顔写真

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Yamamoto Masahiro
山本　雅裕
Yamamoto Masahiro
山本　雅裕
Institutional repository
Research Institute for Microbial Diseases, Professor
myamamoto biken.osaka-u.ac.jp
Institutional repository

Research History 6

  1. 2018/12 - Present
    Osaka University

  2. 2013/07 - Present
    Osaka University　Research Institute for Microbial Diseases

  3. 2012/01 - 2013/06
    Osaka University　Research Institute for Microbial Diseases

  4. 2010/05 - 2011/12
    Osaka University

  5. 2007/04 - 2010/04
    Osaka University　Graduate School of Medicine

  6. 2006/08 - 2007/03
    Osaka University　Graduate School of Medicine

Education 4

  1. Osaka University

    2003/04 - 2006/03

  2. Osaka University　Graduate School of Medicine

    2001/04 - 2003/03

  3. The University of Tokyo　Faculty of Science　Department of Biological Sciences

    1999/04 - 2001/03

  4. The University of Tokyo　College of Arts and Sciences

    1997/04 - 1999/03

Professional Memberships 2

  1. 日本寄生虫学会

  2. 日本免疫学会

Research Areas 3

  1. Life sciences / Laboratory animal science /

  2. Life sciences / Parasitology /

  3. Life sciences / Veterinary medicine /

Awards 14

  1. 第58回 小島三郎記念文化賞

    黒住医学研究振興財団　2022/10

  2. 野本賞

    日本微生物学連盟　2020/09

  3. 第67回 小泉賞

    日本寄生虫学会　2020/05

  4. 第１５回 日本学術振興会賞

    山本 雅裕　日本学術振興会　2019/02

  5. 第15回（平成30年度）日本学術振興会賞

    2019/02

  6. 第二回 日本医療研究開発機構ＡＭＥＤ理事長賞

    山本 雅裕　内閣府　2018/12

  7. 第2回日本医療研究開発大賞 AMED理事長賞

    2018/12

  8. Highly Cited Researchers 2017

    Masahiro Yamamoto　Clarivate Analytics　2017/12

  9. Highly Cited Researchers 2016

    山本 雅裕　Clarivate Analytics(旧トムソン・ロイター IP&Science)　2016/11

  10. 科学技術分野の文部科学大臣 表彰 若手科学者

    山本雅裕　文部科学省　2011/04

  11. 科学技術分野の文部科学大臣 表彰若手科学者

    文部科学省　2011/04

  12. 第2回 日本免疫学会研究奨励賞

    日本免疫学会　2007/12

  13. 日本免疫学会研究奨励賞

    山本雅裕　日本免疫学会　2007/11

  14. 山村賞

    山本雅裕　大阪大学大学院医学系研究科　2006/03

Papers 216

  1. Toxoplasma GRA15 expression on dendritic cells inhibits B cell differentiation and antibody production.

    Yuki Nakayama, Fumiaki Ihara, Daisuke Okuzaki, Yoshifumi Nishikawa, Miwa Sasai, Masahiro Yamamoto

    Parasitology international　Vol. 105　p. 102995-102995　2025/04　Research paper (scientific journal)

  2. IFN-γ-induced Th1-Treg polarization in inflamed brains limits exacerbation of experimental autoimmune encephalomyelitis.

    Masaaki Okamoto, Ayumi Kuratani, Daisuke Okuzaki, Naganori Kamiyama, Takashi Kobayashi, Miwa Sasai, Masahiro Yamamoto

    Proceedings of the National Academy of Sciences of the United States of America　Vol. 121　No. 48　2024/11/26　Research paper (scientific journal)

  3. Platelet factor 4-induced TH1-Treg polarization suppresses antitumor immunity.

    Ayumi Kuratani, Masaaki Okamoto, Kazuki Kishida, Daisuke Okuzaki, Miwa Sasai, Shimon Sakaguchi, Hisashi Arase, Masahiro Yamamoto

    Science (New York, N.Y.)　Vol. 386　No. 6724　2024/11/22　Research paper (scientific journal)

  4. CRISPR screens identify genes essential for in vivo virulence among proteins of hyperLOPIT-unassigned subcellular localization in Toxoplasma.

    Yuta Tachibana, Miwa Sasai, Masahiro Yamamoto

    mBio　Vol. 15　No. 9　2024/09/11　Research paper (scientific journal)

  5. Tff1-expressing Tregs in lung prevent exacerbation of Bleomycin-induced pulmonary fibrosis.

    Masaaki Okamoto, Ayumi Kuratani, Daisuke Okuzaki, Naganori Kamiyama, Takashi Kobayashi, Miwa Sasai, Masahiro Yamamoto

    Frontiers in immunology　Vol. 15　p. 1440918-1440918　2024/09　Research paper (scientific journal)

  6. Far-East Asian Toxoplasma isolates share ancestry with North and South/Central American recombinant lineages.

    Fumiaki Ihara, Hisako Kyan, Yasuhiro Takashima, Fumiko Ono, Kei Hayashi, Tomohide Matsuo, Makoto Igarashi, Yoshifumi Nishikawa, Kenji Hikosaka, Hirokazu Sakamoto, Shota Nakamura, Daisuke Motooka, Kiyoshi Yamauchi, Madoka Ichikawa-Seki, Shinya Fukumoto, Motoki Sasaki, Hiromi Ikadai, Kodai Kusakisako, Yuma Ohari, Ayako Yoshida, Miwa Sasai, Michael E Grigg, Masahiro Yamamoto

    Nature communications　Vol. 15　No. 1　p. 4278-4278　2024/05/22　Research paper (scientific journal)

  7. A genetic method specifically delineates Th1-type Treg cells and their roles in tumor immunity.

    Masaaki Okamoto, Miwa Sasai, Ayumi Kuratani, Daisuke Okuzaki, Masaya Arai, James B Wing, Shimon Sakaguchi, Masahiro Yamamoto

    Cell reports　Vol. 42　No. 7　p. 112813-112813　2023/07/25　Research paper (scientific journal)

  8. Host genetics highlights IFN-γ-dependent Toxoplasma genes encoding secreted and non-secreted virulence factors in in vivo CRISPR screens.

    Yuta Tachibana, Emi Hashizaki, Miwa Sasai, Masahiro Yamamoto

    Cell reports　Vol. 42　No. 6　p. 112592-112592　2023/06/01　Research paper (scientific journal)

  9. Toxoplasma IWS1 Determines Fitness in Interferon-γ-Activated Host Cells and Mice by Indirectly Regulating ROP18 mRNA Expression.

    Emi Hashizaki, Miwa Sasai, Daisuke Okuzaki, Tsubasa Nishi, Takashi Kobayashi, Shiroh Iwanaga, Masahiro Yamamoto

    mBio　Vol. 14　No. 1　2023/02/28　Research paper (scientific journal)

  10. Plasmodium UIS3 avoids host cell-autonomous exclusion that requires GABARAPs but not LC3 and autophagy

    Ariel Pradipta, Hironori Bando, Ji Su Ma, Shun Tanaka, Miwa Sasai, Masahiro Yamamoto

    Parasitology International　Vol. 83　2021/08　Research paper (scientific journal)

  11. Uncovering a novel role of PLCβ4 in selectively mediating TCR signaling in CD8+ but not CD4+ T cells.

    Miwa Sasai, Ji Su Ma, Masaaki Okamoto, Kohei Nishino, Hikaru Nagaoka, Eizo Takashima, Ariel Pradipta, Youngae Lee, Hidetaka Kosako, Pann-Ghill Suh, Masahiro Yamamoto

    The Journal of experimental medicine　Vol. 218　No. 7　2021/07/05　Research paper (scientific journal)

  12. Cell-autonomous Toxoplasma killing program requires Irgm2 but not its microbe vacuolar localization.

    Ariel Pradipta, Miwa Sasai, Kou Motani, Ji Su Ma, Youngae Lee, Hidetaka Kosako, Masahiro Yamamoto

    Life science alliance　Vol. 4　No. 7　2021/07　Research paper (scientific journal)

  13. Role of Gate-16 and Gabarap in Prevention of Caspase-11-Dependent Excess Inflammation and Lethal Endotoxic Shock

    Naoya Sakaguchi, Miwa Sasai, Hironori Bando, Youngae Lee, Ariel Pradipta, Ji Su Ma, Masahiro Yamamoto

    Frontiers in Immunology　Vol. 11　p. 561948-561948　2020/09/15　Research paper (scientific journal)

  14. T cell-derived interferon-γ is required for host defense to Toxoplasma gondii.

    Saishi Nishiyama, Ariel Pradipta, Ji Su Ma, Miwa Sasai, Masahiro Yamamoto

    Parasitology international　Vol. 75　p. 102049-102049　2020/04　Research paper (scientific journal)

  15. Decision by injection without infection.

    Miwa Sasai, Masahiro Yamamoto

    The Journal of experimental medicine　Vol. 217　No. 3　2020/03/02　Research paper (scientific journal)

  16. Initial phospholipid-dependent Irgb6 targeting to Toxoplasma gondii vacuoles mediates host defense.

    Youngae Lee, Hiroshi Yamada, Ariel Pradipta, Ji Su Ma, Masaaki Okamoto, Hikaru Nagaoka, Eizo Takashima, Daron M Standley, Miwa Sasai, Kohji Takei, Masahiro Yamamoto

    Life science alliance　Vol. 3　No. 1　2020/01　Research paper (scientific journal)

  17. CXCR4 regulates Plasmodium development in mouse and human hepatocytes

    Hironori Bando, Ariel Pradipta, Shiroh Iwanaga, Toru Okamoto, Daisuke Okuzaki, Shun Tanaka, Joel Vega-Rodríguez, Youngae Lee, Ji Su Ma, Naoya Sakaguchi, Akira Soga, Shinya Fukumoto, Miwa Sasai, Yoshiharu Matsuura, Masao Yuda, Marcelo Jacobs-Lorena, Masahiro Yamamoto

    Journal of Experimental Medicine　Vol. 216　No. 8　p. 1733-1748　2019/08/01　Research paper (scientific journal)

  18. Toxoplasma Effector GRA15-Dependent Suppression of IFN-γ-Induced Antiparasitic Response in Human Neurons.

    Hironori Bando, Youngae Lee, Naoya Sakaguchi, Ariel Pradipta, Ryoma Sakamoto, Shun Tanaka, Ji Su Ma, Miwa Sasai, Masahiro Yamamoto

    Frontiers in cellular and infection microbiology　Vol. 9　No. MAY　p. 140-140　2019　Research paper (scientific journal)

  19. Inducible Nitric Oxide Synthase Is a Key Host Factor for Toxoplasma GRA15-Dependent Disruption of the Gamma Interferon-Induced Antiparasitic Human Response.

    Hironori Bando, Youngae Lee, Naoya Sakaguchi, Ariel Pradipta, Ji Su Ma, Shun Tanaka, Yihong Cai, Jianfa Liu, Jilong Shen, Yoshifumi Nishikawa, Miwa Sasai, Masahiro Yamamoto

    mBio　Vol. 9　No. 5　2018/10/09　Research paper (scientific journal)

  20. Toxoplasma Effector TgIST Targets Host IDO1 to Antagonize the IFN-γ-Induced Anti-parasitic Response in Human Cells.

    Hironori Bando, Naoya Sakaguchi, Youngae Lee, Ariel Pradipta, Ji Su Ma, Shun Tanaka, De-Hua Lai, Jianfa Liu, Zhao-Rong Lun, Yoshifumi Nishikawa, Miwa Sasai, Masahiro Yamamoto

    Frontiers in immunology　Vol. 9　No. SEP　p. 2073-2073　2018　Research paper (scientific journal)

  21. Essential role for GABARAP autophagy proteins in interferon-inducible GTPase-mediated host defense.

    Miwa Sasai, Naoya Sakaguchi, Ji Su Ma, Shuhei Nakamura, Tsuyoshi Kawabata, Hironori Bando, Youngae Lee, Tatsuya Saitoh, Shizuo Akira, Akiko Iwasaki, Daron M Standley, Tamotsu Yoshimori, Masahiro Yamamoto

    Nature immunology　Vol. 18　No. 8　p. 899-910　2017/08　Research paper (scientific journal)

  22. p62 Plays a Specific Role in Interferon-γ-Induced Presentation of a Toxoplasma Vacuolar Antigen.

    Youngae Lee, Miwa Sasai, Ji Su Ma, Naoya Sakaguchi, Jun Ohshima, Hironori Bando, Tatsuya Saitoh, Shizuo Akira, Masahiro Yamamoto

    Cell reports　Vol. 13　No. 2　p. 223-33　2015/10/13　Research paper (scientific journal)

  23. RabGDIα is a negative regulator of interferon-γ-inducible GTPase-dependent cell-autonomous immunity to Toxoplasma gondii.

    Jun Ohshima, Miwa Sasai, Jianfa Liu, Kazuo Yamashita, Ji Su Ma, Youngae Lee, Hironori Bando, Jonathan C Howard, Shigeyuki Ebisu, Mikako Hayashi, Kiyoshi Takeda, Daron M Standley, Eva-Maria Frickel, Masahiro Yamamoto

    Proceedings of the National Academy of Sciences of the United States of America　Vol. 112　No. 33　p. E4581-90-E4590　2015/08/18　Research paper (scientific journal)

  24. Selective and strain-specific NFAT4 activation by the Toxoplasma gondii polymorphic dense granule protein GRA6.

    Ji Su Ma, Miwa Sasai, Jun Ohshima, Youngae Lee, Hironori Bando, Kiyoshi Takeda, Masahiro Yamamoto

    The Journal of experimental medicine　Vol. 211　No. 10　p. 2013-32　2014/09/22　Research paper (scientific journal)

  25. Role of mouse and human autophagy proteins in IFN-γ-induced cell-autonomous responses against Toxoplasma gondii.

    Jun Ohshima, Youngae Lee, Miwa Sasai, Tatsuya Saitoh, Ji Su Ma, Naganori Kamiyama, Yoshiharu Matsuura, Suh Pann-Ghill, Mikako Hayashi, Shigeyuki Ebisu, Kiyoshi Takeda, Shizuo Akira, Masahiro Yamamoto

    Journal of immunology (Baltimore, Md. : 1950)　Vol. 192　No. 7　p. 3328-35　2014/04/01　Research paper (scientific journal)

  26. A cluster of interferon-γ-inducible p65 GTPases plays a critical role in host defense against Toxoplasma gondii.

    Masahiro Yamamoto, Megumi Okuyama, Ji Su Ma, Taishi Kimura, Naganori Kamiyama, Hiroyuki Saiga, Jun Ohshima, Miwa Sasai, Hisako Kayama, Toru Okamoto, David C S Huang, Dominique Soldati-Favre, Kyoji Horie, Junji Takeda, Kiyoshi Takeda

    Immunity　Vol. 37　No. 2　p. 302-13　2012/08/24　Research paper (scientific journal)

  27. ATF6beta is a host cellular target of the Toxoplasma gondii virulence factor ROP18.

    Masahiro Yamamoto, Ji Su Ma, Christina Mueller, Naganori Kamiyama, Hiroyuki Saiga, Emi Kubo, Taishi Kimura, Toru Okamoto, Megumi Okuyama, Hisako Kayama, Kisaburo Nagamune, Seiji Takashima, Yoshiharu Matsuura, Dominique Soldati-Favre, Kiyoshi Takeda

    The Journal of experimental medicine　Vol. 208　No. 7　p. 1533-46　2011/07/04　Research paper (scientific journal)

  28. E2 polyubiquitin-conjugating enzyme Ubc13 in keratinocytes is essential for epidermal integrity

    Koji Sayama, Masahiro Yamamoto, Yuji Shirakata, Yasushi Hanakawa, Satoshi Hirakawa, Xiuju Dai, Mikiko Tohyama, Sho Tokumaru, Myoung Sook Shin, Hiroaki Sakurai, Shizuo Akira, Koji Hashimoto

    Journal of Biological Chemistry　Vol. 285　No. 39　p. 30042-30049　2010/09/24　Research paper (scientific journal)

  29. A single polymorphic amino acid on Toxoplasma gondii kinase ROP16 determines the direct and strain-specific activation of Stat3.

    Masahiro Yamamoto, Daron M Standley, Seiji Takashima, Hiroyuki Saiga, Megumi Okuyama, Hisako Kayama, Emi Kubo, Hiroshi Ito, Mutsumi Takaura, Tadashi Matsuda, Dominique Soldati-Favre, Kiyoshi Takeda

    The Journal of experimental medicine　Vol. 206　No. 12　p. 2747-60　2009/11/23　Research paper (scientific journal)

  30. Enhanced TLR-mediated NF-IL6-dependent gene expression by Trib1 deficiency

    Masahiro Yamamoto, Satoshi Uematsu, Toru Okamoto, Yoshiharu Matsuura, Shintaro Sato, Himanshu Kumar, Takashi Satoh, Tatsuya Saitoh, Kiyoshi Takeda, Ken J. Ishii, Osamu Takeuchi, Taro Kawai, Shizuo Akira

    Journal of Experimental Medicine　Vol. 204　No. 9　p. 2233-2239　2007/09/03　Research paper (scientific journal)

  31. Cutting edge: Pivotal function of Ubc13 in thymocyte TCR signaling

    Masahiro Yamamoto, Shintaro Sato, Tatsuya Saitoh, Hiroaki Sakurai, Satoshi Uematsu, Taro Kawai, Ken J. Ishii, Osamu Takeuchi, Shizuo Akira

    Journal of Immunology　Vol. 177　No. 11　p. 7520-7524　2006/12/01　Research paper (scientific journal)

  32. Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling

    Masahiro Yamamoto, Toru Okamoto, Kiyoshi Takeda, Shintaro Sato, Hideki Sanjo, Satoshi Uematsu, Tatsuya Saitoh, Naoki Yamamoto, Hiroaki Sakurai, Ken J. Ishii, Shoji Yamaoka, Taro Kawai, Yoshiharu Matsuura, Osamu Takeuchi, Shizuo Akira

    Nature Immunology　Vol. 7　No. 9　p. 962-970　2006/09　Research paper (scientific journal)

  33. Regulation of Toll/IL-1-receptor-mediated gene expression by the inducible nuclear protein IκBζ

    Masahiro Yamamoto, Soh Yamazaki, Satoshi Uematsu, Shintaro Sato, Hiroaki Hemmmi, Katsuaki Hoshino, Tsuneyasu Kaisho, Hirotaka Kuwata, Osamu Takeuchi, Koichiro Takeshige, Tatsuya Saitoh, Shoji Yamaoka, Naoki Yamamoto, Shunsuke Yamamoto, Tatsushi Muta, Kiyoshi Takeda, Shizuo Akira

    Nature　Vol. 430　No. 6996　p. 218-222　2004/07/08　Research paper (scientific journal)

  34. TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway

    Masahiro Yamamoto, Shintaro Sato, Hiroaki Hemmi, Satoshi Uematsu, Katsuaki Hoshino, Tsuneyasu Kaisho, Osamu Takeuchi, Kiyoshi Takeda, Shizuo Akira

    Nature Immunology　Vol. 4　No. 11　p. 1144-1150　2003/11　Research paper (scientific journal)

  35. Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway

    Masahiro Yamamoto, Shintaro Sato, Hiroaki Hemmi, Katsuaki Hoshino, Tsuneyasu Kaisho, Hideki Sanjo, Osamu Takeuchi, Masanaka Sugiyama, Masaru Okabe, Kiyoshi Takeda, Shizuo Akira

    Science　Vol. 301　No. 5633　p. 640-643　2003/08/01　Research paper (scientific journal)

  36. Cutting edge: A novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-β promoter in the Toll-like receptor signaling

    Masahiro Yamamoto, Shintaro Sato, Kiyotoshi Mori, Katsuaki Hoshino, Osamu Takeuchi, Kiyoshi Takeda, Shizuo Akira

    Journal of Immunology　Vol. 169　No. 12　p. 6668-6672　2002/12/15　Research paper (scientific journal)

  37. Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4

    Masahiro Yamamoto, Shintaro Sato, Hiroaki Hemmi, Hideki Sanjo, Satoshi Uematsu, Tsuneyasu Kaisho, Katsuaki Hoshino, Osamu Takeuchi, Masaya Kobayashi, Takashi Fujita, Kiyoshi Takeda, Shizuo Akira

    Nature　Vol. 420　No. 6913　p. 324-329　2002/11/21　Research paper (scientific journal)

  38. Recent advances in identifying and characterizing secretory proteins of Toxoplasma gondii by CRISPR-based screening.

    Yuta Tachibana, Masahiro Yamamoto

    Parasitology international　Vol. 105　p. 102997-102997　2025/04

  39. Targeted labeling and depletion of alveolar macrophages using VeDTR mouse technology.

    Yuki Nakayama, Miwa Sasai, Ayumi Kuratani, Masaaki Okamoto, Daisuke Okuzaki, Kentaro Yamamoto, Chikako Ono, Masaya Yamaguchi, Shigetada Kawabata, Noriko Shinjyo, Yasutaka Okabe, Yoshiharu Matsuura, Manabu Ato, Masahiro Yamamoto

    iScience　Vol. 28　No. 3　p. 111975-111975　2025/03/21　Research paper (scientific journal)

    Publisher: Elsevier BV

  40. Discrepancies in the Diagnosis of Congenital Toxoplasma gondii Infection Between B1 Gene Semi-Nested Polymerase Chain Reaction and Serological Analyses.

    Akiko Uchida, Kenji Tanimura, Keisuke Shirai, Mariko Ashina, Kazumichi Fujioka, Ichiro Morioka, Miwa Sasai, Masahiro Yamamoto, Hideto Yamada

    Microorganisms　Vol. 13　No. 3　2025/03/05　Research paper (scientific journal)

  41. Lipid mediator palmitoylethanolamide (PEA) inhibits pathogenic T cell differentiation in vitro and in vivo.

    Yasuhiro Soga, Naganori Kamiyama, Takashi Ozaki, Thanyakorn Chalalai, Nozomi Sachi, Sotaro Ozaka, Yomei Kagoshima, Supanuch Ekronarongchai, Masahiro Yamamoto, Takashi Kobayashi

    Biochemical and biophysical research communications　Vol. 743　p. 151085-151085　2025/01　Research paper (scientific journal)

  42. Caspase-11 mediated inflammasome activation in macrophages by systemic infection of A. actinomycetemcomitans exacerbates arthritis.

    Tokuju Okano, Hiroshi Ashida, Noriko Komatsu, Masayuki Tsukasaki, Tamako Iida, Marie Iwasawa, Yuto Takahashi, Yasuo Takeuchi, Takanori Iwata, Miwa Sasai, Masahiro Yamamoto, Hiroshi Takayanagi, Toshihiko Suzuki

    International journal of oral science　Vol. 16　No. 1　p. 54-54　2024/08/15　Research paper (scientific journal)

  43. IFNγ Production by Functionally Reprogrammed Tregs Promotes Antitumor Efficacy of OX40/CD137 Bispecific Agonist Therapy.

    Charlotte J Imianowski, Paula Kuo, Sarah K Whiteside, Teresa von Linde, Alexander J Wesolowski, Alberto G Conti, Alexander C Evans, Tarrion Baird, Benjamin I Morris, Nicole E Fletcher, Jie Yang, Edmund Poon, Matthew A Lakins, Masahiro Yamamoto, Neil Brewis, Michelle Morrow, Rahul Roychoudhuri

    Cancer research communications　Vol. 4　No. 8　p. 2045-2057　2024/08/01　Research paper (scientific journal)

  44. CCR2-dependent placental migration of inflammatory monocytes suppresses abnormal pregnancies caused by Toxoplasma gondii infection.

    Naganori Kamiyama, Mai Ueno, Yuma Sasaki, Thanyakorn Chalalai, Nozomi Sachi, Sotaro Ozaka, Yasuhiro Soga, Yomei Kagoshima, Supanuch Ekronarongchai, Masaaki Okamoto, Masahiro Yamamoto, Takashi Kobayashi

    International immunology　Vol. 37　No. 1　p. 39-52　2024/07/25　Research paper (scientific journal)

  45. Phospholipase C-β3 is dispensable for vascular constriction but indispensable for vascular hyperplasia.

    Seo Yeon Jin, Jung Min Ha, Hye Jin Kum, Ji Soo Ma, Hong Koo Ha, Sang Heon Song, Yong Ryoul Yang, Ho Lee, Yoon Soo Bae, Masahiro Yamamoto, Pann-Ghill Suh, Sun Sik Bae

    Experimental & molecular medicine　Vol. 56　No. 7　p. 1620-1630　2024/07/01　Research paper (scientific journal)

  46. Regulation of memory CD4+ T cell generation by intrinsic and extrinsic IL-27 signaling during malaria infection.

    Sanjaadorj Tsogtsaikhan, Shin-Ichi Inoue, Ganchimeg Bayarsaikhan, Maria Lourdes Macalinao, Daisuke Kimura, Mana Miyakoda, Masahiro Yamamoto, Hiromitsu Hara, Hiroki Yoshida, Katsuyuki Yui

    International immunology　Vol. 36　No. 12　p. 629-640　2024/06/19　Research paper (scientific journal)

  47. Individual Atg8 paralogs and a bacterial metabolite sequentially promote hierarchical CASM-xenophagy induction and transition.

    Chisato Sakuma, Sayaka Shizukuishi, Michinaga Ogawa, Yuko Honjo, Haruko Takeyama, Jun-Lin Guan, Jeffery Weiser, Miwa Sasai, Masahiro Yamamoto, Makoto Ohnishi, Yukihiro Akeda

    Cell reports　Vol. 43　No. 5　p. 114131-114131　2024/05/28　Research paper (scientific journal)

  48. The role of IFN-γ-mediated host immune responses in monitoring and the elimination of Toxoplasma gondii infection.

    Fumiaki Ihara, Masahiro Yamamoto

    International immunology　Vol. 36　No. 5　p. 199-210　2024/04/03　Research paper (scientific journal)

  49. TCR Signals Controlling Adaptive Immunity against Toxoplasma and Cancer.

    Masaaki Okamoto, Masahiro Yamamoto

    Advances in experimental medicine and biology　Vol. 1444　p. 177-193　2024/03/01　Research paper (scientific journal)

  50. 5,6-dimethylxanthenone-4-acetic acid (DMXAA), a partial STING agonist, competes for human STING activation.

    Burcu Temizoz, Takayuki Shibahara, Kou Hioki, Tomoya Hayashi, Kouji Kobiyama, Michelle Sue Jann Lee, Naz Surucu, Erdal Sag, Atsushi Kumanogoh, Masahiro Yamamoto, Mayda Gursel, Seza Ozen, Etsushi Kuroda, Cevayir Coban, Ken J Ishii

    Frontiers in immunology　Vol. 15　p. 1353336-1353336　2024/03/01　Research paper (scientific journal)

  51. Structural basis of Irgb6 inactivation by Toxoplasma gondii through the phosphorylation of switch I.

    Hiromichi Okuma, Yumiko Saijo-Hamano, Hiroshi Yamada, Aalaa Alrahman Sherif, Emi Hashizaki, Naoki Sakai, Takaaki Kato, Tsuyoshi Imasaki, Satoshi Kikkawa, Eriko Nitta, Miwa Sasai, Tadashi Abe, Fuminori Sugihara, Yoshimasa Maniwa, Hidetaka Kosako, Kohji Takei, Daron M Standley, Masahiro Yamamoto, Ryo Nitta

    Genes to cells : devoted to molecular & cellular mechanisms　Vol. 29　No. 1　p. 17-38　2024/01/01　Research paper (scientific journal)

  52. Amino acid catabolite markers for early prognostication of pneumonia in patients with COVID-19.

    Rae Maeda, Natsumi Seki, Yoshifumi Uwamino, Masatoshi Wakui, Yu Nakagama, Yasutoshi Kido, Miwa Sasai, Shu Taira, Naoya Toriu, Masahiro Yamamoto, Yoshiharu Matsuura, Jun Uchiyama, Genki Yamaguchi, Makoto Hirakawa, Yun-Gi Kim, Masayo Mishima, Motoko Yanagita, Makoto Suematsu, Yuki Sugiura

    Nature communications　Vol. 14　No. 1　p. 8469-8469　2023/12/20　Research paper (scientific journal)

  53. PIM1 controls GBP1 activity to limit self-damage and to guard against pathogen infection.

    Daniel Fisch, Moritz M Pfleiderer, Eleni Anastasakou, Gillian M Mackie, Fabian Wendt, Xiangyang Liu, Barbara Clough, Samuel Lara-Reyna, Vesela Encheva, Ambrosius P Snijders, Hironori Bando, Masahiro Yamamoto, Andrew D Beggs, Jason Mercer, Avinash R Shenoy, Bernd Wollscheid, Kendle M Maslowski, Wojtek P Galej, Eva-Maria Frickel

    Science (New York, N.Y.)　Vol. 382　No. 6666　2023/10/06　Research paper (scientific journal)

  54. Retinal ferroptosis as a critical mechanism for the induction of retinochoroiditis during ocular toxoplasmosis.

    Kazuhisa Yamada, Akira Tazaki, Nanako Ushio-Watanabe, Yoshihiko Usui, Atsunobu Takeda, Masaaki Matsunaga, Ayana Suzumura, Hideyuki Shimizu, Hao Zheng, Nanang R Ariefta, Masahiro Yamamoto, Hideaki Hara, Hiroshi Goto, Koh-Hei Sonoda, Koji M Nishiguchi, Masashi Kato, Yoshifumi Nishikawa, Shinya Toyokuni, Hiroki Kaneko

    Redox biology　Vol. 67　p. 102890-102890　2023/09/17　Research paper (scientific journal)

  55. Fusobacterium nucleatum infection activates the noncanonical inflammasome and exacerbates inflammatory response in DSS-induced colitis.

    Kotchakorn Boonyaleka, Tokuju Okano, Tamako Iida, Anongwee Leewananthawet, Miwa Sasai, Masahiro Yamamoto, Hiroshi Ashida, Toshihiko Suzuki

    European journal of immunology　Vol. 53　No. 11　2023/07/20　Research paper (scientific journal)

  56. Immunity against Moraxella catarrhalis requires guanylate-binding proteins and caspase-11-NLRP3 inflammasomes.

    Daniel Enosi Tuipulotu, Shouya Feng, Abhimanu Pandey, Anyang Zhao, Chinh Ngo, Anukriti Mathur, Jiwon Lee, Cheng Shen, Daniel Fox, Yansong Xue, Callum Kay, Max Kirkby, Jordan Lo Pilato, Nadeem O Kaakoush, Daryl Webb, Melanie Rug, Avril Ab Robertson, Melkamu B Tessema, Stanley Pang, Daniel Degrandi, Klaus Pfeffer, Daria Augustyniak, Antje Blumenthal, Lisa A Miosge, Anne Brüstle, Masahiro Yamamoto, Patrick C Reading, Gaetan Burgio, Si Ming Man

    The EMBO journal　Vol. 42　No. 6　2023/03/15　Research paper (scientific journal)

  57. TFEB-mediated lysosomal exocytosis alleviates high-fat diet-induced lipotoxicity in the kidney.

    Jun Nakamura, Takeshi Yamamoto, Yoshitsugu Takabatake, Tomoko Namba-Hamano, Satoshi Minami, Atsushi Takahashi, Jun Matsuda, Shinsuke Sakai, Hiroaki Yonishi, Shihomi Maeda, Sho Matsui, Isao Matsui, Takayuki Hamano, Masatomo Takahashi, Maiko Goto, Yoshihiro Izumi, Takeshi Bamba, Miwa Sasai, Masahiro Yamamoto, Taiji Matsusaka, Fumio Niimura, Motoko Yanagita, Shuhei Nakamura, Tamotsu Yoshimori, Andrea Ballabio, Yoshitaka Isaka

    JCI insight　Vol. 8　No. 4　2023/02/22　Research paper (scientific journal)

  58. Macrophages inhibit Coxiella burnetii by the ACOD1-itaconate pathway for containment of Q fever.

    Lisa Kohl, Md Nur A Alam Siddique, Barbara Bodendorfer, Raffaela Berger, Annica Preikschat, Christoph Daniel, Martha Ölke, Elisabeth Liebler-Tenorio, Jan Schulze-Luehrmann, Michael Mauermeir, Kai-Ting Yang, Inaya Hayek, Manuela Szperlinski, Jennifer Andrack, Ulrike Schleicher, Aline Bozec, Gerhard Krönke, Peter J Murray, Stefan Wirtz, Masahiro Yamamoto, Valentin Schatz, Jonathan Jantsch, Peter Oefner, Daniel Degrandi, Klaus Pfeffer, Katja Mertens-Scholz, Simon Rauber, Christian Bogdan, Katja Dettmer, Anja Lührmann, Roland Lang

    EMBO molecular medicine　Vol. 15　No. 2　2023/02/08　Research paper (scientific journal)

  59. ROP39 is an Irgb10-specific parasite effector that modulates acute Toxoplasma gondii virulence.

    Shishir Singh, Mateo Murillo-León, Niklas Sebastian Endres, Ailan Farid Arenas Soto, Jorge Enrique Gómez-Marín, Florence Melbert, Thirumala-Devi Kanneganti, Masahiro Yamamoto, Claudia Campos, Jonathan Charles Howard, Gregory Alan Taylor, Tobias Steinfeldt

    PLoS pathogens　Vol. 19　No. 1　2023/01/01　Research paper (scientific journal)

  60. Modified DNA vaccine confers improved humoral immune response and effective virus protection against SARS-CoV-2 delta variant.

    Hiroki Hayashi, Jiao Sun, Yuka Yanagida, Takako Otera, Miwa Sasai, Chin Yang Chang, Jiayu A Tai, Tomoyuki Nishikawa, Kunihiko Yamashita, Naoki Sakaguchi, Shota Yoshida, Satoshi Baba, Munehisa Shimamura, Sachiko Okamoto, Yasunori Amaishi, Hideto Chono, Junichi Mineno, Hiromi Rakugi, Ryuichi Morishita, Masahiro Yamamoto, Hironori Nakagami

    Scientific reports　Vol. 12　No. 1　p. 20923-20923　2022/12/03　Research paper (scientific journal)

  61. Immune response induced in rodents by anti-CoVid19 plasmid DNA vaccine via pyro-drive jet injector inoculation.

    Tomoyuki Nishikawa, Chin Yang Chang, Jiayu A Tai, Hiroki Hayashi, Jiao Sun, Shiho Torii, Chikako Ono, Yoshiharu Matsuura, Ryoko Ide, Junichi Mineno, Miwa Sasai, Masahiro Yamamoto, Hironori Nakagami, Kunihiko Yamashita

    Immunological medicine　Vol. 45　No. 4　p. 251-264　2022/12　Research paper (scientific journal)

  62. Author Correction: LC3 lipidation is essential for TFEB activation during the lysosomal damage response to kidney injury.

    Shuhei Nakamura, Saki Shigeyama, Satoshi Minami, Takayuki Shima, Shiori Akayama, Tomoki Matsuda, Alessandra Esposito, Gennaro Napolitano, Akiko Kuma, Tomoko Namba-Hamano, Jun Nakamura, Kenichi Yamamoto, Miwa Sasai, Ayaka Tokumura, Mika Miyamoto, Yukako Oe, Toshiharu Fujita, Seigo Terawaki, Atsushi Takahashi, Maho Hamasaki, Masahiro Yamamoto, Yukinori Okada, Masaaki Komatsu, Takeharu Nagai, Yoshitsugu Takabatake, Haoxing Xu, Yoshitaka Isaka, Andrea Ballabio, Tamotsu Yoshimori

    Nature cell biology　Vol. 24　No. 11　p. 1677-1679　2022/11/01　Research paper (scientific journal)

  63. Recruitment of Irgb6 to the membrane is a direct trigger for membrane deformation.

    Hiroshi Yamada, Tadashi Abe, Hikaru Nagaoka, Eizo Takashima, Ryo Nitta, Masahiro Yamamoto, Kohji Takei

    Frontiers in cellular and infection microbiology　Vol. 12　p. 992198-992198　2022/09/01　Research paper (scientific journal)

  64. Anti-Toxoplasma host defense systems and the parasitic counterdefense mechanisms.

    Miwa Sasai, Masahiro Yamamoto

    Parasitology international　Vol. 89　p. 102593-102593　2022/08/01　Research paper (scientific journal)

  65. Pathogen-selective killing by guanylate-binding proteins as a molecular mechanism leading to inflammasome signaling.

    Shouya Feng, Daniel Enosi Tuipulotu, Abhimanu Pandey, Weidong Jing, Cheng Shen, Chinh Ngo, Melkamu B Tessema, Fei-Ju Li, Daniel Fox, Anukriti Mathur, Anyang Zhao, Runli Wang, Klaus Pfeffer, Daniel Degrandi, Masahiro Yamamoto, Patrick C Reading, Gaetan Burgio, Si Ming Man

    Nature communications　Vol. 13　No. 1　p. 4395-4395　2022/07/29　Research paper (scientific journal)

  66. A prospective cohort study of newborns born to mothers with serum Toxoplasma gondii immunoglobulin M positivity during pregnancy.

    Midori Hijikata, Ichiro Morioka, Aya Okahashi, Nobuhiko Nagano, Kaori Kawakami, Atsushi Komatsu, Kei Kawana, Shohei Ohyama, Kazumichi Fujioka, Kenji Tanimura, Masashi Deguchi, Miwa Sasai, Masahiro Yamamoto, Hideto Yamada

    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy　Vol. 28　No. 4　p. 486-491　2022/04/01　Research paper (scientific journal)

  67. SARS-CoV-2 infection triggers paracrine senescence and leads to a sustained senescence-associated inflammatory response

    Shunya Tsuji, Shohei Minami, Rina Hashimoto, Yusuke Konishi, Tatsuya Suzuki, Tamae Kondo, Miwa Sasai, Shiho Torii, Chikako Ono, Shintaro Shichinohe, Shintaro Sato, Masahiro Wakita, Shintaro Okumura, Sosuke Nakano, Tatsuyuki Matsudaira, Tomonori Matsumoto, Shimpei Kawamoto, Masahiro Yamamoto, Tokiko Watanabe, Yoshiharu Matsuura, Kazuo Takayama, Takeshi Kobayashi, Toru Okamoto, Eiji Hara

    Nature Aging　Vol. 2　No. 2　p. 115-124　2022/02　Research paper (scientific journal)

    Publisher: Springer Science and Business Media LLC

  68. The IFN-inducible GTPase IRGB10 regulates viral replication and inflammasome activation during influenza A virus infection in mice.

    Shelbi Christgen, David E Place, Min Zheng, Benoit Briard, Masahiro Yamamoto, Thirumala-Devi Kanneganti

    European journal of immunology　Vol. 52　No. 2　p. 285-296　2022/02/01　Research paper (scientific journal)

  69. Enterocyte-innate lymphoid cell crosstalk drives early IFN-γ-mediated control of Cryptosporidium.

    Jodi A Gullicksrud, Adam Sateriale, Julie B Engiles, Alexis R Gibson, Sebastian Shaw, Zachary A Hutchins, Lindsay Martin, David A Christian, Gregory A Taylor, Masahiro Yamamoto, Daniel P Beiting, Boris Striepen, Christopher A Hunter

    Mucosal immunology　Vol. 15　No. 2　p. 362-372　2022/02/01　Research paper (scientific journal)

  70. Structural basis of membrane recognition of Toxoplasma gondii vacuole by Irgb6.

    Yumiko Saijo-Hamano, Aalaa Alrahman Sherif, Ariel Pradipta, Miwa Sasai, Naoki Sakai, Yoshiaki Sakihama, Masahiro Yamamoto, Daron M Standley, Ryo Nitta

    Life science alliance　Vol. 5　No. 1　2022/01/01　Research paper (scientific journal)

  71. Macrophages Demonstrate Guanylate-Binding Protein-Dependent and Bacterial Strain-Dependent Responses to Francisella tularensis.

    Nasibeh Mohammadi, Helena Lindgren, Masahiro Yamamoto, Amandine Martin, Thomas Henry, Anders Sjöstedt

    Frontiers in cellular and infection microbiology　Vol. 11　p. 784101-784101　2021/12/24　Research paper (scientific journal)

  72. High resistance to Toxoplasma gondii infection in inducible nitric oxide synthase knockout rats.

    Zhen-Jie Wang, Shao-Meng Yu, Jiang-Mei Gao, Peng Zhang, Geoff Hide, Masahiro Yamamoto, De-Hua Lai, Zhao-Rong Lun

    iScience　Vol. 24　No. 11　p. 103280-103280　2021/11/19　Research paper (scientific journal)

  73. Chlamydia evasion of neutrophil host defense results in NLRP3 dependent myeloid-mediated sterile inflammation through the purinergic P2X7 receptor.

    Chunfu Yang, Lei Lei, John W Marshall Collins, Michael Briones, Li Ma, Gail L Sturdevant, Hua Su, Anuj K Kashyap, David Dorward, Kevin W Bock, Ian N Moore, Christine Bonner, Chih-Yu Chen, Craig A Martens, Stacy Ricklefs, Masahiro Yamamoto, Kiyoshi Takeda, Yoichiro Iwakura, Grant McClarty, Harlan D Caldwell

    Nature communications　Vol. 12　No. 1　p. 5454-5454　2021/09/15　Research paper (scientific journal)

    Publisher: Springer Science and Business Media LLC

  74. An infectivity-enhancing site on the SARS-CoV-2 spike protein targeted by antibodies

    Yafei Liu, Wai Tuck Soh, Jun ichi Kishikawa, Mika Hirose, Emi E. Nakayama, Songling Li, Miwa Sasai, Tatsuya Suzuki, Asa Tada, Akemi Arakawa, Sumiko Matsuoka, Kanako Akamatsu, Makoto Matsuda, Chikako Ono, Shiho Torii, Kazuki Kishida, Hui Jin, Wataru Nakai, Noriko Arase, Atsushi Nakagawa, Maki Matsumoto, Yukoh Nakazaki, Yasuhiro Shindo, Masako Kohyama, Keisuke Tomii, Koichiro Ohmura, Shiro Ohshima, Toru Okamoto, Masahiro Yamamoto, Hironori Nakagami, Yoshiharu Matsuura, Takayuki Kato, Masato Okada, Daron M. Standley, Tatsuo Shioda, Hisashi Arase

    Cell　Vol. 184　No. 13　p. 3452-3.47E+21　2021/06/24　Research paper (scientific journal)

  75. Hepatitis C virus modulates signal peptide peptidase to alter host protein processing.

    Junki Hirano, Sachiyo Yoshio, Yusuke Sakai, Li Songling, Tatsuya Suzuki, Yumi Itoh, He Zhang, David Virya Chen, Saori Haga, Hiroko Oomori, Takahiro Kodama, Yusuke Maeda, Yoshihiro Ono, Yu Takahashi, Daron M Standley, Masahiro Yamamoto, Kohji Moriishi, Kyoji Moriya, Tatsuya Kanto, Tetsuo Takehara, Kazuhiko Koike, Yoshiharu Matsuura, Toru Okamoto

    Proceedings of the National Academy of Sciences of the United States of America　Vol. 118　No. 22　2021/06/01　Research paper (scientific journal)

  76. Toxoplasma gondii GRA60 is an effector protein that modulates host cell autonomous immunity and contributes to virulence.

    Mary Akinyi Nyonda, Pierre-Mehdi Hammoudi, Shu Ye, Jessica Maire, Jean-Baptiste Marq, Masahiro Yamamoto, Dominique Soldati-Favre

    Cellular microbiology　Vol. 23　No. 2　2021/02　Research paper (scientific journal)

  77. Osteoclast fusion and bone loss are restricted by interferon inducible guanylate binding proteins.

    David E Place, R K Subbarao Malireddi, Jieun Kim, Peter Vogel, Masahiro Yamamoto, Thirumala-Devi Kanneganti

    Nature communications　Vol. 12　No. 1　p. 496-496　2021/01/21　Research paper (scientific journal)

  78. Anti-CoVid19 plasmid DNA vaccine induces a potent immune response in rodents by Pyro-drive Jet Injector intradermal inoculation

    Tomoyuki Nishikawa, Chin Yang Chang, Jiayu A Tai, Hiroki Hayashi, Jiao Sun, Shiho Torii, Chikako Ono, Yoshiharu Matsuura, Ryoko Ide, Junichi Mineno, Miwa Sasai, Masahiro Yamamoto, Hironori Nakagami, Kunihiko Yamashita

    2021/01/14

    Publisher: Cold Spring Harbor Laboratory

  79. ESRRA (estrogen related receptor alpha) is a critical regulator of intestinal homeostasis through activation of autophagic flux via gut microbiota.

    Sup Kim, June-Young Lee, Seul Gi Shin, Jin Kyung Kim, Prashanta Silwal, Young Jae Kim, Na-Ri Shin, Pil Soo Kim, Minho Won, Sang-Hee Lee, Soo Yeon Kim, Miwa Sasai, Masahiro Yamamoto, Jin-Man Kim, Jin-Woo Bae, Eun-Kyeong Jo

    Autophagy　Vol. 17　No. 10　p. 2856-2875　2020/11/10　Research paper (scientific journal)

  80. Irgm2 and Gate-16 cooperatively dampen Gram-negative bacteria-induced caspase-11 response.

    Elif Eren, Rémi Planès, Salimata Bagayoko, Pierre-Jean Bordignon, Karima Chaoui, Audrey Hessel, Karin Santoni, Miriam Pinilla, Brice Lagrange, Odile Burlet-Schiltz, Jonathan C Howard, Thomas Henry, Masahiro Yamamoto, Etienne Meunier

    EMBO reports　Vol. 21　No. 11　2020/11/05　Research paper (scientific journal)

  81. LC3 lipidation is essential for TFEB activation during the lysosomal damage response to kidney injury

    Shuhei Nakamura, Saki Shigeyama, Satoshi Minami, Takayuki Shima, Shiori Akayama, Tomoki Matsuda, Alessandra Esposito, Gennaro Napolitano, Akiko Kuma, Tomoko Namba-Hamano, Jun Nakamura, Kenichi Yamamoto, Miwa Sasai, Ayaka Tokumura, Mika Miyamoto, Yukako Oe, Toshiharu Fujita, Seigo Terawaki, Atsushi Takahashi, Maho Hamasaki, Masahiro Yamamoto, Yukinori Okada, Masaaki Komatsu, Takeharu Nagai, Yoshitsugu Takabatake, Haoxing Xu, Yoshitaka Isaka, Andrea Ballabio, Tamotsu Yoshimori

    Nature Cell Biology　Vol. 22　No. 10　p. 1252-1263　2020/10/01　Research paper (scientific journal)

  82. Human GBP1 Differentially Targets Salmonella and Toxoplasma to License Recognition of Microbial Ligands and Caspase-Mediated Death.

    Daniel Fisch, Barbara Clough, Marie-Charlotte Domart, Vesela Encheva, Hironori Bando, Ambrosius P Snijders, Lucy M Collinson, Masahiro Yamamoto, Avinash R Shenoy, Eva-Maria Frickel

    Cell reports　Vol. 32　No. 6　p. 108008-108008　2020/08/11　Research paper (scientific journal)

  83. Naïve CD8 T cell IFNγ responses to a vacuolar antigen are regulated by an inflammasome-independent NLRP3 pathway and Toxoplasma gondii ROP5.

    Angel K Kongsomboonvech, Felipe Rodriguez, Anh L Diep, Brandon M Justice, Brayan E Castallanos, Ana Camejo, Debanjan Mukhopadhyay, Gregory A Taylor, Masahiro Yamamoto, Jeroen P J Saeij, Michael L Reese, Kirk D C Jensen

    PLoS pathogens　Vol. 16　No. 8　2020/08　Research paper (scientific journal)

  84. Guanylate Binding Proteins Restrict Leishmania donovani Growth in Nonphagocytic Cells Independent of Parasitophorous Vacuolar Targeting.

    Arun Kumar Haldar, Utsav Nigam, Masahiro Yamamoto, Jörn Coers, Neena Goyal

    mBio　Vol. 11　No. 4　p. 1-19　2020/07/28　Research paper (scientific journal)

  85. Guanylate-Binding Proteins Are Critical for Effective Control of Francisella tularensis Strains in a Mouse Co-Culture System of Adaptive Immunity.

    Nasibeh Mohammadi, Helena Lindgren, Igor Golovliov, Kjell Eneslätt, Masahiro Yamamoto, Amandine Martin, Thomas Henry, Anders Sjöstedt

    Frontiers in cellular and infection microbiology　Vol. 10　p. 594063-594063　2020　Research paper (scientific journal)

  86. Interferon inducible GBPs restrict Burkholderia thailandensis motility induced cell-cell fusion

    David E. Place, Benoit Briard, Parimal Samir, Rajendra Karki, Anannya Bhattacharya, Clifford S. Guy, Jennifer L. Peters, Sharon Frase, Peter Vogel, Geoffrey Neale, Masahiro Yamamoto, Thirumala Devi Kanneganti

    PLoS Pathogens　Vol. 16　No. 3　2020　Research paper (scientific journal)

  87. Toxoplasma gondii Dense Granule Proteins 7, 14, and 15 Are Involved in Modification and Control of the Immune Response Mediated via NF-κB Pathway.

    Fumiaki Ihara, Ragab M Fereig, Yuu Himori, Kyohko Kameyama, Kosuke Umeda, Sachi Tanaka, Rina Ikeda, Masahiro Yamamoto, Yoshifumi Nishikawa

    Frontiers in immunology　Vol. 11　p. 1709-1709　2020　Research paper (scientific journal)

  88. Innate, adaptive, and cell-autonomous immunity against Toxoplasma gondii infection.

    Miwa Sasai, Masahiro Yamamoto

    Experimental & molecular medicine　Vol. 51　No. 12　p. 1-10　2019/12/11　Research paper (scientific journal)

  89. Phospholipase C-β1 potentiates glucose-stimulated insulin secretion

    Hyeon Jeong Hwang, Yong Ryoul Yang, Hye Yun Kim, Yoonji Choi, Kyoung Su Park, Ho Lee, Ji Su Ma, Masahiro Yamamoto, Jaeyoon Kim, Young Chan Chae, Jang Hyun Choi, Lucio Cocco, Per Olof Berggren, Hyun Jun Jang, Pann Ghill Suh

    FASEB Journal　Vol. 33　No. 10　p. 10668-10679　2019/10/01　Research paper (scientific journal)

  90. Metabolic adaptation to glycolysis is a basic defense mechanism of macrophages for Mycobacterium tuberculosis infection

    Mayuko Osada-Oka, Nobuhito Goda, Hiroyuki Saiga, Masahiro Yamamoto, Kiyoshi Takeda, Yuriko Ozeki, Takehiro Yamaguchi, Tomoyoshi Soga, Yu Tateishi, Katsuyuki Miura, Daisuke Okuzaki, Kazuo Kobayashi, Sohkichi Matsumoto

    International Immunology　Vol. 31　No. 12　p. 781-793　2019/08/01　Research paper (scientific journal)

  91. Human GBP1 is a microbe-specific gatekeeper of macrophage apoptosis and pyroptosis

    Daniel Fisch, Hironori Bando, Barbara Clough, Veit Hornung, Masahiro Yamamoto, Avinash R. Shenoy, Eva Maria Frickel

    EMBO Journal　Vol. 38　No. 13　2019/07/01　Research paper (scientific journal)

  92. Human GBP1 is a microbe-specific gatekeeper of macrophage apoptosis and pyroptosis.

    Daniel Fisch, Hironori Bando, Barbara Clough, Veit Hornung, Masahiro Yamamoto, Avinash R Shenoy, Eva-Maria Frickel

    The EMBO journal　Vol. 38　No. 13　2019/07/01　Research paper (scientific journal)

  93. Cholera toxin B induces interleukin-1β production from resident peritoneal macrophages through the pyrin inflammasome as well as the NLRP3 inflammasome

    Takashi Orimo, Izumi Sasaki, Hiroaki Hemmi, Toshiya Ozasa, Yuri Fukuda-Ohta, Tomokazu Ohta, Mio Morinaka, Mariko Kitauchi, Takako Yamaguchi, Yayoi Sato, Takashi Tanaka, Katsuaki Hoshino, Kei Ichi Katayama, Shinji Fukuda, Kensuke Miyake, Masahiro Yamamoto, Takashi Satoh, Koichi Furukawa, Etsushi Kuroda, Ken J. Ishii, Kiyoshi Takeda, Tsuneyasu Kaisho

    International Immunology　Vol. 31　No. 10　p. 657-668　2019/05/27　Research paper (scientific journal)

  94. USP15 participates in hepatitis C virus propagation through regulation of viral RNA translation and lipid droplet formation

    Shinji Kusakabe, Tatsuya Suzuki, Yukari Sugiyama, Saori Haga, Kanako Horike, Makoto Tokunaga, Junki Hirano, He Zhang, David Virya Chen, Hanako Ishiga, Yasumasa Komoda, Chikako Ono, Takasuke Fukuhara, Masahiro Yamamoto, Masahito Ikawa, Takashi Satoh, Shizuo Akira, Tomohisa Tanaka, Kohji Moriishi, Moto Fukai, Akinobu Taketomi, Sachiyo Yoshio, Tatsuya Kanto, Tetsuro Suzuki, Toru Okamoto, Yoshiharu Matsuura

    Journal of Virology　Vol. 93　No. 6　2019/03/01　Research paper (scientific journal)

  95. Fungal ligands released by innate immune effectors promote inflammasome activation during Aspergillus fumigatus infection

    Benoit Briard, Rajendra Karki, R. K.Subbarao Malireddi, Anannya Bhattacharya, David E. Place, Jayadev Mavuluri, Jennifer L. Peters, Peter Vogel, Masahiro Yamamoto, Thirumala Devi Kanneganti

    Nature Microbiology　Vol. 4　No. 2　p. 316-327　2019/02/01　Research paper (scientific journal)

  96. GABAergic signaling linked to autophagy enhances host protection against intracellular bacterial infections

    Jin Kyung Kim, Yi Sak Kim, Hye Mi Lee, Hyo Sun Jin, Chiranjivi Neupane, Sup Kim, Sang Hee Lee, Jung Joon Min, Miwa Sasai, Jae Ho Jeong, Seong Kyu Choe, Jin Man Kim, Masahiro Yamamoto, Hyon E. Choy, Jin Bong Park, Eun Kyeong Jo

    Nature Communications　Vol. 9　No. 1　p. 4184-4184　2018/12/01　Research paper (scientific journal)

  97. Guanylate binding proteins facilitate caspase-11-dependent pyroptosis in response to type 3 secretion system-negative Pseudomonas aeruginosa

    Arjun Balakrishnan, Rajendra Karki, Brent Berwin, Masahiro Yamamoto, Thirumala Devi Kanneganti

    Cell Death Discovery　Vol. 4　No. 1　p. 3-3　2018/12/01　Research paper (scientific journal)

  98. Molecular mechanisms of Streptococcus pneumoniae-targeted autophagy via pneumolysin, Golgi-resident Rab41, and Nedd4-1-mediated K63-linked ubiquitination

    Michinaga Ogawa, Ryuta Matsuda, Naoki Takada, Mikado Tomokiyo, Shouji Yamamoto, Sayaka Shizukusihi, Toshiyuki Yamaji, Yuko Yoshikawa, Mitsutaka Yoshida, Isei Tanida, Masato Koike, Miyo Murai, Hidetoshi Morita, Haruko Takeyama, Akihide Ryo, Jun Lin Guan, Masahiro Yamamoto, Jun ichiro Inoue, Toru Yanagawa, Mitsunori Fukuda, Hiroshi Kawabe, Makoto Ohnishi

    Cellular Microbiology　Vol. 20　No. 8　2018/08/01　Research paper (scientific journal)

  99. Constitutive Interferon Maintains GBP Expression Required for Release of Bacterial Components Upstream of Pyroptosis and Anti-DNA Responses

    Beiyun C. Liu, Joseph Sarhan, Alexander Panda, Hayley I. Muendlein, Vladimir Ilyukha, Jörn Coers, Masahiro Yamamoto, Ralph R. Isberg, Alexander Poltorak

    Cell Reports　Vol. 24　No. 1　p. 155-168.e5　2018/07/03　Research paper (scientific journal)

  100. A nonpyroptotic ifn-g–triggered cell death mechanism in nonphagocytic cells promotes salmonella clearance in vivo

    Justin P. Ingram, Sarah Tursi, Ting Zhang, Wei Guo, Chaoran Yin, Meghan A. Wynosky-Dolfi, Joris Van der Heijden, Kathy Q. Cai, Masahiro Yamamoto, B. Brett Finlay, Igor E. Brodsky, Sergei I. Grivennikov, Çagla Tükel, Siddharth Balachandran

    Journal of Immunology　Vol. 200　No. 10　p. 3626-3634　2018/05/15　Research paper (scientific journal)

  101. LPS targets host guanylate-binding proteins to the bacterial outer membrane for non-canonical inflammasome activation

    José Carlos Santos, Mathias S. Dick, Brice Lagrange, Daniel Degrandi, Klaus Pfeffer, Masahiro Yamamoto, Etienne Meunier, Pawel Pelczar, Thomas Henry, Petr Broz

    EMBO Journal　Vol. 37　No. 6　2018/03/15　Research paper (scientific journal)

  102. Host immune responses to Toxoplasma gondii.

    Miwa Sasai, Ariel Pradipta, Masahiro Yamamoto

    International immunology　Vol. 30　No. 3　p. 113-119　2018/03/10　Research paper (scientific journal)

  103. Introduction: Interactions between the immune system and parasites special issue

    Cevayir Coban, Masahiro Yamamoto

    International Immunology　Vol. 30　No. 3　p. 91-91　2018/03/01　Research paper (scientific journal)

  104. Characterization of SPP inhibitors suppressing propagation of HCV and protozoa.

    Junki Hirano, Toru Okamoto, Yukari Sugiyama, Tatsuya Suzuki, Shinji Kusakabe, Makoto Tokunaga, Takasuke Fukuhara, Miwa Sasai, Takahiro Tougan, Yasue Matsunaga, Kazuo Yamashita, Yusuke Sakai, Masahiro Yamamoto, Toshihiro Horii, Daron M Standley, Kohji Moriishi, Kyoji Moriya, Kazuhiko Koike, Yoshiharu Matsuura

    Proceedings of the National Academy of Sciences of the United States of America　Vol. 114　No. 50　p. E10782-E10791-E10791　2017/12/12　Research paper (scientific journal)

  105. Critical role of CREBH-mediated induction of transforming growth factor β2 by hepatitis C virus infection in fibrogenic responses in hepatic stellate cells

    Takeshi Chida, Masahiko Ito, Kenji Nakashima, Yumi Kanegae, Takuya Aoshima, Shuji Takabayashi, Kazuhito Kawata, Yoshimi Nakagawa, Masahiro Yamamoto, Hitoshi Shimano, Tomokazu Matsuura, Yoshimasa Kobayashi, Takafumi Suda, Tetsuro Suzuki

    Hepatology　Vol. 66　No. 5　p. 1430-1443　2017/11/01　Research paper (scientific journal)

  106. IFN-γ extends the immune functions of Guanylate Binding Proteins to inflammasome-independent antibacterial activities during Francisella novicida infection

    Pierre Wallet, Sacha Benaoudia, Amandine Mosnier, Brice Lagrange, Amandine Martin, Helena Lindgren, Igor Golovliov, Fanny Michal, Pauline Basso, Sophia Djebali, Angelina Provost, Omran Allatif, Etienne Meunier, Petr Broz, Masahiro Yamamoto, Bénédicte F. Py, Eric Faudry, Anders Sjöstedt, Thomas Henry

    PLoS Pathogens　Vol. 13　No. 10　2017/10　Research paper (scientific journal)

  107. Inflammasome activation by bacterial outer membrane vesicles requires guanylate binding proteins

    Ryan Finethy, Sarah Luoma, Nichole Orench-Rivera, Eric M. Feeley, Arun K. Haldar, Masahiro Yamamoto, Thirumala Devi Kanneganti, Meta J. Kuehn, Jörn Coers

    mBio　Vol. 8　No. 5　2017/09　Research paper (scientific journal)

  108. Viral Replication Complexes Are Targeted by LC3-Guided Interferon-Inducible GTPases

    Scott B. Biering, Jayoung Choi, Rachel A. Halstrom, Hailey M. Brown, Wandy L. Beatty, Sanghyun Lee, Broc T. McCune, Erin Dominici, Lelia E. Williams, Robert C. Orchard, Craig B. Wilen, Masahiro Yamamoto, Jörn Coers, Gregory A. Taylor, Seungmin Hwang

    Cell Host and Microbe　Vol. 22　No. 1　p. 74-85.e7　2017/07/12　Research paper (scientific journal)

  109. Guanylate binding proteins regulate inflammasome activation in response to hyperinjected Yersinia translocon components

    Erin E. Zwack, Eric M. Feeley, Amanda R. Burton, Baofeng Hu, Masahiro Yamamoto, Thirumala Devi Kanneganti, James B. Bliska, Jörn Coers, Igor E. Brodsky

    Infection and Immunity　Vol. 85　No. 10　2017　Research paper (scientific journal)

  110. The thalamic mGluR1-PLCβ4 pathway is critical in sleep architecture

    Joohyeon Hong, Jungryun Lee, Kiyeong Song, Go Eun Ha, Yong Ryoul Yang, Ji Su Ma, Masahiro Yamamoto, Hee Sup Shin, Pann Ghill Suh, Eunji Cheong

    Molecular Brain　Vol. 9　No. 1　p. 100-100　2016/12/21　Research paper (scientific journal)

  111. IRGB10 Liberates Bacterial Ligands for Sensing by the AIM2 and Caspase-11-NLRP3 Inflammasomes

    Si Ming Man, Rajendra Karki, Miwa Sasai, David E. Place, Sannula Kesavardhana, Jamshid Temirov, Sharon Frase, Qifan Zhu, R. K.Subbarao Malireddi, Teneema Kuriakose, Jennifer L. Peters, Geoffrey Neale, Scott A. Brown, Masahiro Yamamoto, Thirumala Devi Kanneganti

    Cell　Vol. 167　No. 2　p. 382-396.e17　2016/10/06　Research paper (scientific journal)

  112. The P2X4 receptor is required for neuroprotection via ischemic preconditioning

    Tomohiko Ozaki, Rieko Muramatsu, Miwa Sasai, Masahiro Yamamoto, Yoshiaki Kubota, Toshiyuki Fujinaka, Toshiki Yoshimine, Toshihide Yamashita

    Scientific Reports　Vol. 6　2016/05/13　Research paper (scientific journal)

  113. TRC8-dependent degradation of hepatitis C virus immature core protein regulates viral propagation and pathogenesis

    Sayaka Aizawa, Toru Okamoto, Yukari Sugiyama, Takahisa Kouwaki, Ayano Ito, Tatsuya Suzuki, Chikako Ono, Takasuke Fukuhara, Masahiro Yamamoto, Masayasu Okochi, Nobuhiko Hiraga, Michio Imamura, Kazuaki Chayama, Ryosuke Suzuki, Ikuo Shoji, Kohji Moriishi, Kyoji Moriya, Kazuhiko Koike, Yoshiharu Matsuura

    Nature Communications　Vol. 7　2016/05/04　Research paper (scientific journal)

  114. Lypd8 promotes the segregation of flagellated microbiota and colonic epithelia

    Ryu Okumura, Takashi Kurakawa, Takashi Nakano, Hisako Kayama, Makoto Kinoshita, Daisuke Motooka, Kazuyoshi Gotoh, Taishi Kimura, Naganori Kamiyama, Takashi Kusu, Yoshiyasu Ueda, Hong Wu, Hideki Iijima, Soumik Barman, Hideki Osawa, Hiroshi Matsuno, Junichi Nishimura, Yusuke Ohba, Shota Nakamura, Tetsuya Iida, Masahiro Yamamoto, Eiji Umemoto, Koichi Sano, Kiyoshi Takeda

    Nature　Vol. 532　No. 7597　p. 117-121　2016/04　Research paper (scientific journal)

  115. Fundamental Roles of the Golgi-Associated Toxoplasma Aspartyl Protease, ASP5, at the Host-Parasite Interface.

    Pierre-Mehdi Hammoudi, Damien Jacot, Christina Mueller, Manlio Di Cristina, Sunil Kumar Dogga, Jean-Baptiste Marq, Julia Romano, Nicolò Tosetti, Juan Dubrot, Yalin Emre, Matteo Lunghi, Isabelle Coppens, Masahiro Yamamoto, Daniel Sojka, Paco Pino, Dominique Soldati-Favre

    PLoS pathogens　Vol. 11　No. 10　2015/10　Research paper (scientific journal)

  116. Erratum: Class-specific regulation of pro-inflammatory genes by MyD88 pathways and IκBζ (The Journal of Biological Chemistry (2008) 283 (12468-12477))

    Hisako Kayama, Vladimir R. Ramirez-Carrozzi, Masahiro Yamamoto, Taketoshi Mizutani, Hirotaka Kuwata, Hideo Iba, Makoto Matsumoto, Kenya Honda, Stephen T. Smale, Kiyoshi Takeda

    Journal of Biological Chemistry　Vol. 290　No. 37　p. 22446-22446　2015/09/11　Research paper (scientific journal)

  117. MTOR complex signaling through the SEMA4A-plexin B2 axis is required for optimal activation and differentiation of CD8+ T cells

    Daisuke Ito, Satoshi Nojima, Masayuki Nishide, Tatsusada Okuno, Hyota Takamatsu, Sujin Kang, Tetsuya Kimura, Yuji Yoshida, Keiko Morimoto, Yohei Maeda, Takashi Hosokawa, Toshihiko Toyofuku, Jun Ohshima, Daisuke Kamimura, Masahiro Yamamoto, Masaaki Murakami, Eiichi Morii, Hiromi Rakugi, Yoshitaka Isaka, Atsushi Kumanogoh

    Journal of Immunology　Vol. 195　No. 3　p. 934-943　2015/08/01　Research paper (scientific journal)

  118. The transcription factor IRF1 and guanylate-binding proteins target activation of the AIM2 inflammasome by Francisella infection

    Si Ming Man, Rajendra Karki, R. K.Subbarao Malireddi, Geoffrey Neale, Peter Vogel, Masahiro Yamamoto, Mohamed Lamkanfi, Thirumala Devi Kanneganti

    Nature Immunology　Vol. 16　No. 5　p. 467-475　2015/05/28　Research paper (scientific journal)

  119. Guanylate-binding proteins promote activation of the AIM2 inflammasome during infection with Francisella novicida

    Etienne Meunier, Pierre Wallet, Roland F. Dreier, Stéphanie Costanzo, Leonie Anton, Sebastian Rühl, Sébastien Dussurgey, Mathias S. Dick, Anne Kistner, Mélanie Rigard, Daniel Degrandi, Klaus Pfeffer, Masahiro Yamamoto, Thomas Henry, Petr Broz

    Nature Immunology　Vol. 16　No. 5　p. 476-484　2015/05/28　Research paper (scientific journal)

  120. Erratum: Class-specific regulation of pro-inflammatory genes by MyD88 pathways and IκBζ (The Journal of Biological Chemistry (2008) 283 (12468-12477)

    Hisako Kayama, Vladimir R. Ramirez-Carrozzi, Masahiro Yamamoto, Taketoshi Mizutani, Hirotaka Kuwata, Hideo Iba, Makoto Matsumoto, Kenya Honda, Stephen T. Smale, Kiyoshi Takeda

    Journal of Biological Chemistry　Vol. 290　No. 8　p. 4815-4815　2015/02/20　Research paper (scientific journal)

  121. Guanylate binding proteins enable rapid activation of canonical and noncanonical inflammasomes in Chlamydia-infected macrophages

    Ryan Finethy, Ine Jorgensen, Arun K. Haldar, Marcel R. De Zoete, Till Strowig, Richard A. Flavell, Masahiro Yamamoto, Uma M. Nagarajan, Edward A. Miao, Jörn Coers

    Infection and Immunity　Vol. 83　No. 12　p. 4740-4749　2015　Research paper (scientific journal)

  122. Amphipathic α-Helices in Apolipoproteins Are Crucial to the Formation of Infectious Hepatitis C Virus Particles

    Takasuke Fukuhara, Masami Wada, Shota Nakamura, Chikako Ono, Mai Shiokawa, Satomi Yamamoto, Takashi Motomura, Toru Okamoto, Daisuke Okuzaki, Masahiro Yamamoto, Izumu Saito, Takaji Wakita, Kazuhiko Koike, Yoshiharu Matsuura

    PLoS Pathogens　Vol. 10　No. 12　2014/12/01　Research paper (scientific journal)

  123. Guanylate binding proteins promote caspase-11-dependent pyroptosis in response to cytoplasmic LPS

    Danielle M. Pilla, Jon A. Hagar, Arun K. Haldar, Ashley K. Mason, Daniel Degrandi, Klaus Pfeffer, Robert K. Ernst, Masahiro Yamamoto, Edward A. Miao, Jörn Coers

    Proceedings of the National Academy of Sciences of the United States of America　Vol. 111　No. 16　p. 6046-6051　2014/04　Research paper (scientific journal)

  124. Innate immune response induced by baculovirus attenuates transgene expression in mammalian cells

    Chikako Ono, Akinori Ninomiya, Satomi Yamamoto, Takayuki Abe, Xiauyu Wen, Takasuke Fukuhara, Miwa Sasai, Masahiro Yamamoto, Tatsuya Saitoh, Takashi Satoh, Taro Kawai, Ken J. Ishii, Shizuo Akira, Toru Okamoto, Yoshiharu Matsuura

    Journal of Virology　Vol. 88　No. 4　p. 2157-2167　2014/02　Research paper (scientific journal)

  125. Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPases

    Etienne Meunier, Mathias S. Dick, Roland F. Dreier, Nura Schürmann, Daniela Kenzelmann Broz, Søren Warming, Merone Roose-Girma, Dirk Bumann, Nobuhiko Kayagaki, Kiyoshi Takeda, Masahiro Yamamoto, Petr Broz

    Nature　Vol. 509　No. 7500　p. 366-370　2014　Research paper (scientific journal)

  126. The E2-like conjugation enzyme Atg3 promotes binding of IRG and Gbp proteins to Chlamydia- and Toxoplasma-containing vacuoles and host resistance.

    Arun K Haldar, Anthony S Piro, Danielle M Pilla, Masahiro Yamamoto, Jörn Coers

    PloS one　Vol. 9　No. 1　2014　Research paper (scientific journal)

  127. Erratum: NF-κB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1 (Proceedings of the National Academy of Sciences of the United States of America (2007) 110 (3372-3377) DOI: 10.1073/pnas.0608100104)

    Sinead M. Miggin, Eva Pålsson-McDermott, Aisling Dunne, Caroline Jefferies, Emmanuel Pinteaux, Kathy Banahan, Caroline Murphy, Paul Moynagh, Masahiro Yamamoto, Shizuo Akira, Nancy Rothwell, Douglas Golenbock, Katherine A. Fitzgerald, Luke A.J. O'Neill

    Proceedings of the National Academy of Sciences of the United States of America　Vol. 110　No. 43　2013/10/22　Research paper (scientific journal)

  128. Toll-like receptor 3 and 4 signalling through the TRIF and TRAM adaptors in haematopoietic cells promotes atherosclerosis

    Anna M. Lundberg, Daniel F.J. Ketelhuth, Maria E. Johansson, Norbert Gerdes, Sang Liu, Masahiro Yamamoto, Shizuo Akira, Göran K. Hansson

    Cardiovascular Research　Vol. 99　No. 2　p. 364-373　2013/07/15　Research paper (scientific journal)

  129. Subversion of host cellular functions by the apicomplexan parasites.

    Louise E Kemp, Masahiro Yamamoto, Dominique Soldati-Favre

    FEMS microbiology reviews　Vol. 37　No. 4　p. 607-31　2013/07　Research paper (scientific journal)

  130. Pathogen recognition receptors: Ligands and signaling pathways by toll-like receptors

    Miwa Sasai, Masahiro Yamamoto

    International Reviews of Immunology　Vol. 32　No. 2　p. 116-133　2013/04

  131. Critical role of Trib1 in differentiation of tissue-resident M2-like macrophages

    Takashi Satoh, Hiroyasu Kidoya, Hisamichi Naito, Masahiro Yamamoto, Naoki Takemura, Katsuhiro Nakagawa, Yoshichika Yoshioka, Eiichi Morii, Nobuyuki Takakura, Osamu Takeuchi, Shizuo Akira

    Nature　Vol. 495　No. 7442　p. 524-528　2013/03/28　Research paper (scientific journal)

  132. CREBH Determines the Severity of Sulpyrine-Induced Fatal Shock

    Naganori Kamiyama, Masahiro Yamamoto, Hiroyuki Saiga, Ji Su Ma, Jun Ohshima, Sakaaki Machimura, Miwa Sasai, Taishi Kimura, Yoshiyasu Ueda, Hisako Kayama, Kiyoshi Takeda

    PLoS ONE　Vol. 8　No. 2　2013/02/07　Research paper (scientific journal)

  133. Ecto-nucleoside triphosphate diphosphohydrolase 7 controls Th17 cell responses through regulation of luminal ATP in the small intestine

    Takashi Kusu, Hisako Kayama, Makoto Kinoshita, Seong Gyu Jeon, Yoshiyasu Ueda, Yoshiyuki Goto, Ryu Okumura, Hiroyuki Saiga, Takashi Kurakawa, Kayo Ikeda, Yuichi Maeda, Jun Ichi Nishimura, Yasunobu Arima, Koji Atarashi, Kenya Honda, Masaaki Murakami, Jun Kunisawa, Hiroshi Kiyono, Meinoshin Okumura, Masahiro Yamamoto, Kiyoshi Takeda

    Journal of Immunology　Vol. 190　No. 2　p. 774-783　2013/01/15　Research paper (scientific journal)

  134. Ifit1 inhibits japanese encephalitis virus replication through binding to 5= capped 2'-o unmethylated RNA

    Taishi Kimura, Hiroshi Katoh, Hisako Kayama, Hiroyuki Saiga, Megumi Okuyama, Toru Okamoto, Eiji Umemoto, Yoshiharu Matsuur, Masahiro Yamamoto, Kiyoshi Takeda

    Journal of Virology　Vol. 87　No. 18　p. 9997-10003　2013　Research paper (scientific journal)

  135. Critical role of AIM2 in Mycobacterium tuberculosis infection

    Hiroyuki Saiga, Shoko Kitada, Yosuke Shimada, Naganori Kamiyama, Megumi Okuyama, Masahiko Makino, Masahiro Yamamoto, Kiyoshi Takeda

    International Immunology　Vol. 24　No. 10　p. 637-644　2012/10　Research paper (scientific journal)

  136. Probiotic Bifidobacterium breve induces IL-10-producing Tr1 cells in the colon

    Seong Gyu Jeon, Hisako Kayama, Yoshiyasu Ueda, Takuya Takahashi, Takashi Asahara, Hirokazu Tsuji, Noriko M. Tsuji, Hiroshi Kiyono, Ji Su Ma, Takashi Kusu, Ryu Okumura, Hiromitsu Hara, Hiroki Yoshida, Masahiro Yamamoto, Koji Nomoto, Kiyoshi Takeda

    PLoS Pathogens　Vol. 8　No. 5　2012/05　Research paper (scientific journal)

  137. Intestinal CX <inf>3</inf>C chemokine receptor 1 high (CX <inf>3</inf>CR1 high) myeloid cells prevent T-cell-dependent colitis

    Hisako Kayama, Yoshiyasu Ueda, Yukihisa Sawa, Seong Gyu Jeon, Ji Su Ma, Ryu Okumura, Atsuko Kubo, Masaru Ishii, Taku Okazaki, Masaaki Murakami, Masahiro Yamamoto, Hideo Yagita, Kiyoshi Takeda

    Proceedings of the National Academy of Sciences of the United States of America　Vol. 109　No. 13　p. 5010-5015　2012/03/27　Research paper (scientific journal)

  138. Inhibition of ATF6β-dependent host adaptive immune response by a toxoplasma virulence factor ROP18

    Masahiro Yamamoto, Kiyoshi Takeda

    Virulence　Vol. 3　No. 1　p. 77-80　2012　Research paper (scientific journal)

  139. α-fetoprotein impairs activation of NK cells by inhibiting the function of dendritic cells

    Masashi Yamamoto, Tomohide Tatsumi, Takuya Miyagi, Hinako Tsunematsu, Hiroshi Aketa, Atsushi Hosui, Tatsuya Kanto, Naoki Hiramatsu, Norio Hayashi, Tetsuo Takehara

    Clinical and Experimental Immunology　Vol. 165　No. 2　p. 211-219　2011/08　Research paper (scientific journal)

  140. A method for the generation of conditional gene-targeted mice

    Masahiro Yamamoto, Kiyoshi Takeda

    Methods in Molecular Biology　Vol. 757　p. 399-410　2011　Research paper (scientific journal)

  141. Trib1 is a lipid- and myocardial infarction-associated gene that regulates hepatic lipogenesis and VLDL production in mice

    Ralph Burkhardt, Sue Anne Toh, William R. Lagor, Andrew Birkeland, Michael Levin, Xiaoyu Li, Megan Robblee, Victor D. Fedorov, Masahiro Yamamoto, Takashi Satoh, Shizuo Akira, Sekar Kathiresan, Jan L. Breslow, Daniel J. Rader

    Journal of Clinical Investigation　Vol. 120　No. 12　p. 4410-4414　2010/12/01　Research paper (scientific journal)

  142. Commensal microbiota induce LPS hyporesponsiveness in colonic macrophages via the production of IL-10

    Yoshiyasu Ueda, Hisako Kayama, Seong Gyu Jeon, Takashi Kusu, Yoshitaka Isaka, Hiromi Rakugi, Masahiro Yamamoto, Kiyoshi Takeda

    International Immunology　Vol. 22　No. 12　p. 953-962　2010/12　Research paper (scientific journal)

  143. Control of adipose tissue inflammation through TRB1

    Anke Ostertag, Allan Jones, Adam J. Rose, Maria Liebert, Stefan Kleinsorg, Anja Reimann, Alexandros Vegiopoulos, Mauricio Berriel Diaz, Daniela Strzoda, Masahiro Yamamoto, Takashi Satoh, Shizuo Akira, Stephan Herzig

    Diabetes　Vol. 59　No. 8　p. 1991-2000　2010/08　Research paper (scientific journal)

  144. A novel in vivo inducible dendritic cell ablation model in mice

    Megumi Okuyama, Hisako Kayama, Koji Atarashi, Hiroyuki Saiga, Taishi Kimura, Ari Waisman, Masahiro Yamamoto, Kiyoshi Takeda

    Biochemical and Biophysical Research Communications　Vol. 397　No. 3　p. 559-563　2010/07　Research paper (scientific journal)

  145. IκBη regulates T<inf>H</inf> 17 development by cooperating with ROR nuclear receptors

    Kazuo Okamoto, Yoshiko Iwai, Masatsugu Oh-Hora, Masahiro Yamamoto, Tomohiro Morio, Kazuhiro Aoki, Keiichi Ohya, Anton M. Jetten, Shizuo Akira, Tatsushi Muta, Hiroshi Takayanagi

    Nature　Vol. 464　No. 7293　p. 1381-1385　2010/04　Research paper (scientific journal)

  146. Current views of toll-like receptor signaling pathways

    Kiyoshi Takeda, Masahiro Yamamoto

    Gastroenterology Research and Practice　Vol. 2010　p. 240365-240365　2010

  147. Regulation of hematopoiesis by the K63-specific ubiquitin-conjugating enzyme Ubc13

    Xuefeng Wu, Masahiro Yamamoto, Shizuo Akira, Shao Cong Sun

    Proceedings of the National Academy of Sciences of the United States of America　Vol. 106　No. 49　p. 20836-20841　2009/12/08　Research paper (scientific journal)

  148. Toll-like receptor 4 signalling through MyD88 is essential to control Salmonella enterica serovar Typhimurium infection, but not for the initiation of bacterial clearance

    Suzanne Talbot, Sabine Tötemeyer, Masahiro Yamamoto, Shizuo Akira, Katherine Hughes, David Gray, Tom Barr, Pietro Mastroeni, Duncan J. Maskell, Clare E. Bryant

    Immunology　Vol. 128　No. 4　p. 472-483　2009/12　Research paper (scientific journal)

  149. Two mechanistically and temporally distinct NF-κB activation pathways in IL-1 signaling

    Kohsuke Yamazaki, Jin Gohda, Atsuhiro Kanayama, Yusei Miyamoto, Hiroaki Sakurai, Masahiro Yamamoto, Shizuo Akira, Hidetoshi Hayashi, Bing Su, Jun Ichiro Inoue

    Science Signaling　Vol. 2　No. 93　2009/10/20　Research paper (scientific journal)

  150. NFATc1 mediates toll-like receptor-independent innate immune responses during Trypanosoma cruzi infection

    Hisako Kayama, Ritsuko Koga, Koji Atarashi, Megumi Okuyama, Taishi Kimura, Tak W. Mak, Satoshi Uematsu, Shizuo Akira, Hiroshi Takayanagi, Kenya Honda, Masahiro Yamamoto, Kiyoshi Takeda

    PLoS Pathogens　Vol. 5　No. 7　2009/07　Research paper (scientific journal)

  151. [Host immune response to Trypanosoma cruzi and its evasion mechanism].

    Masahiro Yamamoto, Kiyoshi Takeda

    Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme　Vol. 54　No. 8 Suppl　p. 1053-1058　2009/06

  152. TRAF6 is required for generation of the B-1a B cell compartment as well as T cell-dependent and-independent humoral immune responses

    Takashi Kobayashi, Tae Soo Kim, Anand Jacob, Matthew C. Walsh, Yuho Kadono, Ezequiel Fuentes-Pananá, Tomoko Yoshioka, Akihiko Yoshimura, Masahiro Yamamoto, Tsuneyasu Kaisho, Shizuo Akira, John G. Monroe, Yongwon Choi

    PLoS ONE　Vol. 4　No. 3　2009/03/09　Research paper (scientific journal)

  153. Lipid a receptor TLR4-mediated signaling pathways

    Shizuo Akira, Masahiro Yamamoto

    Advances in Experimental Medicine and Biology　Vol. 667　p. 59-68　2009　Research paper (scientific journal)

  154. Fra-1 negatively regulates lipopolysaccharide-mediated inflammatory responses

    Hideaki Morishita, Fumiji Saito, Hisako Kayama, Koji Atarashi, Hirotaka Kuwata, Masahiro Yamamoto, Kiyoshi Takeda

    International Immunology　Vol. 21　No. 4　p. 457-465　2009　Research paper (scientific journal)

  155. Involvement of linear polyubiquitylation of NEMO in NF-κB activation

    Fuminori Tokunaga, Shin Ichi Sakata, Yasushi Saeki, Yoshinori Satomi, Takayoshi Kirisako, Kiyoko Kamei, Tomoko Nakagawa, Michiko Kato, Shigeo Murata, Shoji Yamaoka, Masahiro Yamamoto, Shizuo Akira, Toshifumi Takao, Keiji Tanaka, Kazuhiro Iwai

    Nature Cell Biology　Vol. 11　No. 2　p. 123-132　2009　Research paper (scientific journal)

  156. Lipocalin 2-dependent inhibition of mycobacterial growth in alveolar epithelium

    Hiroyuki Saiga, Junichi Nishimura, Hirotaka Kuwata, Megumi Okuyama, Sohkichi Matsumoto, Shintaro Sato, Makoto Matsumoto, Shizuo Akira, Yasunobu Yoshikai, Kenya Honda, Masahiro Yamamoto, Kiyoshi Takeda

    Journal of Immunology　Vol. 181　No. 12　p. 8521-8527　2008/12/15　Research paper (scientific journal)

  157. Gene-specific requirement of a nuclear protein, IκB-ζ, for promoter association of inflammatory transcription regulators

    Soh Yamazaki, Susumu Matsuo, Tatsushi Muta, Masahiro Yamamoto, Shizuo Akira, Koichiro Takeshige

    Journal of Biological Chemistry　Vol. 283　No. 47　p. 32404-32411　2008/11/21　Research paper (scientific journal)

  158. ATP drives lamina propria T<inf>H</inf>17 cell differentiation

    Koji Atarashi, Junichi Nishimura, Tatsuichiro Shima, Yoshinori Umesaki, Masahiro Yamamoto, Masaharu Onoue, Hideo Yagita, Naoto Ishii, Richard Evans, Kenya Honda, Kiyoshi Takeda

    Nature　Vol. 455　No. 7214　p. 808-812　2008/10/09　Research paper (scientific journal)

  159. Noncanonical E2 variant-independent function of UBC13 in promoting checkpoint protein assembly

    Michael S.Y. Huen, Jun Huang, Jingsong Yuan, Masahiro Yamamoto, Shizuo Akira, Carolyn Ashley, Wei Xiao, Junjie Chen

    Molecular and Cellular Biology　Vol. 28　No. 19　p. 6104-6112　2008/10　Research paper (scientific journal)

  160. Stat6-independent tissue inflammation occurs selectively on the ocular surface and perioral skin of IκBζ-/- mice

    Mayumi Ueta, Junji Hamuro, Eiichiro Ueda, Norito Katoh, Masahiro Yamamoto, Kiyoshi Takeda, Shizuo Akira, Shigeru Kinoshita

    Investigative Ophthalmology and Visual Science　Vol. 49　No. 8　p. 3387-3394　2008/08　Research paper (scientific journal)

  161. Role of nuclear IκB proteins in the regulation of host immune responses

    Masahiro Yamamoto, Kiyoshi Takeda

    Journal of Infection and Chemotherapy　Vol. 14　No. 4　p. 265-269　2008/08

  162. Virulent Salmonella enterica infections can be exacerbated by concomitant infection of the host with a live attenuated S. enterica vaccine via Toll-like receptor 4-dependent interleukin-10 production with the involvement of both TRIF and MyD88

    Gemma L. Foster, Tom A. Barr, Andrew J. Grant, Trevelyan J. McKinley, Clare E. Bryant, Andrew MacDonald, David Gray, Masahiro Yamamoto, Shizuo Akira, Duncan J. Maskell, Pietro Mastroeni

    Immunology　Vol. 124　No. 4　p. 469-479　2008/08　Research paper (scientific journal)

  163. Class-specific regulation of pro-inflammatory genes by MyD88 pathways and IκBζ

    Hisako Kayama, Vladimir R. Ramirez-Carrozzi, Masahiro Yamamoto, Taketoshi Mizutani, Hirotaka Kuwata, Hideo Iba, Makoto Matsumoto, Kenya Honda, Stephen T. Smale, Kiyoshi Takeda

    Journal of Biological Chemistry　Vol. 283　No. 18　p. 12468-12477　2008/05/02　Research paper (scientific journal)

  164. Potent antimycobacterial activity of mouse secretory leukocyte protease inhibitor

    Junichi Nishimura, Hiroyuki Saiga, Shintaro Sato, Megumi Okuyama, Hisako Kayama, Hirotaka Kuwata, Sohkichi Matsumoto, Toshirou Nishida, Yoshiki Sawa, Shizuo Akira, Yasunobu Yoshikai, Masahiro Yamamoto, Kiyoshi Takeda

    Journal of Immunology　Vol. 180　No. 6　p. 4032-4039　2008/03/15　Research paper (scientific journal)

  165. Assessing the response of cells to TLR stimulation

    Kiyoshi Takeda, Masahiro Yamamoto, Kenya Honda

    Signaling by Toll-Like Receptors　p. 1-21　2008/01/01　Part of collection (book)

  166. The human T-cell leukemia virus type 1 tax oncoprotein requires the ubiquitin-conjugating enzyme Ubc13 for NF-κB activation

    Noula Shembade, Nicole S. Harhaj, Masahiro Yamamoto, Shizuo Akira, Edward W. Harhaj

    Journal of Virology　Vol. 81　No. 24　p. 13735-13742　2007/12　Research paper (scientific journal)

  167. FADD negatively regulates lipopolysaccharide signaling by impairing interleukin-1 receptor-associated kinase 1-MyD88 interaction

    Rachel Zhande, Shauna M. Dauphinee, James A. Thomas, Masahiro Yamamoto, Shizuo Akira, Aly Karsan

    Molecular and Cellular Biology　Vol. 27　No. 21　p. 7394-7404　2007/11　Research paper (scientific journal)

  168. The C/EBPβ isoform 34-kDa LAP is responsible for NF-IL-6-mediated gene induction in activated macrophages, but is not essential for intracellular bacteria killing

    Satoshi Uematsu, Tsuneyasu Kaisho, Takashi Tanaka, Makoto Matsumoto, Megumi Yamakami, Hiroko Omori, Masahiro Yamamoto, Tamotsu Yoshimori, Shizuo Akira

    Journal of Immunology　Vol. 179　No. 8　p. 5378-5386　2007/10/15　Research paper (scientific journal)

  169. Salmonella-induced SipB-independent cell death requires Toll-like receptor-4 signalling via the adapter proteins Tram and Trif

    Pamela Cook, Sabine Tötemeyer, Catherine Stevenson, Katherine A. Fitzgerald, Masahiro Yamamoto, Shizuo Akira, Duncan J. Maskell, Clare E. Bryant

    Immunology　Vol. 122　No. 2　p. 222-229　2007/10　Research paper (scientific journal)

  170. Role for MyD88-independent, TRIF pathway in lipid A/TLR4-induced endotoxin tolerance

    Subhra K. Biswas, Pradeep Bist, Manprit Kaur Dhillon, Tasneem Kajiji, Carlos Del Fresno, Masahiro Yamamoto, Eduardo Lopez-Collazo, Shizuo Akira, Vinay Tergaonkar

    Journal of Immunology　Vol. 179　No. 6　p. 4083-4092　2007/09/15　Research paper (scientific journal)

  171. Essential role of IRAK-4 protein and its kinase activity in Toll-like receptor-mediated immune responses but not in TCR signaling

    Tatsukata Kawagoe, Shintaro Sato, Andreas Jung, Masahiro Yamamoto, Kosuke Matsui, Hiroki Kato, Satoshi Uematsu, Osamu Takeuchi, Shizuo Akira

    Journal of Experimental Medicine　Vol. 204　No. 5　p. 1013-1024　2007/05　Research paper (scientific journal)

  172. Toll/IL-1 receptor domain-containing adaptor inducing IFN-β (TRIF)-mediated signaling contributes to innate immune responses in the lung during Escherichia coli pneumonia

    Samithamby Jeyaseelan, Scott K. Young, Michael B. Fessler, Yuhong Liu, Kenneth C. Malcolm, Masahiro Yamamoto, Shizuo Akira, G. Scott Worthen

    Journal of Immunology　Vol. 178　No. 5　p. 3153-3160　2007/03/01　Research paper (scientific journal)

  173. A role of Toll-IL-1 receptor domain-containing adaptor-inducing IFN-β in the host response to Pseudomonas aeruginosa lung infection in mice

    Melanie R. Power, Bo Li, Masahiro Yamamoto, Shizuo Akira, Tong Jun Lin

    Journal of Immunology　Vol. 178　No. 5　p. 3170-3176　2007/03/01　Research paper (scientific journal)

  174. NF-κB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1

    Sinead M. Miggin, Eva Pålsson-McDermott, Aisling Dunne, Caroline Jefferies, Emmanuel Pinteaux, Kathy Banahan, Caroline Murphy, Paul Moynagh, Masahiro Yamamoto, Shizuo Akira, Nancy Rothwell, Douglas Golenbock, Katherine A. Fitzgerald, Luke A.J. O'Neill

    Proceedings of the National Academy of Sciences of the United States of America　Vol. 104　No. 9　p. 3372-3377　2007/02/27　Research paper (scientific journal)

  175. Pathological role of Toll-like receptor signaling in cerebral malaria

    Cevayir Coban, Satoshi Uematsu, Nobuko Arisue, Shintaro Sato, Masahiro Yamamoto, Taro Kawai, Osamu Takeuchi, Hajime Hisaeda, Toshihiro Horii, Shizuo Akira

    International Immunology　Vol. 19　No. 1　p. 67-79　2007/01　Research paper (scientific journal)

  176. VP1686, a Vibrio type III secretion protein, induces Toll-like receptor-independent apoptosis in macrophage through NF-κB inhibition

    Rabindra N. Bhattacharjee, Kwon Sam Park, Yutaro Kumagai, Kazuhisa Okada, Masahiro Yamamoto, Satoshi Uematsu, Kosuke Matsui, Himanshu Kumar, Taro Kawai, Tetsuya Iida, Takeshi Honda, Osamu Takeuchi, Shizuo Akira

    Journal of Biological Chemistry　Vol. 281　No. 48　p. 36897-36904　2006/12/01　Research paper (scientific journal)

  177. TLR-dependent induction of IFN-β mediates host defense against Trypanosoma cruzi

    Ritsuko Koga, Shinjiro Hamano, Hirotaka Kuwata, Koji Atarashi, Masahiro Ogawa, Hajime Hisaeda, Masahiro Yamamoto, Shizuo Akira, Kunisuke Himeno, Makoto Matsumoto, Kiyoshi Takeda

    Journal of Immunology　Vol. 177　No. 10　p. 7059-7066　2006/11/15　Research paper (scientific journal)

  178. The myeloid differentiation factor 88 is dispensable for the development of a delayed host response to Pseudomonas aeruginosa lung infection in mice

    M. R. Power, J. S. Marshall, M. Yamamoto, S. Akira, T. J. Lin

    Clinical and Experimental Immunology　Vol. 146　No. 2　p. 323-329　2006/11　Research paper (scientific journal)

  179. TAK1 is indispensable for development of T cells and prevention of colitis by the generation of regulatory T cells

    Shintaro Sato, Hideki Sanjo, Tohru Tsujimura, Jun Ninomiya-Tsuji, Masahiro Yamamoto, Taro Kawai, Osamu Takeuchi, Shizuo Akira

    International Immunology　Vol. 18　No. 10　p. 1405-1411　2006/10　Research paper (scientific journal)

  180. Detection of pathogenic intestinal bacteria by Toll-like receptor 5 on intestinal CD11c+ lamina propria cells

    Satoshi Uematsu, Myoung Ho Jang, Nicolas Chevrier, Zijin Guo, Yutaro Kumagai, Masahiro Yamamoto, Hiroki Kato, Nagako Sougawa, Hidenori Matsui, Hirotaka Kuwata, Hiroaki Hemmi, Cevayir Coban, Taro Kawai, Ken J. Ishii, Osamu Takeuchi, Masayuki Miyasaka, Kiyoshi Takeda, Shizuo Akira

    Nature Immunology　Vol. 7　No. 8　p. 868-874　2006/08　Research paper (scientific journal)

  181. Essential role of IPS-1 in innate immune responses against RNA viruses

    Himanshu Kumar, Taro Kawai, Hiroki Kato, Shintaro Sato, Ken Takahashi, Cevayir Coban, Masahiro Yamamoto, Satoshi Uematsu, Ken J. Ishii, Osamu Takeuchi, Shizuo Akira

    Journal of Experimental Medicine　Vol. 203　No. 7　p. 1795-1803　2006/07/10　Research paper (scientific journal)

  182. Toll/IL-1R domain-containing adaptor protein (TIRAP) is a critical mediator of antibacterial defense in the lung against Klebsiella pneumoniae but not Pseudomonas aeruginosa

    Samithamby Jeyaseelan, Scott K. Young, Masahiro Yamamoto, Patrick G. Arndt, Shizuo Akira, Jay K. Kolls, G. Scott Worthen

    Journal of Immunology　Vol. 177　No. 1　p. 538-547　2006/07/01　Research paper (scientific journal)

  183. Negative regulation of interferon-regulatory factor 3-dependent innate antiviral response by the prolyl isomerase Pin1

    Tatsuya Saitoh, Adrian Tun-Kyi, Akihide Ryo, Masahiro Yamamoto, Greg Finn, Takashi Fujita, Shizuo Akira, Naoki Yamamoto, Kun Ping Lu, Shoji Yamaoka

    Nature Immunology　Vol. 7　No. 6　p. 598-605　2006/06　Research paper (scientific journal)

  184. Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses

    Hiroki Kato, Osamu Takeuchi, Shintaro Sato, Mitsutoshi Yoneyama, Masahiro Yamamoto, Kosuke Matsui, Satoshi Uematsu, Andreas Jung, Taro Kawai, Ken J. Ishii, Osamu Yamaguchi, Kinya Otsu, Tohru Tsujimura, Chang Sung Koh, Caetano Reis E Sousa, Yoshiharu Matsuura, Takashi Fujita, Shizuo Akira

    Nature　Vol. 441　No. 1　p. 101-105　2006/05/04　Research paper (scientific journal)

  185. "Endogenous adjuvant" activity of the RNA components of lupus auto antigens Sm/RNP and Ro 60

    Kindra M. Kelly, Haoyang Zhuang, Dina C. Nacionales, Philip O. Scumpia, Robert Lyons, Jun Akaogi, Pui Lee, Bryan Williams, Masahiro Yamamoto, Shizuo Akira, Minoru Satoh, Westley H. Reeves

    Arthritis and Rheumatism　Vol. 54　No. 5　p. 1557-1567　2006/05　Research paper (scientific journal)

  186. Erratum: A toll-like receptor-independent antiviral response induced by double-stranded B-form DNA (Nature Immunology (2005) vol. 7 (40-48))

    Ken J. Ishii, Cevayir Coban, Hiroki Kato, Ken Takahashi, Yuichi Torii, Fumihiko Takeshita, Holger Ludwig, Gerd Sutter, Koichi Suzuki, Hiroaki Hemmi, Shintaro Sato, Masahiro Yamamoto, Satoshi Uematsu, Taro Kawai, Osamu Takeuchi, Shizuo Akira

    Nature Immunology　Vol. 7　No. 4　2006/04　Research paper (scientific journal)

  187. The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction

    Daniel C. Rowe, Anne F. McGettrick, Eicke Latz, Brian G. Monks, Nicholas J. Gay, Masahiro Yamamoto, Shizuo Akira, Luke A. O'Neill, Katherine A. Fitzgerald, Douglas T. Golenbock

    Proceedings of the National Academy of Sciences of the United States of America　Vol. 103　No. 16　p. 6299-6304　2006/04　Research paper (scientific journal)

  188. Mechanism of pathogen-specific TLR4 activation in the mucosa: Fimbriae, recognition receptors and adaptor protein selection

    Hans Fischer, Masahiro Yamamoto, Shizuo Akira, Bruce Beutler, Catharina Svanborg

    European Journal of Immunology　Vol. 36　No. 2　p. 267-277　2006/02　Research paper (scientific journal)

  189. A toll-like receptor-independent antiviral response induced by double-stranded B-form DNA

    Ken J. Ishii, Cevayir Coban, Hiroki Kato, Ken Takahashi, Yuichi Torii, Fumihiko Takeshita, Holger Ludwig, Gerd Sutter, Koichi Suzuki, Hiroaki Hemmi, Shintaro Sato, Masahiro Yamamoto, Satoshi Uematsu, Taro Kawai, Osamu Takeuchi, Shizuo Akira

    Nature Immunology　Vol. 7　No. 1　p. 40-48　2006/01　Research paper (scientific journal)

  190. BS69, a specific adaptor in the latent membrane protein 1-mediated c-Jun N-terminal kinase pathway

    Jun Wan, Wei Zhang, Liming Wu, Ting Bai, Mingjie Zhang, Kwok Wai Lo, Yiu Ioon Chui, Yan Cui, Qian Tao, Masahiro Yamamoto, Shizuo Akira, Zhenguo Wu

    Molecular and Cellular Biology　Vol. 26　No. 2　p. 448-456　2006/01　Research paper (scientific journal)

  191. Toll-IL-1 receptor domain-containing adaptor protein is critical for early lung immune responses against Escherichia coli lipopolysaccharide and viable Escherichia coli

    Samithamby Jeyaseelan, Rizwan Manzer, Scott K. Young, Masahiro Yamamoto, Shizuo Akira, Robert J. Mason, G. Scott Worthen

    Journal of Immunology　Vol. 175　No. 11　p. 7484-7495　2005/12/01　Research paper (scientific journal)

  192. Essential function for the kinase TAK1 in innate and adaptive immune responses

    Shintaro Sato, Hideki Sanjo, Kiyoshi Takeda, Jun Ninomiya-Tsuji, Masahiro Yamamoto, Taro Kawai, Kunihiro Matsumoto, Osamu Takeuchi, Shizuo Akira

    Nature Immunology　Vol. 6　No. 11　p. 1087-1095　2005/11　Research paper (scientific journal)

  193. The RNA helicase Lgp2 inhibits TLR-independent sensing of viral replication by retinoic acid-inducible gene-I

    Simon Rothenfusser, Nadege Goutagny, Gary DiPerna, Mei Gong, Brian G. Monks, Annett Schoenemeyer, Masahiro Yamamoto, Shizuo Akira, Katherine A. Fitzgerald

    Journal of Immunology　Vol. 175　No. 8　p. 5260-5268　2005/10/15　Research paper (scientific journal)

  194. Priming effect of lipopolysaccharide on acetyl-coenzyme A: Lyso-platelet-activating factor acetyltransferase is MyD88 and TRIF independent

    Hideo Shindou, Satoshi Ishii, Masahiro Yamamoto, Kiyoshi Takeda, Shizuo Akira, Takao Shimizu

    Journal of Immunology　Vol. 175　No. 2　p. 1177-1183　2005/07/15　Research paper (scientific journal)

  195. Cell type-specific involvement of RIG-I in antiviral response

    Hiroki Kato, Shintaro Sato, Mitsutoshi Yoneyama, Masahiro Yamamoto, Satoshi Uematsu, Kosuke Matsui, Tohru Tsujimura, Kiyoshi Takeda, Takashi Fujita, Osamu Takeuchi, Shizuo Akira

    Immunity　Vol. 23　No. 1　p. 19-28　2005/07　Research paper (scientific journal)

  196. Induction of CXCL5 during inflammation in the rodent lung involves activation of alveolar epithelium

    Samithamby Jeyaseelan, Rizwan Manzer, Scott K. Young, Masahiro Yamamoto, Shizuo Akira, Robert J. Mason, G. Scott Worthen

    American Journal of Respiratory Cell and Molecular Biology　Vol. 32　No. 6　p. 531-539　2005/06　Research paper (scientific journal)

  197. Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-α induction

    Satoshi Uematsu, Shintaro Sato, Masahiro Yamamoto, Tomonori Hirotani, Hiroki Kato, Fumihiko Takeshita, Michiyuki Matsuda, Cevayir Coban, Ken J. Ishii, Taro Kawai, Osamu Takeuchi, Shizuo Akira

    Journal of Experimental Medicine　Vol. 201　No. 6　p. 915-923　2005/03/21　Research paper (scientific journal)

  198. The nuclear IκB protein IκBNS selectively inhibits lipopolysaccharide-induced IL-6 production in macrophages of the colonic lamina propria

    Tomonori Hirotani, Pui Y. Lee, Hirotaka Kuwata, Masahiro Yamamoto, Makoto Matsumoto, Ichiro Kawase, Shizuo Akira, Kiyoshi Takeda

    Journal of Immunology　Vol. 174　No. 6　p. 3650-3657　2005/03/15　Research paper (scientific journal)

  199. Regulation of lipopolysaccharide-inducible genes by MyD88 and Toll/IL-1 domain containing adaptor inducing IFN-β

    Tomonori Hirotani, Masahiro Yamamoto, Yutaro Kumagai, Satoshi Uematsu, Ichiro Kawase, Osamu Takeuchi, Shizuo Akira

    Biochemical and Biophysical Research Communications　Vol. 328　No. 2　p. 383-392　2005/03/11　Research paper (scientific journal)

  200. A20 is a negative regulator of IFN regulatory factor 3 signaling

    Tatsuya Saitoh, Masahiro Yamamoto, Makoto Miyagishi, Kazunari Taira, Makoto Nakanishi, Takashi Fujita, Shizuo Akira, Naoki Yamamoto, Shoji Yamaoka

    Journal of Immunology　Vol. 174　No. 3　p. 1507-1512　2005/02/01　Research paper (scientific journal)

  201. Spontaneous ocular surface inflammation and goblet cell disappearance in IκBζ gene-disrupted mice

    Mayumi Ueta, Junji Hamuro, Masahiro Yamamoto, Kazuhiro Kaseda, Shizuo Akira, Shigeru Kinoshita

    Investigative Ophthalmology and Visual Science　Vol. 46　No. 2　p. 579-588　2005/02　Research paper (scientific journal)

  202. Roles of Stat3 and ERK in G-CSF signaling.

    Kenjirou Kamezaki, Kazuya Shimoda, Akihiko Numata, Takashi Haro, Haruko Kakumitsu, Masumi Yoshie, Masahiro Yamamoto, Kiyoshi Takeda, Tadashi Matsuda, Shizuo Akira, Katsuhiro Ogawa, Mine Harada

    Stem cells (Dayton, Ohio)　Vol. 23　No. 2　p. 252-63　2005/02　Research paper (scientific journal)

  203. Toll-like receptor 9 mediates innate immune activation by the malaria pigment hemozoin

    Cevayir Coban, Ken J. Ishii, Taro Kawai, Hiroaki Hemmi, Shintaro Sato, Satoshi Uematsu, Masahiro Yamamoto, Osamu Takeuchi, Sawako Itagaki, Nirbhay Kumar, Toshihiro Horii, Shizuo Akira

    Journal of Experimental Medicine　Vol. 201　No. 1　p. 19-25　2005/01/03　Research paper (scientific journal)

  204. Mechanisms of innate immune responses mediated by Toll-like receptors

    Masahiro Yamamoto, Shizuo Akira

    Clinical and Applied Immunology Reviews　Vol. 5　No. 3　p. 167-183　2005　Research paper (scientific journal)

  205. TIR domain-containing adaptors regulate TLR signaling pathways

    Masahiro Yamamoto, Shizuo Akira

    Advances in Experimental Medicine and Biology　Vol. 560　p. 1-9　2005　Research paper (international conference proceedings)

  206. IFN regulatory factor 3-dependent induction of type I IFNs by intracellular bacteria is mediated by a TLR- and Nod2-independent mechanism

    Silvia Stockinger, Benjamin Reutterer, Barbara Schaljo, Carola Schellack, Sylvia Brunner, Tilo Materna, Masahiro Yamamoto, Shizuo Akira, Tadatsugu Taniguchi, Peter J. Murray, Mathias Müller, Thomas Decker

    Journal of Immunology　Vol. 173　No. 12　p. 7416-7425　2004/12/15　Research paper (scientific journal)

  207. TIR domain--containing adaptors regulate TLR-mediated signaling pathways

    Masahiro Yamamoto, Shizuo Akira

    Nippon rinsho. Japanese journal of clinical medicine　Vol. 62　No. 12　p. 2197-2203　2004/12

  208. ASC is essential for LPS-induced activation of procaspase-1 independently of TLR-associated signal adaptor molecules

    Masatatsu Yamamoto, Katsuyuki Yaginuma, Hiroko Tsutsui, Junji Sagara, Xin Guan, Ekihiro Seki, Koubun Yasuda, Masahiro Yamamoto, Shizuo Akira, Kenji Nakanishi, Tetsuo Noda, Shun'ichiro Taniguchi

    Genes to Cells　Vol. 9　No. 11　p. 1055-1067　2004/11　Research paper (scientific journal)

  209. Activation of TBK1 and IKKε kinases by vesicular stomatitis virus infection and the role of viral ribonucleoprotein in the development of interferon antiviral immunity

    Benjamin R. TenOever, Sonia Sharma, Wen Zou, Qiang Sun, Nathalie Grandvaux, Ilkka Julkunen, Hiroaki Hemmi, M. Yamamoto, Shizuo Akira, Wen Chen Yeh, Rongtuan Lin, John Hiscott

    Journal of Virology　Vol. 78　No. 19　p. 10636-10649　2004/10　Research paper (scientific journal)

  210. Interferon-α induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6

    Taro Kawai, Shintaro Sato, Ken J. Ishii, Cevayir Coban, Hiroaki Hemmi, Masahiro Yamamoto, Kenta Terai, Michiyuki Matsuda, Jun Ichiro Inoue, Satoshi Uematsu, Osamu Takeuchi, Shizuo Akira

    Nature Immunology　Vol. 5　No. 10　p. 1061-1068　2004/10　Research paper (scientific journal)

  211. MyD88 but not TRIF is essential for osteoclastogenesis induced by lipopolysaccharide, diacyl lipopeptide, and IL-1α

    Nobuaki Sato, Naoyuki Takahashi, Koji Suda, Midori Nakamura, Mariko Yamaki, Tadashi Ninomiya, Yasuhiro Kobayashi, Haruhiko Takada, Kenichiro Shibata, Masahiro Yamamoto, Kiyoshi Takeda, Shizuo Akira, Toshihide Noguchi, Nobuyuki Udagawa

    Journal of Experimental Medicine　Vol. 200　No. 5　p. 601-611　2004/09/06　Research paper (scientific journal)

  212. The roles of two IκB kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infection

    Hiroaki Hemmi, Osamu Takeuchi, Shintaro Sato, Masahiro Yamamoto, Tsuneyasu Kaisho, Hideki Sanjo, Taro Kawai, Katsuaki Hoshino, Kiyoshi Takeda, Shizuo Akira

    Journal of Experimental Medicine　Vol. 199　No. 12　p. 1641-1650　2004/06/21　Research paper (scientific journal)

  213. TIR domain-containing adaptors define the specificity of TLR signaling

    Masahiro Yamamoto, Kiyoshi Takeda, Shizuo Akira

    Molecular Immunology　Vol. 40　No. 12　p. 861-868　2004/02　Research paper (scientific journal)

  214. IL-10-inducible Bcl-3 negatively regulates LPS-induced TNF-α production in macrophages

    Hirotaka Kuwata, Yasuyuki Watanabe, Hiroyuki Miyoshi, Masahiro Yamamoto, Tsuneyasu Kaisho, Kiyoshi Takeda, Shizuo Akira

    Blood　Vol. 102　No. 12　p. 4123-4129　2003/12/01　Research paper (scientific journal)

  215. Toll/IL-1 receptor domain-containing adaptor inducing IFN-β (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-κB and IFN-regulatory factor-3, in the toll-like receptor signaling

    Shintaro Sato, Masanaka Sugiyama, Masahiro Yamamoto, Yasuyuki Watanabe, Taro Kawai, Kiyoshi Takeda, Shizuo Akira

    Journal of Immunology　Vol. 171　No. 8　p. 4304-4310　2003/10/15　Research paper (scientific journal)

  216. Role of adapters in Toll-like receptor signalling

    S. Akira, M. Yamamoto, K. Takeda

    Biochemical Society Transactions　Vol. 31　No. 3　p. 637-642　2003/06　Research paper (international conference proceedings)

Misc. 23

  1. Gate-16 is required for LC3-independent antimicrobial host defense through cytosolic distribution of interferon-inducible GTPases

    Miwa Sasai, Masahiro Yamamoto

    CYTOKINE　Vol. 100　p. 29-29　2017/12　Research paper, summary (international conference)

  2. Mechanisms of Toxoplasma gondii virulence by regulating host immunity

    Vol. 64　No. 6　p. 533-539　2015/12

    Publisher: 科学評論社

  3. Regulation of Toxoplasmosis by cell-autonomous innate immunity

    Vol. 64　No. 4　p. 410-415　2015/10

    Publisher: 科学評論社

  4. RabGDIαはインターフェロン-ガンマ誘導性GTPaseによる細胞内寄生性病原体の排除を制御する

    大嶋 淳, 野杁 由一郎, 山本 雅裕, 林 美加子

    特定非営利活動法人日本歯科保存学会学術大会プログラムおよび講演抄録集　Vol. 142回　p. 70-70　2015/06

    Publisher: (NPO)日本歯科保存学会

  5. インターフェロン誘導性遺伝子群GBPの抗トキソプラズマ自然免疫における役割の解明

    山本雅裕, 山本雅裕, 大嶋淳, 大嶋淳, 馬知秀, 馬知秀, 神山長慶, 竹田潔, 竹田潔

    日本寄生虫学会大会プログラム・抄録集　Vol. 82nd　2013

  6. トキソプラズマに対するインターフェロンγ誘導性遺伝子群GBPの役割について

    山本雅裕, 大嶋淳, 馬知秀, 神山長慶, 竹田潔

    日本寄生虫学会東日本支部大会プログラム・講演要旨　Vol. 72nd　2012

  7. Negative regulation of host innate immune responses by a Toxoplasma kinase ROP16

    Clinical immunology & allergology　Vol. 55　No. 1　p. 54-60　2011/01

    Publisher: 科学評論社

  8. Conditional ablation of Ubc13 in keratinocytes induces abnormal differentiation, decreased proliferation, and apoptosis

    Koji Sayama, Yuji Shirakata, Yasushi Hanakawa, Satoshi Hirakawa, Xiuju Dai, Masahiro Yamamoto, Shizuo Akira, Koji Hashimoto

    JOURNAL OF DERMATOLOGY　Vol. 37　p. 33-33　2010/09　Research paper, summary (international conference)

  9. Regulation of T cell receptor signaling by ubiquitin ligases

    Clinical immunology & allergology　Vol. 48　No. 4　p. 421-427　2007/10

    Publisher: 科学評論社

  10. Regulation of endotoxin tolerance by myeloid differentiation factor 88-independent signaling and its downstream cytokine, interferon beta

    Subhra K. Biswas, Pradeep Bist, Manprit Dhillon, Tasneem Kajiji, Carlos Del Fresno, Masahiro Yamamoto, Eduardo Lopez-Collazo, Shizuo Akira, Vinay Tergaonkar

    CYTOKINE　Vol. 39　No. 1　p. 3-3　2007/07　Research paper, summary (international conference)

  11. Effects of combined TLR stimulation on interleukin-27 mRNA expression in human monocyte-derived dendritic cells

    Sinead M. Migpin, Eva Palsson-McDermott, Aisling Dunne, Caroline Jefferies, Emmanuel Pinteaux, Kathy Banahan, Caroline Murphy, Paul Moynagh, Masahiro Yamamoto, Shizuo Akira, Nancy Rothwell, Douglas Golenbock, Katherine A. Fitzgerald, Luke A. J. O'Neill

    CYTOKINE　Vol. 39　No. 1　p. 27-28　2007/07　Research paper, summary (international conference)

  12. IRAK-1はTLR7とTLR9を解するIFN-α産生に必須の役割を果たす

    植松智, 佐藤慎太郎, 山本雅裕, 加藤博己, 石井健, 河合太郎, 竹内理, 竹内理, 審良静男, 審良静男

    日本免疫学会総会・学術集会記録　Vol. 35　2005

  13. The roles of stat3 and ERK in G-CSF signaling.

    K Kamezaki, K Shimoda, A Numata, M Yoshie, M Yamamoto, K Takeda, T Matsuda, S Akira, K Ogawa, M Harada

    BLOOD　Vol. 104　No. 11　p. 597A-597A　2004/11　Research paper, summary (international conference)

  14. 2本鎖RNAにより活性化されるTLR3依存性,非依存性経路の機能的相違

    改正 恒康, 邊見 弘明, 山本 雅裕, 竹内 理, 星野 克明, 審良 静男

    日本免疫学会総会・学術集会記録　Vol. 34　p. 200-200　2004/11

    Publisher: (NPO)日本免疫学会

  15. アダプター分子によるMyD88依存的経路とMyD88非依存的経路の制御--TIRAPとTRIFの役割 (免疫2004) -- (自然免疫)

    山本 雅裕, 竹田 潔, 審良 静男

    免疫　Vol. 2004　p. 201-209　2004

    Publisher: 中山書店

  16. TLRの病原体認識特異性とシグナル伝達経路機構

    山本雅裕

    医学のあゆみ 別冊自然免疫と疾患　2004

  17. RIG-I欠損マウスの作成および解析

    加藤博己, 佐藤慎太郎, 山本雅裕, 松井孝介, 植松智, 竹田潔, 竹内理, 審良静男

    日本免疫学会総会・学術集会記録　Vol. 34　2004

  18. Plasmacytoid DCにおけるToll-like receptor 9によるtype Iインターフェロンの誘導機構

    植松智, 佐藤慎太郎, 山本雅裕, 加藤博己, 石井健, 河合太郎, 竹内理, 審良静男

    日本免疫学会総会・学術集会記録　Vol. 34　2004

  19. Toll様受容体を介したI型IFN産生誘導のメカニズム

    河合太郎, 佐藤慎太郎, 石井健, COBAN C, 辺見弘明, 山本雅裕, 植松智, 竹内理, 審良静男

    日本免疫学会総会・学術集会記録　Vol. 34　2004

  20. TRIFはTLRのMyD88非依存的経路を担うアダプター分子である

    山本 雅裕, 佐藤 慎太郎, 辺見 弘明, 改正 恒康, 星野 克明, 竹田 潔, 審良 静男

    日本免疫学会総会・学術集会記録　Vol. 33　p. 122-122　2003/11

    Publisher: (NPO)日本免疫学会

  21. TBK1/NAK/T2KはLPSによるIFN-inducible geneの発現に関与する

    邊見 弘明, 佐藤 慎太郎, 山本 雅裕, 改正 恒康, 河合 太郎, 星野 克明, 竹田 潔, 審良 静男

    日本免疫学会総会・学術集会記録　Vol. 33　p. 123-123　2003/11

    Publisher: (NPO)日本免疫学会

  22. Toll-like receptor 研究の最前線

    山本 雅裕, 審良 静男

    臨床と微生物 = Clinical microbiology　Vol. 30　No. 3　p. 249-253　2003/05/25

  23. TIRAP/MalはTLR4シグナルだけでなく,TLR2シグナルにも関わっている

    山本雅裕, 佐藤慎太郎, 辺見弘明, 山条秀樹, 植松智, 改正恒康, 星野克明, 竹田潔, 審良静男

    日本免疫学会総会・学術集会記録　Vol. 32　2002

Presentations 73

  1. The novel VeDTR mouse system reveals roles of immune cells in anti-tumor immunity

    Masahiro Yamamoto

    The 2nd Doherty Institute & partners – IFReC Immunology Symposium　2024/02

  2. Recognition of PLAMP by cell-autonomous immunity is important for anti-Toxoplasma host defense

    山本 雅裕

    第20回あわじ感染と免疫国際フォーラム　2022/09

  3. Role of PLCbeta4 in CD8+ T cell signaling

    2021/12

  4. 肝臓期マラリア原虫の分化を制御する宿主因子の同定

    山本 雅裕

    第72回日本細菌学会九州支部総会 第56回日本ウイルス学会九州支部総会　2019/09

  5. Role of CXCR4 in liver stage Plasmodium development

    Masahiro Yamamoto

    The 18th Awaji International Forum on Infection and Immunity　2019/09

  6. 常在グラム陰性細菌に対するCaspase-11インフラマソームの制御機構

    山本 雅裕

    第84回日本インターフェロン・サイトカイン学会学術集会　2019/08

  7. 肝臓期マラリアの分化に関与する宿主因子の同定

    山本 雅裕

    第27回分子寄生虫学ワークショップ/第17回分子寄生虫・マラリア研究フォーラム合同大会　2019/08

  8. Molecular basis of Toxoplasma PV membrane targeting by Irgb6

    Masahiro Yamamoto

    The XVth International Toxoplasma Congress　2019/06

  9. Cell-intrinsic host defense and microbial counterdefense

    Masahiro Yamamoto

    International Molecular Immunology & Immunogenetics congress　2019/04

  10. Toxoplasma GRA15-dependent suppression of IFN-gamma-induced anti-parasitic response

    Masahiro Yamamoto

    23th Annual Woods Hole ImmunoParasitology Conference　2019/04

  11. 病原性寄生虫トキソプラズマと宿主免疫の攻防

    山本 雅裕

    第１回 日本医学会連合Rising Starリトリート　2019/03

  12. トキソプラズマの寄生虫免疫学から導かれた意外な創薬ターゲット

    山本 雅裕

    新興・再興感染症制御プロジェクト 合同シンポジウム　2019/03

  13. Targeted disruption of IFN-γ-induced IDO1-dependent anti-parasitic response in human cells by Toxoplasma effector TgIST

    Masahiro Yamamoto

    The 3rd Asian Congress of Protistology & 10th Asian Conference of Ciliate Biology & 2nd International Symposium on Biodiversity and Evolution of Protozoa　2018/11

  14. トキソプラズマの宿主免疫返り討ち戦法について

    山本雅裕

    第２６回分子寄生虫学ワークショップ/第16回分子寄生虫・マラリア研究フォーラム合同大会　2018/09

  15. Role of cell-intrinsic and innate immunity by interferon-inducible GTPases

    Masahiro Yamamoto

    The 10th Japanese-German Immunology Workshop　2018/09

  16. Host cell-intrinsic host defense and counter defenses against Toxoplasma

    Masahiro Yamamoto

    ICOPA2018 Biology and interaction of host/cell and Toxoplasma gondii infection　2018/08

  17. IFNγによる宿主免疫系におけるオートファジー関連分子群の非標準的役割

    山本雅裕

    日本インターフェロン・サイトカイン学会 シンポジウム２　2018/07

  18. 感染防御免疫系におけるATG8ファミリー分子群の役割

    山本雅裕

    千里ライフサイエンスセミナー M2 オートファジーと疾患　2018/06

  19. Essential role of ATG proteins in cell-autonomous innate immunity to vacuolar pathogens

    Masahiro Yamamoto

    15th International Conference on Innate Immunity　2018/06

  20. 肝臓機マラリア原虫の文化に重要な宿主因子の探索

    山本雅裕

    第７０回日本衛星動物学会大会　2018/05

  21. Role of Atg8 in the regulation of NLRP3 inflammasome-mediated pyroptosis

    Masahiro Yamamoto

    Australia-Japan Meeting on Cell Death　2018/05

  22. Suppression of human IFN-γ-mediated anti-parasitic cell-autonomous immunity by a Toxoplasma effector

    Masahiro Yamamoto

    Intrisic Defenses and Counterdefenses Keystone Symposia　2018/03

  23. A family member of phospholipase C is required for CD8 T cell-mediated anti-Toxoplasma host defense

    Masahiro Yamamoto

    WHIP 2018 22th Annual Woods Hole ImmunoParasitology Conference　2018/03

  24. Critical roles of GABARAPs on interferon-mediated cell-autonomous immune responses against T. gondii infection

    Miwa Sasai, Naoya Sakaguchi, Ji Su Ma, Youngae Lee, Hironori Bando, Shizuo Akira, Masahiro Yamamoto

    第46回 日本免疫学会学術集会　2017/12

  25. PLCβ plays an important role in CD8 T cell-mediated host defense against Toxoplasma gondii

    Ji Su Ma, Miwa Sasai, Youngae Lee, Naoya Sakaguchi, Hironori Bando, Masahiro Yamamoto

    第46回 日本免疫学会学術集会　2017/12

  26. Role of GABARAP subfamily in the regulation of non-canonical inflammasome activation

    Naoya Sakaguchi, Ji Su Ma, Youngae Lee, Hironori Bando, Miwa Sasai, Masahiro Yamamoto

    第46回 日本免疫学会学術集会　2017/12

  27. Immunoparasitology of Toxoplasma gondii

    Masahiro Yamamoto

    The 2nd Annual International Conference and Exhibition on Indonesian Medical Education and Research Institute(IMERI) 2017　2017/12

  28. A mechanism of interferon-γ-induced anti-Toxoplasma gondii host defense

    Masahiro Yamamoto

    The 7th International Symposium on Parasitology　2017/10

  29. The Mammalian Atg8 Gabarap Subfamily Play a Non-Redundant Key Role in IFN-γ-Inducible GTPase-Dependent Host Defense Against Vacuolar Pathogens

    Miwa Sasai, Naoya Sakaguchi, Ji SuMa, Youngae Lee, Hironori Bando, Masahiro Yamamoto

    第16回 あわじしま感染症・免疫フォーラム　2017/09

  30. Atg8ファミリーのインターフェロン誘導性自然免疫における役割について

    山本 雅裕, 笹井 美和, 坂口 直哉, 馬 知秀

    The 3rd Annual Meeting of Japanese Society of Osteoimmunology 2017 ISHIGAKI　2017/06

  31. GABARAPs are required for the LC3-Independent antimicrobial host defense through cytosolic distribution of Interferon-Inducible GTPases

    Miwa Sasai, Masahiro Yamamoto

    8th International symposium on Autophagy　2017/05

  32. GABARAPs are required for LC3s-independent anti-Toxoplasma gondii host defense through cytosolic distribution of interferon-inducible GTPases

    Masahiro Yamamoto

    Toxo-14 (The Toxoplasma gondii research community biennial meeting 2017)　2017/05

  33. Critical role of GABARAP Atg8 subfamily in IFN-γ-induced cell-autonomous immunity to Toxoplasma gondii

    Masahiro Yamamoto

    21th Annual Woods Hole ImmunoParasitology Conference　2017/04

  34. PLCβ4 plays an important role in CD8 T cell-mediated host defense against Toxoplasma gondii

    Ji Su Ma, Miwa Sasai,Youngae Lee,Hironori Bando, and Masahiro Yamamoto

    第10回 寄生虫感染免疫研究会　2017/02

  35. Essential role of Gate-16 in anti-Toxoplasma gondii immune response

    Miwa Sasai, Ji Su Ma, Youngae Lee, Hironori Bando, Masahiro Yamamoto

    第10回 寄生虫感染免疫研究会　2017/02

  36. Interferon-induced activation of cell-autonomous immunity against vacuolar pathogens

    Masahiro Yamamoto

    The 45th Annual meeting of the Japanese Society for Immunology　2016/12

  37. The Atg8 family members play a critical role in non-autophagic cell-autonomous immunity to vacuolar pathogens

    Miwa Sasai, Naoya Sakaguchi, Masahiro Yamamoto

    Keystome symposia　2016/12

  38. A mechanism for interferon-γ-induced ubiquitin decoration of Toxoplasma gondii parasitophorous vacuoles

    Youngae Lee, Miwa Sasai, Ji Su Ma, Naoya Sakaguchi, Hironori Bando, Ariel Pradipta, and Masahiro Yamamoto

    Forum Cheju18 Korea-Japan Parasitologists’Seminar　2016/10

  39. Mechanism of IFN-γ-inducible cell-autonomous immunity to intracellular pathogens

    山本 雅裕

    Awaji Yumebutai International Conference Center on Awaji Island　2016/09

  40. インターフェロンγによる細胞内寄生性病原体の排除機構

    山本 雅裕

    第81回日本インターフェロン・サイトカイン学会学術集会　2016/05

  41. ヒト細胞におけるIFNγ依存的な抗トキソプラズマ応答にはIDO2ではなくIDO1が重要な役割を果たす

    伴戸 寛徳、笹井 美和、馬 知秀、李 英愛、坂口 直哉、山本 雅裕

    第85回 日本寄生虫学会大会　2016/03

  42. オートファジーアダプター分子p62はインターフェロンγ誘導性のトキソプラズマの寄生胞抗原の提示に特異的に関与する

    山本雅裕、李栄愛、笹井美和、馬知秀、伴戸博徳、坂口直哉

    第85回 日本寄生虫学会大会　2016/03

  43. p62/Sqstm1 plays a specific role in CD8+ T cell activation by antigen-presenting cells after IFN-γ-induced disruption of the parasitophorous vacuoles of Toxoplasma gondii

    Masahiro Yamamoto, Youngae Lee

    第9回 寄生虫感染免疫研究会　2016/02

  44. FN-γ-inducible cell-autonomous immunity to intracellular pathogens

    Masahiro Yamamoto

    The 7th International Symposium of IFReC　2016/01

  45. インターフェロンγ誘導性GTPaseによるトキソプラズマ寄生胞の破壊制御機構

    山本 雅裕

    第38回日本分子生物学会年会、第88回日本生化学会大会 合同大会　2015/12

  46. p62 plays a specific role in IFN-g-induced presentation of a Toxoplasma vacuolar antigen

    Youngae Lee, Miwa Sasai, Ji Su Ma, Naoya Sakaguchi, Jun Ohshima, Hironori Bando, Tatsuya Saitoh, Shizuo Akira, and Masahiro Yamamoto

    The 44th Annual Meeting of The Japanese Society for Immunology　2015/11

  47. RabGDIα is a negative regulator of interferon-γ-inducible GTPase-dependent cell-autonomous immunity to Toxoplasma gondii

    Miwa Sasai, Jun Ohshima, Ji Su Ma, Youngae Lee, Kiyoshi Takeda, Masahiro Yamamoto

    The 44th Annual Meeting of The Japanese Society for Immunology　2015/11

  48. p62 plays a specific role in IFN-g-induced presentation of a Toxoplasma vacuolar antigen

    Youngae Lee, Miwa Sasai, Ji Su Ma, Naoya Sakaguchi, Jun Ohshima, Hironori Bando, Tatsuya Saitoh, Shizuo Akira, and Masahiro Yamamoto

    Forum Cheju17　2015/11

  49. Selective and strain-specific NFAT4 activation by the Toxoplasma gondii polymorphic dense granule protein GRA6

    Ji Su Ma, Miwa Sasai, Jun Ohshima, Youngae Lee, Hironori Bando, Kiyoshi Takeda, and Masahiro Yamamoto

    Forum Cheju17　2015/11

  50. トキソプラズマ病原性因子による免疫ハイジャック機構

    Yamamoto M

    第158回日本獣医学会学術集会 シンポジウム　2015/09

  51. 宿主免疫系によるトキソプラズマ原虫の排除機構とその破綻の分子機構

    Yamamoto M

    第27回 日本比較免疫学会学術集会 シンポジウム　2015/08

  52. Positive and Negative Regulation of IFN-γ-inducible GTPase-dependent cell-autonomous immunity to Toxoplasma gondii

    Yamamoto M

    RIKEN IMS-JSI International Symposium on Immunology 2015　2015/06

  53. 肝臓期マラリア原虫を標的とした新規抗マラリア薬の開発

    伴戸 寛徳, 笹井 美和, 馬 知秀, 大嶋 淳, 李 英愛, 山本 雅裕

    第84回日本寄生虫学会大会　2015/03

  54. トキソプラズマ原虫の多型濃縮顆粒タンパク質GRA6による選択的NFAT4の活性化について

    馬 知秀, 笹井 美和, 大嶋 淳, 李 英愛, 伴戸 寛徳, 竹田 潔, 山本 雅裕

    第84回日本寄生虫学会大会　2015/03

  55. トキソプラズマ病原性因子GRA6による宿主免疫乗っ取り機構

    山本 雅裕

    感染症国際研究センター/共同研究拠点 若手ジョイントシンポジウム　2015/02

  56. RabGDIα is a negative regulator of interferon-γ-inducible GTPase-dependent cell-autonomous host defense against Toxoplasma gondii

    Jun Ohshima, Miwa Sasai, Ji Su Ma, Youngae Lee, Hironori Bando, Kiyoshi Takeda, Masahiro Yamamoto

    第8回 寄生虫感染免疫研究会　2015/02

  57. Selective and strain-specific NFAT4 activation by the Toxoplasma gondii polymorphic dense granule protein GRA6

    Ji Su Ma, Miwa Sasai, Jun Ohshima, Youngae Lee, Hironori Bando, Kiyoshi Takeda, Masahiro Yamamoto

    第8回 寄生虫感染免疫研究会　2015/02

  58. Toxoplasma gondii GRA6 selectively activates NFAT4 to induce chemokine CXCL2 and CCL2

    Sasai M, Ma JiSu, Ohshima J, Lee Y, Takeda K, Yamamoto M.

    日本免疫学会学術集会　2014/12

  59. Role of mouse autophagy proteins in IFN-γ-mediated cell-autonomous responses against Toxoplasma gondii.

    Ohshima J, Sasai M, Ma JiSu, Lee Y, Takeda K, Yamamoto M.

    日本免疫学会学術集会　2014/12

  60. Human ATG16L1 and GBPs are dispensable for IFN-γ–dependent anti–Toxoplasma gondii responses

    Youngae Lee, Jun Ohshima, Miwa Sasai, Ji Su Ma, Masahiro Yamamoto.

    日本免疫学会学術集会　2014/12

  61. インターフェロン-γ;誘導性 GTPaseによるトキソプラズマ原虫殺傷機構について

    山本雅裕、大嶋淳、Lee Youngae、笹井美和

    第87回日本生化学会大会　2014/10

  62. NFAT4 activation by the Toxoplasma gondii polymorphic effector protein GRA6 maximizes the parasite virulence in a strain-specific manner

    Yamamoto M.

    The 13th Awaji International Forum on Infection and Immunity　2014/09

  63. Identification of natural compounds that inhibit growth of intracellular pathogens.

    Bui XT, Sasai M, Yamamoto M, Koburi T, and Nagai H

    第13回あわじしま感染症・免疫フォー ラム　2014/09

  64. トキソプラズマ原虫の免疫寄生虫学

    山本雅裕

    第16回免疫サマースクール2014 in 小豆島　2014/07

  65. トキソプラズマ原虫と宿主の免疫学的攻防

    Masahiro Yamamoto

    平成26年度 遺伝子病制御研究所研究集会　2014/07

  66. Activation of host NFAT by a Toxoplasmagondii polymorphic dense granule protein plays an important role in virulence mediated by the local infection

    Yamamoto M, Ma JS, Ohshima J, Sasai M

    18th Annual Woods Hole ImmunoParasitology Conference　2014/04

  67. IFN-γ依存的抗トキソプラズマ応答におけるオートファジー蛋白質の役割

    Yamamoto M, Oshima J, Su Ma J, Lee Y

    第83回日本寄生虫学会大会　2014/03

  68. Selective and strain-specific NFAT4 activation by the Toxoplasma gondii polymorphic dense granule protein GRA6

    Ji Su Ma, Miwa Sasai, Kiyoshi Takeda, Masahiro Yamamoto.

    日本免疫学会総会学術大会　2013/12

  69. Toxoplasam gondii Poluymorphic Dense Granule Protein GRA6 Selectively and strain-spcific activates NFAT4.

    Masahiro Yamamoto

    TCUID2013　2013/11

  70. Roles of de-ubiquitinating enzymes on the propagation of HCV

    Toru Okamoto, Yukari Sugiyama, Chikako Ono, Sayaka Aizawa, Pham Duc Ngoc, Takahisa Kohwaki, Eiji Hirooka, Takasuke Fukuhara, Masahiro Yamamoto, Yoshiharu Matsuura

    International Symposium on Hepatitis C Virus and Related Viruses　2013/10

  71. A protozoan parasite Toxoplasma gondii manipulates host cell functions by effector molecules

    Masahiro Yamamoto

    The XIVth International Congress of Protistology　2013/08

  72. Immunological interface between host and a protozoan parasite Toxoplasma gondii

    Masahiro Yamamoto

    FORUM GRADUATE SCHOOLS INFECTION & IMMUNITY BIOLOGIE-MEDECINE　2013/06

  73. インターフェロンガンマ依存性の細胞内侵入病原体排除におけるオートファジー関連タンパク質の役割の解明

    Jun Ooshima, Miwa Sasai, Masahiro Yamamot, Mikamo Hayashi

    日本歯科保存学会春季学術大会　2013/06

Industrial Property Rights 2

  1. TLR LIGAND AND IL-1 RESPONSE-INJURED ANIMAL MODEL

    特許第4236549号

    出願日:2004/04

    登録日:2005/05

  2. エンドトキシン不応答性モデル動物

    山本 雅裕, 審良 静男

    出願日:2003/09

Social Activities 3

  • 病原性寄生虫「トキソプラズマ」が起こす感染症のサイエンス

    SpringX 超学校 CiDER(大阪大学感染症総合教育研究拠点)×ナレッジキャピタル　正しく学ぶ! 感染症から「いのち」と「くらし」を守る講座

    2023/02 -

  • 大阪中学生サマー・セミナー

    大阪中学生サマーセミナー協議会

    2016/08 -

  • 第16回免疫サマースクール2014 in 小豆島

    日本免疫学会

    2014/07 -

Media Coverage 7

  1. マラリア予防に白血病治療薬が効果

    NHK

    2019/07

  2. マラリアが増える仕組み解明

    読売新聞

    2019/06

  3. C型肝炎ウイルス、薬剤耐性なく治療する化合物 阪大、アルツハイ マー病治療薬の候補の中に...トキソプラズマなども効果

    産経新聞

    2017/11

  4. 審良研で世界との熾烈な競争を経験、トキソプラズマと宿主の関係解明へ

    日経バイオテク2月15日号「若手研究者の肖像」（第10回）

    2016/02

  5. トキソプラズマ『トロイの木馬』現象 原因タンパク質 確認

    読売新聞

    2014/09

  6. 「ミチをひらく」下

    朝日新聞

    2014/06

  7. 「ミチをひらく」上

    朝日新聞

    2014/06

Academic Activities 6

  1. 第20回淡路感染と免疫国際フォーラム

    大阪大学微生物病研究所

    2022/09 -

  2. 新興・再興感染症制御プロジェクト 合同シンポジウム

    AMED

    2019/03 -

  3. 第１回 日本医学会連合Rising Starリトリート

    日本医学会連合

    2019/03 -

  4. The 3rd Asian Congress of Protistology & 10th Asian Conference of Ciliate Biology & 2nd International Symposium on Biodiversity and Evolution of Protozoa

    Asian Committee of Protistologists

    2018/11 -

  5. 第２６回分子寄生虫学ワークショップ/第16回分子寄生虫・マラリア研究フォーラム合同大会 特別企画・免疫

    日本寄生虫学会

    2018/09 -

  6. The 10th Japanese-German Immunology Workshop. Session 3: Uniqueness in the Development and Function of Innate Immunity.

    日独免疫学会議

    2018/09 -

Institutional Repository 7

Content Published in the University of Osaka Institutional Repository (OUKA)

  1. Recent advances in identifying and characterizing secretory proteins of Toxoplasma gondii by CRISPR-based screening

    Tachibana Yuta, Yamamoto Masahiro

    Parasitology International　Vol. 105　2025/04/01

  2. Toxoplasma GRA15 expression on dendritic cells inhibits B cell differentiation and antibody production

    Nakayama Yuki, Ihara Fumiaki, Okuzaki Daisuke, Nishikawa Yoshifumi, Sasai Miwa, Yamamoto Masahiro

    Parasitology International　Vol. 105　2025/04/01

  3. CRISPR screens identify genes essential for in vivo virulence among proteins of hyperLOPIT-unassigned subcellular localization in Toxoplasma

    Tachibana Yuta, Sasai Miwa, Yamamoto Masahiro

    mBio　Vol. 15　No. 9　2024/07/31

  4. Far-East Asian Toxoplasma isolates share ancestry with North and South/Central American recombinant lineages

    Ihara Fumiaki, Kyan Hisako, Takashima Yasuhiro, Ono Fumiko, Hayashi Kei, Matsuo Tomohide, Igarashi Makoto, Nishikawa Yoshifumi, Hikosaka Kenji, Sakamoto Hirokazu, Nakamura Shota, Motooka Daisuke, Yamauchi Kiyoshi, Ichikawa-Seki Madoka, Fukumoto Shinya, Sasaki Motoki, Ikadai Hiromi, Kusakisako Kodai, Ohari Yuma, Yoshida Ayako, Sasai Miwa, Grigg Michael E., Yamamoto Masahiro

    Nature Communications　Vol. 15　2024/05/22

  5. Host genetics highlights IFN-γ-dependent Toxoplasma genes encoding secreted and non-secreted virulence factors in in vivo CRISPR screens

    Tachibana Yuta, Hashizaki Emi, Sasai Miwa, Yamamoto Masahiro

    Cell Reports　Vol. 42　No. 6　2023/06/27

  6. インターフェロン誘導性遺伝子 GBP の発癌機構・癌細胞浸潤機構における役割の解明

    山本 雅裕

    癌と人　Vol. 41　p. 53-56　2014/05

  7. Role of Adaptor TRIF in the MyD88-Independent Toll-like Receptor Signaling Pathway

    山本 雅裕