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The Rubicon–WIPI axis regulates exosome biogenesis during ageing
Kyosuke Yanagawa, Akiko Kuma, Maho Hamasaki, Shunbun Kita, Tadashi Yamamuro, Kohei Nishino, Shuhei Nakamura, Hiroko Omori, Tatsuya Kaminishi, Satoshi Oikawa, Yoshio Kato, Ryuya Edahiro, Ryosuke Kawagoe, Takako Taniguchi, Yoko Tanaka, Takayuki Shima, Keisuke Tabata, Miki Iwatani, Nao Bekku, Rikinari Hanayama, Yukinori Okada, Takayuki Akimoto, Hidetaka Kosako, Akiko Takahashi, Iichiro Shimomura, Yasushi Sakata, Tamotsu Yoshimori
Nature Cell Biology Vol. 26 No. 9 p. 1558-1570 2024年8月22日 研究論文(学術雑誌)
出版者・発行元:Springer Science and Business Media LLC
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YIPF3 and YIPF4 regulate autophagic turnover of the Golgi apparatus
Shinri Kitta, Tatsuya Kaminishi, Momoko Higashi, Takayuki Shima, Kohei Nishino, Nobuhiro Nakamura, Hidetaka Kosako, Tamotsu Yoshimori, Akiko Kuma
The EMBO Journal 2024年5月31日 研究論文(学術雑誌)
出版者・発行元:Springer Science and Business Media LLC
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Lysophagy protects against propagation of α-synuclein aggregation through ruptured lysosomal vesicles
Keita Kakuda, Kensuke Ikenaka, Akiko Kuma, Junko Doi, César Aguirre, Nan Wang, Takahiro Ajiki, Chi-Jing Choong, Yasuyoshi Kimura, Shaymaa Mohamed Mohamed Badawy, Takayuki Shima, Shuhei Nakamura, Kousuke Baba, Seiichi Nagano, Yoshitaka Nagai, Tamotsu Yoshimori, Hideki Mochizuki
Proceedings of the National Academy of Sciences Vol. 121 No. 1 2023年12月26日 研究論文(学術雑誌)
出版者・発行元:Proceedings of the National Academy of Sciences
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The TMEM192-mKeima probe specifically assays lysophagy and reveals its initial steps
Takayuki Shima, Monami Ogura, Ruriko Matsuda, Shuhei Nakamura, Natsuko Jin, Tamotsu Yoshimori, Akiko Kuma
Journal of Cell Biology Vol. 222 No. 12 2023年10月6日 研究論文(学術雑誌)
出版者・発行元:Rockefeller University Press
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Author Correction: LC3 lipidation is essential for TFEB activation during the lysosomal damage response to kidney injury.
Shuhei Nakamura, Saki Shigeyama, Satoshi Minami, Takayuki Shima, Shiori Akayama, Tomoki Matsuda, Alessandra Esposito, Gennaro Napolitano, Akiko Kuma, Tomoko Namba-Hamano, Jun Nakamura, Kenichi Yamamoto, Miwa Sasai, Ayaka Tokumura, Mika Miyamoto, Yukako Oe, Toshiharu Fujita, Seigo Terawaki, Atsushi Takahashi, Maho Hamasaki, Masahiro Yamamoto, Yukinori Okada, Masaaki Komatsu, Takeharu Nagai, Yoshitsugu Takabatake, Haoxing Xu, Yoshitaka Isaka, Andrea Ballabio, Tamotsu Yoshimori
Nature cell biology Vol. 24 No. 11 p. 1677-1679 2022年11月
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Rubicon prevents autophagic degradation of GATA4 to promote Sertoli cell function
Tadashi Yamamuro, Shuhei Nakamura, Yu Yamano, Tsutomu Endo, Kyosuke Yanagawa, Ayaka Tokumura, Takafumi Matsumura, Kiyonori Kobayashi, Hideto Mori, Yusuke Enokidani, Gota Yoshida, Hitomi Imoto, Tsuyoshi Kawabata, Maho Hamasaki, Akiko Kuma, Sohei Kuribayashi, Kentaro Takezawa, Yuki Okada, Manabu Ozawa, Shinichiro Fukuhara, Takashi Shinohara, Masahito Ikawa, Tamotsu Yoshimori
PLOS Genetics Vol. 17 No. 8 p. e1009688-e1009688 2021年8月5日 研究論文(学術雑誌)
出版者・発行元:Public Library of Science (PLoS)
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Alternative mitochondrial quality control mediated by extracellular release
Chi-Jing Choong, Tatsusada Okuno, Kensuke Ikenaka, Kousuke Baba, Hideki Hayakawa, Masato Koike, Mutsumi Yokota, Junko Doi, Keita Kakuda, Toshihide Takeuchi, Akiko Kuma, Shuhei Nakamura, Yoshitaka Nagai, Seiichi Nagano, Tamotsu Yoshimori, Hideki Mochizuki
Autophagy Vol. 17 No. 10 p. 1-13 2020年12月10日 研究論文(学術雑誌)
出版者・発行元:Informa UK Limited
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Age-dependent loss of adipose Rubicon promotes metabolic disorders via excess autophagy
Tadashi Yamamuro, Tsuyoshi Kawabata, Atsunori Fukuhara, Shotaro Saita, Shuhei Nakamura, Hikari Takeshita, Mari Fujiwara, Yusuke Enokidani, Gota Yoshida, Keisuke Tabata, Maho Hamasaki, Akiko Kuma, Koichi Yamamoto, Iichiro Shimomura, Tamotsu Yoshimori
Nature Communications Vol. 11 No. 1 p. 4150-4150 2020年12月 研究論文(学術雑誌)
出版者・発行元:Springer Science and Business Media LLC
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LC3 lipidation is essential for TFEB activation during the lysosomal damage response to kidney injury
Shuhei Nakamura, Saki Shigeyama, Satoshi Minami, Takayuki Shima, Shiori Akayama, Tomoki Matsuda, Alessandra Esposito, Gennaro Napolitano, Akiko Kuma, Tomoko Namba-Hamano, Jun Nakamura, Kenichi Yamamoto, Miwa Sasai, Ayaka Tokumura, Mika Miyamoto, Yukako Oe, Toshiharu Fujita, Seigo Terawaki, Atsushi Takahashi, Maho Hamasaki, Masahiro Yamamoto, Yukinori Okada, Masaaki Komatsu, Takeharu Nagai, Yoshitsugu Takabatake, Haoxing Xu, Yoshitaka Isaka, Andrea Ballabio, Tamotsu Yoshimori
Nature Cell Biology Vol. 22 No. 10 p. 1252-1263 2020年10月 研究論文(学術雑誌)
出版者・発行元:Springer Science and Business Media LLC
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Loss of autophagy impairs physiological steatosis by accumulation of NCoR1
Takahashi SS, Sou YS, Saito T, Kuma A, Yabe T, Sugiura Y, Lee HC, Suematsu M, Yokomizo T, Koike M, Terai S, Mizushima N, Waguri S, Komatsu M
Life Sci Alliance Vol. 3 No. 1 2019年12月 研究論文(学術雑誌)
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Autophagy regulates lipid metabolism through selective turnover of NCoR1.
Saito T, Kuma A, Sugiura Y, Ichimura Y, Obata M, Kitamura H, Okuda S, Lee HC, Ikeda K, Kanegae Y, Saito I, Auwerx J, Motohashi H, Suematsu M, Soga T, Yokomizo T, Waguri S, Mizushima N, Komatsu M
Nature communications Vol. 10 No. 1 p. 1567-1567 2019年4月 研究論文(学術雑誌)
出版者・発行元:
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Transgenic rescue of Atg5-null mice from neonatal lethality with neuron-specific expression of ATG5: Systemic analysis of adult Atg5-deficient mice
Saori R. Yoshii, Akiko Kuma, Noboru Mizushima
AUTOPHAGY Vol. 13 No. 4 p. 763-764 2017年 研究論文(学術雑誌)
出版者・発行元:TAYLOR & FRANCIS INC
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Autophagy-monitoring and autophagy-deficient mice
Akiko Kuma, Masaaki Komatsu, Noboru Mizushima
AUTOPHAGY Vol. 13 No. 10 p. 1619-1628 2017年 研究論文(学術雑誌)
出版者・発行元:TAYLOR & FRANCIS INC
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Systemic Analysis of Atg5-Null Mice Rescued from Neonatal Lethality by Transgenic ATG5 Expression in Neurons
Saori R. Yoshii, Akiko Kuma, Takumi Akashi, Taichi Hara, Atsushi Yamamoto, Yoshitaka Kurikawa, Eisuke Itakura, Satoshi Tsukamoto, Hiroshi Shitara, Yoshinobu Eishi, Noboru Mizushima
DEVELOPMENTAL CELL Vol. 39 No. 1 p. 116-130 2016年10月 研究論文(学術雑誌)
出版者・発行元:CELL PRESS
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Cycloheximide inhibits starvation-induced autophagy through mTORC1 activation
Takako Watanabe-Asano, Akiko Kuma, Noboru Mizushima
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Vol. 445 No. 2 p. 334-339 2014年3月 研究論文(学術雑誌)
出版者・発行元:ACADEMIC PRESS INC ELSEVIER SCIENCE
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Differential contribution of insulin and amino acids to the mtorc1-autophagy pathway in the liver and muscle
Takako Naito, Akiko Kuma, Noboru Mizushima
Journal of Biological Chemistry Vol. 288 No. 29 p. 21074-21081 2013年7月19日 研究論文(学術雑誌)
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Proteasome-dependent activation of mammalian target of rapamycin complex 1 (mTORC1) is essential for autophagy suppression and muscle remodeling following denervation (vol 288, pg 1125, 2013)
Pham Nguyen Quy, Kuma Akiko, Pierre Philippe, Mizushima Noboru
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 288 No. 19 2013年5月10日
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No ATG is an island-the connection of autophagy with diverse pathways and functions
Masaaki Komatsu, Akiko Kuma, Koji Okamoto
EMBO REPORTS Vol. 14 No. 3 p. 219-221 2013年3月
出版者・発行元:NATURE PUBLISHING GROUP
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Proteasome-dependent Activation of Mammalian Target of Rapamycin Complex 1 (mTORC1) Is Essential for Autophagy Suppression and Muscle Remodeling Following Denervation
Pham Nguyen Quy, Akiko Kuma, Philippe Pierre, Noboru Mizushima
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 288 No. 2 p. 1125-1134 2013年1月 研究論文(学術雑誌)
出版者・発行元:AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
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[Physiological role of autophagy in metabolism and its regulation mechanism].
Watanabe T, Kuma A, Mizushima N
Nihon rinsho. Japanese journal of clinical medicine Vol. 69 Suppl 1 p. 775-781 2011年1月
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Physiological role of autophagy as an intracellular recycling system: With an emphasis on nutrient metabolism
Akiko Kuma, Noboru Mizushima
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY Vol. 21 No. 7 p. 683-690 2010年9月 研究論文(学術雑誌)
出版者・発行元:ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
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[Autophagy in embryogenesis and cell differentiation].
Mizushima N, Tsukamoto S, Kuma A
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme Vol. 53 No. 16 Suppl p. 2170-2174 2008年12月 研究論文(学術雑誌)
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The role of autophagy during the oocyte-to-embryo transition
Satoshi Tsukamoto, Akiko Kuma, Noboru Mizushima
AUTOPHAGY Vol. 4 No. 8 p. 1076-1078 2008年11月 研究論文(学術雑誌)
出版者・発行元:LANDES BIOSCIENCE
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Autophagy is essential for preimplantation development of mouse embryos
Satoshi Tsukamoto, Akiko Kuma, Mirei Murakami, Chieko Kishi, Akitsugu Yamamoto, Noboru Mizushima
SCIENCE Vol. 321 No. 5885 p. 117-120 2008年7月 研究論文(学術雑誌)
出版者・発行元:AMER ASSOC ADVANCEMENT SCIENCE
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Chromosomal mapping of the GFP-LC3 transgene in GFP-LC3 mice
Akiko Kuma, Noboru Mizushima
AUTOPHAGY Vol. 4 No. 1 p. 61-62 2008年1月 研究論文(学術雑誌)
出版者・発行元:LANDES BIOSCIENCE
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Autophagosomes in GFP-LC3 transgenic mice
Noboru Mizushima, Akiko Kuma
Methods in Molecular Biology Vol. 445 p. 119-124 2008年 研究論文(学術雑誌)
出版者・発行元:Humana Press
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LC3, an autophagosome marker, can be incorporated into protein aggregates independent of autophagy
Akiko Kuma, Makoto Matsui, Noboru Mizushima
AUTOPHAGY Vol. 3 No. 4 p. 323-328 2007年7月 研究論文(学術雑誌)
出版者・発行元:LANDES BIOSCIENCE
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Physiological role of autophagy in protein metabolism and the mechanism regulating autophagy in mammals
Mizushima Noboru, Hara Taichi, Kuma Akiko, Sunayama Jun
AUTOPHAGY Vol. 2 No. 4 2006年10月
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[Autophagy in differentiation and development].
Kuma A, Mizushima N
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme Vol. 51 No. 10 Suppl p. 1503-1506 2006年8月
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Organelle degradation during the lens and erythroid differentiation is independent of autophagy
M Matsui, A Yamamoto, A Kuma, Y Ohsumi, N Mizushima
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Vol. 339 No. 2 p. 485-489 2006年1月 研究論文(学術雑誌)
出版者・発行元:ACADEMIC PRESS INC ELSEVIER SCIENCE
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The role of autophagy during the early neonatal starvation period
A Kuma, M Hatano, M Matsui, A Yamamoto, H Nakaya, T Yoshimori, Y Ohsumi, T Tokuhisa, N Mizushima
NATURE Vol. 432 No. 7020 p. 1032-1036 2004年12月 研究論文(学術雑誌)
出版者・発行元:NATURE PUBLISHING GROUP
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Alfy, a novel FYVE-domain-containing protein associated with protein granules and autophagic membranes
A Simonsen, HCG Birkeland, DJ Gillooly, N Mizushima, A Kuma, T Yoshimori, T Slagsvold, A Brech, H Stenmark
JOURNAL OF CELL SCIENCE Vol. 117 No. 18 p. 4239-4251 2004年8月 研究論文(学術雑誌)
出版者・発行元:COMPANY OF BIOLOGISTS LTD
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Binding of 14-3-3 beta but not 14-3-3 sigma controls the cytoplasmic localization of CDC25B: binding site preferences of 14-3-3 subtypes and the subcellular localization of CDC25B
S Uchida, A Kuma, M Ohtsubo, M Shimura, M Hirata, H Nakagama, T Matsunaga, Y Ishizaka, K Yamashita
JOURNAL OF CELL SCIENCE Vol. 117 No. 14 p. 3011-3020 2004年6月 研究論文(学術雑誌)
出版者・発行元:COMPANY OF BIOLOGISTS LTD
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Mouse Apg16L, a novel WD-repeat protein, targets to the autophagic isolation membrane with the Apg12-Apg5 conjugate
N Mizushima, A Kuma, Y Kobayashi, A Yamamoto, M Matsubae, T Takao, T Natsume, Y Ohsumi, T Yoshimori
JOURNAL OF CELL SCIENCE Vol. 116 No. 9 p. 1679-1688 2003年5月 研究論文(学術雑誌)
出版者・発行元:COMPANY OF BIOLOGISTS LTD
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Formation of the similar to 350-kDa Apg12-Apg5 center dot Apg16 multimeric complex, mediated by Apg16 oligomerization, is essential for autophagy in yeast
A Kuma, N Mizushima, N Ishihara, Y Ohsumi
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 277 No. 21 p. 18619-18625 2002年5月 研究論文(学術雑誌)
出版者・発行元:AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC