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A genome-scale metabolic model of a globally disseminated hyperinvasive M1 strain of Streptococcus pyogenes.
Hirose Y, Zielinski DC, Poudel S, Rychel K, Baker JL, Toya Y, Yamaguchi M, Heinken A, Thiele I, Kawabata S, Palsson BO, Nizet V
mSystems 2024年7月 研究論文（学術雑誌）
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Elucidation of independently modulated genes in Streptococcus pyogenes reveals carbon sources that control its expression of hemolytic toxins.
Yujiro Hirose, Saugat Poudel, Anand V Sastry, Kevin Rychel, Cameron R Lamoureux, Richard Szubin, Daniel C Zielinski, Hyun Gyu Lim, Nitasha D Menon, Helena Bergsten, Satoshi Uchiyama, Tomoki Hanada, Shigetada Kawabata, Bernhard O Palsson, Victor Nizet
mSystems Vol. 8 No. 3 2023年6月29日 研究論文（学術雑誌）
出版者・発行元：American Society for Microbiology
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Contribution of Streptococcus pyogenes M87 protein to innate immune resistance and virulence.
Yujiro Hirose, Piotr Kolesinski, Masanobu Hiraoka, Satoshi Uchiyama, Raymond H Zurich, Monika Kumaraswamy, Elisabet Bjanes, Partho Ghosh, Shigetada Kawabata, Victor Nizet
Microbial pathogenesis Vol. 169 p. 105636-105636 2022年6月17日 研究論文（学術雑誌）
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Streptococcus pyogenes upregulates arginine catabolism to exert its pathogenesis on the skin surface.
Yujiro Hirose, Masaya Yamaguchi, Tomoko Sumitomo, Masanobu Nakata, Tomoki Hanada, Daisuke Okuzaki, Daisuke Motooka, Yasushi Mori, Hiroshi Kawasaki, Alison Coady, Satoshi Uchiyama, Masanobu Hiraoka, Raymond H Zurich, Masayuki Amagai, Victor Nizet, Shigetada Kawabata
Cell reports Vol. 34 No. 13 p. 108924-108924 2021年3月30日 研究論文（学術雑誌）
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Genetic characterization of Streptococcus pyogenes emm89 strains isolated in Japan from 2011 to 2019
Hirose Y, Yamaguchi M, Takemoto N, Miyoshi-Akiyama T, Sumitomo T, Nakata M, Ikebe T, Hanada T, Yamaguchi T, Kawahara R, Okuno R, Otsuka H, Matsumoto Y, Terashima Y, Kazawa Y, Nakanishi N, Uchida K, Akiyama Y, Iwabuchi K, Nakagawa C, Yamamoto K, Nizet V, Kawabata S
Infect Microbe Dis. 2020年11月
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Streptococcus pyogenes transcriptome changes in the inflammatory environment of necrotizing fasciitis
Yujiro Hirose, Masaya Yamaguchi, Daisuke Okuzaki, Daisuke Motooka, Hiroshi Hamamoto, Tomoki Hanada, Tomoko Sumitomo, Masanobu Nakata, Shigetada Kawabata
Applied and Environmental Microbiology Vol. 85 No. 21 2019年11月1日 研究論文（学術雑誌）
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Comparison of trophic factors secreted from human adipose-derived stromal vascular fraction with those from adipose-derived stromal/stem cells in the same individuals
Yujiro Hirose, Yasuhito Funahashi, Yoshihisa Matsukawa, Tsuyoshi Majima, Masaya Yamaguchi, Shigetada Kawabata, Momokazu Gotoh, Tokunori Yamamoto
Cytotherapy Vol. 20 No. 4 p. 589-591 2018年4月1日
出版者・発行元：Elsevier B.V.
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Competence-induced protein Ccs4 facilitates pneumococcal invasion into brain tissue and virulence in meningitis.
Hirose Y, Yamaguchi M, Goto K, Sumitomo T, Nakata M, Kawabata S
Virulence Vol. 9 No. 1 p. 1576-1587 2018年
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Effects of Extracellular pH on Dental Pulp Cells In Vitro.
Hirose Y, Yamaguchi M, Kawabata S, Murakami M, Nakashima M, Gotoh M, Yamamoto T
Journal of endodontics Vol. 42 No. 5 p. 735-741 2016年5月 研究論文（学術雑誌）
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Injection of Dental Pulp Stem Cells Promotes Healing of Damaged Bladder Tissue in a Rat Model of Chemically Induced Cystitis
Yujiro Hirose, Tokunori Yamamoto, Misako Nakashima, Yasuhito Funahashi, Yoshihisa Matsukawa, Masaya Yamaguehi, Shigetada Kawabata, Momokazu Gotoh
CELL TRANSPLANTATION Vol. 25 No. 3 p. 425-436 2016年 研究論文（学術雑誌）
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GAS‐J, a User‐Friendly Browser Application for Genome Assembly, emm‐Typing, MLST Typing, and Virulence Factor Gene Detection of Streptococcus pyogenes
Norihiko Takemoto, Kohei Ogura, Yuan Gao, Rumi Okuno, Masaya Yamaguchi, Yujiro Hirose, Masayuki Ono, Shigetada Kawabata, Tadayoshi Ikebe, Takashi Hamabata, Tohru Miyoshi‐Akiyama
Microbiology and Immunology 2025年4月20日 研究論文（学術雑誌）
出版者・発行元：Wiley
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A comprehensive analysis of antimicrobial resistance of clinical emm89 Streptococcus pyogenes in Japan.
Weichen Gong, Masayuki Ono, Masaya Yamaguchi, Daisuke Motooka, Yujiro Hirose, Kotaro Higashi, Momoko Kobayashi, Eri Ikeda, Tomoko Sumitomo, Rumi Okuno, Takahiro Yamaguchi, Ryuji Kawahara, Hitoshi Otsuka, Noriko Nakanishi, Yu Kazawa, Chikara Nakagawa, Ryo Yamaguchi, Hiroo Sakai, Yuko Matsumoto, Tadayoshi Ikebe, Shigetada Kawabata
JAC-antimicrobial resistance Vol. 7 No. 1 2025年2月 研究論文（学術雑誌）
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Streptococcus pneumoniaeのモジュロン同定とRNA-seq解析への応用
広瀬 雄二郎, 池田 恵莉, 大野 誠之, 山口 雅也, 川端 重忠
Journal of Oral Biosciences Supplement Vol. 2024 p. [P3-02] 2024年11月
出版者・発行元：(一社)歯科基礎医学会
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Pneumolysin contributes to dysfunction of nasal epithelial barrier for promotion of pneumococcal dissemination into brain tissue
Yuki Takahara, Tomoko Sumitomo, Masamitsu Kono, Moe Takemura, Yukako Akamatsu, Yujiro Hirose, Masaya Yamaguchi, Masanobu Nakata, Muneki Hotomi, Shigetada Kawabata
mSphere 2024年9月30日 研究論文（学術雑誌）
出版者・発行元：American Society for Microbiology
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Identifying Genetic Variations inemm89Streptococcus pyogenesLinked to Severe Invasive Infections
Masayuki Ono, Masaya Yamaguchi, Daisuke Motooka, Yujiro Hirose, Kotaro Higashi, Tomoko Sumitomo, Tohru Miyoshi-Akiyama, Rumi Okuno, Takahiro Yamaguchi, Ryuji Kawahara, Hitoshi Otsuka, Noriko Nakanishi, Yu Kazawa, Chikara Nakagawa, Ryo Yamaguchi, Hiroo Sakai, Yuko Matsumoto, Tadayoshi Ikebe, Shigetada Kawabata
2024年7月2日
出版者・発行元：Cold Spring Harbor Laboratory
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トランスクリプトーム解析データを基にした肺炎球菌のモジュロンの同定
広瀬 雄二郎, 田渕 敏生, 池田 恵莉, 大野 誠之, 山口 雅也, 川端 重忠
日本細菌学雑誌 Vol. 79 No. 2 p. 141-141 2024年6月
出版者・発行元：日本細菌学会
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A genome-wide association study of emm89 Streptococcus pyogenes identifies genetic variations contributing to severe invasive infections
Masayuki Ono, Masaya Yamaguchi, Daisuke Motooka, Yujiro Hirose, Kotaro Higashi, Tomoko Sumitomo, Tohru Miyoshi-Akiyama, Rumi Okuno, Takahiro Yamaguchi, Ryuji Kawahara, Hitoshi Otsuka, Noriko Nakanishi, Yu Kazawa, Chikara Nakagawa, Ryo Yamaguchi, Hiroo Sakai, Yuko Matsumoto, Tadayoshi Ikebe, Shigetada Kawabata
2024年3月18日
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Independent component analysis reveals 49 independently modulated gene sets within the global transcriptional regulatory architecture of multidrug-resistant Acinetobacter baumannii
Nitasha D. Menon, Saugat Poudel, Anand V. Sastry, Kevin Rychel, Richard Szubin, Nicholas Dillon, Hannah Tsunemoto, Yujiro Hirose, Bipin G. Nair, Geetha B. Kumar, Bernhard O. Palsson, Victor Nizet
Vol. 9 No. 2 2024年2月20日 研究論文（学術雑誌）
出版者・発行元：
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Involvement of ribonuclease Y in pilus production by M49 Streptococcus pyogenes strain via modulation of messenger RNA level of transcriptional regulator.
Seiko Kubota, Masanobu Nakata, Yujiro Hirose, Masaya Yamaguchi, Bernd Kreikemeyer, Narikazu Uzawa, Tomoko Sumitomo, Shigetada Kawabata
Microbiology and immunology Vol. 67 No. 7 p. 319-333 2023年7月 研究論文（学術雑誌）
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侵襲性に関与するemm89型化膿レンサ球菌の因子の探索と分子生物学的解析
大野 誠之, 山口 雅也, 元岡 大祐, 広瀬 雄二郎, 東 孝太郎, 秋山 徹, 住友 倫子, 池辺 忠義, 奥野 ルミ, 川端 重忠
日本細菌学雑誌 Vol. 78 No. 1 p. 128-128 2023年2月
出版者・発行元：日本細菌学会
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Biological Evaluation of the Effect of Root Canal Sealers Using a Rat Model.
Motoki Okamoto, Sayako Matsumoto, Kiichi Moriyama, Hailing Huang, Masakatsu Watanabe, Jiro Miura, Keita Sugiyama, Yujiro Hirose, Manabu Mizuhira, Nanako Kuriki, Julian G Leprince, Yusuke Takahashi, Shigetada Kawabata, Mikako Hayashi
Pharmaceutics Vol. 14 No. 10 2022年9月24日 研究論文（学術雑誌）
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An M protein coiled coil unfurls and exposes its hydrophobic core to capture LL-37.
Piotr Kolesinski, Kuei-Chen Wang, Yujiro Hirose, Victor Nizet, Partho Ghosh
eLife Vol. 11 2022年6月21日 研究論文（学術雑誌）
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Pneumococcal BgaA Promotes Host Organ Bleeding and Coagulation in a Mouse Sepsis Model.
Moe Takemura, Masaya Yamaguchi, Momoko Kobayashi, Tomoko Sumitomo, Yujiro Hirose, Daisuke Okuzaki, Masayuki Ono, Daisuke Motooka, Kana Goto, Masanobu Nakata, Narikazu Uzawa, Shigetada Kawabata
Frontiers in cellular and infection microbiology Vol. 12 p. 844000-844000 2022年 研究論文（学術雑誌）
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病原因子と生態防御(感染モデル・寄生・免疫・ワクチン)/病原体と感染症 emm 89型化膿レンサ球菌による侵襲性感染症の発症因子の遺伝統計学的探索
大野 誠之, 山口 雅也, 広瀬 雄二郎, 東 孝太郎, 竹本 訓彦, 秋山 徹, 住友 倫子, 池辺 忠義, 川端 重忠
日本細菌学雑誌 Vol. 76 No. 1 p. 59-59 2021年2月
出版者・発行元：日本細菌学会
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ミャンマーで分離された肺炎球菌のシーケンス情報を用いた遺伝子プロファイリングとパンゲノム解析
山口 雅也, Hpoo Pwint Myo Win, 大野 誠之, 東 孝太郎, 広瀬 雄二郎, Mya Mya Aye, Moh Moh Htun, Hlaing Myat Thu, 川端 重忠
日本細菌学雑誌 Vol. 76 No. 1 p. 91-91 2021年2月
出版者・発行元：日本細菌学会
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Epidemiological analysis of pneumococcal strains isolated at Yangon Children's Hospital in Myanmar via whole-genome sequencing-based methods.
Masaya Yamaguchi, Hpoo Pwint Myo Win, Kotaro Higashi, Masayuki Ono, Yujiro Hirose, Daisuke Motooka, Daisuke Okuzaki, Mya Mya Aye, Moh Moh Htun, Hlaing Myat Thu, Shigetada Kawabata
Microbial genomics Vol. 7 No. 2 2021年2月 研究論文（学術雑誌）
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Streptococcal H2O2 inhibits IgE-triggered degranulation of RBL-2H3 mast cell/basophil cell line by inducing cell death
Nobuo Okahashi, Masanobu Nakata, Yujiro Hirose, Hirobumi Morisaki, Hideo Kataoka, Hirotaka Kuwata, Shigetada Kawabata
PLOS ONE Vol. 15 No. 4 p. e0231101-e0231101 2020年4月17日 研究論文（学術雑誌）
出版者・発行元：Public Library of Science (PLoS)
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Performance of a Biodegradable Composite with Hydroxyapatite as a Scaffold in Pulp Tissue Repair
Motoki Okamoto, Sayako Matsumoto, Ayato Sugiyama, Kei Kanie, Masakatsu Watanabe, Hailing Huang, Manahil Ali, Yuki Ito, Jiro Miura, Yujiro Hirose, Koichiro Uto, Mitsuhiro Ebara, Ryuji Kato, Aika Yamawaki-Ogata, Yuji Narita, Shigetada Kawabata, Yusuke Takahashi, Mikako Hayashi
Polymers Vol. 12 No. 4 p. 937-937 2020年4月17日 研究論文（学術雑誌）
出版者・発行元：MDPI AG
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Role of BgaA as a Pneumococcal Virulence Factor Elucidated by Molecular Evolutionary Analysis.
Masaya Yamaguchi, Moe Takemura, Kotaro Higashi, Kana Goto, Yujiro Hirose, Tomoko Sumitomo, Masanobu Nakata, Narikazu Uzawa, Shigetada Kawabata
Frontiers in microbiology Vol. 11 p. 582437-582437 2020年 研究論文（学術雑誌）
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Surface Pre-Reacted Glass Filler Contributes to Tertiary Dentin Formation through a Mechanism Different Than That of Hydraulic Calcium-Silicate Cement.
Motoki Okamoto, Manahil Ali, Shungo Komichi, Masakatsu Watanabe, Hailing Huang, Yuki Ito, Jiro Miura, Yujiro Hirose, Manabu Mizuhira, Yusuke Takahashi, Daisuke Okuzaki, Shigetada Kawabata, Satoshi Imazato, Mikako Hayashi
Journal of clinical medicine Vol. 8 No. 9 2019年9月11日 研究論文（学術雑誌）
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Identification of evolutionarily conserved virulence factor by selective pressure analysis of Streptococcus pneumoniae.
Yamaguchi M, Goto K, Hirose Y, Yamaguchi Y, Sumitomo T, Nakata M, Nakano K, Kawabata S
Communications biology Vol. 2 2019年
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Streptococcus pneumoniae Evades Host Cell Phagocytosis and Limits Host Mortality Through Its Cell Wall Anchoring Protein PfbA.
Yamaguchi M, Hirose Y, Takemura M, Ono M, Sumitomo T, Nakata M, Terao Y, Kawabata S
Frontiers in cellular and infection microbiology Vol. 9 2019年
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Composition of salivary microbiota in elderly subjects
Taiji Ogawa, Yujiro Hirose, Mariko Honda-Ogawa, Minami Sugimoto, Satoshi Sasaki, Masahito Kibi, Shigetada Kawabata, Kazunori Ikebe, Yoshinobu Maeda
Scientific Reports Vol. 8 No. 1 2018年12月1日 研究論文（学術雑誌）
出版者・発行元：Nature Publishing Group
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Zinc metalloproteinase ZmpC suppresses experimental pneumococcal meningitis by inhibiting bacterial invasion of central nervous systems
Masaya Yamaguchi, Masanobu Nakata, Ryuichi Sumioka, Yujiro Hirose, Satoshi Wada, Yukihiro Akeda, Tomoko Sumitomo, Shigetada Kawabata
VIRULENCE Vol. 8 No. 8 p. 1516-1524 2017年 研究論文（学術雑誌）
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Evolutionary inactivation of a sialidase in group B Streptococcus
Masaya Yamaguchi, Yujiro Hirose, Masanobu Nakata, Satoshi Uchiyama, Yuka Yamaguchi, Kana Goto, Tomoko Sumitomo, Amanda L. Lewis, Shigetada Kawabata, Victor Nizet
SCIENTIFIC REPORTS Vol. 6 2016年6月 研究論文（学術雑誌）
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Therapeutic Potential of Dental Pulp Stem Cell Secretome for Alzheimer's Disease Treatment: An In Vitro Study
Nermeen El-Moataz Bellah Ahmed, Masashi Murakami, Yujiro Hirose, Misako Nakashima
STEM CELLS INTERNATIONAL Vol. 2016 2016年 研究論文（学術雑誌）
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Trophic Effects and Regenerative Potential of Mobilized Mesenchymal Stem Cells From Bone Marrow and Adipose Tissue as Alternative Cell Sources for Pulp/Dentin Regeneration
Masashi Murakami, Yuki Hayashi, Koichiro Iohara, Yohei Osako, Yujiro Hirose, Misako Nakashima
CELL TRANSPLANTATION Vol. 24 No. 9 p. 1753-1765 2015年 研究論文（学術雑誌）
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Augmentation of regenerative potential of mesenchymal stem cells by granulocyte-colony stimulating factor (G-CSF) induced mobilization.
Hirose Y, Murakami M, Hayashi Y, Osako Y, Yamamoto T, Gotoh M, Nakashima M
J Stem Cell Res Transplant. Vol. 1 2014年
