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Hirose Yuujirou

廣瀨　雄二郎

Graduate School of Dentistry　Course for Oral Sciences, Associate Professor (Lecturer)

keyword Streptococci，Microbiology

Education

  • 2013/04 - 2016/03, Nagoya University Graduate School, Division of Medical Sciences
  • 2004/04 - 2010/03, Hokkaido University, Faculty of Dentistry

Research History

  • 2023/10 - Present, 大阪大学, 大学院歯学研究科 微生物学講座, 講師
  • 2022/09 - 2023/09, Osaka University
  • 2020/04 - 2022/08, University of California, San Diego
  • 2020/04 - 2022/08, 日本学術振興会, 海外特別研究員
  • 2017/04 - 2020/03, Osaka University, Graduate School of Dentistry, Specially Appointed Assistant Professor
  • 2016/04 - 2017/03, JSPS, Research Fellow, Postdoctoral Fellow (PD)
  • 2010/04 - 2013/03, HINODE DENTAL OFFICE, Dentist

Research Areas

  • Life sciences, Oral medicine (pathology), Immune · infection · inflammation
  • Life sciences, Oral medicine, Microbiology

Professional Memberships

  • The Japanese Association for Infectious Diseases
  • 米国微生物学会
  • 歯科基礎医学会
  • JAPANESE SOCIETY FOR BACTERIOLOGY

Papers

  • Elucidation of independently modulated genes in Streptococcus pyogenes reveals carbon sources that control its expression of hemolytic toxins., Yujiro Hirose,Saugat Poudel,Anand V Sastry,Kevin Rychel,Cameron R Lamoureux,Richard Szubin,Daniel C Zielinski,Hyun Gyu Lim,Nitasha D Menon,Helena Bergsten,Satoshi Uchiyama,Tomoki Hanada,Shigetada Kawabata,Bernhard O Palsson,Victor Nizet, mSystems, American Society for Microbiology, Vol. 8, No. 3, 2023/06/29
  • Contribution of Streptococcus pyogenes M87 protein to innate immune resistance and virulence., Yujiro Hirose,Piotr Kolesinski,Masanobu Hiraoka,Satoshi Uchiyama,Raymond H Zurich,Monika Kumaraswamy,Elisabet Bjanes,Partho Ghosh,Shigetada Kawabata,Victor Nizet, Microbial pathogenesis, Vol. 169, p. 105636-105636, 2022/06/17
  • Streptococcus pyogenes upregulates arginine catabolism to exert its pathogenesis on the skin surface., Yujiro Hirose,Masaya Yamaguchi,Tomoko Sumitomo,Masanobu Nakata,Tomoki Hanada,Daisuke Okuzaki,Daisuke Motooka,Yasushi Mori,Hiroshi Kawasaki,Alison Coady,Satoshi Uchiyama,Masanobu Hiraoka,Raymond H Zurich,Masayuki Amagai,Victor Nizet,Shigetada Kawabata, Cell reports, Vol. 34, No. 13, p. 108924-108924, 2021/03/30
  • Streptococcus pyogenes transcriptome changes in the inflammatory environment of necrotizing fasciitis, Yujiro Hirose,Masaya Yamaguchi,Daisuke Okuzaki,Daisuke Motooka,Hiroshi Hamamoto,Tomoki Hanada,Tomoko Sumitomo,Masanobu Nakata,Shigetada Kawabata, Applied and Environmental Microbiology, Vol. 85, No. 21, 2019/11/01
  • Competence-induced protein Ccs4 facilitates pneumococcal invasion into brain tissue and virulence in meningitis., Hirose Y,Yamaguchi M,Goto K,Sumitomo T,Nakata M,Kawabata S, Virulence, Vol. 9, No. 1, p. 1576-1587, 2018
  • Independent component analysis reveals 49 independently modulated gene sets within the global transcriptional regulatory architecture of multidrug-resistant <i>Acinetobacter baumannii</i>, Nitasha D. Menon,Saugat Poudel,Anand V. Sastry,Kevin Rychel,Richard Szubin,Nicholas Dillon,Hannah Tsunemoto,Yujiro Hirose,Bipin G. Nair,Geetha B. Kumar,Bernhard O. Palsson,Victor Nizet, mSystems, American Society for Microbiology, Vol. 9, No. 2, 2024/02/20
  • Involvement of ribonuclease Y in pilus production by M49 Streptococcus pyogenes strain via modulation of messenger RNA level of transcriptional regulator., Seiko Kubota,Masanobu Nakata,Yujiro Hirose,Masaya Yamaguchi,Bernd Kreikemeyer,Narikazu Uzawa,Tomoko Sumitomo,Shigetada Kawabata, Microbiology and immunology, Vol. 67, No. 7, p. 319-333, 2023/07
  • 侵襲性に関与するemm89型化膿レンサ球菌の因子の探索と分子生物学的解析, 大野 誠之,山口 雅也,元岡 大祐,広瀬 雄二郎,東 孝太郎,秋山 徹,住友 倫子,池辺 忠義,奥野 ルミ,川端 重忠, 日本細菌学雑誌, 日本細菌学会, Vol. 78, No. 1, p. 128-128, 2023/02
  • Biological Evaluation of the Effect of Root Canal Sealers Using a Rat Model., Motoki Okamoto,Sayako Matsumoto,Kiichi Moriyama,Hailing Huang,Masakatsu Watanabe,Jiro Miura,Keita Sugiyama,Yujiro Hirose,Manabu Mizuhira,Nanako Kuriki,Julian G Leprince,Yusuke Takahashi,Shigetada Kawabata,Mikako Hayashi, Pharmaceutics, Vol. 14, No. 10, 2022/09/24
  • An M protein coiled coil unfurls and exposes its hydrophobic core to capture LL-37., Piotr Kolesinski,Kuei-Chen Wang,Yujiro Hirose,Victor Nizet,Partho Ghosh, eLife, Vol. 11, 2022/06/21
  • Pneumococcal BgaA Promotes Host Organ Bleeding and Coagulation in a Mouse Sepsis Model., Moe Takemura,Masaya Yamaguchi,Momoko Kobayashi,Tomoko Sumitomo,Yujiro Hirose,Daisuke Okuzaki,Masayuki Ono,Daisuke Motooka,Kana Goto,Masanobu Nakata,Narikazu Uzawa,Shigetada Kawabata, Frontiers in cellular and infection microbiology, Vol. 12, p. 844000-844000, 2022
  • 病原因子と生態防御(感染モデル・寄生・免疫・ワクチン)/病原体と感染症 emm 89型化膿レンサ球菌による侵襲性感染症の発症因子の遺伝統計学的探索, 大野 誠之,山口 雅也,広瀬 雄二郎,東 孝太郎,竹本 訓彦,秋山 徹,住友 倫子,池辺 忠義,川端 重忠, 日本細菌学雑誌, 日本細菌学会, Vol. 76, No. 1, p. 59-59, 2021/02
  • ミャンマーで分離された肺炎球菌のシーケンス情報を用いた遺伝子プロファイリングとパンゲノム解析, 山口 雅也,Hpoo Pwint Myo Win,大野 誠之,東 孝太郎,広瀬 雄二郎,Mya Mya Aye,Moh Moh Htun,Hlaing Myat Thu,川端 重忠, 日本細菌学雑誌, 日本細菌学会, Vol. 76, No. 1, p. 91-91, 2021/02
  • Epidemiological analysis of pneumococcal strains isolated at Yangon Children's Hospital in Myanmar via whole-genome sequencing-based methods., Masaya Yamaguchi,Hpoo Pwint Myo Win,Kotaro Higashi,Masayuki Ono,Yujiro Hirose,Daisuke Motooka,Daisuke Okuzaki,Mya Mya Aye,Moh Moh Htun,Hlaing Myat Thu,Shigetada Kawabata, Microbial genomics, Vol. 7, No. 2, 2021/02
  • Genetic characterization of Streptococcus pyogenes emm89 strains isolated in Japan from 2011 to 2019, Hirose Y,Yamaguchi M,Takemoto N,Miyoshi-Akiyama T,Sumitomo T,Nakata M,Ikebe T,Hanada T,Yamaguchi T,Kawahara R,Okuno R,Otsuka H,Matsumoto Y,Terashima Y,Kazawa Y,Nakanishi N,Uchida K,Akiyama Y,Iwabuchi K,Nakagawa C,Yamamoto K,Nizet V,Kawabata S, Infect Microbe Dis., 2020/11
  • Streptococcal H2O2 inhibits IgE-triggered degranulation of RBL-2H3 mast cell/basophil cell line by inducing cell death, Nobuo Okahashi,Masanobu Nakata,Yujiro Hirose,Hirobumi Morisaki,Hideo Kataoka,Hirotaka Kuwata,Shigetada Kawabata, PLOS ONE, Public Library of Science (PLoS), Vol. 15, No. 4, p. e0231101-e0231101, 2020/04/17
  • Performance of a Biodegradable Composite with Hydroxyapatite as a Scaffold in Pulp Tissue Repair, Motoki Okamoto,Sayako Matsumoto,Ayato Sugiyama,Kei Kanie,Masakatsu Watanabe,Hailing Huang,Manahil Ali,Yuki Ito,Jiro Miura,Yujiro Hirose,Koichiro Uto,Mitsuhiro Ebara,Ryuji Kato,Aika Yamawaki-Ogata,Yuji Narita,Shigetada Kawabata,Yusuke Takahashi,Mikako Hayashi, Polymers, MDPI AG, Vol. 12, No. 4, p. 937-937, 2020/04/17
  • Role of BgaA as a Pneumococcal Virulence Factor Elucidated by Molecular Evolutionary Analysis., Masaya Yamaguchi,Moe Takemura,Kotaro Higashi,Kana Goto,Yujiro Hirose,Tomoko Sumitomo,Masanobu Nakata,Narikazu Uzawa,Shigetada Kawabata, Frontiers in microbiology, Vol. 11, p. 582437-582437, 2020
  • Surface Pre-Reacted Glass Filler Contributes to Tertiary Dentin Formation through a Mechanism Different Than That of Hydraulic Calcium-Silicate Cement., Motoki Okamoto,Manahil Ali,Shungo Komichi,Masakatsu Watanabe,Hailing Huang,Yuki Ito,Jiro Miura,Yujiro Hirose,Manabu Mizuhira,Yusuke Takahashi,Daisuke Okuzaki,Shigetada Kawabata,Satoshi Imazato,Mikako Hayashi, Journal of clinical medicine, Vol. 8, No. 9, 2019/09/11
  • Identification of evolutionarily conserved virulence factor by selective pressure analysis of <i>Streptococcus pneumoniae</i>., Yamaguchi M,Goto K,Hirose Y,Yamaguchi Y,Sumitomo T,Nakata M,Nakano K,Kawabata S, Communications biology, Vol. 2, 2019
  • <i>Streptococcus pneumoniae</i> Evades Host Cell Phagocytosis and Limits Host Mortality Through Its Cell Wall Anchoring Protein PfbA., Yamaguchi M,Hirose Y,Takemura M,Ono M,Sumitomo T,Nakata M,Terao Y,Kawabata S, Frontiers in cellular and infection microbiology, Vol. 9, 2019
  • Composition of salivary microbiota in elderly subjects, Taiji Ogawa,Yujiro Hirose,Mariko Honda-Ogawa,Minami Sugimoto,Satoshi Sasaki,Masahito Kibi,Shigetada Kawabata,Kazunori Ikebe,Yoshinobu Maeda, Scientific Reports, Nature Publishing Group, Vol. 8, No. 1, 2018/12/01
  • Comparison of trophic factors secreted from human adipose-derived stromal vascular fraction with those from adipose-derived stromal/stem cells in the same individuals, Yujiro Hirose,Yasuhito Funahashi,Yoshihisa Matsukawa,Tsuyoshi Majima,Masaya Yamaguchi,Shigetada Kawabata,Momokazu Gotoh,Tokunori Yamamoto, Cytotherapy, Elsevier B.V., Vol. 20, No. 4, p. 589-591, 2018/04/01
  • Zinc metalloproteinase ZmpC suppresses experimental pneumococcal meningitis by inhibiting bacterial invasion of central nervous systems, Masaya Yamaguchi,Masanobu Nakata,Ryuichi Sumioka,Yujiro Hirose,Satoshi Wada,Yukihiro Akeda,Tomoko Sumitomo,Shigetada Kawabata, VIRULENCE, TAYLOR & FRANCIS INC, Vol. 8, No. 8, p. 1516-1524, 2017
  • Evolutionary inactivation of a sialidase in group B Streptococcus, Masaya Yamaguchi,Yujiro Hirose,Masanobu Nakata,Satoshi Uchiyama,Yuka Yamaguchi,Kana Goto,Tomoko Sumitomo,Amanda L. Lewis,Shigetada Kawabata,Victor Nizet, SCIENTIFIC REPORTS, NATURE PUBLISHING GROUP, Vol. 6, 2016/06
  • Effects of Extracellular pH on Dental Pulp Cells In Vitro, Yujiro Hirose,Masaya Yamaguchi,Shigetada Kawabata,Masashi Murakami,Misako Nakashima,Momokazu Gotoh,Tokunori Yamamoto, JOURNAL OF ENDODONTICS, ELSEVIER SCIENCE INC, Vol. 42, No. 5, p. 735-741, 2016/05
  • Injection of Dental Pulp Stem Cells Promotes Healing of Damaged Bladder Tissue in a Rat Model of Chemically Induced Cystitis, Yujiro Hirose,Tokunori Yamamoto,Misako Nakashima,Yasuhito Funahashi,Yoshihisa Matsukawa,Masaya Yamaguehi,Shigetada Kawabata,Momokazu Gotoh, CELL TRANSPLANTATION, SAGE PUBLICATIONS INC, Vol. 25, No. 3, p. 425-436, 2016
  • Therapeutic Potential of Dental Pulp Stem Cell Secretome for Alzheimer's Disease Treatment: An In Vitro Study, Nermeen El-Moataz Bellah Ahmed,Masashi Murakami,Yujiro Hirose,Misako Nakashima, STEM CELLS INTERNATIONAL, HINDAWI LTD, Vol. 2016, 2016
  • Trophic Effects and Regenerative Potential of Mobilized Mesenchymal Stem Cells From Bone Marrow and Adipose Tissue as Alternative Cell Sources for Pulp/Dentin Regeneration, Masashi Murakami,Yuki Hayashi,Koichiro Iohara,Yohei Osako,Yujiro Hirose,Misako Nakashima, CELL TRANSPLANTATION, COGNIZANT COMMUNICATION CORP, Vol. 24, No. 9, p. 1753-1765, 2015
  • Augmentation of regenerative potential of mesenchymal stem cells by granulocyte-colony stimulating factor (G-CSF) induced mobilization., Hirose Y,Murakami M,Hayashi Y,Osako Y,Yamamoto T,Gotoh M,Nakashima M, J Stem Cell Res Transplant., Vol. 1, 2014

Misc.

  • Investigation of pathogenic mechanisms of invasive emm89 Streptococcus pyogenes infection with genome-wide k-mer association study, 大野誠之,大野誠之,山口雅也,広瀬雄二郎,東孝太郎,東孝太郎,秋山徹,住友倫子,池辺忠義,山口貴弘,河原隆二,奥野ルミ,大塚仁,松本裕子,賀澤優,中西典子,秋山由美,中川力,川端重忠, 日本分子生物学会年会プログラム・要旨集(Web), Vol. 44th, 2021
  • Oral microbiota and load to the consideration of health., Ogawa T,Hirose Y,Honda M, Medical Science Digest., Vol. 43, No. 4, p. 561-563, 2017/04

Awards

  • 第31回 北里柴三郎記念学術奨励賞, 広瀬 雄二郎, 日本感染症学会, 2023/04
  • The 60th Annual Meeting of Japanese Association for Oral Biology. MORITA Best Presentation Award., Yujiro Hirose, Japanese Association for Oral Biology, 2018/09
  • 平成27年度 岩垂育英会奨学生, 広瀬 雄二郎, 岩垂育英会, 2015/04

Presentations

  • Identification of pneumococcal modulons based on transcriptome datasets. トランスクリプトーム解析データを基にした肺炎球菌のモジュロンの同定, 広瀬 雄二郎,田渕 敏生,池田 恵莉,大野 誠之,山口 雅也,川端 重忠, 第97回日本細菌学会総会, 2024/08/07
  • 血清型M1型 化膿レンサ球菌のゲノムスケール代謝モデルの開発とその有用性の検討, 広瀬 雄二郎,山口 雅也,川端 重忠, 第98回日本感染症学会総会, 2024/06/27
  • 化膿レンサ球菌は皮膚病変の形成に皮膚組織由来のアルギニンを利用する, 広瀬 雄二郎, 学校法人北里研究所第33回学会賞受賞者特別講演会, 2024/01/29
  • 化膿レンサ球菌の血清型1型におけるモジュロンデータベースの紹介と活用法, 広瀬 雄二郎,川端 重忠, 第97回日本感染症学会総会, 2023/04/30
  • Streptococcus pyogenesのモジュロン情報は溶血活性を変化させる炭素源を明らかにする, 広瀬 雄二郎,Victor Nize,Bernhard O. Palsson,川端 重忠, 第96回日本細菌学会総会, 2023/03/16
  • UJA x ENGAGE-TF 留学のすゝめ2022, 広瀬 雄二郎, 第31 回 国際喘息学会日本・北アジア部会, 2022/11/25
  • Investigation of factors contributing to the invasiveness of Streptococcus pyogenes emm 89, Yujiro Hirose, 2020/02/19
  • 日本における劇症型感染症由来Streptococcus pyogenes emm 89型の解析, 広瀬 雄二郎, 第51回レンサ球菌研究会, 2019/06/21
  • 化膿レンサ球菌のアルギニン代謝系による病原因子の発現調節機構に関する解析, 広瀬 雄二郎, 歯科基礎医学会 2019年度 若手研究者助成 2次選考会, 2019/05/18
  • 化膿レンサ球菌のアルギニン代謝系は皮膚上で病原性発揮機構に寄与する, 広瀬 雄二郎,山口 雅也,住友 倫子,川端 重忠, 第93回日本感染症学会総会, 2019/04/06
  • Streptococcus pyogenes ArcA contributes to the expression of virulence factors under low glucose condition, Yujiro Hirose,Masaya Yamaguchi,Yasushi Mori,Kana Goto,Tomoko Sumitomo,Masanobu Nakata,Shigetada Kawabata, 60 th Japanese Association for Oral Biology, 2018/09/06
  • Streptococcus pyogenesが産生するArcAは皮膚病変形成に寄与する．, 広瀬 雄二郎,山口 雅也,毛利 泰士,後藤 花奈,住友 倫子,中田 匡宣,川端 重忠, 第91回日本細菌学会総会．, 2018/03/28
  • 歯髄幹細胞の泌尿器疾患への応用と，細胞外pHが歯髄幹細胞に与える影響, 広瀬 雄二郎, 岩垂育英会奨学金授与式, 2016/03/19

Committee Memberships

  • 大阪大学大学院歯学研究科, フロンティアセンター運営委員会委員, 2023/02 - Present
  • 大阪大学大学院歯学研究科, 微生物学講座 遺伝子組換え実験安全責任者, 2023/02 - Present
  • 大阪大学大学院歯学研究科, 病原体等安全管理委員会２号委員, 2023/02 - Present