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Yamamoto Masahiro

山本　雅裕

Research Institute for Microbial Diseases, Professor

myamamoto biken.osaka-u.ac.jp

Education

  • 2003/04 - 2006/03, Osaka University
  • 2001/04 - 2003/03, Osaka University, Graduate School of Medicine
  • 1999/04 - 2001/03, The University of Tokyo, Faculty of Science, Department of Biological Sciences
  • 1997/04 - 1999/03, The University of Tokyo, College of Arts and Sciences

Research History

  • 2018/12 - Present, Osaka University
  • 2013/07 - Present, Osaka University, Research Institute for Microbial Diseases
  • 2012/01 - 2013/06, Osaka University, Research Institute for Microbial Diseases
  • 2010/05 - 2011/12, Osaka University
  • 2007/04 - 2010/04, Osaka University, Graduate School of Medicine
  • 2006/08 - 2007/03, Osaka University, Graduate School of Medicine

Research Areas

  • Life sciences, Laboratory animal science
  • Life sciences, Parasitology
  • Life sciences, Veterinary medicine

Professional Memberships

  • 日本寄生虫学会
  • 日本免疫学会

Papers

  • A genetic method specifically delineates Th1-type Treg cells and their roles in tumor immunity., Masaaki Okamoto,Miwa Sasai,Ayumi Kuratani,Daisuke Okuzaki,Masaya Arai,James B Wing,Shimon Sakaguchi,Masahiro Yamamoto, Cell reports, Vol. 42, No. 7, p. 112813-112813, 2023/07/25
  • Host genetics highlights IFN-γ-dependent Toxoplasma genes encoding secreted and non-secreted virulence factors in in vivo CRISPR screens., Yuta Tachibana,Emi Hashizaki,Miwa Sasai,Masahiro Yamamoto, Cell reports, Vol. 42, No. 6, p. 112592-112592, 2023/06/01
  • Toxoplasma IWS1 Determines Fitness in Interferon-γ-Activated Host Cells and Mice by Indirectly Regulating ROP18 mRNA Expression., Emi Hashizaki,Miwa Sasai,Daisuke Okuzaki,Tsubasa Nishi,Takashi Kobayashi,Shiroh Iwanaga,Masahiro Yamamoto, mBio, Vol. 14, No. 1, 2023/02/28
  • Plasmodium UIS3 avoids host cell-autonomous exclusion that requires GABARAPs but not LC3 and autophagy, Ariel Pradipta,Hironori Bando,Ji Su Ma,Shun Tanaka,Miwa Sasai,Masahiro Yamamoto, Parasitology International, Vol. 83, 2021/08
  • Uncovering a novel role of PLCβ4 in selectively mediating TCR signaling in CD8+ but not CD4+ T cells., Miwa Sasai,Ji Su Ma,Masaaki Okamoto,Kohei Nishino,Hikaru Nagaoka,Eizo Takashima,Ariel Pradipta,Youngae Lee,Hidetaka Kosako,Pann-Ghill Suh,Masahiro Yamamoto, The Journal of experimental medicine, Vol. 218, No. 7, 2021/07/05
  • Cell-autonomous Toxoplasma killing program requires Irgm2 but not its microbe vacuolar localization., Ariel Pradipta,Miwa Sasai,Kou Motani,Ji Su Ma,Youngae Lee,Hidetaka Kosako,Masahiro Yamamoto, Life science alliance, Vol. 4, No. 7, 2021/07
  • Role of Gate-16 and Gabarap in Prevention of Caspase-11-Dependent Excess Inflammation and Lethal Endotoxic Shock, Naoya Sakaguchi,Miwa Sasai,Hironori Bando,Youngae Lee,Ariel Pradipta,Ji Su Ma,Masahiro Yamamoto, Frontiers in Immunology, Vol. 11, p. 561948-561948, 2020/09/15
  • T cell-derived interferon-γ is required for host defense to Toxoplasma gondii., Saishi Nishiyama,Ariel Pradipta,Ji Su Ma,Miwa Sasai,Masahiro Yamamoto, Parasitology international, Vol. 75, p. 102049-102049, 2020/04
  • Decision by injection without infection., Miwa Sasai,Masahiro Yamamoto, The Journal of experimental medicine, Vol. 217, No. 3, 2020/03/02
  • Initial phospholipid-dependent Irgb6 targeting to Toxoplasma gondii vacuoles mediates host defense., Youngae Lee,Hiroshi Yamada,Ariel Pradipta,Ji Su Ma,Masaaki Okamoto,Hikaru Nagaoka,Eizo Takashima,Daron M Standley,Miwa Sasai,Kohji Takei,Masahiro Yamamoto, Life science alliance, Vol. 3, No. 1, 2020/01
  • CXCR4 regulates Plasmodium development in mouse and human hepatocytes, Hironori Bando,Ariel Pradipta,Shiroh Iwanaga,Toru Okamoto,Daisuke Okuzaki,Shun Tanaka,Joel Vega-Rodríguez,Youngae Lee,Ji Su Ma,Naoya Sakaguchi,Akira Soga,Shinya Fukumoto,Miwa Sasai,Yoshiharu Matsuura,Masao Yuda,Marcelo Jacobs-Lorena,Masahiro Yamamoto, Journal of Experimental Medicine, Vol. 216, No. 8, p. 1733-1748, 2019/08/01
  • Toxoplasma Effector GRA15-Dependent Suppression of IFN-γ-Induced Antiparasitic Response in Human Neurons., Hironori Bando,Youngae Lee,Naoya Sakaguchi,Ariel Pradipta,Ryoma Sakamoto,Shun Tanaka,Ji Su Ma,Miwa Sasai,Masahiro Yamamoto, Frontiers in cellular and infection microbiology, Vol. 9, No. MAY, p. 140-140, 2019
  • Inducible Nitric Oxide Synthase Is a Key Host Factor for Toxoplasma GRA15-Dependent Disruption of the Gamma Interferon-Induced Antiparasitic Human Response., Hironori Bando,Youngae Lee,Naoya Sakaguchi,Ariel Pradipta,Ji Su Ma,Shun Tanaka,Yihong Cai,Jianfa Liu,Jilong Shen,Yoshifumi Nishikawa,Miwa Sasai,Masahiro Yamamoto, mBio, Vol. 9, No. 5, 2018/10/09
  • Toxoplasma Effector TgIST Targets Host IDO1 to Antagonize the IFN-γ-Induced Anti-parasitic Response in Human Cells., Hironori Bando,Naoya Sakaguchi,Youngae Lee,Ariel Pradipta,Ji Su Ma,Shun Tanaka,De-Hua Lai,Jianfa Liu,Zhao-Rong Lun,Yoshifumi Nishikawa,Miwa Sasai,Masahiro Yamamoto, Frontiers in immunology, Vol. 9, No. SEP, p. 2073-2073, 2018
  • Essential role for GABARAP autophagy proteins in interferon-inducible GTPase-mediated host defense., Miwa Sasai,Naoya Sakaguchi,Ji Su Ma,Shuhei Nakamura,Tsuyoshi Kawabata,Hironori Bando,Youngae Lee,Tatsuya Saitoh,Shizuo Akira,Akiko Iwasaki,Daron M Standley,Tamotsu Yoshimori,Masahiro Yamamoto, Nature immunology, Vol. 18, No. 8, p. 899-910, 2017/08
  • p62 Plays a Specific Role in Interferon-γ-Induced Presentation of a Toxoplasma Vacuolar Antigen., Youngae Lee,Miwa Sasai,Ji Su Ma,Naoya Sakaguchi,Jun Ohshima,Hironori Bando,Tatsuya Saitoh,Shizuo Akira,Masahiro Yamamoto, Cell reports, Vol. 13, No. 2, p. 223-33, 2015/10/13
  • RabGDIα is a negative regulator of interferon-γ-inducible GTPase-dependent cell-autonomous immunity to Toxoplasma gondii., Jun Ohshima,Miwa Sasai,Jianfa Liu,Kazuo Yamashita,Ji Su Ma,Youngae Lee,Hironori Bando,Jonathan C Howard,Shigeyuki Ebisu,Mikako Hayashi,Kiyoshi Takeda,Daron M Standley,Eva-Maria Frickel,Masahiro Yamamoto, Proceedings of the National Academy of Sciences of the United States of America, Vol. 112, No. 33, p. E4581-90-E4590, 2015/08/18
  • Selective and strain-specific NFAT4 activation by the Toxoplasma gondii polymorphic dense granule protein GRA6., Ji Su Ma,Miwa Sasai,Jun Ohshima,Youngae Lee,Hironori Bando,Kiyoshi Takeda,Masahiro Yamamoto, The Journal of experimental medicine, Vol. 211, No. 10, p. 2013-32, 2014/09/22
  • Role of mouse and human autophagy proteins in IFN-γ-induced cell-autonomous responses against Toxoplasma gondii., Jun Ohshima,Youngae Lee,Miwa Sasai,Tatsuya Saitoh,Ji Su Ma,Naganori Kamiyama,Yoshiharu Matsuura,Suh Pann-Ghill,Mikako Hayashi,Shigeyuki Ebisu,Kiyoshi Takeda,Shizuo Akira,Masahiro Yamamoto, Journal of immunology (Baltimore, Md. : 1950), Vol. 192, No. 7, p. 3328-35, 2014/04/01
  • A cluster of interferon-γ-inducible p65 GTPases plays a critical role in host defense against Toxoplasma gondii., Masahiro Yamamoto,Megumi Okuyama,Ji Su Ma,Taishi Kimura,Naganori Kamiyama,Hiroyuki Saiga,Jun Ohshima,Miwa Sasai,Hisako Kayama,Toru Okamoto,David C S Huang,Dominique Soldati-Favre,Kyoji Horie,Junji Takeda,Kiyoshi Takeda, Immunity, Vol. 37, No. 2, p. 302-13, 2012/08/24
  • ATF6beta is a host cellular target of the Toxoplasma gondii virulence factor ROP18., Masahiro Yamamoto,Ji Su Ma,Christina Mueller,Naganori Kamiyama,Hiroyuki Saiga,Emi Kubo,Taishi Kimura,Toru Okamoto,Megumi Okuyama,Hisako Kayama,Kisaburo Nagamune,Seiji Takashima,Yoshiharu Matsuura,Dominique Soldati-Favre,Kiyoshi Takeda, The Journal of experimental medicine, Vol. 208, No. 7, p. 1533-46, 2011/07/04
  • E2 polyubiquitin-conjugating enzyme Ubc13 in keratinocytes is essential for epidermal integrity, Koji Sayama,Masahiro Yamamoto,Yuji Shirakata,Yasushi Hanakawa,Satoshi Hirakawa,Xiuju Dai,Mikiko Tohyama,Sho Tokumaru,Myoung Sook Shin,Hiroaki Sakurai,Shizuo Akira,Koji Hashimoto, Journal of Biological Chemistry, Vol. 285, No. 39, p. 30042-30049, 2010/09/24
  • A single polymorphic amino acid on Toxoplasma gondii kinase ROP16 determines the direct and strain-specific activation of Stat3., Masahiro Yamamoto,Daron M Standley,Seiji Takashima,Hiroyuki Saiga,Megumi Okuyama,Hisako Kayama,Emi Kubo,Hiroshi Ito,Mutsumi Takaura,Tadashi Matsuda,Dominique Soldati-Favre,Kiyoshi Takeda, The Journal of experimental medicine, Vol. 206, No. 12, p. 2747-60, 2009/11/23
  • Enhanced TLR-mediated NF-IL6-dependent gene expression by Trib1 deficiency, Masahiro Yamamoto,Satoshi Uematsu,Toru Okamoto,Yoshiharu Matsuura,Shintaro Sato,Himanshu Kumar,Takashi Satoh,Tatsuya Saitoh,Kiyoshi Takeda,Ken J. Ishii,Osamu Takeuchi,Taro Kawai,Shizuo Akira, Journal of Experimental Medicine, Vol. 204, No. 9, p. 2233-2239, 2007/09/03
  • Cutting edge: Pivotal function of Ubc13 in thymocyte TCR signaling, Masahiro Yamamoto,Shintaro Sato,Tatsuya Saitoh,Hiroaki Sakurai,Satoshi Uematsu,Taro Kawai,Ken J. Ishii,Osamu Takeuchi,Shizuo Akira, Journal of Immunology, Vol. 177, No. 11, p. 7520-7524, 2006/12/01
  • Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling, Masahiro Yamamoto,Toru Okamoto,Kiyoshi Takeda,Shintaro Sato,Hideki Sanjo,Satoshi Uematsu,Tatsuya Saitoh,Naoki Yamamoto,Hiroaki Sakurai,Ken J. Ishii,Shoji Yamaoka,Taro Kawai,Yoshiharu Matsuura,Osamu Takeuchi,Shizuo Akira, Nature Immunology, Vol. 7, No. 9, p. 962-970, 2006/09
  • Regulation of Toll/IL-1-receptor-mediated gene expression by the inducible nuclear protein IκBζ, Masahiro Yamamoto,Soh Yamazaki,Satoshi Uematsu,Shintaro Sato,Hiroaki Hemmmi,Katsuaki Hoshino,Tsuneyasu Kaisho,Hirotaka Kuwata,Osamu Takeuchi,Koichiro Takeshige,Tatsuya Saitoh,Shoji Yamaoka,Naoki Yamamoto,Shunsuke Yamamoto,Tatsushi Muta,Kiyoshi Takeda,Shizuo Akira, Nature, Vol. 430, No. 6996, p. 218-222, 2004/07/08
  • TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway, Masahiro Yamamoto,Shintaro Sato,Hiroaki Hemmi,Satoshi Uematsu,Katsuaki Hoshino,Tsuneyasu Kaisho,Osamu Takeuchi,Kiyoshi Takeda,Shizuo Akira, Nature Immunology, Vol. 4, No. 11, p. 1144-1150, 2003/11
  • Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway, Masahiro Yamamoto,Shintaro Sato,Hiroaki Hemmi,Katsuaki Hoshino,Tsuneyasu Kaisho,Hideki Sanjo,Osamu Takeuchi,Masanaka Sugiyama,Masaru Okabe,Kiyoshi Takeda,Shizuo Akira, Science, Vol. 301, No. 5633, p. 640-643, 2003/08/01
  • Cutting edge: A novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-β promoter in the Toll-like receptor signaling, Masahiro Yamamoto,Shintaro Sato,Kiyotoshi Mori,Katsuaki Hoshino,Osamu Takeuchi,Kiyoshi Takeda,Shizuo Akira, Journal of Immunology, Vol. 169, No. 12, p. 6668-6672, 2002/12/15
  • Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4, Masahiro Yamamoto,Shintaro Sato,Hiroaki Hemmi,Hideki Sanjo,Satoshi Uematsu,Tsuneyasu Kaisho,Katsuaki Hoshino,Osamu Takeuchi,Masaya Kobayashi,Takashi Fujita,Kiyoshi Takeda,Shizuo Akira, Nature, Vol. 420, No. 6913, p. 324-329, 2002/11/21
  • The role of IFN-γ-mediated host immune responses in monitoring and the elimination of Toxoplasma gondii infection., Fumiaki Ihara,Masahiro Yamamoto, International immunology, Vol. 36, No. 5, p. 199-210, 2024/04/03
  • TCR Signals Controlling Adaptive Immunity against Toxoplasma and Cancer., Masaaki Okamoto,Masahiro Yamamoto, Advances in experimental medicine and biology, Vol. 1444, p. 177-193, 2024/03
  • 5,6-dimethylxanthenone-4-acetic acid (DMXAA), a partial STING agonist, competes for human STING activation., Burcu Temizoz,Takayuki Shibahara,Kou Hioki,Tomoya Hayashi,Kouji Kobiyama,Michelle Sue Jann Lee,Naz Surucu,Erdal Sag,Atsushi Kumanogoh,Masahiro Yamamoto,Mayda Gursel,Seza Ozen,Etsushi Kuroda,Cevayir Coban,Ken J Ishii, Frontiers in immunology, Vol. 15, p. 1353336-1353336, 2024/03
  • Structural basis of Irgb6 inactivation by Toxoplasma gondii through the phosphorylation of switch I., Hiromichi Okuma,Yumiko Saijo-Hamano,Hiroshi Yamada,Aalaa Alrahman Sherif,Emi Hashizaki,Naoki Sakai,Takaaki Kato,Tsuyoshi Imasaki,Satoshi Kikkawa,Eriko Nitta,Miwa Sasai,Tadashi Abe,Fuminori Sugihara,Yoshimasa Maniwa,Hidetaka Kosako,Kohji Takei,Daron M Standley,Masahiro Yamamoto,Ryo Nitta, Genes to cells : devoted to molecular & cellular mechanisms, Vol. 29, No. 1, p. 17-38, 2024/01
  • Amino acid catabolite markers for early prognostication of pneumonia in patients with COVID-19., Rae Maeda,Natsumi Seki,Yoshifumi Uwamino,Masatoshi Wakui,Yu Nakagama,Yasutoshi Kido,Miwa Sasai,Shu Taira,Naoya Toriu,Masahiro Yamamoto,Yoshiharu Matsuura,Jun Uchiyama,Genki Yamaguchi,Makoto Hirakawa,Yun-Gi Kim,Masayo Mishima,Motoko Yanagita,Makoto Suematsu,Yuki Sugiura, Nature communications, Vol. 14, No. 1, p. 8469-8469, 2023/12/20
  • PIM1 controls GBP1 activity to limit self-damage and to guard against pathogen infection., Daniel Fisch,Moritz M Pfleiderer,Eleni Anastasakou,Gillian M Mackie,Fabian Wendt,Xiangyang Liu,Barbara Clough,Samuel Lara-Reyna,Vesela Encheva,Ambrosius P Snijders,Hironori Bando,Masahiro Yamamoto,Andrew D Beggs,Jason Mercer,Avinash R Shenoy,Bernd Wollscheid,Kendle M Maslowski,Wojtek P Galej,Eva-Maria Frickel, Science (New York, N.Y.), Vol. 382, No. 6666, 2023/10/06
  • Retinal ferroptosis as a critical mechanism for the induction of retinochoroiditis during ocular toxoplasmosis., Kazuhisa Yamada,Akira Tazaki,Nanako Ushio-Watanabe,Yoshihiko Usui,Atsunobu Takeda,Masaaki Matsunaga,Ayana Suzumura,Hideyuki Shimizu,Hao Zheng,Nanang R Ariefta,Masahiro Yamamoto,Hideaki Hara,Hiroshi Goto,Koh-Hei Sonoda,Koji M Nishiguchi,Masashi Kato,Yoshifumi Nishikawa,Shinya Toyokuni,Hiroki Kaneko, Redox biology, Vol. 67, p. 102890-102890, 2023/09/17
  • Fusobacterium nucleatum infection activates the noncanonical inflammasome and exacerbates inflammatory response in DSS-induced colitis., Kotchakorn Boonyaleka,Tokuju Okano,Tamako Iida,Anongwee Leewananthawet,Miwa Sasai,Masahiro Yamamoto,Hiroshi Ashida,Toshihiko Suzuki, European journal of immunology, Vol. 53, No. 11, 2023/07/20
  • Immunity against Moraxella catarrhalis requires guanylate-binding proteins and caspase-11-NLRP3 inflammasomes., Daniel Enosi Tuipulotu,Shouya Feng,Abhimanu Pandey,Anyang Zhao,Chinh Ngo,Anukriti Mathur,Jiwon Lee,Cheng Shen,Daniel Fox,Yansong Xue,Callum Kay,Max Kirkby,Jordan Lo Pilato,Nadeem O Kaakoush,Daryl Webb,Melanie Rug,Avril Ab Robertson,Melkamu B Tessema,Stanley Pang,Daniel Degrandi,Klaus Pfeffer,Daria Augustyniak,Antje Blumenthal,Lisa A Miosge,Anne Brüstle,Masahiro Yamamoto,Patrick C Reading,Gaetan Burgio,Si Ming Man, The EMBO journal, Vol. 42, No. 6, 2023/03/15
  • TFEB-mediated lysosomal exocytosis alleviates high-fat diet-induced lipotoxicity in the kidney., Jun Nakamura,Takeshi Yamamoto,Yoshitsugu Takabatake,Tomoko Namba-Hamano,Satoshi Minami,Atsushi Takahashi,Jun Matsuda,Shinsuke Sakai,Hiroaki Yonishi,Shihomi Maeda,Sho Matsui,Isao Matsui,Takayuki Hamano,Masatomo Takahashi,Maiko Goto,Yoshihiro Izumi,Takeshi Bamba,Miwa Sasai,Masahiro Yamamoto,Taiji Matsusaka,Fumio Niimura,Motoko Yanagita,Shuhei Nakamura,Tamotsu Yoshimori,Andrea Ballabio,Yoshitaka Isaka, JCI insight, Vol. 8, No. 4, 2023/02/22
  • Macrophages inhibit Coxiella burnetii by the ACOD1-itaconate pathway for containment of Q fever., Lisa Kohl,Md Nur A Alam Siddique,Barbara Bodendorfer,Raffaela Berger,Annica Preikschat,Christoph Daniel,Martha Ölke,Elisabeth Liebler-Tenorio,Jan Schulze-Luehrmann,Michael Mauermeir,Kai-Ting Yang,Inaya Hayek,Manuela Szperlinski,Jennifer Andrack,Ulrike Schleicher,Aline Bozec,Gerhard Krönke,Peter J Murray,Stefan Wirtz,Masahiro Yamamoto,Valentin Schatz,Jonathan Jantsch,Peter Oefner,Daniel Degrandi,Klaus Pfeffer,Katja Mertens-Scholz,Simon Rauber,Christian Bogdan,Katja Dettmer,Anja Lührmann,Roland Lang, EMBO molecular medicine, Vol. 15, No. 2, 2023/02/08
  • ROP39 is an Irgb10-specific parasite effector that modulates acute Toxoplasma gondii virulence., Shishir Singh,Mateo Murillo-León,Niklas Sebastian Endres,Ailan Farid Arenas Soto,Jorge Enrique Gómez-Marín,Florence Melbert,Thirumala-Devi Kanneganti,Masahiro Yamamoto,Claudia Campos,Jonathan Charles Howard,Gregory Alan Taylor,Tobias Steinfeldt, PLoS pathogens, Vol. 19, No. 1, 2023/01/01
  • Modified DNA vaccine confers improved humoral immune response and effective virus protection against SARS-CoV-2 delta variant., Hiroki Hayashi,Jiao Sun,Yuka Yanagida,Takako Otera,Miwa Sasai,Chin Yang Chang,Jiayu A Tai,Tomoyuki Nishikawa,Kunihiko Yamashita,Naoki Sakaguchi,Shota Yoshida,Satoshi Baba,Munehisa Shimamura,Sachiko Okamoto,Yasunori Amaishi,Hideto Chono,Junichi Mineno,Hiromi Rakugi,Ryuichi Morishita,Masahiro Yamamoto,Hironori Nakagami, Scientific reports, Vol. 12, No. 1, p. 20923-20923, 2022/12/03
  • Immune response induced in rodents by anti-CoVid19 plasmid DNA vaccine via pyro-drive jet injector inoculation., Tomoyuki Nishikawa,Chin Yang Chang,Jiayu A Tai,Hiroki Hayashi,Jiao Sun,Shiho Torii,Chikako Ono,Yoshiharu Matsuura,Ryoko Ide,Junichi Mineno,Miwa Sasai,Masahiro Yamamoto,Hironori Nakagami,Kunihiko Yamashita, Immunological medicine, Vol. 45, No. 4, p. 251-264, 2022/12
  • Author Correction: LC3 lipidation is essential for TFEB activation during the lysosomal damage response to kidney injury., Shuhei Nakamura,Saki Shigeyama,Satoshi Minami,Takayuki Shima,Shiori Akayama,Tomoki Matsuda,Alessandra Esposito,Gennaro Napolitano,Akiko Kuma,Tomoko Namba-Hamano,Jun Nakamura,Kenichi Yamamoto,Miwa Sasai,Ayaka Tokumura,Mika Miyamoto,Yukako Oe,Toshiharu Fujita,Seigo Terawaki,Atsushi Takahashi,Maho Hamasaki,Masahiro Yamamoto,Yukinori Okada,Masaaki Komatsu,Takeharu Nagai,Yoshitsugu Takabatake,Haoxing Xu,Yoshitaka Isaka,Andrea Ballabio,Tamotsu Yoshimori, Nature cell biology, Vol. 24, No. 11, p. 1677-1679, 2022/11/01
  • Recruitment of Irgb6 to the membrane is a direct trigger for membrane deformation., Hiroshi Yamada,Tadashi Abe,Hikaru Nagaoka,Eizo Takashima,Ryo Nitta,Masahiro Yamamoto,Kohji Takei, Frontiers in cellular and infection microbiology, Vol. 12, p. 992198-992198, 2022/09/01
  • Anti-Toxoplasma host defense systems and the parasitic counterdefense mechanisms., Miwa Sasai,Masahiro Yamamoto, Parasitology international, Vol. 89, p. 102593-102593, 2022/08/01
  • Pathogen-selective killing by guanylate-binding proteins as a molecular mechanism leading to inflammasome signaling., Shouya Feng,Daniel Enosi Tuipulotu,Abhimanu Pandey,Weidong Jing,Cheng Shen,Chinh Ngo,Melkamu B Tessema,Fei-Ju Li,Daniel Fox,Anukriti Mathur,Anyang Zhao,Runli Wang,Klaus Pfeffer,Daniel Degrandi,Masahiro Yamamoto,Patrick C Reading,Gaetan Burgio,Si Ming Man, Nature communications, Vol. 13, No. 1, p. 4395-4395, 2022/07/29
  • A prospective cohort study of newborns born to mothers with serum Toxoplasma gondii immunoglobulin M positivity during pregnancy., Midori Hijikata,Ichiro Morioka,Aya Okahashi,Nobuhiko Nagano,Kaori Kawakami,Atsushi Komatsu,Kei Kawana,Shohei Ohyama,Kazumichi Fujioka,Kenji Tanimura,Masashi Deguchi,Miwa Sasai,Masahiro Yamamoto,Hideto Yamada, Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, Vol. 28, No. 4, p. 486-491, 2022/04/01
  • SARS-CoV-2 infection triggers paracrine senescence and leads to a sustained senescence-associated inflammatory response, Shunya Tsuji,Shohei Minami,Rina Hashimoto,Yusuke Konishi,Tatsuya Suzuki,Tamae Kondo,Miwa Sasai,Shiho Torii,Chikako Ono,Shintaro Shichinohe,Shintaro Sato,Masahiro Wakita,Shintaro Okumura,Sosuke Nakano,Tatsuyuki Matsudaira,Tomonori Matsumoto,Shimpei Kawamoto,Masahiro Yamamoto,Tokiko Watanabe,Yoshiharu Matsuura,Kazuo Takayama,Takeshi Kobayashi,Toru Okamoto,Eiji Hara, Nature Aging, Springer Science and Business Media LLC, Vol. 2, No. 2, p. 115-124, 2022/02
  • The IFN-inducible GTPase IRGB10 regulates viral replication and inflammasome activation during influenza A virus infection in mice., Shelbi Christgen,David E Place,Min Zheng,Benoit Briard,Masahiro Yamamoto,Thirumala-Devi Kanneganti, European journal of immunology, Vol. 52, No. 2, p. 285-296, 2022/02/01
  • Enterocyte-innate lymphoid cell crosstalk drives early IFN-γ-mediated control of Cryptosporidium., Jodi A Gullicksrud,Adam Sateriale,Julie B Engiles,Alexis R Gibson,Sebastian Shaw,Zachary A Hutchins,Lindsay Martin,David A Christian,Gregory A Taylor,Masahiro Yamamoto,Daniel P Beiting,Boris Striepen,Christopher A Hunter, Mucosal immunology, Vol. 15, No. 2, p. 362-372, 2022/02/01
  • Structural basis of membrane recognition of Toxoplasma gondii vacuole by Irgb6., Yumiko Saijo-Hamano,Aalaa Alrahman Sherif,Ariel Pradipta,Miwa Sasai,Naoki Sakai,Yoshiaki Sakihama,Masahiro Yamamoto,Daron M Standley,Ryo Nitta, Life science alliance, Vol. 5, No. 1, 2022/01/01
  • Macrophages Demonstrate Guanylate-Binding Protein-Dependent and Bacterial Strain-Dependent Responses to Francisella tularensis., Nasibeh Mohammadi,Helena Lindgren,Masahiro Yamamoto,Amandine Martin,Thomas Henry,Anders Sjöstedt, Frontiers in cellular and infection microbiology, Vol. 11, p. 784101-784101, 2021/12/24
  • High resistance to Toxoplasma gondii infection in inducible nitric oxide synthase knockout rats., Zhen-Jie Wang,Shao-Meng Yu,Jiang-Mei Gao,Peng Zhang,Geoff Hide,Masahiro Yamamoto,De-Hua Lai,Zhao-Rong Lun, iScience, Vol. 24, No. 11, p. 103280-103280, 2021/11/19
  • Chlamydia evasion of neutrophil host defense results in NLRP3 dependent myeloid-mediated sterile inflammation through the purinergic P2X7 receptor., Chunfu Yang,Lei Lei,John W Marshall Collins,Michael Briones,Li Ma,Gail L Sturdevant,Hua Su,Anuj K Kashyap,David Dorward,Kevin W Bock,Ian N Moore,Christine Bonner,Chih-Yu Chen,Craig A Martens,Stacy Ricklefs,Masahiro Yamamoto,Kiyoshi Takeda,Yoichiro Iwakura,Grant McClarty,Harlan D Caldwell, Nature communications, Springer Science and Business Media LLC, Vol. 12, No. 1, p. 5454-5454, 2021/09/15
  • An infectivity-enhancing site on the SARS-CoV-2 spike protein targeted by antibodies, Yafei Liu,Wai Tuck Soh,Jun ichi Kishikawa,Mika Hirose,Emi E. Nakayama,Songling Li,Miwa Sasai,Tatsuya Suzuki,Asa Tada,Akemi Arakawa,Sumiko Matsuoka,Kanako Akamatsu,Makoto Matsuda,Chikako Ono,Shiho Torii,Kazuki Kishida,Hui Jin,Wataru Nakai,Noriko Arase,Atsushi Nakagawa,Maki Matsumoto,Yukoh Nakazaki,Yasuhiro Shindo,Masako Kohyama,Keisuke Tomii,Koichiro Ohmura,Shiro Ohshima,Toru Okamoto,Masahiro Yamamoto,Hironori Nakagami,Yoshiharu Matsuura,Takayuki Kato,Masato Okada,Daron M. Standley,Tatsuo Shioda,Hisashi Arase, Cell, Vol. 184, No. 13, p. 3452-3.47E+21, 2021/06/24
  • Hepatitis C virus modulates signal peptide peptidase to alter host protein processing., Junki Hirano,Sachiyo Yoshio,Yusuke Sakai,Li Songling,Tatsuya Suzuki,Yumi Itoh,He Zhang,David Virya Chen,Saori Haga,Hiroko Oomori,Takahiro Kodama,Yusuke Maeda,Yoshihiro Ono,Yu Takahashi,Daron M Standley,Masahiro Yamamoto,Kohji Moriishi,Kyoji Moriya,Tatsuya Kanto,Tetsuo Takehara,Kazuhiko Koike,Yoshiharu Matsuura,Toru Okamoto, Proceedings of the National Academy of Sciences of the United States of America, Vol. 118, No. 22, 2021/06/01
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  • The thalamic mGluR1-PLCβ4 pathway is critical in sleep architecture, Joohyeon Hong,Jungryun Lee,Kiyeong Song,Go Eun Ha,Yong Ryoul Yang,Ji Su Ma,Masahiro Yamamoto,Hee Sup Shin,Pann Ghill Suh,Eunji Cheong, Molecular Brain, Vol. 9, No. 1, p. 100-100, 2016/12/21
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  • Fundamental Roles of the Golgi-Associated Toxoplasma Aspartyl Protease, ASP5, at the Host-Parasite Interface., Pierre-Mehdi Hammoudi,Damien Jacot,Christina Mueller,Manlio Di Cristina,Sunil Kumar Dogga,Jean-Baptiste Marq,Julia Romano,Nicolò Tosetti,Juan Dubrot,Yalin Emre,Matteo Lunghi,Isabelle Coppens,Masahiro Yamamoto,Daniel Sojka,Paco Pino,Dominique Soldati-Favre, PLoS pathogens, Vol. 11, No. 10, 2015/10
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  • Innate immune response induced by baculovirus attenuates transgene expression in mammalian cells, Chikako Ono,Akinori Ninomiya,Satomi Yamamoto,Takayuki Abe,Xiauyu Wen,Takasuke Fukuhara,Miwa Sasai,Masahiro Yamamoto,Tatsuya Saitoh,Takashi Satoh,Taro Kawai,Ken J. Ishii,Shizuo Akira,Toru Okamoto,Yoshiharu Matsuura, Journal of Virology, Vol. 88, No. 4, p. 2157-2167, 2014/02
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  • The E2-like conjugation enzyme Atg3 promotes binding of IRG and Gbp proteins to Chlamydia- and Toxoplasma-containing vacuoles and host resistance., Arun K Haldar,Anthony S Piro,Danielle M Pilla,Masahiro Yamamoto,Jörn Coers, PloS one, Vol. 9, No. 1, 2014
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  • Toll-like receptor 3 and 4 signalling through the TRIF and TRAM adaptors in haematopoietic cells promotes atherosclerosis, Anna M. Lundberg,Daniel F.J. Ketelhuth,Maria E. Johansson,Norbert Gerdes,Sang Liu,Masahiro Yamamoto,Shizuo Akira,Göran K. Hansson, Cardiovascular Research, Vol. 99, No. 2, p. 364-373, 2013/07/15
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  • Critical role of AIM2 in Mycobacterium tuberculosis infection, Hiroyuki Saiga,Shoko Kitada,Yosuke Shimada,Naganori Kamiyama,Megumi Okuyama,Masahiko Makino,Masahiro Yamamoto,Kiyoshi Takeda, International Immunology, Vol. 24, No. 10, p. 637-644, 2012/10
  • Probiotic Bifidobacterium breve induces IL-10-producing Tr1 cells in the colon, Seong Gyu Jeon,Hisako Kayama,Yoshiyasu Ueda,Takuya Takahashi,Takashi Asahara,Hirokazu Tsuji,Noriko M. Tsuji,Hiroshi Kiyono,Ji Su Ma,Takashi Kusu,Ryu Okumura,Hiromitsu Hara,Hiroki Yoshida,Masahiro Yamamoto,Koji Nomoto,Kiyoshi Takeda, PLoS Pathogens, Vol. 8, No. 5, 2012/05
  • Intestinal CX <inf>3</inf>C chemokine receptor 1 <sup>high</sup> (CX <inf>3</inf>CR1 <sup>high</sup>) myeloid cells prevent T-cell-dependent colitis, Hisako Kayama,Yoshiyasu Ueda,Yukihisa Sawa,Seong Gyu Jeon,Ji Su Ma,Ryu Okumura,Atsuko Kubo,Masaru Ishii,Taku Okazaki,Masaaki Murakami,Masahiro Yamamoto,Hideo Yagita,Kiyoshi Takeda, Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, No. 13, p. 5010-5015, 2012/03/27
  • Inhibition of ATF6β-dependent host adaptive immune response by a toxoplasma virulence factor ROP18, Masahiro Yamamoto,Kiyoshi Takeda, Virulence, Vol. 3, No. 1, p. 77-80, 2012
  • A method for the generation of conditional gene-targeted mice, Masahiro Yamamoto,Kiyoshi Takeda, Methods in Molecular Biology, Vol. 757, p. 399-410, 2011
  • Trib1 is a lipid- and myocardial infarction-associated gene that regulates hepatic lipogenesis and VLDL production in mice, Ralph Burkhardt,Sue Anne Toh,William R. Lagor,Andrew Birkeland,Michael Levin,Xiaoyu Li,Megan Robblee,Victor D. Fedorov,Masahiro Yamamoto,Takashi Satoh,Shizuo Akira,Sekar Kathiresan,Jan L. Breslow,Daniel J. Rader, Journal of Clinical Investigation, Vol. 120, No. 12, p. 4410-4414, 2010/12/01
  • Commensal microbiota induce LPS hyporesponsiveness in colonic macrophages via the production of IL-10, Yoshiyasu Ueda,Hisako Kayama,Seong Gyu Jeon,Takashi Kusu,Yoshitaka Isaka,Hiromi Rakugi,Masahiro Yamamoto,Kiyoshi Takeda, International Immunology, Vol. 22, No. 12, p. 953-962, 2010/12
  • Control of adipose tissue inflammation through TRB1, Anke Ostertag,Allan Jones,Adam J. Rose,Maria Liebert,Stefan Kleinsorg,Anja Reimann,Alexandros Vegiopoulos,Mauricio Berriel Diaz,Daniela Strzoda,Masahiro Yamamoto,Takashi Satoh,Shizuo Akira,Stephan Herzig, Diabetes, Vol. 59, No. 8, p. 1991-2000, 2010/08
  • A novel in vivo inducible dendritic cell ablation model in mice, Megumi Okuyama,Hisako Kayama,Koji Atarashi,Hiroyuki Saiga,Taishi Kimura,Ari Waisman,Masahiro Yamamoto,Kiyoshi Takeda, Biochemical and Biophysical Research Communications, Vol. 397, No. 3, p. 559-563, 2010/07
  • IκBη regulates T<inf>H</inf> 17 development by cooperating with ROR nuclear receptors, Kazuo Okamoto,Yoshiko Iwai,Masatsugu Oh-Hora,Masahiro Yamamoto,Tomohiro Morio,Kazuhiro Aoki,Keiichi Ohya,Anton M. Jetten,Shizuo Akira,Tatsushi Muta,Hiroshi Takayanagi, Nature, Vol. 464, No. 7293, p. 1381-1385, 2010/04
  • Current views of toll-like receptor signaling pathways, Kiyoshi Takeda,Masahiro Yamamoto, Gastroenterology Research and Practice, Vol. 2010, p. 240365-240365, 2010
  • Regulation of hematopoiesis by the K63-specific ubiquitin-conjugating enzyme Ubc13, Xuefeng Wu,Masahiro Yamamoto,Shizuo Akira,Shao Cong Sun, Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, No. 49, p. 20836-20841, 2009/12/08
  • Toll-like receptor 4 signalling through MyD88 is essential to control Salmonella enterica serovar Typhimurium infection, but not for the initiation of bacterial clearance, Suzanne Talbot,Sabine Tötemeyer,Masahiro Yamamoto,Shizuo Akira,Katherine Hughes,David Gray,Tom Barr,Pietro Mastroeni,Duncan J. Maskell,Clare E. Bryant, Immunology, Vol. 128, No. 4, p. 472-483, 2009/12
  • Two mechanistically and temporally distinct NF-κB activation pathways in IL-1 signaling, Kohsuke Yamazaki,Jin Gohda,Atsuhiro Kanayama,Yusei Miyamoto,Hiroaki Sakurai,Masahiro Yamamoto,Shizuo Akira,Hidetoshi Hayashi,Bing Su,Jun Ichiro Inoue, Science Signaling, Vol. 2, No. 93, 2009/10/20
  • NFATc1 mediates toll-like receptor-independent innate immune responses during Trypanosoma cruzi infection, Hisako Kayama,Ritsuko Koga,Koji Atarashi,Megumi Okuyama,Taishi Kimura,Tak W. Mak,Satoshi Uematsu,Shizuo Akira,Hiroshi Takayanagi,Kenya Honda,Masahiro Yamamoto,Kiyoshi Takeda, PLoS Pathogens, Vol. 5, No. 7, 2009/07
  • [Host immune response to Trypanosoma cruzi and its evasion mechanism]., Masahiro Yamamoto,Kiyoshi Takeda, Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, Vol. 54, No. 8 Suppl, p. 1053-1058, 2009/06
  • TRAF6 is required for generation of the B-1a B cell compartment as well as T cell-dependent and-independent humoral immune responses, Takashi Kobayashi,Tae Soo Kim,Anand Jacob,Matthew C. Walsh,Yuho Kadono,Ezequiel Fuentes-Pananá,Tomoko Yoshioka,Akihiko Yoshimura,Masahiro Yamamoto,Tsuneyasu Kaisho,Shizuo Akira,John G. Monroe,Yongwon Choi, PLoS ONE, Vol. 4, No. 3, 2009/03/09
  • Lipid a receptor TLR4-mediated signaling pathways, Shizuo Akira,Masahiro Yamamoto, Advances in Experimental Medicine and Biology, Vol. 667, p. 59-68, 2009
  • Fra-1 negatively regulates lipopolysaccharide-mediated inflammatory responses, Hideaki Morishita,Fumiji Saito,Hisako Kayama,Koji Atarashi,Hirotaka Kuwata,Masahiro Yamamoto,Kiyoshi Takeda, International Immunology, Vol. 21, No. 4, p. 457-465, 2009
  • Involvement of linear polyubiquitylation of NEMO in NF-κB activation, Fuminori Tokunaga,Shin Ichi Sakata,Yasushi Saeki,Yoshinori Satomi,Takayoshi Kirisako,Kiyoko Kamei,Tomoko Nakagawa,Michiko Kato,Shigeo Murata,Shoji Yamaoka,Masahiro Yamamoto,Shizuo Akira,Toshifumi Takao,Keiji Tanaka,Kazuhiro Iwai, Nature Cell Biology, Vol. 11, No. 2, p. 123-132, 2009
  • Lipocalin 2-dependent inhibition of mycobacterial growth in alveolar epithelium, Hiroyuki Saiga,Junichi Nishimura,Hirotaka Kuwata,Megumi Okuyama,Sohkichi Matsumoto,Shintaro Sato,Makoto Matsumoto,Shizuo Akira,Yasunobu Yoshikai,Kenya Honda,Masahiro Yamamoto,Kiyoshi Takeda, Journal of Immunology, Vol. 181, No. 12, p. 8521-8527, 2008/12/15
  • Gene-specific requirement of a nuclear protein, IκB-ζ, for promoter association of inflammatory transcription regulators, Soh Yamazaki,Susumu Matsuo,Tatsushi Muta,Masahiro Yamamoto,Shizuo Akira,Koichiro Takeshige, Journal of Biological Chemistry, Vol. 283, No. 47, p. 32404-32411, 2008/11/21
  • ATP drives lamina propria T<inf>H</inf>17 cell differentiation, Koji Atarashi,Junichi Nishimura,Tatsuichiro Shima,Yoshinori Umesaki,Masahiro Yamamoto,Masaharu Onoue,Hideo Yagita,Naoto Ishii,Richard Evans,Kenya Honda,Kiyoshi Takeda, Nature, Vol. 455, No. 7214, p. 808-812, 2008/10/09
  • Noncanonical E2 variant-independent function of UBC13 in promoting checkpoint protein assembly, Michael S.Y. Huen,Jun Huang,Jingsong Yuan,Masahiro Yamamoto,Shizuo Akira,Carolyn Ashley,Wei Xiao,Junjie Chen, Molecular and Cellular Biology, Vol. 28, No. 19, p. 6104-6112, 2008/10
  • Stat6-independent tissue inflammation occurs selectively on the ocular surface and perioral skin of IκBζ<sup>-/-</sup> mice, Mayumi Ueta,Junji Hamuro,Eiichiro Ueda,Norito Katoh,Masahiro Yamamoto,Kiyoshi Takeda,Shizuo Akira,Shigeru Kinoshita, Investigative Ophthalmology and Visual Science, Vol. 49, No. 8, p. 3387-3394, 2008/08
  • Role of nuclear IκB proteins in the regulation of host immune responses, Masahiro Yamamoto,Kiyoshi Takeda, Journal of Infection and Chemotherapy, Vol. 14, No. 4, p. 265-269, 2008/08
  • Virulent Salmonella enterica infections can be exacerbated by concomitant infection of the host with a live attenuated S. enterica vaccine via Toll-like receptor 4-dependent interleukin-10 production with the involvement of both TRIF and MyD88, Gemma L. Foster,Tom A. Barr,Andrew J. Grant,Trevelyan J. McKinley,Clare E. Bryant,Andrew MacDonald,David Gray,Masahiro Yamamoto,Shizuo Akira,Duncan J. Maskell,Pietro Mastroeni, Immunology, Vol. 124, No. 4, p. 469-479, 2008/08
  • Class-specific regulation of pro-inflammatory genes by MyD88 pathways and IκBζ, Hisako Kayama,Vladimir R. Ramirez-Carrozzi,Masahiro Yamamoto,Taketoshi Mizutani,Hirotaka Kuwata,Hideo Iba,Makoto Matsumoto,Kenya Honda,Stephen T. Smale,Kiyoshi Takeda, Journal of Biological Chemistry, Vol. 283, No. 18, p. 12468-12477, 2008/05/02
  • Potent antimycobacterial activity of mouse secretory leukocyte protease inhibitor, Junichi Nishimura,Hiroyuki Saiga,Shintaro Sato,Megumi Okuyama,Hisako Kayama,Hirotaka Kuwata,Sohkichi Matsumoto,Toshirou Nishida,Yoshiki Sawa,Shizuo Akira,Yasunobu Yoshikai,Masahiro Yamamoto,Kiyoshi Takeda, Journal of Immunology, Vol. 180, No. 6, p. 4032-4039, 2008/03/15
  • Assessing the response of cells to TLR stimulation, Kiyoshi Takeda,Masahiro Yamamoto,Kenya Honda, Signaling by Toll-Like Receptors, p. 1-21, 2008/01/01
  • The human T-cell leukemia virus type 1 tax oncoprotein requires the ubiquitin-conjugating enzyme Ubc13 for NF-κB activation, Noula Shembade,Nicole S. Harhaj,Masahiro Yamamoto,Shizuo Akira,Edward W. Harhaj, Journal of Virology, Vol. 81, No. 24, p. 13735-13742, 2007/12
  • FADD negatively regulates lipopolysaccharide signaling by impairing interleukin-1 receptor-associated kinase 1-MyD88 interaction, Rachel Zhande,Shauna M. Dauphinee,James A. Thomas,Masahiro Yamamoto,Shizuo Akira,Aly Karsan, Molecular and Cellular Biology, Vol. 27, No. 21, p. 7394-7404, 2007/11
  • The C/EBPβ isoform 34-kDa LAP is responsible for NF-IL-6-mediated gene induction in activated macrophages, but is not essential for intracellular bacteria killing, Satoshi Uematsu,Tsuneyasu Kaisho,Takashi Tanaka,Makoto Matsumoto,Megumi Yamakami,Hiroko Omori,Masahiro Yamamoto,Tamotsu Yoshimori,Shizuo Akira, Journal of Immunology, Vol. 179, No. 8, p. 5378-5386, 2007/10/15
  • Salmonella-induced SipB-independent cell death requires Toll-like receptor-4 signalling via the adapter proteins Tram and Trif, Pamela Cook,Sabine Tötemeyer,Catherine Stevenson,Katherine A. Fitzgerald,Masahiro Yamamoto,Shizuo Akira,Duncan J. Maskell,Clare E. Bryant, Immunology, Vol. 122, No. 2, p. 222-229, 2007/10
  • Role for MyD88-independent, TRIF pathway in lipid A/TLR4-induced endotoxin tolerance, Subhra K. Biswas,Pradeep Bist,Manprit Kaur Dhillon,Tasneem Kajiji,Carlos Del Fresno,Masahiro Yamamoto,Eduardo Lopez-Collazo,Shizuo Akira,Vinay Tergaonkar, Journal of Immunology, Vol. 179, No. 6, p. 4083-4092, 2007/09/15
  • Essential role of IRAK-4 protein and its kinase activity in Toll-like receptor-mediated immune responses but not in TCR signaling, Tatsukata Kawagoe,Shintaro Sato,Andreas Jung,Masahiro Yamamoto,Kosuke Matsui,Hiroki Kato,Satoshi Uematsu,Osamu Takeuchi,Shizuo Akira, Journal of Experimental Medicine, Vol. 204, No. 5, p. 1013-1024, 2007/05
  • Toll/IL-1 receptor domain-containing adaptor inducing IFN-β (TRIF)-mediated signaling contributes to innate immune responses in the lung during Escherichia coli pneumonia, Samithamby Jeyaseelan,Scott K. Young,Michael B. Fessler,Yuhong Liu,Kenneth C. Malcolm,Masahiro Yamamoto,Shizuo Akira,G. Scott Worthen, Journal of Immunology, Vol. 178, No. 5, p. 3153-3160, 2007/03/01
  • A role of Toll-IL-1 receptor domain-containing adaptor-inducing IFN-β in the host response to Pseudomonas aeruginosa lung infection in mice, Melanie R. Power,Bo Li,Masahiro Yamamoto,Shizuo Akira,Tong Jun Lin, Journal of Immunology, Vol. 178, No. 5, p. 3170-3176, 2007/03/01
  • NF-κB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1, Sinead M. Miggin,Eva Pålsson-McDermott,Aisling Dunne,Caroline Jefferies,Emmanuel Pinteaux,Kathy Banahan,Caroline Murphy,Paul Moynagh,Masahiro Yamamoto,Shizuo Akira,Nancy Rothwell,Douglas Golenbock,Katherine A. Fitzgerald,Luke A.J. O'Neill, Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, No. 9, p. 3372-3377, 2007/02/27
  • Pathological role of Toll-like receptor signaling in cerebral malaria, Cevayir Coban,Satoshi Uematsu,Nobuko Arisue,Shintaro Sato,Masahiro Yamamoto,Taro Kawai,Osamu Takeuchi,Hajime Hisaeda,Toshihiro Horii,Shizuo Akira, International Immunology, Vol. 19, No. 1, p. 67-79, 2007/01
  • VP1686, a Vibrio type III secretion protein, induces Toll-like receptor-independent apoptosis in macrophage through NF-κB inhibition, Rabindra N. Bhattacharjee,Kwon Sam Park,Yutaro Kumagai,Kazuhisa Okada,Masahiro Yamamoto,Satoshi Uematsu,Kosuke Matsui,Himanshu Kumar,Taro Kawai,Tetsuya Iida,Takeshi Honda,Osamu Takeuchi,Shizuo Akira, Journal of Biological Chemistry, Vol. 281, No. 48, p. 36897-36904, 2006/12/01
  • TLR-dependent induction of IFN-β mediates host defense against Trypanosoma cruzi, Ritsuko Koga,Shinjiro Hamano,Hirotaka Kuwata,Koji Atarashi,Masahiro Ogawa,Hajime Hisaeda,Masahiro Yamamoto,Shizuo Akira,Kunisuke Himeno,Makoto Matsumoto,Kiyoshi Takeda, Journal of Immunology, Vol. 177, No. 10, p. 7059-7066, 2006/11/15
  • The myeloid differentiation factor 88 is dispensable for the development of a delayed host response to Pseudomonas aeruginosa lung infection in mice, M. R. Power,J. S. Marshall,M. Yamamoto,S. Akira,T. J. Lin, Clinical and Experimental Immunology, Vol. 146, No. 2, p. 323-329, 2006/11
  • TAK1 is indispensable for development of T cells and prevention of colitis by the generation of regulatory T cells, Shintaro Sato,Hideki Sanjo,Tohru Tsujimura,Jun Ninomiya-Tsuji,Masahiro Yamamoto,Taro Kawai,Osamu Takeuchi,Shizuo Akira, International Immunology, Vol. 18, No. 10, p. 1405-1411, 2006/10
  • Detection of pathogenic intestinal bacteria by Toll-like receptor 5 on intestinal CD11c<sup>+</sup> lamina propria cells, Satoshi Uematsu,Myoung Ho Jang,Nicolas Chevrier,Zijin Guo,Yutaro Kumagai,Masahiro Yamamoto,Hiroki Kato,Nagako Sougawa,Hidenori Matsui,Hirotaka Kuwata,Hiroaki Hemmi,Cevayir Coban,Taro Kawai,Ken J. Ishii,Osamu Takeuchi,Masayuki Miyasaka,Kiyoshi Takeda,Shizuo Akira, Nature Immunology, Vol. 7, No. 8, p. 868-874, 2006/08
  • Essential role of IPS-1 in innate immune responses against RNA viruses, Himanshu Kumar,Taro Kawai,Hiroki Kato,Shintaro Sato,Ken Takahashi,Cevayir Coban,Masahiro Yamamoto,Satoshi Uematsu,Ken J. Ishii,Osamu Takeuchi,Shizuo Akira, Journal of Experimental Medicine, Vol. 203, No. 7, p. 1795-1803, 2006/07/10
  • Toll/IL-1R domain-containing adaptor protein (TIRAP) is a critical mediator of antibacterial defense in the lung against Klebsiella pneumoniae but not Pseudomonas aeruginosa, Samithamby Jeyaseelan,Scott K. Young,Masahiro Yamamoto,Patrick G. Arndt,Shizuo Akira,Jay K. Kolls,G. Scott Worthen, Journal of Immunology, Vol. 177, No. 1, p. 538-547, 2006/07/01
  • Negative regulation of interferon-regulatory factor 3-dependent innate antiviral response by the prolyl isomerase Pin1, Tatsuya Saitoh,Adrian Tun-Kyi,Akihide Ryo,Masahiro Yamamoto,Greg Finn,Takashi Fujita,Shizuo Akira,Naoki Yamamoto,Kun Ping Lu,Shoji Yamaoka, Nature Immunology, Vol. 7, No. 6, p. 598-605, 2006/06
  • Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses, Hiroki Kato,Osamu Takeuchi,Shintaro Sato,Mitsutoshi Yoneyama,Masahiro Yamamoto,Kosuke Matsui,Satoshi Uematsu,Andreas Jung,Taro Kawai,Ken J. Ishii,Osamu Yamaguchi,Kinya Otsu,Tohru Tsujimura,Chang Sung Koh,Caetano Reis E Sousa,Yoshiharu Matsuura,Takashi Fujita,Shizuo Akira, Nature, Vol. 441, No. 1, p. 101-105, 2006/05/04
  • "Endogenous adjuvant" activity of the RNA components of lupus auto antigens Sm/RNP and Ro 60, Kindra M. Kelly,Haoyang Zhuang,Dina C. Nacionales,Philip O. Scumpia,Robert Lyons,Jun Akaogi,Pui Lee,Bryan Williams,Masahiro Yamamoto,Shizuo Akira,Minoru Satoh,Westley H. Reeves, Arthritis and Rheumatism, Vol. 54, No. 5, p. 1557-1567, 2006/05
  • Erratum: A toll-like receptor-independent antiviral response induced by double-stranded B-form DNA (Nature Immunology (2005) vol. 7 (40-48)), Ken J. Ishii,Cevayir Coban,Hiroki Kato,Ken Takahashi,Yuichi Torii,Fumihiko Takeshita,Holger Ludwig,Gerd Sutter,Koichi Suzuki,Hiroaki Hemmi,Shintaro Sato,Masahiro Yamamoto,Satoshi Uematsu,Taro Kawai,Osamu Takeuchi,Shizuo Akira, Nature Immunology, Vol. 7, No. 4, 2006/04
  • The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction, Daniel C. Rowe,Anne F. McGettrick,Eicke Latz,Brian G. Monks,Nicholas J. Gay,Masahiro Yamamoto,Shizuo Akira,Luke A. O'Neill,Katherine A. Fitzgerald,Douglas T. Golenbock, Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, No. 16, p. 6299-6304, 2006/04
  • Mechanism of pathogen-specific TLR4 activation in the mucosa: Fimbriae, recognition receptors and adaptor protein selection, Hans Fischer,Masahiro Yamamoto,Shizuo Akira,Bruce Beutler,Catharina Svanborg, European Journal of Immunology, Vol. 36, No. 2, p. 267-277, 2006/02
  • A toll-like receptor-independent antiviral response induced by double-stranded B-form DNA, Ken J. Ishii,Cevayir Coban,Hiroki Kato,Ken Takahashi,Yuichi Torii,Fumihiko Takeshita,Holger Ludwig,Gerd Sutter,Koichi Suzuki,Hiroaki Hemmi,Shintaro Sato,Masahiro Yamamoto,Satoshi Uematsu,Taro Kawai,Osamu Takeuchi,Shizuo Akira, Nature Immunology, Vol. 7, No. 1, p. 40-48, 2006/01
  • BS69, a specific adaptor in the latent membrane protein 1-mediated c-Jun N-terminal kinase pathway, Jun Wan,Wei Zhang,Liming Wu,Ting Bai,Mingjie Zhang,Kwok Wai Lo,Yiu Ioon Chui,Yan Cui,Qian Tao,Masahiro Yamamoto,Shizuo Akira,Zhenguo Wu, Molecular and Cellular Biology, Vol. 26, No. 2, p. 448-456, 2006/01
  • Toll-IL-1 receptor domain-containing adaptor protein is critical for early lung immune responses against Escherichia coli lipopolysaccharide and viable Escherichia coli, Samithamby Jeyaseelan,Rizwan Manzer,Scott K. Young,Masahiro Yamamoto,Shizuo Akira,Robert J. Mason,G. Scott Worthen, Journal of Immunology, Vol. 175, No. 11, p. 7484-7495, 2005/12/01
  • Essential function for the kinase TAK1 in innate and adaptive immune responses, Shintaro Sato,Hideki Sanjo,Kiyoshi Takeda,Jun Ninomiya-Tsuji,Masahiro Yamamoto,Taro Kawai,Kunihiro Matsumoto,Osamu Takeuchi,Shizuo Akira, Nature Immunology, Vol. 6, No. 11, p. 1087-1095, 2005/11
  • The RNA helicase Lgp2 inhibits TLR-independent sensing of viral replication by retinoic acid-inducible gene-I, Simon Rothenfusser,Nadege Goutagny,Gary DiPerna,Mei Gong,Brian G. Monks,Annett Schoenemeyer,Masahiro Yamamoto,Shizuo Akira,Katherine A. Fitzgerald, Journal of Immunology, Vol. 175, No. 8, p. 5260-5268, 2005/10/15
  • Priming effect of lipopolysaccharide on acetyl-coenzyme A: Lyso-platelet-activating factor acetyltransferase is MyD88 and TRIF independent, Hideo Shindou,Satoshi Ishii,Masahiro Yamamoto,Kiyoshi Takeda,Shizuo Akira,Takao Shimizu, Journal of Immunology, Vol. 175, No. 2, p. 1177-1183, 2005/07/15
  • Cell type-specific involvement of RIG-I in antiviral response, Hiroki Kato,Shintaro Sato,Mitsutoshi Yoneyama,Masahiro Yamamoto,Satoshi Uematsu,Kosuke Matsui,Tohru Tsujimura,Kiyoshi Takeda,Takashi Fujita,Osamu Takeuchi,Shizuo Akira, Immunity, Vol. 23, No. 1, p. 19-28, 2005/07
  • Induction of CXCL5 during inflammation in the rodent lung involves activation of alveolar epithelium, Samithamby Jeyaseelan,Rizwan Manzer,Scott K. Young,Masahiro Yamamoto,Shizuo Akira,Robert J. Mason,G. Scott Worthen, American Journal of Respiratory Cell and Molecular Biology, Vol. 32, No. 6, p. 531-539, 2005/06
  • Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-α induction, Satoshi Uematsu,Shintaro Sato,Masahiro Yamamoto,Tomonori Hirotani,Hiroki Kato,Fumihiko Takeshita,Michiyuki Matsuda,Cevayir Coban,Ken J. Ishii,Taro Kawai,Osamu Takeuchi,Shizuo Akira, Journal of Experimental Medicine, Vol. 201, No. 6, p. 915-923, 2005/03/21
  • The nuclear IκB protein IκBNS selectively inhibits lipopolysaccharide-induced IL-6 production in macrophages of the colonic lamina propria, Tomonori Hirotani,Pui Y. Lee,Hirotaka Kuwata,Masahiro Yamamoto,Makoto Matsumoto,Ichiro Kawase,Shizuo Akira,Kiyoshi Takeda, Journal of Immunology, Vol. 174, No. 6, p. 3650-3657, 2005/03/15
  • Regulation of lipopolysaccharide-inducible genes by MyD88 and Toll/IL-1 domain containing adaptor inducing IFN-β, Tomonori Hirotani,Masahiro Yamamoto,Yutaro Kumagai,Satoshi Uematsu,Ichiro Kawase,Osamu Takeuchi,Shizuo Akira, Biochemical and Biophysical Research Communications, Vol. 328, No. 2, p. 383-392, 2005/03/11
  • A20 is a negative regulator of IFN regulatory factor 3 signaling, Tatsuya Saitoh,Masahiro Yamamoto,Makoto Miyagishi,Kazunari Taira,Makoto Nakanishi,Takashi Fujita,Shizuo Akira,Naoki Yamamoto,Shoji Yamaoka, Journal of Immunology, Vol. 174, No. 3, p. 1507-1512, 2005/02/01
  • Spontaneous ocular surface inflammation and goblet cell disappearance in IκBζ gene-disrupted mice, Mayumi Ueta,Junji Hamuro,Masahiro Yamamoto,Kazuhiro Kaseda,Shizuo Akira,Shigeru Kinoshita, Investigative Ophthalmology and Visual Science, Vol. 46, No. 2, p. 579-588, 2005/02
  • Roles of Stat3 and ERK in G-CSF signaling., Kenjirou Kamezaki,Kazuya Shimoda,Akihiko Numata,Takashi Haro,Haruko Kakumitsu,Masumi Yoshie,Masahiro Yamamoto,Kiyoshi Takeda,Tadashi Matsuda,Shizuo Akira,Katsuhiro Ogawa,Mine Harada, Stem cells (Dayton, Ohio), Vol. 23, No. 2, p. 252-63, 2005/02
  • Toll-like receptor 9 mediates innate immune activation by the malaria pigment hemozoin, Cevayir Coban,Ken J. Ishii,Taro Kawai,Hiroaki Hemmi,Shintaro Sato,Satoshi Uematsu,Masahiro Yamamoto,Osamu Takeuchi,Sawako Itagaki,Nirbhay Kumar,Toshihiro Horii,Shizuo Akira, Journal of Experimental Medicine, Vol. 201, No. 1, p. 19-25, 2005/01/03
  • Mechanisms of innate immune responses mediated by Toll-like receptors, Masahiro Yamamoto,Shizuo Akira, Clinical and Applied Immunology Reviews, Vol. 5, No. 3, p. 167-183, 2005
  • TIR domain-containing adaptors regulate TLR signaling pathways, Masahiro Yamamoto,Shizuo Akira, Advances in Experimental Medicine and Biology, Vol. 560, p. 1-9, 2005
  • IFN regulatory factor 3-dependent induction of type I IFNs by intracellular bacteria is mediated by a TLR- and Nod2-independent mechanism, Silvia Stockinger,Benjamin Reutterer,Barbara Schaljo,Carola Schellack,Sylvia Brunner,Tilo Materna,Masahiro Yamamoto,Shizuo Akira,Tadatsugu Taniguchi,Peter J. Murray,Mathias Müller,Thomas Decker, Journal of Immunology, Vol. 173, No. 12, p. 7416-7425, 2004/12/15
  • TIR domain--containing adaptors regulate TLR-mediated signaling pathways, Masahiro Yamamoto,Shizuo Akira, Nippon rinsho. Japanese journal of clinical medicine, Vol. 62, No. 12, p. 2197-2203, 2004/12
  • ASC is essential for LPS-induced activation of procaspase-1 independently of TLR-associated signal adaptor molecules, Masatatsu Yamamoto,Katsuyuki Yaginuma,Hiroko Tsutsui,Junji Sagara,Xin Guan,Ekihiro Seki,Koubun Yasuda,Masahiro Yamamoto,Shizuo Akira,Kenji Nakanishi,Tetsuo Noda,Shun'ichiro Taniguchi, Genes to Cells, Vol. 9, No. 11, p. 1055-1067, 2004/11
  • Activation of TBK1 and IKKε kinases by vesicular stomatitis virus infection and the role of viral ribonucleoprotein in the development of interferon antiviral immunity, Benjamin R. TenOever,Sonia Sharma,Wen Zou,Qiang Sun,Nathalie Grandvaux,Ilkka Julkunen,Hiroaki Hemmi,M. Yamamoto,Shizuo Akira,Wen Chen Yeh,Rongtuan Lin,John Hiscott, Journal of Virology, Vol. 78, No. 19, p. 10636-10649, 2004/10
  • Interferon-α induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6, Taro Kawai,Shintaro Sato,Ken J. Ishii,Cevayir Coban,Hiroaki Hemmi,Masahiro Yamamoto,Kenta Terai,Michiyuki Matsuda,Jun Ichiro Inoue,Satoshi Uematsu,Osamu Takeuchi,Shizuo Akira, Nature Immunology, Vol. 5, No. 10, p. 1061-1068, 2004/10
  • MyD88 but not TRIF is essential for osteoclastogenesis induced by lipopolysaccharide, diacyl lipopeptide, and IL-1α, Nobuaki Sato,Naoyuki Takahashi,Koji Suda,Midori Nakamura,Mariko Yamaki,Tadashi Ninomiya,Yasuhiro Kobayashi,Haruhiko Takada,Kenichiro Shibata,Masahiro Yamamoto,Kiyoshi Takeda,Shizuo Akira,Toshihide Noguchi,Nobuyuki Udagawa, Journal of Experimental Medicine, Vol. 200, No. 5, p. 601-611, 2004/09/06
  • The roles of two IκB kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infection, Hiroaki Hemmi,Osamu Takeuchi,Shintaro Sato,Masahiro Yamamoto,Tsuneyasu Kaisho,Hideki Sanjo,Taro Kawai,Katsuaki Hoshino,Kiyoshi Takeda,Shizuo Akira, Journal of Experimental Medicine, Vol. 199, No. 12, p. 1641-1650, 2004/06/21
  • TIR domain-containing adaptors define the specificity of TLR signaling, Masahiro Yamamoto,Kiyoshi Takeda,Shizuo Akira, Molecular Immunology, Vol. 40, No. 12, p. 861-868, 2004/02
  • IL-10-inducible Bcl-3 negatively regulates LPS-induced TNF-α production in macrophages, Hirotaka Kuwata,Yasuyuki Watanabe,Hiroyuki Miyoshi,Masahiro Yamamoto,Tsuneyasu Kaisho,Kiyoshi Takeda,Shizuo Akira, Blood, Vol. 102, No. 12, p. 4123-4129, 2003/12/01
  • Toll/IL-1 receptor domain-containing adaptor inducing IFN-β (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-κB and IFN-regulatory factor-3, in the toll-like receptor signaling, Shintaro Sato,Masanaka Sugiyama,Masahiro Yamamoto,Yasuyuki Watanabe,Taro Kawai,Kiyoshi Takeda,Shizuo Akira, Journal of Immunology, Vol. 171, No. 8, p. 4304-4310, 2003/10/15
  • Role of adapters in Toll-like receptor signalling, S. Akira,M. Yamamoto,K. Takeda, Biochemical Society Transactions, Vol. 31, No. 3, p. 637-642, 2003/06

Misc.

  • Gate-16 is required for LC3-independent antimicrobial host defense through cytosolic distribution of interferon-inducible GTPases, Miwa Sasai,Masahiro Yamamoto, CYTOKINE, ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, Vol. 100, p. 29-29, 2017/12
  • Mechanisms of Toxoplasma gondii virulence by regulating host immunity, Vol. 64, No. 6, p. 533-539, 2015/12
  • Regulation of Toxoplasmosis by cell-autonomous innate immunity, Vol. 64, No. 4, p. 410-415, 2015/10
  • Negative regulation of host innate immune responses by a Toxoplasma kinase ROP16, Clinical immunology & allergology, Vol. 55, No. 1, p. 54-60, 2011/01
  • Conditional ablation of Ubc13 in keratinocytes induces abnormal differentiation, decreased proliferation, and apoptosis, Koji Sayama,Yuji Shirakata,Yasushi Hanakawa,Satoshi Hirakawa,Xiuju Dai,Masahiro Yamamoto,Shizuo Akira,Koji Hashimoto, JOURNAL OF DERMATOLOGY, WILEY-BLACKWELL PUBLISHING, INC, Vol. 37, p. 33-33, 2010/09
  • Regulation of T cell receptor signaling by ubiquitin ligases, Clinical immunology & allergology, Vol. 48, No. 4, p. 421-427, 2007/10
  • Regulation of endotoxin tolerance by myeloid differentiation factor 88-independent signaling and its downstream cytokine, interferon beta, Subhra K. Biswas,Pradeep Bist,Manprit Dhillon,Tasneem Kajiji,Carlos Del Fresno,Masahiro Yamamoto,Eduardo Lopez-Collazo,Shizuo Akira,Vinay Tergaonkar, CYTOKINE, ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, Vol. 39, No. 1, p. 3-3, 2007/07
  • Effects of combined TLR stimulation on interleukin-27 mRNA expression in human monocyte-derived dendritic cells, Sinead M. Migpin,Eva Palsson-McDermott,Aisling Dunne,Caroline Jefferies,Emmanuel Pinteaux,Kathy Banahan,Caroline Murphy,Paul Moynagh,Masahiro Yamamoto,Shizuo Akira,Nancy Rothwell,Douglas Golenbock,Katherine A. Fitzgerald,Luke A. J. O'Neill, CYTOKINE, ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD, Vol. 39, No. 1, p. 27-28, 2007/07
  • IRAK-1はTLR7とTLR9を解するIFN-α産生に必須の役割を果たす, 植松智,佐藤慎太郎,山本雅裕,加藤博己,石井健,河合太郎,竹内理,竹内理,審良静男,審良静男, 日本免疫学会総会・学術集会記録, Vol. 35, 2005
  • The roles of stat3 and ERK in G-CSF signaling., K Kamezaki,K Shimoda,A Numata,M Yoshie,M Yamamoto,K Takeda,T Matsuda,S Akira,K Ogawa,M Harada, BLOOD, AMER SOC HEMATOLOGY, Vol. 104, No. 11, p. 597A-597A, 2004/11
  • 2本鎖RNAにより活性化されるTLR3依存性,非依存性経路の機能的相違, 改正 恒康,邊見 弘明,山本 雅裕,竹内 理,星野 克明,審良 静男, 日本免疫学会総会・学術集会記録, (NPO)日本免疫学会, Vol. 34, p. 200-200, 2004/11
  • アダプター分子によるMyD88依存的経路とMyD88非依存的経路の制御--TIRAPとTRIFの役割 (免疫2004) -- (自然免疫), 山本 雅裕,竹田 潔,審良 静男, 免疫, 中山書店, Vol. 2004, p. 201-209, 2004
  • TLRの病原体認識特異性とシグナル伝達経路機構, 山本雅裕, 医学のあゆみ 別冊自然免疫と疾患, 2004
  • RIG-I欠損マウスの作成および解析, 加藤博己,佐藤慎太郎,山本雅裕,松井孝介,植松智,竹田潔,竹内理,審良静男, 日本免疫学会総会・学術集会記録, Vol. 34, 2004
  • Plasmacytoid DCにおけるToll-like receptor 9によるtype Iインターフェロンの誘導機構, 植松智,佐藤慎太郎,山本雅裕,加藤博己,石井健,河合太郎,竹内理,審良静男, 日本免疫学会総会・学術集会記録, Vol. 34, 2004
  • Toll様受容体を介したI型IFN産生誘導のメカニズム, 河合太郎,佐藤慎太郎,石井健,COBAN C,辺見弘明,山本雅裕,植松智,竹内理,審良静男, 日本免疫学会総会・学術集会記録, Vol. 34, 2004
  • TRIFはTLRのMyD88非依存的経路を担うアダプター分子である, 山本 雅裕,佐藤 慎太郎,辺見 弘明,改正 恒康,星野 克明,竹田 潔,審良 静男, 日本免疫学会総会・学術集会記録, (NPO)日本免疫学会, Vol. 33, p. 122-122, 2003/11
  • TBK1/NAK/T2KはLPSによるIFN-inducible geneの発現に関与する, 邊見 弘明,佐藤 慎太郎,山本 雅裕,改正 恒康,河合 太郎,星野 克明,竹田 潔,審良 静男, 日本免疫学会総会・学術集会記録, (NPO)日本免疫学会, Vol. 33, p. 123-123, 2003/11
  • Toll-like receptor 研究の最前線, 山本 雅裕,審良 静男, 臨床と微生物 = Clinical microbiology, Vol. 30, No. 3, p. 249-253, 2003/05/25
  • TIRAP/MalはTLR4シグナルだけでなく,TLR2シグナルにも関わっている, 山本雅裕,佐藤慎太郎,辺見弘明,山条秀樹,植松智,改正恒康,星野克明,竹田潔,審良静男, 日本免疫学会総会・学術集会記録, Vol. 32, 2002

Industrial Property Rights

  • TLR LIGAND AND IL-1 RESPONSE-INJURED ANIMAL MODEL, 特許第4236549号, 2004-124758, 出願日:2004/04, 登録日:2005/05
  • エンドトキシン不応答性モデル動物, 山本 雅裕,審良 静男, 2003-338013, 出願日:2003/09

Awards

  • 第58回 小島三郎記念文化賞, 黒住医学研究振興財団, 2022/10
  • 野本賞, 日本微生物学連盟, 2020/09
  • 第67回 小泉賞, 日本寄生虫学会, 2020/05
  • 第１５回 日本学術振興会賞, 山本 雅裕, 日本学術振興会, 2019/02
  • 第15回（平成30年度）日本学術振興会賞, 2019/02
  • 第二回 日本医療研究開発機構ＡＭＥＤ理事長賞, 山本 雅裕, 内閣府, 2018/12
  • 第2回日本医療研究開発大賞 AMED理事長賞, 2018/12
  • Highly Cited Researchers 2017, Masahiro Yamamoto, Clarivate Analytics, 2017/12
  • Highly Cited Researchers 2016, 山本 雅裕, Clarivate Analytics(旧トムソン・ロイター IP&Science), 2016/11
  • 科学技術分野の文部科学大臣 表彰 若手科学者, 山本雅裕, 文部科学省, 2011/04
  • 科学技術分野の文部科学大臣 表彰若手科学者, 文部科学省, 2011/04
  • 第2回 日本免疫学会研究奨励賞, 日本免疫学会, 2007/12
  • 日本免疫学会研究奨励賞, 山本雅裕, 日本免疫学会, 2007/11
  • 山村賞, 山本雅裕, 大阪大学大学院医学系研究科, 2006/03

Presentations

  • Recognition of PLAMP by cell-autonomous immunity is important for anti-Toxoplasma host defense, 山本 雅裕, 第20回あわじ感染と免疫国際フォーラム, 2022/09
  • Role of PLCbeta4 in CD8+ T cell signaling, 2021/12
  • 肝臓期マラリア原虫の分化を制御する宿主因子の同定, 山本 雅裕, 第72回日本細菌学会九州支部総会 第56回日本ウイルス学会九州支部総会, 2019/09
  • Role of CXCR4 in liver stage Plasmodium development, Masahiro Yamamoto, The 18th Awaji International Forum on Infection and Immunity, 2019/09
  • 常在グラム陰性細菌に対するCaspase-11インフラマソームの制御機構, 山本 雅裕, 第84回日本インターフェロン・サイトカイン学会学術集会, 2019/08
  • 肝臓期マラリアの分化に関与する宿主因子の同定, 山本 雅裕, 第27回分子寄生虫学ワークショップ/第17回分子寄生虫・マラリア研究フォーラム合同大会, 2019/08
  • Molecular basis of Toxoplasma PV membrane targeting by Irgb6, Masahiro Yamamoto, The XVth International Toxoplasma Congress, 2019/06
  • Cell-intrinsic host defense and microbial counterdefense, Masahiro Yamamoto, International Molecular Immunology & Immunogenetics congress, 2019/04
  • Toxoplasma GRA15-dependent suppression of IFN-gamma-induced anti-parasitic response, Masahiro Yamamoto, 23th Annual Woods Hole ImmunoParasitology Conference, 2019/04
  • 病原性寄生虫トキソプラズマと宿主免疫の攻防, 山本 雅裕, 第１回 日本医学会連合Rising Starリトリート, 2019/03
  • トキソプラズマの寄生虫免疫学から導かれた意外な創薬ターゲット, 山本 雅裕, 新興・再興感染症制御プロジェクト 合同シンポジウム, 2019/03
  • Targeted disruption of IFN-γ-induced IDO1-dependent anti-parasitic response in human cells by Toxoplasma effector TgIST, Masahiro Yamamoto, The 3rd Asian Congress of Protistology & 10th Asian Conference of Ciliate Biology & 2nd International Symposium on Biodiversity and Evolution of Protozoa, 2018/11
  • トキソプラズマの宿主免疫返り討ち戦法について, 山本雅裕, 第２６回分子寄生虫学ワークショップ/第16回分子寄生虫・マラリア研究フォーラム合同大会, 2018/09
  • Role of cell-intrinsic and innate immunity by interferon-inducible GTPases, Masahiro Yamamoto, The 10th Japanese-German Immunology Workshop, 2018/09
  • Host cell-intrinsic host defense and counter defenses against Toxoplasma, Masahiro Yamamoto, ICOPA2018 Biology and interaction of host/cell and Toxoplasma gondii infection, 2018/08
  • IFNγによる宿主免疫系におけるオートファジー関連分子群の非標準的役割, 山本雅裕, 日本インターフェロン・サイトカイン学会 シンポジウム２, 2018/07
  • 感染防御免疫系におけるATG8ファミリー分子群の役割, 山本雅裕, 千里ライフサイエンスセミナー M2 オートファジーと疾患, 2018/06
  • Essential role of ATG proteins in cell-autonomous innate immunity to vacuolar pathogens, Masahiro Yamamoto, 15th International Conference on Innate Immunity, 2018/06
  • 肝臓機マラリア原虫の文化に重要な宿主因子の探索, 山本雅裕, 第７０回日本衛星動物学会大会, 2018/05
  • Role of Atg8 in the regulation of NLRP3 inflammasome-mediated pyroptosis, Masahiro Yamamoto, Australia-Japan Meeting on Cell Death, 2018/05
  • Suppression of human IFN-γ-mediated anti-parasitic cell-autonomous immunity by a Toxoplasma effector, Masahiro Yamamoto, Intrisic Defenses and Counterdefenses Keystone Symposia, 2018/03
  • A family member of phospholipase C is required for CD8 T cell-mediated anti-Toxoplasma host defense, Masahiro Yamamoto, WHIP 2018 22th Annual Woods Hole ImmunoParasitology Conference, 2018/03
  • Critical roles of GABARAPs on interferon-mediated cell-autonomous immune responses against T. gondii infection, Miwa Sasai, Naoya Sakaguchi, Ji Su Ma, Youngae Lee, Hironori Bando, Shizuo Akira, Masahiro Yamamoto, 第46回 日本免疫学会学術集会, 2017/12
  • PLCβ plays an important role in CD8 T cell-mediated host defense against Toxoplasma gondii, Ji Su Ma, Miwa Sasai, Youngae Lee, Naoya Sakaguchi, Hironori Bando, Masahiro Yamamoto, 第46回 日本免疫学会学術集会, 2017/12
  • Role of GABARAP subfamily in the regulation of non-canonical inflammasome activation, Naoya Sakaguchi, Ji Su Ma, Youngae Lee, Hironori Bando, Miwa Sasai, Masahiro Yamamoto, 第46回 日本免疫学会学術集会, 2017/12
  • Immunoparasitology of Toxoplasma gondii, Masahiro Yamamoto, The 2nd Annual International Conference and Exhibition on Indonesian Medical Education and Research Institute(IMERI) 2017, 2017/12
  • A mechanism of interferon-γ-induced anti-Toxoplasma gondii host defense, Masahiro Yamamoto, The 7th International Symposium on Parasitology, 2017/10
  • The Mammalian Atg8 Gabarap Subfamily Play a Non-Redundant Key Role in IFN-γ-Inducible GTPase-Dependent Host Defense Against Vacuolar Pathogens, Miwa Sasai, Naoya Sakaguchi, Ji SuMa, Youngae Lee, Hironori Bando, Masahiro Yamamoto, 第16回 あわじしま感染症・免疫フォーラム, 2017/09
  • Atg8ファミリーのインターフェロン誘導性自然免疫における役割について, 山本 雅裕, 笹井 美和, 坂口 直哉, 馬 知秀, The 3rd Annual Meeting of Japanese Society of Osteoimmunology 2017 ISHIGAKI, 2017/06
  • GABARAPs are required for the LC3-Independent antimicrobial host defense through cytosolic distribution of Interferon-Inducible GTPases, Miwa Sasai, Masahiro Yamamoto, 8th International symposium on Autophagy, 2017/05
  • GABARAPs are required for LC3s-independent anti-Toxoplasma gondii host defense through cytosolic distribution of interferon-inducible GTPases, Masahiro Yamamoto, Toxo-14 (The Toxoplasma gondii research community biennial meeting 2017), 2017/05
  • Critical role of GABARAP Atg8 subfamily in IFN-γ-induced cell-autonomous immunity to Toxoplasma gondii, Masahiro Yamamoto, 21th Annual Woods Hole ImmunoParasitology Conference, 2017/04
  • PLCβ4 plays an important role in CD8 T cell-mediated host defense against Toxoplasma gondii, Ji Su Ma, Miwa Sasai,Youngae Lee,Hironori Bando, and Masahiro Yamamoto, 第10回 寄生虫感染免疫研究会, 2017/02
  • Essential role of Gate-16 in anti-Toxoplasma gondii immune response, Miwa Sasai, Ji Su Ma, Youngae Lee, Hironori Bando, Masahiro Yamamoto, 第10回 寄生虫感染免疫研究会, 2017/02
  • Interferon-induced activation of cell-autonomous immunity against vacuolar pathogens, Masahiro Yamamoto, The 45th Annual meeting of the Japanese Society for Immunology, 2016/12
  • The Atg8 family members play a critical role in non-autophagic cell-autonomous immunity to vacuolar pathogens, Miwa Sasai, Naoya Sakaguchi, Masahiro Yamamoto, Keystome symposia, 2016/12
  • A mechanism for interferon-γ-induced ubiquitin decoration of Toxoplasma gondii parasitophorous vacuoles, Youngae Lee, Miwa Sasai, Ji Su Ma, Naoya Sakaguchi, Hironori Bando, Ariel Pradipta, and Masahiro Yamamoto, Forum Cheju18 Korea-Japan Parasitologists’Seminar, 2016/10
  • Mechanism of IFN-γ-inducible cell-autonomous immunity to intracellular pathogens, 山本 雅裕, Awaji Yumebutai International Conference Center on Awaji Island, 2016/09
  • インターフェロンγによる細胞内寄生性病原体の排除機構, 山本 雅裕, 第81回日本インターフェロン・サイトカイン学会学術集会, 2016/05
  • ヒト細胞におけるIFNγ依存的な抗トキソプラズマ応答にはIDO2ではなくIDO1が重要な役割を果たす, 伴戸 寛徳、笹井 美和、馬 知秀、李 英愛、坂口 直哉、山本 雅裕, 第85回 日本寄生虫学会大会, 2016/03
  • オートファジーアダプター分子p62はインターフェロンγ誘導性のトキソプラズマの寄生胞抗原の提示に特異的に関与する, 山本雅裕、李栄愛、笹井美和、馬知秀、伴戸博徳、坂口直哉, 第85回 日本寄生虫学会大会, 2016/03
  • p62/Sqstm1 plays a specific role in CD8+ T cell activation by antigen-presenting cells after IFN-γ-induced disruption of the parasitophorous vacuoles of Toxoplasma gondii, Masahiro Yamamoto, Youngae Lee, 第9回 寄生虫感染免疫研究会, 2016/02
  • FN-γ-inducible cell-autonomous immunity to intracellular pathogens, Masahiro Yamamoto, The 7th International Symposium of IFReC, 2016/01
  • インターフェロンγ誘導性GTPaseによるトキソプラズマ寄生胞の破壊制御機構, 山本 雅裕, 第38回日本分子生物学会年会、第88回日本生化学会大会 合同大会, 2015/12
  • p62 plays a specific role in IFN-g-induced presentation of a Toxoplasma vacuolar antigen, Youngae Lee, Miwa Sasai, Ji Su Ma, Naoya Sakaguchi, Jun Ohshima, Hironori Bando, Tatsuya Saitoh, Shizuo Akira, and Masahiro Yamamoto, The 44th Annual Meeting of The Japanese Society for Immunology, 2015/11
  • RabGDIα is a negative regulator of interferon-γ-inducible GTPase-dependent cell-autonomous immunity to Toxoplasma gondii, Miwa Sasai, Jun Ohshima, Ji Su Ma, Youngae Lee, Kiyoshi Takeda, Masahiro Yamamoto, The 44th Annual Meeting of The Japanese Society for Immunology, 2015/11
  • p62 plays a specific role in IFN-g-induced presentation of a Toxoplasma vacuolar antigen, Youngae Lee, Miwa Sasai, Ji Su Ma, Naoya Sakaguchi, Jun Ohshima, Hironori Bando, Tatsuya Saitoh, Shizuo Akira, and Masahiro Yamamoto, Forum Cheju17, 2015/11
  • Selective and strain-specific NFAT4 activation by the Toxoplasma gondii polymorphic dense granule protein GRA6, Ji Su Ma, Miwa Sasai, Jun Ohshima, Youngae Lee, Hironori Bando, Kiyoshi Takeda, and Masahiro Yamamoto, Forum Cheju17, 2015/11
  • トキソプラズマ病原性因子による免疫ハイジャック機構, Yamamoto M, 第158回日本獣医学会学術集会 シンポジウム, 2015/09
  • 宿主免疫系によるトキソプラズマ原虫の排除機構とその破綻の分子機構, Yamamoto M, 第27回 日本比較免疫学会学術集会 シンポジウム, 2015/08
  • Positive and Negative Regulation of IFN-γ-inducible GTPase-dependent cell-autonomous immunity to Toxoplasma gondii, Yamamoto M, RIKEN IMS-JSI International Symposium on Immunology 2015, 2015/06
  • 肝臓期マラリア原虫を標的とした新規抗マラリア薬の開発, 伴戸 寛徳, 笹井 美和, 馬 知秀, 大嶋 淳, 李 英愛, 山本 雅裕, 第84回日本寄生虫学会大会, 2015/03
  • トキソプラズマ原虫の多型濃縮顆粒タンパク質GRA6による選択的NFAT4の活性化について, 馬 知秀, 笹井 美和, 大嶋 淳, 李 英愛, 伴戸 寛徳, 竹田 潔, 山本 雅裕, 第84回日本寄生虫学会大会, 2015/03
  • トキソプラズマ病原性因子GRA6による宿主免疫乗っ取り機構, 山本 雅裕, 感染症国際研究センター/共同研究拠点 若手ジョイントシンポジウム, 2015/02
  • RabGDIα is a negative regulator of interferon-γ-inducible GTPase-dependent cell-autonomous host defense against Toxoplasma gondii, Jun Ohshima, Miwa Sasai, Ji Su Ma, Youngae Lee, Hironori Bando, Kiyoshi Takeda, Masahiro Yamamoto, 第8回 寄生虫感染免疫研究会, 2015/02
  • Selective and strain-specific NFAT4 activation by the Toxoplasma gondii polymorphic dense granule protein GRA6, Ji Su Ma, Miwa Sasai, Jun Ohshima, Youngae Lee, Hironori Bando, Kiyoshi Takeda, Masahiro Yamamoto, 第8回 寄生虫感染免疫研究会, 2015/02
  • Toxoplasma gondii GRA6 selectively activates NFAT4 to induce chemokine CXCL2 and CCL2, Sasai M, Ma JiSu, Ohshima J, Lee Y, Takeda K, Yamamoto M., 日本免疫学会学術集会, 2014/12
  • Role of mouse autophagy proteins in IFN-γ-mediated cell-autonomous responses against Toxoplasma gondii., Ohshima J, Sasai M, Ma JiSu, Lee Y, Takeda K, Yamamoto M., 日本免疫学会学術集会, 2014/12
  • Human ATG16L1 and GBPs are dispensable for IFN-γ–dependent anti–Toxoplasma gondii responses, Youngae Lee, Jun Ohshima, Miwa Sasai, Ji Su Ma, Masahiro Yamamoto., 日本免疫学会学術集会, 2014/12
  • インターフェロン-γ;誘導性 GTPaseによるトキソプラズマ原虫殺傷機構について, 山本雅裕、大嶋淳、Lee Youngae、笹井美和, 第87回日本生化学会大会, 2014/10
  • NFAT4 activation by the Toxoplasma gondii polymorphic effector protein GRA6 maximizes the parasite virulence in a strain-specific manner, Yamamoto M., The 13th Awaji International Forum on Infection and Immunity, 2014/09
  • Identification of natural compounds that inhibit growth of intracellular pathogens., Bui XT, Sasai M, Yamamoto M, Koburi T, and Nagai H, 第13回あわじしま感染症・免疫フォー ラム, 2014/09
  • トキソプラズマ原虫の免疫寄生虫学, 山本雅裕, 第16回免疫サマースクール2014 in 小豆島, 2014/07
  • トキソプラズマ原虫と宿主の免疫学的攻防, Masahiro Yamamoto, 平成26年度 遺伝子病制御研究所研究集会, 2014/07
  • Activation of host NFAT by a Toxoplasmagondii polymorphic dense granule protein plays an important role in virulence mediated by the local infection, Yamamoto M, Ma JS, Ohshima J, Sasai M, 18th Annual Woods Hole ImmunoParasitology Conference, 2014/04
  • IFN-γ依存的抗トキソプラズマ応答におけるオートファジー蛋白質の役割, Yamamoto M, Oshima J, Su Ma J, Lee Y, 第83回日本寄生虫学会大会, 2014/03
  • Selective and strain-specific NFAT4 activation by the Toxoplasma gondii polymorphic dense granule protein GRA6, Ji Su Ma, Miwa Sasai, Kiyoshi Takeda, Masahiro Yamamoto., 日本免疫学会総会学術大会, 2013/12
  • Toxoplasam gondii Poluymorphic Dense Granule Protein GRA6 Selectively and strain-spcific activates NFAT4., Masahiro Yamamoto, TCUID2013, 2013/11
  • Roles of de-ubiquitinating enzymes on the propagation of HCV, Toru Okamoto, Yukari Sugiyama, Chikako Ono, Sayaka Aizawa, Pham Duc Ngoc, Takahisa Kohwaki, Eiji Hirooka, Takasuke Fukuhara, Masahiro Yamamoto, Yoshiharu Matsuura, International Symposium on Hepatitis C Virus and Related Viruses, 2013/10
  • A protozoan parasite Toxoplasma gondii manipulates host cell functions by effector molecules, Masahiro Yamamoto, The XIVth International Congress of Protistology, 2013/08
  • Immunological interface between host and a protozoan parasite Toxoplasma gondii, Masahiro Yamamoto, FORUM GRADUATE SCHOOLS INFECTION & IMMUNITY BIOLOGIE-MEDECINE, 2013/06
  • インターフェロンガンマ依存性の細胞内侵入病原体排除におけるオートファジー関連タンパク質の役割の解明, Jun Ooshima, Miwa Sasai, Masahiro Yamamot, Mikamo Hayashi, 日本歯科保存学会春季学術大会, 2013/06

Media Coverage

  • マラリア予防に白血病治療薬が効果, NHK, 2019/07
  • マラリアが増える仕組み解明, 読売新聞, 2019/06
  • C型肝炎ウイルス、薬剤耐性なく治療する化合物 阪大、アルツハイ マー病治療薬の候補の中に...トキソプラズマなども効果, 産経新聞, 2017/11
  • 審良研で世界との熾烈な競争を経験、トキソプラズマと宿主の関係解明へ, 日経バイオテク2月15日号「若手研究者の肖像」（第10回）, 2016/02
  • トキソプラズマ『トロイの木馬』現象 原因タンパク質 確認, 読売新聞, 2014/09
  • 「ミチをひらく」下, 朝日新聞, 2014/06
  • 「ミチをひらく」上, 朝日新聞, 2014/06

Academic Activities

  • 第20回淡路感染と免疫国際フォーラム, 大阪大学微生物病研究所, 2022/09 -
  • 新興・再興感染症制御プロジェクト 合同シンポジウム, AMED, 2019/03 -
  • 第１回 日本医学会連合Rising Starリトリート, 日本医学会連合, 2019/03 -
  • The 3rd Asian Congress of Protistology & 10th Asian Conference of Ciliate Biology & 2nd International Symposium on Biodiversity and Evolution of Protozoa, Asian Committee of Protistologists, 2018/11 -
  • 第２６回分子寄生虫学ワークショップ/第16回分子寄生虫・マラリア研究フォーラム合同大会 特別企画・免疫, 日本寄生虫学会, 2018/09 -
  • The 10th Japanese-German Immunology Workshop. Session 3: Uniqueness in the Development and Function of Innate Immunity., 日独免疫学会議, 2018/09 -

Social Activities

  • 病原性寄生虫「トキソプラズマ」が起こす感染症のサイエンス, SpringX 超学校 CiDER(大阪大学感染症総合教育研究拠点)×ナレッジキャピタル, 正しく学ぶ! 感染症から「いのち」と「くらし」を守る講座, 2023/02 -
  • 大阪中学生サマー・セミナー, 大阪中学生サマーセミナー協議会, 2016/08 -
  • 第16回免疫サマースクール2014 in 小豆島, 日本免疫学会, 2014/07 -