Early acquisition of S-specific Tfh clonotypes after SARS-CoV-2 vaccination is associated with the longevity of anti-S antibodies.

Xiuyuan Lu, Hiroki Hayashi, Eri Ishikawa, Yukiko Takeuchi, Julian Vincent Tabora Dychiao, Hironori Nakagami, Sho Yamasaki

eLife　Vol. 12　2024年5月8日　研究論文（学術雑誌）

Sulfated bile acid is a host-derived ligand for MAIT cells.

Emi Ito, Shinsuke Inuki, Yoshihiro Izumi, Masatomo Takahashi, Yuki Dambayashi, Lisa Ciacchi, Wael Awad, Ami Takeyama, Kensuke Shibata, Shotaro Mori, Jeffrey Y W Mak, David P Fairlie, Takeshi Bamba, Eri Ishikawa, Masamichi Nagae, Jamie Rossjohn, Sho Yamasaki

Science immunology　Vol. 9　No. 91　2024年1月26日　研究論文（学術雑誌）

Linkage-Editing Pseudo-Glycans: A Reductive α-Fluorovinyl-C-Glycosylation Strategy to Create Glycan Analogs with Altered Biological Activities.

Takahiro Moriyama, Makoto Yoritate, Naoki Kato, Azusa Saika, Wakana Kusuhara, Shunsuke Ono, Takahiro Nagatake, Hiroyuki Koshino, Noriaki Kiya, Natsuho Moritsuka, Riko Tanabe, Yu Hidaka, Kazuteru Usui, Suzuka Chiba, Noyuri Kudo, Rintaro Nakahashi, Kazunobu Igawa, Hiroaki Matoba, Katsuhiko Tomooka, Eri Ishikawa, Shunji Takahashi, Jun Kunisawa, Sho Yamasaki, Go Hirai

Journal of the American Chemical Society　Vol. 146　No. 3　p. 2237-2247　2024年1月24日　研究論文（学術雑誌）

ヘリコバクター・ピロリに対する免疫応答と胃炎誘導機構

永田 雅大, 石川 絵里, 山崎 晶

日本ヘリコバクター学会誌　Vol. 25　No. 2　p. 122-128　2024年1月

Ligand-Controlled Stereoselective Synthesis and Biological Activity of 2-Exomethylene Pseudo-glycoconjugates: Discovery of Mincle-Selective Ligands.

Takahiro Ikazaki, Eri Ishikawa, Hiroto Tamashima, Hisako Akiyama, Yusuke Kimuro, Makoto Yoritate, Hiroaki Matoba, Akihiro Imamura, Hideharu Ishida, Sho Yamasaki, Go Hirai

Angewandte Chemie (International ed. in English)　Vol. 62　No. 22　2023年5月22日　研究論文（学術雑誌）

A terpene nucleoside from M. tuberculosis induces lysosomal lipid storage in foamy macrophages.

Melissa Bedard, Sanne van der Niet, Elliott M Bernard, Gregory Babunovic, Tan-Yun Cheng, Beren Aylan, Anita E Grootemaat, Sahadevan Raman, Laure Botella, Eri Ishikawa, Mary P O'Sullivan, Seónadh O'Leary, Jacob A Mayfield, Jeffrey Buter, Adriaan J Minnaard, Sarah M Fortune, Leon O Murphy, Daniel S Ory, Joseph Keane, Sho Yamasaki, Maximiliano G Gutierrez, Nicole van der Wel, D Branch Moody

The Journal of clinical investigation　Vol. 133　No. 6　2023年3月15日　研究論文（学術雑誌）

Mycobacterial mycolic acids trigger inhibitory receptor Clec12A to suppress host immune responses.

Naoya Nishimura, Noriyuki Tomiyasu, Shota Torigoe, Satoru Mizuno, Hanako Fukano, Eri Ishikawa, Harutaka Katano, Yoshihiko Hoshino, Kazuhiro Matsuo, Masatomo Takahashi, Yoshihiro Izumi, Takeshi Bamba, Koichi Akashi, Sho Yamasaki

Tuberculosis (Edinburgh, Scotland)　Vol. 138　p. 102294-102294　2023年1月1日　研究論文（学術雑誌）

Symbiotic bacteria-dependent expansion of MR1-reactive T cells causes autoimmunity in the absence of Bcl11b.

Kensuke Shibata, Chihiro Motozono, Masamichi Nagae, Takashi Shimizu, Eri Ishikawa, Daisuke Motooka, Daisuke Okuzaki, Yoshihiro Izumi, Masatomo Takahashi, Nao Fujimori, James B Wing, Takahide Hayano, Yoshiyuki Asai, Takeshi Bamba, Yoshihiro Ogawa, Makoto Furutani-Seiki, Mutsunori Shirai, Sho Yamasaki

Nature communications　Vol. 13　No. 1　p. 6948-6948　2022年11月14日　研究論文（学術雑誌）

Identification of conserved SARS-CoV-2 spike epitopes that expand public cTfh clonotypes in mild COVID-19 patients.

Xiuyuan Lu, Yuki Hosono, Masamichi Nagae, Shigenari Ishizuka, Eri Ishikawa, Daisuke Motooka, Yuki Ozaki, Nicolas Sax, Yuichi Maeda, Yasuhiro Kato, Takayoshi Morita, Ryo Shinnakasu, Takeshi Inoue, Taishi Onodera, Takayuki Matsumura, Masaharu Shinkai, Takashi Sato, Shota Nakamura, Shunsuke Mori, Teru Kanda, Emi E Nakayama, Tatsuo Shioda, Tomohiro Kurosaki, Kiyoshi Takeda, Atsushi Kumanogoh, Hisashi Arase, Hironori Nakagami, Kazuo Yamashita, Yoshimasa Takahashi, Sho Yamasaki

The Journal of experimental medicine　Vol. 218　No. 12　2021年12月6日　研究論文（学術雑誌）

Protein Kinase D2 drives chylomicron-mediated lipid transport in the intestine and promotes obesity

Jonathan Trujillo-Viera, Rabih El-Merahbi, Vanessa Schmidt, Till Karwen, Angel Loza-Valdes, Akim Strohmeyer, Saskia Reuter, Minhee Noh, Magdalena Wit, Izabela Hawro, Sabine Mocek, Christina Fey, Alexander E. Mayer, Mona C. Löffler, Ilka Wilhelmi, Marco Metzger, Eri Ishikawa, Sho Yamasaki, Monika Rau, Andreas Geier, Mohammed Hankir, Florian Seyfried, Martin Klingenspor, Grzegorz Sumara

EMBO Molecular Medicine　Vol. 13　No. 5　2021年5月7日　研究論文（学術雑誌）

Helicobacter pylori metabolites exacerbate gastritis through C-type lectin receptors

Masahiro Nagata, Kenji Toyonaga, Eri Ishikawa, Shojiro Haji, Nobuyuki Okahashi, Masatomo Takahashi, Yoshihiro Izumi, Akihiro Imamura, Koichi Takato, Hideharu Ishida, Shigenori Nagai, Petr Illarionov, Bridget L. Stocker, Mattie S.M. Timmer, Dylan G.M. Smith, Spencer J. Williams, Takeshi Bamba, Tomofumi Miyamoto, Makoto Arita, Ben J. Appelmelk, Sho Yamasaki

Journal of Experimental Medicine　Vol. 218　No. 1　2021年1月4日　研究論文（学術雑誌）

Synthetic mycobacterial diacyl trehaloses reveal differential recognition by human T cell receptors and the C-type lectin Mincle

Josephine F. Reijneveld, Mira Holzheimer, David C. Young, Kattya Lopez, Sara Suliman, Judith Jimenez, Roger Calderon, Leonid Lecca, Megan B. Murray, Eri Ishikawa, Sho Yamasaki, Adriaan J. Minnaard, D. Branch Moody, Ildiko Van Rhijn

Scientific Reports　Vol. 11　No. 1　2021年1月1日　研究論文（学術雑誌）

Deletion of Protein Kinase D3 Promotes Liver Fibrosis in Mice

Shuya Zhang, Huan Liu, Meimei Yin, Xiuying Pei, Angelika Hausser, Eri Ishikawa, Sho Yamasaki, Zheng Gen Jin

Hepatology　Vol. 72　No. 5　p. 1717-1734　2020年11月1日　研究論文（学術雑誌）

Asymmetric Total Synthesis of Mycobacterial Diacyl Trehaloses Demonstrates a Role for Lipid Structure in Immunogenicity

Mira Holzheimer, Josephine F. Reijneveld, Alexandrea K. Ramnarine, Georgios Misiakos, David C. Young, Eri Ishikawa, Tan Yun Cheng, Sho Yamasaki, D. Branch Moody, Ildiko Van Rhijn, Adriaan J. Minnaard

ACS Chemical Biology　Vol. 15　No. 7　p. 1835-1841　2020年7月17日　研究論文（学術雑誌）

Discovery of Salmonella trehalose phospholipids reveals functional convergence with mycobacteria

Peter Reinink, Jeffrey Buter, Vivek K. Mishra, Eri Ishikawa, Tan Yun Cheng, Peter T.J. Willemsen, Steffen Porwollik, Patrick J. Brennan, Eva Heinz, Jacob A. Mayfield, Gordon Dougan, Cécile A. Van Els, Vincenzo Cerundolo, Giorgio Napolitani, Sho Yamasaki, Adriaan J. Minnaard, Michael McClelland, D. Branch Moody, Ildiko Van Rhijn

Journal of Experimental Medicine　Vol. 216　No. 4　p. 757-771　2019年4月　研究論文（学術雑誌）

Lipoteichoic acid anchor triggers Mincle to drive protective immunity against invasive group A Streptococcus infection

Takashi Imai, Takayuki Matsumura, Sabine Mayer-Lambertz, Christine A. Wells, Eri Ishikawa, Suzanne K. Butcher, Timothy C. Barnett, Mark J. Walker, Akihiro Imamura, Hideharu Ishida, Tadayoshi Ikebe, Tomofumi Miyamoto, Manabu Ato, Shouichi Ohga, Bernd Lepenies, Nina M. Van Sorge, Sho Yamasaki

Proceedings of the National Academy of Sciences of the United States of America　Vol. 115　No. 45　p. E10662-E10671　2018年11月6日　研究論文（学術雑誌）

Lipidated Brartemicin Analogues Are Potent Th1-Stimulating Vaccine Adjuvants

Amy J. Foster, Masahiro Nagata, Xiuyuan Lu, Amy T. Lynch, Zakaria Omahdi, Eri Ishikawa, Sho Yamasaki, Mattie S.M. Timmer, Bridget L. Stocker

Journal of Medicinal Chemistry　Vol. 61　No. 3　p. 1045-1060　2018年2月8日　研究論文（学術雑誌）

Spontaneous chondroma formation in CD2-Cre-driven Erk-deficient mice

Moe Shiokawa, Xiuyuan Lu, Yasunobu Miyake, Eri Ishikawa, Gilles Pagès, Jacques Pouysségur, Masato Ogata, Sho Yamasaki

International Immunology　Vol. 29　No. 10　p. 479-485　2017年10月1日　研究論文（学術雑誌）

Intracellular metabolite β-glucosylceramide is an endogenous Mincle ligand possessing immunostimulatory activity.

Nagata M, Izumi Y, Ishikawa E, Kiyotake R, Doi R, Iwai S, Omahdi Z, Yamaji T, Miyamoto T, Bamba T, Yamasaki S

Proceedings of the National Academy of Sciences of the United States of America　Vol. 114　No. 16　p. E3285-E3294　2017年4月　研究論文（学術雑誌）

Recognition of Mycobacterial Lipids by Immune Receptors

Eri Ishikawa, Daiki Mori, Sho Yamasaki

Trends in Immunology　Vol. 38　No. 1　p. 66-76　2017年1月1日

Protein kinase D regulates positive selection of CD4+ thymocytes through phosphorylation of SHP-1

Eri Ishikawa, Hidetaka Kosako, Tomoharu Yasuda, Masaki Ohmuraya, Kimi Araki, Tomohiro Kurosaki, Takashi Saito, Sho Yamasaki

Nature Communications　Vol. 7　2016年9月27日　研究論文（学術雑誌）

Human mincle binds to cholesterol crystals and triggers innate immune responses

Ryoko Kiyotake, Masatsugu Oh-Hora, Eri Ishikawa, Tomofumi Miyamoto, Tatsuro Ishibashi, Sho Yamasaki

Journal of Biological Chemistry　Vol. 290　No. 42　p. 25322-25332　2015年10月16日　研究論文（学術雑誌）

Dectin-2 is a direct receptor for mannose-capped lipoarabinomannan of mycobacteria

Akiko Yonekawa, Shinobu Saijo, Yoshihiko Hoshino, Yasunobu Miyake, Eri Ishikawa, Maho Suzukawa, Hiromasa Inoue, Masato Tanaka, Mitsutoshi Yoneyama, Masatsugu Oh-hora, Koichi Akashi, Sho Yamasaki

Immunity　Vol. 41　No. 3　p. 402-413　2014年9月18日　研究論文（学術雑誌）

Germ-line elimination of electric charge on pre-T-cell receptor (TCR) impairs autonomous signaling for β-selection and tCr repertoire formation

Eri Ishikawa, Yasunobu Miyake, Hiromitsu Hara, Takashi Saito, Sho Yamasaki

Proceedings of the National Academy of Sciences of the United States of America　Vol. 107　No. 46　p. 19979-19984　2010年11月16日　研究論文（学術雑誌）

Self and nonself recognition through C-type lectin receptor, Mincle

Yasunobu Miyake, Eri Ishikawa, Tetsuaki Ishikawa, Sho Yamasaki

Self/Nonself - Immune Recognition and Signaling　Vol. 1　No. 4　p. 310-313　2010年10月

Direct recognition of the mycobacterial glycolipid, trehalose dimycolate, by C-type lectin Mincle

Eri Ishikawa, Tetsuaki Ishikawa, Yasu S. Morita, Kenji Toyonaga, Hisakata Yamada, Osamu Takeuchi, Taroh Kinoshita, Shizuo Akira, Yasunobu Yoshikai, Sho Yamasaki

Journal of Experimental Medicine　Vol. 206　No. 13　p. 2879-2888　2009年12月21日　研究論文（学術雑誌）

C-type lectin Mincle is an activating receptor for pathogenic fungus, Malassezia

Sho Yamasaki, Makoto Matsumoto, Osamu Takeuchi, Tetsuhiro Matsuzawa, Eri Ishikawa, Machie Sakuma, Hiroaki Tateno, Jun Uno, Jun Hirabayashi, Yuzuru Mikami, Kiyoshi Takeda, Shizuo Akira, Takashi Saito

Proceedings of the National Academy of Sciences of the United States of America　Vol. 106　No. 6　p. 1897-1902　2009年2月10日　研究論文（学術雑誌）

Selective impairment of FcεRI-mediated allergic reaction in Gads-deficient mice

Sho Yamasaki, Mitsuyo Takase-Utsugi, Eri Ishikawa, Machie Sakuma, Keigo Nishida, Takashi Saito, Osami Kanagawa

International Immunology　Vol. 20　No. 10　p. 1289-1297　2008年　研究論文（学術雑誌）

Mincle is an ITAM-coupled activating receptor that senses damaged cells

Sho Yamasaki, Eri Ishikawa, Machie Sakuma, Hiromitsu Hara, Koji Ogata, Takashi Saito

Nature Immunology　Vol. 9　No. 10　p. 1179-1188　2008年　研究論文（学術雑誌）

LAT and NTAL mediate immunoglobulin E-induced sustained extracellular signal-regulated kinase activation critical for mast cell survival

Sho Yamasaki, Eri Ishikawa, Machie Sakuma, Osami Kanagawa, Alec M. Cheng, Bernard Malissen, Takashi Saito

Molecular and Cellular Biology　Vol. 27　No. 12　p. 4406-4415　2007年6月　研究論文（学術雑誌）

Mechanistic basis of pre-T cell receptor-mediated autonomous signaling critical for thymocyte development

Sho Yamasaki, Eri Ishikawa, Machie Sakuma, Koji Ogata, Kumiko Sakata-Sogawa, Michio Hiroshima, David L. Wiest, Makio Tokunaga, Takashi Saito

Nature Immunology　Vol. 7　No. 1　p. 67-75　2006年1月　研究論文（学術雑誌）

Role of tumor necrosis factor-related apoptosis-inducing ligand in immune response to influenza virus infection in mice

Eri Ishikawa, Masatoshi Nakazawa, Masahiro Yoshinari, Mutsuhiko Minami

Journal of Virology　Vol. 79　No. 12　p. 7658-7663　2005年6月　研究論文（学術雑誌）

The quantity and duration of FcRγ signals determine mast cell degranulation and survival

Sho Yamasaki, Eri Ishikawa, Masayuki Kohno, Takashi Saito

Blood　Vol. 103　No. 8　p. 3093-3101　2004年4月　研究論文（学術雑誌）