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CLEMENT ANGKAWIDJAJA

CLEMENT ANGKAWIDJAJA

Associate Professor

Research Areas

  • Life sciences, Structural biochemistry

Papers

  • Affinity shift of ATP upon glycerol binding to a glycerol kinase from the hyperthermophilic archaeon Thermococcus kodakarensis KOD1, Hokao Ryuta,Matsumura Hiroyoshi,Katsumi Ryota,Angkawidjaja Clement,Takano Kazufumi,Kanaya Shigenori,Koga Yuichi, Journal of bioscience and bioengineering, Society for Biotechnology, Vol. 129, No. 6, p. 657-663, 2020/06
  • Crystal structure of the Fab region of a neutralizing antibody against granulocyte-macrophage colony-stimulating factor., Clement Angkawidjaja,Takashi Torashima, Acta crystallographica. Section F, Structural biology communications, Vol. 75, No. Pt 10, p. 634-639, 2019/10/01
  • Structural Basis for the Serratia marcescens Lipase Secretion System: Crystal Structures of the Membrane Fusion Protein and Nucleotide-Binding Domain., Daichi Murata,Hiroyuki Okano,Clement Angkawidjaja,Masato Akutsu,Shun-Ichi Tanaka,Kenyu Kitahara,Takuya Yoshizawa,Hiroyoshi Matsumura,Yuji Kado,Eiichi Mizohata,Tsuyoshi Inoue,Satoshi Sano,Yuichi Koga,Shigenori Kanaya,Kazufumi Takano, Biochemistry, AMER CHEMICAL SOC, Vol. 56, No. 47, p. 6281-6291, 2017/11/28
  • Structure, activity, and stability of metagenome-derived glycoside hydrolase family 9 endoglucanase with an N-terminal Ig-like domain., Hiroyuki Okano,Eiko Kanaya,Masashi Ozaki,Clement Angkawidjaja,Shigenori Kanaya, Protein science : a publication of the Protein Society, Vol. 24, No. 3, p. 408-19, 2015/03
  • Structural and biochemical characterization of a metagenome-derived esterase with a long N-terminal extension., Hiroyuki Okano,Xun Hong,Eiko Kanaya,Clement Angkawidjaja,Shigenori Kanaya, Protein science : a publication of the Protein Society, Vol. 24, No. 1, p. 93-104, 2015/01
  • Rational design of a glycosynthase by the crystal structure of β-galactosidase from Bacillus circulans (BgaC) and its use for the synthesis of N-acetyllactosamine type 1 glycan structures., Manja Henze,Dong-Ju You,Claudia Kamerke,Natalie Hoffmann,Clement Angkawidjaja,Sabrina Ernst,Jörg Pietruszka,Shigenori Kanaya,Lothar Elling, Journal of biotechnology, Vol. 191, p. 78-85, 2014/12/10
  • Structural basis for salt-dependent folding of ribonuclease H1 from halophilic archaeon Halobacterium sp. NRC-1., Dong-Ju You,Nujarin Jongruja,Elias Tannous,Clement Angkawidjaja,Yuichi Koga,Shigenori Kanaya, Journal of structural biology, Vol. 187, No. 2, p. 119-128, 2014/08
  • Calcium-independent opening of lid1 of a family I.3 lipase by a single Asp to Arg mutation at the calcium-binding site., M Cheng,C Angkawidjaja,Y Koga,S Kanaya, Protein engineering, design & selection : PEDS, Vol. 27, No. 5, p. 169-76, 2014/05
  • Structural and mechanistic insights into the kynurenine aminotransferase-mediated excretion of kynurenic acid., Ken Okada,Clement Angkawidjaja,Yuichi Koga,Shigenori Kanaya, Journal of structural biology, Vol. 185, No. 3, p. 257-66, 2014/03
  • Structure and stability of metagenome-derived glycoside hydrolase family 12 cellulase (LC-CelA) a homolog of Cel12A from Rhodothermus marinus., Hiroyuki Okano,Masashi Ozaki,Eiko Kanaya,Joong-Jae Kim,Clement Angkawidjaja,Yuichi Koga,Shigenori Kanaya, FEBS open bio, Vol. 4, p. 936-46, 2014
  • Formation of the high-affinity calcium binding site in pro-subtilisin E with the insertion sequence IS1 of pro-Tk-subtilisin., Ryo Uehara,Clement Angkawidjaja,Yuichi Koga,Shigenori Kanaya, Biochemistry, AMER CHEMICAL SOC, Vol. 52, No. 50, p. 9080-8, 2013/12/17
  • Role of N-terminal extension of Bacillus stearothermophilus RNase H2 and C-terminal extension of Thermotoga maritima RNase H2., Etin-Diah Permanasari,Clement Angkawidjaja,Yuichi Koga,Shigenori Kanaya, The FEBS journal, WILEY-BLACKWELL, Vol. 280, No. 20, p. 5065-79, 2013/10
  • Crystallization and X-ray structure determination of a thermoalkalophilic lipase from Geobacillus SBS-4S., Muhammad Tayyab,Naeem Rashid,Clement Angkawidjaja,Shigenori Kanaya,Muhammad Akhtar, Acta crystallographica. Section F, Structural biology and crystallization communications, Vol. 69, No. Pt 4, p. 355-7, 2013/04/01
  • Accelerated maturation of Tk-subtilisin by a Leu -> Promutation at the C-terminus of the propeptide, which reduces the binding of the propeptide to Tk-subtilisin, Ryo Uehara,Yasunori Ueda,Dong-Ju You,Yuichi Koga,Shigenori Kanaya, FEBS JOURNAL, WILEY-BLACKWELL, Vol. 280, No. 4, p. 994-1006, 2013/02
  • Requirement of lid2 for interfacial activation of a family I.3 lipase with unique two lid structures., Maria Cheng,Clement Angkawidjaja,Yuichi Koga,Shigenori Kanaya, The FEBS journal, Vol. 279, No. 19, p. 3727-3737, 2012/10
  • Structure and stability of a thermostable carboxylesterase from the thermoacidophilic archaeon Sulfolobus tokodaii., Clement Angkawidjaja,Yuichi Koga,Kazufumi Takano,Shigenori Kanaya, The FEBS journal, WILEY-BLACKWELL, Vol. 279, No. 17, p. 3071-84, 2012/09
  • Structure and characterization of RNase H3 from Aquifex aeolicus., Nujarin Jongruja,Dong-Ju You,Clement Angkawidjaja,Eiko Kanaya,Yuichi Koga,Shigenori Kanaya, The FEBS journal, WILEY-BLACKWELL, Vol. 279, No. 15, p. 2737-53, 2012/08
  • Activity, stability, and structure of metagenome-derived LC11-RNase H1, a homolog of Sulfolobus tokodaii RNase H1., Tri-Nhan Nguyen,Clement Angkawidjaja,Eiko Kanaya,Yuichi Koga,Kazufumi Takano,Shigenori Kanaya, Protein science : a publication of the Protein Society, WILEY-BLACKWELL, Vol. 21, No. 4, p. 553-61, 2012/04
  • Role of polar and nonpolar residues at the active site for PPIase activity of FKBP22 from Shewanella sp. SIB1., Cahyo Budiman,Takashi Tadokoro,Clement Angkawidjaja,Yuichi Koga,Shigenori Kanaya, The FEBS journal, Vol. 279, No. 6, p. 976-86, 2012/03
  • Ca2+ regulates the Drosophila Stoned-A and Stoned-B proteins interaction with the C2B domain of Synaptotagmin-1., Carolina Soekmadji,Clement Angkawidjaja,Leonard E Kelly, PloS one, Vol. 7, No. 6, 2012
  • Characteristic features of kynurenine aminotransferase allosterically regulated by (alpha)-ketoglutarate in cooperation with kynurenine., Ken Okada,Clement Angkawidjaja,Yuichi Koga,Kazufumi Takano,Shigenori Kanaya, PloS one, Vol. 7, No. 7, 2012
  • Crystal structure of N-domain of FKBP22 from Shewanella sp. SIB1: dimer dissociation by disruption of Val-Leu knot., Cahyo Budiman,Clement Angkawidjaja,Hideki Motoike,Yuichi Koga,Kazufumi Takano,Shigenori Kanaya, Protein science : a publication of the Protein Society, WILEY-BLACKWELL, Vol. 20, No. 10, p. 1755-64, 2011/10
  • Identification of the substrate binding site in the N-terminal TBP-like domain of RNase H3., Seiko Miyashita,Takashi Tadokoro,Clement Angkawidjaja,Dong-Ju You,Yuichi Koga,Kazufumi Takano,Shigenori Kanaya, FEBS letters, ELSEVIER SCIENCE BV, Vol. 585, No. 14, p. 2313-7, 2011/07/21
  • Importance of an extreme C-terminal motif of a family I.3 lipase for stability., K Kuwahara,C Angkawidjaja,Y Koga,K Takano,S Kanaya, Protein engineering, design & selection : PEDS, OXFORD UNIV PRESS, Vol. 24, No. 5, p. 411-8, 2011/05
  • Highly active metallocarboxypeptidase from newly isolated Geobacillus strain SBS-4S : Cloning and characterization, TAYYAB Muhammad,RASHID Naeem,ANGKAWIDJAJA Clement,KANAYA Shigenori,AKHTAR Muhammad, Journal of bioscience and bioengineering, The Society for Biotechnology, Japan, Vol. 111, No. 3, p. 259-265, 2011/03/25
  • Stabilization by fusion to the C-terminus of hyperthermophile Sulfolobus tokodaii RNase HI: a possibility of protein stabilization tag., Kazufumi Takano,Tomohiro Okamoto,Jun Okada,Shun-ichi Tanaka,Clement Angkawidjaja,Yuichi Koga,Shigenori Kanaya, PloS one, PUBLIC LIBRARY SCIENCE, Vol. 6, No. 1, 2011/01/19
  • Crystal structure of stable protein CutA1 from psychrotrophic bacterium Shewanella sp. SIB1., Aya Sato,Sonoko Yokotani,Takashi Tadokoro,Shun-ichi Tanaka,Clement Angkawidjaja,Yuichi Koga,Kazufumi Takano,Shigenori Kanaya, Journal of synchrotron radiation, WILEY-BLACKWELL PUBLISHING, INC, Vol. 18, No. 1, p. 6-10, 2011/01
  • Protein core adaptability: crystal structures of the cavity-filling variants of Escherichia coli RNase HI., Masaki Tanaka,Hyongi Chon,Clement Angkawidjaja,Yuichi Koga,Kazufumi Takano,Shigenori Kanaya, Protein and peptide letters, BENTHAM SCIENCE PUBL LTD, Vol. 17, No. 9, p. 1163-9, 2010/09
  • Crystal structure of a subtilisin homologue, Tk-SP, from Thermococcus kodakaraensis: requirement of a C-terminal beta-jelly roll domain for hyperstability., Tita Foophow,Shun-ichi Tanaka,Clement Angkawidjaja,Yuichi Koga,Kazufumi Takano,Shigenori Kanaya, Journal of molecular biology, ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, Vol. 400, No. 4, p. 865-77, 2010/07/23
  • X-ray crystallographic and MD simulation studies on the mechanism of interfacial activation of a family I.3 lipase with two lids., Clement Angkawidjaja,Hiroyoshi Matsumura,Yuichi Koga,Kazufumi Takano,Shigenori Kanaya, Journal of molecular biology, ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, Vol. 400, No. 1, p. 82-95, 2010/07/02
  • Engineering of monomeric FK506-binding protein 22 with peptidyl prolyl cis-trans isomerase. Importance of a V-shaped dimeric structure for binding to protein substrate., Cahyo Budiman,Keisuke Bando,Clement Angkawidjaja,Yuichi Koga,Kazufumi Takano,Shigenori Kanaya, The FEBS journal, WILEY-BLACKWELL, Vol. 276, No. 15, p. 4091-101, 2009/08
  • Destabilization of psychrotrophic RNase HI in a localized fashion as revealed by mutational and X-ray crystallographic analyses., Muhammad S Rohman,Takashi Tadokoro,Clement Angkawidjaja,Yumi Abe,Hiroyoshi Matsumura,Yuichi Koga,Kazufumi Takano,Shigenori Kanaya, The FEBS journal, WILEY-BLACKWELL PUBLISHING, INC, Vol. 276, No. 2, p. 603-13, 2009/01
  • Importance of the Ca2+-binding sites in the N-catalytic domain of a family I.3 lipase for activity and stability., K Kuwahara,C Angkawidjaja,H Matsumura,Y Koga,K Takano,S Kanaya, Protein engineering, design & selection : PEDS, OXFORD UNIV PRESS, Vol. 21, No. 12, p. 737-44, 2008/12
  • Crystal structure of a family I.3 lipase from Pseudomonas sp. MIS38 in a closed conformation., Clement Angkawidjaja,Dong-ju You,Hiroyoshi Matsumura,Katsumasa Kuwahara,Yuichi Koga,Kazufumi Takano,Shigenori Kanaya, FEBS letters, Vol. 581, No. 26, p. 5060-4, 2007/10/30
  • Extracellular overproduction and preliminary crystallographic analysis of a family I.3 lipase., Clement Angkawidjaja,Dong-Ju You,Hiroyoshi Matsumura,Yuichi Koga,Kazufumi Takano,Shigenori Kanaya, Acta crystallographica. Section F, Structural biology and crystallization communications, Vol. 63, No. Pt 3, p. 187-9, 2007/03/01
  • Family I.3 lipase: bacterial lipases secreted by the type I secretion system., C Angkawidjaja,S Kanaya, Cellular and molecular life sciences : CMLS, Vol. 63, No. 23, p. 2804-17, 2006/12
  • Extracellular secretion of Escherichia coli alkaline phosphatase with a C-terminal tag by type I secretion system: purification and biochemical characterization., C Angkawidjaja,K Kuwahara,K Omori,Y Koga,K Takano,S Kanaya, Protein engineering, design & selection : PEDS, Vol. 19, No. 7, p. 337-43, 2006/07
  • Importance of a repetitive nine-residue sequence motif for intracellular stability and functional structure of a family I.3 lipase., Clement Angkawidjaja,Aditya Paul,Yuichi Koga,Kazufumi Takano,Shigenori Kanaya, FEBS letters, Vol. 579, No. 21, p. 4707-12, 2005/08/29

Misc.

  • 2Cp12 Evolvability of thermophilic proteins from Archaea and Bacteria, Aoi Atsushi,Angkawidjaja Clement,Koga Yuichi,Takano Kazufumi,Kanaya Shigenori, Vol. 64, p. 41-41, 2012
  • 2Cp14 Study of novel metagenome-derived esterase from leaf-and-branch compost, Okano Hiroyuki,Hong Xun,Yamato Saya,Kanaya Eiko,You Dong-Ju,Angkawidjaja Clement,Koga Yuichi,Kanaya Shigenori, Vol. 64, p. 42-42, 2012
  • 2Cp21 Activity and Stability of an Artificial Protein with Two Tandemly-linked RNase H Molecules, Takamiya Takashi,Kanaya Eiko,Angkawidjaja Clement,You Dong-Ju,Takano Kazufumi,Koga Yuichi,Kanaya Shigenori, Vol. 64, p. 43-43, 2012
  • 2Cp24 Analysis of molecular mechanism for enantioselectivity of lipase from Burkholderia cepacia KWI-56, Hatanaka Akitomo,Fukuda Hiroyuki,You Dong-Ju,Angkawidjaja Clement,Koga Yuichi,Kanaya Shigenori, Vol. 64, p. 44-44, 2012
  • 4Cp18 Crystal structure of a metagenome-derived homolog of Sulfolobus tokodaii RNase H1 :, Nguyen Tri-Nhan,Angkawidjaja Clement,Matsumoto Hiroyuki,You Dong-Ju,Koga Yuichi,Kanaya Shigenori, Vol. 64, p. 199-199, 2012
  • 2つの同一ドメインを分子内に持つ人工タンパク質の安定性と活性, 高宮 毅志,金谷 栄子,Angkawidjaja Clement,劉 東周,古賀 雄一,高野 和文,金谷 茂則, 日本生化学会大会プログラム・講演要旨集, (公社)日本生化学会, Vol. 84回, p. 2P-0170, 2011/09
  • Thermococcus kodakaraensis由来のサブチリシン相同体であるTk-SPの安定性にCa2+イオンが果たす役割(Role of the Ca2+ ions for stability of subtilisin homologue, Tk-SP, from Thermococcus kadakaraensis), Nitat Sinsereekul,Foophow Tita,Angkawidjaja Clement,Koga Yuichi,Takano Kazufumi,Kanaya Shigenori, 日本生化学会大会プログラム・講演要旨集, (公社)日本生化学会, Vol. 84回, p. 2P-0531, 2011/09
  • LipBのATP結合ドメインの構造機能解析, 岡野 啓志,中村 仁美,Angkawidjaja Clement,古賀 雄一,高野 和文,金谷 茂則, 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, (公社)日本生化学会, Vol. 83回・33回, p. 2P-0016, 2010/12
  • Antioxidant and DNA Damage Prevention Activities of the Edible Parts of Gnetum gnemon and Their Changes upon Heat Treatment, SANTOSO Martha,NAKA Yuko,ANGKAWIDJAJA Clement,YAMAGUCHI Tomoko,MATOBA Teruyoshi,TAKAMURA Hitoshi, Food Science and Technology Research, Japanese Society for Food Science and Technology, Vol. 16, No. 6, p. 549-556, 2010/11/01
  • Arg142とPhe197はシュワネラ種SIB1由来FKBP22のプロリルイソメラーゼ活性に重要である(Importance of Arg142 and Phe197 for Prolyl Isomerase Activity of FKBP22 from Shewanella sp. SIB1), ブディマン・チャヒヨ,田所 高志,アンカウィジャヤ・クレメン,古賀 雄一,高野 和文,金谷 茂則, 日本生化学会大会プログラム・講演要旨集, (公社)日本生化学会, Vol. 82回, p. 2P-417, 2009/09
  • 1P-020 Mechanism of Interfacial Activation of a Family I.3 Lipase with Two Lid Structures Revealed by X-ray Crystallography and Molecular Dynamics Simulation(Protein:Structure & Function, The 47th Annual Meeting of the Biophysical Society of Japan), Angkawidjaja Clement,Matsumura Hiroyoshi,Koga Yuichi,Takano Kazufumi,Kanaya Shigenori, Seibutsu Butsuri, The Biophysical Society of Japan General Incorporated Association, Vol. 49, No. 0, 2009