Serum Mac-2 binding protein level predicts the development of liver-related events and colorectal cancer in patients with NAFLD.

Yoshihiro Kamada, Takashi Nakahara, Kensuke Munekage, Hideki Fujii, Yoshiyuki Sawai, Yoshinori Doi, Masafumi Ono, Hideyuki Hyogo, Yoshio Sumida, Koichi Morishita, Tatsuya Asuka, Tsunenori Ouchida, Yasuharu Imai, Eiji Miyoshi

Hepatology communications　Vol. 6　No. 7　p. 1527-1536　2022/04/27　Research paper (scientific journal)

Clinical Outcomes in Biopsy-Proven Nonalcoholic Fatty Liver Disease Patients: A Multicenter Registry-Based Cohort Study.

Hideki Fujii, Michihiro Iwaki, Hideki Hayashi, Hidenori Toyoda, Satoshi Oeda, Hideyuki Hyogo, Miwa Kawanaka, Asahiro Morishita, Kensuke Munekage, Kazuhito Kawata, Sakura Yamamura, Koji Sawada, Tatsuji Maeshiro, Hiroshi Tobita, Yuichi Yoshida, Masafumi Naito, Asuka Araki, Shingo Arakaki, Takumi Kawaguchi, Hidenao Noritake, Masafumi Ono, Tsutomu Masaki, Satoshi Yasuda, Eiichi Tomita, Masato Yoneda, Norifumi Kawada, Akihiro Tokushige, Yoshihiro Kamada, Hirokazu Takahashi, Shinichiro Ueda, Shinichi Aishima, Yoshio Sumida, Atsushi Nakajima, Takeshi Okanoue

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association　Vol. 21　No. 2　p. 370-379　2022/01/17　Research paper (scientific journal)

Clinical practice advice on lifestyle modification in the management of nonalcoholic fatty liver disease in Japan: an expert review.

Yoshihiro Kamada, Hirokazu Takahashi, Masahito Shimizu, Takumi Kawaguchi, Yoshio Sumida, Hideki Fujii, Yuya Seko, Shinya Fukunishi, Katsutoshi Tokushige, Atsushi Nakajima, Takeshi Okanoue

Journal of gastroenterology　Vol. 56　No. 12　p. 1045-1061　2021/10/31　Research paper (scientific journal)

Serum Desmosterol Level Reflects Hepatic Inflammation Grade in Patients with Biopsy-Confirmed Metabolic Dysfunction-Associated Steatotic Liver Disease.

Takashi Omatsu, Masahiro Koseki, Kaori Ito, Ayami Saga, Hiroshi Sawabe, Katsunao Tanaka, Hiroyasu Inui, Takeshi Okada, Makoto Nishida, Hirokazu Takahashi, Shinichi Aishima, Yoshihiro Kamada, Hiroshi Yoshida, Yasushi Sakata

Journal of atherosclerosis and thrombosis　2025/07/16　Research paper (scientific journal)

Utilizing Altmetrics to Track Advancements in Noninvasive Tests for MASLD.

Masato Yoneda, Yoshio Sumida, Yoshihiro Kamada, Hirokazu Takahashi, Hideki Fujii, Shinichi Takeda, Azadeh Hosseini-Tabatabaei, Atsushi Nakajima

Hepatology research : the official journal of the Japan Society of Hepatology　2025/06/17　Research paper (scientific journal)

Tips for Hepatologist Referral of Patients with Metabolic Dysfunction-Associated Steatotic Liver Disease with Alanine Aminotransferase Levels ≤ 30 U/L

Miwa Kawanaka, Hideki Fujii, Michihiro Iwaki, Hideki Hayashi, Hidenori Toyoda, Satoshi Oeda, Hideyuki Hyogo, Asahiro Morishita, Kensuke Munekage, Kazuhito Kawata, Tsubasa Tsutsumi, Koji Sawada, Tatsuji Maeshiro, Hiroshi Tobita, Yuichi Yoshida, Masafumi Naito, Asuka Araki, Shingo Arakaki, Takumi Kawaguchi, Hidenao Noritake, Masafumi Ono, Tsutomu Masaki, Satoshi Yasuda, Eiichi Tomita, Masato Yoneda, Akihiro Tokushige, Yoshihiro Kamada, Hirokazu Takahashi, Shinichiro Ueda, Shinichi Aishima, Ken Nishino, Katsunori Ishii, Takashi Fushimi, Hirofumi Kawamoto, Yoshio Sumida, Takeshi Okanoue, Atsushi Nakajima, Japan Study Group of Nonalcoholic Fatty Liver Disease (JSG-NAFLD)

Diagnostics　2025/06　Research paper (scientific journal)

Low HDL cholesterol levels in women and hypertriglyceridemia in men: predictors of MASLD onset in individuals without steatosis.

Tsubasa Tsutsumi, Takumi Kawaguchi, Hideki Fujii, Yoshihiro Kamada, Yuichiro Suzuki, Koji Sawada, Miwa Tatsuta, Tatsuji Maeshiro, Hiroshi Tobita, Takemi Akahane, Chitomi Hasebe, Miwa Kawanaka, Takaomi Kessoku, Yuichiro Eguchi, Hayashi Syokita, Atsushi Nakajima, Tomoari Kamada, Hitoshi Yoshiji, Hiroshi Sakugawa, Asahiro Morishita, Tsutomu Masaki, Takumi Ohmura, Toshio Watanabe, Yoshioki Yoda, Nobuyuki Enomoto, Masafumi Ono, Kanako Fuyama, Kazufumi Okada, Naoki Nishimoto, Yoichi M Ito, Hirokazu Takahashi, Michael R Charlton, Mary E Rinella, Yoshio Sumida

Journal of gastroenterology　2025/03/18　Research paper (scientific journal)

Alcohol Intake and Cardiometabolic Risk Factors Are Independently Associated With a Higher AST/Platelet Ratio Index in Obese Males

Hideki Fujii, Yoshihiro Kamada, Yuichiro Suzuki, Koji Sawada, Miwa Tatsuta, Tatsuji Maeshiro, Hiroshi Tobita, Tsubasa Tsutsumi, Takemi Akahane, Chitomi Hasebe, Miwa Kawanaka, Takaomi Kessoku, Yuichiro Eguchi, Hayashi Syokita, Atsushi Nakajima, Tomoari Kamada, Hitoshi Yoshiji, Takumi Kawaguchi, Hiroshi Sakugawa, Asahiro Morishita, Tsutomu Masaki, Takumi Ohmura, Toshio Watanabe, Yoshioki Yoda, Nobuyuki Enomoto, Masafumi Ono, Kanako Fuyama, Kazufumi Okada, Naoki Nishimoto, Yoichi M. Ito, Hirokazu Takahashi, Yoshio Sumida, Japan Study Group of Nonalcoholic Fatty Liver Disease (JSG‐NAFLD)

Liver International Communications　2025/03　Research paper (scientific journal)

Invasion of pancreatic ductal epithelial cells by Enterococcus faecalis is mediated by fibronectin and enterococcal fibronectin-binding protein A

Munefumi Shimosaka, Jumpei Kondo, Mamika Sonoda, Rui Kawaguchi, Emika Noda, Kaho Nishikori, Asuka Ogata, Shinji Takamatsu, Ken Sasai, Hirofumi Akita, Hidetoshi Eguchi, Yoshihiro Kamada, Shigefumi Okamoto, Eiji Miyoshi

Scientific Reports　Vol. 15　No. 1　2025/01/20　Research paper (scientific journal)

Prediction of Advanced Fibrosis in Metabolic Dysfunction-Associated Steatotic Liver Disease by Type IV Collagen 7S.

Hiroshi Ishiba, Yoshio Sumida, Yoshihiro Kamada, Hideki Fujii, Michihiro Iwaki, Hideki Hayashi, Hidenori Toyoda, Satoshi Oeda, Hideyuki Hyogo, Miwa Kawanaka, Asahiro Morishita, Kensuke Munekage, Kazuhito Kawata, Tsubasa Tsutsumi, Koji Sawada, Tatsuji Maeshiro, Hiroshi Tobita, Yuichi Yoshida, Masafumi Naito, Asuka Araki, Shingo Arakaki, Takumi Kawaguchi, Hidenao Noritake, Masafumi Ono, Tsutomu Masaki, Satoshi Yasuda, Eiichi Tomita, Masato Yoneda, Akihiro Tokushige, Hirokazu Takahashi, Shinichiro Ueda, Shinichi Aishima, Atsushi Nakajima, Takeshi Okanoue

Gastro hep advances　Vol. 4　No. 7　p. 100668-100668　2025　Research paper (scientific journal)

Accuracy of type IV collagen 7S versus Enhanced Liver Fibrosis score for diagnosing fibrosis in patients with metabolic dysfunction-associated steatotic liver disease.

Hiroshi Ishiba, Hideki Fujii, Yoshihiro Kamada, Yoshio Sumida, Hirokazu Takahashi, Yuya Seko, Hidenori Toyoda, Hideki Hayashi, Kanji Yamaguchi, Michihiro Iwaki, Masato Yoneda, Taeang Arai, Toshihide Shima, Asahiro Morishita, Kazuhito Kawata, Kengo Tomita, Miwa Kawanaka, Yuichi Yoshida, Tadashi Ikegami, Kazuo Notsumata, Satoshi Oeda, Hideaki Fukushima, Eiji Miyoshi, Shinichi Aishima, Yoshito Itoh, Takeshi Okanoue, Atsushi Nakajima

Hepatology communications　Vol. 9　No. 1　2025/01/01　Research paper (scientific journal)

Quantitative color analysis of the diets of patients with metabolic dysfunction‐associated steatotic liver disease: Comparative study with nutritionally balanced diets

Asumi Yamazaki, Yuka Takachi, Hirokazu Takahashi, Nagisa Hara, Yuji Ogawa, Hideyuki Hyogo, Masahiro Koseki, Mariko Hayakawa, Atsushi Nakajima, Michihiro Iwaki, Makoto Fujii, Takayuki Ishida, Yoshihiro Kamada

Hepatology Research　2024/12/12　Research paper (scientific journal)

Utility of Mac-2 binding protein glycosylation isomer as an excellent biomarker for the prediction of liver fibrosis, activity, and hepatocellular carcinoma onset: an expert review.

Yoshihiro Kamada, Yoshio Sumida, Hirokazu Takahashi, Hideki Fujii, Eiji Miyoshi, Atsushi Nakajima

Journal of gastroenterology　2024/12/09　Research paper (scientific journal)

Generation and validation of antibody 42B1 recognizing galactose-deficient IgG for diagnosis of chronic inflammatory diseases.

Naoki Morishima, Maki Iwaisako, Yoshihiro Kamada, Miyako Nakano, Masafumi Shiida, Tatsuya Ono, Reika Sonoda, Risa Uemura, Daisuke Sakon, Munefumi Shimosaka, Shinji Takamatsu, Jumpei Kondo, Takeo Yoshihara, Shinichiro Shinzaki, Eiji Mita, Tetsuo Takehara, Takashi Kumada, Makoto Yamada, Eiji Miyoshi

Clinica chimica acta; international journal of clinical chemistry　Vol. 566　p. 120052-120052　2024/11/16　Research paper (scientific journal)

Development of a FUT8 Inhibitor with Cellular Inhibitory Properties

Yoshiyuki Manabe, Tomoyuki Takebe, Satomi Kasahara, Koki Hizume, Kazuya Kabayama, Yoshihiro Kamada, Akiko Asakura, Shinichiro Shinzaki, Shinji Takamatsu, Eiji Miyoshi, Ana García-García, Sergey Y. Vakhrushev, Ramón Hurtado-Guerrero, Koichi Fukase

Angewandte Chemie International Edition　2024/09/28　Research paper (scientific journal)

Core-fucose-specific Pholiota squarrosa lectin decreased hepatic inflammatory macrophage infiltration in steatohepatitis mice.

Yoshihiro Kamada, Yui Ueda, Eriko Matsuno, Riku Matsumoto, Maaya Akita, Shinji Takamatsu, Eiji Miyoshi

Glycoconjugate journal　2024/09/09　Research paper (scientific journal)

Clinical characteristics of steatotic liver disease categories in a large cohort of Japanese health checkup participants

Yoshihiro Kamada, Hideki Fujii, Yuichiro Suzuki, Koji Sawada, Miwa Tatsuta, Tatsuji Maeshiro, Hiroshi Tobita, Tsubasa Tsutsumi, Takemi Akahane, Chitomi Hasebe, Miwa Kawanaka, Takaomi Kessoku, Yuichiro Eguchi, Hayashi Syokita, Atsushi Nakajima, Tomoari Kamada, Hitoshi Yoshiji, Takumi Kawaguchi, Hiroshi Sakugawa, Asahiro Morishita, Tsutomu Masaki, Takumi Ohmura, Toshio Watanabe, Yoshioki Yoda, Nobuyuki Enomoto, Masafumi Ono, Kanako Fuyama, Kazufumi Okada, Naoki Nishimoto, Yoichi M. Ito, Hirokazu Takahashi, Yoshio Sumida

Gastro Hep Advances　2024/08　Research paper (scientific journal)

Is liver fibrosis more advanced in MetALD than in MASLD?

Hideki Fujii, Yoshihiro Kamada, Akihiro Tokushige, Toshio Watanabe, Norifumi Kawada

Journal of hepatology　2024/07/29

Severe hepatic steatosis promotes increased liver stiffness in the early stages of metabolic dysfunction-associated steatotic liver disease.

Takashi Kumada, Hidenori Toyoda, Sadanobu Ogawa, Tatsuya Gotoh, Yasuaki Suzuki, Katsutoshi Sugimoto, Yuichi Yoshida, Hidekatsu Kuroda, Yoshihiro Kamada, Yoshio Sumida, Takanori Ito, Tomoyuki Akita, Junko Tanaka

Liver international : official journal of the International Association for the Study of the Liver　Vol. 44　No. 7　p. 1700-1714　2024/07　Research paper (scientific journal)

Systematic Strategy for the Development of Glycosyltransferase Inhibitors: Diversity-Oriented Synthesis of FUT8 Inhibitors

Yoshiyuki Manabe, Koki Hizume, Yohei Takakura, Shinji Takamatsu, Eiji Miyoshi, Yoshihiro Kamada, Ramón Hurtado-Guerrero, Koichi Fukase

Synlett　Vol. 35　No. 11　p. 1273-1278　2024/06/14　Research paper (scientific journal)

Serum levels of the N-terminal fragment of connective tissue growth factor is a novel biomarker for chronic pancreatitis.

Naoki Morishima, Yoshihiro Kamada, Hiyori Ota, Yoshifumi Iwagami, Hidenori Takahashi, Munefumi Shimosaka, Daisuke Sakon, Jumpei Kondo, Makoto Yamada, Takashi Kumada, Hidetoshi Eguchi, Eiji Miyoshi

Practical laboratory medicine　Vol. 40　2024/05　Research paper (scientific journal)

Validation study of age-independent fibrosis score (Fibrosis-3 index) in patients with metabolic dysfunction-associated steatotic liver disease.

Kazuhiro Nouso, Miwa Kawanaka, Hideki Fujii, Kazuya Kariyama, Hidenori Toyoda, Michihiro Iwaki, Hideki Hayashi, Satoshi Oeda, Hideyuki Hyogo, Asahiro Morishita, Kensuke Munekage, Kazuhito Kawata, Tsubasa Tsutsumi, Koji Sawada, Tatsuji Maeshiro, Hiroshi Tobita, Yuichi Yoshida, Masafumi Naito, Asuka Araki, Shingo Arakaki, Takumi Kawaguchi, Hidenao Noritake, Masafumi Ono, Tsutomu Masaki, Satoshi Yasuda, Eiichi Tomita, Masato Yoneda, Akihiro Tokushige, Yoshihiro Kamada, Hirokazu Takahashi, Shinichiro Ueda, Shinichi Aishima, Yoshio Sumida, Atsushi Nakajima, Takashi Kumada, Takeshi Okanoue

Hepatology research : the official journal of the Japan Society of Hepatology　2024/04/25　Research paper (scientific journal)

Hepatic inflammation and fibrosis are profiles related to mid-term mortality in biopsy-proven MASLD: A multicenter study in Japan.

Tsubasa Tsutsumi, Takumi Kawaguchi, Hideki Fujii, Yoshihiro Kamada, Hirokazu Takahashi, Miwa Kawanaka, Yoshio Sumida, Michihiro Iwaki, Hideki Hayashi, Hidenori Toyoda, Satoshi Oeda, Hideyuki Hyogo, Asahiro Morishita, Kensuke Munekage, Kazuhito Kawata, Koji Sawada, Tatsuji Maeshiro, Hiroshi Tobita, Yuichi Yoshida, Masafumi Naito, Asuka Araki, Shingo Arakaki, Hidenao Noritake, Masafumi Ono, Tsutomu Masaki, Satoshi Yasuda, Eiichi Tomita, Masato Yoneda, Akihiro Tokushige, Shinichiro Ueda, Shinichi Aishima, Atsushi Nakajima, Takeshi Okanoue

Alimentary pharmacology & therapeutics　2024/04/23　Research paper (scientific journal)

Accuracy of the Enhanced Liver Fibrosis Test in Patients With Type 2 Diabetes Mellitus and Its Clinical Implications.

Taeang Arai, Hirokazu Takahashi, Yuya Seko, Hidenori Toyoda, Hideki Hayashi, Kanji Yamaguchi, Michihiro Iwaki, Masato Yoneda, Toshihide Shima, Hideki Fujii, Asahiro Morishita, Kazuhito Kawata, Kengo Tomita, Miwa Kawanaka, Yuichi Yoshida, Tadashi Ikegami, Kazuo Notsumata, Satoshi Oeda, Masanori Atsukawa, Yoshihiro Kamada, Yoshio Sumida, Hideaki Fukushima, Eiji Miyoshi, Shinichi Aishima, Takeshi Okanoue, Yoshito Itoh, Atsushi Nakajima

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association　Vol. 22　No. 4　p. 789-797　2024/04　Research paper (scientific journal)

Prognosis of biopsy-confirmed metabolic dysfunction- associated steatotic liver disease: A sub-analysis of the CLIONE study.

Michihiro Iwaki, Hideki Fujii, Hideki Hayashi, Hidenori Toyoda, Satoshi Oeda, Hideyuki Hyogo, Miwa Kawanaka, Asahiro Morishita, Kensuke Munekage, Kazuhito Kawata, Tsubasa Tsutsumi, Koji Sawada, Tatsuji Maeshiro, Hiroshi Tobita, Yuichi Yoshida, Masafumi Naito, Asuka Araki, Shingo Arakaki, Takumi Kawaguchi, Hidenao Noritake, Masafumi Ono, Tsutomu Masaki, Satoshi Yasuda, Eiichi Tomita, Masato Yoneda, Akihiro Tokushige, Yoshihiro Kamada, Hirokazu Takahashi, Shinichiro Ueda, Shinichi Aishima, Yoshio Sumida, Atsushi Nakajima, Takeshi Okanoue

Clinical and molecular hepatology　Vol. 30　No. 2　p. 225-234　2024/04　Research paper (scientific journal)

Correspondence on Letter regarding "Prognosis of biopsy-confirmed MASLD: A sub-analysis of the CLIONE study".

Hideki Fujii, Michihiro Iwaki, Yoshihiro Kamada

Clinical and molecular hepatology　Vol. 30　No. 2　p. 281-283　2024/04　Research paper (scientific journal)

iATT liver fat quantification for steatosis grading by referring to MRI proton density fat fraction: a multicenter study.

Masashi Hirooka, Sadanobu Ogawa, Yohei Koizumi, Yuichi Yoshida, Tatsuya Goto, Satoshi Yasuda, Masahiro Yamahira, Tsutomu Tamai, Ryoko Kuromatsu, Toshihisa Matsuzaki, Tomoyuki Suehiro, Yoshihiro Kamada, Yoshio Sumida, Yoichi Hiasa, Hidenori Toyoda, Takashi Kumada

Journal of gastroenterology　2024/03/30　Research paper (scientific journal)

Diagnostic performance of shear wave measurement in the detection of hepatic fibrosis: A multicenter prospective study.

Takashi Kumada, Hidenori Toyoda, Sadanobu Ogawa, Tatsuya Gotoh, Yuichi Yoshida, Masahiro Yamahira, Masashi Hirooka, Yohei Koizumi, Yoichi Hiasa, Tsutomu Tamai, Ryoko Kuromatsu, Toshihisa Matsuzaki, Tomoyuki Suehiro, Yoshihiro Kamada, Yoshio Sumida, Junko Tanaka, Masahito Shimizu

Hepatology research : the official journal of the Japan Society of Hepatology　2024/02/13　Research paper (scientific journal)

Serum Cytokeratin 18 Fragment Is an Indicator for Treating Metabolic Dysfunction-Associated Steatotic Liver Disease.

Miwa Kawanaka, Yoshihiro Kamada, Hirokazu Takahashi, Michihiro Iwaki, Ken Nishino, Wenli Zhao, Yuya Seko, Masato Yoneda, Yoshihito Kubotsu, Hideki Fujii, Yoshio Sumida, Hirofumi Kawamoto, Yoshito Itoh, Atsushi Nakajima

Gastro hep advances　Vol. 3　No. 8　p. 1120-1128　2024　Research paper (scientific journal)

Tofogliflozin attenuates renal lipid deposition and inflammation <i>via</i> PPARα upregulation mediated by miR-21a impairment in diet-induced steatohepatitic mice

Sae Nishihara, Masahiro Koseki, Katsunao Tanaka, Takashi Omatsu, Ayami Saga, Hiroshi Sawabe, Hiroyasu Inui, Takeshi Okada, Tohru Ohama, Daisuke Okuzaki, Yoshihiro Kamada, Masafumi Ono, Makoto Nishida, Mikio Watanabe, Yasushi Sakata

Endocrine Journal　2024　Research paper (scientific journal)

Identification of clinical phenotypes associated with poor prognosis in patients with nonalcoholic fatty liver disease via unsupervised machine learning.

Takanori Ito, Hikaru Morooka, Hirokazu Takahashi, Hideki Fujii, Michihiro Iwaki, Hideki Hayashi, Hidenori Toyoda, Satoshi Oeda, Hideyuki Hyogo, Miwa Kawanaka, Asahiro Morishita, Kensuke Munekage, Kazuhito Kawata, Tsubasa Tsutsumi, Koji Sawada, Tatsuji Maeshiro, Hiroshi Tobita, Yuichi Yoshida, Masafumi Naito, Asuka Araki, Shingo Arakaki, Takumi Kawaguchi, Hidenao Noritake, Masafumi Ono, Tsutomu Masaki, Satoshi Yasuda, Eiichi Tomita, Masato Yoneda, Akihiro Tokushige, Masatoshi Ishigami, Yoshihiro Kamada, Shinichiro Ueda, Shinichi Aishima, Yoshio Sumida, Atsushi Nakajima, Takeshi Okanoue

Journal of gastroenterology and hepatology　Vol. 38　No. 10　p. 1832-1839　2023/08/19　Research paper (scientific journal)

Prevalence and associated metabolic factors of nonalcoholic fatty liver disease in the general population from 2014 to 2018 in Japan: A large-scale multicenter retrospective study.

Hideki Fujii, Yuichiro Suzuki, Koji Sawada, Miwa Tatsuta, Tatsuji Maeshiro, Hiroshi Tobita, Tsubasa Tsutsumi, Takemi Akahane, Chitomi Hasebe, Miwa Kawanaka, Takaomi Kessoku, Yuichiro Eguchi, Hayashi Syokita, Atsushi Nakajima, Tomoari Kamada, Hitoshi Yoshiji, Takumi Kawaguchi, Hiroshi Sakugawa, Asahiro Morishita, Tsutomu Masaki, Takumi Ohmura, Toshio Watanabe, Norifumi Kawada, Yoshioki Yoda, Nobuyuki Enomoto, Masafumi Ono, Kanako Fuyama, Kazufumi Okada, Naoki Nishimoto, Yoichi M Ito, Yoshihiro Kamada, Hirokazu Takahashi, Yoshio Sumida, Japan Study Group Of Nonalcoholic Fatty Liver Disease Jsg-Nafld

Hepatology research : the official journal of the Japan Society of Hepatology　Vol. 53　No. 11　p. 1059-1072　2023/08/03　Research paper (scientific journal)

Reconsidering low HDL-cholesterol levels as a predictive factor for the development of hepatocellular carcinoma

Hideki Fujii, Hirokazu Takahashi, Yoshihiro Kamada, Yoshio Sumida, Atsushi Nakajima

JHEP Reports　Vol. 5　No. 8　p. 100752-100752　2023/08　Research paper (scientific journal)

Prediction of Liver-Related Events With a Combination of Liver Stiffness Measurements and Controlled Attenuation Parameters in Japanese Patients With Biopsy-Proven Non-alcoholic Fatty Liver Disease.

Hideki Hayashi, Yoshihiro Kamada, Hideki Fujii, Hirokazu Takahashi, Satoshi Oeda, Michihiro Iwaki, Takumi Kawaguchi, Eiichi Tomita, Masato Yoneda, Akihiro Tokushige, Shinichiro Ueda, Shinichi Aishima, Yoshio Sumida, Atsushi Nakajima, Takeshi Okanoue

Ultrasound in medicine & biology　Vol. 49　No. 7　p. 1658-1664　2023/07　Research paper (scientific journal)

Agile 3+ and Agile 4, noninvasive tests for liver fibrosis, are excellent formulae to predict liver-related events in nonalcoholic fatty liver disease.

Kouichi Miura, Hideki Hayashi, Yoshihiro Kamada, Hideki Fujii, Hirokazu Takahashi, Satoshi Oeda, Michihiro Iwaki, Takumi Kawaguchi, Eiichi Tomita, Masato Yoneda, Akihiro Tokushige, Shinichiro Ueda, Shinichi Aishima, Yoshio Sumida, Atsushi Nakajima, Takeshi Okanoue

Hepatology research : the official journal of the Japan Society of Hepatology　Vol. 53　No. 10　p. 978-988　2023/06/23　Research paper (scientific journal)

Prohaptoglobin is a possible prognostic biomarker for colorectal cancer.

Koichi Morishita, Jumpei Kondo, Daisuke Sakon, Ayumu Hayashibara, Ikumi Tamura, Kayoko Shimizu, Shinji Takamatsu, Kohei Murata, Yoshihiro Kamada, Eiji Miyoshi

Biochemical and biophysical research communications　Vol. 672　p. 72-80　2023/06/09　Research paper (scientific journal)

動脈硬化のリスク因子としての脂肪肝炎 CLIONE試験から学ぶ日本人におけるNAFLDと心血管疾患の特徴

藤井 英樹, 鎌田 佳宏, 川中 美和, 高橋 宏和, 角田 圭雄, 中島 淳

日本動脈硬化学会総会プログラム・抄録集　Vol. 55回　p. 166-166　2023/06

Validation of the utility of Agile scores to identify advanced fibrosis and cirrhosis in Japanese patients with nonalcoholic fatty liver disease.

Satoshi Oeda, Yuya Seko, Hideki Hayashi, Taeang Arai, Michihiro Iwaki, Masato Yoneda, Toshihide Shima, Kazuo Notsumata, Tadashi Ikegami, Hideki Fujii, Hidenori Toyoda, Kouichi Miura, Asahiro Morishita, Kazuhito Kawata, Kengo Tomita, Miwa Kawanaka, Hiroshi Isoda, Kanji Yamaguchi, Hideaki Fukushima, Yoshihiro Kamada, Yoshio Sumida, Shinichi Aishima, Yoshito Itoh, Takeshi Okanoue, Atsushi Nakajima, Hirokazu Takahashi

Hepatology research : the official journal of the Japan Society of Hepatology　Vol. 53　No. 6　p. 489-496　2023/06　Research paper (scientific journal)

Association of Serum Albumin Levels and Long-Term Prognosis in Patients with Biopsy-Confirmed Nonalcoholic Fatty Liver Disease.

Hirokazu Takahashi, Miwa Kawanaka, Hideki Fujii, Michihiro Iwaki, Hideki Hayashi, Hidenori Toyoda, Satoshi Oeda, Hideyuki Hyogo, Asahiro Morishita, Kensuke Munekage, Kazuhito Kawata, Tsubasa Tsutsumi, Koji Sawada, Tatsuji Maeshiro, Hiroshi Tobita, Yuichi Yoshida, Masafumi Naito, Asuka Araki, Shingo Arakaki, Takumi Kawaguchi, Hidenao Noritake, Masafumi Ono, Tsutomu Masaki, Satoshi Yasuda, Eiichi Tomita, Masato Yoneda, Akihiro Tokushige, Yoshihiro Kamada, Shinichiro Ueda, Shinichi Aishima, Yoshio Sumida, Atsushi Nakajima, Takeshi Okanoue, Japan Study Group Of Nonalcoholic Fatty Liver Disease Jsg-Nafld

Nutrients　Vol. 15　No. 9　2023/04/22　Research paper (scientific journal)

エラストグラフィ(肝・膵領域) 日本人におけるAgile scoreの有用性の検討

大枝 敏, 林 秀樹, 米田 正人, 島 俊英, 豊田 秀徳, 鎌田 佳宏, 高橋 宏和, 中島 淳

超音波医学　Vol. 50　No. Suppl.　p. S214-S214　2023/04

肝疾患における画像診断の進歩 FibroScanのLSMおよびCAPを用いたNAFLD患者の肝関連イベント予測 多施設共同研究

林 秀樹, 鎌田 佳宏, 藤井 英樹

肝臓　Vol. 64　No. Suppl.1　p. A150-A150　2023/04

【肝線維化とバイオマーカー】肝線維化マーカーのスコアリングシステム

角田 圭雄, 鎌田 佳宏, 藤井 英樹

医学のあゆみ　Vol. 284　No. 12　p. 951-955　2023/03

Noninvasive tests predict liver-related events and mortality in patients with non-alcoholic fatty liver disease: sub-analysis of the CLIONE-Asia study.

Hiroshi Ishiba, Yoshio Sumida, Yoshihiro Kamada, Hideki Fujii, Michihiro Iwaki, Hideki Hayashi, Hidenori Toyoda, Satoshi Oeda, Hideyuki Hyogo, Miwa Kawanaka, Asahiro Morishita, Kensuke Munekage, Kazuhito Kawata, Tsubasa Tsutsumi, Koji Sawada, Tatsuji Maeshiro, Hiroshi Tobita, Yuichi Yoshida, Masafumi Naito, Asuka Araki, Shingo Arakaki, Takumi Kawaguchi, Hidenao Noritake, Masafumi Ono, Tsutomu Masaki, Satoshi Yasuda, Eiichi Tomita, Masato Yoneda, Akihiro Tokushige, Hirokazu Takahashi, Shinichiro Ueda, Shinichi Aishima, Atsushi Nakajima, Takeshi Okanoue

Journal of gastroenterology and hepatology　Vol. 38　No. 6　p. 896-904　2023/02/16　Research paper (scientific journal)

Twin research shows glycan changes are more susceptible to environmental factors than their carrier glycoproteins.

Tatsuya Asuka, Yoshihiro Kamada, Koichi Morishita, Tomoya Fukuoka, Shinji Takamatsu, Jumpei Kondo, Mikio Watanabe, Norio Sakai, Kazuo Hayakawa, Eiji Miyoshi

Glycoconjugate journal　2023/02/14　Research paper (scientific journal)

A multicenter, retrospective, cohort study shows platelet counts predict HCC development in patients with NAFLD.

Hideki Fujii, Makoto Fujii, Michihiro Iwaki, Hideki Hayashi, Hidenori Toyoda, Satoshi Oeda, Hideyuki Hyogo, Miwa Kawanaka, Asahiro Morishita, Kensuke Munekage, Kazuhito Kawata, Tsubasa Tsutsumi, Koji Sawada, Tatsuji Maeshiro, Hiroshi Tobita, Yuichi Yoshida, Masafumi Naito, Asuka Araki, Shingo Arakaki, Takumi Kawaguchi, Hidenao Noritake, Masafumi Ono, Tsutomu Masaki, Satoshi Yasuda, Eiichi Tomita, Masato Yoneda, Norifumi Kawada, Akihiro Tokushige, Yoshihiro Kamada, Hirokazu Takahashi, Shinichiro Ueda, Shinichi Aishima, Yoshio Sumida, Atsushi Nakajima, Takeshi Okanoue

Hepatology research : the official journal of the Japan Society of Hepatology　Vol. 53　No. 5　p. 391-400　2023/01/27　Research paper (scientific journal)

Validation of Noninvasive Markers for HCC Risk Stratification in 1389 Patients With Biopsy-proven NAFLD.

Hidenori Toyoda, Hideki Fujii, Michihiro Iwaki, Hideki Hayashi, Satoshi Oeda, Hideyuki Hyogo, Miwa Kawanaka, Asahiro Morishita, Kensuke Munekage, Kazuhito Kawata, Sakura Yamamura, Koji Sawada, Tatsuji Maeshiro, Hiroshi Tobita, Yuichi Yoshida, Masafumi Naito, Asuka Araki, Shingo Arakaki, Takumi Kawaguchi, Hidenao Noritake, Masafumi Ono, Tsutomu Masaki, Satoshi Yasuda, Eiichi Tomita, Masato Yoneda, Norifumi Kawada, Akihiro Tokushige, Yoshihiro Kamada, Hirokazu Takahashi, Shinichiro Ueda, Shinichi Aishima, Yoshio Sumida, Atsushi Nakajima, Takeshi Okanoue

Gastro hep advances　Vol. 2　No. 8　p. 1093-1102　2023　Research paper (scientific journal)

The FIB-4 Index Predicts the Development of Liver-Related Events, Extrahepatic Cancers, and Coronary Vascular Disease in Patients with NAFLD.

Yoshihiro Kamada, Kensuke Munekage, Takashi Nakahara, Hideki Fujii, Yoshiyuki Sawai, Yoshinori Doi, Hideyuki Hyogo, Yoshio Sumida, Yasuharu Imai, Eiji Miyoshi, Masafumi Ono

Nutrients　Vol. 15　No. 1　2022/12/23　Research paper (scientific journal)

Diagnostic accuracy of enhanced liver fibrosis test for nonalcoholic steatohepatitis-related fibrosis: Multicenter study.

Yuya Seko, Hirokazu Takahashi, Hidenori Toyoda, Hideki Hayashi, Kanji Yamaguchi, Michihiro Iwaki, Masato Yoneda, Taeang Arai, Toshihide Shima, Hideki Fujii, Asahiro Morishita, Kazuhito Kawata, Kengo Tomita, Miwa Kawanaka, Yuichi Yoshida, Tadashi Ikegami, Kazuo Notsumata, Satoshi Oeda, Yoshihiro Kamada, Yoshio Sumida, Hideaki Fukushima, Eiji Miyoshi, Shinichi Aishima, Takeshi Okanoue, Atsushi Nakajima, Yoshito Itoh

Hepatology research : the official journal of the Japan Society of Hepatology　Vol. 53　No. 4　p. 312-321　2022/12/16　Research paper (scientific journal)

A Dietary Oxysterol, 7-Ketocholesterol, Exacerbates Imiquimod-Induced Psoriasis-like Dermatitis inSteatohepatitic Mice

Ayami Saga, Masahiro Koseki, Kotaro Kanno, Jiuyang Chang, Tomoaki Higo, Daisuke Okuzaki, Takeshi Okada, Hiroyasu Inui, Masumi Asaji, Katsunao Tanaka, Takashi Omatsu, Sae Nishihara, Yinghong Zhu, Kaori Ito, Hiroaki Hattori, Ikuyo Ichi, Yoshihiro Kamada, Masafumi Ono, Toshiji Saibara, Tohru Ohama, Shungo Hikoso, Makoto Nishida, Shizuya Yamashita, Yasushi Sakata

International Journal of Molecular Sciences　Vol. 23　No. 24　p. 15855-15855　2022/12/13　Research paper (scientific journal)

Age-dependent effects of diabetes and obesity on liver-related events in nonalcoholic fatty liver disease: Subanalysis of CLIONE in Asia.

Yuya Seko, Miwa Kawanaka, Hideki Fujii, Michihiro Iwaki, Hideki Hayashi, Hidenori Toyoda, Satoshi Oeda, Hideyuki Hyogo, Asahiro Morishita, Kensuke Munekage, Kazuhito Kawata, Sakura Yamamura, Koji Sawada, Tatsuji Maeshiro, Hiroshi Tobita, Yuichi Yoshida, Masafumi Naito, Asuka Araki, Shingo Arakaki, Takumi Kawaguchi, Hidenao Noritake, Masafumi Ono, Tsutomu Masaki, Satoshi Yasuda, Eiichi Tomita, Masato Yoneda, Akihiro Tokushige, Yoshihiro Kamada, Hirokazu Takahashi, Shinichiro Ueda, Shinichi Aishima, Yoshio Sumida, Takeshi Okanoue, Yoshito Itoh, Atsushi Nakajima

Journal of gastroenterology and hepatology　Vol. 37　No. 12　p. 2313-2320　2022/10/05　Research paper (scientific journal)

NASHの本態に迫る 血小板数によるNAFLD患者の予後予測 全国多施設共同研究

藤井 英樹, 高橋 宏和, 鎌田 佳宏

肝臓　Vol. 63　No. Suppl.2　p. A501-A501　2022/09

Lewis glycosphingolipids as critical determinants of TRAIL sensitivity in cancer cells

Tomoya Fukuoka, Kenta Moriwaki, Shinji Takamatsu, Jumpei Kondo, Miki Tanaka-Okamoto, Azusa Tomioka, Manami Semba, Sachiko Komazawa-Sakon, Yoshihiro Kamada, Hiroyuki Kaji, Yasuhide Miyamoto, Masahiro Inoue, Kazuhiko Bessho, Yoko Miyoshi, Keiichi Ozono, Hiroyasu Nakano, Eiji Miyoshi

Oncogene　Vol. 41　No. 38　p. 4385-4396　2022/08/15　Research paper (scientific journal)

NAFLDにおいてFIB-4 indexは肝疾患関連イベントおよび肝疾患関連死の予測に有用である CLIONE-ASIA試験のサブ解析

石破 博, 角田 圭雄, 藤井 英樹, 高橋 宏和, 鎌田 佳宏

人間ドック　Vol. 37　No. 2　p. 346-346　2022/08　Research paper (other academic)

門脈圧亢進症の病態と診断 肝生検施行NAFLD患者における全死亡ならびに肝関連合併症発生予測の試み

藤井 英樹, 鎌田 佳宏, 角田 圭雄, 高橋 宏和

日本門脈圧亢進症学会雑誌　Vol. 28　No. 3　p. 78-78　2022/08　Research paper (other academic)

【ウイルス肝炎制御時代の肝発癌】ウイルス肝炎制御をめぐる疫学と最新動向 わが国におけるNAFLD/NASHの疫学

角田 圭雄, 藤井 英樹, 高橋 宏和, 鎌田 佳宏, 川口 巧, 中島 淳

臨床消化器内科　Vol. 37　No. 8　p. 880-887　2022/07

ペマフィブラートは脂肪肝炎関連心筋症モデルにおいてNLRP3インフラマソームの活性化を抑制する(Pemafibrate Suppresses NLRP3 Inflammasome Activation in a Novel Model of Cholesterol-induced, Steatohepatitis-related Cardiomyopathy)

冠野 昂太郎, 小関 正博, 常 久洋, 嵯峨 礼美, 乾 洋勉, 岡田 健志, 田中 克尚, 朝治 真澄, 朱 穎こう, 井手 盛子, 肥後 友彰, 齋藤 茂芳, 奥崎 大介, 大濱 透, 西田 誠, 鎌田 佳宏, 小野 正文, 西原 利治, 山下 静也, 坂田 泰史

日本循環器学会学術集会抄録集　Vol. 86回　p. PJ03-1　2022/03

Whole-exome Sequencing Analysis of a Japanese Patient With Hyperinsulinemia and Liver Dysfunction.

Shingo Fujita, Emi Horitani, Yohei Miyashita, Yukari Fujita, Kenji Fukui, Yoshihiro Kamada, Ikuo Mineo, Yoshihiro Asano, Hiromi Iwahashi, Junji Kozawa, Iichiro Shimomura

Journal of the Endocrine Society　Vol. 6　No. 3　2022/03/01

Pemafibrate suppresses NLRP3 inflammasome activation in the liver and heart in a novel mouse model of steatohepatitis-related cardiomyopathy.

Kotaro Kanno, Masahiro Koseki, Jiuyang Chang, Ayami Saga, Hiroyasu Inui, Takeshi Okada, Katsunao Tanaka, Masumi Asaji, Yinghong Zhu, Seiko Ide, Shigeyoshi Saito, Tomoaki Higo, Daisuke Okuzaki, Tohru Ohama, Makoto Nishida, Yoshihiro Kamada, Masafumi Ono, Toshiji Saibara, Shizuya Yamashita, Yasushi Sakata

Scientific reports　Vol. 12　No. 1　p. 2996-2996　2022/02/22　Research paper (scientific journal)

Lifestyle changes during the coronavirus disease 2019 pandemic impact metabolic dysfunction-associated fatty liver disease.

Hideki Fujii, Naotoshi Nakamura, Shinya Fukumoto, Tatsuo Kimura, Akemi Nakano, Yuji Nadatani, Yukie Tauchi, Yuuko Nishii, Shingo Takashima, Yoshihiro Kamada, Toshio Watanabe, Norifumi Kawada

Liver international : official journal of the International Association for the Study of the Liver　Vol. 42　No. 5　p. 995-1004　2022/01/07　Research paper (scientific journal)

Fucosylated haptoglobin is a novel predictive marker of hepatocellular carcinoma after hepatitis C virus elimination in patients with advanced liver fibrosis.

Kumiko Shirai, Hayato Hikita, Ryotaro Sakamori, Akira Doi, Yuki Tahata, Sadatsugu Sakane, Yoshihiro Kamada, Kazuhiro Murai, Akira Nishio, Ryoko Yamada, Takahiro Kodama, Yasutoshi Nozaki, Naruyasu Kakita, Hisashi Ishida, Fumihiko Nakanishi, Naoki Morishita, Kazuho Imanaka, Mitsuru Sakakibara, Tomohide Tatsumi, Eiji Miyoshi, Tetsuo Takehara

PloS one　Vol. 17　No. 12　2022　Research paper (scientific journal)

Enterococcus spp. have higher fitness for survival, in a pH-dependent manner, in pancreatic juice among duodenal bacterial flora.

Saki Itoyama, Emika Noda, Shinji Takamatsu, Jumpei Kondo, Rui Kawaguchi, Munefumi Shimosaka, Tomoya Fukuoka, Daisuke Motooka, Shota Nakamura, Masahiro Tanemura, Suguru Mitsufuji, Yoshifumi Iwagami, Hirofumi Akita, Toru Tobe, Yoshihiro Kamada, Hidetoshi Eguchi, Eiji Miyoshi

JGH open : an open access journal of gastroenterology and hepatology　Vol. 6　No. 1　p. 85-90　2022/01　Research paper (scientific journal)

Evidence-based clinical practice guidelines for nonalcoholic fatty liver disease/nonalcoholic steatohepatitis 2020.

Katsutoshi Tokushige, Kenichi Ikejima, Masafumi Ono, Yuichiro Eguchi, Yoshihiro Kamada, Yoshito Itoh, Norio Akuta, Masato Yoneda, Motoh Iwasa, Masashi Yoneda, Motoyuki Otsuka, Nobuharu Tamaki, Tomomi Kogiso, Hiroto Miwa, Kazuaki Chayama, Nobuyuki Enomoto, Tooru Shimosegawa, Tetsuo Takehara, Kazuhiko Koike

Journal of gastroenterology　Vol. 56　No. 11　p. 951-963　2021/11　Research paper (scientific journal)

Evidence-based clinical practice guidelines for nonalcoholic fatty liver disease/nonalcoholic steatohepatitis 2020.

Katsutoshi Tokushige, Kenichi Ikejima, Masafumi Ono, Yuichiro Eguchi, Yoshihiro Kamada, Yoshito Itoh, Norio Akuta, Masato Yoneda, Motoh Iwasa, Masashi Yoneda, Motoyuki Otsuka, Nobuharu Tamaki, Tomomi Kogiso, Hiroto Miwa, Kazuaki Chayama, Nobuyuki Enomoto, Tooru Shimosegawa, Tetsuo Takehara, Kazuhiko Koike

Hepatology research : the official journal of the Japan Society of Hepatology　Vol. 51　No. 10　p. 1013-1025　2021/10　Research paper (scientific journal)

The scaffold-dependent function of RIPK1 in dendritic cells promotes injury-induced colitis.

Kenta Moriwaki, Christa Park, Kazuha Koyama, Sakthi Balaji, Kohei Kita, Ryoko Yagi, Sachiko Komazawa-Sakon, Manami Semba, Tatsuya Asuka, Hiroyasu Nakano, Yoshihiro Kamada, Eiji Miyoshi, Francis K M Chan

Mucosal immunology　Vol. 15　No. 1　p. 84-95　2021/08/30　Research paper (scientific journal)

Diet-induced hepatic steatosis and fibrosis were improved by a selective ppara modulator, pemafibrate, in STZ -induced diabetic mice

J. Chang, M. Koseki, K. Kanno, A. Saga, T. Okada, K. Tanaka, Y. Kamada, T. Higo, D. Okuzaki, H. Inui, M. Asaji, Y. Zhu, T. Ohama, M. Nishida, S. Yamashita, Y. Sakata

Atherosclerosis　Vol. 331　p. e173-e173　2021/08　Research paper (scientific journal)

Rifaximin ameliorates intestinal inflammation in cirrhotic patients with hepatic encephalopathy.

Yasuyuki Tamai, Motoh Iwasa, Akiko Eguchi, Ryuta Shigefuku, Yoshihiro Kamada, Eiji Miyoshi, Yoshiyuki Takei

JGH open : an open access journal of gastroenterology and hepatology　Vol. 5　No. 7　p. 827-830　2021/07　Research paper (scientific journal)

脂肪肝炎惹起食により誘導した脂肪肝炎モデルにおける心筋症の合併と、脂肪肝炎/心筋障害に対するペマフィブラートの有効性

小関 正博, 冠野 昂太郎, 常 久洋, 嵯峨 礼美, 鎌田 佳宏, 岡田 健志, 田中 克尚, 乾 洋勉, 大濱 透, 西田 誠, 坂田 泰史, 齋藤 茂芳

糖尿病　Vol. 64　No. Suppl.1　p. LDP-3　2021/05

超音波検査による脂肪膵診断は不顕性慢性膵炎発症予測に有用である

鎌田 佳宏, 藤井 誠, 大野 ゆう子, 三善 英知

超音波医学　Vol. 48　No. Suppl.　p. S731-S731　2021/04

選択的PPARaモジュレーターであるペマフィブラートはSTZ誘発糖尿病マウスを用いた食餌誘発性脂肪肝炎モデルにおいて肝線維化および心筋炎症を抑制する(A Selective PPARa Modulator, Pemafibrate Reduced Hepatic Fibrosis and Cardiac Inflammation in Cholesterol-Dominant, Atherogenic-Diet Induced Steatohepatitis Model in STZ Induced Diabetic Mice)

Chang Jiuyang, Koseki Masahiro, Saga Ayami, Kanno Kotaro, Tanaka Katsunao, Okada Takeshi, Saito Shigeyoshi, Kamada Yoshihiro, Inui Hiroyasu, Asaji Masumi, Zhu Yinghong, Ohama Tohru, Nishida Makoto, Yamashita Shizuya, Sakata Yasushi

日本循環器学会学術集会抄録集　Vol. 85回　p. I-4　2021/03

FIB-4 First in the Diagnostic Algorithm of Metabolic-Dysfunction-Associated Fatty Liver Disease in the Era of the Global Metabodemic.

Yoshio Sumida, Masashi Yoneda, Katsutoshi Tokushige, Miwa Kawanaka, Hideki Fujii, Masato Yoneda, Kento Imajo, Hirokazu Takahashi, Yuichiro Eguchi, Masafumi Ono, Yuichi Nozaki, Hideyuki Hyogo, Masahiro Koseki, Yuichi Yoshida, Takumi Kawaguchi, Yoshihiro Kamada, Takeshi Okanoue, Atsushi Nakajima, Japan Study Group Of Nafld Jsg-Nafld

Life (Basel, Switzerland)　Vol. 11　No. 2　2021/02/14　Research paper (scientific journal)

Identification of fucosylated haptoglobin-producing cells in pancreatic cancer tissue and its molecular mechanism.

Nami Ito, Momoko Yamada, Koichi Morishita, Satoshi Nojima, Kei Motooka, Natsumi Sakata, Tatsuya Asuka, Ryoji Otsu, Shinji Takamatsu, Yoshihiro Kamada, Soichiro Mori, Hirofumi Akita, Hidetoshi Eguchi, Eiichi Morii, Eiji Miyoshi

Glycoconjugate journal　Vol. 38　No. 1　p. 45-54　2021/02/01　Research paper (scientific journal)

Eradication of hepatitis C virus with direct-acting antivirals improves glycemic control in diabetes: A multicenter study.

Hirokazu Takahashi, Takashi Nakahara, Tomomi Kogiso, Kento Imajo, Takaomi Kessoku, Takumi Kawaguchi, Tatsuya Ide, Miwa Kawanaka, Hideyuki Hyogo, Hideki Fujii, Masafumi Ono, Yoshihiro Kamada, Yoshio Sumida, Keizo Anzai, Masahito Shimizu, Takuji Torimura, Atsushi Nakajima, Katsutoshi Tokushige, Kazuaki Chayama, Yuichiro Eguchi

JGH open : an open access journal of gastroenterology and hepatology　Vol. 5　No. 2　p. 228-234　2021/02　Research paper (scientific journal)

Detection of fucosylated haptoglobin using the 10-7G antibody as a biomarker for evaluating endoscopic remission in ulcerative colitis.

Kei Motooka, Koichi Morishita, Nami Ito, Shinichiro Shinzaki, Taku Tashiro, Satoshi Nojima, Kayoko Shimizu, Mutsuhiro Date, Natsumi Sakata, Momoko Yamada, Shinji Takamatsu, Yoshihiro Kamada, Hideki Iijima, Tsunekazu Mizushima, Eiichi Morii, Tetsuo Takehara, Eiji Miyoshi

World journal of gastroenterology　Vol. 27　No. 2　p. 162-175　2021/01/14　Research paper (scientific journal)

Glycan Biomarkers in Pancreatic Cancer

Miyoshi, E., Morishita, K., Asuka, T., Fukuoka, T., Takamatsu, S., Kamada, Y., Nakano, M.

Comprehensive Glycoscience: Second Edition　2021　Research paper (scientific journal)

The role of RIPK1 kinase activity in the progression of mouse steatohepatitis

Yoshihiro Kamada

Cancer Science　2021　Research paper (scientific journal)

Identification of characteristic oligosaccharide structures and molecular mechanisms that regulate TRAIL sensitivity

Yoshihiro Kamada

Cancer Science　2021　Research paper (scientific journal)

Over-expression of a precursor of haptoglobin induces epithelial-mesenchymal transition in human HCT116 cells

Yoshihiro Kamada

Cancer Science　2021　Research paper (scientific journal)

Molecular mechanisms of Mac-2bp secretion in fatty liver diseases and cancer cell lines

Yoshihiro Kamada

Cancer Science　2021　Research paper (scientific journal)

Inflammation during Lung Cancer Progression and Ethyl Pyruvate Treatment Observed by Pulmonary Functional Hyperpolarized 129Xe MRI in Mice.

Atsuomi Kimura, Seiya Utsumi, Akihiro Shimokawa, Renya Nishimori, Neil J Stewart, Yoshihiro Kamada, Hirohiko Imai, Hideaki Fujiwara

Contrast media & molecular imaging　Vol. 2021　p. 9918702-9918702　2021　Research paper (scientific journal)

Transcriptomics Identify Thrombospondin-2 as a Biomarker for NASH and Advanced Liver Fibrosis

Kazuhiro Kozumi, Takahiro Kodama, Hiroki Murai, Sadatsugu Sakane, Olivier Govaere, Simon Cockell, Daisuke Motooka, Naruyasu Kakita, Yukinori Yamada, Yasuteru Kondo, Yuki Tahata, Ryoko Yamada, Hayato Hikita, Ryotaro Sakamori, Yoshihiro Kamada, Ann K. Daly, Quentin M. Anstee, Tomohide Tatsumi, Eiichi Morii, Tetsuo Takehara

Hepatology　Vol. 74　No. 5　p. 2452-2466　2021　Research paper (scientific journal)

次世代型糖鎖抗体10-7G mAbが捉える血中プロハプトグロビンは、炎症性腸疾患の新しい病態診断バイオマーカーとなる

本岡 渓, 森下 康一, 伊藤 菜美, 新崎 信一郎, 田代 拓, 坂田 菜摘, 山田 桃子, 高松 真二, 鎌田 佳宏, 竹原 徹郎, 三善 英知

日本分子腫瘍マーカー研究会誌　Vol. 36　p. 13-14　2021

Immunometabolic disorder in cardiovascular system and liver mediated by long-term exposure to diet-derived oxidized cholesterol, 7-ketocholesterol

M. Koseki, K. Kanno, A. Saga, J. Chang, H. Inui, T. Okada, T. Ohama, M. Nishida, Y. Kamada, E. Miyoshi, S. Yamashita, Y. Sakata

Atherosclerosis　Vol. 315　p. e223-e223　2020/12　Research paper (scientific journal)

TRAIL感受性を制御する糖鎖構造とその分子メカニズムの同定

福岡 智哉, 森脇 健太, 小松 未稀, 野田 愛美香, 高松 真二, 鎌田 佳宏, 近藤 純平, 井上 正宏, 三善 英知

日本癌学会総会記事　Vol. 79回　p. OJ17-8　2020/10

次世代型糖鎖抗体10-7G mAbが捉える血中プロハプトグロビンは、炎症性腸疾患の新しい病態診断バイオマーカーとなる

本岡 渓, 森下 康一, 伊藤 菜美, 新崎 信一郎, 田代 拓, 坂田 菜摘, 山田 桃子, 高松 真二, 鎌田 佳宏, 竹原 徹郎, 三善 英知

日本分子腫瘍マーカー研究会プログラム・講演抄録　Vol. 40回　p. 50-51　2020/09

膵がん微小環境におけるプロハプトグロビン産生機序の検討

伊藤 菜美, 森下 康一, 本岡 渓, 坂田 菜摘, 山田 桃子, 高松 真二, 鎌田 佳宏, 森 総一郎, 秋田 裕史, 江口 英利, 野島 聡, 森井 英一, 三善 英知

膵臓　Vol. 35　No. 3　p. A327-A327　2020/07

脂質代謝研究の進歩 NAFLD/NASH、動脈硬化進展における外因性酸化ステロール7-ketocholesterolの影響

小関 正博, 冠野 昂太郎, 常 久洋, 嵯峨 礼美, 岡田 健志, 鎌田 佳宏, 山下 静也, 坂田 泰史

日本動脈硬化学会総会プログラム・抄録集　Vol. 52回　p. 124-124　2020/07

心血管疾患のリスク病態としてのNAFLD/NASH 動脈硬化惹起食誘導脂肪肝炎モデルにおける、ペマフィブラートの抗脂肪肝炎、抗心筋炎症作用の解明

小関 正博, 冠野 昂太郎, 常 久洋, 嵯峨 礼美, 岡田 健志, 鎌田 佳宏, 山下 静也, 坂田 泰史

日本動脈硬化学会総会プログラム・抄録集　Vol. 52回　p. 157-157　2020/07

食餌誘発性脂肪肝炎マウスモデルにおいて7-ketocholesterolはイミキモド誘導乾癬様皮膚炎を増悪させる

嵯峨 礼美, 小関 正博, 冠野 昂太郎, 常 久洋, 朝治 真澄, 岡田 健志, 鎌田 佳宏, 乾 洋勉, 朱 穎こう, 大濱 透, 西田 誠, 山下 静也, 坂田 泰史

日本動脈硬化学会総会プログラム・抄録集　Vol. 52回　p. 280-280　2020/07

脂質代謝研究の進歩 NAFLD/NASH、動脈硬化進展における外因性酸化ステロール7-ketocholesterolの影響

小関 正博, 冠野 昂太郎, 常 久洋, 嵯峨 礼美, 岡田 健志, 鎌田 佳宏, 山下 静也, 坂田 泰史

日本動脈硬化学会総会プログラム・抄録集　Vol. 52回　p. 124-124　2020/07

心血管疾患のリスク病態としてのNAFLD/NASH 動脈硬化惹起食誘導脂肪肝炎モデルにおける、ペマフィブラートの抗脂肪肝炎、抗心筋炎症作用の解明

小関 正博, 冠野 昂太郎, 常 久洋, 嵯峨 礼美, 岡田 健志, 鎌田 佳宏, 山下 静也, 坂田 泰史

日本動脈硬化学会総会プログラム・抄録集　Vol. 52回　p. 157-157　2020/07

食餌誘発性脂肪肝炎マウスモデルにおいて7-ketocholesterolはイミキモド誘導乾癬様皮膚炎を増悪させる

嵯峨 礼美, 小関 正博, 冠野 昂太郎, 常 久洋, 朝治 真澄, 岡田 健志, 鎌田 佳宏, 乾 洋勉, 朱 穎こう, 大濱 透, 西田 誠, 山下 静也, 坂田 泰史

日本動脈硬化学会総会プログラム・抄録集　Vol. 52回　p. 280-280　2020/07

Loss of core fucosylation reduces low-density lipoprotein receptor expression in hepatocytes by inducing PCSK9 production.

Yoshihiro Kamada, Akiko Yamamoto, Anna Fujiyoshi, Masahiro Koseki, Koichi Morishita, Tatsuya Asuka, Shinji Takamatsu, Yasushi Sakata, Tetsuo Takehara, Naoyuki Taniguchi, Eiji Miyoshi

Biochemical and biophysical research communications　Vol. 527　No. 3　p. 682-688　2020/06/30　Research paper (scientific journal)

Serum Mac-2 Binding Protein Levels Associate with Metabolic Parameters and Predict Liver Fibrosis Progression in Subjects with Fatty Liver Disease: A 7-Year Longitudinal Study.

Yoshihiro Kamada, Koichi Morishita, Masahiro Koseki, Mayu Nishida, Tatsuya Asuka, Yukiko Naito, Makoto Yamada, Shinji Takamatsu, Yasushi Sakata, Tetsuo Takehara, Eiji Miyoshi

Nutrients　Vol. 12　No. 6　2020/06/12　Research paper (scientific journal)

Loss of Rab6a in the small intestine causes lipid accumulation and epithelial cell death from lactation.

Ayano Iwaki, Kenta Moriwaki, Tomoaki Sobajima, Manabu Taniguchi, Shin-Ichiro Yoshimura, Masataka Kunii, Satoshi Kanda, Yoshihiro Kamada, Eiji Miyoshi, Akihiro Harada

FASEB journal : official publication of the Federation of American Societies for Experimental Biology　Vol. 34　No. 7　p. 9450-9465　2020/06/04　Research paper (scientific journal)

【NAFLD/NASHの進歩と新たな展開】最新の治療薬・治験薬の状況

角田 圭雄, 徳重 克年, 川中 美和, 藤井 英樹, 米田 正人, 今城 健人, 高橋 宏和, 江口 有一郎, 小野 正文, 野崎 雄一, 兵庫 秀幸, 小関 正博, 吉田 雄一, 川口 巧, 鎌田 佳宏, 中島 淳

消化器・肝臓内科　Vol. 7　No. 5　p. 438-445　2020/05

食事由来7-ketocholesterolは、Ldl受容体欠損マウスにおいて、脂肪肝炎とアテローム性動脈硬化症を増悪させる

冠野 昂太郎, 小関 正博, 嵯峨 礼美, 常久 洋, 岡田 健志, 乾 洋勉, 朝治 真澄, 朱 穎こう, 大濱 透, 鎌田 佳宏, 西田 誠, 山下 静也, 坂田 泰史

脂質生化学研究　Vol. 62　p. 161-161　2020/05

食餌誘導性脂肪肝炎マウスモデルにおいて7-ketocholesterolは乾癬様皮膚炎を促進させる

嵯峨 礼美, 小関 正博, 冠野 昂太郎, 常久 洋, 朝治 真澄, 岡田 健志, 鎌田 佳宏, 乾 洋勉, 朱 穎こう, 大濱 透, 西田 誠, 山下 静也, 坂田 泰史

脂質生化学研究　Vol. 62　p. 163-163　2020/05

血清7-ketocholesterol濃度は7年後の肝機能異常を予測する

小関 正博, 鎌田 佳宏, 冠野 昂太郎, 常久 洋, 嵯峨 礼美, 岡田 健志, 乾 洋勉, 大濱 透, 西田 誠, 三善 英知, 山下 静也, 坂田 泰史

脂質生化学研究　Vol. 62　p. 165-165　2020/05

食餌誘導性肝線維化モデルにおけるペマフィブラートの肝臓,心臓への作用メカニズムの解明

小関 正博, 冠野 昂太郎, 常 久洋, 嵯峨 礼美, 岡田 健志, 乾 洋勉, 齋藤 茂芳, 鎌田 佳宏, 山下 静也, 坂田 泰史

肝臓　Vol. 61　No. Suppl.1　p. A303-A303　2020/04

食餌誘導性肝線維化モデルにおけるペマフィブラートの肝臓,心臓への作用メカニズムの解明

小関 正博, 冠野 昂太郎, 常 久洋, 嵯峨 礼美, 岡田 健志, 乾 洋勉, 齋藤 茂芳, 鎌田 佳宏, 山下 静也, 坂田 泰史

肝臓　Vol. 61　No. Suppl.1　p. A303-A303　2020/04

Identification of the epitope of 10-7G glycan antibody to recognize cancer-associated haptoglobin.

Koichi Morishita, Yuta Maki, Shinji Takamatsu, Nami Ito, Sayaka Koda, Kei Motooka, Yoshihiro Kamada, Yasuhiro Kajihara, Eiji Miyoshi

Analytical biochemistry　Vol. 593　p. 113588-113588　2020/03/15　Research paper (scientific journal)

Antidiabetic Therapy in the Treatment of Nonalcoholic Steatohepatitis.

Yoshio Sumida, Masashi Yoneda, Katsutoshi Tokushige, Miwa Kawanaka, Hideki Fujii, Masato Yoneda, Kento Imajo, Hirokazu Takahashi, Yuichiro Eguchi, Masafumi Ono, Yuichi Nozaki, Hideyuki Hyogo, Masahiro Koseki, Yuichi Yoshida, Takumi Kawaguchi, Yoshihiro Kamada, Takeshi Okanoue, Atsushi Nakajima, Japan Study Group Of Nafld Jsg-Nafld

International journal of molecular sciences　Vol. 21　No. 6　2020/03/11　Research paper (scientific journal)

Hepatoprotective Effect of SGLT2 Inhibitor on Nonalcoholic Fatty Liver Disease

Sumida Y, Yoneda M, Tokushige K, Kawanaka M, Fujii H, Yoneda M, Imajo K, Takahashi H, Ono M, Nozaki Y, Hyogo H, Koseki M, Yoshida Y, Kawaguchi T, Kamada Y, Eguchi Y, Okanoue T, Nakajima A

SGLT2 inhibitors　Vol. 2　No. S1　p. 17-25　2020/03/05　Research paper (scientific journal)

Dietary Oxysterol, 7-Ketocholesterol Accelerates Hepatic Lipid Accumulation and Macrophage Infiltration in Obese Mice.

Jiuyang Chang, Masahiro Koseki, Ayami Saga, Kotaro Kanno, Tomoaki Higo, Daisuke Okuzaki, Takeshi Okada, Hiroyasu Inui, Katsunao Tanaka, Masumi Asaji, Yinghong Zhu, Yoshihiro Kamada, Masafumi Ono, Toshiji Saibara, Ikuyo Ichi, Tohru Ohama, Makoto Nishida, Shizuya Yamashita, Yasushi Sakata

Frontiers in endocrinology　Vol. 11　p. 614692-614692　2020　Research paper (scientific journal)

Functional glycomics: Application to medical science and hepatology

Yoshihiro Kamada

Hepatology Research　Vol. 50　No. 2　2020　Research paper (scientific journal)

Forkhead Box M1 Transcription Factor Drives Liver Inflammation Linking to Hepatocarcinogenesis in Mice.

Tomohide Kurahashi, Yuichi Yoshida, Satoshi Ogura, Mayumi Egawa, Kunimaro Furuta, Hayato Hikita, Takahiro Kodama, Ryotaro Sakamori, Shinichi Kiso, Yoshihiro Kamada, I-Ching Wang, Hidetoshi Eguchi, Eiichi Morii, Yuichiro Doki, Masaki Mori, Vladimir V Kalinichenko, Tomohide Tatsumi, Tetsuo Takehara

Cellular and molecular gastroenterology and hepatology　Vol. 9　No. 3　p. 425-446　2020　Research paper (scientific journal)

Liver-specific deletion of Ngly1 causes abnormal nuclear morphology and lipid metabolism under food stress

Yoshihiro Kamada

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease　Vol. 1866　No. 3　2020　Research paper (scientific journal)

The Core Fucose on an IgG Antibody is an Endogenous Ligand of Dectin-1.

Yoshiyuki Manabe, Roberta Marchetti, Yohei Takakura, Masahiro Nagasaki, Wataru Nihei, Tomoyuki Takebe, Katsunori Tanaka, Kazuya Kabayama, Fabrizio Chiodo, Shinya Hanashima, Yoshihiro Kamada, Eiji Miyoshi, Hari Prasad Dulal, Yoshiki Yamaguchi, Yoshiyuki Adachi, Naohito Ohno, Hiroshi Tanaka, Alba Silipo, Koichi Fukase, Antonio Molinaro

Angewandte Chemie (International ed. in English)　Vol. 58　No. 51　p. 18697-18702　2019/12/16　Research paper (scientific journal)

NASH/脂肪肝から発生する肝細胞癌でも腫瘍マーカーは上昇するか【陽性率はウイルス性肝炎由来の肝細胞癌とよく似ている】

三善 英知, 鎌田 佳宏

日本医事新報　No. 4991　p. 54-55　2019/12

【NAFLD/NASH診療の現在地】NAFLD/NASHの病態と成因

鎌田 佳宏, 三善 英知, 竹原 徹郎

消化器の臨床　Vol. 22　No. 4　p. 271-277　2019/11

Clinical features of hepatocellular carcinoma in nonalcoholic fatty liver disease patients without advanced fibrosis.

Kazuhisa Kodama, Takumi Kawaguchi, Hideyuki Hyogo, Tomoaki Nakajima, Masafumi Ono, Masataka Seike, Hirokazu Takahashi, Yuichi Nozaki, Miwa Kawanaka, Saiyu Tanaka, Kento Imajo, Yoshio Sumida, Yoshihiro Kamada, Hideki Fujii, Yuya Seko, Tetsuo Takehara, Yoshito Itoh, Atsushi Nakajima, Naohiko Masaki, Takuji Torimura, Toshiji Saibara, Yoshiyasu Karino, Kazuaki Chayama, Katsutoshi Tokushige

Journal of gastroenterology and hepatology　Vol. 34　No. 9　p. 1626-1632　2019/09　Research paper (scientific journal)

Establishment and characterization of a fucosylated α-fetoprotein-specific monoclonal antibody: a potential application for clinical research.

Yuriko Egashira, Masatoshi Suganuma, Yukiko Kataoka, Yukiko Higa, Nobuyuki Ide, Koichi Morishita, Yoshihiro Kamada, Jianguo Gu, Koji Fukagawa, Eiji Miyoshi

Scientific reports　Vol. 9　No. 1　p. 12359-12359　2019/08/26　Research paper (scientific journal)

心血管疾患のリスク病態としてのNAFLD/NASH NAFLD/NASH進展における外因性酸化ステロールの影響の検討

小関 正博, 鎌田 佳宏, 小野 正文, 嵯峨 礼美, 冠野 昂太郎, 常 久洋, 乾 洋勉, 岡田 健志, 大濱 透, 西田 誠, 山田 眞, 三善 英知, 坂田 泰史, 山下 静也, 西原 利治

日本動脈硬化学会総会プログラム・抄録集　Vol. 51回　p. GS1-5　2019/07

膵がん患者血中で増加するプロハプトグロビン産生細胞の同定とその生物学的機能の解析

伊藤 菜美, 森下 康一, 糸山 幸来, 高松 真二, 鎌田 佳宏, 森 総一郎, 秋田 裕史, 江口 英利, 野島 聡, 森井 英一, 三善 英知

膵臓　Vol. 34　No. 3　p. A218-A219　2019/06

膵がん特異的なMac-2bpに対する次世代型糖鎖抗体の作成とその生物学的意義

西野 晋輔, 桝田 実花, 池田 瞬, 高松 真二, 鎌田 佳宏, 江口 英利, 三善 英知

膵臓　Vol. 34　No. 3　p. A218-A218　2019/06

Laboratory tests in liver diseases

Sumida Y, Kamada Y, Iwai M, Kwo PY, Yoneda M

Diagnosis of Liver Diseases 2nd edition　p. 19-34　2019/06

高インスリン血症と反応性低血糖を呈し,全エクソーム解析を行った1例

堀谷 恵美, 藤田 真吾, 宮下 洋平, 黒田 陽平, 藤田 有可里, 細川 吉弥, 木村 武量, 徳永 あゆみ, 福井 健司, 小澤 純二, 朝野 仁裕, 鎌田 佳宏, 嶺尾 郁夫, 岩橋 博見, 下村 伊一郎

糖尿病　Vol. 62　No. Suppl.1　p. S-157　2019/04

Core fucose is essential glycosylation for CD14-dependent Toll-like receptor 4 and Toll-like receptor 2 signalling in macrophages.

Kotarosumitomo Nakayama, Kana Wakamatsu, Hironobu Fujii, Shinichiro Shinzaki, Shinji Takamatsu, Shinobu Kitazume, Yoshihiro Kamada, Tetsuo Takehara, Naoyuki Taniguchi, Eiji Miyoshi

Journal of biochemistry　Vol. 165　No. 3　p. 227-237　2019/03/01　Research paper (scientific journal)

Impact of fatty pancreas and lifestyle on the development of subclinical chronic pancreatitis in healthy people undergoing a medical checkup.

Makoto Fujii, Yuko Ohno, Makoto Yamada, Yoshihiro Kamada, Eiji Miyoshi

Environmental health and preventive medicine　Vol. 24　No. 1　p. 10-10　2019/02/07　Research paper (scientific journal)

Possible involvement of Enterococcus infection in the pathogenesis of chronic pancreatitis and cancer.

Tomohiro Maekawa, Risako Fukaya, Shinji Takamatsu, Saki Itoyama, Tomoya Fukuoka, Makoto Yamada, Tomoki Hata, Satoshi Nagaoka, Koichi Kawamoto, Hidetoshi Eguchi, Kohei Murata, Takashi Kumada, Toshifumi Ito, Masahiro Tanemura, Kahoko Fujimoto, Yasuhiko Tomita, Toru Tobe, Yoshihiro Kamada, Eiji Miyoshi

Biochemical and biophysical research communications　Vol. 506　No. 4　p. 962-969　2018/12/02　Research paper (scientific journal)

Haptoglobin phenotype is a critical factor in the use of fucosylated haptoglobin for pancreatic cancer diagnosis.

Koichi Morishita, Nami Ito, Sayaka Koda, Megumi Maeda, Kotarosumitomo Nakayama, Kiyoshi Yoshida, Shinji Takamatsu, Makoto Yamada, Hidetoshi Eguchi, Yoshihiro Kamada, Eiji Miyoshi

Clinica chimica acta; international journal of clinical chemistry　Vol. 487　p. 84-89　2018/12　Research paper (scientific journal)

A Data Mining-based Prognostic Algorithm for NAFLD-related Hepatoma Patients: A Nationwide Study by the Japan Study Group of NAFLD.

Kawaguchi T, Tokushige K, Hyogo H, Aikata H, Nakajima T, Ono M, Kawanaka M, Sawada K, Imajo K, Honda K, Takahashi H, Mori K, Tanaka S, Seko Y, Nozaki Y, Kamada Y, Fujii H, Kawaguchi A, Takehara T, Yanase M, Sumida Y, Eguchi Y, Seike M, Yoneda M, Suzuki Y, Saibara T, Karino Y, Chayama K, Hashimoto E, George J, Torimura T

Scientific reports　Vol. 8　No. 1　p. 10434-10434　2018/07　Research paper (scientific journal)

Targeting the mevalonate pathway is a novel therapeutic approach to inhibit oncogenic FoxM1 transcription factor in human hepatocellular carcinoma.

Satoshi Ogura, Yuichi Yoshida, Tomohide Kurahashi, Mayumi Egawa, Kunimaro Furuta, Shinichi Kiso, Yoshihiro Kamada, Hayato Hikita, Hidetoshi Eguchi, Hisakazu Ogita, Yuichiro Doki, Masaki Mori, Tomohide Tatsumi, Tetsuo Takehara

Oncotarget　Vol. 9　No. 30　p. 21022-21035　2018/04/20　Research paper (scientific journal)

Establishment of an antibody specific for cancer-associated haptoglobin: a possible implication of clinical investigation.

Kimihiro Nishino, Sayaka Koda, Naoya Kataoka, Shinji Takamatsu, Miyako Nakano, Shun Ikeda, Yuka Kamamatsu, Koichi Morishita, Kenta Moriwaki, Hidetoshi Eguchi, Eiko Yamamoto, Fumitaka Kikkawa, Yasuhiko Tomita, Yoshihiro Kamada, Eiji Miyoshi

Oncotarget　Vol. 9　No. 16　p. 12732-12744　2018/02/27　Research paper (scientific journal)

肥満の及ぼす人体への影響～特にアディポサイトカイン～

鎌田佳宏, 三善英知, 竹原徹郎

消化器・肝臓内科　2018/02

A possible involvement of pancreatic juice-associated bacteria in the pathogenesis of chronic pancreatitis and cancer

Yoshihiro Kamada

Cancer Science　2018　Research paper (scientific journal)

Loss of core-fucosylation in immortalized hepatocytes increased alpha 3 beta 1 integrin in extracellular vesicles

Yoshihiro Kamada

Cancer Science　2018　Research paper (scientific journal)

Fucosylated haptoglobin determined by a novel glycan antibody is an innovative biomarker for pancreatic cancer

Yoshihiro Kamada

Cancer Science　2018　Research paper (scientific journal)

Hepatocyte-specific overexpression of FoxM1 transcription factor leads to spontaneous liver inflammation, fibrosis, and tumorigenesis in mice

Yoshihiro Kamada

Journal of Hepatology　2018　Research paper (scientific journal)

Haptoglobin phenotype is a critical factor for evaluating serum fucosylated haptoglobin as a cancer biomarker

Yoshihiro Kamada

Cancer Science　2018　Research paper (scientific journal)

Involvement of Enterococcus faecalis in the pathogenesis of pancreatic cancer

Yoshihiro Kamada

Cancer Science　2018　Research paper (scientific journal)

A novel antibody for Mac-2 binding protein, 19-8H mAb can recognize tumor-associated macrophages

Yoshihiro Kamada

Cancer Science　2018　Research paper (scientific journal)

Serum Wisteria floribunda agglutinin-positive Mac-2-binding protein levels and liver fibrosis: A meta-analysis

Kiyoaki Ito, Kenta Murotani, Yukiomi Nakade, Tadahisa Inoue, Haruhisa Nakao, Yoshio Sumida, Yoshihiro Kamada, Masashi Yoneda

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY　Vol. 32　No. 12　p. 1922-1930　2017/12　Research paper (scientific journal)

Fatty Acid-Mediated Stromal Reprogramming of Pancreatic Stellate Cells Induces Inflammation and Fibrosis That Fuels Pancreatic Cancer

Tomoki Hata, Koichi Kawamoto, Hidetoshi Eguchi, Yoshihiro Kamada, Shinji Takamatsu, Tomohiro Maekawa, Satoshi Nagaoka, Daisaku Yamada, Yoshifumi Iwagami, Tadafumi Asaoka, Takehiro Noda, Hiroshi Wada, Kunihito Gotoh, Atsushi Masamune, Eiji Miyoshi, Masaki Mori, Yuichiro Doki

PANCREAS　Vol. 46　No. 10　p. 1259-1266　2017/11　Research paper (scientific journal)

Use of Mac-2 binding protein as a biomarker for nonalcoholic fatty liver disease diagnosis.

Yoshihiro Kamada, Masafumi Ono, Hideyuki Hyogo, Hideki Fujii, Yoshio Sumida, Makoto Yamada, Kojiroh Mori, Saiyu Tanaka, Tomohiro Maekawa, Yusuke Ebisutani, Akiko Yamamoto, Shinji Takamatsu, Masashi Yoneda, Norifumi Kawada, Kazuaki Chayama, Toshiji Saibara, Tetsuo Takehara, Eiji Miyoshi

Hepatology communications　Vol. 1　No. 8　p. 780-791　2017/10　Research paper (scientific journal)

Increased expression of Forkhead box M1 transcription factor is associated with clinicopathological features and confers a poor prognosis in human hepatocellular carcinoma.

Mayumi Egawa, Yuichi Yoshida, Satoshi Ogura, Tomohide Kurahashi, Takashi Kizu, Kunimaro Furuta, Yoshihiro Kamada, Norihiro Chatani, Mina Hamano, Shinichi Kiso, Hayato Hikita, Tomohide Tatsumi, Hidetoshi Eguchi, Hiroaki Nagano, Yuichiro Doki, Masaki Mori, Tetsuo Takehara

Hepatology research : the official journal of the Japan Society of Hepatology　Vol. 47　No. 11　p. 1196-1205　2017/10　Research paper (scientific journal)

Reevaluation of Pholiota squarrosa lectin-reactive haptoglobin as a pancreatic cancer biomarker using an improved ELISA system

Ken Kusama, Yuki Okamoto, Keiko Saito, Tsukasa Kasahara, Teizo Murata, Yasushi Ueno, Yuka Kobayashi, Yoshihiro Kamada, Eiji Miyoshi

GLYCOCONJUGATE JOURNAL　Vol. 34　No. 4　p. 537-544　2017/08　Research paper (scientific journal)

Use of Mac-2 binding protein as a biomarker for nonalcoholic fatty liver disease diagnosis.

Kamada Y, Ono M, Hyogo H, Fujii H, Sumida Y, Yamada M, Mori K, Tanaka S, Maekawa T, Ebisutani Y, Yamamoto A, Takamatsu S, Yoneda M, Kawada N, Chayama K, Saibara T, Takehara T, Miyoshi E, Japan Study, Group of, Nonalcoholic Fatty Liver Disease, SG‐NAFLD

Hepatol Communications　2017/08　Research paper (scientific journal)

Establishment of mouse Mac-2 binding protein enzyme-linked immunosorbent assay and its application for mouse chronic liver disease models

Ayumi Iwata, Yoshihiro Kamada, Yusuke Ebisutani, Akiko Yamamoto, Yui Ueda, Hitomi Arai, Hironobu Fujii, Shinji Takamatsu, Nobuhiro Maruyama, Masahiro Maeda, Tetsuo Takehara, Eiji Miyoshi

HEPATOLOGY RESEARCH　Vol. 47　No. 9　p. 902-909　2017/08　Research paper (scientific journal)

Development of alpha 1,6-fucosyltransferase inhibitors through the diversity-oriented syntheses of GDP-fucose mimics using the coupling between alkyne and sulfonyl azide

Yoshiyuki Manabe, Satomi Kasahara, Yohei Takakura, Xiaoxiao Yang, Shinji Takamatsu, Yoshihiro Kamada, Eiji Miyoshi, Daisuke Yoshidome, Koichi Fukase

BIOORGANIC & MEDICINAL CHEMISTRY　Vol. 25　No. 11　p. 2844-2850　2017/06　Research paper (scientific journal)

A novel pathogenesis of inflammatory bowel disease from the perspective of glyco-immunology

Shinichiro Shinzaki, Hideki Iijima, Hironobu Fujii, Yoshihiro Kamada, Tetsuji Naka, Tetsuo Takehara, Eiji Miyoshi

JOURNAL OF BIOCHEMISTRY　Vol. 161　No. 5　p. 409-415　2017/05　Research paper (scientific journal)

[Comprehensive analysis of disease-related glycosylation, leading to glyco-therapy].

Eiji Miyoshi, Hironobu Fujii, Shinichiro Shinzaki, Masahiro Tanemura, Yoshihiro Kamada

Seikagaku. The Journal of Japanese Biochemical Society　Vol. 89　No. 2　p. 264-8　2017/04　Research paper (scientific journal)

Randomized trial of exercise intervention vs. usual care for breast cancer patients with aromatase inhibitor to prevent and improve the aromatase inhibitor induced

Yoshihiro Kamada

Cancer Research　2017　Research paper (scientific journal)

The feasibility of nurse intervention to improve and maintain the BMI of breast cancer survivors over 25 to appropriate levels

Yoshihiro Kamada

Cancer Research　2017　Research paper (scientific journal)

Establishment of mouse Mac-2 binding protein ELISA and its application for mouse chronic liver disease models

Yoshihiro Kamada

Hepatology　2017　Research paper (scientific journal)

A glycoproteomic approach to identify novel glycomarkers for cancer stem cells

Atsuko Sawanobori, Kenta Moriwaki, Shinji Takamatsu, Yoshihiro Kamada, Eiji Miyoshi

PROTEOMICS　Vol. 16　No. 24　p. 3073-3080　2016/12

A glycoproteomic approach to identify novel glycomarkers for cancer stem cells

Atsuko Sawanobori, Kenta Moriwaki, Shinji Takamatsu, Yoshihiro Kamada, Eiji Miyoshi

PROTEOMICS　Vol. 16　No. 24　p. 3073-3080　2016/12

Core-fucosylation plays a pivotal role in hepatitis B pseudo virus infection: a possible implication for HBV glycotherapy

Shinji Takamatsu, Mayuka Shimomura, Yoshihiro Kamada, Haruka Maeda, Tomoaki Sobajima, Hayato Hikita, Masumi Iijima, Yuta Okamoto, Ryo Misaki, Kazuhito Fujiyama, Shushi Nagamori, Yoshikatsu Kanai, Tetsuo Takehara, Keiji Ueda, Shun'ichi Kuroda, Eiji Miyoshi

GLYCOBIOLOGY　Vol. 26　No. 11　p. 1180-1189　2016/11　Research paper (scientific journal)

Hepatic aberrant glycosylation by N-acetylglucosaminyltransferase V accelerates HDL assembly

Yoshihiro Kamada, Sachiho Kida, Ken-ichi Hirano, Satoshi Yamaguchi, Akira Suzuki, Chikako Hashimoto, Akihiro Kimura, Motoya Sato, Hironobu Fujii, Tomoaki Sobajima, Akiko Yamamoto, Yusuke Ebisutani, Shinji Takamatsu, Shinichiro Shinzaki, Yuichi Yoshida, Makoto Yamada, Hironori Nagasaka, Tetsuo Takehara, Eiji Miyoshi

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY　Vol. 311　No. 5　p. G859-G868　2016/11　Research paper (scientific journal)

Roles of Mac-2 binding protein in the NASH liver fibrosis progression

Yusuke Ebisutani, Yoshihiro Kamada, Akiko Yamamoto, Shun Ikeda, Hitomi Arai, Ayumi Iwata, Yui Ueda, Anna Fujiyoshi, Kotone Asada, Mayu Nishida, Hironobu Fujii, Shinji Takamatsu, Masafumi Ono, Hideyuki Hyogo, Hideki Fujii, Yoshio Sumida, Kohjiroh Mori, Saiyu Tanaka, Yuichi Yoshida, Yoshito Itoh, Norifumi Kawada, Kazuaki Chayama, Toshiji Saibara, Tetsuo Takehara, Eiji Miyoshi

HEPATOLOGY　Vol. 64　p. 784A-785A　2016/10　Research paper (scientific journal)

Application of glycoscience to the early detection of pancreatic cancer

Eiji Miyoshi, Yoshihiro Kamada

CANCER SCIENCE　Vol. 107　No. 10　p. 1357-1362　2016/10

Establishment of mouse Mac-2 binding protein enzyme-linked immunosorbent assay and its application for mouse chronic liver disease models.

Iwata A, Kamada Y, Ebisutani Y, Yamamoto A, Ueda Y, Arai H, Fujii H, Takamatsu S, Maruyama N, Maeda M, Takehara T, Miyoshi E

Hepatology Research　2016/09　Research paper (scientific journal)

Application of glycoscience to the early detection of pancreatic cancer

Miyoshi, E., Kamada, Y.

Cancer Science　Vol. 107　No. 10　2016/07　Research paper (scientific journal)

Hepatocellular carcinoma in Japanese patients with nonalcoholic fatty liver disease and alcoholic liver disease: multicenter survey

Katsutoshi Tokushige, Hideyuki Hyogo, Tomoaki Nakajima, Masafumi Ono, Takumi Kawaguchi, Koichi Honda, Yuichiro Eguchi, Yuichi Nozaki, Miwa Kawanaka, Saiyu Tanaka, Kento Imajo, Yoshio Sumida, Yoshihiro Kamada, Hideki Fujii, Yasuaki Suzuki, Tomomi Kogiso, Yoshiyasu Karino, Kensuke Munekage, Ryoko Kuromatsu, Satoshi Oeda, Mikio Yanase, Kohjiro Mori, Yuji Ogawa, Yuya Seko, Tetsuo Takehara, Yoshito Itoh, Atsushi Nakajima, Kazuyuki Kanemasa, Ken Nishino, Naohiko Masaki, Hirokazu Takahashi, Masataka Seike, Takuji Torimura, Toshiji Saibara, Joji Toyota, Kazuaki Chayama, Etsuko Hashimoto

JOURNAL OF GASTROENTEROLOGY　Vol. 51　No. 6　p. 586-596　2016/06　Research paper (scientific journal)

Site-specific and linkage analyses of fucosylated N-glycans on haptoglobin in sera of patients with various types of cancer: possible implication for the differential diagnosis of cancer

Shiro Takahashi, Taiki Sugiyama, Mayuka Shimomura, Yoshihiro Kamada, Kazutoshi Fujita, Norio Nonomura, Eiji Miyoshi, Miyako Nakano

GLYCOCONJUGATE JOURNAL　Vol. 33　No. 3　p. 471-482　2016/06　Research paper (scientific journal)

Impact of plasma transaminase levels on the peripheral blood glutamate levels and memory functions in healthy subjects

Yoshihiro Kamada, Ryota Hashimoto, Hidenaga Yamamori, Yuka Yasuda, Tetsuo Takehara, Yuko Fujita, Kenji Hashimoto, Eiji Miyoshi

BBA Clinical　Vol. 5　p. 101-107　2016/06/01　Research paper (scientific journal)

Core Fucosylation on T Cells, Required for Activation of T-Cell Receptor Signaling and Induction of Colitis in Mice, Is Increased in Patients With Inflammatory Bowel Disease

Hironobu Fujii, Shinichiro Shinzaki, Hideki Iijima, Kana Wakamatsu, Chizuru Iwamoto, Tomoaki Sobajima, Ryusuke Kuwahara, Satoshi Hiyama, Yoshito Hayashi, Shinji Takamatsu, Naofumi Uozumi, Yoshihiro Kamada, Masahiko Tsujii, Naoyuki Taniguchi, Tetsuo Takehara, Eiji Miyoshi

GASTROENTEROLOGY　Vol. 150　No. 7　p. 1620-1632　2016/06　Research paper (scientific journal)

Site-specific and linkage analyses of fucosylated N-glycans on haptoglobin in sera of patients with various types of cancer: possible implication for the differential diagnosis of cancer

Shiro Takahashi, Taiki Sugiyama, Mayuka Shimomura, Yoshihiro Kamada, Kazutoshi Fujita, Norio Nonomura, Eiji Miyoshi, Miyako Nakano

GLYCOCONJUGATE JOURNAL　Vol. 33　No. 3　p. 471-482　2016/06　Research paper (scientific journal)

Hepatocellular carcinoma in Japanese patients with nonalcoholic fatty liver disease and alcoholic liver disease: multicenter survey

Katsutoshi Tokushige, Hideyuki Hyogo, Tomoaki Nakajima, Masafumi Ono, Takumi Kawaguchi, Koichi Honda, Yuichiro Eguchi, Yuichi Nozaki, Miwa Kawanaka, Saiyu Tanaka, Kento Imajo, Yoshio Sumida, Yoshihiro Kamada, Hideki Fujii, Yasuaki Suzuki, Tomomi Kogiso, Yoshiyasu Karino, Kensuke Munekage, Ryoko Kuromatsu, Satoshi Oeda, Mikio Yanase, Kohjiro Mori, Yuji Ogawa, Yuya Seko, Tetsuo Takehara, Yoshito Itoh, Atsushi Nakajima, Kazuyuki Kanemasa, Ken Nishino, Naohiko Masaki, Hirokazu Takahashi, Masataka Seike, Takuji Torimura, Toshiji Saibara, Joji Toyota, Kazuaki Chayama, Etsuko Hashimoto

JOURNAL OF GASTROENTEROLOGY　Vol. 51　No. 6　p. 586-596　2016/06　Research paper (scientific journal)

Serum Mac-2 binding protein is a novel biomarker for chronic pancreatitis.

Tomohiro Maekawa, Yoshihiro Kamada, Yusuke Ebisutani, Makiko Ueda, Tomoki Hata, Koichi Kawamoto, Shinji Takamatsu, Kayo Mizutani, Mayuka Shimomura, Tomoaki Sobajima, Hironobu Fujii, Kotarosumitomo Nakayama, Kimihiro Nishino, Makoto Yamada, Takashi Kumada, Toshifumi Ito, Hidetoshi Eguchi, Hiroaki Nagano, Eiji Miyoshi

World journal of gastroenterology　Vol. 22　No. 17　p. 4403-10　2016/05/07　Research paper (scientific journal)

N-Acetylglucosaminyltransferase V exacerbates murine colitis with macrophage dysfunction and enhances colitic tumorigenesis

Shinichiro Shinzaki, Mayuko Ishii, Hironobu Fujii, Hideki Iijima, Kana Wakamatsu, Shoichiro Kawai, Eri Shiraishi, Satoshi Hiyama, Takahiro Inoue, Yoshito Hayashi, Ryusuke Kuwahara, Shinji Takamatsu, Yoshihiro Kamada, Eiichi Morii, Masahiko Tsujii, Tetsuo Takehara, Eiji Miyoshi

JOURNAL OF GASTROENTEROLOGY　Vol. 51　No. 4　p. 357-369　2016/04　Research paper (scientific journal)

Role of aberrant IgG glycosylation in the pathogenesis of inflammatory bowel disease

Eiji Miyoshi, Shinichiro Shinzaki, Hironobu Fujii, Hideki Iijima, Yoshihiro Kamada, Tetsuo Takehara

PROTEOMICS CLINICAL APPLICATIONS　Vol. 10　No. 4　p. 384-390　2016/04

Gab1 Adaptor Protein Acts As a Gatekeeper to Balance Hepatocyte Death and Proliferation During Acetaminophen-Induced Liver Injury in Mice

Kunimaro Furuta, Yuichi Yoshida, Satoshi Ogura, Tomohide Kurahashi, Takashi Kizu, Shinichiro Maeda, Mayumi Egawa, Norihiro Chatani, Keigo Nishida, Yoshikazu Nakaoka, Shinichi Kiso, Yoshihiro Kamada, Tetsuo Takehara

HEPATOLOGY　Vol. 63　No. 4　p. 1340-1355　2016/04　Research paper (scientific journal)

Gab1 Adaptor Protein Acts As a Gatekeeper to Balance Hepatocyte Death and Proliferation During Acetaminophen-Induced Liver Injury in Mice

Kunimaro Furuta, Yuichi Yoshida, Satoshi Ogura, Tomohide Kurahashi, Takashi Kizu, Shinichiro Maeda, Mayumi Egawa, Norihiro Chatani, Keigo Nishida, Yoshikazu Nakaoka, Shinichi Kiso, Yoshihiro Kamada, Tetsuo Takehara

HEPATOLOGY　Vol. 63　No. 4　p. 1340-1355　2016/04　Research paper (scientific journal)

Role of aberrant IgG glycosylation in the pathogenesis of inflammatory bowel disease

Eiji Miyoshi, Shinichiro Shinzaki, Hironobu Fujii, Hideki Iijima, Yoshihiro Kamada, Tetsuo Takehara

PROTEOMICS CLINICAL APPLICATIONS　Vol. 10　No. 4　p. 384-390　2016/04　Research paper (scientific journal)

N-Acetylglucosaminyltransferase V exacerbates murine colitis with macrophage dysfunction and enhances colitic tumorigenesis

Shinichiro Shinzaki, Mayuko Ishii, Hironobu Fujii, Hideki Iijima, Kana Wakamatsu, Shoichiro Kawai, Eri Shiraishi, Satoshi Hiyama, Takahiro Inoue, Yoshito Hayashi, Ryusuke Kuwahara, Shinji Takamatsu, Yoshihiro Kamada, Eiichi Morii, Masahiko Tsujii, Tetsuo Takehara, Eiji Miyoshi

JOURNAL OF GASTROENTEROLOGY　Vol. 51　No. 4　p. 357-369　2016/04　Research paper (scientific journal)

Ectopic expression of N-acetylglucosaminyltransferase V accelerates hepatic triglyceride synthesis

Yoshihiro Kamada, Yusuke Ebisutani, Sachiho Kida, Kayo Mizutani, Maaya Akita, Akiko Yamamoto, Hironobu Fujii, Tomoaki Sobajima, Naoko Terao, Shinji Takamatsu, Yuichi Yoshida, Tetsuo Takehara, Eiji Miyoshi

HEPATOLOGY RESEARCH　Vol. 46　No. 3　p. E118-E129　2016/03　Research paper (scientific journal)

Specific increase in serum core-fucosylated haptoglobin in patients with chronic pancreatitis

Makiko Ueda, Yoshihiro Kamada, Shinji Takamatsu, Mayuka Shimomura, Tomohiro Maekawa, Tomoaki Sobajima, Hironobu Fujii, Kotarosumitomo Nakayama, Kimihiro Nishino, Makoto Yamada, Yuka Kobayashi, Takashi Kumada, Toshifumi Ito, Hidetoshi Eguchi, Hiroaki Nagano, Eiji Miyoshi

PANCREATOLOGY　Vol. 16　No. 2　p. 238-243　2016/03　Research paper (scientific journal)

Increase in 6-minute walk distance during hospitalization predicts the readmission due to decompensated heart failure in patients with chronic heart failure

Yoshihiro Kamada

European Heart Journal　2016　Research paper (scientific journal)

Randomized trial of aromatherapy vs. conventional care for breast cancer patients during perioperative periods

Yoshihiro Kamada

Cancer Research　2016　Research paper (scientific journal)

Roles of fucosyltransferases in cancer phenotypes

Eiji Miyoshi, Naofumi Uozumi, Tomoaki Sobajima, Shinji Takamatsu, Yoshihiro Kamada

Glycosignals in Cancer: Mechanisms of Malignant Phenotypes　p. 3-16　2016/01/01　Part of collection (book)

Elevation of CA19-9-Related Novel Marker, Core 1 Sialyl Lewis A, in Sera of Adenocarcinoma Patients Verified by a SRM-Based Method

Miki Tanaka-Okamoto, Masahiko Yabu, Mikio Mukai, Hidenori Takahashi, Yoshiyuki Fujiwara, Masayuki Ohue, Yoshihiro Kamada, Eiji Miyoshi, Yasuhide Miyamoto

JOURNAL OF PROTEOME RESEARCH　Vol. 15　No. 1　p. 152-165　2016/01　Research paper (scientific journal)

Core-fucosylation plays a pivotal role in hepatitis B pseudo virus infection: A possible implication for HBV glycotherapy

Shinji Takamatsu, Mayuka Shimomura, Yoshihiro Kamada, Haruka Maeda, Tomoaki Sobajima, Hayato Hikita, Masumi Iijima, Yuta Okamoto, Ryo Misaki, Kazuhito Fujiyama, Shushi Nagamori, Yoshikatsu Kanai, Tetsuo Takehara, Keiji Ueda, Shun'ichi Kuroda, Eiji Miyoshi

Glycobiology　Vol. 26　No. 11　p. 1180-1189　2016　Research paper (scientific journal)

Specific increase in serum core-fucosylated haptoglobin in patients with chronic pancreatitis.

Ueda M, Kamada Y, lly contributed, Takamatsu S, Shimomura M, Maekawa T, Sobajima T, Fujii H, Nakayama K, Nishino K, Yamada M, Kobayashi Y, Kumada T, Ito T, Eguchi H, Nagano H, Miyoshi E

Pancreatology　Vol. 16　No. 2　p. 238-43　2016/01　Research paper (scientific journal)

Elevation of CA19-9-Related Novel Marker, Core 1 Sialyl Lewis A, in Sera of Adenocarcinoma Patients Verified by a SRM-Based Method

Miki Tanaka-Okamoto, Masahiko Yabu, Mikio Mukai, Hidenori Takahashi, Yoshiyuki Fujiwara, Masayuki Ohue, Yoshihiro Kamada, Eiji Miyoshi, Yasuhide Miyamoto

JOURNAL OF PROTEOME RESEARCH　Vol. 15　No. 1　p. 152-165　2016/01　Research paper (scientific journal)

A novel noninvasive diagnostic method for nonalcoholic steatohepatitis using two glycobiomarkers

Yoshihiro Kamada, Masafumi Ono, Hideyuki Hyogo, Hideki Fujii, Yoshio Sumida, Kojiroh Mori, Saiyu Tanaka, Makoto Yamada, Maaya Akita, Kayo Mizutani, Hironobu Fujii, Akiko Yamamoto, Shinji Takamatsu, Yuichi Yoshida, Yoshito Itoh, Norifumi Kawada, Kazuaki Chayama, Toshiji Saibara, Tetsuo Takehara, Eiji Miyoshi

HEPATOLOGY　Vol. 62　No. 5　p. 1433-1443　2015/11　Research paper (scientific journal)

Secreted frizzled-related protein 5 (Sfrp5) decreases hepatic stellate cell activation and liver fibrosis

Norihiro Chatani, Yoshihiro Kamada, Takashi Kizu, Satoshi Ogura, Kunimaro Furuta, Mayumi Egawa, Mina Hamano, Hisao Ezaki, Shinichi Kiso, Akihiko Shimono, Noriyuki Ouchi, Yuichi Yoshida, Tetsuo Takehara

LIVER INTERNATIONAL　Vol. 35　No. 8　p. 2017-2026　2015/08　Research paper (scientific journal)

Value of fetuin-A as a predictor of liver fibrosis in patients with nonalcoholic fatty liver disease. Author's reply

Yoshihiro Kamada, Eiji Miyoshi

LIVER INTERNATIONAL　Vol. 35　No. 8　p. 2062-2062　2015/08

Value of fetuin-A as a predictor of liver fibrosis in patients with nonalcoholic fatty liver disease. Author's reply

Yoshihiro Kamada, Eiji Miyoshi

LIVER INTERNATIONAL　Vol. 35　No. 8　p. 2062-2062　2015/08　Research paper (scientific journal)

Secreted frizzled-related protein 5 (Sfrp5) decreases hepatic stellate cell activation and liver fibrosis

Norihiro Chatani, Yoshihiro Kamada, Takashi Kizu, Satoshi Ogura, Kunimaro Furuta, Mayumi Egawa, Mina Hamano, Hisao Ezaki, Shinichi Kiso, Akihiko Shimono, Noriyuki Ouchi, Yuichi Yoshida, Tetsuo Takehara

LIVER INTERNATIONAL　Vol. 35　No. 8　p. 2017-2026　2015/08　Research paper (scientific journal)

Establishment of a novel lectin-antibody ELISA system to determine core-fucosylated haptoglobin

Mayuka Shimomura, Kotarosumitomo Nakayama, Kanako Azuma, Naoko Terao, Kimihiro Nishino, Shinji Takamatsu, Miyako Nakano, Shiro Takahashi, Yuka Kobayashi, Kohei Murata, Yoshihiro Kamada, Eiji Miyoshi

CLINICA CHIMICA ACTA　Vol. 446　p. 30-36　2015/06　Research paper (scientific journal)

Ectopic expression of N-acetylglucosaminyltransferase V (GnT-V) accelerates hepatic triglyceride synthesis

Yoshihiro Kamada

Hepatology　2015/06　Research paper (scientific journal)

Establishment of a novel lectin-antibody ELISA system to determine core-fucosylated haptoglobin

Mayuka Shimomura, Kotarosumitomo Nakayama, Kanako Azuma, Naoko Terao, Kimihiro Nishino, Shinji Takamatsu, Miyako Nakano, Shiro Takahashi, Yuka Kobayashi, Kohei Murata, Yoshihiro Kamada, Eiji Miyoshi

CLINICA CHIMICA ACTA　Vol. 446　p. 30-36　2015/06　Research paper (scientific journal)

N-Acetylglucosaminyltransferase V exacerbates concanavalin A-induced hepatitis in mice

Yoshihiro Kamada, Motoya Sato, Sachiho Kida, Maaya Akita, Kayo Mizutani, Hironobu Fujii, Tomoaki Sobajima, Yuichi Yoshida, Shinichiro Shinzaki, Shinji Takamatsu, Tetsuo Takehara, Eiji Miyoshi

MOLECULAR MEDICINE REPORTS　Vol. 11　No. 5　p. 3573-3584　2015/05　Research paper (scientific journal)

N-Acetylglucosaminyltransferase V exacerbates concanavalin A-induced hepatitis in mice

Yoshihiro Kamada, Motoya Sato, Sachiho Kida, Maaya Akita, Kayo Mizutani, Hironobu Fujii, Tomoaki Sobajima, Yuichi Yoshida, Shinichiro Shinzaki, Shinji Takamatsu, Tetsuo Takehara, Eiji Miyoshi

MOLECULAR MEDICINE REPORTS　Vol. 11　No. 5　p. 3573-3584　2015/05　Research paper (scientific journal)

Fucosylation is a common glycosylation type in pancreatic cancer stem cell-like phenotypes

Naoko Terao, Shinji Takamatsu, Tomomi Minehira, Tomoaki Sobajima, Kotarosumitomo Nakayama, Yoshihiro Kamada, Eiji Miyoshi

WORLD JOURNAL OF GASTROENTEROLOGY　Vol. 21　No. 13　p. 3876-3887　2015/04　Research paper (scientific journal)

Loss of Gab1 adaptor protein in hepatocytes aggravates experimental liver fibrosis in mice

Takashi Kizu, Yuichi Yoshida, Kunimaro Furuta, Satoshi Ogura, Mayumi Egawa, Norihiro Chatani, Mina Hamano, Takayo Takemura, Hisao Ezaki, Yoshihiro Kamada, Keigo Nishida, Yoshikazu Nakaoka, Shinichi Kiso, Tetsuo Takehara

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY　Vol. 308　No. 7　p. G613-G624　2015/04　Research paper (scientific journal)

Fucosylation is a common glycosylation type in pancreatic cancer stem cell-like phenotypes

Naoko Terao, Shinji Takamatsu, Tomomi Minehira, Tomoaki Sobajima, Kotarosumitomo Nakayama, Yoshihiro Kamada, Eiji Miyoshi

WORLD JOURNAL OF GASTROENTEROLOGY　Vol. 21　No. 13　p. 3876-3887　2015/04　Research paper (scientific journal)

Fetuin-A negatively correlates with liver and vascular fibrosis in nonalcoholic fatty liver disease subjects

Motoya Sato, Yoshihiro Kamada, Yuri Takeda, Sachiho Kida, Yuka Ohara, Hironobu Fujii, Maaya Akita, Kayo Mizutani, Yuichi Yoshida, Makoto Yamada, Hidetaka Hougaku, Tetsuo Takehara, Eiji Miyoshi

LIVER INTERNATIONAL　Vol. 35　No. 3　p. 925-935　2015/03　Research paper (scientific journal)

Fetuin-A negatively correlates with liver and vascular fibrosis in nonalcoholic fatty liver disease subjects

Motoya Sato, Yoshihiro Kamada, Yuri Takeda, Sachiho Kida, Yuka Ohara, Hironobu Fujii, Maaya Akita, Kayo Mizutani, Yuichi Yoshida, Makoto Yamada, Hidetaka Hougaku, Tetsuo Takehara, Eiji Miyoshi

LIVER INTERNATIONAL　Vol. 35　No. 3　p. 925-935　2015/03　Research paper (scientific journal)

Loss of alpha 1,6-fucosyltransferase suppressed liver regeneration: implication of core fucose in the regulation of growth factor receptor-mediated cellular signaling

Yuqin Wang, Tomohiko Fukuda, Tomoya Isaji, Jishun Lu, Wei Gu, Ho-hsun Lee, Yasuhito Ohkubo, Yoshihiro Kamada, Naoyuki Taniguchi, Eiji Miyoshi, Jianguo Gu

SCIENTIFIC REPORTS　Vol. 5　2015/02　Research paper (scientific journal)

Hepatosteatosis and Primary Hepatoma

Eiji Miyoshi, Yoshihiro Kamada

Glycoscience: Biology and Medicine　p. 1365-1371　2015/01/01　Part of collection (book)

Serum fucosylated haptoglobin in chronic liver diseases as a potential biomarker of hepatocellular carcinoma development

Hitomi Asazawa, Yoshihiro Kamada, Yuri Takeda, Shinji Takamatsu, Shinichiro Shinzaki, Youkoku Kim, Riichiro Nezu, Noriyoshi Kuzushita, Eiji Mita, Michio Kato, Eiji Miyoshi

CLINICAL CHEMISTRY AND LABORATORY MEDICINE　Vol. 53　No. 1　p. 95-102　2015/01　Research paper (scientific journal)

Serum fucosylated haptoglobin in chronic liver diseases as a potential biomarker of hepatocellular carcinoma development

Hitomi Asazawa, Yoshihiro Kamada, Yuri Takeda, Shinji Takamatsu, Shinichiro Shinzaki, Youkoku Kim, Riichiro Nezu, Noriyoshi Kuzushita, Eiji Mita, Michio Kato, Eiji Miyoshi

CLINICAL CHEMISTRY AND LABORATORY MEDICINE　Vol. 53　No. 1　p. 95-102　2015/01　Research paper (scientific journal)

Identification of Sialylated Glycoproteins in Doxorubicin-Treated Hepatoma Cells with Glycoproteomic Analyses

Kanako Azuma, Satoshi Serada, Shinji Takamatsu, Naoko Terao, Shunsaku Takeishi, Yoshihiro Kamada, Tetsuji Naka, Eiji Miyoshi

JOURNAL OF PROTEOME RESEARCH　Vol. 13　No. 11　p. 4869-4877　2014/11　Research paper (scientific journal)

Identification of Sialylated Glycoproteins in Doxorubicin-Treated Hepatoma Cells with Glycoproteomic Analyses

Kanako Azuma, Satoshi Serada, Shinji Takamatsu, Naoko Terao, Shunsaku Takeishi, Yoshihiro Kamada, Tetsuji Naka, Eiji Miyoshi

JOURNAL OF PROTEOME RESEARCH　Vol. 13　No. 11　p. 4869-4877　2014/11　Research paper (scientific journal)

Pancreatic Fatty Degeneration and Fibrosis as Predisposing Factors for the Development of Pancreatic Ductal Adenocarcinoma

Yasuhiko Tomita, Kanako Azuma, Yuji Nonaka, Yoshihiro Kamada, Miki Tomoeda, Mioka Kishida, Masahiro Tanemura, Eiji Miyoshi

PANCREAS　Vol. 43　No. 7　p. 1032-1041　2014/10　Research paper (scientific journal)

Twin studies on the effect of genetic factors on serum agalactosyl immunoglobulin G levels.

Azuma K, Shinzaki S, Asazawa H, Kuroki E, Kawamoto S, Kamada Y, Hayakawa K, Miyoshi E

Biomedical reports　Vol. 2　No. 2　p. 213-216　2014/03　Research paper (scientific journal)

Lipid overloading during liver regeneration causes delayed hepatocyte DNA replication by increasing ER stress in mice with simple hepatic steatosis

Mina Hamano, Hisao Ezaki, Shinichi Kiso, Kunimaro Furuta, Mayumi Egawa, Takashi Kizu, Norihiro Chatani, Yoshihiro Kamada, Yuichi Yoshida, Tetsuo Takehara

JOURNAL OF GASTROENTEROLOGY　Vol. 49　No. 2　p. 305-316　2014/02　Research paper (scientific journal)

Pancreatic fatty degeneration and fibrosis as predisposing factors for the development of pancreatic ductal adenocarcinoma

Yasuhiko Tomita, Kanako Azuma, Yuji Nonaka, Yoshihiro Kamada, Miki Tomoeda, Mioka Kishida, Masahiro Tanemura, Eiji Miyoshi

Pancreas　Vol. 43　No. 7　p. 1032-1041　2014　Research paper (scientific journal)

An update on the diagnosis and examination of NAFLD

Yoshihiro Kamada, Eiji Miyoshi, Tetsuo Takehara

Journal of Japanese Society of Gastroenterology　Vol. 111　No. 1　p. 25-34　2014/01　Research paper (scientific journal)

Novel effect of ezetimibe to inhibit the development of non-alcoholic fatty liver disease in Fatty Liver Shionogi mouse

Xiang Wang, Ken Sugimoto, Tomomi Fujisawa, Nobuyasu Shindo, Satomi Minato, Yoshihiro Kamada, Mina Hamano, Mitsuru Ohishi, Hiroshi Ikegami, Hiromi Rakugi

HEPATOLOGY RESEARCH　Vol. 44　No. 1　p. 102-113　2014/01　Research paper (scientific journal)

Serum Mac-2 binding protein levels as a novel diagnostic biomarker for prediction of disease severity and nonalcoholic steatohepatitis

Yoshihiro Kamada, Hideki Fujii, Hironobu Fujii, Yoshiyuki Sawai, Yoshinori Doi, Naofumi Uozumi, Kayo Mizutani, Maaya Akita, Motoya Sato, Sachiho Kida, Noriaki Kinoshita, Nobuhiro Maruyama, Takayuki Yakushijin, Masanori Miyazaki, Hisao Ezaki, Naoki Hiramatsu, Yuichi Yoshida, Shinichi Kiso, Yasuharu Imai, Norifumi Kawada, Tetsuo Takehara, Eiji Miyoshi

PROTEOMICS CLINICAL APPLICATIONS　Vol. 7　No. 9-10　p. 648-656　2013/10　Research paper (scientific journal)

Conditional loss of heparin-binding EGF-like growth factor results in enhanced liver fibrosis after bile duct ligation in mice

Takayo Takemura, Yuichi Yoshida, Shinichi Kiso, Takashi Kizu, Kunimaro Furuta, Hisao Ezaki, Mina Hamano, Mayumi Egawa, Norihiro Chatani, Yoshihiro Kamada, Yasuharu Imai, Shigeki Higashiyama, Ryo Iwamoto, Eisuke Mekada, Tetsuo Takehara

Biochemical and Biophysical Research Communications　Vol. 437　No. 2　p. 185-191　2013/07/26　Research paper (scientific journal)

Mutation of GDP-Mannose-4,6-Dehydratase in Colorectal Cancer Metastasis

Kotarosumitomo Nakayama, Kenta Moriwaki, Taku Imai, Shinichiro Shinzaki, Yoshihiro Kamada, Kohei Murata, Eiji Miyoshi

PLOS ONE　Vol. 8　No. 7　2013/07　Research paper (scientific journal)

糖鎖がんマーカー

三善英知, 鎌田佳宏, 魚住尚史

実験医学　2013/06

Conditional knockout of heparin-binding epidermal growth factor-like growth factor in the liver accelerates carbon tetrachloride-induced liver injury in mice

Takayo Takemura, Yuichi Yoshida, Shinichi Kiso, Yukiko Saji, Hisao Ezaki, Mina Hamano, Takashi Kizu, Mayumi Egawa, Norihiro Chatani, Kunimaro Furuta, Yoshihiro Kamada, Ryo Iwamoto, Eisuke Mekada, Shigeki Higashiyama, Norio Hayashi, Tetsuo Takehara

HEPATOLOGY RESEARCH　Vol. 43　No. 4　p. 384-393　2013/04　Research paper (scientific journal)

Pitavastatin ameliorated the progression of steatohepatitis in ovariectomized mice fed a high fat and high cholesterol diet

Yoshihiro Kamada, Shinichi Kiso, Yuichi Yoshida, Norihiro Chatani, Takashi Kizu, Mina Hamano, Mayumi Egawa, Takayo Takemura, Hisao Ezaki, Kunimaro Furuta, Norio Hayashi, Tetsuo Takehara

HEPATOLOGY RESEARCH　Vol. 43　No. 4　p. 401-412　2013/04　Research paper (scientific journal)

Adiponectin negatively correlates with alcoholic and non-alcoholic liver dysfunction: Health check-up study of Japanese men

Mina Hamano, Yoshihiro Kamada, Shinichi Kiso, Kunimaro Furuta, Takashi Kizu, Norihiro Chatani, Mayumi Egawa, Takayo Takemura, Hisao Ezaki, Yuichi Yoshida, Kenji Watabe, Toshimitsu Hamasaki, Miyuki Umeda, Aiko Furubayashi, Kazuo Kinoshita, Osamu Kishida, Takashi Fujimoto, Akira Yamada, Yoshifumi Tsukamoto, Shusaku Tsutsui, Tetsuo Takehara, Norio Hayashi, Yuji Matsuzawa

HEPATOLOGY RESEARCH　Vol. 43　No. 3　p. 238-248　2013/03　Research paper (scientific journal)

Reevaluation of a lectin antibody ELISA kit for measuring fucosylated haptoglobin in various conditions

Yoshihiro Kamada, Noriaki Kinoshita, Yoko Tsuchiya, Kyoko Kobayashi, Hironobu Fujii, Naoko Terao, Kyoko Kamihagi, Nobuto Koyama, Shin Yamada, Yataro Daigo, Yusuke Nakamura, Naoyuki Taniguchi, Eiji Miyoshi

CLINICA CHIMICA ACTA　Vol. 417　p. 48-53　2013/02　Research paper (scientific journal)

Lectin-based immunoassay for aberrant IgG glycosylation as the biomarker for Crohn's disease

Shinichiro Shinzaki, Eri Kuroki, Hideki Iijima, Norika Tatsunaka, Mayuko Ishii, Hironobu Fujii, Yoshihiro Kamada, Taku Kobayashi, Narihiro Shibukawa, Takahiro Inoue, Masahiko Tsujii, Shunsaku Takeishi, Tsunekazu Mizushima, Atsushi Ogata, Tetsuji Naka, Scott E. Plevy, Tetsuo Takehara, Eiji Miyoshi

Inflammatory Bowel Diseases　Vol. 19　No. 2　p. 321-331　2013/02　Research paper (scientific journal)

Lack of secreted frizzled-related protein 5 (Sfrp5), an adipocytokine, enhanced carbon-tetrachloride-induced liver fibrosis in mice

Yoshihiro Kamada

Hepatology　2013　Research paper (scientific journal)

Utility of acoustic radiation force impulse (ARFI) to assess liver fibrosis in chronic hepatitis C patients receiving triple therapy with NS3/4 protease inhibitors

Yoshihiro Kamada

Hepatology　2013　Research paper (scientific journal)

Serum Mac-2 binding protein levels as a novel diagnostic biomarker for prediction of disease severity and nonalcoholic steatohepatitis

Yoshihiro Kamada

Hepatology　2013　Research paper (scientific journal)

REDUCED TET2 FUNCTION CONTRIBUTES TO DEVELOPMENT OF PERIPHERAL T-CELL LYMPHOMA THROUGH IMPAIRMENT OF EPIGENETIC REGULATION

Yoshihiro Kamada

Haematologica　2013　Research paper (scientific journal)

Immediate effect of neuromuscular electrical stimulation on vascular endothelial function in patients with acute myocardial infarction

Yoshihiro Kamada

European Heart Journal　2013　Research paper (scientific journal)

A non-invasive modality the US virtual touch tissue quantification (VTTQ) for evaluation of breast cancer

Kentaro Tamaki, Nobumitsu Tamaki, Yoshihiko Kamada, Kano Uehara, Minoru Miyashita, Takanori Ishida, Hironobu Sasano

Cancer Research　Vol. 43　No. 9　p. 889-895　2013　Research paper (scientific journal)

Analysis of polarized secretion of fucosylated AFP (AFP-L3) in HepG2 cells

Nakagawa Tsutomu, Moriwaki Kenta, Terao Naoko, Nakagawa Takatoshi, Miyamoto Yasuhide, Kamada Yoshihiro, Miyoshi Eiji

Japan Journal of Molecular Tumor Marker Research　Vol. 28　p. 25-26　2013

Serum Fucosylated Haptoglobin as a Novel Diagnostic Biomarker for Predicting Hepatocyte Ballooning and Nonalcoholic Steatohepatitis.

Yoshihiro Kamada, Maaya Akita, Yuri Takeda, Shin Yamada, Hideki Fujii, Yoshiyuki Sawai, Yoshinori Doi, Hitomi Asazawa, Kotarosumitomo Nakayama, Kayo Mizutani, Hironobu Fujii, Takayuki Yakushijin, Masanori Miyazaki, Hisao Ezaki, Naoki Hiramatsu, Yuichi Yoshida, Shinichi Kiso, Yasuharu Imai, Norifumi Kawada, Tetsuo Takehara, Eiji Miyoshi

PloS one　Vol. 8　No. 6　2013　Research paper (scientific journal)

ポリラクトサミンを介したB細胞とマクロファージによる腸炎抑制機構

藤井 宏修, 新崎 信一郎, 飯島 英樹, 石井 真悠子, 鎌田 佳宏, 高松 真二, 傍嶋 智明, 竹原 徹郎, 三善 英知

日本生化学会大会プログラム・講演要旨集　Vol. 85回　p. 3T16-09　2012/12

N-アセチルグルコサミン転移酵素V(GnT-V)は、マクロファージの機能不全を介して腸管炎症を増悪させる

石井 真悠子, 新崎 信一郎, 藤井 宏修, 竜中 法佳, 鎌田 佳宏, 飯島 英樹, 竹原 徹郎, 三善 英知

日本生化学会大会プログラム・講演要旨集　Vol. 85回　p. 3P-039　2012/12

Physiological roles of N-acetylglucosaminyltransferase V (GnT-V) in mice

Eiji Miyoshi, Mika Terao, Yoshihiro Kamada

BMB REPORTS　Vol. 45　No. 10　p. 554-559　2012/10　Research paper (scientific journal)

ヒト大腸癌組織におけるフコシル化欠損とGMDSの変異(Loss of fucosylation through GMDS mutation in human colon cancer tissue)

中山 小太郎純友, 森脇 健太, 今井 拓, 下村 真由香, 新崎 信一郎, 鎌田 佳宏, 村田 幸平, 三善 英知

日本癌学会総会記事　Vol. 71回　p. 467-467　2012/08

N-Acetylglucosaminyltransferase V regulates TGF-beta response in hepatic stellate cells and the progression of steatohepatitis

Yoshihiro Kamada, Kanako Mori, Hitoshi Matsumoto, Shinichi Kiso, Yuichi Yoshida, Shinichiro Shinzaki, Naoki Hiramatsu, Mayuko Ishii, Kenta Moriwaki, Norifumi Kawada, Tetsuo Takehara, Eiji Miyoshi

GLYCOBIOLOGY　Vol. 22　No. 6　p. 778-787　2012/06　Research paper (scientific journal)

Analysis of Polarized Secretion of Fucosylated Alpha-Fetoprotein in HepG2 Cells

Tsutomu Nakagawa, Kenta Moriwaki, Naoko Terao, Takatoshi Nakagawa, Yasuhide Miyamoto, Yoshihiro Kamada, Eiji Miyoshi

JOURNAL OF PROTEOME RESEARCH　Vol. 11　No. 5　p. 2798-2806　2012/05　Research paper (scientific journal)

Protective role of adiponectin against ethanol-induced gastric injury in mice

Shunsuke Yamamoto, Kenji Watabe, Hiroshi Araki, Yoshihiro Kamada, Motohiko Kato, Takashi Kizu, Shinichi Kiso, Shusaku Tsutsui, Masahiko Tsujii, Shinji Kihara, Tohru Funahashi, Iichiro Shimomura, Norio Hayashi, Tetsuo Takehara

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY　Vol. 302　No. 8　p. G773-G780　2012/04　Research paper (scientific journal)

A newly angiogenic biomarker Vasohibin-1 expression in ductal carcinoma in situ of the breast

Yoshihiro Kamada

Cancer Research　2012　Research paper (scientific journal)

Isolation and characterization of cancer stem cells with methods of glycotechnology

Terao Naoko, Okudo Kumiko, Moriwaki Kenta, Sasaki Yumeka, Yamatani Erika, Kamada Yoshihiro, Haraguchi Naotsugu, Takeishi Shunsaku, Sawaki Hiromichi, Narimatsu Hisashi, Mori Masaki, Miyoshi Eiji

Japan Journal of Molecular Tumor Marker Research　Vol. 27　p. 15-16　2012

Fucosylation is a promising target for cancer diagnosis and therapy

Eiji Miyoshi, Kenta Moriwaki, Naoko Terao, Cheng-Cheng Tan, Mika Terao, Tsutomu Nakagawa, Hitoshi Matsumoto, Shinichiro Shinzaki, Yoshihiro Kamada

Biomolecules　Vol. 2　No. 1　p. 34-45　2012　Research paper (scientific journal)

Association of low serum adiponectin levels with erosive esophagitis in men: an analysis of 2405 subjects undergoing physical check-ups

Motohiko Kato, Kenji Watabe, Toshimitsu Hamasaki, Miyuki Umeda, Aiko Furubayashi, Kazuo Kinoshita, Osamu Kishida, Takashi Fujimoto, Akira Yamada, Yoshifumi Tsukamoto, Shunsuke Yamamoto, Yoshihiro Kamada, Yuichi Yoshida, Shinichi Kiso, Shusaku Tsutsui, Shinji Kihara, Norio Hayashi, Yuji Matsuzawa

JOURNAL OF GASTROENTEROLOGY　Vol. 46　No. 12　p. 1361-1367　2011/12　Research paper (scientific journal)

Association of low serum adiponectin levels with erosive esophagitis in men: an analysis of 2405 subjects undergoing physical check-ups

Motohiko Kato, Kenji Watabe, Toshimitsu Hamasaki, Miyuki Umeda, Aiko Furubayashi, Kazuo Kinoshita, Osamu Kishida, Takashi Fujimoto, Akira Yamada, Yoshifumi Tsukamoto, Shunsuke Yamamoto, Yoshihiro Kamada, Yuichi Yoshida, Shinichi Kiso, Shusaku Tsutsui, Shinji Kihara, Norio Hayashi, Yuji Matsuzawa

JOURNAL OF GASTROENTEROLOGY　Vol. 46　No. 12　p. 1361-1367　2011/12　Research paper (scientific journal)

Estrogen deficiency worsens steatohepatitis in mice fed high-fat and high-cholesterol diet

Yoshihiro Kamada, Shinichi Kiso, Yuichi Yoshida, Norihiro Chatani, Takashi Kizu, Mina Hamano, Mayumi Tsubakio, Takayo Takemura, Hisao Ezaki, Norio Hayashi, Tetsuo Takehara

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY　Vol. 301　No. 6　p. G1031-G1043　2011/12　Research paper (scientific journal)

PITAVASTATIN ADMINISTRATION AMELIORATED THE PROGRESSION OF STEATOHEPATITIS IN OVARIECTOMIZED MICE FED WITH HIGH FAT AND HIGH CHOLESTEROL DIET

Yoshihiro Kamada

Hepatology　2011/11　Research paper (scientific journal)

様々なレクチンによって分離した癌幹細胞の特徴(Characterization of cancer stem cells isolated with several kinds oflectin-based technology)

佐々木 夢香, 奥戸 久美子, 寺尾 尚子, 森脇 健太, 新崎 信一郎, 鎌田 佳宏, 三善 英知

日本癌学会総会記事　Vol. 70回　p. 65-65　2011/09

Sp1によるGMDSの遺伝子発現とフコシル化の制御(Sp1 regulates gene expression of GMDS and fucosylation)

今井 拓, 森脇 健太, 中山 小太郎純友, 東 加奈子, 新崎 信一郎, 鎌田 佳宏, 三善 英知

日本癌学会総会記事　Vol. 70回　p. 226-226　2011/09

ヒト大腸癌由来転移巣におけるGMDS遺伝子変異の発見(The detection of GMDS gene mutations in metastatic lesion of human colon cancer)

中山 小太郎純友, 森脇 健太, 今井 拓, 新崎 信一郎, 鎌田 佳宏, 村田 幸平, 三善 英知

日本癌学会総会記事　Vol. 70回　p. 327-327　2011/09

Enhanced Epithelial-Mesenchymal Transition-like Phenotype in N-Acetylglucosaminyltransferase V Transgenic Mouse Skin Promotes Wound Healing

Mika Terao, Akiko Ishikawa, Susumu Nakahara, Akihiro Kimura, Arisa Kato, Kenta Moriwaki, Yoshihiro Kamada, Hiroyuki Murota, Naoyuki Taniguchi, Ichiro Katayama, Eiji Miyoshi

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 286　No. 32　p. 28303-28311　2011/08　Research paper (scientific journal)

Lower Serum Level of Adiponectin Is Associated with Increased Risk of Endoscopic Erosive Gastritis

Shunsuke Yamamoto, Kenji Watabe, Shusaku Tsutsui, Shinichi Kiso, Toshimitsu Hamasaki, Motohiko Kato, Yoshihiro Kamada, Yuichi Yoshida, Shinji Kihara, Miyuki Umeda, Aiko Furubayashi, Kazuo Kinoshita, Osamu Kishida, Takashi Fujimoto, Akira Yamada, Yoshifumi Tsukamoto, Norio Hayashi, Yuji Matsuzawa

DIGESTIVE DISEASES AND SCIENCES　Vol. 56　No. 8　p. 2354-2360　2011/08　Research paper (scientific journal)

Lower Serum Level of Adiponectin Is Associated with Increased Risk of Endoscopic Erosive Gastritis

Shunsuke Yamamoto, Kenji Watabe, Shusaku Tsutsui, Shinichi Kiso, Toshimitsu Hamasaki, Motohiko Kato, Yoshihiro Kamada, Yuichi Yoshida, Shinji Kihara, Miyuki Umeda, Aiko Furubayashi, Kazuo Kinoshita, Osamu Kishida, Takashi Fujimoto, Akira Yamada, Yoshifumi Tsukamoto, Norio Hayashi, Yuji Matsuzawa

DIGESTIVE DISEASES AND SCIENCES　Vol. 56　No. 8　p. 2354-2360　2011/08　Research paper (scientific journal)

Enhanced Epithelial-Mesenchymal Transition-like Phenotype in N-Acetylglucosaminyltransferase V Transgenic Mouse Skin Promotes Wound Healing

Mika Terao, Akiko Ishikawa, Susumu Nakahara, Akihiro Kimura, Arisa Kato, Kenta Moriwaki, Yoshihiro Kamada, Hiroyuki Murota, Naoyuki Taniguchi, Ichiro Katayama, Eiji Miyoshi

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 286　No. 32　p. 28303-28311　2011/08　Research paper (scientific journal)

メタボリックシンドローム、低アディポネクチン血症と病態

鎌田佳宏

メタボリックシンドローム―低アディポネクチン血症と動脈硬化学　2011/04

アディポサイトカイン

鎌田佳宏

カレントテラピー　2010/12

ESTROGEN DEFICIENCY ENHANCED THE PROGRESSION OF STEATOHEPATITIS WITH INCREASED MACROPHAGE INFILTRATION IN MICE FED WITH HIGH FAT AND HIGH CHOLESTEROL DIET

Yoshihiro Kamada

Hepatology　2010/11　Research paper (scientific journal)

Adipocytokine regulation in steatohepatitis

Yoshihiro Kamada, Shinichi Kiso, Tetsuo Takehara, Norio Hayashi

2010/11　Research paper (international conference proceedings)

エストロゲン欠乏状態（閉経後）における高コレステロール血症のNASH病態進展への関与

鎌田佳宏, 木曽真一, 林 紀夫

2010/10　Research paper (other academic)

糖転移酵素N-アセチルグルコサミン転移酵素V(GnT-V)は肝線維化及び炎症を抑制する(N-Acetylglucosaminyltransferase V suppresses liver fibrosis and inflammation induced by high fat high cholesterol diet)

森 華奈子, 松本 仁, 鎌田 佳宏, 戸田 美樹, 新崎 信一郎, 河田 則文, 吉田 雄一, 木曽 真一, 林 紀夫, 三善 英知

日本癌学会総会記事　Vol. 69回　p. 81-81　2010/08

ヒト肝細胞癌におけるアダプター蛋白質Gab1の関与(Role of Gab1 scaffolding adaptor protein in human hepatocellular carcinoma)

戸田 美樹, 吉田 雄一, 森 華奈子, 新崎 信一郎, 鎌田 佳宏, 木曽 真一, 三善 英知, 林 紀夫

日本癌学会総会記事　Vol. 69回　p. 168-168　2010/08

Lack of adiponectin promotes formation of cholesterol gallstones in mice

Hideharu Ogiyama, Yoshihiro Kamada, Shinichi Kiso, Hiroshi Araki, Takuya Yamada, Tamao Nishihara, Kenji Watabe, Yoshihiro Tochino, Shinji Kihara, Tohru Funahashi, Keishi Kanno, Iichiro Shimomura, Shusaku Tsutsui, Susumu Tazuma, Norio Hayashi

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 399　No. 3　p. 352-358　2010/08　Research paper (scientific journal)

Lack of adiponectin promotes formation of cholesterol gallstones in mice

Hideharu Ogiyama, Yoshihiro Kamada, Shinichi Kiso, Hiroshi Araki, Takuya Yamada, Tamao Nishihara, Kenji Watabe, Yoshihiro Tochino, Shinji Kihara, Tohru Funahashi, Keishi Kanno, Iichiro Shimomura, Shusaku Tsutsui, Susumu Tazuma, Norio Hayashi

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 399　No. 3　p. 352-358　2010/08　Research paper (scientific journal)

Adiponectin deficiency enhanced the severity of cerulein-induced chronic pancreatitis in mice

Takuya Yamada, Hiroshi Araki, Kenji Watabe, Yoshihiro Kamada, Shinichi Kiso, Hideharu Ogiyama, Tamao Nishihara, Shinji Kihara, Tohru Funahashi, Iichiro Shimomura, Shusaku Tsutsui, Norio Hayashi

JOURNAL OF GASTROENTEROLOGY　Vol. 45　No. 7　p. 742-749　2010/07　Research paper (scientific journal)

Adiponectin deficiency enhanced the severity of cerulein-induced chronic pancreatitis in mice

Takuya Yamada, Hiroshi Araki, Kenji Watabe, Yoshihiro Kamada, Shinichi Kiso, Hideharu Ogiyama, Tamao Nishihara, Shinji Kihara, Tohru Funahashi, Iichiro Shimomura, Shusaku Tsutsui, Norio Hayashi

JOURNAL OF GASTROENTEROLOGY　Vol. 45　No. 7　p. 742-749　2010/07　Research paper (scientific journal)

NASHとアディポネクチン

鎌田佳宏

アディポサイエンス　2010/04

リジン尿性タンパク不耐症（lysinuric protein intolerance: LPI）の1例とその病態解析

鎌田佳宏, 木曽真一, 林 紀夫

第38回日本肝臓学会西部会記念誌「遺伝性肝疾患」　2010/04　Research paper (scientific journal)

リジン尿性タンパク不耐症の一例：アルギニン欠乏による血中NO低下が引き起こす様々な病態について

鎌田佳宏, 木曽真一, 林 紀夫

2009/12　Research paper (other academic)

卵巣摘出マウスを用いた閉経後のNASH進展メカニズムの解析

鎌田佳宏, 木曽真一, 林 紀夫

2009/12　Research paper (other academic)

Visceral obesity and hypoadiponectinemia are significant determinants of hepatic dysfunction: An epidemiologic study of 3827 japanese subjects

Yoshihiro Kamada, Tadashi Nakamura, Tohru Funahashi, Miwa Ryo, Hitoshi Nishizawa, Yukiyoshi Okauchi, Juichi Fukushima, Yuichi Yoshida, Shinichi Kiso, Iichiro Shimomura, Norio Hayashi

Journal of Clinical Gastroenterology　Vol. 43　No. 10　p. 995-1000　2009/11　Research paper (scientific journal)

Visceral Obesity and Hypoadiponectinemia are Significant Determinants of Hepatic Dysfunction An Epidemiologic Study of 3827 Japanese Subjects

Yoshihiro Kamada, Adashi Nakamura, Tohru Funahashi, Miwa Ryo, Hitoshi Nishizawa, Yukiyoshi Okauchi, Juichi Fukushima, Yuichi Yoshida, Shinichi Kiso, Iichiro Shimomura, Norio Hayashi

JOURNAL OF CLINICAL GASTROENTEROLOGY　Vol. 43　No. 10　p. 995-1000　2009/11　Research paper (scientific journal)

内臓脂肪蓄積とアディポサイトカイン分泌異常

鎌田佳宏, 福島寿一, 林 紀夫

治療学　2009/10

Adiponectin prevents progression of steatohepatitis in mice by regulating oxidative stress and Kupffer cell phenotype polarization

Juichi Fukushima, Yoshihiro Kamada, Hitoshi Matsumoto, Yuichi Yoshida, Hisao Ezaki, Takayo Takemura, Yukiko Saji, Takumi Igura, Shusaku Tsutsui, Shinji Kihara, Tohru Funahashi, Iichiro Shimomura, Shinji Tamura, Shinichi Kiso, Norio Hayashi

HEPATOLOGY RESEARCH　Vol. 39　No. 7　p. 724-738　2009/07　Research paper (scientific journal)

Adiponectin prevents progression of steatohepatitis in mice by regulating oxidative stress and Kupffer cell phenotype polarization

Juichi Fukushima, Yoshihiro Kamada, Hitoshi Matsumoto, Yuichi Yoshida, Hisao Ezaki, Takayo Takemura, Yukiko Saji, Takumi Igura, Shusaku Tsutsui, Shinji Kihara, Tohru Funahashi, Iichiro Shimomura, Shinji Tamura, Shinichi Kiso, Norio Hayashi

HEPATOLOGY RESEARCH　Vol. 39　No. 7　p. 724-738　2009/07　Research paper (scientific journal)

一般健常者における肝機能検査値と内臓脂肪面積、血清アディポネクチン値の相関についての疫学的検討

鎌田佳宏, 木曽真一, 中村 正, 船橋 徹, 福島寿一, 吉田雄一, 江崎久男, 竹村貴代, 筒井秀作, 下村伊一郎, 林 紀夫

2009/06　Research paper (other academic)

アディポサイトカインのNASH進展における意義を探る

鎌田佳宏, 松本 仁, 林 紀夫

分子消化器病　2009/04

NASH進展に対するアディポネクチンの意義

鎌田佳宏, 木曽真一, 林 紀夫

第94回日本消化器病学会総会記念誌　2009/04　Research paper (scientific journal)

肝臓における脂肪蓄積とインスリン抵抗性

鎌田佳宏, 下村伊一郎

アディポサイエンス　2009/04

Transplantation of basic fibroblast growth factor-pretreated adipose tissue-derived stromal cells enhances regression of liver fibrosis in mice

Yoshihiro Kamada, Yuichi Yoshida, Yukiko Saji, Juichi Fukushima, Shinji Tamura, Shinichi Kiso, Norio Hayashi

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY　Vol. 296　No. 2　p. G157-G167　2009/02　Research paper (scientific journal)

Transplantation of basic fibroblast growth factor-pretreated adipose tissue-derived stromal cells enhances regression of liver fibrosis in mice

Yoshihiro Kamada, Yuichi Yoshida, Yukiko Saji, Juichi Fukushima, Shinji Tamura, Shinichi Kiso, Norio Hayashi

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY　Vol. 296　No. 2　p. G157-G167　2009/02　Research paper (scientific journal)

Delayed liver regeneration after partial hepatectomy in adiponectin knockout mice

Hisao Ezaki, Yuichi Yoshida, Yukiko Saji, Takayo Takemura, Juichi Fukushima, Hitoshi Matsumoto, Yoshihiro Kamada, Akira Wada, Takumi Igura, Shinji Kihara, Tohru Funahashi, Iichiro Shimomura, Shinji Tamura, Shinichi Kiso, Norio Hayashi

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 378　No. 1　p. 68-72　2009/01　Research paper (scientific journal)

Delayed liver regeneration after partial hepatectomy in adiponectin knockout mice

Hisao Ezaki, Yuichi Yoshida, Yukiko Saji, Takayo Takemura, Juichi Fukushima, Hitoshi Matsumoto, Yoshihiro Kamada, Akira Wada, Takumi Igura, Shinji Kihara, Tohru Funahashi, Iichiro Shimomura, Shinji Tamura, Shinichi Kiso, Norio Hayashi

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 378　No. 1　p. 68-72　2009/01　Research paper (scientific journal)

LACK OF ADIPONECTIN ENHANCED OXIDATIVE STRESS IN MICE NASH MODEL THROUGH DECREASED HEPATIC CATALASE EXPRESSION

Yoshihiro Kamada

Hepatology　2008/11　Research paper (scientific journal)

GAB FAMILY SCAFFOLDING ADAPTOR PROTEINS ARE ESSENTIAL FOR LIVER REGENERATION AFTER PARTIAL HEPATECTOMY

Yoshihiro Kamada

Hepatology　2008/11　Research paper (scientific journal)

TRANSPLANTATION OF BASIC FIBROBLAST GROWTH FACTOR-PRETREATED ADIPOSE TISSUE-DERIVED STROMAL CELLS ENHANCES REGRESSION OF LIVER FIBROSIS AND RESTORES HEPATIC FUNCTIONS IN MICE

Yoshihiro Kamada

Hepatology　2008/11　Research paper (scientific journal)

Molecular chaperon, oxygen-regulated protein150 (ORP150), suppressed palmitate induced hepatocyte apoptosis through reducing ER stress.

Hitoshi Matsumoto, Eiji Miyoshi, Yoshihiro Kamada, Yuichi Yoshida, Kentaro Ozawa, Satoshi Ogawa, Shinichi Kiso, Norio Hayashi

2008/11　Research paper (international conference proceedings)

Adipocytokines and liver disease

Yoshihiro Kamada, Tetsuo Takehara, Norio Hayashi

JOURNAL OF GASTROENTEROLOGY　Vol. 43　No. 11　p. 811-822　2008/11

非アルコール性脂肪性肝炎（NASH）進展におけるアディポネクチンの意義

鎌田佳宏, 下村伊一郎, 林 紀夫

2008/10　Research paper (other academic)

脂肪組織由来間葉系幹細胞 (ADSC)を用いた肝再生療法開発へ向けた検討-bFGF前処置ADSCの有用性について

鎌田佳宏, 木曽真一, 林 紀夫

2008/10　Research paper (other academic)

Adiponectin plays a protective role in caerulein-induced acute pancreatitis in mice fed a high-fat diet

H. Araki, T. Nishihara, M. Matsuda, A. Fukuhara, S. Kihara, T. Funahashi, T. R. Kataoka, Y. Kamada, T. Kiyohara, S. Tamura, N. Hayashi, I. Shimomura

GUT　Vol. 57　No. 10　p. 1431-1440　2008/10　Research paper (scientific journal)

[18F-fluorodeoxyglucose-positron emission tomography (FDG-PET) was useful tool for detecting tuberculous peritonitis: report of a case].

Yamamoto S, Nishida T, Tsutsui S, Yamamoto K, Yakushijin T, Igura T, Kamada Y, Wada A, Watabe K, Hayashi N

Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology　Vol. 105　No. 10　p. 1515-1522　2008/10

Adipose tissue derived stromal cell(ADSC)を用いた肝再生療法開発へ向けた検討

鎌田佳宏, 木曽真一, 佐治雪子, 吉田雄一, 松本 仁, 福島寿一, 江崎久男, 竹村貴代, 和田 朗, 井倉 技, 田村信司, 林 紀夫

2008/06　Research paper (other academic)

adipose tissue derived stromal cell(ADSC)を用いた肝再生療法開発へ向けた検討

鎌田佳宏, 吉田雄一, 佐治雪子, 松本 仁, 福島寿一, 江崎久男, 竹村貴代, 和田 朗, 井倉 技, 田村信司, 木曽真一, 林 紀夫

2008/05　Research paper (other academic)

NASH進展に対するアディポネクチンの意義

鎌田佳宏, 木曽真一, 林 紀夫

2008/05　Research paper (other academic)

アディポネクチンとNASH

鎌田佳宏, 林 紀夫

NASH診療best approach　2008/04

アディポネクチンと細胞増殖・アポトーシス

鎌田佳宏, 田村信司, 林 紀夫

アディポネクチンとその受容体　2008/04

PPARと肝疾患

鎌田佳宏, 辻井正彦, 林 紀夫

炎症と免疫　2008/04

アディポサイトカインとNASH

鎌田佳宏, 林 紀夫

最新医学　2008/04

肝線維化、発癌におけるアディポネクチンの意義

鎌田佳宏, 田村信司, 林 紀夫

2007/12　Research paper (other academic)

Murine adipose tissue derived stromal cells trans-differentiate into hepatic lineage cells by basic fibroblast growth factor

Yoshihiro Kamada

Hepatology　2007/11　Research paper (scientific journal)

Expression of Rab5a in hepatocellular carcinoma: Possible involvement in epidermal growth factor signaling

Koji Fukui, Shinji Tamura, Akira Wada, Yoshihiro Kamada, Takumi Igura, Shinichi Kiso, Norio Hayashi

HEPATOLOGY RESEARCH　Vol. 37　No. 11　p. 957-965　2007/11　Research paper (scientific journal)

Expression of Rab5a in hepatocellular carcinoma: Possible involvement in epidermal growth factor signaling

Koji Fukui, Shinji Tamura, Akira Wada, Yoshihiro Kamada, Takumi Igura, Shinichi Kiso, Norio Hayashi

HEPATOLOGY RESEARCH　Vol. 37　No. 11　p. 957-965　2007/11　Research paper (scientific journal)

Adipose tissue derived stromal cell (ADSC)から肝細胞様細胞への分化誘導

鎌田佳宏, 田村信司, 林 紀夫

2007/10　Research paper (other academic)

Hypoadiponectinemia accelerates hepatic tumor formation in a nonalcoholic steatohepatitis mouse model

Yoshihiro Kamada, Hitoshi Matsumoto, Shinji Tamura, Juichi Fukushima, Shinichi Kiso, Koji Fukui, Takumi Igura, Norikazu Maeda, Shinji Kihara, Tohru Funahashi, Yuji Matsuzawa, Lichiro Shimomura, Norio Hayashi

JOURNAL OF HEPATOLOGY　Vol. 47　No. 4　p. 556-564　2007/10　Research paper (scientific journal)

Hypoadiponectinemia accelerates hepatic tumor formation in a nonalcoholic steatohepatitis mouse model

Yoshihiro Kamada, Hitoshi Matsumoto, Shinji Tamura, Juichi Fukushima, Shinichi Kiso, Koji Fukui, Takumi Igura, Norikazu Maeda, Shinji Kihara, Tohru Funahashi, Yuji Matsuzawa, Lichiro Shimomura, Norio Hayashi

JOURNAL OF HEPATOLOGY　Vol. 47　No. 4　p. 556-564　2007/10　Research paper (scientific journal)

Adipose tissue derived stromal cell (ADSC)の肝細胞様細胞への分化誘導

鎌田佳宏, 田村信司, 林 紀夫

2007/05　Research paper (other academic)

メタボリックシンドロームにおける肝障害とアディポネクチンの関係

鎌田佳宏, 田村信司, 林 紀夫

2007/04　Research paper (other academic)

解説NAFLD/NASHの発症機構

鎌田佳宏, 田村信司

総合臨床　2007/04

NASHの病態について

鎌田佳宏, 田村信司, 林 紀夫

クリニシアン　2007/04

アルコール性肝障害

鎌田佳宏

消化器疾患治療マニュアル　2007/04

血液検査所見

鎌田佳宏, 田村信司

NASH診療ガイドブック　2007/04

肥満者における肝障害に対する低アディポネクチン血症の意義

鎌田佳宏, 田村信司, 林 紀夫

2006/10　Research paper (other academic)

Expression and prognostic role of RhoA GTPases in hepatocellular carcinoma

Koji Fukui, Shinji Tamura, Akira Wada, Yoshihiro Kamada, Yoshiyuki Sawai, Kazuho Imanaka, Takahiko Kudara, Iichiro Shimomura, Norio Hayashi

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY　Vol. 132　No. 10　p. 627-633　2006/10　Research paper (scientific journal)

Expression and prognostic role of RhoA GTPases in hepatocellular carcinoma

Koji Fukui, Shinji Tamura, Akira Wada, Yoshihiro Kamada, Yoshiyuki Sawai, Kazuho Imanaka, Takahiko Kudara, Iichiro Shimomura, Norio Hayashi

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY　Vol. 132　No. 10　p. 627-633　2006/10　Research paper (scientific journal)

Adiponectin deficiency exacerbates lipopolysaccharide/D-galactosamine-induced liver injury in mice

Hitoshi Matsumoto, Shinji Tamura, Yoshihiro Kamada, Shinichi Kiso, Juichi Fukushima, Akira Wada, Norikazu Maeda, Shinji Kihara, Tohru Funahashi, Yuji Matsuzawa, Iichiro Shimomura, Norio Hayashi

WORLD JOURNAL OF GASTROENTEROLOGY　Vol. 12　No. 21　p. 3352-3358　2006/06　Research paper (scientific journal)

Identification of amino-terminal region of adiponectin as a physiologically functional domain

H Ujiie, K Oritani, H Kato, T Yokota, Takahashi, I, T Maeda, H Masaie, M Ichii, Y Kamada, S Tamura, S Kihara, T Funahashi, Y Tomiyama, Y Kanakura

JOURNAL OF CELLULAR BIOCHEMISTRY　Vol. 98　No. 1　p. 194-207　2006/05　Research paper (scientific journal)

Identification of amino-terminal region of adiponectin as a physiologically functional domain

H Ujiie, K Oritani, H Kato, T Yokota, Takahashi, I, T Maeda, H Masaie, M Ichii, Y Kamada, S Tamura, S Kihara, T Funahashi, Y Tomiyama, Y Kanakura

JOURNAL OF CELLULAR BIOCHEMISTRY　Vol. 98　No. 1　p. 194-207　2006/05　Research paper (scientific journal)

アディポネクチンの肝線維化に対する抑制作用

鎌田佳宏, 田村信司, 松本 仁, 佐治雪子, 木曽真一, 福井浩司, 前田法一, 木原進士

2006/04　Research paper (other academic)

Adiponectin deficiency exacerbates lipopolysaccharide/D-galactosamine-induced liver injury in mice.

Matsumoto H, Tamura S, Kamada Y, Kiso S, Fukushima J, Wada A, Maeda N, Kihara S, Funahashi T, Matsuzawa Y, Shimomura I, Hayashi N

World J Gastroenterol　2006/04　Research paper (scientific journal)

Lack of adiponectin enhanced oxidative stress in a mice NASH model

Yoshihiro Kamada

Hepatology　2006　Research paper (scientific journal)

Lack of adiponectin, an adipocytokine, enhanced the progression of non-alcoholic steatohepatitis (NASH)

Yoshihiro Kamada

Hepatology　2005/11　Research paper (scientific journal)

酸化ストレスによるNASHからの発癌に対するアディポネクチンの作用

松本 仁, 田村信司, 鎌田佳宏, 福島寿一, 佐治雪子, 木曽真一, 福井浩司, 前田法一, 木原進士, 篠村恭久, 船橋 徹, 松澤佑次, 下村伊一郎

2005/10　Research paper (other academic)

NASH進展におけるアディポネクチンの意義について～酸化ストレスに着目して

福島寿一, 鎌田佳宏, 田村信司, 松本 仁, 佐治雪子, 江崎久男, 福井浩司, 木曽真一, 船橋 徹, 下村伊一郎, 林 紀夫

2005/06　Research paper (other academic)

Non-alcoholic steatohepatitis (NASH)におけるアディポネクチンの意義について

鎌田佳宏, 田村信司, 松本 仁, 福島寿一, 佐治雪子, 木曽真一, 福井浩司, 前田法一, 木原進士, 宮川潤一郎, 篠村恭久, 船橋 徹, 松澤佑次, 下村伊一郎

2005/06　Research paper (other academic)

Effects of growth factors on the growth and differentiation of mouse fetal liver epithelial cells in primary cultures

T Kawasaki, S Tamura, S Kiso, Y Doi, Y Yoshida, Y Kamada, A Saeki, Y Saji, Y Matsuzawa

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY　Vol. 20　No. 6　p. 857-864　2005/06　Research paper (scientific journal)

Effects of growth factors on the growth and differentiation of mouse fetal liver epithelial cells in primary cultures

T Kawasaki, S Tamura, S Kiso, Y Doi, Y Yoshida, Y Kamada, A Saeki, Y Saji, Y Matsuzawa

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY　Vol. 20　No. 6　p. 857-864　2005/06　Research paper (scientific journal)

non-alcoholic steatohepatitis(NASH)におけるアディポネクチンの意義

鎌田佳宏, 田村信司, 松本 仁, 木曽真一, 篠村恭久, 船橋 徹, 松澤佑次, 下村伊一郎

2005/04　Research paper (other academic)

Multilobular neurilemmoma of the tongue in a child.

Nakasato T, Kamada Y, Ehara S, Miura Y

AJNR. American journal of neuroradiology　Vol. 26　No. 2　p. 421-423　2005/02

Basic fibroblast growth factor promotes the trans-differentiation of mouse bone marrow cells into hepatic lineage cells via multiple liver-enriched transcription factors

Y Saji, S Tamura, Y Yoshida, S Kiso, AS Iizuka, H Matsumoto, T Kawasaki, Y Kamada, Y Matsuzawa, Y Shinomura

JOURNAL OF HEPATOLOGY　Vol. 41　No. 4　p. 545-550　2004/10　Research paper (scientific journal)

アディポネクチンの肝脂肪沈着、肝線維化、肝発癌抑制効果について

鎌田佳宏, 田村信司, 松本 仁, 佐治雪子, 木曽真一, 福井浩司, 前田法一, 木原進士, 宮川潤一郎, 篠村恭久, 船橋 徹, 松澤佑次

2004/06　Research paper (other academic)

adipocytokine, angiotensinと肝線維化

鎌田佳宏, 田村信司, 松澤佑次

肝疾患Review 2004　2004/04

Enhanced carbon tetrachloride-induced liver fibrosis in mice lacking adiponectin

Y Kamada, S Tamura, S Kiso, H Matsumoto, Y Saji, Y Yoshida, K Fukui, N Maeda, H Nishizawa, H Nagaretani, Y Okamoto, S Kihara, J Miyagawa, Y Shinomura, T Funahashi, Y Matsuzawa

GASTROENTEROLOGY　Vol. 125　No. 6　p. 1796-1807　2003/12　Research paper (scientific journal)

Adiponectin, an adipocytokine, attenuates carbon-tetrachloride induced liver fibrosis in mice

Yoshihiro Kamada

Hepatology　2003/11　Research paper (scientific journal)

肝臓におけるアディポネクチンの作用について

鎌田佳宏, 田村信司, 松本 仁, 佐治雪子, 木曽真一, 吉田雄一, 福井浩司, 前田法一, 木原進士, 宮川潤一郎, 船橋 徹, 篠村恭久, 松澤佑次

2003/10　Research paper (other academic)

アルギニン欠乏状態における血管内皮機能異常

鎌田佳宏, 田村信司, 山下静也, 松澤佑次

The Lipid　2003/07

Angiotensin II stimulates the nuclear translocation of Smad2 and induces PAI-1 mRNA in rat hepatic stellate cells

Yoshihiro Kamada, Shinji Tamura, Shinichi Kiso, Koji Fukui, Yoshinori Doi, Nobuyuki Ito, Yuki Terui, Takafumi Saito, Hisayoshi Watanabe, Hitoshi Togashi, Sumio Kawata, Yuji Matsuzawa

Hepatology Research　Vol. 25　No. 3　p. 296-305　2003/03/01　Research paper (scientific journal)

Angiotensin II stimulates the nuclear translocation of Smad2 and induces PAI-I mRNA in rat hepatic stellate cells

Y Kamada, S Tamura, S Kiso, K Fukui, Y Doi, N Ito, Y Terui, T Saito, H Watanabe, H Togashi, S Kawata, Y Matsuzawa

HEPATOLOGY RESEARCH　Vol. 25　No. 3　p. 296-305　2003/03　Research paper (scientific journal)

Basic fibroblast growth factor promotes trans-differentiation of murine bone marrow cells into hepatic linage cells via multiple liver-enriched transcription factors

Yoshihiro Kamada

Hepatology　Vol. 41　No. 4　2003　Research paper (scientific journal)

Enhanced Carbon Tetrachloride-Induced Liver Fibrosis in Mice Lacking Adiponectin

Yoshihiro Kamada, Shinji Tamura, Shinichi Kiso, Hitoshi Matsumoto, Yukiko Saji, Yuichi Yoshida, Koji Fukui, Norikazu Maeda, Hitoshi Nishizawa, Hiroyuki Nagaretani, Yoshihisa Okamoto, Shinji Kihara, Jun-Ihiro Miyagawa, Yasuhisa Shinomura, Tohru Funahashi, Yuji Matsuzawa

Gastroenterology　Vol. 125　No. 6　p. 1796-1807　2003　Research paper (scientific journal)

Adiponectin, an adipocyte-derived hormone, suppressed the proliferation, migration, and expression of genes involved in hepatic fibrosis of hepatic stellate cells

Yoshihiro Kamada

Hepatology　2002/11　Research paper (scientific journal)

脂肪細胞特異的蛋白質アディポネクチンの肝線維化に対する抑制作用

鎌田佳宏, 田村信司, 松澤佑次

2002/10　Research paper (other academic)

Effect of angiotensin receptor antagonist on liver fibrosis in early stages of chronic hepatitis C

Y Terui, T Saito, H Watanabe, H Togashi, S Kawata, Y Kamada, S Sakuta

HEPATOLOGY　Vol. 36　No. 4　p. 1022-1022　2002/10　Research paper (scientific journal)

Effect of angiotensin receptor antagonist on liver fibrosis in early stages of chronic hepatitis C

Y Terui, T Saito, H Watanabe, H Togashi, S Kawata, Y Kamada, S Sakuta

HEPATOLOGY　Vol. 36　No. 4　p. 1022-1022　2002/10

Angiotensin II induces TGF-beta 1 mRNA in rat hepatic stellate cells: The potential therapeutic effect of angiotensin II type 1 receptor blocker for hepatic fibrosis.

Y Kamada, S Tamura, S Kiso, K Fukui, Y Doi, N Ito, Y Terui, T Saito, H Watanabe, H Togashi, S Kawata, Y Matsuzawa

HEPATOLOGY　Vol. 34　No. 4　p. 400A-400A　2001/10　Research paper (scientific journal)

Vascular endothelial dysfunction resulting from L-arginine deficiency in a patient with lysinuric protein intolerance

Y Kamada, H Nagaretani, S Tamura, T Ohama, T Maruyama, H Hiraoka, S Yamashita, A Yamada, S Kiso, Y Inui, N Ito, Y Kayanoki, S Kawata, Y Matsuzawa

JOURNAL OF CLINICAL INVESTIGATION　Vol. 108　No. 5　p. 717-724　2001/09　Research paper (scientific journal)

Vascular endothelial dysfunction resulting from L-arginine deficiency in a patient with lysinuric protein intolerance

Yoshihiro Kamada, Hiroyuki Nagaretani, Shinji Tamura, Tohru Ohama, Takao Maruyama, Hisatoyo Hiraoka, Shizuya Yamashita, Akira Yamada, Shinichi Kiso, Yoshiaki Inui, Nobuyuki Ito, Yoshiro Kayanoki, Sumio Kawata, Yuji Matsuzawa

Journal of Clinical Investigation　Vol. 108　No. 5　p. 717-724　2001　Research paper (scientific journal)

新しいNO産生低下による病態～リジン尿性蛋白不耐症の病態について

鎌田佳宏, 田村信司, 河田純男

BIO clinica　2000/12

A case with prolactinoma treated with pergolide and its histology

Y Kamada, H Nakajima, Y Saitoh, K Yamamoto, Y Kawarada, N Arita, L Miyagawa, M Namba, T Hanafusa, T Sugiyama, T Hayakawa, Y Matsuzawa

ENDOCRINE JOURNAL　Vol. 45　No. 4　p. 605-606　1998/08

A case with prolactinoma treated with pergolide and its histology

Y. Kamada, H. Nakajima, Y. Saitoh, K. Yamamoto, Y. Kawarada, N. Arita, J. I. Miyagawa, M. Namba, T. Hanafusa, T. Sugiyama, T. Hayakawa, Y. Matsuzawa

Endocrine Journal　Vol. 45　No. 4　p. 605-606　1998　Research paper (scientific journal)

A case report of adenosquamous carcinoma of the liver with hepatolithiasis.

Horiuchi, T., Sakaguchi, M., Oka, S., Yamamoto, S., Kamada, Y., Tanaka, S., Tabuse, K.

The Japanese Journal of Gastroenterological Surgery　Vol. 24　No. 3　1991　Research paper (scientific journal)

A case of repeated massive bleeding from leiomyoblastoma of the stomach

Horiucih, T., Tsuji, T., Sakaguchi, M., Oka, S., Yamamoto, S., Morimoto, G., Kamada, Y., Tanaka, S., Sakatani, K.

Japanese Journal of National Medical Services　Vol. 42　No. 7　1988　Research paper (scientific journal)

FIB-4 First in Diagnostic Algorithm of MAFLD at the Era of “Global Metabodemic “

Yoshihiro Kamada