 No. 10 p. 1271-1276 2006/08
Publisher: 共立出版
Glycogen Synthase Kinase-3 (GSK-3)とhpruneによる細胞運動制御
小林 剛, 菊池 章, 安井 弥, 浅原 利正
日本外科学会雑誌 Vol. 107 No. 2 p. 608-608 2006/03/05
Publisher: 一般社団法人日本外科学会
翻訳後修飾によるWntシグナル伝達の制御と細胞応答
菊池章
日本分子生物学会年会講演要旨集 Vol. 28th 2005/11/25
受容体型チロシンキナーゼRor2によるWnt/PCP経路の制御とその細胞運動における役割
西田満, 野町昭, 可児修一, 菊池章, 南康博
日本分子生物学会年会講演要旨集 Vol. 28th 2005/11/25
シグナル伝達研究のフロンティア Wntシグナルによる多彩な細胞機能制御
菊池章
日本口腔科学会雑誌 Vol. 54 No. 4 p. 458-459 2005/09/10
Wnt受容体のエンドサイトーシスによるシグナル伝達の制御
山本英樹, 菊池章
日本癌学会学術総会記事 Vol. 64th 2005/08/15
HTLV‐1TaxによるWntシグナルの活性化
富田真理子, 菊池章, 秋山徹, 森直樹
日本癌学会学術総会記事 Vol. 64th p. 343-344 2005/08/15
翻訳後修飾によるWnt3aの機能制御
米門秀行, 山本英樹, 千葉勉, 菊池章
日本癌学会学術総会記事 Vol. 64th 2005/08/15
細胞のダイナミクスを制御する リン酸化シグナル リン酸化修飾を介するWntシグナルネットワークによる細胞応答
山本英樹, 日野真一郎, 菊池章
実験医学 Vol. 23 No. 13 p. 1993-1998 2005/08/01
Ror2-mediated cytoskeletal reorganization by differential regulation of Dishevelled proteins
Akira Nomachi, Michiru Nishita, Shuichi Kani, Akira Kikuchi, Akinori Yoda, Yasuhiro Minami
CELL STRUCTURE AND FUNCTION Vol. 30 p. 107-107 2005/06 Research paper, summary (international conference)
Wntシグナルネットワークによる多彩な細胞機能制御
菊池章, 岸田昭世, 山本英樹, 日野真一郎
組織培養研究 Vol. 24 No. 1 2005/03/31
Wntシグナルによる多彩な細胞機能制御
菊池章
日本細菌学雑誌 Vol. 60 No. 1 2005/02/25
蛋白質間相互作用に基づく蛋白質リン酸化酵素GSK-3のシグナル伝達の分子機構
菊池 章
三共生命科学研究振興財団研究報告集 Vol. 21 p. 38-45 2005
Publisher: 三共生命科学研究振興財団
ユビキチン化を介するβ-カテニンの分解制御とその異常による発癌 (第1土曜特集 ユビキチン研究の新展開--メカニズムから疾患研究へ) -- (病態生理編)
菊池 章
医学のあゆみ Vol. 211 No. 1 p. 59-65 2004/10/02
Publisher: 医歯薬出版
Wntシグナルの制御と発がん
菊池章
日本癌学会総会記事 Vol. 63rd 2004/08/25
エンドサイトーシスによるWntシグナル伝達の制御
山本英樹, 菊池章
日本癌学会総会記事 Vol. 63rd 2004/08/25
Regulation of transcription in the Wnt signaling pathway
山科敬太郎, 菊池章
蛋白質 核酸 酵素 Vol. 49 No. 10 p. 1421-1427 2004/08/01
Publisher: 共立出版
Tumor formation by genetic mutations of β-catenin, APC, and axin in the Wnt signaling pathway
Akira Kikuchi, Shosei Kishida, Hideki Yamamoto, Shin-Ichiro Hino
Gann Monographs on Cancer Research Vol. 52 p. 157-171 2004/07 Book review, literature introduction, etc.
Multiple Cellular Functions Regulated by Wnt Signal
菊池章
細胞工学 Vol. 23 No. 6 p. 634-636 2004/06
Publisher: 秀潤社
Regulation of Wnt Signaling Pathway by Endocytosis
山本英樹, 菊池章
細胞工学 Vol. 23 No. 6 p. 637-641 2004/06
Publisher: 秀潤社
β-カテニンの分解異常とがん (特集 蛋白質のユビキチン化と疾患) -- (疾患とユビキチン化)
菊池 章
現代医療 Vol. 36 No. 4 p. 968-976 2004/04
Publisher: 現代医療社
Wntシグナル構成因子Dvlに結合する新規蛋白質の同定とその機能解析
大下彰彦, 菊池章, 小林剛, 坂本敏行, 浅原利正
日本外科学会雑誌 Vol. 105 p. 479-479 2004/03/15
Publisher: 一般社団法人日本外科学会
Wntシグナルとがん
菊池章
月刊血液・腫よう科 Vol. 48 No. 2 p. 228-234 2004/02/28
タンパク質修飾・分解と細胞機能 β-カテニン分解の分子機構
日野真一郎, 菊池 章
実験医学 Vol. 22 No. 2 p. 219-225 2004/01
Alteration of Wnt Signaling Pathway and Carcinogenesis
小林剛, 日野真一郎, 菊池章
Biotherapy (Tokyo) Vol. 17 No. 6 p. 528-536 2003/11/30
SUMO化によるWntシグナル伝達の制御機構
山本英樹, 井原基公, 菊池章
日本分子生物学会年会プログラム・講演要旨集 Vol. 26th 2003/11/25
Wntシグナル伝達分子Dvlとシナプトタグミンの相互作用
上田こずえ, 岸田昭世, 大下彰彦, 福田光則, 御子柴克彦, 菊池章
日本分子生物学会年会プログラム・講演要旨集 Vol. 26th 2003/11/25
翻訳後修飾を介したWntシグナル伝達経路の制御機構
菊池章
日本分子生物学会年会プログラム・講演要旨集 Vol. 26th 2003/11/25
遺伝子機能からみた臓器特異的ヒト発がん Wntシグナル伝達経路におけるβ‐カテニンの機能制御とその異常による発がん
菊池章, 岸田昭世, 山本英樹, 日野真一郎
日本癌学会総会記事 Vol. 62nd 2003/08/25
Wntシグナルと消化器疾患 Wntシグナルをつかさどる分子群
大下彰彦, 菊池章
GI Res Vol. 11 No. 4 p. 279-289 2003/08/01
The role of Xenopus Idax gene in Noncanonical Wnt signaling pathway
T Michiue, K Sakurai, H Kobayashi, A Yukita, A Fukui, A Kikuchi, M Asashima
DEVELOPMENTAL BIOLOGY Vol. 259 No. 2 p. 487-488 2003/07 Research paper, summary (international conference)
Sumoylation is involved in beta-catenin-dependent activation of Tcf-4
H Yamamoto, M Ihara, Y Matsuura, A Kikuchi
EMBO JOURNAL Vol. 22 No. 9 p. 2047-2059 2003/05
Sumoylation is involved in beta-catenin-dependent activation of Tcf-4
H Yamamoto, M Ihara, Y Matsuura, A Kikuchi
EMBO JOURNAL Vol. 22 No. 9 p. 2047-2059 2003/05
ストレス応答におけるグリコーゲン合成酵素リン酸化酵素GSK-3の役割
平田 雄三, 安東 知子, 菊池 章, 石崎 康代, 吉満 政義, 栗原 毅, 藤森 正彦, 恵木 浩之, 大城 望史, 清水 洋祐, 池田 聡, 小島 康知, 川堀 勝史, 岡島 正純, 浅原 利正
日本外科学会雑誌 Vol. 104 p. 399-399 2003/04/30
Publisher: 一般社団法人日本外科学会
ヒト腎細胞におけるWnt及びPKAによるβ‐カテニンの蓄積及びその生理学的意義
丹治知恵, 山本英樹, 頼岡徳在, 河野修興, 菊池章
日本腎臓学会誌 Vol. 45 No. 3 2003/04/25
Casein kinase I epsilon enhances the binding of Dvl-1 to Frat-1 and is essential for Wnt-3a-induced accumulation of beta-catenin
S Hino, T Michiue, M Asashima, A Kikuchi
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 278 No. 16 p. 14066-14073 2003/04
Wnt Signaling Pathway in Development.
岸田昭世, 菊池章
小児外科 Vol. 35 No. 3 p. 275-283 2003/03/25
Tumor formation by genetic mutations in the components of the Wnt signaling pathway
Akira Kikuchi
Cancer Science Vol. 94 No. 3 p. 225-229 2003/03/01 Book review, literature introduction, etc.
Yeast glycogen synthase kinase-3 activates Msn2p-dependent transcription of stress responsive genes
Y Hirata, T Andoh, T Asahara, A Kikuchi
MOLECULAR BIOLOGY OF THE CELL Vol. 14 No. 1 p. 302-312 2003/01
シグナル伝達機構の異常に基づく癌化の分子機構 (特集 癌細胞のシグナル伝達)
菊池 章
モレキュラ-メディシン Vol. 39 No. 11 p. 1232-1237 2002/11
Publisher: 中山書店
癌細胞のシグナル伝達 Wntシグナル伝達の制御機構と発癌との関連
山本英樹, 池田聡, 菊池章
Mol Med Vol. 39 No. 11 p. 1264-1272 2002/11
Publisher: 中山書店
Interaction of POB1, a downstream molecule of small G protein Ral, with PAG2, a paxillin-binding protein, is involved in cell migration
T Oshiro, S Koyama, S Sugiyama, A Kondo, Y Onodera, T Asahara, H Sabe, A Kikuchi
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 277 No. 41 p. 38618-38626 2002/10
A-kinase anchoring protein AKAP220 binds to glycogen synthase kinase-3 beta (GSK-3 beta) and mediates protein kinase A-dependent inhibition of GSK-3 beta
C Tanji, H Yamamoto, N Yorioka, N Kohno, K Kikuchi, A Kikuchi
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 277 No. 40 p. 36955-36961 2002/10
Wntシグナル伝達経路の制御機構
小林雅史, 菊池章, 岡本哲治
組織培養研究 Vol. 21 No. 2/3 p. 83-92 2002/09/30
Publisher: 日本組織培養学会
SUMO化を介するWntシグナル伝達機構の制御
菊池章, 山本英樹
生化学 Vol. 74 No. 8 2002/08/25
DvlとFratによるWntシグナル伝達経路の制御
日野真一郎, 菊池章
日本癌学会総会記事 Vol. 61st 2002/08/25
Wnt経路における翻訳後修飾によるβ‐カテニンのシグナル伝達制御
菊池章
日本癌学会総会記事 Vol. 61st p. 32-33 2002/08/25
低分子量G蛋白質Ralの下流分子であるPOB1は,パキシリン結合蛋白質PAG2と結合し,細胞運動を制御する
大城 望史, 小山 眞也, 杉山 真一郎, 佐邊 壽孝, 菊池 章
生化学 Vol. 74 No. 8 p. 1049-1049 2002/08
Publisher: (公社)日本生化学会Wntシグナルとβ‐カテニン
井原基公, 山本英樹, 菊池章
月刊血液・腫よう科 Vol. 44 No. 6 p. 496-504 2002/06/28
Desumoylation activity of Axam, a novel Axin-binding protein, is involved in downregulation of beta-catenin
T Kadoya, H Yamamoto, T Suzuki, A Yukita, A Fukui, T Michiue, T Asahara, K Tanaka, M Asashima, A Kikuchi
MOLECULAR AND CELLULAR BIOLOGY Vol. 22 No. 11 p. 3803-3819 2002/06
Regulation of Wnt Signaling Pathway by Post-translational Modification.
角舎学行, 菊池章
細胞工学 Vol. 21 No. 6 p. 608-612 2002/06
Publisher: 秀潤社
Wntシグナル伝達経路と癌化とのかかわり
山本秀樹, 菊池章
Bio Clin Vol. 17 No. 5 p. 459-463 2002/05/10
Regulation of endocytosis of activin type II receptors by a novel PDZ protein through Ral/Ral-binding protein 1-dependent pathway
T Matsuzaki, S Hanai, H Kishi, ZH Liu, YL Bao, A Kikuchi, K Tsuchida, F Sugino
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 277 No. 21 p. 19008-19018 2002/05
β-カテニン結合蛋白質 Duplin の核内輸送の分子機構とその意義
小林 雅史, 菊池 章, 岡本 哲治
Tissue culture research communications : the journal of experimental & applied cell culture research = 組織培養研究 Vol. 21 No. 1 p. 41-41 2002/03/31
低分子量G蛋白質Ralの下流分子であるPOB1による細胞運動の制御
大城 望史, 小山 眞也, 菊池 章, 石崎 康代, 藤森 正彦, 恵木 浩之, 平田 雄三, 清水 洋祐, 池田 聡, 小島 康知, 川堀 勝史, 岡島 正純, 浅原 利正
日本外科学会雑誌 Vol. 103 p. 535-535 2002/03/10
Publisher: 一般社団法人日本外科学会
グリコーゲン合成酵素リン酸化酵素GSK-3とストレス応答
平田 雄三, 安東 知子, 菊池 章, 石崎 康代, 藤森 正彦, 恵木 浩之, 大城 望史, 清水 洋祐, 池田 聡, 小島 康知, 川堀 勝史, 岡島 正純, 浅原 利正
日本外科学会雑誌 Vol. 103 p. 271-271 2002/03/10
Publisher: 一般社団法人日本外科学会
Nuclear localization of Duplin, a beta-catenin-binding protein, is essential for its inhibitory activity on the Wnt signaling pathway
M Kobayashi, S Kishida, A Fukui, T Michiue, Y Miyamoto, T Okamoto, Y Yoneda, M Asashima, A Kikuchi
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 277 No. 8 p. 5816-5822 2002/02
ここまで分かった形づくりのシグナル伝達 細胞極性・細胞運動制御から情報伝達破綻による疾病まで 第3章 発生・分化・形態形成に関わるシグナリング 4 形態形成におけるWntシグナル伝達経路の役割
小林雅史, 岸田昭世, 菊池章
実験医学 Vol. 20 No. 2 p. 322-328 2002/01/25
細胞増殖におけるβ-カテニンの制御機構
日野真一郎, 菊池章
分子呼吸器病 Vol. 6 p. 22-25 2002/01
発生学から再生医療へ I 発生学の進歩 Wntシグナルによる背腹軸形成の分子機構
大下彰彦, 岸田昭世, 菊池章
医学のあゆみ Vol. 199 No. 13 p. 907-912 2001/12/29
Publisher: 医歯薬出版
DvlとカゼインキナーゼIεの相乗作用によるWntシグナルの制御
日野真一郎, 岸田想子, 山本英樹, 岸田昭世, 菊池章
日本癌学会総会記事 Vol. 60th 2001/09/26
Protein Phosphatase 2Aの調節サブユニットPR61によるWntシグナル伝達経路の抑制
山本英樹, 桧井俊英, 岸田昭世, 菊池章
日本癌学会総会記事 Vol. 60th 2001/09/26
Synergistic Activation of the Wnt Signaling Pathway by Dvl and Casein Kinase Iε
Michiko Kishida, Shin-Ichiro Hino, Tatsuo Michiue, Hideki Yamamoto, Shosei Kishida, Akimasa Fukui, Makoto Asashima, Akira Kikuchi
Journal of Biological Chemistry Vol. 276 No. 35 p. 33147-33155 2001/08/31
Ralの下流分子であるPOB1とARF-GAPとの結合による細胞運動の制御
大城 望史, 小山 眞也, 近藤 明子, 佐邊 壽孝, 菊池 章
生化学 Vol. 73 No. 8 p. 811-811 2001/08
Publisher: (公社)日本生化学会Synergistic activation of the Wnt signaling pathway by Dvl and casein kinase I epsilon
M Kishida, S Hino, T Michiue, H Yamamoto, S Kishida, A Fukui, M Asashima, A Kikuchi
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 276 No. 35 p. 33147-33155 2001/08
細胞生物学講座 Axinによるβ-カテニン制御と癌化の分子機構
池田 聡, 浅原 利正, 菊池 章
細胞 Vol. 33 No. 7 p. 268-271 2001/07
Publisher: ニュー・サイエンス社
Inhibition of the Wnt signaling pathway by the PR61 subunit of protein phosphatase 2A
H Yamamoto, T Hinoi, T Michiue, A Fukui, H Usui, Janssens, V, C Van Hoof, J Goris, M Asashima, A Kikuchi
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 276 No. 29 p. 26875-26882 2001/07
Inhibition of the Wnt signaling pathway by the PR61 subunit of protein phosphatase 2A
H Yamamoto, T Hinoi, T Michiue, A Fukui, H Usui, Janssens, V, C Van Hoof, J Goris, M Asashima, A Kikuchi
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 276 No. 29 p. 26875-26882 2001/07
Axinを介するWntシグナル伝達経路の制御機構
丹治知恵, 山本英樹, 菊池章
遺伝子医学 Vol. 5 No. 2 p. 257-264 2001/05/10
Inhibitory effect of a presenilin 1 mutation on the Wnt signalling pathway by enhancement of beta-catenin phosphorylation
Y Kawamura, A Kikuchi, R Takada, S Takada, S Sudoh, S Shibamoto, K Yanagisawa, H Komano
EUROPEAN JOURNAL OF BIOCHEMISTRY Vol. 268 No. 10 p. 3036-3041 2001/05
Wntシグナル伝達経路の異常と悪性腫よう 新規癌抑制遺伝子Axinを中心に
池田聡, 児玉真也, 清水洋祐, 藤森正彦, 恵木浩之, 岡島正純, 岸田昭世, 菊池章, 浅原利正
日本外科学会雑誌 Vol. 102 2001/03/10
Role of the ENTH domain in phosphatidylinositol-4,5-bisphosphate binding and endocytosis
T Itoh, S Koshiba, T Kigawa, A Kikuchi, S Yokoyama, T Takenawa
SCIENCE Vol. 291 No. 5506 p. 1047-1051 2001/02
Ras interaction with RalGDS effector targets
S Koyama, A Kikuchi
REGULATORS AND EFFECTORS OF SMALL GTPASES, PT F, RAS FAMILY I Vol. 332 p. 127-138 2001 Book review, literature introduction, etc.
Chondrocyte-derived ezrin-like domain containing protein (CDEP), a rho guanine nucleotide exchange factor, is inducible in chondrocytes by parathyroid hormone and cyclic AMP and has transforming activity in NIH3T3 cells.
Ostoarthritis and Cartilage 2001
Axin facilitates Smad3 activation in transforming growth factor-b signaling.
FURUHASHI M, YAGI K, YAMAMOTO H, FURUKAWA Y, SHIMADA S, NAKAMURA Y, KIKUCHI A, MIYAZONO K, KATO M
Mol. Cell. Biol. Vol. 21 No. 15 p. 5132-5141 2001
Solution structure of the epsin N-terminal homology (ENTH) domain of human epsin.
J. Struct. Funct. Genomics, p. 1-8 2001
Inhibition of the Wnt signaling pathway by Idax, a novel Dvl-binding protein
SI Hino, S Kishida, T Michiue, A Fukui, Sakamoto, I, S Takada, M Asashima, A Kikuchi
MOLECULAR AND CELLULAR BIOLOGY Vol. 21 No. 1 p. 330-342 2001/01
b-arrestin1 modulates lymphoid enhnacer factor transcriptional activity through interaction with phosphorylated dishevelled proteins.
CHEN W, HU L A, SEMENOV M V, YANAGAWA S, KIKUCHI A, LEFKOWITZ R J, MILLER W E
Proc. Natl. Acad. Sci. USA Vol. 98 No. 26 p. 14889-14894 2001
Chondrocyte-derived ezrin-like domain containing protein (CDEP), a rho guanine nucleotide exchange factor, is inducible in chondrocytes by parathyroid hormone and cyclic AMP and has transforming activity in NIH3T3 Cells
Y Koyano, T Kawamoto, A Kikuchi, M Shen, Y Kuruta, S Tsutsumi, K Fujimoto, M Noshiro, K Fujii, Y Kato
OSTEOARTHRITIS AND CARTILAGE Vol. 9 p. S64-S68 2001
Axin facilitates Smad3 activation in transforming growth factor-b signaling.
Mol. Cell. Biol. Vol. 21 No. 15 p. 5132-5141 2001
Solution structure of the epsin N-terminal homology (ENTH) domain of human epsin.
J. Struct. Funct. Genomics, p. 1-8 2001
b-arrestin1 modulates lymphoid enhnacer factor transcriptional activity through interaction with phosphorylated dishevelled proteins.
Proc. Natl. Acad. Sci. USA Vol. 98 No. 26 p. 14889-14894 2001
Inhibition of the Wnt signaling pathway by Idax, a novel Dvl-binding protein
S. I. Hino, S. Kishida, T. Michiue, A. Fukui, I. Sakamoto, S. Takada, M. Asashima, A. Kikuchi
Molecular and Cellular Biology Vol. 21 No. 1 p. 330-342 2001
Myosin II regulatory light chain as a novel substrate for AIM-1, an Aurora/Ipl1p-related kinase from rat
M Murata-Hori, K Fumoto, Y Fukuta, T Iwasaki, A Kikuchi, M Tatsuka, H Hosoya
JOURNAL OF BIOCHEMISTRY Vol. 128 No. 6 p. 903-907 2000/12
TGF‐βシグナルとWntシグナルのクロストーク‐TGF‐βシグナルに対するAxinの作用について
古橋正男, 八木健, 島田真路, 山本英樹, 菊池章, 加藤光保, 宮園浩平
日本分子生物学会年会プログラム・講演要旨集 Vol. 23rd 2000/11/25
Wntシグナル伝達経路におけるβ‐カテニンのリン酸化の制御機構
菊池章, 岸田昭世, 岸田想子, 山本英樹
日本分子生物学会年会プログラム・講演要旨集 Vol. 23rd 2000/11/25
Inhibition of Wnt signaling pathway by a novel axin-binding protein
T Kadoya, S Kishida, A Fukui, T Hinoi, T Michiue, M Asashima, A Kikuchi
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 275 No. 47 p. 37030-37037 2000/11
Inhibition of Wnt signaling pathway by a novel axin-binding protein
T Kadoya, S Kishida, A Fukui, T Hinoi, T Michiue, M Asashima, A Kikuchi
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 275 No. 47 p. 37030-37037 2000/11
Complex formation of adenomatous polyposis coli gene product and Axin facilitates glycogen synthase kinase-3 beta-dependent phosphorylation of beta-catenin and down-regulates beta-catenin
T Hinoi, H Yamamoto, M Kishida, S Takada, S Kishida, A Kikuchi
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 275 No. 44 p. 34399-34406 2000/11
Inhibition of Wnt signaling pathway by a novel axin-binding protein
T Kadoya, S Kishida, A Fukui, T Hinoi, T Michiue, M Asashima, A Kikuchi
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 275 No. 47 p. 37030-37037 2000/11
Inhibition of Wnt signaling pathway by a novel axin-binding protein
T Kadoya, S Kishida, A Fukui, T Hinoi, T Michiue, M Asashima, A Kikuchi
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 275 No. 47 p. 37030-37037 2000/11
Complex formation of adenomatous polyposis coli gene product and Axin facilitates glycogen synthase kinase-3 beta-dependent phosphorylation of beta-catenin and down-regulates beta-catenin
T Hinoi, H Yamamoto, M Kishida, S Takada, S Kishida, A Kikuchi
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 275 No. 44 p. 34399-34406 2000/11
Regulation of the Axis Formation by the Wnt Signaling Pathway.
日野真一郎, 岸田昭世, 菊池章
細胞工学 Vol. 19 No. 11 p. 1606-1615 2000/11
Wntシグナル伝達経路における分子間相互作用とその制御機構 (シグナル伝達ネットワーク) -- (第2部 シグナル伝達ネットワークにおけるクロストークと制御機構)
岸田 想子, 岸田 昭世, 菊池 章
現代化学増刊 No. 37 p. 115-122 2000/10
Publisher: 東京化学同人
Effects of rat Axin domains on axis formation in Xenopus embryos
A Fukui, S Kishida, A Kikuchi, M Asashima
DEVELOPMENT GROWTH & DIFFERENTIATION Vol. 42 No. 5 p. 489-498 2000/10
A novel beta-catenin-binding protein inhibits beta-catenin-dependent Tcf activation and axis formation
Sakamoto, I, S Kishida, A Fukui, M Kishida, H Yamamoto, S Hino, T Michiue, S Takada, M Asashima, A Kikuchi
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 275 No. 42 p. 32871-32878 2000/10
Effects of rat Axin domains on axis formation in Xenopus embryos
A Fukui, S Kishida, A Kikuchi, M Asashima
DEVELOPMENT GROWTH & DIFFERENTIATION Vol. 42 No. 5 p. 489-498 2000/10
A novel beta-catenin-binding protein inhibits beta-catenin-dependent Tcf activation and axis formation
Sakamoto, I, S Kishida, A Fukui, M Kishida, H Yamamoto, S Hino, T Michiue, S Takada, M Asashima, A Kikuchi
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 275 No. 42 p. 32871-32878 2000/10
Wntシグナル伝達系における変異プレセニリン1の抑制作用
川村勇樹, 菊池章, 高田律子, 高田慎治, 芝本さゆみ, 柳沢勝彦, 駒野宏人
神経化学 Vol. 39 No. 3 2000/10/01
Yeast glycogen synthase kinase 3 is involved in protein degradation in cooperation with Bul1, Bul2, and Rsp5
T Andoh, Y Hirata, A Kikuchi
MOLECULAR AND CELLULAR BIOLOGY Vol. 20 No. 18 p. 6712-6720 2000/09
Yeast glycogen synthase kinase 3 is involved in protein degradation in cooperation with Bul1, Bul2, and Rsp5
T Andoh, Y Hirata, A Kikuchi
MOLECULAR AND CELLULAR BIOLOGY Vol. 20 No. 18 p. 6712-6720 2000/09
Yeast glycogen synthase kinase 3 is involved in protein degradation in cooperation with Bul1, Bul2, and Rsp5
T Andoh, Y Hirata, A Kikuchi
MOLECULAR AND CELLULAR BIOLOGY Vol. 20 No. 18 p. 6712-6720 2000/09
Wntシグナル伝達経路の構成分子DvlのPDZ領域と結合する新規蛋白質の同定と機能解析
日野真一郎, 岸田昭世, 菊池章
Japanese Journal of Cancer Research Vol. 91 No. Supplement (Sept) 2000/09/01
Wnt経路におけるβ‐カテニンのシグナル伝達とがん
菊池章, 岸田昭世, 岸田想子, 山本英樹
Japanese Journal of Cancer Research Vol. 91 No. Supplement (Sept) 2000/09/01
Wntシグナル抑制因子Axinに結合する新規蛋白質の同定とその機能解析
角舎学行, 岸田昭世, 菊池章
Jpn J Cancer Res Vol. 91 No. Supplement (Sept) 2000/09/01
Wntシグナル伝達系におけるプレセニリン1の役割
川村勇樹, 菊池章, 高田律子, 高田慎治, 芝本さゆみ, 柳沢勝彦, 駒野宏人
生化学 Vol. 72 No. 8 2000/08/25
Wntシグナル伝達機構を構成する新規分子による体軸形成制御
菊池章, 岸田昭世, 岸田想子, 山本英樹
生化学 Vol. 72 No. 8 2000/08/25
Regulation of complex formation of POB1/epsin/adaptor protein complex 2 by mitotic phosphorylation
K Kariya, S Koyama, S Nakashima, T Oshiro, K Morinaka, A Kikuchi
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 275 No. 24 p. 18399-18406 2000/06
Regulation of complex formation of POB1/epsin/adaptor protein complex 2 by mitotic phosphorylation
K Kariya, S Koyama, S Nakashima, T Oshiro, K Morinaka, A Kikuchi
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 275 No. 24 p. 18399-18406 2000/06
Regulation of complex formation of POB1/epsin/adaptor protein complex 2 by mitotic phosphorylation
K Kariya, S Koyama, S Nakashima, T Oshiro, K Morinaka, A Kikuchi
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 275 No. 24 p. 18399-18406 2000/06
Regulation of complex formation of POB1/epsin/adaptor protein complex 2 by mitotic phosphorylation
K Kariya, S Koyama, S Nakashima, T Oshiro, K Morinaka, A Kikuchi
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 275 No. 24 p. 18399-18406 2000/06
NE-dlg, a mammalian homolog of Drosophila DLG tumor suppressor, induces growth suppression and impairment of cell adhesion: Possible involvement of down-regulation of beta-catenin by NE-dlg expression
N Hanada, K Makino, H Koga, T Morisaki, H Kuwahara, N Masuko, Y Tabira, T Hiraoka, N Kitamura, A Kikuchi, H Saya
INTERNATIONAL JOURNAL OF CANCER Vol. 86 No. 4 p. 480-488 2000/05
SF25c-4 細胞質beta-cateninの発癌への関与 : APC/Axinによる調節機構を中心に
池田 聡, 児玉 真也, 清水 洋祐, 大城 望史, 平田 雄三, 中島 真太郎, 羽路 一, 吉川 雅文, 中原 雅浩, 小島 康知, 川堀 勝史, 岡島 正純, 岸田 昭世, 菊池 章, 土肥 雪彦, 浅原 利正
日本外科学会雑誌 Vol. 101 p. 169-169 2000/03/10
Publisher: 一般社団法人日本外科学会
Wntシグナル伝達系におけるgamma‐catenin調節機構とその役割
児玉真也, 池田聡, 清水洋祐, 大城望史, 平田雄三, 中島真太郎, 岸田昭世, 菊池章, 土肥雪彦
日本外科学会雑誌 Vol. 101 p. 216-216 2000/03/10
Publisher: 一般社団法人日本外科学会
Regulation of β-catenin signaling in the Wnt pathway
Akira Kikuchi
Biochemical and Biophysical Research Communications Vol. 268 No. 2 p. 243-248 2000/02/16 Book review, literature introduction, etc.
Publisher: Academic Press Inc.
βカテニンの分解制御と癌 (特集 ユビキチンシステムと癌)
岸田 昭世, 菊池 章
モレキュラ-メディシン Vol. 37 No. 2 p. 166-175 2000/02
Publisher: 中山書店
Regulation of β-catenin signaling in the Wnt pathway
KIKUCHI A.
Biochem. Biophys. Res. Commun. Vol. 268 No. 2 p. 243-248 2000
NE-dlg, a mammalian homolog of Drosophila DLG tumor suppressor, induces growth suppression and impairment of cell adhesion: Possible involvement of down-regulation of b-catenin by NE-dlg expression.
HANADA N, MAKINO K, KOGA H, MORISAKI T, KUWAHARA H, HIRAOKA T, KITAMURA N, KIKUCHI A, SAYA H
Int. J. Cancer Vol. 86 No. 4 p. 480-488 2000
GSK-3 b-dependent phosphorylation of adenomatous polyposis coli gene product can be modulated by b-catenin and protein phosphatase 2A complexed with Axin.
Oncogene p. 308-318 2000
Complex Formation of Adenomatous Polyposis Coli Gene Product and Axin Facilitates GSK-3 b-dependent Phosphorylation of b-Catenin and Downregulates b-Catenin.
HINOI T, YAMAMOTO H, KISHIDA M, TAKADA S, KISHIDA S, KIKUCHI A
J. Biol. Chem. Vol. 275 No. 44 p. 34399-34406 2000
A novel b-catenin binding protein inhibits b-catenin-dependent Tcf activation and axis formation.
SAKAMOTO I, KISHIDA S, FUKUI A, KISHIDA M, YAMAMOTO H, MICHIUE T, TAKADA S, ASASHIMA M, KIKUCHI A
J. Biol. Chem. Vol. 275 No. 42 p. 32871-32878 2000
Yeast glycoge synatase kinase 3 is involved in the protein degradation in cooperation with Bul1, Bul2, and Rsp5.
Mol. Cell. Biol. Vol. 20 No. 18 p. 6712-6720 2000
GSK-3 b-dependent phosphorylation of adenomatous polyposis coli gene product can be modulated by b-catenin and protein phosphatase 2A complexed with Axin.
Oncogene p. 308-318 2000
Complex Formation of Adenomatous Polyposis Coli Gene Product and Axin Facilitates GSK-3 b-dependent Phosphorylation of b-Catenin and Downregulates b-Catenin.
J. Biol. Chem. Vol. 275 No. 44 p. 34399-34406 2000
A novel b-catenin binding protein inhibits b-catenin-dependent Tcf activation and axis formation.
J. Biol. Chem. Vol. 275 No. 42 p. 32871-32878 2000
Wntシグナル伝達抑制因子Axinによるβカテニンの分解制御機構
山本英樹, 岸田昭世, 菊池章
GI Res Vol. 7 No. 6 p. 512-517 1999/12/01
ZIP kinase identified as a novel myosin regulatory light chain kinase in HeLa cells.
M Murata-Hori, F Suizu, T Iwasaki, A Kikuchi, H Hosoya
MOLECULAR BIOLOGY OF THE CELL Vol. 10 p. 166A-166A 1999/11 Research paper, summary (international conference)
Roles of axin in the Wnt signalling pathway
A Kikuchi
CELLULAR SIGNALLING Vol. 11 No. 11 p. 777-788 1999/11 Book review, literature introduction, etc.
Roles of axin in the Wnt signalling pathway
Akira Kikuchi
Cellular Signalling Vol. 11 No. 11 p. 777-788 1999/11 Book review, literature introduction, etc.
Distinct domains of mouse dishevelled are responsible for the c-Jun N-terminal kinase/stress-activated protein kinase activation and the axis formation in vertebrates
T Moriguchi, K Kawachi, S Kamakura, N Masuyama, H Yamanaka, K Matsumoto, A Kikuchi, E Nishida
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 274 No. 43 p. 30957-30962 1999/10
Epsin binds to the EH domain of POB1 and regulates receptor-mediated endocytosis
K Morinaka, S Koyama, S Nakashima, T Hinoi, K Okawa, A Iwamatsu, A Kikuchi
ONCOGENE Vol. 18 No. 43 p. 5915-5922 1999/10
Distinct domains of mouse dishevelled are responsible for the c-Jun N-terminal kinase/stress-activated protein kinase activation and the axis formation in vertebrates
T Moriguchi, K Kawachi, S Kamakura, N Masuyama, H Yamanaka, K Matsumoto, A Kikuchi, E Nishida
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 274 No. 43 p. 30957-30962 1999/10
Axin directly interacts with plakoglobin and regulates its stability
Shinya Kodama, Satoshi Ikeda, Toshimasa Asahara, Michiko Kishida, Akira Kikuchi
Journal of Biological Chemistry Vol. 274 No. 39 p. 27682-27688 1999/09/24
Modulation of Wnt signaling by Axin and Axil
A Kikuchi
CYTOKINE & GROWTH FACTOR REVIEWS Vol. 10 No. 3-4 p. 255-265 1999/09
Cdc42 and Rac1 regulate the interaction of IQGAP1 with beta-catenin
M Fukata, S Kuroda, M Nakagawa, A Kawajiri, N Itoh, Shoji, I, Y Matsuura, S Yonehara, H Fujisawa, A Kikuchi, K Kaibuchi
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 274 No. 37 p. 26044-26050 1999/09
Axin directly interacts with plakoglobin and regulates its stability
S Kodama, S Ikeda, T Asahara, M Kishida, A Kikuchi
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 274 No. 39 p. 27682-27688 1999/09
Modulation of Wnt signaling by Axin and Axil
A. Kikuchi
Cytokine and Growth Factor Reviews Vol. 10 No. 3-4 p. 255-265 1999/09 Book review, literature introduction, etc.
Axin directly interacts with plakoglobin and regulates its stability
S Kodama, S Ikeda, T Asahara, M Kishida, A Kikuchi
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 274 No. 39 p. 27682-27688 1999/09
Axin directly interacts with plakoglobin and regulates its stability
S Kodama, S Ikeda, T Asahara, M Kishida, A Kikuchi
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 274 No. 39 p. 27682-27688 1999/09
Wntシグナル伝達系におけるAxinのリン酸化の役割
岸田昭世, 山本英樹, 岸田想子, 池田聡, 小山真也, 菊池章
日本癌学会総会記事 Vol. 58th 1999/08/30
The Drosophila Ral GTPase regulates developmental cell shape changes through the jun NH2-terminal kinase pathway
K Sawamoto, P Winge, S Koyama, Y Hirota, C Yamada, S Miyao, S Yoshikawa, MH Jin, A Kikuchi, H Okano
JOURNAL OF CELL BIOLOGY Vol. 146 No. 2 p. 361-372 1999/07
Small G protein Ral and its downstream molecules regulate endocytosis of EGF and insulin receptors
S Nakashima, K Morinaka, S Koyama, M Ikeda, M Kishida, K Okawa, A Iwamatsu, S Kishida, A Kikuchi
EMBO JOURNAL Vol. 18 No. 13 p. 3629-3642 1999/07
The Drosophila Ral GTPase regulates developmental cell shape changes through the jun NH2-terminal kinase pathway
K Sawamoto, P Winge, S Koyama, Y Hirota, C Yamada, S Miyao, S Yoshikawa, MH Jin, A Kikuchi, H Okano
JOURNAL OF CELL BIOLOGY Vol. 146 No. 2 p. 361-372 1999/07
Small G protein Ral and its downstream molecules regulate endocytosis of EGF and insulin receptors
S Nakashima, K Morinaka, S Koyama, M Ikeda, M Kishida, K Okawa, A Iwamatsu, S Kishida, A Kikuchi
EMBO JOURNAL Vol. 18 No. 13 p. 3629-3642 1999/07
The Drosophila Ral GTPase regulates developmental cell shape changes through the jun NH2-terminal kinase pathway
K Sawamoto, P Winge, S Koyama, Y Hirota, C Yamada, S Miyao, S Yoshikawa, MH Jin, A Kikuchi, H Okano
JOURNAL OF CELL BIOLOGY Vol. 146 No. 2 p. 361-372 1999/07
Small G protein Ral and its downstream molecules regulate endocytosis of EGF and insulin receptors
S Nakashima, K Morinaka, S Koyama, M Ikeda, M Kishida, K Okawa, A Iwamatsu, S Kishida, A Kikuchi
EMBO JOURNAL Vol. 18 No. 13 p. 3629-3642 1999/07
The Drosophila Ral GTPase regulates developmental cell shape changes through the jun NH2-terminal kinase pathway
K Sawamoto, P Winge, S Koyama, Y Hirota, C Yamada, S Miyao, S Yoshikawa, MH Jin, A Kikuchi, H Okano
JOURNAL OF CELL BIOLOGY Vol. 146 No. 2 p. 361-372 1999/07
Small G protein Ral and its downstream molecules regulate endocytosis of EGF and insulin receptors
S Nakashima, K Morinaka, S Koyama, M Ikeda, M Kishida, K Okawa, A Iwamatsu, S Kishida, A Kikuchi
EMBO JOURNAL Vol. 18 No. 13 p. 3629-3642 1999/07
1344 細胞質β-catenin調節因子Axinの大腸癌における性状解析
児玉 真也, 池田 聡, 中島 真太郎, 清水 洋祐, 羽路 一, 吉川 雅文, 小林 理一郎, 中原 雅浩, 川堀 勝史, 岡島 正純, 岸田 昭世, 菊池 章, 浅原 利正, 土肥 雪彦
日本消化器外科学会雑誌 Vol. 32 No. 6 p. 1908-1908 1999/06/01
Publisher: 一般社団法人日本消化器外科学会
310 Wntシグナル伝達系の負の調節因子Axinの細胞質βカテニン調節機構
池田 聡, 児玉 真也, 中島 真太郎, 清水 洋祐, 羽路 一, 吉川 雅文, 小林 理一郎, 中原 雅浩, 川堀 勝史, 岡島 正純, 岸田 昭世, 菊池 章, 浅原 利正, 土肥 雪彦
日本消化器外科学会雑誌 Vol. 32 No. 6 p. 1640-1640 1999/06/01
Publisher: 一般社団法人日本消化器外科学会
DIX domains of Dvl and Axin are necessary for protein interactions and their ability to regulate beta-catenin stability
S Kishida, H Yamamoto, S Hino, S Ikeda, M Kishida, A Kikuchi
MOLECULAR AND CELLULAR BIOLOGY Vol. 19 No. 6 p. 4414-4422 1999/06
DIX domains of Dvl and Axin are necessary for protein interactions and their ability to regulate beta-catenin stability
S Kishida, H Yamamoto, S Hino, S Ikeda, M Kishida, A Kikuchi
MOLECULAR AND CELLULAR BIOLOGY Vol. 19 No. 6 p. 4414-4422 1999/06
DIX domains of Dvl and Axin are necessary for protein interactions and their ability to regulate beta-catenin stability
S Kishida, H Yamamoto, S Hino, S Ikeda, M Kishida, A Kikuchi
MOLECULAR AND CELLULAR BIOLOGY Vol. 19 No. 6 p. 4414-4422 1999/06
An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of β-catenin
Masatoshi Kitagawa, Shigetsugu Hatakeyama, Michiko Shirane, Masaki Matsumoto, Noriko Ishida, Kimihiko Hattori, Ikuo Nakamichi, Akira Kikuchi, Kei-Ichi Nakayama, Keiko Nakayama
EMBO Journal Vol. 18 No. 9 p. 2401-2410 1999/05/04
An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of β-catenin
Masatoshi Kitagawa, Shigetsugu Hatakeyama, Michiko Shirane, Masaki Matsumoto, Noriko Ishida, Kimihiko Hattori, Ikuo Nakamichi, Akira Kikuchi, Kei-Ichi Nakayama, Keiko Nakayama
EMBO Journal Vol. 18 No. 9 p. 2401-2410 1999/05/04
ZIP kinase identified as a novel myosin regulatory light chain kinase in HeLa cells
M Murata-Hori, F Suizu, T Iwasaki, A Kikuchi, H Hosoya
FEBS LETTERS Vol. 451 No. 1 p. 81-84 1999/05
An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of beta-catenin
M Kitagawa, S Hatakeyama, M Shirane, M Matsumoto, N Ishida, K Hattori, Nakamichi, I, A Kikuchi, K Nakayama, K Nakayama
EMBO JOURNAL Vol. 18 No. 9 p. 2401-2410 1999/05
An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of beta-catenin
M Kitagawa, S Hatakeyama, M Shirane, M Matsumoto, N Ishida, K Hattori, Nakamichi, I, A Kikuchi, K Nakayama, K Nakayama
EMBO JOURNAL Vol. 18 No. 9 p. 2401-2410 1999/05
Phosphorylation of axin, a Wnt signal negative regulator, by glycogen synthase kinase-3β regulates its stability
Hideki Yamamoto, Shosei Kishida, Michiko Kishida, Satoshi Ikeda, Shinji Takada, Akira Kikuchi
Journal of Biological Chemistry Vol. 274 No. 16 p. 10681-10684 1999/04/16
Phosphorylation of Axin, a Wnt signal negative regulator, by glycogen synthase kinase-3 beta regulates its stability
H Yamamoto, S Kishida, M Kishida, S Ikeda, S Takada, A Kikuchi
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 274 No. 16 p. 10681-10684 1999/04
Phosphorylation of Axin, a Wnt signal negative regulator, by glycogen synthase kinase-3 beta regulates its stability
H Yamamoto, S Kishida, M Kishida, S Ikeda, S Takada, A Kikuchi
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 274 No. 16 p. 10681-10684 1999/04
Double-mutant analysis of the interaction of Ras with the Ras-binding domain of RGL
M Shirouzu, K Hashimoto, A Kikuchi, S Yokoyama
BIOCHEMISTRY Vol. 38 No. 16 p. 5103-5110 1999/04
Ectopic expression of constitutively activated Ral GTPase inhibits cell shape changes during Drosophila eye development
K Sawamoto, C Yamada, S Kishida, Y Hirota, A Taguchi, A Kikuchi, H Okano
ONCOGENE Vol. 18 No. 11 p. 1967-1974 1999/03
P-116 細胞質βカテニン調節因子Axinの大腸癌における性状解析
児玉 真也, 池田 聡, 中島 真太郎, 清水 洋祐, 羽路 一, 吉川 雅文, 小林 理一郎, 中原 雅浩, 川堀 勝史, 岡島 正純, 岸田 昭世, 菊池 章, 浅原 利正, 土肥 雪彦
日本外科学会雑誌 Vol. 100 p. 340-340 1999/02/10
Publisher: 一般社団法人日本外科学会
O-136 細胞質βカテニン調節因子Axinの基礎的研究 : βカテニン分解機構とAPCとの関係
池田 聡, 児玉 真也, 中島 真太郎, 清水 洋祐, 羽路 一, 吉川 雅文, 小林 理一郎, 中原 雅浩, 川堀 勝史, 岡島 正純, 岸田 昭世, 菊池 章, 浅原 利正, 土肥 雪彦
日本外科学会雑誌 Vol. 100 p. 141-141 1999/02/10
Publisher: 一般社団法人日本外科学会
Plasma membrane recruitment of RalGDS is critical for Ras-dependent Ral activation
K Matsubara, S Kishida, Y Matsuura, H Kitayama, M Noda, A Kikuchi
ONCOGENE Vol. 18 No. 6 p. 1303-1312 1999/02
DIX domains of Drl and Axin are necessary for protein interactions and their ability to reglate β-catenin stability
Mol. Cell. Biol. Vol. 19 No. 6 1999
Axin prevents Wnt-3a-induced accumulation of beta-catenin
M Kishida, S Koyama, S Kishida, K Matsubara, S Nakashima, K Higano, R Takada, S Takada, A Kikuchi
ONCOGENE Vol. 18 No. 4 p. 979-985 1999/01
Solution structure of the Eps15 homology domain of a human POB1 (partner of RalBP1)
S Koshiba, T Kigawa, J Iwahara, A Kikuchi, S Yokoyama
FEBS LETTERS Vol. 442 No. 2-3 p. 138-142 1999/01
Axin prevents Wnt-3a-induced accumulation of beta-catenin
M Kishida, S Koyama, S Kishida, K Matsubara, S Nakashima, K Higano, R Takada, S Takada, A Kikuchi
ONCOGENE Vol. 18 No. 4 p. 979-985 1999/01
Cdc42 and Rac1 Regulate the Interaction of IQGAP1 with b -catenin.
J. Biol. Chem. Vol. 274 No. 37 p. 26044-26050 1999
Phosphorylation of Axin, a Wnt signal negative regulator, by glycogen synthase kinase-3b regulates its stability.
J. Biol. Chem. Vol. 274 No. 16 p. 10681-10684 1999
Two novel proteins associated with PDZ domain of DVL-1, a human Dsh homolog
SAKAMOTO Ikuo, HINOI Takao, IKEDA Masahiro, KISHIDA Shosei, KIKUCHI Akira
Vol. 21 p. 547-547 1998/12/01
Analysis of signal transduction through glycogen synthase kinase-3 in Saccharomyces cerevisiae
ANDOH Tomoko, KIKUCHI Akira
Vol. 21 p. 547-547 1998/12/01
The Rel GTP ase regulates cell shape changes through the JNK pathway
SAWAMOTO Kazunobu, WINGE Per, KISHIDA Shosei, HIROTA Yuki, YAMADA Chiharu, MIYAO Sachiyo, JIN Ming-hao, KIKUCHI Akira, OKANO Hideyuki
Vol. 21 p. 527-527 1998/12/01
Identification of Ce-AF-6, a novel Caenorhabditis elegans protein, as a putative Ras effector
Y Watari, K Kariya, M Shibatohge, YH Liao, CD Hu, M Goshima, M Tamada, A Kikuchi, T Kataoka
GENE Vol. 224 No. 1-2 p. 53-58 1998/12
Solution structure of the Ras-binding domain of RGL
T Kigawa, M Endo, Y Ito, M Shirouzu, A Kikuchi, S Yokoyama
FEBS LETTERS Vol. 441 No. 3 p. 413-418 1998/12
Wntシグナル伝達抑制因子Axilの同定と生化学的性状の解析
山本英樹, 岸田昭世, 魚地孝聡, 池田聡, 小山真也, 浅島誠, 菊池章
日本分子生物学会年会プログラム・講演要旨集 Vol. 21st 1998/11
A role of Axin, a negative regulator of the Wnt signaling pathway, in axis formation.
菊池章
実験医学 Vol. 16 No. 17 p. 2173-2179 1998/11
Axin, a negative regulator of the Wnt signaling pathway, and degradation of .BETA.-catenin.
池田聡, 岸田昭世, 菊池章
実験医学 Vol. 16 No. 13 p. 1656-1658 1998/09
Axil, a member of the Axin family, interacts with both glycogen synthase kinase 3 beta and beta-catenin and inhibits axis formation of Xenopus embryos
H Yamamoto, S Kishida, T Uochi, S Ikeda, S Koyama, M Asashima, A Kikuchi
MOLECULAR AND CELLULAR BIOLOGY Vol. 18 No. 5 p. 2867-2875 1998/05
Communication - Axin, a negative regulator of the Wnt signaling pathway, directly interacts with adenomatous polyposis coli and regulates the stabilization of beta-catenin
S Kishida, H Yamamoto, S Ikeda, M Kishida, Sakamoto, I, S Koyama, A Kikuchi
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 273 No. 18 p. 10823-10826 1998/05
Axil, a member of the Axin family, interacts with both glycogen synthase kinase 3 beta and beta-catenin and inhibits axis formation of Xenopus embryos
H Yamamoto, S Kishida, T Uochi, S Ikeda, S Koyama, M Asashima, A Kikuchi
MOLECULAR AND CELLULAR BIOLOGY Vol. 18 No. 5 p. 2867-2875 1998/05
Axil, a member of the Axin family, interacts with both glycogen synthase kinase 3 beta and beta-catenin and inhibits axis formation of Xenopus embryos
H Yamamoto, S Kishida, T Uochi, S Ikeda, S Koyama, M Asashima, A Kikuchi
MOLECULAR AND CELLULAR BIOLOGY Vol. 18 No. 5 p. 2867-2875 1998/05
Communication - Axin, a negative regulator of the Wnt signaling pathway, directly interacts with adenomatous polyposis coli and regulates the stabilization of beta-catenin
S Kishida, H Yamamoto, S Ikeda, M Kishida, Sakamoto, I, S Koyama, A Kikuchi
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 273 No. 18 p. 10823-10826 1998/05
Axil, a member of the Axin family, interacts with both glycogen synthase kinase 3 beta and beta-catenin and inhibits axis formation of Xenopus embryos
H Yamamoto, S Kishida, T Uochi, S Ikeda, S Koyama, M Asashima, A Kikuchi
MOLECULAR AND CELLULAR BIOLOGY Vol. 18 No. 5 p. 2867-2875 1998/05
Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3β and β-catenin and promotes GSK-3β-dependent phosphorylation of β-catenin
Satoshi Ikeda, Shosei Kishida, Hideki Yamamoto, Hiroshi Murai, Shinya Koyama, Akira Kikuchi
EMBO Journal Vol. 17 No. 5 p. 1371-1384 1998/03/02
Interactions of the amino acid residue at position 31 of the c-Ha-Ras protein with Raf-1 and RalGDS
M Shirouzu, K Morinaka, S Koyama, CD Hu, N Hori-Tamura, T Okada, K Kariya, T Kataoka, A Kikuchi, S Yokoyama
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 273 No. 13 p. 7737-7742 1998/03
Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3 beta and beta-catenin and promotes GSK-3 beta-dependent phosphorylation of beta-catenin
S Ikeda, S Kishida, H Yamamoto, H Murai, S Koyama, A Kikuchi
EMBO JOURNAL Vol. 17 No. 5 p. 1371-1384 1998/03
Interactions of the amino acid residue at position 31 of the c-Ha-Ras protein with Raf-1 and RalGDS
M Shirouzu, K Morinaka, S Koyama, CD Hu, N Hori-Tamura, T Okada, K Kariya, T Kataoka, A Kikuchi, S Yokoyama
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 273 No. 13 p. 7737-7742 1998/03
Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3 beta and beta-catenin and promotes GSK-3 beta-dependent phosphorylation of beta-catenin
S Ikeda, S Kishida, H Yamamoto, H Murai, S Koyama, A Kikuchi
EMBO JOURNAL Vol. 17 No. 5 p. 1371-1384 1998/03
Identification and characterization of a novel protein interacting with Ral-binding protein 1, a putative effector protein of Ral
Masahiro Ikeda, Osamu Ishida, Takao Hinoi, Shosei Kishida, Akira Kikuchi
Journal of Biological Chemistry Vol. 273 No. 2 p. 814-821 1998/01/09
Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3b and b-catenin and promotes GSK-3b-dependent phosphorylation of b-catenin.
IKEDA S, KISHIDA S, YAMAMOTO H, MURAI H, KOYAMA S, KIKUCHI A
EMBO J. Vol. 17 No. 5 p. 1371-1384 1998
Identification and characterization of a novel protein interacting with Ral-binding protein 1, a putative effector protein of Ral
M Ikeda, O Ishida, T Hinoi, S Kishida, A Kikuchi
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 273 No. 2 p. 814-821 1998/01
Identification and characterization of a novel protein interacting with Ral-binding protein 1, a putative effector protein of Ral
M Ikeda, O Ishida, T Hinoi, S Kishida, A Kikuchi
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 273 No. 2 p. 814-821 1998/01
Axin, a negative regulator of the Wnt signaling pathway, directly interacts with adenomatous polyposis coli and regulates the stabilization of b-catenin.
KISHIDA S, YAMAMOTO H, IKEDA S, KISHIDA M, SAKAMOTO I, KOYAMA S, KIKUCHI A
J. Biol. Chem. Vol. 273 No. 18 p. 10823-10826 1998
Identification and characterization of a novel protein interacting with Ral-binding protein 1, a putative effector protein of Ral
M Ikeda, O Ishida, T Hinoi, S Kishida, A Kikuchi
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 273 No. 2 p. 814-821 1998/01
Axin, a negative regulator of the Wnt signaling pathway, directly interacts with adenomatous polyposis coli and regulates the stabilization of b-catenin.
J. Biol. Chem. Vol. 273 No. 18 p. 10823-10826 1998
Colocalization of Ras and Ral on the membrane is required for Ras-dependent Ral activation through Ral GDP dissociation stimulator
S Kishida, S Koyama, K Matsubara, M Kishida, Y Matsuura, A Kikuchi
ONCOGENE Vol. 15 No. 24 p. 2899-2907 1997/12
Regulation of cross-linking of actin filament by IQGAP1, a target for Cdc42
M Fukata, S Kuroda, K Fujii, T Nakamura, Shoji, I, Y Matsuura, K Okawa, A Iwamatsu, A Kikuchi, K Kaibuchi
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 272 No. 47 p. 29579-29583 1997/11
Regulation of cross-linking of actin filament by IQGAP1, a target for Cdc42
M Fukata, S Kuroda, K Fujii, T Nakamura, Shoji, I, Y Matsuura, K Okawa, A Iwamatsu, A Kikuchi, K Kaibuchi
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 272 No. 47 p. 29579-29583 1997/11
The post-translational modifications of Ral and Rac1 are important for the action of Ral-binding protein 1, a putative effector protein of Ral
K Matsubara, T Hinoi, S Koyama, A Kikuchi
FEBS LETTERS Vol. 410 No. 2-3 p. 169-174 1997/06
Characterization of Ral GDP dissociation stimulator-like (RGL) activities to regulate c-fos promoter and the GDP/GTP exchange of Ral
H Murai, M Ikeda, S Kishida, O Ishida, M OkazakiKishida, Y Matsuura, A Kikuchi
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 272 No. 16 p. 10483-10490 1997/04
Characterization of Ral GDP dissociation stimulator-like (RGL) activities to regulate c-fos promoter and the GDP/GTP exchange of Ral
H Murai, M Ikeda, S Kishida, O Ishida, M OkazakiKishida, Y Matsuura, A Kikuchi
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 272 No. 16 p. 10483-10490 1997/04
Synergistic activation of c-fos promoter activity by Raf and Ral GDP dissociation stimulator
M Okazaki, S Kishida, T Hinoi, T Hasegawa, M Tamada, T Kataoka, A Kikuchi
ONCOGENE Vol. 14 No. 5 p. 515-521 1997/02
RalGDS mediates an intracellular signal-transduction system from a proto-oncogene product Ras
S Koyama, S Kishida, A Kikuchi
SEIKAGAKU Vol. 68 No. 10 p. 1646-1650 1996/10 Book review, literature introduction, etc.
RasからRa1へのシグナル伝達機構の解析
池田 昌博, 小山 眞也, 村井 博, 檜井 孝夫, 岸田 昭世, 菊池 章
日本分子生物学会年会プログラム・講演要旨集 Vol. 19 p. 315-315 1996/08/01
細胞外刺激によるチロシン脱リン酸を介するグリコーゲン合成酵素キナーゼ-3(GSK-3)の活性制御
村井 博, 岡崎 想子, 小山 眞也, 菊池 章
日本分子生物学会年会プログラム・講演要旨集 Vol. 19 p. 616-616 1996/08/01
Post-translational modifications of Ras and Ral are important for the action of Ral GDP dissociation stimulator
T Hinoi, S Kishida, S Koyama, M Ikeda, Y Matsuura, A Kikuchi
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 271 No. 33 p. 19710-19716 1996/08
Post-translational modifications of Ras and Ral are important for the action of Ral GDP dissociation stimulator
T Hinoi, S Kishida, S Koyama, M Ikeda, Y Matsuura, A Kikuchi
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 271 No. 33 p. 19710-19716 1996/08
Tyrosine dephosphorylation of glycogen synthase kinase-3 is involved in its extracellular signal-dependent inactivation
H Murai, M Okazaki, A Kikuchi
FEBS LETTERS Vol. 392 No. 2 p. 153-160 1996/08
Post-translational modifications of Ras and Ral are important for the action of Ral GDP dissociation stimulator
T Hinoi, S Kishida, S Koyama, M Ikeda, Y Matsuura, A Kikuchi
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 271 No. 33 p. 19710-19716 1996/08
Post-translational modifications of Ras and Ral are important for the action of Ral GDP dissociation stimulator
T Hinoi, S Kishida, S Koyama, M Ikeda, Y Matsuura, A Kikuchi
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 271 No. 33 p. 19710-19716 1996/08
Ras-interacting domain of Ral GDP dissociation stimulator like (RGL) reverses v-Ras-induced transformation and Raf-1 activation in NIH3T3 cells
M Okazaki, S Kishida, H Murai, T Hinoi, A Kikuchi
CANCER RESEARCH Vol. 56 No. 10 p. 2387-2392 1996/05
Ras-interacting domain of Ral GDP dissociation stimulator like (RGL) reverses v-Ras-induced transformation and Raf-1 activation in NIH3T3 cells
M Okazaki, S Kishida, H Murai, T Hinoi, A Kikuchi
CANCER RESEARCH Vol. 56 No. 10 p. 2387-2392 1996/05
Ras-interacting domain of Ral GDP dissociation stimulator like (RGL) reverses v-Ras-induced transformation and Raf-1 activation in NIH3T3 cells
M Okazaki, S Kishida, H Murai, T Hinoi, A Kikuchi
CANCER RESEARCH Vol. 56 No. 10 p. 2387-2392 1996/05
Differential structural requirements for interaction of Ras protein with its distinct downstream effectors
K Akasaka, M Tamada, F Wang, K Kariya, F Shima, A Kikuchi, M Yamamoto, M Shirouzu, S Yokoyama, T Kataoka
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 271 No. 10 p. 5353-5360 1996/03
Differential structural requirements for interaction of Ras protein with its distinct downstream effectors
K Akasaka, M Tamada, F Wang, K Kariya, F Shima, A Kikuchi, M Yamamoto, M Shirouzu, S Yokoyama, T Kataoka
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 271 No. 10 p. 5353-5360 1996/03
Ras-interacting domain of RGL blocks Ras-dependent signal transduction in Xenopus oocytes
S Koyama, YW Chen, M Ikeda, AJ Muslin, LT Williams, A Kikuchi
FEBS LETTERS Vol. 380 No. 1-2 p. 113-117 1996/02
Ras-interacting domain of RGL blocks Ras-dependent signal transduction in Xenopus oocytes
S Koyama, YW Chen, M Ikeda, AJ Muslin, LT Williams, A Kikuchi
FEBS LETTERS Vol. 380 No. 1-2 p. 113-117 1996/02
Regulation of interaction of ras p21 with RalGDS and Raf-1 by cyclic AMP-dependent protein kinase
Akira Kikuchi, Lewis T. Williams
Journal of Biological Chemistry Vol. 271 No. 1 p. 588-594 1996/01/05
Publisher: American Society for Biochemistry and Molecular Biology Inc.
Regulation of interaction of ras p21 with RalGDS and raf-1 by cyclic AMP-dependent protein kinase
A Kikuchi, LT Williams
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 271 No. 1 p. 588-594 1996/01
Baculovirus-based expression of mammalian caveolin in Sf21 insect cells.
LI S, SONG K S, KOH S S, KIKUCHI A, LISANTI M P
J. Biol. Chem. Vol. 271 No. 45 p. 28647-28654 1996
Regulation of interaction of ras p21 with RalGDS and raf-1 by cyclic AMP-dependent protein kinase
A Kikuchi, LT Williams
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 271 No. 1 p. 588-594 1996/01
Regulation of interaction of ras p21 with RalGDS and Raf-1 by Cyclic AMP-dependent protein kinase.
J. Biol. Chem. Vol. 271 No. 1 p. 588-594 1996
Baculovirus-based expression of mammalian caveolin in Sf21 insect cells.
J. Biol. Chem. Vol. 271 No. 45 p. 28647-28654 1996
Ras-interacting domain of Ral GDP dissociation like(RGL)reverses V-Ras-induced transformation and Raf-1 activation in NIH3T3 cells
Cancer Res. Vol. 56 1996
REGULATION OF RAF-1-DEPENDENT SIGNALING DURING EARLY XENOPUS DEVELOPMENT
AM MACNICOL, AJ MUSLIN, EL HOWARD, A KIKUCHI, MC MACNICOL, LT WILLIAMS
MOLECULAR AND CELLULAR BIOLOGY Vol. 15 No. 12 p. 6686-6693 1995/12
REGULATION OF RAF-1-DEPENDENT SIGNALING DURING EARLY XENOPUS DEVELOPMENT
AM MACNICOL, AJ MUSLIN, EL HOWARD, A KIKUCHI, MC MACNICOL, LT WILLIAMS
MOLECULAR AND CELLULAR BIOLOGY Vol. 15 No. 12 p. 6686-6693 1995/12
REGULATION OF RAF-1-DEPENDENT SIGNALING DURING EARLY XENOPUS DEVELOPMENT
AM MACNICOL, AJ MUSLIN, EL HOWARD, A KIKUCHI, MC MACNICOL, LT WILLIAMS
MOLECULAR AND CELLULAR BIOLOGY Vol. 15 No. 12 p. 6686-6693 1995/12
RAP1 P21 REGULATES THE INTERACTION OF RAS P21 WITH RGL, A NEW EFFECTOR PROTEIN OF RAS P21
M IKEDA, S KOYAMA, M OKAZAKI, K DOHI, A KIKUCHI
FEBS LETTERS Vol. 375 No. 1-2 p. 37-40 1995/11
CHARACTERIZATION OF THE INTERACTION OF RAF-1 WITH RAS P21 OR 14-3-3-PROTEIN IN INTACT-CELLS
S KOYAMA, LT WILLIAMS, A KIKUCHI
FEBS LETTERS Vol. 368 No. 2 p. 321-325 1995/07
EFFECTS OF PRENYL MODIFICATIONS ON INTERACTIONS OF SMALL G-PROTEINS WITH REGULATORS
Y TAKAI, K KAIBUCHI, A KIKUCHI, T SASAKI
LIPID MODIFICATIONS OF PROTEINS Vol. 250 p. 122-133 1995 Book review, literature introduction, etc.
Guidebook to the small GTPases
Oxford University Press 1995
Methods in Enzymology
Academic Press 1995
Guidebook to the small GTPases
Oxford University Press 1995
Methods in Enzymology
Academic Press 1995
Regulation of Raf-1-dependent signaling during early Xenopus development
Mol. Cell. Biol. Vol. 15 No. 12 1995
RALGDS FAMILY MEMBERS INTERACT WITH THE EFFECTOR LOOP OF RAS P21
A KIKUCHI, SD DEMO, ZH YE, YW CHEN, LT WILLIAMS
MOLECULAR AND CELLULAR BIOLOGY Vol. 14 No. 11 p. 7483-7491 1994/11
RALGDS FAMILY MEMBERS INTERACT WITH THE EFFECTOR LOOP OF RAS P21
A KIKUCHI, SD DEMO, ZH YE, YW CHEN, LT WILLIAMS
MOLECULAR AND CELLULAR BIOLOGY Vol. 14 No. 11 p. 7483-7491 1994/11
ACTIVATION OF RAF-1 BY 14-3-3-PROTEINS
WJ FANTL, AJ MUSLIN, A KIKUCHI, JA MARTIN, AM MACNICOL, RW GROSS, LT WILLIAMS
NATURE Vol. 371 No. 6498 p. 612-614 1994/10
ACTIVATION OF RAF-1 BY 14-3-3-PROTEINS
WJ FANTL, AJ MUSLIN, A KIKUCHI, JA MARTIN, AM MACNICOL, RW GROSS, LT WILLIAMS
NATURE Vol. 371 No. 6498 p. 612-614 1994/10
THE POSTTRANSLATIONAL MODIFICATION OF RAS P21 IS IMPORTANT FOR RAF-1 ACTIVATION
A KIKUCHI, LT WILLIAMS
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 269 No. 31 p. 20054-20059 1994/08
THE POSTTRANSLATIONAL MODIFICATION OF RAS P21 IS IMPORTANT FOR RAF-1 ACTIVATION
A KIKUCHI, LT WILLIAMS
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 269 No. 31 p. 20054-20059 1994/08
Molecular Neurobiolog_Mechanisms
John Willy & Sons 1994
ral GDS family members interest with the effector loop of ras p21
Mol. Cell. Biol. Vol. 14 No. 11 1994
Molecular Neurobiolog_Mechanisms
John Willy & Sons 1994
The post-translational modification of ras p21 is important for Raf-1 activation
J. Biol. Chem. Vol. 269 No. 31 1994
The post-translational modification of ras p21 is important for Raf-1 activation.
J. Biol. Chem. p. 20054-20059 1994
ral GDS family members interest with the effector loop of ras p21
Mol. Cell. Biol. 1994
REQUIREMENT OF PRENYLATION OF SMALL GTP-BINDING PROTEINS FOR THEIR ACTIVATION AND FUNCTIONS
Y TAKAI, K KAIBUCHI, A KIKUCHI, T SASAKI, H SHIRATAKI, K TANAKA
FASEB JOURNAL Vol. 7 No. 7 p. A1039-A1039 1993/04 Research paper, summary (international conference)
The ras superfamily of GTPases
CRC press 1993
Ciba Foundation Symposium on the GTPase superfamily
John Wiley & Sons 1993
Handbook of Experimental Pharmacology
Springer-Verlag GmbH 1993
INVOLVEMENT OF RHO P21 AND ITS INHIBITORY GDP GTP EXCHANGE PROTEIN (RHO GDI) IN CELL MOTILITY
K TAKAISHI, A KIKUCHI, S KURODA, K KOTANI, T SASAKI, Y TAKAI
MOLECULAR AND CELLULAR BIOLOGY Vol. 13 No. 1 p. 72-79 1993/01
The ras superfamily of GTPases
CRC press 1993
Ciba Foundation Symposium on the GTPase superfamily
John Wiley & Sons 1993
Handbook of Experimental Pharmacology
Springer-Verlag GmbH 1993
REGULATION OF MORPHOLOGY BY RHO P21 AND ITS INHIBITORY GDP/GTP EXCHANGE PROTEIN (RHO GDI) IN SWISS 3T3 CELLS
Y MIURA, A KIKUCHI, T MUSHA, S KURODA, H YAKU, T SASAKI, Y TAKAI
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 268 No. 1 p. 510-515 1993/01
INVOLVEMENT OF RHO P21 AND ITS INHIBITORY GDP GTP EXCHANGE PROTEIN (RHO GDI) IN CELL MOTILITY
K TAKAISHI, A KIKUCHI, S KURODA, K KOTANI, T SASAKI, Y TAKAI
MOLECULAR AND CELLULAR BIOLOGY Vol. 13 No. 1 p. 72-79 1993/01
低分子量GTP結合タンパク質--その活性制御機構と機能
菊池 章
生化学 Vol. 64 No. 9 p. p1079-1102 1992/09
Publisher: 日本生化学会
THE SMALL GTP-BINDING PROTEINS IN THE CYTOSOL OF INSULIN-SECRETING CELLS ARE COMPLEXED TO GDP DISSOCIATION INHIBITOR PROTEINS
R REGAZZI, A KIKUCHI, Y TAKAI, CB WOLLHEIM
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 267 No. 25 p. 17512-17519 1992/09
CHARACTERIZATION OF SMALL-MOLECULAR-MASS GUANINE-NUCLEOTIDE-BINDING REGULATORY PROTEINS IN INSULIN-SECRETING CELLS AND PC12 CELLS
R REGAZZI, L VALLAR, S ULLRICH, M RAVAZZOLA, A KIKUCHI, Y TAKAI, CB WOLLHEIM
EUROPEAN JOURNAL OF BIOCHEMISTRY Vol. 208 No. 3 p. 729-737 1992/09
THE SMALL GTP-BINDING PROTEINS IN THE CYTOSOL OF INSULIN-SECRETING CELLS ARE COMPLEXED TO GDP DISSOCIATION INHIBITOR PROTEINS
R REGAZZI, A KIKUCHI, Y TAKAI, CB WOLLHEIM
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 267 No. 25 p. 17512-17519 1992/09
THE FUNCTIONAL DOMAIN OF THE STIMULATORY GDP GTP EXCHANGE PROTEIN (SMG GDS) WHICH INTERACTS WITH THE C-TERMINAL GERANYLGERANYLATED REGION OF RAP-1/KREV-1/SMG-P21
K KOTANI, A KIKUCHI, K DOI, S KISHIDA, T SAKODA, K KISHI, Y TAKAI
ONCOGENE Vol. 7 No. 9 p. 1699-1704 1992/09
CHARACTERIZATION OF SMALL-MOLECULAR-MASS GUANINE-NUCLEOTIDE-BINDING REGULATORY PROTEINS IN INSULIN-SECRETING CELLS AND PC12 CELLS
R REGAZZI, L VALLAR, S ULLRICH, M RAVAZZOLA, A KIKUCHI, Y TAKAI, CB WOLLHEIM
EUROPEAN JOURNAL OF BIOCHEMISTRY Vol. 208 No. 3 p. 729-737 1992/09
MICROINJECTION OF SMG RAP1/KREV-1 P21 INTO SWISS 3T3-CELLS INDUCES DNA-SYNTHESIS AND MORPHOLOGICAL-CHANGES
Y YOSHIDA, M KAWATA, Y MIURA, T MUSHA, T SASAKI, A KIKUCHI, Y TAKAI
MOLECULAR AND CELLULAR BIOLOGY Vol. 12 No. 8 p. 3407-3414 1992/08
MICROINJECTION OF SMG RAP1/KREV-1 P21 INTO SWISS 3T3-CELLS INDUCES DNA-SYNTHESIS AND MORPHOLOGICAL-CHANGES
Y YOSHIDA, M KAWATA, Y MIURA, T MUSHA, T SASAKI, A KIKUCHI, Y TAKAI
MOLECULAR AND CELLULAR BIOLOGY Vol. 12 No. 8 p. 3407-3414 1992/08
FUNCTIONAL INTERACTIONS OF STIMULATORY AND INHIBITORY GDP GTP EXCHANGE PROTEINS AND THEIR COMMON SUBSTRATE SMALL GTP-BINDING PROTEIN
A KIKUCHI, S KURODA, T SASAKI, K KOTANI, K HIRATA, M KATAYAMA, Y TAKAI
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 267 No. 21 p. 14611-14615 1992/07
FUNCTIONAL INTERACTIONS OF STIMULATORY AND INHIBITORY GDP GTP EXCHANGE PROTEINS AND THEIR COMMON SUBSTRATE SMALL GTP-BINDING PROTEIN
A KIKUCHI, S KURODA, T SASAKI, K KOTANI, K HIRATA, M KATAYAMA, Y TAKAI
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 267 No. 21 p. 14611-14615 1992/07
INVOLVEMENT OF RHO P21 IN THE GTP-ENHANCED CALCIUM-ION SENSITIVITY OF SMOOTH-MUSCLE CONTRACTION
K HIRATA, A KIKUCHI, T SASAKI, S KURODA, K KAIBUCHI, Y MATSUURA, H SEKI, K SAIDA, Y TAKAI
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 267 No. 13 p. 8719-8722 1992/05 Article, review, commentary, editorial, etc. (scientific journal)
COOPERATIVE FUNCTION OF RHO GDS AND RHO GDI TO REGULATE RHO P21 ACTIVATION IN SMOOTH-MUSCLE
S KURODA, A KIKUCHI, K HIRATA, T MASUDA, K KISHI, T SASAKI, Y TAKAI
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Vol. 185 No. 1 p. 473-480 1992/05
INVOLVEMENT OF RHO P21 IN THE GTP-ENHANCED CALCIUM-ION SENSITIVITY OF SMOOTH-MUSCLE CONTRACTION
K HIRATA, A KIKUCHI, T SASAKI, S KURODA, K KAIBUCHI, Y MATSUURA, H SEKI, K SAIDA, Y TAKAI
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 267 No. 13 p. 8719-8722 1992/05 Article, review, commentary, editorial, etc. (scientific journal)
COOPERATIVE FUNCTION OF RHO GDS AND RHO GDI TO REGULATE RHO P21 ACTIVATION IN SMOOTH-MUSCLE
S KURODA, A KIKUCHI, K HIRATA, T MASUDA, K KISHI, T SASAKI, Y TAKAI
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Vol. 185 No. 1 p. 473-480 1992/05
IMMUNOHISTOLOGICAL LOCALIZATION OF SMG P25A, A RAS P21-LIKE GUANOSINE 5'-TRIPHOSPHATE (GTP)-BINDING PROTEIN IN HUMAN SKIN
S INOHARA, Y TANAKA, Y KITANO, S SAGAMI, A MIZOGUCHI, A KIKUCHI, Y TAKAI
ARCHIVES OF DERMATOLOGICAL RESEARCH Vol. 284 No. 2 p. 109-110 1992/04 Article, review, commentary, editorial, etc. (scientific journal)
IMMUNOHISTOLOGICAL LOCALIZATION OF SMG P25A, A RAS P21-LIKE GUANOSINE 5'-TRIPHOSPHATE (GTP)-BINDING PROTEIN IN HUMAN SKIN
S INOHARA, Y TANAKA, Y KITANO, S SAGAMI, A MIZOGUCHI, A KIKUCHI, Y TAKAI
ARCHIVES OF DERMATOLOGICAL RESEARCH Vol. 284 No. 2 p. 109-110 1992/04 Article, review, commentary, editorial, etc. (scientific journal)
EPIDERMAL-CELL DIFFERENTIATION INHIBITOR ADP-RIBOSYLATES SMALL GTP-BINDING PROTEINS AND INDUCES HYPERPLASIA OF EPIDERMIS
M SUGAI, K HASHIMOTO, A KIKUCHI, S INOUE, H OKUMURA, K MATSUMOTO, Y GOTO, H OHGAI, K MORIISHI, B SYUTO, K YOSHIKAWA, H SUGINAKA, Y TAKAI
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 267 No. 4 p. 2600-2604 1992/02
EFFECT OF CHLORPROMAZINE ON THE SMG GDS ACTION
YS KIM, A KIKUCHI, Y TAKAI
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Vol. 182 No. 3 p. 1446-1453 1992/02
EPIDERMAL-CELL DIFFERENTIATION INHIBITOR ADP-RIBOSYLATES SMALL GTP-BINDING PROTEINS AND INDUCES HYPERPLASIA OF EPIDERMIS
M SUGAI, K HASHIMOTO, A KIKUCHI, S INOUE, H OKUMURA, K MATSUMOTO, Y GOTO, H OHGAI, K MORIISHI, B SYUTO, K YOSHIKAWA, H SUGINAKA, Y TAKAI
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 267 No. 4 p. 2600-2604 1992/02
MOLECULAR-CLONING OF THE HUMAN CDNA FOR A STIMULATORY GDP/GTP EXCHANGE PROTEIN FOR C-KI-RAS P21 AND SMG P21
A KIKUCHI, K KAIBUCHI, Y HORI, H NONAKA, T SAKODA, M KAWAMURA, T MIZUNO, Y TAKAI
ONCOGENE Vol. 7 No. 2 p. 289-293 1992/02
EFFECT OF CHLORPROMAZINE ON THE SMG GDS ACTION
YS KIM, A KIKUCHI, Y TAKAI
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Vol. 182 No. 3 p. 1446-1453 1992/02
Molecular Biology of the Myocardium
CRC press 1992
Distribution of smg p25A and smg p21s, ras p21-like guanine nucleotide binding proteins, in the rat stomach.
Am. J. Physiol. 1992
Molecular Biology of the Myocardium
CRC press 1992
SMALL GTP-BINDING PROTEINS
Y TAKAI, K KAIBUCHI, A KIKUCHI, M KAWATA
INTERNATIONAL REVIEW OF CYTOLOGY-A SURVEY OF CELL BIOLOGY Vol. 133 p. 187-230 1992 Book review, literature introduction, etc.
Distribution of smg p25A and smg p21s, ras p21-like guanine nucleotide binding proteins, in the rat stomach.
Am. J. Physiol. 1992
低分子量GTP結合蛋白質smg p25Aの調節蛋白質GDI(GDP dissociation inhibitor:smg p25A GDI)の機能および発現について
本池俊行, 佐野公彦, 中村肇, 菊池章, 貝淵弘三, 高井義美
神経化学 Vol. 30 No. 1 p. 268-269 1991/09
γas P21類似低分子量G蛋白質,smg p25Aのヒト皮膚における局在
猪原慎一, 田中靖, 喜多野征夫, 相模成一郎, 溝口明, 菊池章, 高井義美
皮膚科紀要 Vol. 86 No. 3 p. 259-262 1991/08
バイオシグナル実験法シリーズ 情報伝達系基礎実験法 GTP結合蛋白質関連蛋白解析法 低分子量GTP結合蛋白質の解析法
広吉基己, 菊池章, 高井義美
実験医学 Vol. 9 No. 9 p. 1069-1076 1991/07
SIMILARITY OF EXPRESSION OF LOW-MOLECULAR-WEIGHT G-PROTEINS SMG-P21A AND RAS-P21 IN NORMAL AND MALIGNANT HUMAN TISSUES
K TAKAYAMA, K FURUKAWA, K ABE, Y KAWASE, A MIZOGUCHI, A KIKUCHI, Y TAKAI, Y MATSUI, Y TERANISHI, E NAKAYAMA, H SHIKU
CANCER RESEARCH Vol. 51 No. 8 p. 2223-2228 1991/04
POSTTRANSLATIONAL MODIFICATIONS OF THE C-TERMINAL REGION OF THE RHO-PROTEIN ARE IMPORTANT FOR ITS INTERACTION WITH MEMBRANES AND THE STIMULATORY AND INHIBITORY GDP/GTP EXCHANGE PROTEINS
Y HORI, A KIKUCHI, M ISOMURA, M KATAYAMA, Y MIURA, H FUJIOKA, K KAIBUCHI, Y TAKAI
ONCOGENE Vol. 6 No. 4 p. 515-522 1991/04
The Status of Differentiation Therapy of Cancer
Raven Press 1991
The Status of Differentiation Therapy of Cancer
Raven Press 1991
REGULATION OF BINDING OF RHOB P20 TO MEMBRANES BY ITS SPECIFIC REGULATORY PROTEIN, GDP DISSOCIATION INHIBITOR
M ISOMURA, A KIKUCHI, N OHGA, Y TAKAI
ONCOGENE Vol. 6 No. 1 p. 119-124 1991/01
神経組織におけるras p21類似GTP結合蛋白質smg p25Aの発現について
本池俊行, 佐野公彦, 中村肇, 畠中寛, 菊池章, 高井義美
神経化学 Vol. 29 No. 1 p. 172-173 1990/09
MOLECULAR-CLONING AND CHARACTERIZATION OF A NOVEL TYPE OF REGULATORY PROTEIN (GDI) FOR THE RHO PROTEINS, RAS P21-LIKE SMALL GTP-BINDING PROTEINS
Y FUKUMOTO, K KAIBUCHI, Y HORI, H FUJIOKA, S ARAKI, T UEDA, A KIKUCHI, Y TAKAI
ONCOGENE Vol. 5 No. 9 p. 1321-1328 1990/09
PURIFICATION, CHARACTERIZATION, AND POSSIBLE FUNCTIONS OF SMALL MOLECULAR-WEIGHT GTP-BINDING PROTEINS
Y TAKAI, A KIKUCHI, M KAWATA, K YAMAMOTO, M HOSHIJIMA
AMERICAN JOURNAL OF HYPERTENSION Vol. 3 No. 8 p. S220-S223 1990/08
MOLECULAR-CLONING AND CHARACTERIZATION OF A NOVEL TYPE OF REGULATORY PROTEIN (GDI) FOR SMG P25A, A RAS P21-LIKE GTP-BINDING PROTEIN
Y MATSUI, A KIKUCHI, S ARAKI, Y HATA, J KONDO, Y TERANISHI, Y TAKAI
MOLECULAR AND CELLULAR BIOLOGY Vol. 10 No. 8 p. 4116-4122 1990/08
REGULATION OF REVERSIBLE BINDING OF SMG P25A, A RAS P21-LIKE GTP-BINDING PROTEIN, TO SYNAPTIC PLASMA-MEMBRANES AND VESICLES BY ITS SPECIFIC REGULATORY PROTEIN, GDP DISSOCIATION INHIBITOR
S ARAKI, A KIKUCHI, Y HATA, M ISOMURA, Y TAKAI
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 265 No. 22 p. 13007-13015 1990/08
PURIFICATION, CHARACTERIZATION, AND POSSIBLE FUNCTIONS OF SMALL MOLECULAR-WEIGHT GTP-BINDING PROTEINS
Y TAKAI, A KIKUCHI, M KAWATA, K YAMAMOTO, M HOSHIJIMA
AMERICAN JOURNAL OF HYPERTENSION Vol. 3 No. 8 p. S220-S223 1990/08
MOLECULAR-CLONING AND CHARACTERIZATION OF A NOVEL TYPE OF REGULATORY PROTEIN (GDI) FOR SMG P25A, A RAS P21-LIKE GTP-BINDING PROTEIN
Y MATSUI, A KIKUCHI, S ARAKI, Y HATA, J KONDO, Y TERANISHI, Y TAKAI
MOLECULAR AND CELLULAR BIOLOGY Vol. 10 No. 8 p. 4116-4122 1990/08
REGULATION OF REVERSIBLE BINDING OF SMG P25A, A RAS P21-LIKE GTP-BINDING PROTEIN, TO SYNAPTIC PLASMA-MEMBRANES AND VESICLES BY ITS SPECIFIC REGULATORY PROTEIN, GDP DISSOCIATION INHIBITOR
S ARAKI, A KIKUCHI, Y HATA, M ISOMURA, Y TAKAI
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 265 No. 22 p. 13007-13015 1990/08
LOCALIZATION AND SUBCELLULAR-DISTRIBUTION OF SMG P25A, A RAS P21-LIKE GTP-BINDING PROTEIN, IN RAT-BRAIN
A MIZOGUCHI, S KIM, T UEDA, A KIKUCHI, H YORIFUJI, N HIROKAWA, Y TAKAI
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 265 No. 20 p. 11872-11879 1990/07
LOCALIZATION AND SUBCELLULAR-DISTRIBUTION OF SMG P25A, A RAS P21-LIKE GTP-BINDING PROTEIN, IN RAT-BRAIN
A MIZOGUCHI, S KIM, T UEDA, A KIKUCHI, H YORIFUJI, N HIROKAWA, Y TAKAI
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 265 No. 20 p. 11872-11879 1990/07
A GTPASE-ACTIVATING PROTEIN FOR RHOB P20, A RAS P21-LIKE GTP-BINDING PROTEIN - PARTIAL-PURIFICATION, CHARACTERIZATION AND SUBCELLULAR-DISTRIBUTION IN RAT-BRAIN
J YAMAMOTO, A KIKUCHI, T UEDA, N OHGA, Y TAKAI
MOLECULAR BRAIN RESEARCH Vol. 8 No. 2 p. 105-111 1990/07
TISSUE AND SUBCELLULAR DISTRIBUTIONS OF THE SMG-21/RAP1/KREV-1 PROTEINS WHICH ARE PARTLY DISTINCT FROM THOSE OF C-RAS P21S
S KIM, A MIZOGUCHI, A KIKUCHI, Y TAKAI
MOLECULAR AND CELLULAR BIOLOGY Vol. 10 No. 6 p. 2645-2652 1990/06
TISSUE AND SUBCELLULAR DISTRIBUTIONS OF THE SMG-21/RAP1/KREV-1 PROTEINS WHICH ARE PARTLY DISTINCT FROM THOSE OF C-RAS P21S
S KIM, A MIZOGUCHI, A KIKUCHI, Y TAKAI
MOLECULAR AND CELLULAR BIOLOGY Vol. 10 No. 6 p. 2645-2652 1990/06
PURIFICATION AND CHARACTERIZATION FROM BOVINE BRAIN CYTOSOL OF A NOVEL REGULATORY PROTEIN INHIBITING THE DISSOCIATION OF GDP FROM AND THE SUBSEQUENT BINDING OF GTP TO RHOB P20, A RAS P21-LIKE GTP-BINDING PROTEIN
T UEDA, A KIKUCHI, N OHGA, J YAMAMOTO, Y TAKAI
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 265 No. 16 p. 9373-9380 1990/06
A SMALL GTP-BINDING PROTEIN (G-PROTEIN) RECOGNIZED BY SMG P25A GDP DISSOCIATION INHIBITOR (GDI) IN HUMAN PLATELET MEMBRANES AND GDI FOR THIS SMALL G-PROTEIN IN HUMAN PLATELET CYTOSOL
H FUJIOKA, A KIKUCHI, Y YOSHIDA, S KURODA, Y TAKAI
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Vol. 168 No. 3 p. 1244-1252 1990/05
A SMALL GTP-BINDING PROTEIN (G-PROTEIN) RECOGNIZED BY SMG P25A GDP DISSOCIATION INHIBITOR (GDI) IN HUMAN PLATELET MEMBRANES AND GDI FOR THIS SMALL G-PROTEIN IN HUMAN PLATELET CYTOSOL
H FUJIOKA, A KIKUCHI, Y YOSHIDA, S KURODA, Y TAKAI
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Vol. 168 No. 3 p. 1244-1252 1990/05
INHIBITION OF THE RAS-P21 GTPASE-ACTIVATING PROTEIN-STIMULATED GTPASE ACTIVITY OF C-HA-RAS-P21 BY SMG-P21 HAVING THE SAME PUTATIVE EFFECTOR DOMAIN AS RAS-P21S
Y HATA, A KIKUCHI, T SASAKI, MD SCHABER, JB GIBBS, Y TAKAI
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 265 No. 13 p. 7104-7107 1990/05 Article, review, commentary, editorial, etc. (scientific journal)
PURIFICATION AND CHARACTERIZATION FROM BOVINE BRAIN CYTOSOL OF A PROTEIN THAT INHIBITS THE DISSOCIATION OF GDP FROM AND THE SUBSEQUENT BINDING OF GTP TO SMG-P25A, A RAS P21-LIKE GTP-BINDING PROTEIN
T SASAKI, A KIKUCHI, S ARAKI, Y HATA, M ISOMURA, S KURODA, Y TAKAI
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 265 No. 4 p. 2333-2337 1990/02
PURIFICATION AND CHARACTERIZATION FROM BOVINE BRAIN CYTOSOL OF A PROTEIN THAT INHIBITS THE DISSOCIATION OF GDP FROM AND THE SUBSEQUENT BINDING OF GTP TO SMG-P25A, A RAS P21-LIKE GTP-BINDING PROTEIN
T SASAKI, A KIKUCHI, S ARAKI, Y HATA, M ISOMURA, S KURODA, Y TAKAI
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 265 No. 4 p. 2333-2337 1990/02
新生化学実験講座８ 細胞内情報と細胞応答
東京化学同人 1990
ADP-Ribosylating Toxins and G Proteins: Insights into Signal Transduction
American Society for Microbiology 1990
MOLECULAR-CLONING OF SMG-P21B AND IDENTIFICATION OF SMG-P21 PURIFIED FROM BOVINE BRAIN AND HUMAN PLATELETS AS SMG-P21B
Y MATSUI, A KIKUCHI, M KAWATA, J KONDO, Y TERANISHI, Y TAKAI
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Vol. 166 No. 2 p. 1010-1016 1990/01
PURIFICATION AND CHARACTERIZATION FROM BOVINE BRAIN MEMBRANES OF A GTP-BINDING PROTEIN WITH A MR OF 21,000, ADP-RIBOSYLATED BY AN ADP-RIBOSYLTRANSFERASE CONTAMINATED IN BOTULINUM TOXIN TYPE-C1 - IDENTIFICATION AS THE RHOA GENE-PRODUCT
M HOSHIJIMA, J KONDO, A KIKUCHI, K YAMAMOTO, Y TAKAI
MOLECULAR BRAIN RESEARCH Vol. 7 No. 1 p. 9-16 1990/01
Inhibition of the ras p21 GTPase-activating protein-stimulated GTPase activity of c-Ha-ras p21 by smg p21 having the same putative effector domain as ras p21s.
J. Biol. Chem. p. 7104-7107 1990
ADP-Ribosylating Toxins and G Proteins: Insights into Signal Transduction
American Society for Microbiology 1990
MOLECULAR-CLONING OF SMG-P21B AND IDENTIFICATION OF SMG-P21 PURIFIED FROM BOVINE BRAIN AND HUMAN PLATELETS AS SMG-P21B
Y MATSUI, A KIKUCHI, M KAWATA, J KONDO, Y TERANISHI, Y TAKAI
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Vol. 166 No. 2 p. 1010-1016 1990/01
Purification and characterization from bovine brain membranes of a GTP-binding protein with a Mr of 21,000, ADP-ribosylated by an ADP-ribosyltransferase contaminated in botulinum toxin type C1 Identification as the rhoA gene product.
Mol. Brain Res. 1990
【特集】 脳のシンポジウム(第24回) レセプターとその周辺 低分子量G蛋白質とシナプス機能
金成有, 溝口明, 菊池章, 高井義美
神経研究の進歩 Vol. 33 No. 6 p. 940-947 1989/12
SMALL MOLECULAR-WEIGHT GTP-BINDING PROTEINS AND SIGNAL TRANSDUCTION
K YAMAMOTO, T TANIMOTO, S KIM, A KIKUCHI, Y TAKAI
CLINICA CHIMICA ACTA Vol. 185 No. 3 p. 347-356 1989/12
INTRASYNAPTOSOMAL DISTRIBUTION OF THE RAS-25A, RHO-25A AND SMG-25A GTP-BINDING PROTEINS IN BOVINE BRAIN
S KIM, A KIKUCHI, A MIZOGUCHI, Y TAKAI
MOLECULAR BRAIN RESEARCH Vol. 6 No. 2-3 p. 167-176 1989/11
KINETIC-ANALYSIS OF THE BINDING OF GUANINE-NUCLEOTIDES TO BOVINE BRAIN RHOB P20, A RAS P21-LIKE GTP-BINDING PROTEIN
S KURODA, A KIKUCHI, Y TAKAI
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Vol. 163 No. 2 p. 674-681 1989/09
RABBIT INTESTINE CONTAINS A PROTEIN THAT INHIBITS THE DISSOCIATION OF GDP FROM AND THE SUBSEQUENT BINDING OF GTP TO RHOB-P20, A RAS-P21-LIKE GTP-BINDING PROTEIN
N OHGA, A KIKUCHI, T UEDA, J YAMAMOTO, Y TAKAI
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Vol. 163 No. 3 p. 1523-1533 1989/09
PHOSPHORYLATION OF SMG P21, A RAS P21-LIKE GTP-BINDING PROTEIN, BY CYCLIC AMP-DEPENDENT PROTEIN-KINASE IN A CELL-FREE SYSTEM AND IN RESPONSE TO PROSTAGLANDIN-E1 IN INTACT HUMAN-PLATELETS
M KAWATA, A KIKUCHI, M HOSHIJIMA, K YAMAMOTO, E HASHIMOTO, H YAMAMURA, Y TAKAI
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 264 No. 26 p. 15688-15695 1989/09
KINETIC-ANALYSIS OF THE BINDING OF GUANINE-NUCLEOTIDES TO BOVINE BRAIN RHOB P20, A RAS P21-LIKE GTP-BINDING PROTEIN
S KURODA, A KIKUCHI, Y TAKAI
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Vol. 163 No. 2 p. 674-681 1989/09
RABBIT INTESTINE CONTAINS A PROTEIN THAT INHIBITS THE DISSOCIATION OF GDP FROM AND THE SUBSEQUENT BINDING OF GTP TO RHOB-P20, A RAS-P21-LIKE GTP-BINDING PROTEIN
N OHGA, A KIKUCHI, T UEDA, J YAMAMOTO, Y TAKAI
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Vol. 163 No. 3 p. 1523-1533 1989/09
PHOSPHORYLATION OF SMG P21, A RAS P21-LIKE GTP-BINDING PROTEIN, BY CYCLIC AMP-DEPENDENT PROTEIN-KINASE IN A CELL-FREE SYSTEM AND IN RESPONSE TO PROSTAGLANDIN-E1 IN INTACT HUMAN-PLATELETS
M KAWATA, A KIKUCHI, M HOSHIJIMA, K YAMAMOTO, E HASHIMOTO, H YAMAMURA, Y TAKAI
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 264 No. 26 p. 15688-15695 1989/09
細胞生物学 ras p21類似低分子量GTP結合蛋白質とシグナル伝達
松井泰, 菊池章, 高井義美
代謝 Vol. 26 No. Aug p. 101-108 1989/08
KINETIC-ANALYSIS OF THE BINDING OF GUANINE-NUCLEOTIDE TO BOVINE BRAIN SMG-P25A
SHOJI, I, A KIKUCHI, S KURODA, Y TAKAI
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Vol. 162 No. 1 p. 273-281 1989/07
KINETIC-ANALYSIS OF THE BINDING OF GUANINE-NUCLEOTIDE TO BOVINE BRAIN SMG-P25A
SHOJI, I, A KIKUCHI, S KURODA, Y TAKAI
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Vol. 162 No. 1 p. 273-281 1989/07
細胞増殖シグナルと発癌 ras p21類似低分子量GTP結合蛋白質とシグナル伝達
高井義美, 菊池章
癌と化学療法 Vol. 16 No. 3 Pt.2 p. 499-508 1989/03
GTPASE ACTIVATING PROTEINS FOR THE SMG-21 GTP-BINDING PROTEIN HAVING THE SAME EFFECTOR DOMAIN AS THE RAS PROTEINS IN HUMAN-PLATELETS
T UEDA, A KIKUCHI, N OHGA, J YAMAMOTO, Y TAKAI
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Vol. 159 No. 3 p. 1411-1419 1989/03
GTPASE ACTIVATING PROTEINS FOR THE SMG-21 GTP-BINDING PROTEIN HAVING THE SAME EFFECTOR DOMAIN AS THE RAS PROTEINS IN HUMAN-PLATELETS
T UEDA, A KIKUCHI, N OHGA, J YAMAMOTO, Y TAKAI
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Vol. 159 No. 3 p. 1411-1419 1989/03
ras p21類似GTP結合蛋白質smg p25Aの新しい調節蛋白質の精製と性状
荒木伸, 菊池章, 佐々木卓也, 畑裕, 磯村光男, 勝二郁夫, 黒田真也, 高井義美
神経化学 Vol. 28 No. 1 p. 82-83 1989
TISSUE-SPECIFIC EXPRESSION OF A NOVEL GTP-BINDING PROTEIN (SMG-P25A) MESSENGER-RNA AND ITS INCREASE BY NERVE GROWTH-FACTOR AND CYCLIC-AMP IN RAT PHEOCHROMOCYTOMA PC-12 CELLS
K SANO, A KIKUCHI, Y MATSUI, Y TERANISHI, Y TAKAI
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Vol. 158 No. 2 p. 377-385 1989/01
Physiology and Pharmacology of Transmembrane Signalling
Elsevier Science Publishers 1989
The Biology of the Interferon System 1988
Kodansha 1989
Purification and characterization from bovine brain cytosol of two GTPase-activating proteins specific for smg p21, a GTP-binding protein having the same effector domain as c-ras p21s.
J. Biol. Chem. p. 9133-9136 1989
TISSUE-SPECIFIC EXPRESSION OF A NOVEL GTP-BINDING PROTEIN (SMG-P25A) MESSENGER-RNA AND ITS INCREASE BY NERVE GROWTH-FACTOR AND CYCLIC-AMP IN RAT PHEOCHROMOCYTOMA PC-12 CELLS
K SANO, A KIKUCHI, Y MATSUI, Y TERANISHI, Y TAKAI
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Vol. 158 No. 2 p. 377-385 1989/01
Physiology and Pharmacology of Transmembrane Signalling
Elsevier Science Publishers 1989
The Biology of the Interferon System 1988
Kodansha 1989
Purification and characterization from bovine brain cytosol of two GTPase-activating proteins specific for smg p21, a GTP-binding protein having the same effector domain as c-ras p21s.
J. Biol. Chem. p. 9133-9136 1989
SMALL MOLECULAR-WEIGHT GTP-BINDING PROTEINS IN HUMAN-PLATELET MEMBRANES - PURIFICATION AND CHARACTERIZATION OF A NOVEL GTP-BINDING PROTEIN WITH A MOLECULAR-WEIGHT OF 22,000
T OHMORI, A KIKUCHI, K YAMAMOTO, S KIM, Y TAKAI
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 264 No. 3 p. 1877-1881 1989/01
PHOSPHORYLATION BY CYCLIC AMP-DEPENDENT PROTEIN-KINASE OF A HUMAN-PLATELET MR 22,000 GTP-BINDING PROTEIN (SMG P21) HAVING THE SAME PUTATIVE EFFECTOR DOMAIN AS THE RAS GENE-PRODUCTS
M HOSHIJIMA, A KIKUCHI, M KAWATA, T OHMORI, E HASHIMOTO, H YAMAMURA, Y TAKAI
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Vol. 157 No. 3 p. 851-860 1988/12
IDENTIFICATION OF A PLATELET MR 22,000 GTP-BINDING PROTEIN AS THE NOVEL SMG-21 GENE-PRODUCT HAVING THE SAME PUTATIVE EFFECTOR DOMAIN AS THE RAS GENE-PRODUCTS
T OHMORI, A KIKUCHI, K YAMAMOTO, M KAWATA, J KONDO, Y TAKAI
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Vol. 157 No. 2 p. 670-676 1988/12
PHOSPHORYLATION BY CYCLIC AMP-DEPENDENT PROTEIN-KINASE OF A HUMAN-PLATELET MR 22,000 GTP-BINDING PROTEIN (SMG P21) HAVING THE SAME PUTATIVE EFFECTOR DOMAIN AS THE RAS GENE-PRODUCTS
M HOSHIJIMA, A KIKUCHI, M KAWATA, T OHMORI, E HASHIMOTO, H YAMAMURA, Y TAKAI
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Vol. 157 No. 3 p. 851-860 1988/12
IDENTIFICATION OF A PLATELET MR 22,000 GTP-BINDING PROTEIN AS THE NOVEL SMG-21 GENE-PRODUCT HAVING THE SAME PUTATIVE EFFECTOR DOMAIN AS THE RAS GENE-PRODUCTS
T OHMORI, A KIKUCHI, K YAMAMOTO, M KAWATA, J KONDO, Y TAKAI
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Vol. 157 No. 2 p. 670-676 1988/12
GTP結合蛋白質の新しい展開 低分子量G蛋白質
菊池章, 高井義美
実験医学 Vol. 6 No. 12 p. 1157-1164 1988/11
PURIFICATION AND CHARACTERIZATION OF C-KI-RAS P21 FROM BOVINE BRAIN CRUDE MEMBRANES
T YAMASHITA, K YAMAMOTO, A KIKUCHI, M KAWATA, J KONDO, T HISHIDA, Y TERANISHI, H SHIKU, Y TAKAI
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 263 No. 32 p. 17181-17188 1988/11
PURIFICATION AND CHARACTERIZATION OF C-KI-RAS P21 FROM BOVINE BRAIN CRUDE MEMBRANES
T YAMASHITA, K YAMAMOTO, A KIKUCHI, M KAWATA, J KONDO, T HISHIDA, Y TERANISHI, H SHIKU, Y TAKAI
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 263 No. 32 p. 17181-17188 1988/11
ADP-RIBOSYLATION OF THE BOVINE BRAIN RHO-PROTEIN BY BOTULINUM TOXIN TYPE-C1
A KIKUCHI, K YAMAMOTO, T FUJITA, Y TAKAI
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 263 No. 31 p. 16303-16308 1988/11
SMALL MOLECULAR-WEIGHT GTP-BINDING PROTEINS IN HUMAN-ERYTHROCYTE GHOSTS
K IKEDA, A KIKUCHI, Y TAKAI
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Vol. 156 No. 2 p. 889-897 1988/10
SMALL MOLECULAR-WEIGHT GTP-BINDING PROTEINS IN HUMAN-ERYTHROCYTE GHOSTS
K IKEDA, A KIKUCHI, Y TAKAI
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Vol. 156 No. 2 p. 889-897 1988/10
Ca2+作用発現のメカニズム プロテインキナーゼC 受容体とホスホリパーゼCとの共役および脱共役機構
池田和人, 菊池章, 高井義美
蛋白質 核酸 酵素 Vol. 33 No. 12 p. 2166-2174 1988/09
MULTIPLE SMALL MOLECULAR-WEIGHT GTP-BINDING PROTEINS IN BOVINE BRAIN CYTOSOL - PURIFICATION AND CHARACTERIZATION OF A 24KDA PROTEIN
K YAMAMOTO, S KIM, A KIKUCHI, Y TAKAI
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Vol. 155 No. 3 p. 1284-1292 1988/09
MULTIPLE SMALL MOLECULAR-WEIGHT GTP-BINDING PROTEINS IN BOVINE BRAIN CYTOSOL - PURIFICATION AND CHARACTERIZATION OF A 24KDA PROTEIN
K YAMAMOTO, S KIM, A KIKUCHI, Y TAKAI
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Vol. 155 No. 3 p. 1284-1292 1988/09
NUCLEOTIDE AND DEDUCED AMINO-ACID SEQUENCES OF A GTP-BINDING PROTEIN FAMILY WITH MOLECULAR-WEIGHTS OF 25,000 FROM BOVINE BRAIN
Y MATSUI, A KIKUCHI, J KONDO, T HISHIDA, Y TERANISHI, Y TAKAI
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 263 No. 23 p. 11071-11074 1988/08 Article, review, commentary, editorial, etc. (scientific journal)
MODE OF INHIBITORY-ACTION OF CHOLECYSTOKININ IN AMYLASE RELEASE FROM ISOLATED RAT PANCREATIC ACINI - INHIBITION OF SECRETORY PROCESS POST TO PROTEIN KINASE-C-CALCIUM ION SYSTEMS
H NAKANISHI, H OHYANAGI, Y TAKEYAMA, H ONOYAMA, Y SAITOH, A KIKUCHI, Y TAKAI
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Vol. 154 No. 3 p. 1314-1322 1988/08
NUCLEOTIDE AND DEDUCED AMINO-ACID SEQUENCES OF A GTP-BINDING PROTEIN FAMILY WITH MOLECULAR-WEIGHTS OF 25,000 FROM BOVINE BRAIN
Y MATSUI, A KIKUCHI, J KONDO, T HISHIDA, Y TERANISHI, Y TAKAI
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 263 No. 23 p. 11071-11074 1988/08 Article, review, commentary, editorial, etc. (scientific journal)
がん増殖因子とオンコジン Cキナーゼと癌遺伝子産物
貝淵弘三, 菊池章, 福本康夫, 奥尚久, 高井義美
Oncologia Vol. 21 No. 4 p. 24-32 1988/07
Cキナーゼとras p21類似低分子量GTP結合蛋白質
菊池章, 高井義美
実験医学 Vol. 6 No. 5 p. 412-420 1988/05
PURIFICATION AND CHARACTERIZATION OF A NOVEL GTP-BINDING PROTEIN WITH A MOLECULAR-WEIGHT OF 24,000 FROM BOVINE BRAIN MEMBRANES
A KIKUCHI, T YAMASHITA, M KAWATA, K YAMAMOTO, K IKEDA, T TANIMOTO, Y TAKAI
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 263 No. 6 p. 2897-2904 1988/02
Progress in Endocrinology
Elsevier Science Publishers 1988
Progress in Endocrinology
Elsevier Science Publishers 1988
MODES OF INHIBITORY-ACTION OF PROTEIN-KINASE-C IN THE CHEMOTACTIC PEPTIDE-INDUCED FORMATION OF INOSITOL PHOSPHATES IN DIFFERENTIATED HUMAN-LEUKEMIC (HL-60) CELLS
A KIKUCHI, K IKEDA, O KOZAWA, Y TAKAI
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 262 No. 14 p. 6766-6770 1987/05
INVOLVEMENT OF A GUANINE NUCLEOTIDE-BINDING PROTEIN IN COUPLING OF RECEPTORS TO PHOSPHOLIPASE C-MEDIATED PHOSPHOINOSITIDE HYDROLYSIS
Y TAKAI, A KIKUCHI, O KOZAWA
CELL STRUCTURE AND FUNCTION Vol. 11 No. 4 p. 396-396 1986/12 Research paper, summary (international conference)
INHIBITION OF CHEMOTACTIC PEPTIDE-INDUCED PHOSPHOINOSITIDE HYDROLYSIS BY PHORBOL ESTERS THROUGH THE ACTIVATION OF PROTEIN-KINASE-C IN DIFFERENTIATED HUMAN-LEUKEMIA (HL-60) CELLS
A KIKUCHI, O KOZAWA, Y HAMAMORI, K KAIBUCHI, Y TAKAI
CANCER RESEARCH Vol. 46 No. 7 p. 3401-3406 1986/07
FORMATION OF A PHORBOL ESTER-BINDING FRAGMENT FROM PROTEIN-KINASE-C BY PROTEOLYTIC DIGESTION
M HOSHIJIMA, A KIKUCHI, T TANIMOTO, K KAIBUCHI, Y TAKAI
CANCER RESEARCH Vol. 46 No. 6 p. 3000-3004 1986/06
Gunma Symposia on Endocrinology: Molecular Mechanism of Biosignal Transduction
Center for Academic Publications Japan 1986
Direct evidence for involvement of a guanine nucleotide-binding protein in chemotactic peptide-stimulated formation of inositol bisphosphate and trisphosphate in differentiated human leukemic (HL-60)cells
KIKUCHI A.
J. Biol. Chem. Vol. 261 p. 11558-11562 1986
Gunma Symposia on Endocrinology: Molecular Mechanism of Biosignal Transduction
Center for Academic Publications Japan 1986
Direct evidence for involvement of a guanine nucleotide-binding protein in chemotactic peptide-stimulated formation of inositol bisphosphate and trisphosphate in differentiated human leukemic (HL-60) cells Reconstitution with Gi or Go of the plasma mem・・・
J. Biol. Chem. p. 11558-11562 1986
POSSIBLE INVOLVEMENT OF PROTEIN-KINASE-C AND CALCIUM-ION IN GROWTH FACTOR-INDUCED EXPRESSION OF C-MYC ONCOGENE IN SWISS 3T3-FIBROBLASTS
K KAIBUCHI, T TSUDA, A KIKUCHI, T TANIMOTO, T YAMASHITA, Y TAKAI
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 261 No. 3 p. 1187-1192 1986/01
ROLE OF PROTEIN-KINASE-C AND CALCIUM-ION IN THE MITOGENIC ACTION OF GROWTH-FACTORS
Y TAKAI, K KAIBUCHI, T TSUDA, A KIKUCHI, T TANIMOTO, T YAMASHITA
CELL STRUCTURE AND FUNCTION Vol. 10 No. 4 p. 441-441 1985/12 Research paper, summary (international conference)
免疫応答の化学的アプローチ Cキナーゼとリンパ球の増殖制御機構
菊池章, 貝淵弘三, 高井義美
代謝 Vol. 22 No. 11 p. 1525-1535 1985/11/24
ENHANCEMENT OF COLLAGEN-INDUCED PHOSPHOINOSITIDE TURNOVER BY THROMBOXANE-A2 ANALOG THROUGH CA-2+ MOBILIZATION IN HUMAN-PLATELETS
K KAIBUCHI, T TSUDA, A KIKUCHI, T TANIMOTO, Y TAKAI
FEBS LETTERS Vol. 192 No. 1 p. 104-108 1985
ISOLATION AND PROPERTIES OF CASEIN KINASES FROM HUMAN-PLATELETS
A KIKUCHI, S TOMISAKA, K YONEZAWA, A SANO, H YAMAMURA
BIOMEDICAL RESEARCH-TOKYO Vol. 3 No. 5 p. 477-481 1982
細胞
先端医学社 2001
遺伝子医学
メディカルドウ 2001
実験医学
羊土社 2000
細胞工学
秀潤社 2000
シグナル伝達ネットワーク
東京化学同人 2000
分子細胞治療
先端医学社 2000
Molecular Medicine
中山書店 2000
Molecular Medicine
2000
別冊・医学のあゆみ 神経疾患
医歯薬出版 1999
G.I. Research
先端医学社 1999
G.I. Research
1999
神経伝達物質update
中外医学社 1998
実験医学
羊土社 1998
実験医学
羊土社 1996
生化学
日本生化学会 1996
実験医学
羊土社 1994
生化学
日本生化学会 1992
実験医学
羊土社 1992
リピドバイオファクター
化学同人 1992
皮膚科紀要
日本皮膚科学会 1991
実験医学
羊土社 1991
細胞科学
1991
日本内分泌学会誌
日本内分泌学会 1991
実験医学
羊土社 1990
病態代謝
病態代謝研究会 1990
実験医学
羊土社 1989
神経研究の進歩
1989
病態生理
1989
癌と化学療法
1989
セラピテック・リサーチ
1988
医学のあゆみ
医歯薬出版 1988
蛋白質核酸酵素
共立出版社 1988
実験医学
羊土社 1988
癌と化学療法
1986
代謝 免疫 85
中山書店 1985
DKK1-CKAP4シグナルは肝癌の予後不良因子であり、CKAP4は新たな治療標的となりうる
井口 浩輔, 権 英寿, 木村 公一, 松本 真司, 福本 巧, 菊池 章
日本癌学会総会記事 2020/10
RAS下流のエフェクター分子であるARL4Cの浸潤突起先端部への局在が膵癌の浸潤転移を制御する
原田 昭和, 松本 真司, 菊池 章
日本癌学会総会記事 2020/10
大腸がんの診断・治療と発がん研究における新しい知見 炎症を伴った大腸がんにおけるWnt5aシグナルの役割
菊池 章
日本癌学会総会記事 2020/10
分子発がん研究:その足跡と未来(24年の歩み) Wntシグナルと分子標的治療
菊池 章
日本癌学会総会記事 2020/10
Wntシグナル標的遺伝子GREB1によるTGFβシグナルの抑制を介した肝芽腫形成の制御
松本 真司, 山道 拓, 新沢 康英, 奥山 宏臣, 菊池 章
日本生化学会大会プログラム・講演要旨集 2020/09
悪性黒色腫におけるGREB1 isoform 4の発現機構解析と治療への応用
新沢 康英, 松本 真司, 種村 篤, 藤本 学, 菊池 章
日本生化学会大会プログラム・講演要旨集 2020/09
アネキシンA2によるDKK1受容体CKAP4の細胞膜への輸送制御
山本 英樹, 佐田 遼太, 菊池 章
日本生化学会大会プログラム・講演要旨集 2020/09
パルミトイル化CKAP4はVDAC2を介してミトコンドリア機能を制御する
原田 武志, 佐田 遼太, 大杉 祥仁, 松本 真司, 菊池 章
日本生化学会大会プログラム・講演要旨集 2020/09
グルカゴンの線維形成中のグルカゴン含有リン脂質二重膜の形態的変化の31Pと13Cを用いた解明(Morphological changes of glucagon-phospholipid bilayers during fibril formation of glucagon as revealed by 31P and 13C solid-state NMR)
内藤 晶, 羽矢 和未, 槇野 義輝, 菊池 章恵[木下], 川村 出
日本生化学会大会プログラム・講演要旨集 2020/09
サンドイッチELISA法を用いた肺がん患者における血清CKAP4タンパク濃度の測定
名越 章裕, 佐田 遼太, 木村 公一, 山本 英樹, 菊池 章
日本生化学会大会プログラム・講演要旨集 2020/09
肝細胞がんにおけるWnt標的遺伝子GREB1の発現と細胞増殖制御
瀬田 みなみ, 松本 真司, 福本 巧, 菊池 章
日本生化学会大会プログラム・講演要旨集 2020/09
Dickkopf1とFOXM1のポジティブフィードバックループは膵臓癌と食道癌の増殖と関連している(The Dickkopf1 and FOXM1 positive feedback loop is associated with tumor growth of pancreatic and esophageal cancer)
佐田 遼太, 高田 直季, 木村 公一, 菊池 章
日本生化学会大会プログラム・講演要旨集 2020/09
肝芽腫におけるWntシグナル関連新規創薬標的GREB1の同定と核酸医薬の開発
山道 拓, 松本 真司, 奥山 宏臣, 菊池 章
日本小児血液・がん学会雑誌 2020/09
Wntシグナル研究の歴史と展望 その足跡と未来
菊池 章
生化学 2020/08
DKK1-CKAP4シグナルと転写因子FOXM1のpositive feedback loop形成機構
高田 直季, 木村 公一, 菊池 章
第42回日本分子生物学会年会 2019/12
DKK1受容体CKAP4のパルミチン酸化を介したシグナル制御機構
佐田 遼太, 木村 公一, 山本 英樹, 菊池 章
第42回日本分子生物学会年会 2019/12
肝腫瘍に対するARL4Cを標的としたアンチセンス核酸を用いた新規がん治療法の開発
原田 武志, 松本 真司, 廣田 傑, 木村 公一, 藤井 慎介, 菊池 章
日本生化学会大会プログラム・講演要旨集 2019/09
DKK1受容体であるCKAP4とLRP6の動的パルミチン酸化は細胞膜マイクロドメイン局在を誘導しDKK1シグナルを制御する(Dynamic palmitoylation determines membrane microdomain localization of two DKK1 receptors CKAP4 and LRP6, and regulates DKK1 signaling)
山本 英樹, 佐田 遼太, 木村 公一, 菊池 章
日本生化学会大会プログラム・講演要旨集 2019/09
新規Wntシグナル標的遺伝子によるTGFβシグナルの抑制を介した肝芽腫形成の制御
松本 真司, 山道 拓, 新沢 康英, 奥山 宏臣, 菊池 章
日本生化学会大会プログラム・講演要旨集 2019/09
肝腫瘍に対するARL4Cを標的としたアンチセンス核酸を用いた新規がん治療法の開発
原田 武志, 松本 真司, 廣田 傑, 木村 公一, 藤井 慎介, 菊池 章
日本生化学会大会プログラム・講演要旨集 2019/09
細胞・組織動態解析と数理モデルで解く形態形成の原理 オルガノイドと数理モデルで迫る形態形成の仕組み
麓 勝己, 今村 寿子, 隅山 健太, 吉村 成弘, 菊池 章
日本生化学会大会プログラム・講演要旨集 2019/09
固体13C-NMRによる脂質膜存在下でのグルカゴンの線維形成機構の解析
内藤 晶, 山根 衣寿美, 百瀬 綾乃, 藤田 英樹, 吉本 瑛梨, 菊池 章江[木下], 川村 出
日本生化学会大会プログラム・講演要旨集 2019/09
Arl4cを標的とした新規肺腺癌治療薬の開発(Development of a novel therapeutic agent for lung adenocarcinoma targeting Arl4c)
木村 賢二, 松本 真司, 新谷 康, 菊池 章
日本癌学会総会記事 2019/09
DKK1新規受容体CKAP4は膵臓癌由来のエクソソームのバイオマーカーとがん治療の分子標的になる(CKAP4, a DKK1 receptor, is a biomarker in exosomes derived from pancreatic cancer and a molecular target for therapy)
山本 英樹, 木村 公一, 菊池 章
日本癌学会総会記事 2019/09
膵癌細胞の腫瘍浸潤におけるArl4c-IQGAP1の相互作用(Roles of Arl4c-IQGAP1 interaction in tumor invasion of pancreatic cancer cells)
原田 昭和, 松本 真司, 菊池 章
日本癌学会総会記事 2019/09
WntシグナルはTGFβシグナルを抑制することにより肝芽腫の腫瘍形成を促進する(A novel therapeutic target of Wnt signaling promotes the development of hepatoblastoma by suppressing TGFβ signaling)
山道 拓, 松本 真司, 奥山 宏臣, 菊池 章
日本癌学会総会記事 2019/09
DKK1 signal-dependent cellular functions through two receptors, LRP6 and CKAP4.
2019/06
CKAP4の動的なパルミチン酸化修飾は癌細胞の膜マイクロドメイン形成と増殖シグナル伝達活性を調節する(Dynamic palmitoylation regulates membrane microdomain localization and cancer cell proliferative signaling activity of CKAP4)
佐田 遼太, 木村 公一, 山本 英樹, 菊池 章
日本生化学会大会プログラム・講演要旨集 2018/09
DKK1の新規受容体であるCKAP4のエクソソームへの移行機構の解析
木村 公一, 菊池 章
日本生化学会大会プログラム・講演要旨集 2018/09
がん特性の解明に迫るシグナル伝達研究 新規がんシグナルDickkopf1-CKAP4経路は、がん治療のための分子標的となる(Signal transduction analysis for cancer profiling The Dickkopf1-CKAP4 pathway, a novel cancer signaling, represents molecular targets for cancer therapy)
菊池 章, 木村 公一, 麓 勝己
日本癌学会総会記事 2018/09
The DKK1-CKAP4 signaling pathway as a novel therapeutic target for cancers.
Kimura H, Fumoto K, Kikuchi A
Australia Japan Medical Research Symposium 2018/09
唾液腺におけるWntシグナル依存性新規前駆細胞の同定と機能解析
松本真司, 廣田傑, 廣田傑, 菊池章
Journal of Oral Biosciences Supplement (Web) 2018
CKAP4の脂質修飾を介する機能制御
佐田 遼太, 木村 公一, 麓 勝己, 山本 英樹, 菊池 章
生命科学系学会合同年次大会 2017/12
DickkopfファミリーによるCKAP4を介したがん細胞増殖調節機構
梶原 千裕, 麓 勝巳, 木村 公一, 菊池 章
生命科学系学会合同年次大会 2017/12
Wnt Signaling Induces Factor X to Promote Tumorigenesis of Hepatoblastoma
Taku Yamamichi, Shinji Matsumoto, Akira Kikuchi, Hiroomi Okuyama
PEDIATRIC BLOOD & CANCER 2017/11
食道扁平上皮癌の新規治療標的であるDKK1-CKAP4シグナル
木村 公一, 新野 直樹, 佐田 遼太, 麓 勝己, 菊池 章
日本癌学会総会記事 2017/09
がん分子標的治療薬の分子基盤と臨床応用 DKK1の新規受容体CKAP4を標的とする抗がん剤開発
菊池 章, 木村 公一, 麓 勝己, 大杉 祥仁
日本癌学会総会記事 2017/09
膵癌の新規治療標的であるDkk1新規受容体CKAP4
木村 公一, 麓 勝己, 庄島 健作, 大杉 祥仁, 菊池 章
膵臓 2017/05
CKAP4の翻訳後修飾を介する機能制御
佐田遼太, 木村公一, 麓勝己, 菊池章
第64回日本生化学会 近畿支部例会 2017/05
腸管炎症関連疾患におけるWnt5aの機能解析
前原奈都美, 佐藤朗, 麓勝己, 菊池章
日本生化学会大会(Web) 2017
細胞におけるシグナル系の役割の検討 第一製薬(株）
がん遺伝子産物Rasと関連する分子を用いた新しいがんの遺伝子診断キットの開発 広島県産業技術振興機構地域研究開発促進拠点支援事業
CKAP4-MOLECULAR-TARGETED ANTI-TUMOR AGENT
1061895号
出願日:2017/08/25
登録日:2020/04/14
CKAP4を標的分子とした抗腫瘍剤
菊池 章, 麓 勝己, 木村 公一
特許第6316498号
出願日:2016/01/28
登録日:2018/04/06
Antisense Oligonucleotide Targeting ARL4C Molecule, And Nucleic Acid Drug Using Antisense Oligonucleotide
WO2020-050307
出願日:2021/03/04
抗CKAP4モノクローナル抗体
菊池 章, 麓 勝己, 木村 公一
PCT/JP2018/035719
WO2019-065747
出願日:2018/09/26
CKAP4を標的とした抗腫瘍剤
菊池 章, 麓 勝己, 木村 公一
2017090701503100(CN)
2017090701503100(CN)
出願日:2017/09
CKAP4を標的とした抗腫瘍剤
菊池 章, 麓 勝己, 木村 公一
16755122.5 (EP)
16755122.5 (EP)
出願日:2017/09
CKAP4を標的分子とした抗腫瘍剤
菊池 章, 麓 勝己, 木村 公一
WO2016-136372
出願日:2016/01/28
CKAP4を標的分子とした抗腫瘍剤
菊池 章, 麓 勝己, 木村 公一
出願日:2018/03/27
癌治療用医薬組成物
菊池 章, 松本 真司, 藤井 慎介
出願日:2014/09/19
Antisense Oligonucleotide Targeting ARL4C Molecule, And Nucleic Acid Drug Using Antisense Oligonucleotide
出願日:2021/03/04
性ホルモン非感受性GREB1陽性腫瘍の治療剤
菊池章, 松本真司, 山道拓
出願日:2020/05/22
ANTI-CKAP4 MONOCLONAL ANTIBODY
出願日:2020/04/06
ANTI-CKAP4 MONOCLONAL ANTIBODY
出願日:2020/03/24
ARL4Cを標的分子とするアンチセンスオリゴヌクレオチド、及び当該アンチセンスオリゴヌクレオチドを使用した核酸医薬
菊池章, 松本真司, 小比賀聡, 笠原勇矢, 福本功
出願日:2019/09/04
