Bi-allelic DNAH8 Variants Lead to Multiple Morphological Abnormalities of the Sperm Flagella and Primary Male Infertility

Chunyu Liu, Haruhiko Miyata, Yang Gao, Yanwei Sha, Shuyan Tang, Zoulan Xu, Marjorie Whitfield, Catherine Patrat, Huan Wu, Emmanuel Dulioust, Shixiong Tian, Keisuke Shimada, Jiangshan Cong, Taichi Noda, Hang Li, Akane Morohoshi, Caroline Cazin, Zine Eddine Kherraf, Christophe Arnoult, Li Jin, Xiaojin He, Pierre F. Ray, Yunxia Cao, Aminata Touré, Feng Zhang, Masahito Ikawa

American Journal of Human Genetics　Vol. 107　No. 2　p. 330-341　2020年8月6日　研究論文（学術雑誌）

NELL2-mediated lumicrine signaling through OVCH2 is required for male fertility

Daiji Kiyozumi, Taichi Noda, Ryo Yamaguchi, Tomohiro Tobita, Takafumi Matsumura, Kentaro Shimada, Mayo Kodani, Takashi Kohda, Yoshitaka Fujihara, Manabu Ozawa, Zhifeng Yu, Gabriella Miklossy, Kurt M. Bohren, Masato Horie, Masaru Okabe, Martin M. Matzuk, Masahito Ikawa

Science　Vol. 368　No. 6495　p. 1132-1135　2020年6月5日　研究論文（学術雑誌）

Sperm proteins SOF1, TMEM95, and SPACA6 are required for sperm-oocyte fusion in mice

Taichi Noda, Yonggang Lu, Yoshitaka Fujihara, Seiya Oura, Takayuki Koyano, Sumire Kobayashi, Martin M. Matzuk, Masahito Ikawa

Proceedings of the National Academy of Sciences of the United States of America　Vol. 117　No. 21　p. 11493-11502　2020年5月26日　研究論文（学術雑誌）

Spermatozoa lacking Fertilization Influencing Membrane Protein (FIMP) fail to fuse with oocytes in mice

Yoshitaka Fujihara, Yonggang Lu, Taichi Noda, Asami Oji, Tamara Larasati, Kanako Kojima-Kita, Zhifeng Yu, Ryan M. Matzuk, Martin M. Matzuk, Masahito Ikawa

Proceedings of the National Academy of Sciences of the United States of America　Vol. 117　No. 17　p. 9393-9400　2020年4月　研究論文（学術雑誌）

Identification of multiple male reproductive tractspecific proteins that regulate sperm migration through the oviduct in mice

Yoshitaka Fujihara, Taichi Noda, Kiyonori Kobayashi, Asami Oji, Sumire Kobayashi, Takafumi Matsumura, Tamara Larasati, Seiya Oura, Kanako Kojima-Kita, Zhifeng Yu, Martin M. Matzuk, Masahito Ikawa

Proceedings of the National Academy of Sciences of the United States of America　Vol. 116　No. 37　p. 18498-18506　2019年9月10日　研究論文（学術雑誌）

TCTE1 is a conserved component of the dynein regulatory complex and is required for motility and metabolism in mouse spermatozoa

Julio M. Castaneda, Rong Hua, Haruhiko Miyata, Asami Oji, Yueshuai Guo, Yiwei Cheng, Tao Zhou, Xuejiang Guo, Yiqiang Cui, Bin Shen, Zibin Wang, Zhibin Hu, Zuomin Zhou, Jiahao Sha, Renata Prunskaite-Hyyrylainen, Zhifeng Yu, Ramiro Ramirez-Solis, Masahito Ikawa, Martin M. Matzuk, Mingxi Liu

Proceedings of the National Academy of Sciences of the United States of America　Vol. 114　No. 27　p. E5370-E5378　2017年7月3日　研究論文（学術雑誌）

Genome engineering uncovers 54 evolutionarily conserved and testis-enriched genes that are not required for male fertility in mice

Haruhiko Miyata, Julio M. Castaneda, Yoshitaka Fujihara, Zhifeng Yu, Denise R. Archambeault, Ayako Isotani, Daiji Kiyozumi, Maya L. Kriseman, Daisuke Mashiko, Takafumi Matsumura, Ryan M. Matzuk, Masashi Mori, Taichi Noda, Asami Oji, Masaru Okabe, Renata Prunskaite-Hyyrylainen, Ramiro Ramirez-Solis, Yuhkoh Satouh, Qian Zhang, Masahito Ikawa, Martin M. Matzuk

Proceedings of the National Academy of Sciences of the United States of America　Vol. 113　No. 28　p. 7704-7710　2016年7月12日　研究論文（学術雑誌）

Sperm calcineurin inhibition prevents mouse fertility with implications for male contraceptive

Haruhiko Miyata, Yuhkoh Satouh, Daisuke Mashiko, Masanaga Muto, Kaori Nozawa, Kogiku Shiba, Yoshitaka Fujihara, Ayako Isotani, Kazuo Inaba, Masahito Ikawa

Science　Vol. 350　No. 6259　p. 442-445　2015年10月23日　研究論文（学術雑誌）

Expression of TEX101, regulated by ACE, is essential for the production of fertile mouse spermatozoa

Yoshitaka Fujihara, Keizo Tokuhiro, Yuko Muro, Gen Kondoh, Yoshihiko Araki, Masahito Ikawa, Masaru Okabe

Proceedings of the National Academy of Sciences of the United States of America　Vol. 110　No. 20　p. 8111-8116　2013年5月14日　研究論文（学術雑誌）

MiR-200b and miR-429 function in mouse ovulation and are essential for female fertility

Hidetoshi Hasuwa, Jun Ueda, Masahito Ikawa, Masaru Okabe

Science　Vol. 341　No. 6141　p. 71-73　2013年　研究論文（学術雑誌）

Protein disulfide isomerase homolog PDILT is required for quality control of sperm membrane protein ADAM3 and male infertility

Keizo Tokuhiro, Masahito Ikawa, Adam M. Benham, Masaru Okabe

Proceedings of the National Academy of Sciences of the United States of America　Vol. 109　No. 10　p. 3850-3855　2012年3月6日　研究論文（学術雑誌）

Pravastatin induces placental growth factor (PGF) and ameliorates preeclampsia in a mouse model

Keiichi Kumasawa, Masahito Ikawa, Hiroyasu Kidoya, Hidetoshi Hasuwa, Tomoko Saito-Fujita, Yuka Morioka, Nobuyuki Takakura, Tadashi Kimura, Masaru Okabe

Proceedings of the National Academy of Sciences of the United States of America　Vol. 108　No. 4　p. 1451-1455　2011年1月　研究論文（学術雑誌）

Fertilization: A sperm's journey to and interaction with the oocyte

Masahito Ikawa, Naokazu Inoue, Adam M. Benham, Masaru Okabe

Journal of Clinical Investigation　Vol. 120　No. 4　p. 984-994　2010年4月

Complementation of placental defects and embryonic lethality by trophoblast-specific lentiviral gene transfer

Yuka Okada, Yuko Ueshin, Ayako Isotani, Tomoko Saito-Fujita, Hisako Nakashima, Kazushi Kimura, Akira Mizoguchi, Masatsugu Oh-Hora, Yoshiko Mori, Masato Ogata, Robert G. Oshima, Masaru Okabe, Masahito Ikawa

Nature Biotechnology　Vol. 25　No. 2　p. 233-237　2007年2月　研究論文（学術雑誌）

Production of knockout mice by random or targeted mutagenesis in spermatogonial stem cells

Mito Kanatsu-Shinohara, Masahito Ikawa, Masanori Takehashi, Narumi Ogonuki, Hiromi Miki, Kimiko Inoue, Yasuhiro Kazuki, Jiyoung Lee, Shinya Toyokuni, Mitsuo Oshimura, Atsuo Ogura, Takashi Shinohara

Proceedings of the National Academy of Sciences of the United States of America　Vol. 103　No. 21　p. 8018-8023　2006年5月23日　研究論文（学術雑誌）

The immunoglobulin superfamily protein Izumo is required for sperm to fuse with eggs

Naokazu Inoue, Masahito Ikawa, Ayako Isotani, Masaru Okabe

Nature　Vol. 434　No. 7030　p. 234-238　2005年3月10日　研究論文（学術雑誌）

A general method for gene knockdown in mice by using lentiviral vectors expressing small interfering RNA

Gustavo Tiscornia, Oded Singer, Masahito Ikawa, Inder M. Verma

Proceedings of the National Academy of Sciences of the United States of America　Vol. 100　No. 4　p. 1844-1848　2003年2月18日　研究論文（学術雑誌）

Restoration of spermatogenesis by lentiviral gene transfer: Offspring from infertile mice

Masahito Ikawa, Vinay Tergaonkar, Atsuo Ogura, Narumi Ogonuki, Kimiko Inoue, Inder M. Verma

Proceedings of the National Academy of Sciences of the United States of America　Vol. 99　No. 11　p. 7524-7529　2002年5月28日　研究論文（学術雑誌）

Transgenesis by lentiviral vectors: Lack of gene silencing in mammalian embryonic stem cells and preimplantation embryos

Alexander Pfeifer, Masahito Ikawa, Yelena Dayn, Inder M. Verma

Proceedings of the National Academy of Sciences of the United States of America　Vol. 99　No. 4　p. 2140-2145　2002年2月19日　研究論文（学術雑誌）

The putative chaperone calmegin is required for sperm fertility

Masahito Ikawa, Ikuo Wada, Katsuya Kominami, Daisuke Watanabe, Kiyotaka Toshimori, Yoshitake Nishimune, Masaru Okabe

Nature　Vol. 387　No. 6633　p. 607-610　1997年6月5日　研究論文（学術雑誌）

Zinc is a Key Regulator of the Sperm-Specific K+ Channel (Slo3) Function

Rizki Tsari Andriani, Tanadet Pipatpolkai, Haruhiko Miyata, Masahito Ikawa, Yasushi Okamura, Takafumi Kawai

2025年4月2日

Heterozygous Tcf4 Deficiency Mitigates Fuchs Endothelial Corneal Dystrophy Progression in a Mouse Model.

Suguru Ito, Yuki Oyama, Taichi Yuasa, Koki Amano, Kotaro Onishi, Ayaka Izumi, Albert S Jun, Masahito Ikawa, Noriko Koizumi, Naoki Okumura

Investigative ophthalmology & visual science　Vol. 66　No. 4　p. 19-19　2025年4月1日　研究論文（学術雑誌）

Therapeutic Potential of Emricasan, a Pan-Caspase Inhibitor, in Reducing Cell Death and Extracellular Matrix Accumulation in Fuchs Endothelial Corneal Dystrophy.

Sohya Fujimoto, Mako Endo, Shigehito Tonomura, Fuuga Tsuji, Hirotaka Haraguchi, Kanna Hasegawa, Taisuke Numao, Ayaka Izumi, Theofilos Tourtas, Ursula Schlötzer-Schrehardt, Friedrich Kruse, Yuki Oyama, Masahito Ikawa, Albert S Jun, Noriko Koizumi, Naoki Okumura

Cells　Vol. 14　No. 7　2025年3月27日　研究論文（学術雑誌）

Retraction for Hiramatsu et al., "The Mechanism of Pertussis Cough Revealed by the Mouse-Coughing Model"

Yukihiro Hiramatsu, Koichiro Suzuki, Takashi Nishida, Naoki Onoda, Takashi Satoh, Shizuo Akira, Masahito Ikawa, Hiroko Ikeda, Junzo Kamei, Sandra Derouiche, Makoto Tominaga, Yasuhiko Horiguchi

mBio　Vol. 16　No. 3　2025年3月12日　研究論文（学術雑誌）

TEX38 localizes ZDHHC19 to the plasma membrane and regulates sperm head morphogenesis in mice.

Yuki Kaneda, Yonggang Lu, Jiang Sun, Keisuke Shimada, Chihiro Emori, Taichi Noda, Takayuki Koyano, Makoto Matsuyama, Haruhiko Miyata, Masahito Ikawa

Proceedings of the National Academy of Sciences of the United States of America　Vol. 122　No. 10　2025年3月11日　研究論文（学術雑誌）

Allosteric inhibition of the IZUMO1-JUNO fertilization complex by the naturally occurring antisperm antibody OBF13.

Yonggang Lu, Masahito Ikawa, Shaogeng Tang

Proceedings of the National Academy of Sciences of the United States of America　Vol. 122　No. 10　2025年3月11日　研究論文（学術雑誌）

Immunogenicity and safety of a live-attenuated SARS-CoV-2 vaccine candidate based on multiple attenuation mechanisms.

Mie Suzuki Okutani, Shinya Okamura, Tang Gis, Hitomi Sasaki, Suni Lee, Akiho Kashiwabara, Simon Goto, Mai Matsumoto, Mayuko Yamawaki, Toshiaki Miyazaki, Tatsuya Nakagawa, Masahito Ikawa, Wataru Kamitani, Shiro Takekawa, Koichi Yamanishi, Hirotaka Ebina

eLife　Vol. 13　2025年2月11日　研究論文（学術雑誌）

Loss of CCDC188 causes male infertility with defects in the sperm head-neck connection in mice†.

Yumiao Qiu, Keisuke Shimada, Kaito Yamamoto, Masahito Ikawa

Biology of reproduction　Vol. 112　No. 1　p. 169-178　2025年1月14日　研究論文（学術雑誌）

Trophectoderm-specific gene manipulation using adeno-associated viral vectors.

Tatsuya Nakagawa, Chihiro Emori, Masahito Ikawa

Experimental animals　2025年1月11日　研究論文（学術雑誌）

Development of the membrane ceiling method for in vitro spermatogenesis.

Maki Kamoshita, Hiroki Shirai, Hiroko Nakamura, Tetsuya Kishimoto, Yuki Hatanaka, Daisuke Mashiko, Katsuhiro Esashika, Jingjing Yang, Satoshi Yamasaki, Takehiko Ogawa, Hiroshi Kimura, Masahito Ikawa

Scientific reports　Vol. 15　No. 1　p. 625-625　2025年1月3日　研究論文（学術雑誌）

Intratesticular creatine maintains spermatogenesis by defining tight junctions.

Sohei Kuribayashi, Shinichiro Fukuhara, Hiroaki Kitakaze, Go Tsujimura, Takahiro Imanaka, Norichika Ueda, Kentaro Takezawa, Masahito Ikawa, Norio Nonomura

Scientific reports　Vol. 14　No. 1　p. 30692-30692　2024年12月28日　研究論文（学術雑誌）

Age-associated aberrations of the cumulus-oocyte interaction and in the zona pellucida structure reduce fertility in female mice.

Yu Ishikawa-Yamauchi, Chihiro Emori, Hideto Mori, Tsutomu Endo, Kiyonori Kobayashi, Yuji Watanabe, Hiroshi Sagara, Takeshi Nagata, Daisuke Motooka, Akinori Ninomiya, Manabu Ozawa, Masahito Ikawa

Communications biology　Vol. 7　No. 1　p. 1692-1692　2024年12月24日　研究論文（学術雑誌）

A conserved fertilization complex bridges sperm and egg in vertebrates.

Victoria E Deneke, Andreas Blaha, Yonggang Lu, Johannes P Suwita, Jonne M Draper, Clara S Phan, Karin Panser, Alexander Schleiffer, Laurine Jacob, Theresa Humer, Karel Stejskal, Gabriela Krssakova, Elisabeth Roitinger, Dominik Handler, Maki Kamoshita, Tyler D R Vance, Xinyin Wang, Joachim M Surm, Yehu Moran, Jeffrey E Lee, Masahito Ikawa, Andrea Pauli

Cell　Vol. 187　No. 25　p. 7066-7078　2024年12月12日　研究論文（学術雑誌）

Gelsolin alleviates rheumatoid arthritis by negatively regulating NLRP3 inflammasome activation.

Jiyeon Lee, Fumiyuki Sasaki, Eri Koike, Minjeong Cho, Yeongun Lee, So Hee Dho, Jina Lee, Eunji Lee, Eri Toyohara, Mika Sunakawa, Mariko Ishibashi, Huynh Hiep Hung, Saki Nishioka, Ritsuko Komine, Chiaki Okura, Masumi Shimizu, Masahito Ikawa, Akihiko Yoshimura, Rimpei Morita, Lark Kyun Kim

Cell death and differentiation　Vol. 31　No. 12　p. 1679-1694　2024年12月　研究論文（学術雑誌）

Spatiotemporal functions of leukemia inhibitory factor in embryo attachment and implantation chamber formation.

Shizu Aikawa, Takehiro Hiraoka, Mitsunori Matsuo, Yamato Fukui, Hidetoshi Fujita, Tomoko Saito-Fujita, Ryoko Shimizu-Hirota, Norihiko Takeda, Daiki Hiratsuka, Xueting He, Chihiro Ishizawa, Rei Iida, Shun Akaeda, Miyuki Harada, Osamu Wada-Hiraike, Masahito Ikawa, Yutaka Osuga, Yasushi Hirota

Cell death discovery　Vol. 10　No. 1　p. 481-481　2024年11月25日　研究論文（学術雑誌）

Inhibition of ROS1 activity with lorlatinib reversibly suppresses fertility in male mice.

Yuki Oyama, Kentaro Shimada, Haruhiko Miyata, Rie Iida-Norita, Chihiro Emori, Maki Kamoshita, Seiya Oura, Ryohei Katayama, Martin M Matzuk, Masahito Ikawa

Andrology　2024年11月20日　研究論文（学術雑誌）

Multiple lines of evidence for disruption of nuclear lamina and nucleoporins in FUS amyotrophic lateral sclerosis.

Kensuke Okada, Daisuke Ito, Satoru Morimoto, Chris Kato, Yuki Oguma, Hitoshi Warita, Naoki Suzuki, Masashi Aoki, Junko Kuramoto, Reona Kobayashi, Munehisa Shinozaki, Masahito Ikawa, Jin Nakahara, Shinichi Takahashi, Yoshinori Nishimoto, Shinsuke Shibata, Hideyuki Okano

Brain : a journal of neurology　Vol. 147　No. 11　p. 3933-3948　2024年11月4日　研究論文（学術雑誌）

USF2 and TFEB compete in regulating lysosomal and autophagy genes.

Jaebeom Kim, Young Suk Yu, Yehwa Choi, Do Hui Lee, Soobin Han, Junhee Kwon, Taichi Noda, Masahito Ikawa, Dongha Kim, Hyunkyung Kim, Andrea Ballabio, Keun Il Kim, Sung Hee Baek

Nature communications　Vol. 15　No. 1　p. 8334-8334　2024年9月27日　研究論文（学術雑誌）

Comprehensive posttranslational modifications in the testis-specific histone variant H3t protein validated in tagged knock-in mice.

Takayuki Kawaguchi, Michihiro Hashimoto, Reiko Nakagawa, Ryunosuke Minami, Masahito Ikawa, Jun-Ichi Nakayama, Jun Ueda

Scientific reports　Vol. 14　No. 1　p. 21305-21305　2024年9月12日　研究論文（学術雑誌）

Semaphorin 6D tunes amygdalar circuits for emotional, metabolic, and inflammatory outputs.

Yoshimitsu Nakanishi, Mayuko Izumi, Hiroaki Matsushita, Yoshihisa Koyama, Diego Diez, Hyota Takamatsu, Shohei Koyama, Masayuki Nishide, Maiko Naito, Yumiko Mizuno, Yuta Yamaguchi, Tomoki Mae, Yu Noda, Kamon Nakaya, Satoshi Nojima, Fuminori Sugihara, Daisuke Okuzaki, Masahito Ikawa, Shoichi Shimada, Sujin Kang, Atsushi Kumanogoh

Neuron　Vol. 112　No. 17　p. 2955-2972　2024年9月4日　研究論文（学術雑誌）

The significance of electrical signals in maturing spermatozoa for phosphoinositide regulation through voltage-sensing phosphatase.

Takafumi Kawai, Shin Morioka, Haruhiko Miyata, Rizki Tsari Andriani, Sharmin Akter, Gabriel Toma, Tatsuya Nakagawa, Yuki Oyama, Rie Iida-Norita, Junko Sasaki, Masahiko Watanabe, Kenji Sakimura, Masahito Ikawa, Takehiko Sasaki, Yasushi Okamura

Nature communications　Vol. 15　No. 1　p. 7289-7289　2024年8月24日　研究論文（学術雑誌）

FBXO24 deletion causes abnormal accumulation of membraneless electron-dense granules in sperm flagella and male infertility.

Yuki Kaneda, Haruhiko Miyata, Zoulan Xu, Keisuke Shimada, Maki Kamoshita, Tatsuya Nakagawa, Chihiro Emori, Masahito Ikawa

eLife　Vol. 13　2024年8月20日　研究論文（学術雑誌）

MYCBPAP is a central apparatus protein required for centrosome-nuclear envelope docking and sperm tail biogenesis in mice.

Haoting Wang, Hiroko Kobayashi, Keisuke Shimada, Seiya Oura, Yuki Oyama, Hiroaki Kitakaze, Taichi Noda, Norikazu Yabuta, Haruhiko Miyata, Masahito Ikawa

Journal of cell science　Vol. 137　No. 16　2024年8月15日　研究論文（学術雑誌）

Deep learning-based automated prediction of mouse seminiferous tubule stage by using bright-field microscopy

Yuta Tokuoka, Tsutomu Endo, Takashi Morikura, Yuki Hiradate, Masahito Ikawa, Akira Funahashi

2024年8月9日

Eighteen genes primarily expressed in the testis are not required for male fertility in mice.

Kaito Yamamoto, Yuki Hiradate, Masahito Ikawa

Biology of reproduction　Vol. 111　No. 5　p. 1071-1081　2024年8月6日　研究論文（学術雑誌）

Kdm4d mutant mice show impaired sperm motility and subfertility.

Zhuoran Xu, Yuka Fujimoto, Mizuki Sakamoto, Daiyu Ito, Masahito Ikawa, Takashi Ishiuchi

The Journal of reproduction and development　2024年7月22日　研究論文（学術雑誌）

Development of functional spermatozoa in mammalian spermiogenesis.

Haruhiko Miyata, Keisuke Shimada, Yuki Kaneda, Masahito Ikawa

Development (Cambridge, England)　Vol. 151　No. 14　2024年7月15日

Generation and characterization of cerebellar granule neurons specific knockout mice of Golli-MBP.

Haruko Miyazaki, Saki Nishioka, Tomoyuki Yamanaka, Manabu Abe, Yukio Imamura, Tomohiro Miyasaka, Nobuto Kakuda, Toshitaka Oohashi, Tomomi Shimogori, Kazuhiro Yamakawa, Masahito Ikawa, Nobuyuki Nukina

Transgenic research　Vol. 33　No. 3　p. 99-117　2024年6月1日　研究論文（学術雑誌）

Golgi associated RAB2 interactor protein family contributes to murine male fertility to various extents by assuring correct morphogenesis of sperm heads.

Haoting Wang, Rie Iida-Norita, Daisuke Mashiko, Anh Hoang Pham, Haruhiko Miyata, Masahito Ikawa

PLoS genetics　Vol. 20　No. 6　2024年6月1日　研究論文（学術雑誌）

Individual disruption of 12 testis-enriched genes via the CRISPR/Cas9 system does not affect the fertility of male mice.

Akira Suzuki, Norikazu Yabuta, Keisuke Shimada, Daisuke Mashiko, Keizo Tokuhiro, Yuki Oyama, Haruhiko Miyata, Thomas X Garcia, Martin M Matzuk, Masahito Ikawa

Journal of reproductive immunology　Vol. 163　p. 104252-104252　2024年6月1日　研究論文（学術雑誌）

Thirteen Ovary-Enriched Genes Are Individually Not Essential for Female Fertility in Mice.

Anh Hoang Pham, Chihiro Emori, Yu Ishikawa-Yamauchi, Keizo Tokuhiro, Maki Kamoshita, Yoshitaka Fujihara, Masahito Ikawa

Cells　Vol. 13　No. 10　2024年5月8日　研究論文（学術雑誌）

Gene-deficient mouse model established by CRISPR/Cas9 system reveals 15 reproductive organ-enriched genes dispensable for male fertility.

Tuyen Thi Thanh Nguyen, Keizo Tokuhiro, Keisuke Shimada, Haoting Wang, Daisuke Mashiko, Shingo Tonai, Daiji Kiyozumi, Masahito Ikawa

Frontiers in cell and developmental biology　Vol. 12　p. 1411162-1411162　2024年5月1日　研究論文（学術雑誌）

Threonine phosphorylation of STAT1 restricts interferon signaling and promotes innate inflammatory responses.

Hozaifa Metwally, Maha M Elbrashy, Tatsuhiko Ozawa, Kazuki Okuyama, Jason T White, Janyerkye Tulyeu, Jonas Nørskov Søndergaard, James Badger Wing, Arisa Muratsu, Hisatake Matsumoto, Masahito Ikawa, Hiroyuki Kishi, Ichiro Taniuchi, Tadamitsu Kishimoto

Proceedings of the National Academy of Sciences of the United States of America　Vol. 121　No. 17　2024年4月23日　研究論文（学術雑誌）

Conditional deficiency of Rho‐associated kinases disrupts endothelial cell junctions and impairs respiratory function in adult mice

Takahiro Akamine, Takeshi Terabayashi, Takako Sasaki, Riku Hayashi, Ichitaro Abe, Fumihiro Hirayama, Shin‐ichi Nureki, Masahito Ikawa, Haruhiko Miyata, Akinori Tokunaga, Takashi Kobayashi, Katsuhiro Hanada, Dean Thumkeo, Shuh Narumiya, Toshimasa Ishizaki

FEBS Open Bio　Vol. 14　No. 6　p. 906-921　2024年4月11日　研究論文（学術雑誌）

Multiple genes in the Pate5-13 genomic region contribute to ADAM3 processing†.

Taichi Noda, Hina Shinohara, Sumire Kobayashi, Ayumu Taira, Seiya Oura, Duri Tahara, Midori Tokuyasu, Kimi Araki, Masahito Ikawa

Biology of reproduction　Vol. 110　No. 4　p. 750-760　2024年4月11日　研究論文（学術雑誌）

Affinity-tagged SMAD1 and SMAD5 mouse lines reveal transcriptional reprogramming mechanisms during early pregnancy.

Zian Liao, Suni Tang, Kaori Nozawa, Keisuke Shimada, Masahito Ikawa, Diana Monsivais, Martin Matzuk

eLife　Vol. 12　2024年3月27日　研究論文（学術雑誌）

ZP2 cleavage blocks polyspermy by modulating the architecture of the egg coat.

Shunsuke Nishio, Chihiro Emori, Benjamin Wiseman, Dirk Fahrenkamp, Elisa Dioguardi, Sara Zamora-Caballero, Marcel Bokhove, Ling Han, Alena Stsiapanava, Blanca Algarra, Yonggang Lu, Mayo Kodani, Rachel E Bainbridge, Kayla M Komondor, Anne E Carlson, Michael Landreh, Daniele de Sanctis, Shigeki Yasumasu, Masahito Ikawa, Luca Jovine

Cell　Vol. 187　No. 6　p. 1440-1459　2024年3月14日　研究論文（学術雑誌）

Tex46 knockout male mice are sterile secondary to sperm head malformations and failure to penetrate through the zona pellucida.

Yoshitaka Fujihara, Haruhiko Miyata, Ferheen Abbasi, Tamara Larasati, Kaori Nozawa, Zhifeng Yu, Masahito Ikawa, Martin M Matzuk

PNAS nexus　Vol. 3　No. 3　2024年3月1日　研究論文（学術雑誌）

CUB domains are not required for OVCH2 function in sperm maturation in the mouse epididymis.

Katarzyna Kent, Kaori Nozawa, Courtney Sutton, Frey Daniel, Masahito Ikawa, Thomas X Garcia, Martin M Matzuk

Andrology　Vol. 12　No. 3　p. 682-697　2024年3月　研究論文（学術雑誌）

PABPN1L is required for maternal mRNA degradation after meiosis resumption.

Chihiro Emori, Mayo Kodani, Ferheen Abbasi, Masashi Mori, Masahito Ikawa

The Journal of reproduction and development　Vol. 70　No. 1　p. 10-17　2024年2月19日　研究論文（学術雑誌）

Disruption of testis-enriched cytochrome c oxidase subunit COX6B2 but not COX8C leads to subfertility.

Keisuke Shimada, Yonggang Lu, Masahito Ikawa

Experimental animals　Vol. 73　No. 1　p. 1-10　2024年2月14日　研究論文（学術雑誌）

Affinity-tagged SMAD1 and SMAD5 mouse lines reveal transcriptional reprogramming mechanisms during early pregnancy.

Zian Liao, Suni Tang, Kaori Nozawa, Keisuke Shimada, Masahito Ikawa, Diana Monsivais, Martin M Matzuk

bioRxiv : the preprint server for biology　2024年2月7日　研究論文（学術雑誌）

Multiple ageing effects on testicular/epididymal germ cells lead to decreased male fertility in mice.

Tsutomu Endo, Kiyonori Kobayashi, Takafumi Matsumura, Chihiro Emori, Manabu Ozawa, Shimpei Kawamoto, Daisuke Okuzaki, Keisuke Shimada, Haruhiko Miyata, Kentaro Shimada, Mayo Kodani, Yu Ishikawa-Yamauchi, Daisuke Motooka, Eiji Hara, Masahito Ikawa

Communications biology　Vol. 7　No. 1　p. 16-16　2024年1月4日　研究論文（学術雑誌）

Ccer1 is a spermatid-specific gene required for spermatogenesis and male fertility.

Bianca Sammer, Philomena Schmid, Haruhiko Miyata, Samina Kazi, Anna-Liisa Honkimaa, Petar Petrov, Emmi Kapiainen, Ilkka Miinalainen, Valerio Izzi, Masahito Ikawa, Renata Prunskaite-Hyyryläinen

The International journal of developmental biology　Vol. 68　No. 4　p. 251-262　2024年　研究論文（学術雑誌）

CRISPR/Cas9-mediated genome editing reveals seven testis-enriched transmembrane glycoproteins dispensable for male fertility in mice.

Yo Ogawa, Yonggang Lu, Daiji Kiyozumi, Hsin-Yi Chang, Masahito Ikawa

Andrology　2023年12月12日　研究論文（学術雑誌）

Age-related decline in spermatogenic activity accompanied with endothelial cell senescence in male mice

Manabu Ozawa, Hideto Mori, Tsutomu Endo, Yu Ishikawa-Yamauchi, Daisuke Motooka, Chihiro Emori, Masahiro Ikawa

iScience　Vol. 26　No. 12　p. 108456-108456　2023年12月1日　研究論文（学術雑誌）

Age-associated aberrations of cumulus-oocyte interaction and microfilamentous structure in the zona pellucida decline female fertility

Yu Ishikawa-Yamauchi, Chihiro Emori, Hideto Mori, Tsutomu Endo, Kiyonori Kobayashi, Yuji Watanabe, Hiroshi Sagara, Takeshi Nagata, Daisuke Motooka, Akinori Ninomiya, Manabu Ozawa, Masahito Ikawa

bioRxiv　2023年12月

CCDC183 is essential for cytoplasmic invagination around the flagellum during spermiogenesis and male fertility.

Keisuke Shimada, Masahito Ikawa

Development (Cambridge, England)　Vol. 150　No. 21　2023年11月1日　研究論文（学術雑誌）

Incomplete activation of Alyref and Gabpb1 leads to preimplantation arrest in cloned mouse embryos.

Shunya Ihashi, Mizuto Hamanaka, Masaya Kaji, Ryunosuke Mori, Shuntaro Nishizaki, Miki Mori, Yuma Imasato, Kimiko Inoue, Shogo Matoba, Narumi Ogonuki, Atsushi Takasu, Misaki Nakamura, Kazuya Matsumoto, Masayuki Anzai, Atsuo Ogura, Masahito Ikawa, Kei Miyamoto

Life science alliance　Vol. 6　No. 11　2023年11月　研究論文（学術雑誌）

Adhesion G protein-coupled receptor G2 is dispensable for lumicrine signaling regulating epididymal initial segment differentiation and gene expression†.

Daiji Kiyozumi, Masahito Ikawa

Biology of reproduction　Vol. 109　No. 4　p. 474-481　2023年10月13日　研究論文（学術雑誌）

GREB1 isoform 4 is specifically transcribed by MITF and required for melanoma proliferation.

Koei Shinzawa, Shinji Matsumoto, Ryota Sada, Akikazu Harada, Kaori Saitoh, Keiko Kato, Satsuki Ikeda, Akiyoshi Hirayama, Kazunori Yokoi, Atsushi Tanemura, Keisuke Nimura, Masahito Ikawa, Tomoyoshi Soga, Akira Kikuchi

Oncogene　Vol. 42　No. 42　p. 3142-3156　2023年10月　研究論文（学術雑誌）

A CUG-initiated CATSPERθ functions in the CatSper channel assembly and serves as a checkpoint for flagellar trafficking.

Xiaofang Huang, Haruhiko Miyata, Huafeng Wang, Giulia Mori, Rie Iida-Norita, Masahito Ikawa, Riccardo Percudani, Jean-Ju Chung

Proceedings of the National Academy of Sciences of the United States of America　Vol. 120　No. 39　2023年9月26日　研究論文（学術雑誌）

Oocyte-specific Wee1-like protein kinase 2 is dispensable for fertility in mice.

Kaori Nozawa, Zian Liao, Yuhkoh Satouh, Ting Geng, Masahito Ikawa, Diana Monsivais, Martin M Matzuk

PloS one　Vol. 18　No. 8　2023年8月　研究論文（学術雑誌）

Molecular dissection and testing of PRSS37 function through LC-MS/MS and the generation of a PRSS37 humanized mouse model.

Courtney Sutton, Kaori Nozawa, Katarzyna Kent, Alexander Saltzman, Mei Leng, Sureshbabu Nagarajan, Anna Malovannaya, Masahito Ikawa, Thomas X Garcia, Martin M Matzuk

Scientific reports　Vol. 13　No. 1　p. 11374-11374　2023年7月14日　研究論文（学術雑誌）

Involvement of linker histone variant H1a in the regulation of early preimplantation development in mice.

Satoshi Funaya, Yuan Wang, Masataka G Suzuki, Masahito Ikawa, Fugaku Aoki

The Journal of reproduction and development　Vol. 69　No. 3　p. 178-182　2023年6月6日　研究論文（学術雑誌）

A small secreted protein NICOL regulates lumicrine-mediated sperm maturation and male fertility.

Daiji Kiyozumi, Kentaro Shimada, Michael Chalick, Chihiro Emori, Mayo Kodani, Seiya Oura, Taichi Noda, Tsutomu Endo, Martin M Matzuk, Daniel H Wreschner, Masahito Ikawa

Nature communications　Vol. 14　No. 1　p. 2354-2354　2023年4月24日　研究論文（学術雑誌）

Celastrol suppresses humoral immune responses and autoimmunity by targeting the COMMD3/8 complex.

Taiichiro Shirai, Akiko Nakai, Emiko Ando, Jun Fujimoto, Sarah Leach, Takao Arimori, Daisuke Higo, Floris J van Eerden, Janyerkye Tulyeu, Yu-Chen Liu, Daisuke Okuzaki, Masanori A Murayama, Haruhiko Miyata, Kazuto Nunomura, Bangzhong Lin, Akiyoshi Tani, Atsushi Kumanogoh, Masahito Ikawa, James B Wing, Daron M Standley, Junichi Takagi, Kazuhiro Suzuki

Science immunology　Vol. 8　No. 81　2023年3月31日　研究論文（学術雑誌）

Minimal upstream open reading frame of Per2 mediates phase fitness of the circadian clock to day/night physiological body temperature rhythm.

Takahito Miyake, Yuichi Inoue, Xinyan Shao, Takehito Seta, Yuto Aoki, Khanh Tien Nguyen Pham, Yuichi Shichino, Junko Sasaki, Takehiko Sasaki, Masahito Ikawa, Yoshiaki Yamaguchi, Hitoshi Okamura, Shintaro Iwasaki, Masao Doi

Cell reports　Vol. 42　No. 3　p. 112157-112157　2023年3月28日　研究論文（学術雑誌）

TSKS localizes to nuage in spermatids and regulates cytoplasmic elimination during spermiation.

Keisuke Shimada, Soojin Park, Seiya Oura, Taichi Noda, Akane Morohoshi, Martin M Matzuk, Masahito Ikawa

Proceedings of the National Academy of Sciences of the United States of America　Vol. 120　No. 11　2023年3月14日　研究論文（学術雑誌）

Testis-specific actin-like 7A (ACTL7A) is an indispensable protein for subacrosomal-associated F-actin formation, acrosomal anchoring, and male fertility

P. Ferrer, S. Upadhyay, M. Ikawa, T. M. Clement

Molecular Human Reproduction　Vol. 29　No. 3　2023年3月1日　研究論文（学術雑誌）

Evaluation of the efficacy of creatine chemical exchange saturation transfer imaging in assessing testicular maturity.

Sohei Kuribayashi, Shinichiro Fukuhara, Go Tsujimura, Takahiro Imanaka, Koichi Okada, Norichika Ueda, Kentaro Takezawa, Hiroshi Kiuchi, Shigeyoshi Saito, Yusuke Takahashi, Hidetaka Kioka, Seiya Oura, Keisuke Shimada, Masahito Ikawa, Norio Nonomura

Reproductive medicine and biology　Vol. 22　No. 1　2023年2月23日　研究論文（学術雑誌）

1700029I15Rik orchestrates the biosynthesis of acrosomal membrane proteins required for sperm-egg interaction.

Yonggang Lu, Kentaro Shimada, Shaogeng Tang, Jingjing Zhang, Yo Ogawa, Taichi Noda, Hiroki Shibuya, Masahito Ikawa

Proceedings of the National Academy of Sciences of the United States of America　Vol. 120　No. 8　2023年2月21日　研究論文（学術雑誌）

ADAD2 functions in spermiogenesis and piRNA biogenesis in mice.

Yonggang Lu, Ippei Nagamori, Hisato Kobayashi, Kanako Kojima-Kita, Kenjiro Shirane, Hsin-Yi Chang, Toru Nishimura, Takayuki Koyano, Zhifeng Yu, Julio M Castañeda, Makoto Matsuyama, Satomi Kuramochi-Miyagawa, Martin M Matzuk, Masahito Ikawa

Andrology　Vol. 11　No. 4　p. 698-709　2023年2月14日　研究論文（学術雑誌）

Gene Targeting in Mouse Embryonic Stem Cells via CRISPR/Cas9 Ribonucleoprotein (RNP)-Mediated Genome Editing.

Manabu Ozawa, Chihiro Emori, Masahito Ikawa

Methods in molecular biology (Clifton, N.J.)　Vol. 2637　p. 87-97　2023年2月12日　研究論文（学術雑誌）

Testis-enriched ferlin, FER1L5, is required for Ca2+-activated acrosome reaction and male fertility.

Akane Morohoshi, Haruhiko Miyata, Keizo Tokuhiro, Rie Iida-Norita, Taichi Noda, Yoshitaka Fujihara, Masahito Ikawa

Science advances　Vol. 9　No. 4　2023年1月25日　研究論文（学術雑誌）

Upregulation of Robo4 expression by SMAD signaling suppresses vascular permeability and mortality in endotoxemia and COVID-19 models.

Maaya Morita, Aki Yoneda, Nagisa Tokunoh, Tatsumi Masaki, Keisuke Shirakura, Mayumi Kinoshita, Rina Hashimoto, Naoya Shigesada, Junya Takahashi, Masashi Tachibana, Shota Tanaka, Masanori Obana, Nobumasa Hino, Masahito Ikawa, Kazutake Tsujikawa, Chikako Ono, Yoshiharu Matsuura, Hiroyasu Kidoya, Nobuyuki Takakura, Yoshiaki Kubota, Takefumi Doi, Kazuo Takayama, Yasuo Yoshioka, Yasushi Fujio, Yoshiaki Okada

Proceedings of the National Academy of Sciences of the United States of America　Vol. 120　No. 3　2023年1月17日　研究論文（学術雑誌）

Testis-specific proteins, TSNAXIP1 and 1700010I14RIK, are important for sperm motility and male fertility in mice.

Yuki Kaneda, Haruhiko Miyata, Keisuke Shimada, Seiya Oura, Masahito Ikawa

Andrology　Vol. 11　No. 5　p. 799-807　2023年1月4日　研究論文（学術雑誌）

Development of transgenic mice overexpressing mouse carbonyl reductase 1.

Minako Yokoyama, Toshitsugu Fujita, Yuka Kadonosawa, Yota Tatara, Daisuke Motooka, Masahito Ikawa, Hodaka Fujii, Yoshihito Yokoayama

Molecular biology reports　Vol. 50　No. 1　p. 531-540　2023年1月　研究論文（学術雑誌）

Proximity-dependent biotin labeling in testicular germ cells identified TESMIN-associated proteins.

Seiya Oura, Akinori Ninomiya, Fuminori Sugihara, Martin M Matzuk, Masahito Ikawa

Scientific reports　Vol. 12　No. 1　p. 22198-22198　2022年12月23日　研究論文（学術雑誌）

Efficient simultaneous double DNA knock-in in murine embryonic stem cells by CRISPR/Cas9 ribonucleoprotein-mediated circular plasmid targeting for generating gene-manipulated mice.

Manabu Ozawa, Jumpei Taguchi, Kento Katsuma, Yu Ishikawa-Yamauchi, Mio Kikuchi, Reiko Sakamoto, Yasuhiro Yamada, Masahito Ikawa

Scientific reports　Vol. 12　No. 1　p. 21558-21558　2022年12月13日　研究論文（学術雑誌）

Generation of humanized LDHC knock-in mice as a tool to assess human LDHC-targeting contraceptive drugs.

Rie Iida-Norita, Haruhiko Miyata, Yuki Kaneda, Chihiro Emori, Taichi Noda, Tatsuya Nakagawa, Martin M Matzuk, Masahito Ikawa

Andrology　Vol. 11　No. 5　p. 840-848　2022年12月4日　研究論文（学術雑誌）

CRISPR/Cas9-mediated disruption of lipocalins, Ly6g5b, and Ly6g5c causes male subfertility in mice.

Nobuyuki Sakurai, Yoshitaka Fujihara, Kiyonori Kobayashi, Masahito Ikawa

Andrology　Vol. 12　No. 5　p. 981-990　2022年11月25日　研究論文（学術雑誌）

Eukaryotic fertilization and gamete fusion at a glance.

Yonggang Lu, Masahito Ikawa

Journal of cell science　Vol. 135　No. 22　2022年11月15日　研究論文（学術雑誌）

Testis-specific serine kinase 3 is required for sperm morphogenesis and male fertility.

Kaori Nozawa, Thomas X Garcia, Katarzyna Kent, Mei Leng, Antrix Jain, Anna Malovannaya, Fei Yuan, Zhifeng Yu, Masahito Ikawa, Martin M Matzuk

Andrology　Vol. 11　No. 5　p. 826-839　2022年10月28日　研究論文（学術雑誌）

PDCL2 is essential for sperm acrosome formation and male fertility in mice.

Yoshitaka Fujihara, Kiyonori Kobayashi, Ferheen Abbasi, Tsutomu Endo, Zhifeng Yu, Masahito Ikawa, Martin M Matzuk

Andrology　Vol. 11　No. 5　p. 789-798　2022年10月24日　研究論文（学術雑誌）

Inactivation of SARS-CoV-2 by Commercially Available Disinfectants and Cleaners.

Y U Harada, Hitomi Amo, Takuto Ono, Hiroki Murai, Tadahiro Sasaki, Tatsuo Shioda, Masahito Ikawa, Yoshihiko Hirata

Biocontrol science　Vol. 27　No. 4　p. 223-228　2022年10月4日　研究論文（学術雑誌）

SARS-CoV-2 disrupts respiratory vascular barriers by suppressing Claudin-5 expression.

Rina Hashimoto, Junya Takahashi, Keisuke Shirakura, Risa Funatsu, Kaori Kosugi, Sayaka Deguchi, Masaki Yamamoto, Yugo Tsunoda, Maaya Morita, Kosuke Muraoka, Masato Tanaka, Tomoaki Kanbara, Shota Tanaka, Shigeyuki Tamiya, Nagisa Tokunoh, Atsushi Kawai, Masahito Ikawa, Chikako Ono, Keisuke Tachibana, Masuo Kondoh, Masanori Obana, Yoshiharu Matsuura, Akihiro Ohsumi, Takeshi Noda, Takuya Yamamoto, Yasuo Yoshioka, Yu-Suke Torisawa, Hiroshi Date, Yasushi Fujio, Miki Nagao, Kazuo Takayama, Yoshiaki Okada

Science advances　Vol. 8　No. 38　2022年9月23日　研究論文（学術雑誌）

Retrovirus-derived RTL5 and RTL6 genes are novel constituents of the innate immune system in the eutherian brain

Masahito Irie, Johbu Itoh, Ayumi Matsuzawa, Masahito Ikawa, Hiroshi Kiyonari, Miho Kihara, Toru Suzuki, Yuichi Hiraoka, Fumitoshi Ishino, Tomoko Kaneko-Ishino

Development　Vol. 149　No. 18　2022年9月15日　研究論文（学術雑誌）

MAIA, Fc receptor-like 3, supersedes JUNO as IZUMO1 receptor during human fertilization.

Jana Vondrakova, Michaela Frolikova, Lukas Ded, Jiri Cerny, Pavla Postlerova, Veronika Palenikova, Ondrej Simonik, Zuzana Nahacka, Krystof Basus, Eliska Valaskova, Radek Machan, Allan Pacey, Zuzana Holubcova, Pavel Koubek, Zuzana Ezrova, Soojin Park, Ruiwu Liu, Raghavendran Partha, Nathan Clark, Jiri Neuzil, Masahito Ikawa, Kent Erickson, Kit S Lam, Harry Moore, Katerina Komrskova

Science advances　Vol. 8　No. 36　2022年9月9日　研究論文（学術雑誌）

悪性黒色腫におけるMITF依存的なGREB1アイソフォーム4の発現は、ピリミジン合成を介して細胞増殖を促進する(MITF-dependent GREB1 isoform 4 expression stimulates melanoma proliferation through pyrimidine synthesis)

新澤 康英, 松本 真司, 佐田 遼太, 原田 昭和, 種村 篤, 二村 圭祐, 伊川 正人, 曽我 朋義, 菊池 章

日本癌学会総会記事　Vol. 81回　p. P-2055　2022年9月

悪性黒色腫におけるMITF依存的なGREB1アイソフォーム4の発現は、ピリミジン合成を介して細胞増殖を促進する(MITF-dependent GREB1 isoform 4 expression stimulates melanoma proliferation through pyrimidine synthesis)

新澤 康英, 松本 真司, 佐田 遼太, 原田 昭和, 種村 篤, 二村 圭祐, 伊川 正人, 曽我 朋義, 菊池 章

日本癌学会総会記事　Vol. 81回　p. P-2055　2022年9月

CRISPR/Cas9-Mediated Highly Efficient Gene Targeting in Embryonic Stem Cells for Developing Gene-Manipulated Mouse Models.

Manabu Ozawa, Chihiro Emori, Masahito Ikawa

Journal of visualized experiments : JoVE　No. 186　2022年8月24日　研究論文（学術雑誌）

Tas2R signaling enhances mouse neutrophil migration via a ROCK-dependent pathway.

Daichi Kobayashi, Tomoya Watarai, Madoka Ozawa, Yasuhiro Kanda, Fumihiro Saika, Norikazu Kiguchi, Arata Takeuchi, Masahito Ikawa, Shinsuke Matsuzaki, Tomoya Katakai

Frontiers in immunology　Vol. 13　p. 973880-973880　2022年8月1日　研究論文（学術雑誌）

IRGC1, a testis-enriched immunity related GTPase, is important for fibrous sheath integrity and sperm motility in mice.

Yuki Kaneda, Haruhiko Miyata, Keisuke Shimada, Yuki Oyama, Rie Iida-Norita, Masahito Ikawa

Developmental biology　Vol. 488　p. 104-113　2022年8月1日　研究論文（学術雑誌）

The testis-specific E3 ubiquitin ligase RNF133 is required for fecundity in mice.

Kaori Nozawa, Yoshitaka Fujihara, Darius J Devlin, Ricardo E Deras, Katarzyna Kent, Irina V Larina, Kohei Umezu, Zhifeng Yu, Courtney M Sutton, Qiuji Ye, Laura K Dean, Chihiro Emori, Masahito Ikawa, Thomas X Garcia, Martin M Matzuk

BMC biology　Vol. 20　No. 1　p. 161-161　2022年7月13日　研究論文（学術雑誌）

Correction for Hiramatsu et al., "The Mechanism of Pertussis Cough Revealed by the Mouse-Coughing Model".

Yukihiro Hiramatsu, Koichiro Suzuki, Takashi Nishida, Naoki Onoda, Takashi Satoh, Shizuo Akira, Masahito Ikawa, Hiroko Ikeda, Junzo Kamei, Sandra Derouiche, Makoto Tominaga, Yasuhiko Horiguchi

mBio　Vol. 13　No. 3　2022年6月28日　研究論文（学術雑誌）

Establishment of mouse model of inherited PIGO deficiency and therapeutic potential of AAV-based gene therapy.

Ryoko Kuwayama, Keiichiro Suzuki, Jun Nakamura, Emi Aizawa, Yoshichika Yoshioka, Masahito Ikawa, Shin Nabatame, Ken-Ichi Inoue, Yoshiari Shimmyo, Keiichi Ozono, Taroh Kinoshita, Yoshiko Murakami

Nature communications　Vol. 13　No. 1　p. 3107-3107　2022年6月3日　研究論文（学術雑誌）

T Cell-Intrinsic Vitamin A Metabolism and Its Signaling Are Targets for Memory T Cell-Based Cancer Immunotherapy.

Fumihiro Fujiki, Soyoko Morimoto, Akiko Katsuhara, Akane Okuda, Saeka Ogawa, Eriko Ueda, Maki Miyazaki, Ayako Isotani, Masahito Ikawa, Sumiyuki Nishida, Hiroko Nakajima, Akihiro Tsuboi, Yoshihiro Oka, Jun Nakata, Naoki Hosen, Atsushi Kumanogoh, Yusuke Oji, Haruo Sugiyama

Frontiers in immunology　Vol. 13　p. 935465-935465　2022年6月1日　研究論文（学術雑誌）

Trim41 is required to regulate chromosome axis protein dynamics and meiosis in male mice.

Seiya Oura, Toshiaki Hino, Takashi Satoh, Taichi Noda, Takayuki Koyano, Ayako Isotani, Makoto Matsuyama, Shizuo Akira, Kei-Ichiro Ishiguro, Masahito Ikawa

PLoS genetics　Vol. 18　No. 6　p. e1010241-e1010241　2022年6月1日　研究論文（学術雑誌）

Proteolysis in Reproduction: Lessons From Gene-Modified Organism Studies.

Daiji Kiyozumi, Masahito Ikawa

Frontiers in endocrinology　Vol. 13　p. 876370-876370　2022年5月4日　研究論文（学術雑誌）

TULP2 deletion mice exhibit abnormal outer dense fiber structure and male infertility

Yuki Oyama, Haruhiko Miyata, Keisuke Shimada, Tamara Larasati, Yoshitaka Fujihara, Masahito Ikawa

Reproductive Medicine and Biology　Vol. 21　No. 1　2022年5月1日　研究論文（学術雑誌）

Aspects of the Complement System in New Era of Xenotransplantation

Shuji Miyagawa, Akira Maeda, Chiyoshi Toyama, Shuhei Kogata, Chizu Okamatsu, Riho Yamamoto, Kazunori Masahata, Masafumi Kamiyama, Hiroshi Eguchi, Masahito Watanabe, Hiroshi Nagashima, Masahito Ikawa, Katsuyoshi Matsunami, Hiroomi Okuyama

Frontiers in Immunology　Vol. 13　2022年4月14日　研究論文（学術雑誌）

Sperm membrane proteins DCST1 and DCST2 are required for sperm-egg interaction in mice and fish.

Taichi Noda, Andreas Blaha, Yoshitaka Fujihara, Krista R Gert, Chihiro Emori, Victoria E Deneke, Seiya Oura, Karin Panser, Yonggang Lu, Sara Berent, Mayo Kodani, Luis Enrique Cabrera-Quio, Andrea Pauli, Masahito Ikawa

Communications biology　Vol. 5　No. 1　p. 332-332　2022年4月7日　研究論文（学術雑誌）

Complement regulation in the Triple-KO era, Frontier in Immunol

Miyagawa S, Maeda A, Toyama C, Kogata S, Okamatsu C, Yamamoto R, Masahata K, Kamiyama M, Eguchi H, Watanabe M, Nagashima H, Ikawa M, Matsunami K, Okuyama H

2022年4月

The Mechanism of Pertussis Cough Revealed by the Mouse-Coughing Model

Hiramatsu Y, Suzuki K, Nishida T, Onoda N, Satoh T, Akira S, Ikawa M, Ikeda H, Kamei J, Derouiche S, Tominaga M, Horiguchi Y

mBio　Vol. 13　No. 2　2022年4月　研究論文（学術雑誌）

Multiple tolerance checkpoints restrain affinity maturation of B cells expressing the germline precursor of a lupus patient-derived anti-dsDNA antibody in knock-in mice.

Marwa Ali El Hussien, Chao-Yuan Tsai, Yuhkoh Satouh, Daisuke Motooka, Daisuke Okuzaki, Masahito Ikawa, Hitoshi Kikutani, Shuhei Sakakibara

International immunology　Vol. 34　No. 4　p. 207-223　2022年3月25日　研究論文（学術雑誌）

Loss of mouse Y chromosome gene Zfy1 and Zfy2 leads to spermatogenesis impairment, sperm defects, and infertility.

Yasuhiro Yamauchi, Takafumi Matsumura, Jackson Bakse, Hayden Holmlund, Genevieve Blanchet, Emmaelle Carrot, Masahito Ikawa, Monika A Ward

Biology of reproduction　Vol. 106　No. 6　p. 1312-1326　2022年3月16日　研究論文（学術雑誌）

Loss of the N-acetylgalactosamine side chain of the GPI-anchor impairs bone formation and brain functions and accelerates the prion disease pathology.

Tetsuya Hirata, Atsushi Kobayashi, Tamio Furuse, Ikuko Yamada, Masaru Tamura, Hiroyuki Tomita, Yuko Tokoro, Akinori Ninomiya, Yoshitaka Fujihara, Masahito Ikawa, Yusuke Maeda, Yoshiko Murakami, Yasuhiko Kizuka, Taroh Kinoshita

The Journal of biological chemistry　Vol. 298　No. 3　p. 101720-101720　2022年3月1日　研究論文（学術雑誌）

Kastor and Polluks polypeptides encoded by a single gene locus cooperatively regulate VDAC and spermatogenesis.

Shintaro Mise, Akinobu Matsumoto, Keisuke Shimada, Toshiaki Hosaka, Masatomo Takahashi, Kazuya Ichihara, Hideyuki Shimizu, Chisa Shiraishi, Daisuke Saito, Mikita Suyama, Tomoharu Yasuda, Toru Ide, Yoshihiro Izumi, Takeshi Bamba, Tomomi Kimura-Someya, Mikako Shirouzu, Haruhiko Miyata, Masahito Ikawa, Keiichi I Nakayama

Nature communications　Vol. 13　No. 1　p. 1071-1071　2022年2月28日　研究論文（学術雑誌）

C2cd6-encoded CatSperτ targets sperm calcium channel to Ca2+ signaling domains in the flagellar membrane.

Jae Yeon Hwang, Huafeng Wang, Yonggang Lu, Masahito Ikawa, Jean-Ju Chung

Cell reports　Vol. 38　No. 3　p. 110226-110226　2022年1月18日　研究論文（学術雑誌）

Sperm IZUMO1 Is Required for Binding Preceding Fusion With Oolemma in Mice and Rats.

Takafumi Matsumura, Taichi Noda, Yuhkoh Satouh, Akane Morohoshi, Shunsuke Yuri, Masaki Ogawa, Yonggang Lu, Ayako Isotani, Masahito Ikawa

Frontiers in cell and developmental biology　Vol. 9　p. 810118-810118　2022年1月1日　研究論文（学術雑誌）

FAM71F1 binds to RAB2A and RAB2B and is essential for acrosome formation and male fertility in mice.

Akane Morohoshi, Haruhiko Miyata, Yuki Oyama, Seiya Oura, Taichi Noda, Masahito Ikawa

Development (Cambridge, England)　Vol. 148　No. 21　2021年11月1日　研究論文（学術雑誌）

Uterine Epithelial LIF Receptors Contribute to Implantation Chamber Formation in Blastocyst Attachment

Yamato Fukui, Yasushi Hirota, Tomoko Saito-Fujita, Shizu Aikawa, Takehiro Hiraoka, Tetsuaki Kaku, Tomoyuki Hirata, Shun Akaeda, Mitsunori Matsuo, Ryoko Shimizu-Hirota, Norihiko Takeda, Masahito Ikawa, Yutaka Osuga

Endocrinology　Vol. 162　No. 11　2021年11月1日　研究論文（学術雑誌）

MORC3, a novel MIWI2 association partner, as an epigenetic regulator of piRNA dependent transposon silencing in male germ cells.

Kanako Kojima-Kita, Satomi Kuramochi-Miyagawa, Manabu Nakayama, Haruhiko Miyata, Steven E Jacobsen, Masahito Ikawa, Haruhiko Koseki, Toru Nakano

Scientific reports　Vol. 11　No. 1　p. 20472-20472　2021年10月14日　研究論文（学術雑誌）

NAIL: An evolutionarily conserved lncRNA essential for licensing coordinated activation of p38 and NFκB in colitis

Semih Can Aklncllar, Lele Wu, Qin Feng Ng, Joelle Yi Heng Chua, Bilal Unal, Taichi Noda, Wei Hong Jeff Chor, Masahito Ikawa, Vinay Tergaonkar

Gut　Vol. 70　No. 10　p. 1857-1871　2021年10月1日　研究論文（学術雑誌）

LRRC23 is a conserved component of the radial spoke that is necessary for sperm motility and male fertility in mice.

Xin Zhang, Jiang Sun, Yonggang Lu, Jintao Zhang, Keisuke Shimada, Taichi Noda, Shuqin Zhao, Takayuki Koyano, Makoto Matsuyama, Shushu Zhou, Jiayan Wu, Masahito Ikawa, Mingxi Liu

Journal of cell science　Vol. 134　No. 20　2021年9月29日　研究論文（学術雑誌）

A sublethal ATP11A mutation associated with neurological deterioration causes aberrant phosphatidylcholine flipping in plasma membranes

Katsumori Segawa, Atsuo Kikuchi, Tomoyasu Noji, Yuki Sugiura, Keita Hiraga, Chigure Suzuki, Kazuhiro Haginoya, Yasuko Kobayashi, Mitsuhiro Matsunaga, Yuki Ochiai, Kyoko Yamada, Takuo Nishimura, Shinya Iwasawa, Wataru Shoji, Fuminori Sugihara, Kohei Nishino, Hidetaka Kosako, Masahito Ikawa, Yasuo Uchiyama, Makoto Suematsu, Hiroshi Ishikita, Shigeo Kure, Shigekazu Nagata

Journal of Clinical Investigation　Vol. 131　No. 18　2021年9月15日　研究論文（学術雑誌）

FAM209 associates with DPY19L2 and is required for sperm acrosome biogenesis and fertility in mice

Julio M. Castaneda, Keisuke Shimada, Yuhkoh Satouh, Zhifeng Yu, Masahito Ikawa, Martin M. Matzuk

Journal of Cell Science　Vol. 134　No. 21　2021年9月2日　研究論文（学術雑誌）

The motor domain of testis-enriched kinesin KIF9 is essential for its localization in the mouse flagellum

Haruhiko MIYATA, Yuki OYAMA, Yuki KANEDA, Masahito IKAWA

Experimental Animals　Vol. 71　No. 1　p. 46-52　2021年9月1日　研究論文（学術雑誌）

Rubicon prevents autophagic degradation of GATA4 to promote Sertoli cell function

Tadashi Yamamuro, Shuhei Nakamura, Yu Yamano, Tsutomu Endo, Kyosuke Yanagawa, Ayaka Tokumura, Takafumi Matsumura, Kiyonori Kobayashi, Hideto Mori, Yusuke Enokidani, Gota Yoshida, Hitomi Imoto, Tsuyoshi Kawabata, Maho Hamasaki, Akiko Kuma, Sohei Kuribayashi, Kentaro Takezawa, Yuki Okada, Manabu Ozawa, Shinichiro Fukuhara, Takashi Shinohara, Masahito Ikawa, Tamotsu Yoshimori

PLoS Genetics　Vol. 17　No. 8　2021年8月5日　研究論文（学術雑誌）

Intergenerational effect of short-term spaceflight in mice

Keisuke Yoshida, Shin ichiro Fujita, Ayako Isotani, Takashi Kudo, Satoru Takahashi, Masahito Ikawa, Dai Shiba, Masaki Shirakawa, Masafumi Muratani, Shunsuke Ishii

iScience　Vol. 24　No. 7　2021年7月23日　研究論文（学術雑誌）

CRISPR/Cas9-mediated genome editing reveals 12 testis-enriched genes dispensable for male fertility in mice.

Yuki Oyama, Haruhiko Miyata, Keisuke Shimada, Yoshitaka Fujihara, Keizo Tokuhiro, Thomas X Garcia, Martin M Matzuk, Masahito Ikawa

Asian journal of andrology　2021年7月16日　研究論文（学術雑誌）

Lens–specific conditional knockout of tropomyosin 1 gene in mice causes abnormal fiber differentiation and lens opacity

Teppei Shibata, Masahito Ikawa, Ryo Sakasai, Yasuhito Ishigaki, Etsuko Kiyokawa, Kuniyoshi Iwabuchi, Dhirendra P. Singh, Hiroshi Sasaki, Eri Kubo

Mechanisms of Ageing and Development　Vol. 196　2021年6月1日　研究論文（学術雑誌）

Endometrial receptivity and implantation require uterine BMP signaling through an ACVR2A-SMAD1/SMAD5 axis

Diana Monsivais, Takashi Nagashima, Renata Prunskaite-Hyyryläinen, Kaori Nozawa, Keisuke Shimada, Suni Tang, Clark Hamor, Julio E. Agno, Fengju Chen, Ramya P. Masand, Steven L. Young, Chad J. Creighton, Francesco J. DeMayo, Masahito Ikawa, Se Jin Lee, Martin M. Matzuk

Nature Communications　Vol. 12　No. 1　2021年6月1日　研究論文（学術雑誌）

Precise CAG repeat contraction in a Huntington’s Disease mouse model is enabled by gene editing with SpCas9-NG

Seiya Oura, Taichi Noda, Naoko Morimura, Seiji Hitoshi, Hiroshi Nishimasu, Yoshitaka Nagai, Osamu Nureki, Masahito Ikawa

Communications Biology　Vol. 4　No. 1　2021年6月1日　研究論文（学術雑誌）

KCTD19 and its associated protein ZFP541 are independently essential for meiosis in male mice

Seiya Oura, Takayuki Koyano, Chisato Kodera, Yuki Horisawa-Takada, Makoto Matsuyama, Kei Ichiro Ishiguro, Masahito Ikawa

PLoS Genetics　Vol. 17　No. 5-May　2021年5月7日　研究論文（学術雑誌）

Thiazoline-related innate fear stimuli orchestrate hypothermia and anti-hypoxia via sensory TRPA1 activation

Tomohiko Matsuo, Tomoko Isosaka, Yuichiro Hayashi, Lijun Tang, Akihiro Doi, Aiko Yasuda, Mikio Hayashi, Chia Ying Lee, Liqin Cao, Natsumaro Kutsuna, Sachihiro Matsunaga, Takeshi Matsuda, Ikuko Yao, Mitsuyoshi Setou, Dai Kanagawa, Koichiro Higasa, Masahito Ikawa, Qinghua Liu, Reiko Kobayakawa, Ko Kobayakawa

Nature Communications　Vol. 12　No. 1　2021年4月1日　研究論文（学術雑誌）

A novel tissue specific alternative splicing variant mitigates phenotypes in Ets2 frame-shift mutant models

Yuki Kishimoto, Iori Nishiura, Wataru Hirata, Shunsuke Yuri, Nami Yamamoto, Masahito Ikawa, Ayako Isotani

Scientific Reports　Vol. 11　No. 1　2021年4月1日　研究論文（学術雑誌）

Protocol for isolation of spermatids from mouse testes

Chang Rok Kim, Taichi Noda, Yuki Okada, Masahito Ikawa, Sung Hee Baek

STAR Protocols　Vol. 2　No. 1　p. 100254-100254　2021年3月　研究論文（学術雑誌）

Cooperation-based sperm clusters mediate sperm oviduct entry and fertilization

Yongcun Qu, Qi Chen, Shanshan Guo, Chiyuan Ma, Yonggang Lu, Junchao Shi, Shichao Liu, Tong Zhou, Taichi Noda, Jingjing Qian, Liwen Zhang, Xili Zhu, Xiaohua Lei, Yujing Cao, Wei Li, Wei Li, Nicolas Plachta, Martin M. Matzuk, Masahito Ikawa, Enkui Duan, Ying Zhang, Hongmei Wang

Protein and Cell　Vol. 12　No. 10　p. 810-817　2021年3月1日

Identification and characterization of the antigen recognized by the germ cell mAb TRA98 using a human comprehensive wet protein array

Eriko Fukuda, Hiromitsu Tanaka, Kei Yamaguchi, Mieko Takasaka, Yoshifumi Kawamura, Hidenobu Okuda, Ayako Isotani, Masahito Ikawa, Virginia Smith Shapiro, Junji Tsuchida, Yuki Okada, Akira Tsujimura, Yasushi Miyagawa, Shinichiro Fukuhara, Yoshitaka Kawakami, Morimasa Wada, Yoshitake Nishimune, Naoki Goshima

Genes to Cells　Vol. 26　No. 3　p. 180-189　2021年3月1日　研究論文（学術雑誌）

KCTD19 associates with ZFP541 and HDAC1 and is required for meiotic exit in male mice

Seiya Oura, Takayuki Koyano, Chisato Kodera, Yuki Horisawa-Takada, Makoto Matsuyama, Kei-ichiro Ishiguro, Masahito Ikawa

2021年2月12日

Astrocytic cAMP modulates memory via synaptic plasticity

Zhiwen Zhou, Kazuki Okamoto, Junya Onodera, Toshimitsu Hiragi, Megumi Andoh, Masahito Ikawa, Kenji F. Tanaka, Yuji Ikegaya, Ryuta Koyama

Proceedings of the National Academy of Sciences of the United States of America　Vol. 118　No. 3　2021年1月15日　研究論文（学術雑誌）

Genetic loss of importin α4 causes abnormal sperm morphology and impacts on male fertility in mouse

Yoichi Miyamoto, Mitsuho Sasaki, Haruhiko Miyata, Yoko Monobe, Masahiro Nagai, Mayumi Otani, Penny A.F. Whiley, Akane Morohoshi, Shinya Oki, Junichiro Matsuda, Ken ichi Akagi, Jun Adachi, Masaru Okabe, Masahito Ikawa, Yoshihiro Yoneda, Kate L. Loveland, Masahiro Oka

FASEB Journal　Vol. 34　No. 12　p. 16224-16242　2020年12月1日　研究論文（学術雑誌）

Structural insights into tetraspanin CD9 function

Rie Umeda, Yuhkoh Satouh, Mizuki Takemoto, Yoshiko Nakada-Nakura, Kehong Liu, Takeshi Yokoyama, Mikako Shirouzu, So Iwata, Norimichi Nomura, Ken Sato, Masahito Ikawa, Tomohiro Nishizawa, Osamu Nureki

Nature Communications　Vol. 11　No. 1　p. 1606-1606　2020年12月1日　研究論文（学術雑誌）

IgSF11 regulates osteoclast differentiation through association with the scaffold protein PSD-95

Hyunsoo Kim, Noriko Takegahara, Matthew C. Walsh, Sarah A. Middleton, Jiyeon Yu, Jumpei Shirakawa, Jun Ueda, Yoshitaka Fujihara, Masahito Ikawa, Masaru Ishii, Junhyong Kim, Yongwon Choi

Bone Research　Vol. 8　No. 1　2020年12月1日　研究論文（学術雑誌）

CRISPR/CAS9-mediated amino acid substitution reveals phosphorylation residues of RSPH6A are not essential for male fertility in mice

Haruhiko Miyata, Ferheen Abbasi, Pablo E. Visconti, Masahito Ikawa

Biology of Reproduction　Vol. 103　No. 5　p. 912-914　2020年11月1日　研究論文（学術雑誌）

PGAP6, a GPI-specific phospholipase A2, has narrow substrate specificity against GPI-anchored proteins

Gun Hee Lee, Morihisa Fujita, Hideki Nakanishi, Haruhiko Miyata, Masahito Ikawa, Yusuke Maeda, Yoshiko Murakami, Taroh Kinoshita

Journal of Biological Chemistry　Vol. 295　No. 42　p. 14501-14509　2020年10月16日　研究論文（学術雑誌）

Evidence for lysosomal biogenesis proteome defect and impaired autophagy in preeclampsia

Akitoshi Nakashima, Shi Bin Cheng, Masahito Ikawa, Tamotsu Yoshimori, Warren J. Huber, Ramkumar Menon, Zheping Huang, Jamie Fierce, James F. Padbury, Yoel Sadovsky, Shigeru Saito, Surendra Sharma

Autophagy　Vol. 16　No. 10　p. 1771-1785　2020年10月2日　研究論文（学術雑誌）

Diphtheria toxin-mediated transposon-driven poly (A)-trapping efficiently disrupts transcriptionally silent genes in embryonic stem cells

Jie Bai, Ryohei Kondo, N. Ika Mayasari, Toshiaki Shigeoka, Ayako Isotani, Masahito Ikawa, Goro Sashida, Masashi Kawaichi, Yasumasa Ishida

Genesis　Vol. 58　No. 9　2020年9月1日　研究論文（学術雑誌）

Protocadherin-7 contributes to maintenance of bone homeostasis through regulation of osteoclast multinucleation

Hyunsoo Kim, Noriko Takegahara, Matthew C. Walsh, Jun Ueda, Yoshitaka Fujihara, Masahito Ikawa, Yongwon Choi

BMB Reports　Vol. 53　No. 9　p. 472-477　2020年9月1日　研究論文（学術雑誌）

Large-scale discovery of male reproductive tract-specific genes through analysis of RNA-seq datasets

Matthew J. Robertson, Katarzyna Kent, Nathan Tharp, Kaori Nozawa, Laura Dean, Michelle Mathew, Sandra L. Grimm, Zhifeng Yu, Christine Légaré, Yoshitaka Fujihara, Masahito Ikawa, Robert Sullivan, Cristian Coarfa, Martin M. Matzuk, Thomas X. Garcia

BMC Biology　Vol. 18　No. 1　2020年8月19日　研究論文（学術雑誌）

Knockout of serine-rich single-pass membrane protein 1 (Ssmem1) causes globozoospermia and sterility in male mice

Kaori Nozawa, Qian Zhang, Haruhiko Miyata, Darius J. Devlin, Zhifeng Yu, Seiya Oura, Takayuki Koyano, Makoto Matsuyama, Masahito Ikawa, Martin M. Matzuk

Biology of Reproduction　Vol. 103　No. 2　p. 244-253　2020年8月1日　研究論文（国際会議プロシーディングス）

CIB4 is essential for the haploid phase of spermatogenesis in mice

Zoulan Xu, Haruhiko Miyata, Yuki Kaneda, Julio M. Castaneda, Yonggang Lu, Akane Morohoshi, Zhifeng Yu, Martin M. Matzuk, Masahito Ikawa

Biology of Reproduction　Vol. 103　No. 2　p. 235-243　2020年8月1日　研究論文（国際会議プロシーディングス）

Tmprss12 is required for sperm motility and uterotubal junction migration in mice

Tamara Larasati, Taichi Noda, Yoshitaka Fujihara, Keisuke Shimada, Tomohiro Tobita, Zhifeng Yu, Martin M. Matzuk, Masahito Ikawa

Biology of Reproduction　Vol. 103　No. 2　p. 254-263　2020年8月1日　研究論文（国際会議プロシーディングス）

CRISPR/Cas9-mediated genome-edited mice reveal 10 testis-enriched genes are dispensable for male fecundity

Soojin Park, Keisuke Shimada, Yoshitaka Fujihara, Zoulan Xu, Kentaro Shimada, Tamara Larasati, Putri Pratiwi, Ryan M. Matzuk, Darius J. Devlin, Zhifeng Yu, Thomas X. Garcia, Martin M. Matzuk, Masahito Ikawa

Biology of Reproduction　Vol. 103　No. 2　p. 195-204　2020年8月1日　研究論文（国際会議プロシーディングス）

Knockout of family with sequence similarity 170 member A (Fam170a) causes male subfertility, while Fam170b is dispensable in mice

Darius J. Devlin, Kaori Nozawa, Masahito Ikawa, Martin M. Matzuk

Biology of Reproduction　Vol. 103　No. 2　p. 205-222　2020年8月1日　研究論文（国際会議プロシーディングス）

CRISPR/Cas9-based genome editing in mice uncovers 13 testis- or epididymis-enriched genes individually dispensable for male reproduction

Jiang Sun, Yonggang Lu, Kaori Nozawa, Zoulan Xu, Akane Morohoshi, Julio M. Castaneda, Taichi Noda, Haruhiko Miyata, Ferheen Abbasi, Hossam H. Shawki, Satoru Takahashi, Darius J. Devlin, Zhifeng Yu, Ryan M. Matzuk, Thomas X. Garcia, Martin M. Matzuk, Masahito Ikawa

Biology of Reproduction　Vol. 103　No. 2　p. 183-194　2020年8月1日　研究論文（国際会議プロシーディングス）

Prss55 but not Prss51 is required for male fertility in mice

Kiyonori Kobayashi, Tsutomu Endo, Takafumi Matsumura, Yonggang Lu, Zhifeng Yu, Martin M. Matzuk, Masahito Ikawa

Biology of Reproduction　Vol. 103　No. 2　p. 223-234　2020年8月1日　研究論文（国際会議プロシーディングス）

PHF7 Modulates BRDT Stability and Histone-to-Protamine Exchange during Spermiogenesis

Chang Rok Kim, Taichi Noda, Hyunkyung Kim, Gibeom Kim, Seongwan Park, Yongwoo Na, Seiya Oura, Keisuke Shimada, Injin Bang, Jun Yeong Ahn, Yong Ryoul Kim, Se Kyu Oh, Hee Jung Choi, Jong Seo Kim, Inkyung Jung, Ho Lee, Yuki Okada, Masahito Ikawa, Sung Hee Baek

Cell Reports　Vol. 32　No. 4　2020年7月28日　研究論文（学術雑誌）

Reduction in BDNF from inefficient precursor conversion influences nest building and promotes depressive-like behavior in mice

Masami Kojima, Hikari Otabi, Haruko Kumanogoh, Atsushi Toyoda, Masahito Ikawa, Masaru Okabe, Toshiyuki Mizui

International Journal of Molecular Sciences　Vol. 21　No. 11　2020年6月1日　研究論文（学術雑誌）

Identification of transmembrane protein 168 mutation in familial Brugada syndrome

Akio Shimizu, Dimitar P. Zankov, Akira Sato, Masahiro Komeno, Futoshi Toyoda, Satoru Yamazaki, Toshinori Makita, Taichi Noda, Masahito Ikawa, Yoshihiro Asano, Yohei Miyashita, Seiji Takashima, Hiroshi Morita, Taisuke Ishikawa, Naomasa Makita, Masahito Hitosugi, Hiroshi Matsuura, Seiko Ohno, Minoru Horie, Hisakazu Ogita

FASEB Journal　Vol. 34　No. 5　p. 6399-6417　2020年5月1日　研究論文（学術雑誌）

Tesmin, Metallothionein-Like 5, is Required for Spermatogenesis in Mice

Asami Oji, Ayako Isotani, Yoshitaka Fujihara, Julio M. Castaneda, Seiya Oura, Masahito Ikawa

Biology of Reproduction　Vol. 102　No. 4　p. 975-983　2020年4月　研究論文（学術雑誌）

Testis-enriched kinesin KIF9 is important for progressive motility in mouse spermatozoa

Haruhiko Miyata, Keisuke Shimada, Akane Morohoshi, Seiya Oura, Takafumi Matsumura, Zoulan Xu, Yuki Oyama, Masahito Ikawa

FASEB Journal　Vol. 34　No. 4　p. 5389-5400　2020年4月　研究論文（学術雑誌）

Mouse t-complex protein 11 is important for progressive motility in sperm

Julio M. Castaneda, Haruhiko Miyata, Denise R. Archambeault, Yuhkoh Satouh, Zhifeng Yu, Masahito Ikawa, Martin M. Matzuk

Biology of Reproduction　Vol. 102　No. 4　p. 852-862　2020年4月　研究論文（学術雑誌）

CRISPR/Cas9-Mediated Genome Editing Reveals Oosp Family Genes are Dispensable for Female Fertility in Mice

Ferheen Abbasi, Mayo Kodani, Chihiro Emori, Daiji Kiyozumi, Masashi Mori, Yoshitaka Fujihara, Masahito Ikawa

Cells　Vol. 9　No. 4　2020年3月28日　研究論文（学術雑誌）

The testis-specific serine proteases PRSS44, PRSS46, and PRSS54 are dispensable for male mouse fertility

Richard J. Holcomb, Seiya Oura, Kaori Nozawa, Katarzyna Kent, Zhifeng Yu, Matthew J. Robertson, Cristian Coarfa, Martin M. Matzuk, Masahito Ikawa, Thomas X. Garcia

Biology of Reproduction　Vol. 102　No. 1　p. 84-91　2020年2月12日　研究論文（学術雑誌）

PITHD1 is a proteasome-interacting protein essential for male fertilization

Hiroyuki Kondo, X. Takafumi Matsumura, Mari Kaneko, Kenichi Inoue, Hidetaka Kosako, Masahito Ikawa, Yousuke Takahama, Izumi Ohigashi

Journal of Biological Chemistry　Vol. 295　No. 6　p. 1658-1672　2020年　研究論文（学術雑誌）

Dgkg knock-out mice show impairments in cerebellar motor coordination, Ltd, and the dendritic development of purkinje cells through the activation of pkcg

Ryosuke Tsumagari, Sho Kakizawa, Sakiko Kikunaga, Yoshitaka Fujihara, Shuji Ueda, Minoru Yamanoue, Naoaki Saito, Masahito Ikawa, Yasuhito Shirai

eNeuro　Vol. 7　No. 2　p. ENEURO.0319-19.2020　2020年　研究論文（学術雑誌）

Analysis of the sperm flagellar axoneme using gene-modified mice

Haruhiko Miyata, Akane Morohoshi, Masahito Ikawa

Experimental Animals　Vol. 69　No. 4　p. 374-381　2020年

Genetic mutation of Frem3 does not cause fraser syndrome in mice

Daiji Kiyozumi, Masashi Mori, Mayo Kodani, Masahito Ikawa

Experimental Animals　Vol. 69　No. 1　p. 104-109　2020年　研究論文（学術雑誌）

Polarized PtdIns(4,5)P<inf>2</inf> distribution mediated by a voltage-sensing phosphatase (VSP) regulates sperm motility

Takafumi Kawai, Haruhiko Miyata, Hiroki Nakanishi, Souhei Sakata, Shin Morioka, Junko Sasaki, Masahiko Watanabe, Kenji Sakimura, Toyoshi Fujimoto, Takehiko Sasaki, Masahito Ikawa, Yasushi Okamura

Proceedings of the National Academy of Sciences of the United States of America　Vol. 116　No. 51　p. 26020-26028　2019年12月17日　研究論文（学術雑誌）

Calaxin is required for cilia-driven determination of vertebrate laterality

Keita Sasaki, Kogiku Shiba, Akihiro Nakamura, Natsuko Kawano, Yuhkoh Satouh, Hiroshi Yamaguchi, Motohiro Morikawa, Daisuke Shibata, Ryuji Yanase, Kei Jokura, Mami Nomura, Mami Miyado, Shuji Takada, Hironori Ueno, Shigenori Nonaka, Tadashi Baba, Masahito Ikawa, Masahide Kikkawa, Kenji Miyado, Kazuo Inaba

Communications Biology　Vol. 2　No. 1　2019年12月　研究論文（学術雑誌）

Rap1 regulates hematopoietic stem cell survival and affects oncogenesis and response to chemotherapy

Ekta Khattar, Kyaw Ze Ya Maung, Chen Li Chew, Arkasubhra Ghosh, Michelle Meng Huang Mok, Pei Lee, Jun Zhang, Wei Hong Jeff Chor, Gökhan Cildir, Chelsia Qiuxia Wang, Nur Khairiah Mohd-Ismail, Desmond Wai Loon Chin, Soo Chin Lee, Henry Yang, Yong Jae Shin, Do Hyun Nam, Liming Chen, Alan Prem Kumar, Lih Wen Deng, Masahito Ikawa, Jayantha Gunaratne, Motomi Osato, Vinay Tergaonkar

Nature Communications　Vol. 10　No. 1　p. 5349-5349　2019年12月1日　研究論文（学術雑誌）

Male mice, caged in the International Space Station for 35 days, sire healthy offspring

Takafumi Matsumura, Taichi Noda, Masafumi Muratani, Risa Okada, Mutsumi Yamane, Ayako Isotani, Takashi Kudo, Satoru Takahashi, Masahito Ikawa

Scientific Reports　Vol. 9　No. 1　2019年12月1日　研究論文（学術雑誌）

Cutting edge: Role of MASP-3 in the physiological activation of factor D of the alternative complement pathway

Manabu Hayashi, Takeshi Machida, Yumi Ishida, Yusuke Ogata, Tomoko Omori, Mika Takasumi, Yuichi Endo, Toshiyuki Suzuki, Masayuki Sekimata, Yoshimi Homma, Masahito Ikawa, Hiromasa Ohira, Teizo Fujita, Hideharu Sekine

Journal of Immunology　Vol. 203　No. 6　p. 1411-1416　2019年9月15日　研究論文（学術雑誌）

CRISPR/Cas9-mediated genome editing reveals 30 testis-enriched genes dispensable for male fertility in mice†.

Lu Y, Oura S, Matsumura T, Oji A, Sakurai N, Fujihara Y, Shimada K, Miyata H, Tobita T, Noda T, Castaneda JM, Kiyozumi D, Zhang Q, Larasati T, Young SAM, Kodani M, Huddleston CA, Robertson MJ, Coarfa C, Isotani A, Aitken RJ, Okabe M, Matzuk MM, Garcia TX, Ikawa M

Biology of reproduction　Vol. 101　No. 2　p. 501-511　2019年8月1日　研究論文（学術雑誌）

Erratum: Publisher Correction: Calaxin is required for cilia-driven determination of vertebrate laterality (Communications biology (2019) 2 (226))

Keita Sasaki, Kogiku Shiba, Akihiro Nakamura, Natsuko Kawano, Yuhkoh Satouh, Hiroshi Yamaguchi, Motohiro Morikawa, Daisuke Shibata, Ryuji Yanase, Kei Jokura, Mami Nomura, Mami Miyado, Shuji Takada, Hironori Ueno, Shigenori Nonaka, Tadashi Baba, Masahito Ikawa, Masahide Kikkawa, Kenji Miyado, Kazuo Inaba

Communications biology　Vol. 2　No. 1　2019年7月4日　研究論文（学術雑誌）

GPAT2 is required for piRNA biogenesis, transposon silencing, and maintenance of spermatogonia in mice†.

Shiromoto Y, Kuramochi-Miyagawa S, Nagamori I, Chuma S, Arakawa T, Nishimura T, Hasuwa H, Tachibana T, Ikawa M, Nakano T

Biology of reproduction　Vol. 101　No. 1　p. 248-256　2019年7月1日　研究論文（学術雑誌）

Physiological function of seminal vesicle secretions on male fecundity

Taichi Noda, Masahito Ikawa

Reproductive Medicine and Biology　Vol. 18　No. 3　p. 241-246　2019年7月

Calaxin is required for cilia-driven determination of vertebrate laterality

Keita Sasaki, Kogiku Shiba, Akihiro Nakamura, Natsuko Kawano, Yuhkoh Satouh, Hiroshi Yamaguchi, Motohiro Morikawa, Daisuke Shibata, Ryuji Yanase, Kei Jokura, Mami Nomura, Mami Miyado, Shuji Takada, Hironori Ueno, Shigenori Nonaka, Tadashi Baba, Masahito Ikawa, Masahide Kikkawa, Kenji Miyado, Kazuo Inaba

Communications biology　Vol. 2　No. 1　2019年6月20日　研究論文（学術雑誌）

Mice with Calr mutations homologous to human CALR mutations only exhibit mild thrombocytosis

Kotaro Shide, Takuro Kameda, Ayako Kamiunten, Asami Oji, Yoshinori Ozono, Masaaki Sekine, Arata Honda, Akira Kitanaka, Keiichi Akizuki, Yuki Tahira, Kenichi Nakamura, Tomonori Hidaka, Yoko Kubuki, Hiroo Abe, Tadashi Miike, Hisayoshi Iwakiri, Yoshihiro Tahara, Mitsue Sueta, Satoru Hasuike, Shojiro Yamamoto, Kenji Nagata, Masahito Ikawa, Kazuya Shimoda

Blood Cancer Journal　Vol. 9　No. 4　2019年4月　研究論文（学術雑誌）

USP15 participates in hepatitis C virus propagation through regulation of viral RNA translation and lipid droplet formation

Shinji Kusakabe, Tatsuya Suzuki, Yukari Sugiyama, Saori Haga, Kanako Horike, Makoto Tokunaga, Junki Hirano, He Zhang, David Virya Chen, Hanako Ishiga, Yasumasa Komoda, Chikako Ono, Takasuke Fukuhara, Masahiro Yamamoto, Masahito Ikawa, Takashi Satoh, Shizuo Akira, Tomohisa Tanaka, Kohji Moriishi, Moto Fukai, Akinobu Taketomi, Sachiyo Yoshio, Tatsuya Kanto, Tetsuro Suzuki, Toru Okamoto, Yoshiharu Matsuura

Journal of Virology　Vol. 93　No. 6　2019年3月1日　研究論文（学術雑誌）

CRISPR-Cas9システムを用いたTpm2ノックアウトマウスによる白内障研究

柴田 哲平, 石垣 靖人, 柴田 伸亮, 清川 悦子, 伊川 正人, Dhirendra P Singh, 佐々木 洋, 久保 江理

日本白内障学会誌　Vol. 31　No. 1　p. 30-32　2019年

Developmental analyses of mouse embryos and adults using a non-overlapping tracing system for all three germ layers

Takashi Serizawa, Ayako Isotani, Takafumi Matsumura, Katsuyuki Nakanishi, Shigenori Nonaka, Shinsuke Shibata, Masahito Ikawa, Hideyuki Okano

Development (Cambridge)　Vol. 146　No. 21　2019年　研究論文（学術雑誌）

Nine genes abundantly expressed in the epididymis are not essential for male fecundity in mice

T. Noda, N. Sakurai, K. Nozawa, S. Kobayashi, D. J. Devlin, M. M. Matzuk, M. Ikawa

Andrology　Vol. 7　No. 5　p. 644-653　2019年　研究論文（学術雑誌）

CKAP4, a DKK1 receptor, is a biomarker in exosomes derived from pancreatic cancer and a molecular target for therapy

Hirokazu Kimura, Hideki Yamamoto, Takeshi Harada, Katsumi Fumoto, Yoshihito Osugi, Ryota Sada, Natsumi Maehara, Hayato Hikita, Soichiro Mori, Hidetoshi Eguchi, Masahito Ikawa, Tetsuo Takehara, Akira Kikuchi

Clinical Cancer Research　Vol. 25　No. 6　p. 1936-1947　2019年　研究論文（学術雑誌）

PTBP1 contributes to spermatogenesis through regulation of proliferation in spermatogonia

Manami Senoo, Takashi Takijiri, Nobuaki Yoshida, Manabu Ozawa, Masahito Ikawa

Journal of Reproduction and Development　Vol. 65　No. 1　p. 37-46　2019年　研究論文（学術雑誌）

Lvrn expression is not critical for mouse placentation

Tomohiro Tobita, Daiji Kiyozumi, Masanaga Muto, Taichi Noda, Masahito Ikawa

Journal of Reproduction and Development　Vol. 65　No. 3　p. 239-244　2019年　研究論文（学術雑誌）

Ventricular–subventricular zone fractones are speckled basement membranes that function as a neural stem cell niche

Yuya Sato, Daiji Kiyozumi, Sugiko Futaki, Itsuko Nakano, Chisei Shimono, Naoko Kaneko, Masahito Ikawa, Masaru Okabe, Kazunobu Sawamoto, Kiyotoshi Sekiguchi

Molecular Biology of the Cell　Vol. 30　No. 1　p. 56-68　2019年1月1日　研究論文（学術雑誌）

An azoospermic factor gene, Ddx3y and its paralog, Ddx3x are dispensable in germ cells for male fertility

Takafumi Matsumura, Tsutomu Endo, Ayako Isotani, Masaki Ogawa, Masahito Ikawa

Journal of Reproduction and Development　Vol. 65　No. 2　p. 121-128　2019年　研究論文（学術雑誌）

Glycerol kinase 2 is essential for proper arrangement of crescent-like mitochondria to form the mitochondrial sheath during mouse spermatogenesis

Keisuke Shimada, Hirotaka Kato, Haruhiko Miyata, Masahito Ikawa

Journal of Reproduction and Development　Vol. 65　No. 2　p. 155-162　2019年　研究論文（学術雑誌）

Seminal vesicle secretory protein 7, PATE4, is not required for sperm function but for copulatory plug formation to ensure fecundity

Taichi Noda, Yoshitaka Fujihara, Takafumi Matsumura, Seiya Oura, Sumire Kobayashi, Masahito Ikawa

Biology of Reproduction　Vol. 100　No. 4　p. 1035-1045　2019年　研究論文（学術雑誌）

Chimeric analysis with newly established EGFP/DsRed2-tagged ES cells identify HYDIN as essential for spermiogenesis in mice

Seiya Oura, Haruhiko Miyata, Taichi Noda, Keisuke Shimada, Takafumi Matsumura, Akane Morohoshi, Ayako Isotani, Masahito Ikawa

Experimental Animals　Vol. 68　No. 1　p. 25-34　2019年　研究論文（学術雑誌）

Calaxin is required for cilia-driven determination of vertebrate laterality.

Keita Sasaki, Kogiku Shiba, Akihiro Nakamura, Natsuko Kawano, Yuhkoh Satouh, Hiroshi Yamaguchi, Motohiro Morikawa, Daisuke Shibata, Ryuji Yanase, Kei Jokura, Mami Nomura, Mami Miyado, Shuji Takada, Hironori Ueno, Shigenori Nonaka, Tadashi Baba, Masahito Ikawa, Masahide Kikkawa, Kenji Miyado, Kazuo Inaba

Communications biology　Vol. 2　p. 226-226　2019年　研究論文（学術雑誌）

Sperm-borne phospholipase C zeta-1 ensures monospermic fertilization in mice

Kaori Nozawa, Yuhkoh Satouh, Takao Fujimoto, Asami Oji, Masahito Ikawa

Scientific Reports　Vol. 8　No. 1　2018年12月1日　研究論文（学術雑誌）

Impaired male fertility and abnormal epididymal epithelium differentiation in mice lacking CRISP1 and CRISP4

Guillermo Carvajal, Nicolás Gastón Brukman, Mariana Weigel Muñoz, María A. Battistone, Vanesa A. Guazzone, Masahito Ikawa, Miyata Haruhiko, Livia Lustig, Sylvie Breton, Patricia S. Cuasnicu

Scientific Reports　Vol. 8　No. 1　2018年12月1日　研究論文（学術雑誌）

Trophoblast-Specific Conditional Atg7 Knockout Mice Develop Gestational Hypertension

Aiko Aoki, Akitoshi Nakashima, Tae Kusabiraki, Yosuke Ono, Osamu Yoshino, Masanaga Muto, Keiichi Kumasawa, Tamotsu Yoshimori, Masahito Ikawa, Shigeru Saito

American Journal of Pathology　Vol. 188　No. 11　p. 2474-2486　2018年11月　研究論文（学術雑誌）

RSPH6A is required for sperm flagellum formation and male fertility in mice

Ferheen Abbasi, Haruhiko Miyata, Keisuke Shimada, Akane Morohoshi, Kaori Nozawa, Takafumi Matsumura, Zoulan Xu, Putri Pratiwi, Masahito Ikawa

Journal of Cell Science　Vol. 131　No. 19　2018年10月1日　研究論文（学術雑誌）

Co-expression of sperm membrane proteins CMTM2A and CMTM2B is essential for ADAM3 localization and male fertility in mice

Yoshitaka Fujihara, Asami Oji, Kanako Kojima-Kita, Tamara Larasati, Masahito Ikawa

Journal of Cell Science　Vol. 131　No. 19　2018年10月1日　研究論文（学術雑誌）

New Insights into the Molecular Events of Mammalian Fertilization

Yuhkoh Satouh, Masahito Ikawa

Trends in Biochemical Sciences　Vol. 43　No. 10　p. 818-828　2018年10月

Infection with flaviviruses requires BCLX<inf>L</inf> for cell survival

Tatsuya Suzuki, Toru Okamoto, Hiroshi Katoh, Yukari Sugiyama, Shinji Kusakabe, Makoto Tokunaga, Junki Hirano, Yuka Miyata, Takasuke Fukuhara, Masahito Ikawa, Takashi Satoh, Sachiyo Yoshio, Ryosuke Suzuki, Masayuki Saijo, David C.S. Huang, Tatsuya Kanto, Shizuo Akira, Yoshiharu Matsuura

PLoS Pathogens　Vol. 14　No. 9　2018年9月　研究論文（学術雑誌）

mDia1/3 generate cortical F-actin meshwork in Sertoli cells that is continuous with contractile F-actin bundles and indispensable for spermatogenesis and male fertility

Satoko Sakamoto, Dean Thumkeo, Hiroshi Ohta, Zhen Zhang, Shuangru Huang, Pakorn Kanchanawong, Takayoshi Fuu, Sadanori Watanabe, Kentaro Shimada, Yoshitaka Fujihara, Shosei Yoshida, Masahito Ikawa, Naoki Watanabe, Mitinori Saitou, Shuh Narumiya

PLoS Biology　Vol. 16　No. 9　2018年9月　研究論文（学術雑誌）

Correction: Two Ck1δ transcripts regulated by m6A meth-ylation code for two antagonistic kinases in the control of the circadian clock (Proceedings of the National Academy of Sciences of the United States of America (2018) 115 (5980-5985) DOI: 10.1073/pnas.1721371115)

Jean Michel Fustin, Rika Kojima, Kakeru Itoh, Hsin Yi Chang, Shiqi Ye, Bowen Zhuang, Asami Oji, Shingo Gibo, Rajesh Narasimamurthy, David Virshup, Gen Kurosawa, Masao Doi, Ichiro Manabe, Yasushi Ishihama, Masahito Ikawa, Hitoshi Okamura

Proceedings of the National Academy of Sciences of the United States of America　Vol. 115　No. 27　2018年7月3日　研究論文（学術雑誌）

Two Ck1δ transcripts regulated by m6A methylation code for two antagonistic kinases in the control of the circadian clock.

Fustin JM, Kojima R, Itoh K, Chang HY, Ye S, Zhuang B, Oji A, Gibo S, Narasimamurthy R, Virshup D, Kurosawa G, Doi M, Manabe I, Ishihama Y, Ikawa M, Okamura H

Proceedings of the National Academy of Sciences of the United States of America　Vol. 115　No. 23　p. 5980-5985　2018年6月5日　研究論文（学術雑誌）

Intravesicular acidification regulates lipopolysaccharide inflammation and tolerance through TLR4 trafficking

Motoya Murase, Takumi Kawasaki, Rika Hakozaki, Takuya Sueyoshi, Dyaningtyas Dewi Pamungkas Putri, Yuichi Kitai, Shintaro Sato, Masahito Ikawa, Taro Kawai

Journal of Immunology　Vol. 200　No. 8　p. 2798-2808　2018年4月　研究論文（学術雑誌）

Transgenic mouse lines expressing the 3xFLAG-dCas9 protein for enChIP analysis

Toshitsugu Fujita, Fusako Kitaura, Asami Oji, Naoki Tanigawa, Miyuki Yuno, Masahito Ikawa, Ichiro Taniuchi, Hodaka Fujii

Genes to Cells　Vol. 23　No. 4　p. 318-325　2018年4月　研究論文（学術雑誌）

Tropomyosin 2 heterozygous knockout in mice using CRISPR-Cas9 system displays the inhibition of injury-induced epithelial-mesenchymal transition, and lens opacity

Teppei Shibata, Shinsuke Shibata, Yasuhito Ishigaki, Etsuko Kiyokawa, Masahito Ikawa, Dhirendra P. Singh, Hiroshi Sasaki, Eri Kubo

Mechanisms of Ageing and Development　Vol. 171　p. 24-30　2018年4月　研究論文（学術雑誌）

MARCKSL1 Regulates Spine Formation in the Amygdala and Controls the Hypothalamic-Pituitary-Adrenal Axis and Anxiety-Like Behaviors

Takashi Tanaka, Shoko Shimizu, Masaki Ueno, Yoshitaka Fujihara, Masahito Ikawa, Shingo Miyata

EBioMedicine　Vol. 30　p. 62-73　2018年4月　研究論文（学術雑誌）

妊娠高血圧腎症に対するプロトンポンプ阻害薬の効果

恩田 健二, Tong Stephen, 武藤 真長, Laura Parry, Dilworth Mark, 伊川 正人, 平野 俊彦, Hannan Natalie

日本薬学会年会要旨集　Vol. 138年会　No. 4　p. 62-62　2018年3月

Factors controlling sperm migration through the oviduct revealed by gene-modified mouse models

Yoshitaka Fujihara, Haruhiko Miyata, Masahito Ikawa

Experimental Animals　Vol. 67　No. 2　p. 91-104　2018年

Revolutionizing male fertility factor research in mice by using the genome editing tool CRISPR/Cas9

Ferheen Abbasi, Haruhiko Miyata, Masahito Ikawa

Reproductive Medicine and Biology　Vol. 17　No. 1　p. 3-10　2018年1月

Laminin γ1 C-terminal Glu to Gln mutation induces early postimplantation lethality.

Kiyozumi D, Taniguchi Y, Nakano I, Toga J, Yagi E, Hasuwa H, Ikawa M, Sekiguchi K

Life science alliance　Vol. 1　No. 5　2018年　研究論文（学術雑誌）

Sperm defects

Julio M. Castañeda, Haruhiko Miyata, Masahito Ikawa, Martin M. Matzuk

Encyclopedia of Reproduction　No. 4　p. 276-281　2018年1月1日　論文集(書籍)内論文

Engineered CRISPR-Cas9 nuclease with expanded targeting space

Hiroshi Nishimasu, Xi Shi, Soh Ishiguro, Linyi Gao, Seiichi Hirano, Sanae Okazaki, Taichi Noda, Omar O. Abudayyeh, Jonathan S. Gootenberg, Hideto Mori, Seiya Oura, Benjamin Holmes, Mamoru Tanaka, Motoaki Seki, Hisato Hirano, Hiroyuki Aburatani, Ryuichiro Ishitani, Masahito Ikawa, Nozomu Yachie, Feng Zhang, Osamu Nureki

Science　Vol. 361　No. 6408　p. 1259-1262　2018年　研究論文（学術雑誌）

Vestigial-like 2 contributes to normal muscle fiber type distribution in mice

Masahiko Honda, Kyoko Hidaka, So Ichiro Fukada, Ryo Sugawa, Manabu Shirai, Masahito Ikawa, Takayuki Morisaki

Scientific Reports　Vol. 7　No. 1　2017年12月1日　研究論文（学術雑誌）

Modification of single-nucleotide polymorphism in a fully humanized CYP3A mouse by genome editing technology

Satoshi Abe, Kaoru Kobayashi, Asami Oji, Tetsushi Sakuma, Kanako Kazuki, Shoko Takehara, Kazuomi Nakamura, Azusa Okada, Yasuko Tsukazaki, Naoto Senda, Kazuhisa Honma, Takashi Yamamoto, Masahito Ikawa, Kan Chiba, Mitsuo Oshimura, Yasuhiro Kazuki

Scientific Reports　Vol. 7　No. 1　2017年12月1日　研究論文（学術雑誌）

Suppression of HBV replication by the expression of nickase-and nuclease dead-Cas9

Takeshi Kurihara, Takasuke Fukuhara, Chikako Ono, Satomi Yamamoto, Kentaro Uemura, Toru Okamoto, Masaya Sugiyama, Daisuke Motooka, Shota Nakamura, Masato Ikawa, Masashi Mizokami, Yoshihiko Maehara, Yoshiharu Matsuura

Scientific Reports　Vol. 7　No. 1　2017年12月1日　研究論文（学術雑誌）

Placenta-specific gene manipulation using lentiviral vector and its application

Tomohiro Tobita, Daiji Kiyozumi, Masahito Ikawa

Placenta　Vol. 59　No. Suppl 1　p. S37-S43　2017年11月　研究論文（学術雑誌）

Human globozoospermia-related gene spata16 is required for sperm formation revealed by CRISPR/Cas9-mediated mouse models

Yoshitaka Fujihara, Asami Oji, Tamara Larasati, Kanako Kojima-Kita, Masahito Ikawa

International Journal of Molecular Sciences　Vol. 18　No. 10　2017年10月21日　研究論文（学術雑誌）

New insights into the role of Jmjd3 and Utx in axial skeletal formation in mice

Chie Naruse, Shinwa Shibata, Masaru Tamura, Takayuki Kawaguchi, Kanae Abe, Kazushi Sugihara, Tomoaki Kato, Takumi Nishiuchi, Shigeharu Wakana, Masahito Ikawa, Masahide Asano

FASEB Journal　Vol. 31　No. 6　p. 2252-2266　2017年6月　研究論文（学術雑誌）

BATF2 inhibits immunopathological Th17 responses by suppressing Il23a expression during Trypanosoma cruzi infection

Shoko Kitada, Hisako Kayama, Daisuke Okuzaki, Ritsuko Koga, Masao Kobayashi, Yasunobu Arima, Atsushi Kumanogoh, Masaaki Murakami, Masahito Ikawa, Kiyoshi Takeda

Journal of Experimental Medicine　Vol. 214　No. 5　p. 1313-1331　2017年5月1日　研究論文（学術雑誌）

The mechanics clarifying counterclockwise rotation in most IVF eggs in mice

Kenta Ishimoto, Masahito Ikawa, Masaru Okabe

Scientific Reports　Vol. 7　2017年3月3日　研究論文（学術雑誌）

Viable offspring after imaging of Ca2+ oscillations and visualization of the cortical reaction in mouse eggs†.

Satouh Y, Nozawa K, Yamagata K, Fujimoto T, Ikawa M

Biol Reprod.　Vol. 96　No. 3　p. 563-575　2017年3月1日　研究論文（学術雑誌）

Proton pump inhibitors decrease soluble fms-like tyrosine kinase-1 and soluble endoglin secretion, decrease hypertension, and rescue endothelial dysfunction

Kenji Onda, Stephen Tong, Sally Beard, Natalie Binder, Masanaga Muto, Sevvandi N. Senadheera, Laura Parry, Mark Dilworth, Lewis Renshall, Fiona Brownfoot, Roxanne Hastie, Laura Tuohey, Kirsten Palmer, Toshihiko Hirano, Masahito Ikawa, Tu'uhevaha Kaitu'u-Lino, Natalie J. Hannan

Hypertension　Vol. 69　No. 3　p. 457-468　2017年3月1日　研究論文（学術雑誌）

Regulation of intestinal homeostasis by the ulcerative colitis-Associated gene RNF186

Kosuke Fujimoto, Makoto Kinoshita, Hiroo Tanaka, Daisuke Okuzaki, Yosuke Shimada, Hisako Kayama, Ryu Okumura, Yoki Furuta, Masashi Narazaki, Atsushi Tamura, Shigetsugu Hatakeyama, Masahito Ikawa, Kiichiro Tsuchiya, Mamoru Watanabe, Atsushi Kumanogoh, Sachiko Tsukita, Kiyoshi Takeda

Mucosal Immunology　Vol. 10　No. 2　p. 446-459　2017年3月1日　研究論文（学術雑誌）

Testis-Specific Histone Variant H3t Gene Is Essential for Entry into Spermatogenesis

Jun Ueda, Akihito Harada, Takashi Urahama, Shinichi Machida, Kazumitsu Maehara, Masashi Hada, Yoshinori Makino, Jumpei Nogami, Naoki Horikoshi, Akihisa Osakabe, Hiroyuki Taguchi, Hiroki Tanaka, Hiroaki Tachiwana, Tatsuma Yao, Minami Yamada, Takashi Iwamoto, Ayako Isotani, Masahito Ikawa, Taro Tachibana, Yuki Okada, Hiroshi Kimura, Yasuyuki Ohkawa, Hitoshi Kurumizaka, Kazuo Yamagata

Cell Reports　Vol. 18　No. 3　p. 593-600　2017年1月17日　研究論文（学術雑誌）

Muscle-specific deletion of BDK amplifies loss of myofibrillar protein during protein undernutrition

Takuya Ishikawa, Yasuyuki Kitaura, Yoshihiro Kadota, Yukako Morishita, Miki Ota, Fumiya Yamanaka, Minjun Xu, Masahito Ikawa, Naokazu Inoue, Fuminori Kawano, Naoya Nakai, Taro Murakami, Shinji Miura, Yukino Hatazawa, Yasutomi Kamei, Yoshiharu Shimomura

Scientific Reports　Vol. 7　2017年1月4日　研究論文（学術雑誌）

Mouse spermatozoa with higher fertilization rates have thinner nuclei

Daisuke Mashiko, Masahito Ikawa, Koichi Fujimoto

PeerJ　Vol. 2017　No. 10　2017年　研究論文（学術雑誌）

A delayed sperm penetration of cumulus layers by disruption of acrosin gene in rats^†

Ayako Isotani, Takafumi Matsumura, Masaki Ogawa, Takahiro Tanaka, Kazuo Yamagata, Masahito Ikawa, Masaru Okabe

Biology of Reproduction　Vol. 97　No. 1　p. 61-68　2017年　研究論文（学術雑誌）

Genome editing in mouse zygotes and embryonic stem cells by introducing SgRNA/Cas9 expressing plasmids

Taichi Noda, Asami Oji, Masahito Ikawa

Methods in Molecular Biology　Vol. 1630　p. 67-80　2017年　論文集(書籍)内論文

STING in tumor and host cells cooperatively work for NK cell-mediated tumor growth retardation

Ken Takashima, Yohei Takeda, Hiroyuki Oshiumi, Hiroaki Shime, Masaru Okabe, Masahito Ikawa, Misako Matsumoto, Tsukasa Seya

Biochemical and Biophysical Research Communications　Vol. 478　No. 4　p. 1764-1771　2016年9月30日　研究論文（学術雑誌）

マウスを用いた微小重力環境応答の網羅的解析 マウス軌道上飼育装置の開発と評価

岡田 理沙, 新保 未来, 工藤 崇, 浅野 圭吾, 今村 優希, 綱川 祐貴, 全 孝静, 濱田 理人, 水野 聖哉, 八神 健一, 志賀 隆, 石田 純治, 深水 昭吉, 伊川 正人, 森田 啓之, 篠原 正浩, 浅原 弘嗣, 秋山 泰身, 吉田 進昭, 栗崎 晃, 芝 大

日本生化学会大会プログラム・講演要旨集　Vol. 89回　p. [3P-386]　2016年9月

CRISPR/Cas9 mediated genome editing in ES cells and its application for chimeric analysis in mice

Asami Oji, Taichi Noda, Yoshitaka Fujihara, Haruhiko Miyata, Yeon Joo Kim, Masanaga Muto, Kaori Nozawa, Takafumi Matsumura, Ayako Isotani, Masahito Ikawa

Scientific Reports　Vol. 6　2016年8月17日　研究論文（学術雑誌）

Structural and functional insights into IZUMO1 recognition by JUNO in mammalian fertilization

Kazuki Kato, Yuhkoh Satouh, Hiroshi Nishimasu, Arisa Kurabayashi, Junko Morita, Yoshitaka Fujihara, Asami Oji, Ryuichiro Ishitani, Masahito Ikawa, Osamu Nureki

Nature Communications　Vol. 7　2016年7月15日　研究論文（学術雑誌）

Essential role of autoactivation circuitry on Aurora B-mediated H2AX-pS121 in mitosis

Midori Shimada, Takahiro Goshima, Hiromi Matsuo, Yoshikazu Johmura, Mayumi Haruta, Kazuhiro Murata, Hiromitsu Tanaka, Masahito Ikawa, Keiko Nakanishi, Makoto Nakanishi

Nature Communications　Vol. 7　2016年7月8日　研究論文（学術雑誌）

Regulation of intestinal homeostasis by the ulcerative colitis-associated gene RNF186.

Fujimoto K, Kinoshita M, Tamura A, Tanaka H, Okuzaki D, Shimada Y, Kayama H, Okumura R, Furuta Y, Narazaki M, Hatakeyama S, Ikawa M, Tsuchiya K, Watanabe M, Kumanogoh A, Tsukita S, Takeda K

Mucosal Immunol.　2016年7月　研究論文（学術雑誌）

Biogenesis of sperm acrosome is regulated by pre-mRNA alternative splicing of acrbp in the mouse

Yoshinori Kanemori, Yoshitaka Koga, Mai Sudo, Woojin Kang, Shin Ichi Kashiwabara, Masahito Ikawa, Hidetoshi Hasuwa, Kiyoshi Nagashima, Yu Ishikawa, Narumi Ogonuki, Atsuo Ogura, Tadashi Baba

Proceedings of the National Academy of Sciences of the United States of America　Vol. 113　No. 26　p. E3696-E3705　2016年6月28日　研究論文（学術雑誌）

Complementary role of CNNM2 in sperm motility and Ca²⁺ influx during capacitation

Daisuke Yamazaki, Yosuke Funato, Haruhiko Miyata, Masahito Ikawa, Hiroaki Miki

Biochemical and Biophysical Research Communications　Vol. 474　No. 3　p. 441-446　2016年6月3日　研究論文（学術雑誌）

Expression of a Synthetic Gene of CTDM by Transgenic Animals

R. Sakai, A. Maeda, R. Matsuura, H. Eguchi, P. Lo, H. Hasuwa, M. Ikawa, K. Nakahata, M. Zenitani, T. Yamamichi, S. Umeda, H. Okuyama, S. Miyagawa

Transplantation Proceedings　Vol. 48　No. 4　p. 1279-1281　2016年5月1日　研究論文（国際会議プロシーディングス）

Knockout of Cytidine Monophospho-N-Acetylneuraminic Acid (CMP-NeuAc) Hydroxylase from Porcine Endothelial Cells by a CRISPR System

R. Sakai, Y. Esaki, H. Hasuwa, M. Ikawa, P. Lo, R. Matsuura, K. Nakahata, M. Zenitani, M. Asada, A. Maeda, H. Eguchi, H. Okuyama, S. Miyagawa

Transplantation Proceedings　Vol. 48　No. 4　p. 1320-1322　2016年5月1日　研究論文（国際会議プロシーディングス）

Human HLA-Ev (147) Expression in Transgenic Animals

R. Matsuura, A. Maeda, R. Sakai, H. Eguchi, P. -C. Lo, H. Hasuwa, M. Ikawa, K. Nakahata, M. Zenitani, T. Yamamichi, S. Umeda, K. Deguchi, H. Okuyama, S. Miyagawa

TRANSPLANTATION PROCEEDINGS　Vol. 48　No. 4　p. 1323-1325　2016年5月　研究論文（学術雑誌）

Kidney-specific knockout of Sav1 in the mouse promotes hyperproliferation of renal tubular epithelium through suppression of the Hippo pathway

Tomoki Kai, Yoshiyuki Tsukamoto, Naoki Hijiya, Akinori Tokunaga, Chisato Nakada, Tomohisa Uchida, Tsutomu Daa, Hidekatsu Iha, Mika Takahashi, Takeo Nomura, Fuminori Sato, Hiromitsu Mimata, Masahito Ikawa, Masao Seto, Keiko Matsuura, Masatsugu Moriyama

Journal of Pathology　Vol. 239　No. 1　p. 97-108　2016年5月1日　研究論文（学術雑誌）

Kidney-specific knockout of Sav1 in the mouse promotes hyperproliferation of renal tubular epithelium through suppression of the Hippo pathway

Tomoki Kai, Yoshiyuki Tsukamoto, Naoki Hijiya, Akinori Tokunaga, Chisato Nakada, Tomohisa Uchida, Tsutomu Daa, Hidekatsu Iha, Mika Takahashi, Takeo Nomura, Fuminori Sato, Hiromitsu Mimata, Masahito Ikawa, Masao Seto, Keiko Matsuura, Masatsugu Moriyama

JOURNAL OF PATHOLOGY　Vol. 239　No. 1　p. 97-108　2016年5月　研究論文（学術雑誌）

Expression of a Synthetic Gene of CTDM by Transgenic Animals

R. Sakai, A. Maeda, R. Matsuura, H. Eguchi, P. Lo, H. Hasuwa, M. Ikawa, K. Nakahata, M. Zenitani, T. Yamamichi, S. Umeda, H. Okuyama, S. Miyagawa

TRANSPLANTATION PROCEEDINGS　Vol. 48　No. 4　p. 1279-1281　2016年5月　研究論文（学術雑誌）

Knockout of Cytidine Monophospho-N-Acetylneuraminic Acid (CMP-NeuAc) Hydroxylase From Porcine Endothelial Cells by a CRISPR System

R. Sakai, Y. Esaki, H. Hasuwa, M. Ikawa, P. Lo, R. Matsuura, K. Nakahata, M. Zenitani, M. Asada, A. Maeda, H. Eguchi, H. Okuyama, S. Miyagawa

TRANSPLANTATION PROCEEDINGS　Vol. 48　No. 4　p. 1320-1322　2016年5月　研究論文（学術雑誌）

Human HLA-Ev (147) Expression in Transgenic Animals

R. Matsuura, A. Maeda, R. Sakai, H. Eguchi, P. C. Lo, H. Hasuwa, M. Ikawa, K. Nakahata, M. Zenitani, T. Yamamichi, S. Umeda, K. Deguchi, H. Okuyama, S. Miyagawa

Transplantation Proceedings　Vol. 48　No. 4　p. 1323-1325　2016年5月1日　研究論文（国際会議プロシーディングス）

The Mg²⁺ transporter CNNM4 regulates sperm Ca²⁺ homeostasis and is essential for reproduction

Daisuke Yamazaki, Haruhiko Miyata, Yosuke Funato, Yoshitaka Fujihara, Masahito Ikawa, Hiroaki Miki

Journal of Cell Science　Vol. 129　No. 9　p. 1940-1949　2016年5月1日　研究論文（学術雑誌）

Calreticulin Regulates Neointima Formation and Collagen Deposition following Carotid Artery Ligation

Kurt A. Zimmerman, Dongqi Xing, Manuel A. Pallero, Ailing Lu, Masahito Ikawa, Leland Black, Kenneth L. Hoyt, Janusz H. Kabarowski, Marek Michalak, Joanne E. Murphy-Ullrich

Journal of Vascular Research　Vol. 52　No. 5　p. 306-320　2016年4月　研究論文（学術雑誌）

Generation of Hprt-disrupted rat through mouse←rat ES chimeras.

Isotani A, Yamagata K, Okabe M, Ikawa M

Sci Rep.　Vol. 6　2016年4月　研究論文（学術雑誌）

Fertilization defects in sperm from Cysteine-rich secretory protein 2 (Crisp2) knockout mice: implications for fertility disorders

N. G. Brukman, H. Miyata, P. Torres, D. Lombardo, J. J. Caramelo, M. Ikawa, V. G. Da Ros, P. S. Cuasnicu

MOLECULAR HUMAN REPRODUCTION　Vol. 22　No. 4　p. 240-251　2016年4月　研究論文（学術雑誌）

Behavior of mouse spermatozoa in the female reproductive tract from soon after mating to the beginning of fertilization

Yuko Muro, Hidetoshi Hasuwa, Ayako Isotani, Haruhiko Miyata, Kazuo Yamagata, Masahito Ikawa, Ryuzo Yanagimachi, Masaru Okabe

Biology of Reproduction　Vol. 94　No. 4　p. 1193-1207　2016年4月　研究論文（学術雑誌）

Fertilization defects in sperm from Cysteine-rich secretory protein 2 (Crisp2) knockout mice: Implications for fertility disorders

N. G. Brukman, H. Miyata, P. Torres, D. Lombardo, J. J. Caramelo, M. Ikawa, V. G. Da Ros, P. S. Cuasnicú

Molecular Human Reproduction　Vol. 22　No. 4　p. 240-251　2016年4月　研究論文（学術雑誌）

GPI-AP release in cellular, developmental, and reproductive biology

Yoshitaka Fujihara, Masahito Ikawa

Journal of Lipid Research　Vol. 57　No. 4　p. 538-545　2016年4月

CABYR is essential for fibrous sheath integrity and progressive motility in mouse spermatozoa

Samantha A.M. Young, Haruhiko Miyata, Yuhkoh Satouh, Robert John Aitken, Mark A. Baker, Masahito Ikawa

Journal of Cell Science　Vol. 129　No. 23　p. 4379-4387　2016年　研究論文（学術雑誌）

CRISPR/CAS9-mediated mutation revealed cytoplasmic tail is dispensable for IZUMO1 function and male fertility

Samantha A.M. Young, Haruhiko Miyata, Yuhkoh Satouh, Masanaga Muto, Martin R. Larsen, R. John Aitken, Mark A. Baker, Masahito Ikawa

Reproduction　Vol. 152　No. 6　p. 665-672　2016年　研究論文（学術雑誌）

Lentiviral vector-mediated complementation restored fetal viability but not placental hyperplasia in Plac1-deficient mice

Masanaga Muto, Yoshitaka Fujihara, Tomohiro Tobita, Daiji Kiyozumi, Masahito Ikawa

Biology of Reproduction　Vol. 94　No. 1　2016年1月1日　研究論文（学術雑誌）

A role of TMEM16E carrying a scrambling domain in sperm motility

Sayuri Gyobu, Haruhiko Miyata, Masahito Ikawa, Daiju Yamazaki, Hiroshi Takeshima, Jun Suzuki, Shigekazu Nagata

Molecular and Cellular Biology　Vol. 36　No. 4　p. 645-659　2016年　研究論文（学術雑誌）

Ground-based assessment of JAXA mouse habitat cage unit by mouse phenotypic studies

Miki Shimbo, Takashi Kudo, Michito Hamada, Hyojung Jeon, Yuki Imamura, Keigo Asano, Risa Okada, Yuki Tsunakawa, Seiya Mizuno, Ken Ichi Yagami, Chihiro Ishikawa, Haiyan Li, Takashi Shiga, Junji Ishida, Juri Hamada, Kazuya Murata, Tomohiro Ishimaru, Misuzu Hashimoto, Akiyoshi Fukamizu, Mutsumi Yamane, Masahito Ikawa, Hironobu Morita, Masahiro Shinohara, Hiroshi Asahara, Taishin Akiyama, Nobuko Akiyama, Hiroki Sasanuma, Nobuaki Yoshida, Rui Zhou, Ying Ying Wang, Taito Ito, Yuko Kokubu, Taka Aki K. Noguchi, Hisako Ishimine, Akira Kurisaki, Dai Shiba, Hiroyasu Mizuno, Masaki Shirakawa, Naoki Ito, Shin’Ichi Takeda, Satoru Takahashi

Experimental Animals　Vol. 65　No. 2　p. 175-187　2016年　研究論文（学術雑誌）

A GPI processing phospholipase A2, PGAP6, modulates Nodal signaling in embryos by shedding CRIPTO

Gun Hee Lee, Morihisa Fujita, Katsuyoshi Takaoka, Yoshiko Murakami, Yoshitaka Fujihara, Noriyuki Kanzawa, Kei Ichi Murakami, Eriko Kajikawa, Yoko Takada, Kazunobu Saito, Masahito Ikawa, Hiroshi Hamada, Yusuke Maeda, Taroh Kinoshita

Journal of Cell Biology　Vol. 215　No. 5　p. 705-718　2016年　研究論文（学術雑誌）

新規GPI切断酵素であるPGAP6はCRIPTOのnon-cell-autonomousなNodal副受容体機能を起こす

Lee Gun-Hee, 藤田 盛久, 高岡 勝吉, 村上 良子, 藤原 祥高, 伊川 正人, 濱田 博司, 前田 裕輔, 木下 タロウ

日本生化学会大会・日本分子生物学会年会合同大会講演要旨集　Vol. 88回・38回　p. [2T特-04(2P0321)]　2015年12月

精子受精能獲得時のCatSperチャネルを介したカルシウム流入におけるCNNM4の役割

山崎 大輔, 宮田 治彦, 船戸 洋佑, 藤原 祥高, 伊川 正人, 三木 裕明

日本生化学会大会・日本分子生物学会年会合同大会講演要旨集　Vol. 88回・38回　p. [2T17-12(2P0941)]　2015年12月

Elf5-centered transcription factor hub controls trophoblast stem cell self-renewal and differentiation through stoichiometry sensitive shifts in target gene networks

Paulina A. Latos, Arnold R. Sienerth, Alexander Murray, Claire E. Senner, Masanaga Muto, Masahito Ikawa, David Oxley, Sarah Burge, Brian J. Cox, Myriam Hemberger

Genes and Development　Vol. 29　No. 23　p. 2435-2448　2015年12月1日　研究論文（学術雑誌）

CRISPR/Cas9-mediated rapid generation of multiple mouse lines identified Ccdc63 as essential for spermiogenesis

Samantha A.M. Young, Haruhiko Miyata, Yuhkoh Satouh, Hirotaka Kato, Kaori Nozawa, Ayako Isotani, R. John Aitken, Mark A. Baker, Masahito Ikawa

International Journal of Molecular Sciences　Vol. 16　No. 10　p. 24732-24750　2015年10月16日　研究論文（学術雑誌）

Calcitonin Receptor Signaling Inhibits Muscle Stem Cells from Escaping the Quiescent State and the Niche

Masahiko Yamaguchi, Yoko Watanabe, Takuji Ohtani, Akiyoshi Uezumi, Norihisa Mikami, Miki Nakamura, Takahiko Sato, Masahito Ikawa, Mikio Hoshino, Kunihiro Tsuchida, Yuko Miyagoe-Suzuki, Kazutake Tsujikawa, Shin'ichi Takeda, Hiroshi Yamamoto, So ichiro Fukada

Cell Reports　Vol. 13　No. 2　p. 302-314　2015年10月13日　研究論文（学術雑誌）

Sperm postacrosomal WW domain-binding protein is not required for mouse egg activation

Yuhkoh Satouh, Kaori Nozawa, Masahito Ikawa

Biology of Reproduction　Vol. 93　No. 4　2015年10月1日　研究論文（学術雑誌）

Sperm postacrosomal WW domain-binding protein is not required for mouse egg activation

Yuhkoh Satouh, Kaori Nozawa, Masahito Ikawa

Biology of Reproduction　Vol. 93　No. 4　2015年10月1日　研究論文（学術雑誌）

Calcitonin Receptor Signaling Inhibits Muscle Stem Cells from Escaping the Quiescent State and the Niche

Masahiko Yamaguchi, Yoko Watanabe, Takuji Ohtani, Akiyoshi Uezumi, Norihisa Mikami, Miki Nakamura, Takahiko Sato, Masahito Ikawa, Mikio Hoshino, Kunihiro Tsuchida, Yuko Miyagoe-Suzuki, Kazutake Tsujikawa, Shin'ichi Takeda, Hiroshi Yamamoto, So-ichiro Fukada

CELL REPORTS　Vol. 13　No. 2　p. 302-314　2015年10月　研究論文（学術雑誌）

Calreticulin is required for development of the cumulus oocyte complex and female fertility

Keizo Tokuhiro, Yuhkoh Satouh, Kaori Nozawa, Ayako Isotani, Yoshitaka Fujihara, Yumiko Hirashima, Hiroyuki Matsumura, Kazuhiro Takumi, Takashi Miyano, Masaru Okabe, Adam M. Benham, Masahito Ikawa

Scientific Reports　Vol. 5　2015年9月21日　研究論文（学術雑誌）

Double strand break repair by capture of retrotransposon sequences and reverse-transcribed spliced mRNA sequences in mouse zygotes

Ryuichi Ono, Masayuki Ishii, Yoshitaka Fujihara, Moe Kitazawa, Takako Usami, Tomoko Kaneko-Ishino, Jun Kanno, Masahito Ikawa, Fumitoshi Ishino

Scientific Reports　Vol. 5　2015年7月28日　研究論文（学術雑誌）

Advantages of using the CRISPR/Cas9 system of genome editing to investigate male reproductive mechanisms using mouse models

Samantha A.M. Young, R. John Aitken, Masahito Ikawa

Asian Journal of Andrology　Vol. 17　No. 4　p. 623-627　2015年7月　研究論文（国際会議プロシーディングス）

APJ Regulates Parallel Alignment of Arteries and Veins in the Skin

Hiroyasu Kidoya, Hisamichi Naito, Fumitaka Muramatsu, Daishi Yamakawa, Weizhen Jia, Masahito Ikawa, Takashi Sonobe, Hirotsugu Tsuchimochi, Mikiyasu Shirai, Ralf H. Adams, Akiyoshi Fukamizu, Nobuyuki Takakura

Developmental Cell　Vol. 33　No. 3　p. 247-259　2015年5月4日　研究論文（学術雑誌）

A novel transcriptional factor Nkapl is a germ cell-specific suppressor of Notch signaling and is indispensable for spermatogenesis

Hidenobu Okuda, Hiroshi Kiuchi, Tetsuya Takao, Yasushi Miyagawa, Akira Tsujimura, Norio Nonomura, Haruhiko Miyata, Masaru Okabe, Masahito Ikawa, Yoshitaka Kawakami, Naoki Goshima, Morimasa Wada, Hiromitsu Tanaka

PLoS ONE　Vol. 10　No. 4　2015年4月　研究論文（学術雑誌）

Quantitative assessment of telomerase components in cancer cell lines

Semih Can Akincilar, Kee Chung Low, Chia Yi Liu, Ting Dong Yan, Asami Oji, Masahito Ikawa, Shang Li, Vinay Tergaonkar

FEBS Letters　Vol. 589　No. 9　p. 974-984　2015年4月　研究論文（学術雑誌）

One-step generation of multiple transgenic mouse lines using an improved Pronuclear Injection-based Targeted Transgenesis (i-PITT)

Masato Ohtsuka, Hiromi Miura, Keiji Mochida, Michiko Hirose, Ayumi Hasegawa, Atsuo Ogura, Ryuta Mizutani, Minoru Kimura, Ayako Isotani, Masahito Ikawa, Masahiro Sato, Channabasavaiah B. Gurumurthy

BMC GENOMICS　Vol. 16　No. 1　2015年4月　研究論文（学術雑誌）

A Novel Transcriptional Factor Nkapl Is a Germ Cell-Specific Suppressor of Notch Signaling and Is Indispensable for Spermatogenesis

Hidenobu Okuda, Hiroshi Kiuchi, Tetsuya Takao, Yasushi Miyagawa, Akira Tsujimura, Norio Nonomura, Haruhiko Miyata, Masaru Okabe, Masahito Ikawa, Yoshitaka Kawakami, Naoki Goshima, Morimasa Wada, Hiromitsu Tanaka

PLOS ONE　Vol. 10　No. 4　2015年4月　研究論文（学術雑誌）

One-step generation of multiple transgenic mouse lines using an improved Pronuclear Injection-based Targeted Transgenesis (i-PITT)

Masato Ohtsuka, Hiromi Miura, Keiji Mochida, Michiko Hirose, Ayumi Hasegawa, Atsuo Ogura, Ryuta Mizutani, Minoru Kimura, Ayako Isotani, Masahito Ikawa, Masahiro Sato, Channabasavaiah B. Gurumurthy

BMC Genomics　Vol. 16　No. 1　2015年4月　研究論文（学術雑誌）

Genome editing in mice using crispr/cas

A. M.Samantha Young, Mark Baker, Masahito Ikawa

Targeted Genome Editing Using Site-Specific Nucleases: ZFNs, TALENs, and the CRISPR/Cas9 System　p. 151-166　2015年1月1日　論文集(書籍)内論文

Pluripotent stem cells derived from mouse primordial germ cells by small molecule compounds

Tohru Kimura, Yoshiaki Kaga, Yoichi Sekita, Keita Fujikawa, Tsunetoshi Nakatani, Mika Odamoto, Soichiro Funaki, Masahito Ikawa, Kuniya Abe, Toru Nakano

Stem Cells　Vol. 33　No. 1　p. 45-55　2015年1月1日　研究論文（学術雑誌）

Single-step generation of rabbits carrying a targeted allele of the tyrosinase gene using CRISPR/Cas9

Arata Honda, Michiko Hirose, Tadashi Sankai, Lubna Yasmin, Kazuaki Yuzawa, Kimiko Honsho, Haruna Izu, Atsushi Iguchi, Masahito Ikawa, Atsuo Ogura

Experimental Animals　Vol. 64　No. 1　p. 31-37　2015年　研究論文（学術雑誌）

Concurrent production of multiple targeted transgenic mouse lines with C57BL/6N genetic background by improved PITT

Masato Ohtsuka, Hiromi Miura, Minoru Kimura, Ayako Isotani, Masahito Ikawa, Masahiro Sato, Channabasavaiah Gurumurthy

TRANSGENIC RESEARCH　Vol. 23　No. 5　p. 855-856　2014年10月

RHOF PROMOTES MURINE MARGINAL ZONE B CELL DEVELOPMENT

Mayuko Kishimoto, Takenori Matsuda, Shougo Yanase, Akira Katsumi, Nobuaki Suzuki, Makoto Ikejiri, Akira Takagi, Masahito Ikawa, Tetsuhito Kojima, Shinji Kunishima, Hitoshi Kiyoi, Tomoki Naoe, Tadashi Matsushita, Mitsuo Maruyama

NAGOYA JOURNAL OF MEDICAL SCIENCE　Vol. 76　No. 3-4　p. 293-305　2014年8月　研究論文（学術雑誌）

Simple generation of albino C57BL/6J mice with G291T mutation in the tyrosinase gene by the CRISPR/Cas9 system

Seiya Mizuno, Tra Thi Huong Dinh, Kanako Kato, Saori Mizuno-Iijima, Yoko Tanimoto, Yoko Daitoku, Yoshikazu Hoshino, Masahito Ikawa, Satoru Takahashi, Fumihiro Sugiyama, Ken Ichi Yagami

Mammalian Genome　Vol. 25　No. 7-8　p. 327-334　2014年8月　研究論文（学術雑誌）

Deletion of N-myc downstream-regulated gene 2 attenuates reactive astrogliosis and inflammatory response in a mouse model of cortical stab injury

Mika Takarada-Iemata, Dai Kezuka, Toshiaki Takeichi, Masahito Ikawa, Tsuyoshi Hattori, Yasuko Kitao, Osamu Hori

Journal of Neurochemistry　Vol. 130　No. 3　p. 374-387　2014年8月　研究論文（学術雑誌）

NUCKS Is a Positive Transcriptional Regulator of Insulin Signaling

Beiying Qiu, Xiaohe Shi, Ee Tsin Wong, Joy Lim, Marco Bezzi, Diana Low, Qiling Zhou, Semih Can Akincilar, Manikandan Lakshmanan, Hannah L.F. Swa, Jill Mae Lan Tham, Jayantha Gunaratne, Kenneth K.Y. Cheng, Wanjin Hong, Karen S.L. Lam, Masahito Ikawa, Ernesto Guccione, Aimin Xu, Weiping Han, Vinay Tergaonkar

Cell Reports　Vol. 7　No. 6　p. 1876-1886　2014年6月26日　研究論文（学術雑誌）

GPI-anchored protein complex, LY6K/TEX101, is required for sperm migration into the oviduct and male fertility in mice1

Yoshitaka Fujihara, Masaru Okabe, Masahito Ikawa

Biology of Reproduction　Vol. 90　No. 3　2014年3月　研究論文（学術雑誌）

Liver-Specific γ-Glutamyl Carboxylase-Deficient Mice Display Bleeding Diathesis and Short Life Span.

Azuma K, Tsukui T, Ikeda K, Shiba S, Nakagawa K, Okano T, Urano T, Horie-Inoue K, Ouchi Y, Ikawa M, Inoue S

PLoS One.　Vol. 9　No. 2　2014年2月10日　研究論文（学術雑誌）

Effect of isolated AMP deaminase deficiency on skeletal muscle function

Jidong Cheng, Hiroko Morisaki, Naomi Sugimoto, Atsushi Dohi, Takuya Shintani, Erika Kimura, Keiko Toyama, Masahito Ikawa, Masaru Okabe, Itsuro Higuchi, Satoshi Matsuo, Yasuaki Kawai, Ichiro Hisatome, Takako Sugama, Edward W. Holmes, Takayuki Morisaki

Molecular Genetics and Metabolism Reports　Vol. 1　No. 1　p. 51-59　2014年　研究論文（学術雑誌）

CRISPR/Cas9-based genome editing in mice by single plasmid injection

Yoshitaka Fujihara, Masahito Ikawa

Methods in Enzymology　Vol. 546　No. C　p. 319-336　2014年　論文集(書籍)内論文

RHOF promotes murine marginal zone B cell development

Mayuko Kishimoto, Takenori Matsuda, Shougo Yanase, Akira Katsumi, Nobuaki Suzuki, Makoto Ikejiri, Akira Takagi, Masahito Ikawa, Tetsuhito Kojima, Shinji Kunishima, Hitoshi Kiyoi, Tomoki Naoe, Tadashi Matsushita, Mitsuo Maruyama

Nagoya Journal of Medical Science　Vol. 76　No. 3-4　p. 293-305　2014年　研究論文（学術雑誌）

Effect of isolated AMP deaminase deficiency on skeletal muscle function

Jidong Cheng, Hiroko Morisaki, Naomi Sugimoto, Atsushi Dohi, Takuya Shintani, Erika Kimura, Keiko Toyama, Masahito Ikawa, Masaru Okabe, Itsuro Higuchi, Satoshi Matsuo, Yasuaki Kawai, Ichiro Hisatome, Takako Sugama, Edward W. Holmes, Takayuki Morisaki

Molecular Genetics and Metabolism Reports　Vol. 1　No. 1　p. 51-59　2014年　研究論文（学術雑誌）

CRISPR/Cas9-based genome editing in mice by single plasmid injection

Yoshitaka Fujihara, Masahito Ikawa

Methods in Enzymology　Vol. 546　No. C　p. 319-336　2014年　研究論文（学術雑誌）

Effect of isolated AMP deaminase deficiency on skeletal muscle function

Jidong Cheng, Hiroko Morisaki, Naomi Sugimoto, Atsushi Dohi, Takuya Shintani, Erika Kimura, Keiko Toyama, Masahito Ikawa, Masaru Okabe, Itsuro Higuchi, Satoshi Matsuo, Yasuaki Kawai, Ichiro Hisatome, Takako Sugama, Edward W. Holmes, Takayuki Morisaki

Molecular Genetics and Metabolism Reports　Vol. 1　No. 1　p. 51-59　2014年　研究論文（学術雑誌）

GPI-anchored protein complex, LY6K/TEX101, is required for sperm migration into the oviduct and male fertility in mice1

Yoshitaka Fujihara, Masaru Okabe, Masahito Ikawa

Biology of Reproduction　Vol. 90　No. 3　2014年　研究論文（学術雑誌）

Feasibility for a large scale mouse mutagenesis by injecting CRISPR/Cas plasmid into zygotes

Daisuke Mashiko, Samantha A.M. Young, Masanaga Muto, Hirotaka Kato, Kaori Nozawa, Masaki Ogawa, Taichi Noda, Yeon Joo Kim, Yuhkoh Satouh, Yoshitaka Fujihara, Masahito Ikawa

Development Growth and Differentiation　Vol. 56　No. 1　p. 122-129　2014年1月　研究論文（学術雑誌）

Generation of mutant mice by pronuclear injection of circular plasmid expressing Cas9 and single guided RNA

Daisuke Mashiko, Yoshitaka Fujihara, Yuhkoh Satouh, Haruhiko Miyata, Ayako Isotani, Masahito Ikawa

Scientific Reports　Vol. 3　2013年11月27日　研究論文（学術雑誌）

Targeted disruption of fad24, a regulator of adipogenesis, causes pre-implantation embryonic lethality due to the growth defect at the blastocyst stage

Natsuki Ochiai, Makoto Nishizuka, Tomomi Miyamoto, Ichiro Miyoshi, Masahito Ikawa, Shigehiro Osada, Masayoshi Imagawa

Biochemical and Biophysical Research Communications　Vol. 438　No. 2　p. 301-305　2013年8月23日　研究論文（学術雑誌）

Establishment of Mouse Model of MYH9 Disorders: Heterozygous R702C Mutation Provokes Macrothrombocytopenia with Leukocyte Inclusion Bodies, Renal Glomerulosclerosis and Hearing Disability

Nobuaki Suzuki, Shinji Kunishima, Makoto Ikejiri, Shoichi Maruyama, Michihiko Sone, Akira Takagi, Masahito Ikawa, Masaru Okabe, Tetsuhito Kojima, Hidehiko Saito, Tomoki Naoe, Tadashi Matsushita

PLoS ONE　Vol. 8　No. 8　2013年8月20日　研究論文（学術雑誌）

Macrophage MHC and T-Cell receptors essential for rejection of allografted skin and lymphoma

Junko Tashiro-Yamaji, Shogo Maeda, Masahito Ikawa, Masaru Okabe, Takahiro Kubota, Ryotaro Yoshida

Transplantation　Vol. 96　No. 3　p. 251-257　2013年8月15日　研究論文（学術雑誌）

Molecular dissection of IZUMO1, a sperm protein essential for sperm-egg fusion

Naokazu Inoue, Daizo Hamada, Hironari Kamikubo, Kunio Hirata, Mikio Kataoka, Masaki Yamamoto, Masahito Ikawa, Masaru Okabe, Yoshihisa Hagihara

Development (Cambridge)　Vol. 140　No. 15　p. 3221-3229　2013年8月1日　研究論文（学術雑誌）

臨床移植用遺伝子改変ブタ

宮川 周士, 前田 晃, 河村 拓司, 中畠 賢吾, 上野 豪久, 臼井 規朗, 伊川 正人, 岡部 勝, 長島 比呂志

補体シンポジウム講演集　Vol. 50　p. 58-59　2013年7月

Recruitment of cyclin G2 to promyelocytic leukemia nuclear bodies promotes dephosphorylation of γH2AX following treatment with ionizing radiation.

Naito Y, Yabuta N, Sato J, Ohno S, Sakata M, Kasama T, Ikawa M, Nojima H

Cell cycle (Georgetown, Tex.)　Vol. 12　No. 11　p. 1773-1784　2013年6月1日　研究論文（学術雑誌）

Functional and structural study of mouse sperm protein, IZUMO1, by using molecular dissection

Naokazu Inoue, Daizo Hamada, Hironari Kamikubo, Kunio Hirata, Mikio Kataoka, Masaki Yamamoto, Masahito Ikawa, Masaru Okabe, Yoshihisa Hagihara

Development　Vol. 140　No. 15　p. 3221-3229　2013年　研究論文（その他学術会議資料等）

Production of mouse pups from germline transmission-failed knockout chimeras

Yoshitaka Fujihara, Kazuhiro Kaseda, Naokazu Inoue, Masahito Ikawa, Masaru Okabe

Transgenic Research　Vol. 22　No. 1　p. 195-200　2013年　研究論文（学術雑誌）

Neutrophil infiltration during inflammation is regulated by PILRα via modulation of integrin activation.

Wang J, Shiratori I, Uehori J, Ikawa M, Arase H

Nature immunology　Vol. 14　No. 1　p. 34-40　2013年1月　研究論文（学術雑誌）

N-terminal truncation of Lats1 causes abnormal cell growth control and chromosomal instability

Norikazu Yabuta, Satomi Mukai, Ayumi Okamoto, Daisuke Okuzaki, Hirokazu Suzuki, Kosuke Torigata, Kaori Yoshida, Nobuhiro Okada, Daisaku Miura, Akihiko Ito, Masahito Ikawa, Masaru Okabe, Hiroshi Nojima

Journal of Cell Science　Vol. 126　No. 2　p. 508-519　2013年1月　研究論文（学術雑誌）

A point mutation in Semaphorin 4A associates with defective endosomal sorting and causes retinal degeneration

Satoshi Nojima, Toshihiko Toyofuku, Hiroyuki Kamao, Chie Ishigami, Jun Kaneko, Tatsusada Okuno, Hyota Takamatsu, Daisuke Ito, Sujin Kang, Tetsuya Kimura, Yuji Yoshida, Keiko Morimoto, Yohei Maeda, Atsushi Ogata, Masahito Ikawa, Eiichi Morii, Katsuyuki Aozasa, Junichi Takagi, Masayo Takahashi, Atsushi Kumanogoh

Nature Communications　Vol. 4　2013年　研究論文（学術雑誌）

Mice deficient in ficolin, a lectin complement pathway recognition molecule, are susceptible to Streptococcus pneumoniae infection

Yuichi Endo, Minoru Takahashi, Daisuke Iwaki, Yumi Ishida, Naomi Nakazawa, Toshihisa Kodama, Tomohiro Matsuzaka, Kazuko Kanno, Yu Liu, Kohsuke Tsuchiya, Ikuo Kawamura, Masahito Ikawa, Satoshi Waguri, Ikuo Wada, Misao Matsushita, Wilhelm J. Schwaeble, Teizo Fujita

Journal of Immunology　Vol. 189　No. 12　p. 5860-5866　2012年12月15日　研究論文（学術雑誌）

AMPD3-deficient mice exhibit increased erythrocyte ATP levels but anemia not improved due to PK deficiency

Jidong Cheng, Hiroko Morisaki, Keiko Toyama, Masahito Ikawa, Masaru Okabe, Takayuki Morisaki

Genes to Cells　Vol. 17　No. 11　p. 913-922　2012年11月　研究論文（学術雑誌）

SPACA1-deficient male mice are infertile with abnormally shaped sperm heads reminiscent of globozoospermia

Yoshitaka Fujihara, Yuhkoh Satouh, Naokazu Inoue, Ayako Isotani, Masahito Ikawa, Masaru Okabe

Development (Cambridge)　Vol. 139　No. 19　p. 3583-3589　2012年10月1日　研究論文（学術雑誌）

Tetraspanin-interacting protein IGSF8 is dispensable for mouse fertility

Naokazu Inoue, Takao Nishikawa, Masahito Ikawa, Masaru Okabe

Fertility and Sterility　Vol. 98　No. 2　p. 465-470　2012年8月　研究論文（学術雑誌）

GPHR-dependent functions of the golgi apparatus are essential for the formation of lamellar granules and the skin barrier

Masahito Tarutani, Kimiko Nakajima, Yoshikazu Uchida, Mikiro Takaishi, Naoko Goto-Inoue, Masahito Ikawa, Mitsutoshi Setou, Taroh Kinoshita, Peter M. Elias, Shigetoshi Sano, Yusuke Maeda

Journal of Investigative Dermatology　Vol. 132　No. 8　p. 2019-2025　2012年8月　研究論文（学術雑誌）

Mice expressing aberrant sperm-specific protein PMIS2 produce normal-looking but fertilization-incompetent spermatozoa

Ryo Yamaguchi, Yoshitaka Fujiharaa, Masahito Ikawa, Masaru Okabe

Molecular Biology of the Cell　Vol. 23　No. 14　p. 2671-2679　2012年7月15日　研究論文（学術雑誌）

Cold-inducible RNA-binding protein (Cirp) interacts with Dyrk1b/Mirk and promotes proliferation of immature male germ cells in mice

Tomoko Masuda, Katsuhiko Itoh, Hiroaki Higashitsuji, Hisako Higashitsuji, Noa Nakazawa, Toshiharu Sakurai, Yu Liu, Hiromu Tokuchi, Takanori Fujita, Yan Zhao, Hiroyuki Nishiyama, Takashi Tanaka, Manabu Fukumoto, Masahito Ikawa, Masaru Okabe, Jun Fujita

Proceedings of the National Academy of Sciences of the United States of America　Vol. 109　No. 27　p. 10885-10890　2012年7月3日　研究論文（学術雑誌）

Characterization of inclusion bodies with cytoprotective properties formed by seipinopathy-linked mutant seipin

Daisuke Ito, Takuya Yagi, Masahito Ikawa, Norihiro Suzuki

Human Molecular Genetics　Vol. 21　No. 3　p. 635-646　2012年2月　研究論文（学術雑誌）

Visualization of the moment of mouse sperm-egg fusion and dynamic localization of IZUMO1

Yuhkoh Satouh, Naokazu Inoue, Masahito Ikawa, Masaru Okabe

Journal of Cell Science　Vol. 125　No. 21　p. 4985-4990　2012年　研究論文（学術雑誌）

Proteinuria in AMPD2-deficient mice

Keiko Toyama, Hiroko Morisaki, Jidong Cheng, Hiroshi Kawachi, Fujio Shimizu, Masahito Ikawa, Masaru Okabe, Takayuki Morisaki

Genes to Cells　Vol. 17　No. 1　p. 28-38　2012年1月　研究論文（学術雑誌）

Acrosome-reacted mouse spermatozoa recovered from the perivitelline space can fertilize other eggs

Naokazu Inoue, Yuhkoh Satouh, Masahito Ikawa, Masaru Okabe, Ryuzo Yanagimachi

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　Vol. 108　No. 50　p. 20008-20011　2011年12月　研究論文（学術雑誌）

Dynamic modification of sphingomyelin in lipid microdomains controls development of obesity, fatty liver, and type 2 diabetes

Susumu Mitsutake, Kota Zama, Hazuki Yokota, Tetsuya Yoshida, Miki Tanaka, Masaru Mitsui, Masahito Ikawa, Masaru Okabe, Yoshikazu Tanaka, Tadashi Yamashita, Hiroshi Takemoto, Toshiro Okazaki, Ken Watanabe, Yasuyuki Igarashi

Journal of Biological Chemistry　Vol. 286　No. 32　p. 28544-28555　2011年8月12日　研究論文（学術雑誌）

Factor for Adipocyte Differentiation 158 gene disruption prevents the body weight gain and insulin resistance induced by a high-fat diet

Takahiro Hayashi, Yuriko Nozaki, Makoto Nishizuka, Masahito Ikawa, Shigehiro Osada, Masayoshi Imagawa

Biological and Pharmaceutical Bulletin　Vol. 34　No. 8　p. 1257-1263　2011年8月　研究論文（学術雑誌）

Factor for Adipocyte Differentiation 158 Gene Disruption Prevents the Body Weight Gain and Insulin Resistance Induced by a High-Fat Diet

Takahiro Hayashi, Yuriko Nozaki, Makoto Nishizuka, Masahito Ikawa, Shigehiro Osada, Masayoshi Imagawa

BIOLOGICAL & PHARMACEUTICAL BULLETIN　Vol. 34　No. 8　p. 1257-1263　2011年8月　研究論文（学術雑誌）

Dynamic Modification of Sphingomyelin in Lipid Microdomains Controls Development of Obesity, Fatty Liver, and Type 2 Diabetes

Susumu Mitsutake, Kota Zama, Hazuki Yokota, Tetsuya Yoshida, Miki Tanaka, Masaru Mitsui, Masahito Ikawa, Masaru Okabe, Yoshikazu Tanaka, Tadashi Yamashita, Hiroshi Takemoto, Toshiro Okazaki, Ken Watanabe, Yasuyuki Igarashi

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 286　No. 32　p. 28544-28555　2011年8月　研究論文（学術雑誌）

Homologous recombination in rat germline stem cells

Mito Kanatsu-Shinohara, Megumi Kato-Itoh, Masahito Ikawa, Masanori Takehashi, Makoto Sanbo, Yuka Morioka, Takashi Tanaka, Hiroko Morimoto, Masumi Hirabayashi, Takashi Shinohara

Biology of Reproduction　Vol. 85　No. 1　p. 208-217　2011年7月1日　研究論文（学術雑誌）

Homologous Recombination in Rat Germline Stem Cells

Mito Kanatsu-Shinohara, Megumi Kato-Itoh, Masahito Ikawa, Masanori Takehashi, Makoto Sanbo, Yuka Morioka, Takashi Tanaka, Hiroko Morimoto, Masumi Hirabayashi, Takashi Shinohara

BIOLOGY OF REPRODUCTION　Vol. 85　No. 1　p. 208-217　2011年7月　研究論文（学術雑誌）

Targeted disruption of one of the importin α family members leads to female functional incompetence in delivery.

Moriyama T, Nagai M, Oka M, Ikawa M, Okabe M, Yoneda Y

FEBS J.　Vol. 278　No. 9　p. 1561-1572　2011年5月　研究論文（学術雑誌）

Targeted disruption of one of the importin alpha family members leads to female functional incompetence in delivery

Tetsuji Moriyama, Masahiro Nagai, Masahiro Oka, Masahito Ikawa, Masaru Okabe, Yoshihiro Yoneda

FEBS JOURNAL　Vol. 278　No. 9　p. 1561-1572　2011年5月　研究論文（学術雑誌）

Targeted disruption of one of the importin α family members leads to female functional incompetence in delivery.

Moriyama T, Nagai M, Oka M, Ikawa M, Okabe M, Yoneda Y

FEBS J.　2011年5月　研究論文（学術雑誌）

Formation of a thymus from rat ES cells in xenogeneic nude mouse &lt;-&gt; rat ES chimeras

Ayako Isotani, Hide Hatayama, Kazuhiro Kaseda, Masahito Ikawa, Masaru Okabe

GENES TO CELLS　Vol. 16　No. 4　p. 397-405　2011年4月　研究論文（学術雑誌）

Formation of a thymus from rat ES cells in xenogeneic nude mouse &lt;-&gt; rat ES chimeras

Ayako Isotani, Hide Hatayama, Kazuhiro Kaseda, Masahito Ikawa, Masaru Okabe

GENES TO CELLS　Vol. 16　No. 4　p. 397-405　2011年4月　研究論文（学術雑誌）

Formation of a thymus from rat ES cells in xenogeneic nude mouse↔rat ES chimeras

Ayako Isotani, Hide Hatayama, Kazuhiro Kaseda, Masahito Ikawa, Masaru Okabe

Genes to Cells　Vol. 16　No. 4　p. 397-405　2011年4月　研究論文（学術雑誌）

Mice lacking Ran binding protein 1 are viable and show male infertility

Masahiro Nagai, Tetsuji Moriyama, Rashid Mehmood, Keizo Tokuhiro, Masahito Ikawa, Masaru Okabe, Hiromitsu Tanaka, Yoshihiro Yoneda

FEBS Letters　Vol. 585　No. 5　p. 791-796　2011年3月9日　研究論文（学術雑誌）

Mice lacking Ran binding protein 1 are viable and show male infertility

Masahiro Nagai, Tetsuji Moriyama, Rashid Mehmood, Keizo Tokuhiro, Masahito Ikawa, Masaru Okabe, Hiromitsu Tanaka, Yoshihiro Yoneda

FEBS LETTERS　Vol. 585　No. 5　p. 791-796　2011年3月　研究論文（学術雑誌）

Mice lacking Ran binding protein 1 are viable and show male infertility

Masahiro Nagai, Tetsuji Moriyama, Rashid Mehmood, Keizo Tokuhiro, Masahito Ikawa, Masaru Okabe, Hiromitsu Tanaka, Yoshihiro Yoneda

FEBS LETTERS　Vol. 585　No. 5　p. 791-796　2011年3月　研究論文（学術雑誌）

Identification of semaphorin 4B as a negative regulator of basophil-mediated immune responses

Yukinobu Nakagawa, Hyota Takamatsu, Tatsusada Okuno, Sujin Kang, Satoshi Nojima, Tetsuya Kimura, Tatsuki R. Kataoka, Masahito Ikawa, Toshihiko Toyofuku, Ichiro Katayama, Atsushi Kumanogoh

Journal of Immunology　Vol. 186　No. 5　p. 2881-2888　2011年3月1日　研究論文（学術雑誌）

Muscle Fiber Type-Predominant Promoter Activity in Lentiviral-Mediated Transgenic Mouse

Tomohiro Suga, En Kimura, Yuka Morioka, Masahito Ikawa, Sheng Li, Katsuhisa Uchino, Yuji Uchida, Satoshi Yamashita, Yasushi Maeda, Jeffrey S. Chamberlain, Makoto Uchino

PLOS ONE　Vol. 6　No. 3　2011年3月　研究論文（学術雑誌）

Identification of Semaphorin 4B as a Negative Regulator of Basophil-Mediated Immune Responses

Yukinobu Nakagawa, Hyota Takamatsu, Tatsusada Okuno, Sujin Kang, Satoshi Nojima, Tetsuya Kimura, Tatsuki R. Kataoka, Masahito Ikawa, Toshihiko Toyofuku, Ichiro Katayama, Atsushi Kumanogoh

JOURNAL OF IMMUNOLOGY　Vol. 186　No. 5　p. 2881-2888　2011年3月　研究論文（学術雑誌）

Calsperin is a testis-specific chaperone required for sperm fertility

Masahito Ikawa, Keizo Tokuhiro, Ryo Yamaguchi, Adam M. Benham, Taku Tamura, Ikuo Wada, Yuhkoh Satouh, Naokazu Inoue, Masaru Okabe

Journal of Biological Chemistry　Vol. 286　No. 7　p. 5639-5646　2011年2月18日　研究論文（学術雑誌）

Mitochondrial dysfunction and increased reactive oxygen species impair insulin secretion in sphingomyelin synthase 1-null Mice

Masato Yano, Ken Watanabe, Tadashi Yamamoto, Kazutaka Ikeda, Takafumi Senokuchi, Meihong Lu, Tsuyoshi Kadomatsu, Hiroto Tsukano, Masahito Ikawa, Masaru Okabe, Shohei Yamaoka, Toshiro Okazaki, Hisanori Umehara, Tomomi Gotoh, Wen Jie Song, Koichi Node, Ryo Taguchi, Kazuya Yamagata, Yuichi Oike

Journal of Biological Chemistry　Vol. 286　No. 5　p. 3992-4002　2011年2月4日　研究論文（学術雑誌）

Mitochondrial Dysfunction and Increased Reactive Oxygen Species Impair Insulin Secretion in Sphingomyelin Synthase 1-null Mice

Masato Yano, Ken Watanabe, Tadashi Yamamoto, Kazutaka Ikeda, Takafumi Senokuchi, Meihong Lu, Tsuyoshi Kadomatsu, Hiroto Tsukano, Masahito Ikawa, Masaru Okabe, Shohei Yamaoka, Toshiro Okazaki, Hisanori Umehara, Tomomi Gotoh, Wen-Jie Song, Koichi Node, Ryo Taguchi, Kazuya Yamagata, Yuichi Oike

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 286　No. 5　p. 3992-4002　2011年2月　研究論文（学術雑誌）

Mitochondrial Dysfunction and Increased Reactive Oxygen Species Impair Insulin Secretion in Sphingomyelin Synthase 1-null Mice

Masato Yano, Ken Watanabe, Tadashi Yamamoto, Kazutaka Ikeda, Takafumi Senokuchi, Meihong Lu, Tsuyoshi Kadomatsu, Hiroto Tsukano, Masahito Ikawa, Masaru Okabe, Shohei Yamaoka, Toshiro Okazaki, Hisanori Umehara, Tomomi Gotoh, Wen-Jie Song, Koichi Node, Ryo Taguchi, Kazuya Yamagata, Yuichi Oike

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 286　No. 5　p. 3992-4002　2011年2月　研究論文（学術雑誌）

Calsperin Is a Testis-specific Chaperone Required for Sperm Fertility

Masahito Ikawa, Keizo Tokuhiro, Ryo Yamaguchi, Adam M. Benham, Taku Tamura, Ikuo Wada, Yuhkoh Satouh, Naokazu Inoue, Masaru Okabe

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 286　No. 7　p. 5639-5646　2011年2月　研究論文（学術雑誌）

Primary screening of single nucleotide polymorphisms in human Calreticulin 3 (CALR3)

Shinji Irie, Junko Nakamura, Yasushi Miyagawa, Akira Tsujimura, Hidenobu Okuda, Keisuke Yamamoto, Shinichiro Fukuhara, Iwao Yoshioka, Kiuchi Hiroshi, Yasuhiro Matsuoka, Tetsuya Takao, Norio Nonomura, Masahito Ikawa, Keizo Tokuhiro, Masaru Okabe, Tomomi Shibata, Kyoko Fujimoto, Morimasa Wada, Hiromitsu Tanaka

Open Andrology Journal　Vol. 3　p. 30-35　2011年　研究論文（学術雑誌）

The mechanism of sperm-egg interaction and the involvement of IZUMO1 in fusion

Naokazu Inoue, Masahito Ikawa, Masaru Okabe

Asian Journal of Andrology　Vol. 13　No. 1　p. 81-87　2011年1月

The mechanism of sperm-egg interaction and the involvement of IZUMO1 in fusion

Naokazu Inoue, Masahito Ikawa, Masaru Okabe

ASIAN JOURNAL OF ANDROLOGY　Vol. 13　No. 1　p. 81-87　2011年1月

Muscle fiber type-predominant promoter activity in lentiviral-mediated transgenic mouse

Tomohiro Suga, En Kimura, Yuka Morioka, Masahito Ikawa, Sheng Li, Katsuhisa Uchino, Yuji Uchida, Satoshi Yamashita, Yasushi Maeda, Jeffrey S. Chamberlain, Makoto Uchino

PLoS ONE　Vol. 6　No. 3　2011年　研究論文（学術雑誌）

The mechanism of sperm-egg interaction and the involvement of IZUMO1 in fusion

Naokazu Inoue, Masahito Ikawa, Masaru Okabe

ASIAN JOURNAL OF ANDROLOGY　Vol. 13　No. 1　p. 81-87　2011年1月

Calponin 3 regulates actin cytoskeleton rearrangement in trophoblastic cell fusion

Yukinao Shibukawa, Natsuko Yamazaki, Keiichi Kumasawa, Etsuko Daimon, Michiko Tajiri, Yuka Okada, Masahito Ikawa, Yoshinao Wada

Molecular Biology of the Cell　Vol. 21　No. 22　p. 3973-3984　2010年11月15日　研究論文（学術雑誌）

Establishment and analysis of SLC22A12 (URAT1) knockout mouse

M. Hosoyamada, Y. Takiue, H. Morisaki, J. Cheng, M. Ikawa, M. Okabe, T. Morisaki, K. Ichida, T. Hosoya, T. Shibasaki

Nucleosides, Nucleotides and Nucleic Acids　Vol. 29　No. 4-6　p. 314-320　2010年6月　研究論文（学術雑誌）

Sperm equatorial segment protein 1, SPESP1, is required for fully fertile sperm in mouse

Yoshitaka Fujihara, Masao Murakami, Naokazu Inoue, Yuhkoh Satouh, Kazuhiro Kaseda, Masahito Ikawa, Masaru Okabe

Journal of Cell Science　Vol. 123　No. 9　p. 1531-1536　2010年5月1日　研究論文（学術雑誌）

Transgenic mouse sperm that have green acrosome and red mitochondria allow visualization of sperm and their acrosome reaction in vivo

Hidetoshi Hasuwa, Yuko Muro, Masahito Ikawa, Noriko Kato, Yoshihide Tsujimoto, Masaru Okabe

Experimental Animals　Vol. 59　No. 1　p. 105-107　2010年3月11日

Humanized gene replacement in mice reveals the contribution of cancer stroma-derived HB-EGF to tumor growth

Tomoko Ichise, Satoshi Adachi, Minako Ohishi, Masahito Ikawa, Masaru Okabe, Ryo Iwamoto, Eisuke Mekada

Cell Structure and Function　Vol. 35　No. 1　p. 3-13　2010年　研究論文（学術雑誌）

Identification and disruption of sperm-specific angiotensin converting enzyme-3 (ACE3) in mouse

Naokazu Inoue, Tatsuya Kasahara, Masahito Ikawa, Masaru Okabe

PLoS ONE　Vol. 5　No. 4　2010年　研究論文（学術雑誌）

Introduction of a foreign gene into zebrafish and medaka cells using adenoviral vectors

Toshihiro Kawasaki, Kenji Saito, Kaoru Mitsui, Masahito Ikawa, Masakane Yamashita, Yoshihito Taniguchi, Shunichi Takeda, Kohnosuke Mitani, Noriyoshi Sakai

Zebrafish　Vol. 6　No. 3　p. 253-258　2009年9月1日　研究論文（学術雑誌）

L-Amino acid oxidase plays a crucial role in host defense in the mammary glands

Kentaro Nagaoka, Fugaku Aoki, Mizuna Hayashi, Yoshikage Muroi, Toshihiro Sakurai, Kikuji Itoh, Masahito Ikawa, Masaru Okabe, Kazuhiko Imakawa, Senkiti Sakai

FASEB Journal　Vol. 23　No. 8　p. 2514-2520　2009年8月　研究論文（学術雑誌）

A histone H3 lysine 36 trimethyltransferase links Nkx2-5 to Wolf-Hirschhorn syndrome

Keisuke Nimura, Kiyoe Ura, Hidetaka Shiratori, Masato Ikawa, Masaru Okabe, Robert J. Schwartz, Yasufumi Kaneda

Nature　Vol. 460　No. 7252　p. 287-291　2009年7月9日　研究論文（学術雑誌）

Disruption of ADAM3 impairs the migration of sperm into oviduct in mouse

Ryo Yamaguchi, Yuko Muro, Ayako Isotani, Keizo Tokuhiro, Kazuhiro Takumi, Ibrahim Adham, Masahito Ikawa, Masaru Okabe

Biology of Reproduction　Vol. 81　No. 1　p. 142-146　2009年7月　研究論文（学術雑誌）

Peroxiredoxin 4 knockout results in elevated spermatogenic cell death via oxidative stress

Yoshihito Iuchi, Futoshi Okada, Satoshi Tsunoda, Noriko Kibe, Nobuyuki Shirasawa, Masahito Ikawa, Masaru Okabe, Yoshitaka Ikeda, Junichi Fujii

Biochemical Journal　Vol. 419　No. 1　p. 149-158　2009年4月　研究論文（学術雑誌）

Disruption of the novel gene fad104 causes rapid postnatal death and attenuation of cell proliferation, adhesion, spreading and migration

Makoto Nishizuka, Keishi Kishimoto, Ayumi Kato, Masahito Ikawa, Masaru Okabe, Ryuichiro Sato, Hiroyuki Niida, Makoto Nakanishi, Shigehiro Osada, Masayoshi Imagawa

Experimental Cell Research　Vol. 315　No. 5　p. 809-819　2009年3月10日　研究論文（学術雑誌）

Placenta-specific gene activation and inactivation using integrase-defective lentiviral vectors with the Cre/LoxP system

Yuka Morioka, Ayako Isotani, Robert G. Oshima, Masaru Okabe, Masahito Ikawa

Genesis　Vol. 47　No. 12　p. 793-798　2009年　研究論文（学術雑誌）

Signalling mediated by the endoplasmic reticulum stress transducer OASIS is involved in bone formation

Tomohiko Murakami, Atsushi Saito, Shin Ichiro Hino, Shinichi Kondo, Soshi Kanemoto, Kazuyasu Chihara, Hiroshi Sekiya, Kenji Tsumagari, Kimiko Ochiai, Kazuya Yoshinaga, Masahiro Saitoh, Riko Nishimura, Toshiyuki Yoneda, Ikuyo Kou, Tatsuya Furuichi, Shiro Ikegawa, Masahito Ikawa, Masaru Okabe, Akio Wanaka, Kazunori Imaizumi

Nature Cell Biology　Vol. 11　No. 10　p. 1205-1211　2009年　研究論文（学術雑誌）

Regulation of endoplasmic reticulum stress response by a BBF2H7-mediated Sec23a pathway is essential for chondrogenesis

Atsushi Saito, Shin Ichiro Hino, Tomohiko Murakami, Soshi Kanemoto, Shinichi Kondo, Masahiro Saitoh, Riko Nishimura, Toshiyuki Yoneda, Tatsuya Furuichi, Shiro Ikegawa, Masahito Ikawa, Masaru Okabe, Kazunori Imaizumi

Nature Cell Biology　Vol. 11　No. 10　p. 1197-1204　2009年　研究論文（学術雑誌）

Male germline and embryonic stem cell lines from NOD mice: Efficient derivation of gs cells from a nonpermissive strain for ES cell derivation

Hiroshi Ohta, Yasuhide Ohinata, Masahito Ikawa, Yuka Morioka, Yuko Sakaide, Mitinori Saitou, Osami Kanagawa, Teruhiko Wakayama

Biology of Reproduction　Vol. 81　No. 6　p. 1147-1153　2009年　研究論文（学術雑誌）

Targeted gene modification in mouse ES cells using integrase-defective lentiviral vectors

Yuka Okada, Yuko Ueshin, Hidetoshi Hasuwa, Kazuhiro Takumi, Masaru Okabe, Masahito Ikawa

Genesis　Vol. 47　No. 4　p. 217-223　2009年　研究論文（学術雑誌）

Putative sperm fusion protein IZUMO and the role of N-glycosylation

Naokazu Inoue, Masahito Ikawa, Masaru Okabe

Biochemical and Biophysical Research Communications　Vol. 377　No. 3　p. 910-914　2008年12月19日　研究論文（学術雑誌）

Bis deficiency results in early lethality with metabolic deterioration and involution of spleen and thymus

Dong Ye Youn, Dong Hyoung Lee, Mi Hyun Lim, Jung Sook Yoon, Hee Lim Ji, Eun Jung Seung, Eun Yeum Chung, Whee Park Cheol, Ho Joong Youn, Jae Seon Lee, Seong Beom Lee, Masahito Ikawa, Masaru Okabe, Yoshihide Tsujimoto, Jeong Hwa Lee

American Journal of Physiology - Endocrinology and Metabolism　Vol. 295　No. 6　p. E1349-E1357　2008年12月　研究論文（学術雑誌）

Role of calnexin in the ER quality control and productive folding of CFTR; differential effect of calnexin knockout on wild-type and ΔF508 CFTR

Tsukasa Okiyoneda, Akiko Niibori, Kazutsune Harada, Taijun Kohno, Marek Michalak, Marek Duszyk, Ikuo Wada, Masahito Ikawa, Tsuyoshi Shuto, Mary Ann Suico, Hirofumi Kai

Biochimica et Biophysica Acta - Molecular Cell Research　Vol. 1783　No. 9　p. 1585-1594　2008年9月　研究論文（学術雑誌）

Taurine depletion caused by knocking out the taurine transporter gene leads to cardiomyopathy with cardiac atrophy

Takashi Ito, Yasushi Kimura, Yoriko Uozumi, Mika Takai, Satoko Muraoka, Takahisa Matsuda, Kei Ueki, Minoru Yoshiyama, Masahito Ikawa, Masaru Okabe, Stephen W. Schaffer, Yasushi Fujio, Junichi Azuma

Journal of Molecular and Cellular Cardiology　Vol. 44　No. 5　p. 927-937　2008年5月　研究論文（学術雑誌）

Pluripotency of a single spermatogonial stem cell in mice

Mito Kanatsu-Shinohara, Jiyoung Lee, Kimiko Inoue, Narumi Ogonuki, Hiromi Miki, Shinya Toyokuni, Masahito Ikawa, Tomoyuki Nakamura, Atsuo Ogura, Takashi Shinohara

Biology of Reproduction　Vol. 78　No. 4　p. 681-687　2008年4月　研究論文（学術雑誌）

DNA methylation of retrotransposon genes is regulated by Piwi family members MILI and MIWI2 in murine fetal testes

Satomi Kuramochi-Miyagawa, Toshiaki Watanabe, Kengo Gotoh, Yasushi Totoki, Atsushi Toyoda, Masahito Ikawa, Noriko Asada, Kanako Kojima, Yuka Yamaguchi, Takashi W. Ijiri, Kenichiro Hata, En Li, Yoichi Matsuda, Tohru Kimura, Masaru Okabe, Yoshiyuki Sakaki, Hiroyuki Sasaki, Toru Nakano

Genes and Development　Vol. 22　No. 7　p. 908-917　2008年4月　研究論文（学術雑誌）

Neuroaxonal dystrophy caused by group VIA phospholipase A<inf>2</inf> deficiency in mice: A model of human neurodegenerative disease

Koei Shinzawa, Hisae Sumi, Masahito Ikawa, Yosuke Matsuoka, Masaru Okabe, Saburo Sakoda, Yoshihide Tsujimoto

Journal of Neuroscience　Vol. 28　No. 9　p. 2212-2220　2008年2月27日　研究論文（学術雑誌）

Ghrelin deficiency does not influence feeding performance

Takahiro Sato, Mamoru Kurokawa, Yoshiki Nakashima, Takanori Ida, Tomoko Takahashi, Yoshihiko Fukue, Masahito Ikawa, Masaru Okabe, Kenji Kangawa, Masayasu Kojima

Regulatory Peptides　Vol. 145　No. 1-3　p. 7-11　2008年1月10日

Disruption of miR-200b leads to female infertility

Hidetoshi Hasuwa, Masahito Ikawa, Masaru Okabe

BIOLOGY OF REPRODUCTION　p. 213-213　2008年

Cd52, known as a major maturation-associated sperm membrane antigen secreted from the epididymis, is not required for fertilization in the mouse

Ryo Yamaguchi, Kazuo Yamagata, Hidetoshi Hasuwa, Emiko Inano, Masahito Ikawa, Masaru Okabe

Genes to Cells　Vol. 13　No. 8　p. 851-861　2008年　研究論文（学術雑誌）

Mechanisms of sperm-egg interactions emerging from gene-manipulated animals

Masahito Ikawa, Naokazu Inoue, Masaru Okabe

International Journal of Developmental Biology　Vol. 52　No. 5-6　p. 657-664　2008年

Innate versus learned odour processing in the mouse olfactory bulb

Ko Kobayakawa, Reiko Kobayakawa, Hideyuki Matsumoto, Yuichiro Oka, Takeshi Imai, Masahito Ikawa, Masaru Okabe, Toshio Ikeda, Shigeyoshi Itohara, Takefumi Kikusui, Kensaku Mori, Hitoshi Sakano

Nature　Vol. 450　No. 7169　p. 503-508　2007年11月21日　研究論文（学術雑誌）

Efficient derivation of embryonic stem cells by inhibition of glycogen synthase kinase-3

Hiroki Umehara, Tohru Kimura, Satoshi Ohtsuka, Toshinobu Nakamura, Kenji Kitajima, Masahito Ikawa, Masaru Okabe, Hitoshi Niwa, Toru Nakano

Stem Cells　Vol. 25　No. 11　p. 2705-2711　2007年11月　研究論文（学術雑誌）

PGAP1 knock-out mice show otocephaly and male infertility

Yasutaka Ueda, Ryo Yamaguchi, Masahito Ikawa, Masaru Okabe, Eiichi Morii, Yusuke Maeda, Taroh Kinoshita

Journal of Biological Chemistry　Vol. 282　No. 42　p. 30373-30380　2007年10月19日　研究論文（学術雑誌）

Hypertension and dysregulated proinflammatory cytokine production in receptor activity-modifying protein 1-deficient mice

Kazutake Tsujikawa, Katsutoshi Yayama, Tamon Hayashi, Hiroaki Matsushita, Taijiro Yamaguchi, Tomomi Shigeno, Yusuke Ogitani, Megumi Hirayama, Tetsuya Kato, So Ichiro Fukada, Shingo Takatori, Hiromu Kawasaki, Hiroshi Okamoto, Masahito Ikawa, Masaru Okabe, Hiroshi Yamamoto

Proceedings of the National Academy of Sciences of the United States of America　Vol. 104　No. 42　p. 16702-16707　2007年10月16日　研究論文（学術雑誌）

Lats2 is an essential mitotic regulator required for the coordination of cell division

Norikazu Yabuta, Nobuhiro Okada, Akihiko Ito, Toshiya Hosomi, Souichi Nishihara, Yuya Sasayama, Azumi Fujimori, Daisuke Okuzaki, Hanjun Zhao, Masahito Ikawa, Masaru Okabe, Hiroshi Nojima

Journal of Biological Chemistry　Vol. 282　No. 26　p. 19259-19271　2007年6月29日　研究論文（学術雑誌）

Mcp4, a meiotic coiled-coil protein, plays a role in F-actin positioning during Schizosaccharomyces pombe meiosis

Ayami Ohtaka, Daisuke Okuzaki, Takamune T. Saito, Hiroshi Nojima

EUKARYOTIC CELL　Vol. 6　No. 6　p. 971-983　2007年6月　研究論文（学術雑誌）

Antitumor NK activation induced by the Toll-like receptor 3-TICAM-1 (TRIF) pathway in myeloid dendritic cells

Takashi Akazawa, Takashi Ebihara, Manabu Okuno, Yu Okuda, Masashi Shingai, Kunio Tsujimura, Toshitada Takahashi, Masahito Ikawa, Masaru Okabe, Norimitsu Inoue, Miki Okamoto-Tanaka, Hiroyoshi Ishizaki, Jun Miyoshi, Misako Matsumoto, Tsukasa Seya

Proceedings of the National Academy of Sciences of the United States of America　Vol. 104　No. 1　p. 252-257　2007年1月2日　研究論文（学術雑誌）

Sperm-egg interaction and gene manipulated animals.

Naokazu Inoue, Ryo Yamaguchi, Masahito Ikawa, Masaru Okabe

Society of Reproduction and Fertility supplement　Vol. 65　p. 363-371　2007年

PGC7/Stella protects against DNA demethylation in early embryogenesis

Toshinobu Nakamura, Yoshikazu Arai, Hiroki Umehara, Masaaki Masuhara, Tohru Kimura, Hisaaki Taniguchi, Toshihiro Sekimoto, Masahito Ikawa, Yoshihiro Yoneda, Masaru Okabe, Satoshi Tanaka, Kunio Shiota, Toru Nakano

Nature Cell Biology　Vol. 9　No. 1　p. 64-71　2007年1月　研究論文（学術雑誌）

Aberrant distribution of ADAM3 in sperm from both angiotensin-converting enzyme (Ace)- and calmegin (Clgn)-deficient mice

Ryo Yamaguchi, Kazuo Yamagata, Masahito Ikawa, Stuart B. Moss, Masaru Okabe

Biology of Reproduction　Vol. 75　No. 5　p. 760-766　2006年11月　研究論文（学術雑誌）

The testes-specific bZip type transcription factor Tisp40 plays a role in ER stress responses and chromatin packaging during spermiogenesis

Ippei Nagamori, Kentaro Yomogida, Masahito Ikawa, Masaru Okabe, Norikazu Yabuta, Hiroshi Nojima

Genes to Cells　Vol. 11　No. 10　p. 1161-1171　2006年10月　研究論文（学術雑誌）

Rapid generation of knockdown transgenic mice by silencing lentiviral vectors

Oded Singer, Gustavo Tiscornia, Masahito Ikawa, Inder M. Verma

Nature Protocols　Vol. 1　No. 1　p. 286-292　2006年6月　研究論文（学術雑誌）

Deletion of SERP1/RAMP4, a component of the endoplasmic reticulum (ER) translocation sites, leads to ER stress

Osamu Hori, Mayuki Miyazaki, Takashi Tamatani, Kentaro Ozawa, Katsura Takano, Masaru Okabe, Masahito Ikawa, Enno Hartmann, Petra Mai, David M. Stern, Yasuko Kitao, Satoshi Ogawa

Molecular and Cellular Biology　Vol. 26　No. 11　p. 4257-4267　2006年6月　研究論文（学術雑誌）

Plexin-A1 and its interaction with DAP12 in immune responses and bone homeostasis

Noriko Takegahara, Hyota Takamatsu, Toshihiko Toyofuku, Tohru Tsujimura, Tatsusada Okuno, Kazunori Yukawa, Masayuki Mizui, Midori Yamamoto, Durbaka V.R. Prasad, Kazuhiro Suzuki, Masaru Ishii, Kenta Terai, Masayuki Moriya, Yuji Nakatsuji, Saburo Sakoda, Shintaro Sato, Shizuo Akira, Kiyoshi Takeda, Masanori Inui, Toshiyuki Takai, Masahito Ikawa, Masaru Okabe, Atsushi Kumanogoh, Hitoshi Kikutani

Nature Cell Biology　Vol. 8　No. 6　p. 615-622　2006年6月　研究論文（学術雑誌）

Choroidal neovascularization in transgenic mice expressing prokineticin 1: An animal model for age-related macular degeneration

Nobushige Tanaka, Masahito Ikawa, Nathan L. Mata, Inder M. Verma

Molecular Therapy　Vol. 13　No. 3　p. 609-616　2006年3月　研究論文（学術雑誌）

Comparison of gene expression in male and female mouse blastocysts revealed imprinting of the X-linked gene, Rhox5/Pem, at preimplantation stages

Shin Kobayashi, Ayako Isotani, Nathan Mise, Masamichi Yamamoto, Yoshitaka Fujihara, Kazuhiro Kaseda, Tomoko Nakanishi, Masahito Ikawa, Hiroshi Hamada, Kuniya Abe, Masaru Okabe

Current Biology　Vol. 16　No. 2　p. 166-172　2006年1月24日　研究論文（学術雑誌）

Analysis of mice that show abnormal expression of neuroglycan C, a central nervous system-specific transmembrane proteoglycan

Sachiko Aono, Yoshiyuki Kuroda, Fumiko Matsui, Yoshihito Tokita, Keiko Nakanishi, Michiru Ida, Masahito Ikawa, Masaru Okabe, Katsuhiko Ono, Atsuhiko Oohira

NEUROSCIENCE RESEARCH　Vol. 55　p. S186-S186　2006年

RECS1 deficiency in mice induces susceptibility to cystic medial degeneration

Hanjun Zhao, Akihiko Ito, Shinya H. Kimura, Norikazu Yabuta, Naohiko Sakai, Masahito Ikawa, Masaru Okabe, Yuji Matsuzawa, Shizuya Yamashita, Hiroshi Nojima

Genes and Genetic Systems　Vol. 81　No. 1　p. 41-50　2006年　研究論文（学術雑誌）

Distinct roles of IκB proteins in regulating constitutive NF-κB activity

Vinay Tergaonkar, Ricardo G. Correa, Masahito Ikawa, Inder M. Verma

Nature Cell Biology　Vol. 7　No. 9　p. 921-923　2005年9月　研究論文（学術雑誌）

Impaired urea accumulation in the inner medulla of mice lacking the urea transporter UT-A2

Shinichi Uchida, Eisei Sohara, Tatemitsu Rai, Masahito Ikawa, Masaru Okabe, Sei Sasaki

Molecular and Cellular Biology　Vol. 25　No. 16　p. 7357-7363　2005年8月　研究論文（学術雑誌）

Progressive adipocyte hypertrophy in aquaporin-7-deficient mice: Adipocyte glycerol permeability as a novel regulator of fat accumulation

Mariko Hara-Chikuma, Eisei Sohara, Tatemitsu Rai, Masahito Ikawa, Masaru Okabe, Sei Sasaki, Shinichi Uchida, A. S. Verkman

Journal of Biological Chemistry　Vol. 280　No. 16　p. 15493-15496　2005年4月　研究論文（学術雑誌）

Neuromedin U has a novel anorexigenic effect independent of the leptin signaling pathway

Reiko Hanada, Hitoshi Teranishi, James Todd Pearson, Mamoru Kurokawa, Hiroshi Hosoda, Nobuhiro Fukushima, Yoshihiko Fukue, Ryota Serino, Hiroaki Fujihara, Yoichi Ueta, Masahito Ikawa, Masaru Okabe, Noboru Murakami, Mikiyasu Shirai, Hironobu Yoshimatsu, Kenji Kangawa, Masayasu Kojima

Nature Medicine　Vol. 10　No. 10　p. 1067-1073　2004年10月　研究論文（学術雑誌）

Selective passage through the uterotubal junction of sperm from a mixed population produced by chimeras of calmegin-knockout and wild-type male mice

Tomoko Nakanishi, Ayako Isotani, Ryo Yamaguchi, Masahito Ikawa, Tadashi Baba, Susan S. Suarez, Masaru Okabe

Biology of Reproduction　Vol. 71　No. 3　p. 959-965　2004年9月　研究論文（学術雑誌）

Lineage-specific cell disruption in living mice by Cre-mediated expression of diphtheria toxin A chain

Hiroyuki Matsumura, Hidetoshi Hasuwa, Naokazu Inoue, Masahito Ikawa, Masaru Okabe

Biochemical and Biophysical Research Communications　Vol. 321　No. 2　p. 275-279　2004年8月20日　研究論文（学術雑誌）

The LIM homeobox gene, L3/Lhx8, is necessary for proper development of basal forebrain cholinergic neurons

Tetsuji Mori, Zhang Yuxing, Hiromi Takaki, Mayumi Takeuchi, Ken Iseki, Seita Hagino, Jun Ichi Kitanaka, Motohiko Takemura, Hidemi Misawa, Masahito Ikawa, Masaru Okabe, Akio Wanaka

European Journal of Neuroscience　Vol. 19　No. 12　p. 3129-3141　2004年6月　研究論文（学術雑誌）

Identification of the XPG Region That Causes the Onset of Cockayne Syndrome by Using Xpg Mutant Mice Generated by the cDNA-Mediated Knock-In Method

Naoko Shiomi, Seiji Kito, Masaki Oyama, Tsukasa Matsunaga, Yoshi Nobu Harada, Masahito Ikawa, Masaru Okabe, Tadahiro Shiomi

Molecular and Cellular Biology　Vol. 24　No. 9　p. 3712-3719　2004年5月　研究論文（学術雑誌）

Mili, a mammalian member of piwi family gene, is essential for spermatogenesis

Satomi Kuramochi-Miyagawa, Tohru Kimura, Takashi W. Ijiri, Taku Isobe, Noriko Asada, Yukiko Fujita, Masahito Ikawa, Naomi Iwai, Masaru Okabe, Wei Deng, Haifan Lin, Yoichi Matsuda, Toru Nakano

Development　Vol. 131　No. 4　p. 839-849　2004年2月　研究論文（学術雑誌）

IκB Kinase-Independent IκBα Degradation Pathway: Functional NF-κB Activity and Implications for Cancer Therapy

Vinay Tergaonkar, Virginie Bottero, Masahito Ikawa, Qiutang Li, Inder M. Verma

Molecular and Cellular Biology　Vol. 23　No. 22　p. 8070-8083　2003年11月　研究論文（学術雑誌）

Generation of transgenic mice using lentiviral vectors: A novel preclinical assessment of lectiviral vectors for gene therapy

Masahito Ikawa, Nobushige Tanaka, Winston W.Y. Kao, Inder M. Verma

Molecular Therapy　Vol. 8　No. 4　p. 666-673　2003年10月　研究論文（学術雑誌）

Disruption of mouse CD46 causes an accelerated spontaneous acrosome reaction in sperm

Naokazu Inoue, Masahito Ikawa, Tomoko Nakanishi, Misako Matsumoto, Midori Nomura, Tsukasa Seya, Masaru Okabe

Molecular and Cellular Biology　Vol. 23　No. 7　p. 2614-2622　2003年4月　研究論文（学術雑誌）

Mouse germ cell-less as an essential component for nuclear integrity

Tohru Kimura, Chizuru Ito, Shoko Watanabe, Tohru Takahashi, Masahito Ikawa, Kentaro Yomogida, Yukiko Fujita, Megumi Ikeuchi, Noriko Asada, Kiyomi Matsumiya, Akihiko Okuyama, Masaru Okabe, Kiyotaka Toshimori, Toru Nakano

Molecular and Cellular Biology　Vol. 23　No. 4　p. 1304-1315　2003年2月　研究論文（学術雑誌）

Mouse sperm lacking cell surface hyaluronidase PH-20 can pass through the layer of cumulus cells and fertilize the egg.

Daichi Baba, Shin ichi Kashiwabara, Arata Honda, Kazuo Yamagata, Qing Wu, Masahito Ikawa, Masaru Okabe, Tadashi Baba

The Journal of biological chemistry　Vol. 277　No. 33　p. 30310-30314　2002年8月16日　研究論文（学術雑誌）

Fish analysis of 142 EGFP transgene integration sites into the mouse genome

Tomoko Nakanishi, Asato Kuroiwa, Shuichi Yamada, Ayako Isotani, Atsuko Yamashita, Ai Tairaka, Tamon Hayashi, Tatsuya Takagi, Masahito Ikawa, Yoichi Matsuda, Masaru Okabe

Genomics　Vol. 80　No. 6　p. 564-574　2002年　研究論文（学術雑誌）

Sperm from the calmegin-deficient mouse have normal abilities for binding and fusion to the egg plasma membrane

Kazuo Yamagata, Tomoko Nakanishi, Masahito Ikawa, Ryou Yamaguchi, Stuart B. Moss, Masaru Okabe

Developmental Biology　Vol. 250　No. 2　p. 348-357　2002年　研究論文（学術雑誌）

Calmegin is required for fertilin α/β heterodimerization and sperm fertility

Masahito Ikawa, Tomoko Nakanishi, Shuichi Yamada, Ikuo Wada, Katsuya Kominami, Hiromitsu Tanaka, Masami Nozaki, Yoshitake Nishimune, Masaru Okabe

Developmental Biology　Vol. 240　No. 1　p. 254-261　2001年12月1日　研究論文（学術雑誌）

Alkalinization of acrosome measured by GFP as a pH indicator and its relation to sperm capacitation

Tomoko Nakanishi, Masahito Ikawa, Shuichi Yamada, Kiyotaka Toshimori, Masaru Okabe

Developmental Biology　Vol. 237　No. 1　p. 222-231　2001年9月1日　研究論文（学術雑誌）

Efficient chromosomal transposition of a Tc1/mariner-like transposon Sleeping Beauty in mice

Kyoji Horie, Asato Kuroiwa, Masahito Ikawa, Masaru Okabe, Gen Kondoh, Yoichi Matsuda, Junji Takeda

Proceedings of the National Academy of Sciences of the United States of America　Vol. 98　No. 16　p. 9191-9196　2001年7月31日　研究論文（学術雑誌）

A synthetic DAF (CD55) gene based on optimal codon usage for transgenic animals

Shuji Miyagawa, Mako Yamada, Katsuyoshi Matsunami, Yukie Koresawa, Masahito Ikawa, Masaru Okabe, Ryota Shirakura

Journal of Biochemistry　Vol. 129　No. 5　p. 795-801　2001年5月　研究論文（学術雑誌）

Expression of the endoplasmic reticulum molecular chaperone (ORP150) rescues hippocampal neurons from glutamate toxicity

Yasuko Kitao, Kentaro Ozawa, Mayuki Miyazaki, Michio Tamatani, Tomohiro Kobayashi, Hideki Yanagi, Masaru Okabe, Masahito Ikawa, Tetsumori Yamashima, David M. Stern, Osamu Hori, Satoshi Ogawa

Journal of Clinical Investigation　Vol. 108　No. 10　p. 1439-1450　2001年　研究論文（学術雑誌）

Cyclin G1 is involved in G2/M arrest in response to DNA damage and in growth control after damage recovery

Shinya H. Kimura, Masahito Ikawa, Akihiko Ito, Masaru Okabe, Hiroshi Nojima

Oncogene　Vol. 20　No. 25　p. 3290-3300　2001年　研究論文（学術雑誌）

A codon exchange DAF is a powerful material for xenografting

M. Yamada, S. Miyagawa, K. Matsunami, Y. Koresawa, T. Kurihara, M. Ikawa, M. Okabe, R. Shirakura

Transplantation Proceedings　Vol. 33　No. 1-2　p. 744-745　2001年　研究論文（国際会議プロシーディングス）

Erratum: Homeobox gene Hex is essential for onset of mouse embryonic liver development and differentiation of the monocyte lineage (Biochemical and Biophysical Research Communication (2000) 276:3 (1155-1161))

V. W. Keng, H. Yagi, M. Ikawa, T. Nagano, Z. Myint, K. Yamada, T. Tanaka, A. Sato, I. Muramatsu, M. Okabe, M. Sato, T. Noguchi

Biochemical and Biophysical Research Communications　Vol. 279　No. 2　2000年12月20日　研究論文（学術雑誌）

Green fluorescent protein-transgenic mice: Immune functions and their application to studies of lymphocyte development

Naoto Kawakami, Naoki Sakane, Fumiko Nishizawa, Mutsumi Iwao, So Ichiro Fukada, Kazutake Tsujikawa, Yasuhiro Kohama, Masahito Ikawa, Masaru Okabe, Hiroshi Yamamoto

Immunology Letters　Vol. 70　No. 3　p. 165-171　2000年12月1日　研究論文（学術雑誌）

Homeobox gene Hex is essential for onset of mouse embryonic liver development and differentiation of the monocyte lineage

Vincent W. Keng, Hideshi Yagi, Masahito Ikawa, Takashi Nagano, Zaw Myint, Kazuya Yamada, Takashi Tanaka, Ayuko Sato, Ikunobu Muramatsu, Masaru Okabe, Makoto Sato, Tamio Noguchi

Biochemical and Biophysical Research Communications　Vol. 276　No. 3　p. 1155-1161　2000年10月5日　研究論文（学術雑誌）

17.Creリコンビナーゼを介した組み換えによりEGFPを発現するようになるレポーターマウスの開発

伊川 正人, 林 多門, 中西 友子, 山下 敦子, 三輪 岳志, 岡部 勝

日本疾患モデル学会記録　Vol. 16　p. 24-24　2000年

The class IV semaphorin CD100 plays nonredundant roles in the immune system: Defective B and T cell activation in CD100-deficient mice

Wei Shi, Atsushi Kumanogoh, Chie Watanabe, Junji Uchida, Xiaosong Wang, Teruhito Yasui, Kazunori Yukawa, Masahito Ikawa, Masaru Okabe, Jane R. Parnes, Kanji Yoshida, Hitoshi Kikutani

Immunity　Vol. 13　No. 5　p. 633-642　2000年　研究論文（学術雑誌）

Mice with markedly reduced PACAP (PAC<inf>1</inf>) receptor expression by targeted deletion of the signal peptide

Hitoshi Hashimoto, Norihito Shintani, Akiko Nishino, Masaru Okabe, Masahito Ikawa, Shogo Matsuyama, Kyoko Itoh, Kyohei Yamamoto, Shuhei Tomimoto, Takashi Fujita, Nami Hagihara, Wakaba Mori, Yutaka Koyama, Toshio Matsuda, Shigekazu Nagata, Akemichi Baba

Journal of Neurochemistry　Vol. 75　No. 5　p. 1810-1817　2000年　研究論文（学術雑誌）

A new Cre recombinase gene based on optimal codon usage in mammals: A powerful material for organ-specific gene targeting

Y. Koresawa, S. Miyagawa, M. Ikawa, K. Matsunami, M. Yamada, M. Okabe, R. Shirakura

Transplantation Proceedings　Vol. 32　No. 7　p. 2516-2517　2000年　研究論文（学術雑誌）

Synthesis of a new Cre recombinase gene based on optimal codon usage for mammalian systems

Yukie Koresawa, Shuji Miyagawa, Masahito Ikawa, Katsuyoshi Matsunami, Mako Yamada, Ryota Shirakura, Masaru Okabe

Journal of Biochemistry　Vol. 127　No. 3　p. 367-372　2000年　研究論文（学術雑誌）

Roles of integrins and CD44 on the adhesion and migration of fetal liver cells to the fetal thymus

Naoto Kawakami, Fumiko Nishizawa, Naoki Sakane, Mutsumi Iwao, Kazutake Tsujikawa, Masahito Ikawa, Masaru Okabe, Hiroshi Yamamoto

Journal of Immunology　Vol. 163　No. 6　p. 3211-3216　1999年9月15日　研究論文（学術雑誌）

Migration of exogenous immature hematopoietic cells into adult mouse brain parenchyma under GFP-expressing bone marrow chimera

Kenji Ono, Takemasa Takii, Kikuo Onozaki, Masahito Ikawa, Masaru Okabe, Makoto Sawada

Biochemical and Biophysical Research Communications　Vol. 262　No. 3　p. 610-614　1999年9月7日　研究論文（学術雑誌）

Mutation in ankyrin repeats of the mouse Notch2 gene induces early embryonic lethality

Yoshio Hamada, Yuzo Kadokawa, Masaru Okabe, Masahito Ikawa, John R. Coleman, Yoshihide Tsujimoto

Development　Vol. 126　No. 15　p. 3415-3424　1999年8月　研究論文（学術雑誌）

Real-time observation of acrosomal dispersal from mouse sperm using GFP as a marker protein

Tomoko Nakanishi, Masahito Ikawa, Shuichi Yamada, Martti Parvinen, Tadashi Baba, Yoshitake Nishimune, Masaru Okabe

FEBS Letters　Vol. 449　No. 2-3　p. 277-283　1999年4月　研究論文（学術雑誌）

Postnatal growth failure, short life span, and early onset of cellular senescence and subsequent immortalization in mice lacking the xeroderma pigmentosum group G gene

Yoshi Nobu Harada, Naoko Shiomi, Manabu Koike, Masahito Ikawa, Masaru Okabe, Seiichi Hirota, Yukihiko Kitamura, Masanobu Kitagawa, Tsukasa Matsunaga, Osamu Nikaido, Tadahiro Shiomi

Molecular and Cellular Biology　Vol. 19　No. 3　p. 2366-2372　1999年3月　研究論文（学術雑誌）

25.Green Fluorescent Protein (GFP) を用いた雌雄胚の判別

中西 友子, 松田 洋一, 黒岩 麻里, 伊川 正人, 山田 秀一, 三輪 岳志, 岡部 勝

日本疾患モデル学会記録　Vol. 15　p. 39-39　1999年

24.Calmegin (精巣特異的シャペロン) ノックアウトマウス精子受精能の解析

伊川 正人, 山田 秀一, 中西 友子, 馬場 忠, 西宗 義武, 岡部 勝

日本疾患モデル学会記録　Vol. 15　p. 38-38　1999年

Green fluorescent protein (GFP) as a marker for cell viability after UV irradiation

C. Baumstark-Khan, M. Palm, J. Wehner, M. Okabe, M. Ikawa, G. Horneck

Journal of Fluorescence　Vol. 9　No. 1　p. 37-43　1999年　研究論文（学術雑誌）

The putative chaperone calmegin and sperm fertility.

M Okabe, M Ikawa, S Yamada, T Nakanishi, T Baba, Y Nishimune

MALE GAMETE: FROM BASIC SCIENCE TO CLINICAL APPLICATIONS　p. 47-54　1999年　研究論文（国際会議プロシーディングス）

Efficient selection of transgenic mouse embryos using EGFP as a marker gene

Minoru Kato, Keitaro Yamanouchi, Masahito Ikawa, Masaru Okabe, Kunihiko Naito, Hideaki Tojo

Molecular Reproduction and Development　Vol. 54　No. 1　p. 43-48　1999年　研究論文（学術雑誌）

Glowing podocytes in living mouse: Transgenic mouse carrying a podocyte- specific promoter

Enyu Imai, Yoshitaka Akagi, Yoshitaka Isaka, Masahito Ikawa, Masaru Takenaka, Masatsugu Hori, Masaru Okabe

Experimental Nephrology　Vol. 7　No. 1　p. 63-66　1999年　研究論文（国際会議プロシーディングス）

Studies on the Mechanism of Sperm Prodution

Tanaka H, Okabe M, Ikawa M, Tsuchida J, Yoshimura Y, Yomogida Y, Nishimune Y

Testicular Function: From Gene Expression to Genetic Manipulation.　Vol. 235-254　1998年10月

Generating green fluorescent mice by germline transmission of green fluorescent ES cells

Anna Katerina Hadjantonakis, Marina Gertsenstein, Masahito Ikawa, Masaru Okabe, Andras Nagy

Mechanisms of Development　Vol. 76　No. 1-2　p. 79-90　1998年8月　研究論文（学術雑誌）

'Green mice' and their potential usage in biological research

Masahito Ikawa, Shuichi Yamada, Tomoko Nakanishi, Masaru Okabe

FEBS Letters　Vol. 430　No. 1-2　p. 83-87　1998年6月23日　研究論文（国際会議プロシーディングス）

Prevention of hyperacute rejection by phosphatidylinositol-anchored mini-complement receptor type 1

Shoki Mikata, Shuji Miyagawa, Masao Yoshitatsu, Masato Ikawa, Masaru Okabe, Hikaru Matsuda, Ryota Shirakura

Transplant Immunology　Vol. 6　No. 2　p. 107-110　1998年6月　研究論文（学術雑誌）

Gametogenesis '98: Male infertility and the genetics of spermatogenesis

Masaru Okabe, Masahito Ikawa, John Ashkenas

American Journal of Human Genetics　Vol. 62　No. 6　p. 1274-1281　1998年6月　研究論文（学術雑誌）

Defective stratum corneum and early neonatal death in mice lacking the gene for transglutaminase 1 (keratinocyte transglutaminase)

Masato Matsuki, Fumiyoshi Yamashita, Akemi Ishida-Yamamoto, Keiko Yamada, Chikako Kinoshita, Shinji Fushiki, Eiichiro Ueda, Yohichi Morishima, Kohichi Tabata, Hirokazu Yasuno, Mitsuru Hashida, Hajime Iizuka, Masahito Ikawa, Masaru Okabe, Gen Kondoh, Taroh Kinoshita, Junji Takeda, Kiyofumi Yamanishi

Proceedings of the National Academy of Sciences of the United States of America　Vol. 95　No. 3　p. 1044-1049　1998年2月3日　研究論文（学術雑誌）

18.Green fluorescent proteinを用いた精子機能の解析

中西 友子, 伊川 正人, 山田 秀一, 馬場 忠, 西宗 義武, 岡部 勝

日本疾患モデル学会記録　Vol. 14　p. 40-40　1998年

The putative chaperone calmegin is required for sperm fertility

Masahito Ikawa, Ikuo Wada, Katsuya Kominami, Daisuke Watanabe, Kiyotaka Toshimori, Yoshitake Nishimune, Masaru Okabe

Zygote　Vol. 6　No. 1 SUPPL.　1998年　研究論文（学術雑誌）

Green fluorescent protein and its usage in reproductive biology

Masaru Okabe, Masahito Ikawa, Tomoko Nakanishi, Shuichi Yamada, Tadashi Baba, Yoshitake Nishimune

Zygote　Vol. 6　No. 1 SUPPL.　1998年　研究論文（学術雑誌）

Induction of EAE by Th1-type, GFP⁺ MOG-specific T cells in C57BL/6 mice

Mamoru Yura, Masashi Serada, Ichiro Takahashi, Hiroshi Kiyono, Takehiro Koshio, Keiji Nakagami, Masahito Ikawa, Masaru Okabe

Japanese Journal of Clinical Immunology　Vol. 21　p. 125-134　1998年　研究論文（学術雑誌）

The putative chaperone calmegin is required for sperm fertility

M. Ikawa, I. Wada, K. Kominami, D. Watanabe, K. Toshimori, Y. Nishimune, M. Okabe

Journal of Urology　Vol. 160　No. 2　1998年　研究論文（学術雑誌）

Non-invasive sexing of preimplantation stage mammalian embryos [2]

A. K. Hadjantonakis, M. Gertsenstein, M. Ikawa, M. Okabe, A. Nagy

Nature Genetics　Vol. 19　No. 3　p. 220-222　1998年

1 Green Fluorescent Protein (GFP) as a Vital Marker in Mammals

Masahito Ikawa, Shuichi Yamada, Tomoko Nakanishi, Masaru Okabe

Current Topics in Developmental Biology　Vol. 44　No. C　p. 1-6　1998年1月1日　研究論文（学術雑誌）

Cloning and characterization of the human Calmegin gene encoding putative testis-specific chaperone

Hiromitsu Tanaka, Masahito Ikawa, Junji Tsuchida, Masami Nozaki, Mikio Suzuki, Tsutomu Fujiwara, Masaru Okabe, Yoshitake Nishimune

Gene　Vol. 204　No. 1-2　p. 159-163　1997年12月19日　研究論文（学術雑誌）

Tissue-specific knockout of the mouse Pig-a gene reveals important roles for GPI-anchored proteins in skin development

Masahito Tarutani, Satoshi Itami, Masaru Okabe, Masahito Ikawa, Tadashi Tezuka, Kunihiko Yoshikawa, Taroh Kinoshita, Junji Takeda

Proceedings of the National Academy of Sciences of the United States of America　Vol. 94　No. 14　p. 7400-7405　1997年7月8日　研究論文（学術雑誌）

'Green mice' as a source of ubiquitous green cells

Masaru Okabe, Masahito Ikawa, Katsuya Kominami, Tomoko Nakanishi, Yoshitake Nishimune

FEBS Letters　Vol. 407　No. 3　p. 313-319　1997年5月5日　研究論文（学術雑誌）

The regulation of membrane cofactor protein (CD46) expression by the 3' untranslated region in transgenic mice

Shuji Miyagawa, Shoki Mikata, Hironori Tanaka, Masahito Ikawa, Katsuya Kominami, Tsukasa Seya, Yoshitake Nishimune, Ryota Shirakura, Masaru Okabe

Biochemical and Biophysical Research Communications　Vol. 233　No. 3　p. 829-833　1997年4月　研究論文（学術雑誌）

20.ヒトcalmegin遺伝子のクローニングと精巣における特異的発現

田中 宏光, 伊川 正人, 土田 順司, 野崎 正美, 岡部 勝, 西宗 義武

日本疾患モデル学会記録　Vol. 13　p. 105-105　1997年

Spermatogenesis: Molecular biological approaches

Y Nishimune, M Okabe, H Tanaka, J Tsuchida, M Ikawa

CURRENT ADVANCES IN ANDROLOGY　Vol. 111-117　p. 111-117　1997年　研究論文（国際会議プロシーディングス）

Transcriptional activation of a hybrid promoter composed of cytomegalovirus enhancer and β-actin/β-globin gene in glomerular epithelial cells in vivo

Yoshitaka Akagi, Yoshitaka Isaka, Akiko Akagi, Masahito Ikawa, Masaru Takenaka, Toshiki Moriyama, Atsushi Yamauchi, Masaru Horio, Naohiko Ueda, Masaru Okabe, Enyu Imai

Kidney International　Vol. 51　No. 4　p. 1265-1269　1997年　研究論文（学術雑誌）

The regulation of membrane cofactor protein (CD46) expression in transgenic mice: The importance of the first 125 bp of the 3' untranslated region

S. Miyagawa, M. Ikawa, K. Kominami, H. Tanaka, S. Mikata, H. Matsuda, T. Seya, R. Shirakura, M. Okabe

Transplantation Proceedings　Vol. 29　No. 1-2　p. 941-942　1997年　研究論文（国際会議プロシーディングス）

Glycosylphosphatidylinositol-anchor-deficient mice: Implications for clonal dominance of mutant cells in paroxysmal nocturnal hemoglobinuria

Kazuyoshi Kawagoe, Daisuke Kitamura, Masaru Okabe, Ichiro Taniuchi, Masahito Ikawa, Takeshi Watanabe, Taroh Kinoshita, Junji Takeda

Blood　Vol. 87　No. 9　p. 3600-3606　1996年5月1日　研究論文（学術雑誌）

Induction of Orchitis by Intra-seminiferous Tubular Injection of Lipofectamine

Kominami K., Okabe M., Ikawa M., Nishimune Y.

Proceedings of Annual Meeting of JSIR　Vol. 10　p. 31-32　1996年

Difference of expression levels between gene technological product ΔCYT- MCP(CD46) and intact MCP(CD46) in transgenic mice

Miyagawa S, Ikawa M, Kominami K, Yoshimura Y, Tanaka H, Mikata S, Shirakura R, Matsuda H, Yanagi Y, Seya T, Okabe M

Transplantation Proceedings　Vol. 28　No. 2　p. 585-586　1996年　研究論文（国際会議プロシーディングス）

In vitro and in vivo studies to prevent hyperacute rejection

S. Miyagawa, M. Mikata, H. Matsuda, M. Ikawa, M. Okabe, S. Nagasawa, M. Matsumoto, T. Seya, R. Shirakura

Transplantation Proceedings　Vol. 28　No. 2　p. 1031-1033　1996年　研究論文（国際会議プロシーディングス）

A rapid and non-invasive selection of transgenic embryos before implantation using green fluorescent protein (GFP)

Masahito Ikawa, Katsuya Kominami, Yasuhide Yoshimura, Keiichi Tanaka, Yoshitake Nishimune, Masaru Okabe

FEBS Letters　Vol. 375　No. 1-2　p. 125-128　1995年11月13日　研究論文（学術雑誌）

Green fluorescent protein as a marker in transgenic mice

Masahito Ikawa, Katsuya Kominami, Yasuhide Yoshimura, Keiichi Tanaka, Yoshitake Nishimune, Masaru Okabe

Development, Growth &amp; Differentiation　Vol. 37　No. 4　p. 455-459　1995年8月　研究論文（学術雑誌）

Limited localization of mouse complement regulatory protein Crry/P65 on mouse sperm

Ikawa M., Kominami K., Seya T., Okabe M.

Proceedings of Annual Meeting of JSIR　Vol. 9　p. 23-24　1995年

Improvement of Fusing Ability of Human Sperm to Zona-Free Hamster Eggs by Conditioned Media

Masahito Ikawa, Masahito Ikawa, Xing Ying, Keiichi Tanaka, Kazutomo Ohashi, Kazutomo Ohashi, Fumitaka Saji, Masahito Ikawa, Masaru Okabe

Biological and Pharmaceutical Bulletin　Vol. 18　No. 1　p. 5-8　1995年　研究論文（学術雑誌）

TRANSGENIC MICE THAT EXPRESS HUMAN CD4 ON SPERMATID

Okabe M., Ikawa M., Noguchi T., Nishimune Y.

Proceedings of Annual Meeting of JSIR　Vol. 8　p. 40-43　1994年

Degeneration of skeletal and cardiac muscles in c-myb transgenic mice (共著)

Furuta Y, Aizawa S, Suda Y, Ikawa Y, Nakagoshi H, Nishina Y, Ishii S

Transgenic Research　Vol. 2　No. 4　p. 199-207　1993年7月　研究論文（学術雑誌）

Homology of an acrosome-reacted sperm-specific antigen to CD46

Masaru Okabe, Xing Ying, Morio Nagira, Masahito Ikawa, Yasuhiro Kohama, Tsutomu Mimura, Keiichi Tanaka

Journal of Pharmacobio-Dynamics　Vol. 15　No. 8　p. 455-459　1992年　研究論文（学術雑誌）

RNA-binding protein ptbp1 regulates alternative splicing and transcriptome in spermatogonia and maintains spermatogenesis in concert with nanos3

Manami Senoo, Hiroshi Hozoji, Yu Ishikawa-Yamauchi, Takashi Takijiri, Sho Ohta, Tomoyo Ukai, Mio Kabata, Takuya Yamamoto, Yasuhiro Yamada, Masahito Ikawa, Manabu Ozawa

Journal of Reproduction and Development　Vol. 66　No. 5　p. 459-467　1905年7月12日　研究論文（学術雑誌）

Nexin-Dynein regulatory complex component DRC7 but not FBXL13 is required for sperm flagellum formation and male fertility in mice

Akane Morohoshi, Haruhiko Miyata, Keisuke Shimada, Kaori Nozawa, Takafumi Matsumura, Ryuji Yanase, Kogiku Shiba, Kazuo Inaba, Masahito Ikawa

PLoS Genetics　Vol. 16　No. 1　1905年7月12日　研究論文（学術雑誌）