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研究

社会活動

その他の活動

竹田 潔

Takeda Kiyoshi

医学系研究科 医学専攻,教授

keyword 免疫学

研究内容・専門分野

  • ライフサイエンス,免疫学

論文

  • Chlamydia evasion of neutrophil host defense results in NLRP3 dependent myeloid-mediated sterile inflammation through the purinergic P2X7 receptor,Chunfu Yang,Lei Lei,John W.Marshall Collins,Michael Briones,Li Ma,Gail L. Sturdevant,Hua Su,Anuj K. Kashyap,David Dorward,Kevin W. Bock,Ian N. Moore,Christine Bonner,Chih Yu Chen,Craig A. Martens,Stacy Ricklefs,Masahiro Yamamoto,Kiyoshi Takeda,Yoichiro Iwakura,Grant McClarty,Harlan D. Caldwell,Nature Communications,Vol. 12,No. 1,2021年12月,研究論文(学術雑誌)
  • The ATP-hydrolyzing ectoenzyme E-NTPD8 attenuates colitis through modulation of P2X4 receptor-dependent metabolism in myeloid cells.,Haruka Tani,Bo Li,Takashi Kusu,Ryu Okumura,Junichi Nishimura,Daisuke Okuzaki,Daisuke Motooka,Shoya Arakawa,Asuka Mori,Terukazu Yoshihara,Takayuki Ogino,Shih-Han Tsai,Yoki Furuta,Masato Muneta,Shota Nakamura,Eiichiro Fukusaki,Kimiko Yamamoto,Hideo Yagita,Hisako Kayama,Kiyoshi Takeda,Proceedings of the National Academy of Sciences of the United States of America,Vol. 118,No. 39,2021年09月28日,研究論文(学術雑誌)
  • Metagenome-wide association study revealed disease-specific landscape of the gut microbiome of systemic lupus erythematosus in Japanese,Yoshihiko Tomofuji,Yuichi Maeda,Eri Oguro-Igashira,Toshihiro Kishikawa,Kenichi Yamamoto,Kyuto Sonehara,Daisuke Motooka,Yuki Matsumoto,Hidetoshi Matsuoka,Maiko Yoshimura,Mayu Yagita,Takuro Nii,Shiro Ohshima,Shota Nakamura,Hidenori Inohara,Kiyoshi Takeda,Atsushi Kumanogoh,Yukinori Okada,Annals of the Rheumatic Diseases,BMJ,p. annrheumdis-2021,2021年08月23日,研究論文(学術雑誌)
  • Protease inhibitory activity of secretory leukocyte protease inhibitor ameliorates murine experimental colitis by protecting the intestinal epithelial barrier,Sotaro Ozaka,Akira Sonoda,Shimpei Ariki,Naganori Kamiyama,Shinya Hidano,Nozomi Sachi,Kanako Ito,Yoko Kudo,Mizuki Minata,Benjawan Saechue,Astri Dewayani,Thanyakorn Chalalai,Yasuhiro Soga,Yuya Takahashi,Chiaki Fukuda,Kazuhiro Mizukami,Ryu Okumura,Hisako Kayama,Kazunari Murakami,Kiyoshi Takeda,Takashi Kobayashi,Genes to Cells,Wiley,2021年08月17日,研究論文(学術雑誌)
  • Gut Microbiota-Derived Short-Chain Fatty Acids Promote Prostate Cancer Growth via IGF1 Signaling.,Makoto Matsushita,Kazutoshi Fujita,Takuji Hayashi,Hisako Kayama,Daisuke Motooka,Hiroaki Hase,Kentaro Jingushi,Gaku Yamamichi,Satoru Yumiba,Eisuke Tomiyama,Yoko Koh,Yujiro Hayashi,Kosuke Nakano,Cong Wang,Yu Ishizuya,Taigo Kato,Koji Hatano,Atsunari Kawashima,Takeshi Ujike,Motohide Uemura,Ryoichi Imamura,Maria D C Rodriguez Pena,Jennifer B Gordetsky,George J Netto,Kazutake Tsujikawa,Shota Nakamura,Kiyoshi Takeda,Norio Nonomura,Cancer research,Vol. 81,No. 15,p. 4014-4026,2021年08月01日,研究論文(学術雑誌)
  • Fecal Stream Diversion Changes Intestinal Environment, Modulates Mucosal Barrier, and Attenuates Inflammatory Cells in Crohn's Disease.,Yoshifumi Watanabe,Tsunekazu Mizushima,Ryu Okumura,Shiki Fujino,Takayuki Ogino,Norikatsu Miyoshi,Hidekazu Takahashi,Mamoru Uemura,Chu Matsuda,Hirofumi Yamamoto,Kiyoshi Takeda,Yuichiro Doki,Hidetoshi Eguchi,Digestive diseases and sciences,2021年05月26日,研究論文(学術雑誌)
  • Alleviation of colonic inflammation by Lypd8 in a mouse model of inflammatory bowel diseases (IBD).,Chiao-Ching Hsu,Ryu Okumura,Daisuke Motooka,Reo Sasaki,Shota Nakamura,Tetsuya Iida,Kiyoshi Takeda,International immunology,2021年04月05日,研究論文(学術雑誌)
  • Increased levels of plasma nucleotides in patients with rheumatoid arthritis,Toshihiro Kishikawa,Yuichi Maeda,Takuro Nii,Noriko Arase,Jun Hirata,Ken Suzuki,Kenichi Yamamoto,Tatsuo Masuda,Kotaro Ogawa,Shigeyoshi Tsuji,Masato Matsushita,Hidetoshi Matsuoka,Maiko Yoshimura,Shinichiro Tsunoda,Shiro Ohshima,Masashi Narazaki,Atsushi Ogata,Yukihiko Saeki,Hidenori Inohara,Atsushi Kumanogoh,Kiyoshi Takeda,Yukinori Okada,International Immunology,Oxford University Press (OUP),Vol. 33,No. 2,p. 119-124,2021年01月28日,研究論文(学術雑誌)
  • Oral intake of silica nanoparticles exacerbates intestinal inflammation.,Takao Ogawa,Ryu Okumura,Kazuya Nagano,Tomomi Minemura,Masahiro Izumi,Daisuke Motooka,Shota Nakamura,Tetsuya Iida,Yuichi Maeda,Atsushi Kumanogoh,Yasuo Tsutsumi,Kiyoshi Takeda,Biochemical and biophysical research communications,Vol. 534,p. 540-546,2021年01月01日,研究論文(学術雑誌)
  • Microbiota-derived butyrate limits the autoimmune response by promoting the differentiation of follicular regulatory T cells.,Daisuke Takahashi,Naomi Hoshina,Yuma Kabumoto,Yuichi Maeda,Akari Suzuki,Hiyori Tanabe,Junya Isobe,Takahiro Yamada,Kisara Muroi,Yuto Yanagisawa,Atsuo Nakamura,Yumiko Fujimura,Aiko Saeki,Mizuki Ueda,Ryohtaroh Matsumoto,Hanako Asaoka,Julie M Clarke,Yohsuke Harada,Eiji Umemoto,Noriko Komatsu,Takaharu Okada,Hiroshi Takayanagi,Kiyoshi Takeda,Michio Tomura,Koji Hase,EBioMedicine,Vol. 58,p. 102913-102913,2020年08月,研究論文(学術雑誌)
  • Manipulation of epithelial integrity and mucosal immunity by host and microbiota-derived metabolites.,Hisako Kayama,Kiyoshi Takeda,European journal of immunology,Vol. 50,No. 7,p. 921-931,2020年07月,研究論文(学術雑誌)
  • Sanguisorba officinalis L. derived from herbal medicine prevents intestinal inflammation by inducing autophagy in macrophages.,Asuka Yasueda,Hisako Kayama,Michiko Murohashi,Junichi Nishimura,Koji Wakame,Ken-Ichi Komatsu,Takayuki Ogino,Norikatsu Miyoshi,Hidekazu Takahashi,Mamoru Uemura,Chu Matsuda,Toru Kitagawa,Kiyoshi Takeda,Toshinori Ito,Yuichiro Doki,Hidetoshi Eguchi,Shigeomi Shimizu,Tsunekazu Mizushima,Scientific reports,Vol. 10,No. 1,p. 9972-9972,2020年06月19日,研究論文(学術雑誌)
  • TRPM5 Negatively Regulates Calcium-Dependent Responses in Lipopolysaccharide-Stimulated B Lymphocytes.,Taiki Sakaguchi,Ryu Okumura,Chisato Ono,Daisuke Okuzaki,Takafumi Kawai,Yoshifumi Okochi,Natsuko Tanimura,Mari Murakami,Hisako Kayama,Eiji Umemoto,Hidetaka Kioka,Tomohito Ohtani,Yasushi Sakata,Kensuke Miyake,Yasushi Okamura,Yoshihiro Baba,Kiyoshi Takeda,Cell reports,Vol. 31,No. 10,p. 107755-107755,2020年06月09日,研究論文(学術雑誌)
  • Human NKp44+ Group 3 Innate Lymphoid Cells Associate with Tumor-Associated Tertiary Lymphoid Structures in Colorectal Cancer.,Atsuyo Ikeda,Takayuki Ogino,Hisako Kayama,Daisuke Okuzaki,Junichi Nishimura,Shiki Fujino,Norikatsu Miyoshi,Hidekazu Takahashi,Mamoru Uemura,Chu Matsuda,Hirofumi Yamamoto,Kiyoshi Takeda,Tsunekazu Mizushima,Masaki Mori,Yuichiro Doki,Cancer immunology research,Vol. 8,No. 6,p. 724-731,2020年06月,研究論文(学術雑誌)
  • Interaction Between the Microbiota, Epithelia, and Immune Cells in the Intestine.,Hisako Kayama,Ryu Okumura,Kiyoshi Takeda,Annual review of immunology,Vol. 38,p. 23-48,2020年04月26日,研究論文(学術雑誌)
  • The Xenobiotic Transporter Mdr1 Enforces T Cell Homeostasis in the Presence of Intestinal Bile Acids.,Wei Cao,Hisako Kayama,Mei Lan Chen,Amber Delmas,Amy Sun,Sang Yong Kim,Erumbi S Rangarajan,Kelly McKevitt,Amanda P Beck,Cody B Jackson,Gogce Crynen,Angelos Oikonomopoulos,Precious N Lacey,Gustavo J Martinez,Tina Izard,Robin G Lorenz,Alex Rodriguez-Palacios,Fabio Cominelli,Maria T Abreu,Daniel W Hommes,Sergei B Koralov,Kiyoshi Takeda,Mark S Sundrud,Immunity,Vol. 52,No. 3,p. 571-571,2020年03月17日
  • Some Gammaproteobacteria are enriched within CD14+ macrophages from intestinal lamina propria of Crohn's disease patients versus mucus.,Yuki Sekido,Junichi Nishimura,Kazuhiro Nakano,Takeaki Osu,Cheryl-Emiliane T Chow,Hiroshi Matsuno,Takayuki Ogino,Shiki Fujino,Norikatsu Miyoshi,Hidekazu Takahashi,Mamoru Uemura,Chu Matsuda,Hisako Kayama,Masaki Mori,Yuichiro Doki,Kiyoshi Takeda,Motoi Uchino,Hiroki Ikeuchi,Tsunekazu Mizushima,Scientific reports,Vol. 10,No. 1,p. 2988-2988,2020年02月19日,研究論文(学術雑誌)
  • Metagenome-wide association study of gut microbiome revealed novel aetiology of rheumatoid arthritis in the Japanese population.,Toshihiro Kishikawa,Yuichi Maeda,Takuro Nii,Daisuke Motooka,Yuki Matsumoto,Masato Matsushita,Hidetoshi Matsuoka,Maiko Yoshimura,Shoji Kawada,Satoru Teshigawara,Eri Oguro,Yasutaka Okita,Keisuke Kawamoto,Shinji Higa,Toru Hirano,Masashi Narazaki,Atsushi Ogata,Yukihiko Saeki,Shota Nakamura,Hidenori Inohara,Atsushi Kumanogoh,Kiyoshi Takeda,Yukinori Okada,Annals of the rheumatic diseases,Vol. 79,No. 1,p. 103-111,2020年01月,研究論文(学術雑誌)
  • Lypd8 inhibits attachment of pathogenic bacteria to colonic epithelia.,Ryu Okumura,Toshio Kodama,Chiao-Ching Hsu,Benjamin Heller Sahlgren,Shota Hamano,Takashi Kurakawa,Tetsuya Iida,Kiyoshi Takeda,Mucosal immunology,Vol. 13,No. 1,p. 75-85,2020年01月,研究論文(学術雑誌)
  • Host-microbiota interactions in rheumatoid arthritis.,Yuichi Maeda,Kiyoshi Takeda,Experimental & molecular medicine,Vol. 51,No. 12,p. 1-6,2019年12月11日,研究論文(学術雑誌)
  • Metabolic adaptation to glycolysis is a basic defense mechanism of macrophages for Mycobacterium tuberculosis infection.,Mayuko Osada-Oka,Nobuhito Goda,Hiroyuki Saiga,Masahiro Yamamoto,Kiyoshi Takeda,Yuriko Ozeki,Takehiro Yamaguchi,Tomoyoshi Soga,Yu Tateishi,Katsuyuki Miura,Daisuke Okuzaki,Kazuo Kobayashi,Sohkichi Matsumoto,International immunology,Vol. 31,No. 12,p. 781-793,2019年11月08日,研究論文(学術雑誌)
  • Cholera toxin B induces interleukin-1β production from resident peritoneal macrophages through the pyrin inflammasome as well as the NLRP3 inflammasome.,Takashi Orimo,Izumi Sasaki,Hiroaki Hemmi,Toshiya Ozasa,Yuri Fukuda-Ohta,Tomokazu Ohta,Mio Morinaka,Mariko Kitauchi,Takako Yamaguchi,Yayoi Sato,Takashi Tanaka,Katsuaki Hoshino,Kei-Ichi Katayama,Shinji Fukuda,Kensuke Miyake,Masahiro Yamamoto,Takashi Satoh,Koichi Furukawa,Etsushi Kuroda,Ken J Ishii,Kiyoshi Takeda,Tsuneyasu Kaisho,International immunology,Vol. 31,No. 10,p. 657-668,2019年09月18日,研究論文(学術雑誌)
  • BATF2 prevents T-cell-mediated intestinal inflammation through regulation of the IL-23/IL-17 pathway,Hisako Kayama,Haruka Tani,Shoko Kitada,Anunya Opasawatchai,Ryu Okumura,Daisuke Motooka,Shota Nakamura,Kiyoshi Takeda,International Immunology,Vol. 31,No. 6,p. 371-383,2019年02月19日,研究論文(学術雑誌)
  • Comparison of Japanese and Indian intestinal microbiota shows diet-dependent interaction between bacteria and fungi.,Siddhika Pareek,Takashi Kurakawa,Bhabatosh Das,Daisuke Motooka,Shuuichi Nakaya,Temsunaro Rongsen-Chandola,Nidhi Goyal,Hisako Kayama,Dylan Dodd,Ryu Okumura,Yuichi Maeda,Kosuke Fujimoto,Takuro Nii,Takao Ogawa,Tetsuya Iida,Nita Bhandari,Toshiyuki Kida,Shota Nakamura,G Balakrish Nair,Kiyoshi Takeda,NPJ biofilms and microbiomes,Vol. 5,p. 37-37,2019年,研究論文(学術雑誌)
  • Recasting the Tissue-resident Lymphocyte in Celiac Disease,竹田 潔,Immunity,Vol. 50,p. 549-551,2019年
  • Emerging roles of bile acids in mucosal immunity and inflammation.,竹田 潔,Mucosal Immunol,2019年
  • Hydrogen-Rich Saline Regulates Intestinal Barrier Dysfunction, Dysbiosis, and Bacterial Translocation in a Murine Model of Sepsis.,Mitsunori Ikeda,Kentaro Shimizu,Hiroshi Ogura,Takashi Kurakawa,Eiji Umemoto,Daisuke Motooka,Shota Nakamura,Naotsugu Ichimaru,Kiyoshi Takeda,Shiro Takahara,Shin-Ichi Hirano,Takeshi Shimazu,Shock (Augusta, Ga.),Vol. 50,No. 6,p. 640-647,2018年12月,研究論文(学術雑誌)
  • Heme ameliorates dextran sodium sulfate-induced colitis through providing intestinal macrophages with noninflammatory profiles.,Hisako Kayama,Masako Kohyama,Daisuke Okuzaki,Daisuke Motooka,Soumik Barman,Ryu Okumura,Masato Muneta,Katsuaki Hoshino,Izumi Sasaki,Wataru Ise,Hiroshi Matsuno,Junichi Nishimura,Tomohiro Kurosaki,Shota Nakamura,Hisashi Arase,Tsuneyasu Kaisho,Kiyoshi Takeda,Proceedings of the National Academy of Sciences of the United States of America,Vol. 115,No. 33,p. 8418-8423,2018年08月14日,研究論文(学術雑誌)
  • T Follicular Helper Cell-Germinal Center B Cell Interaction Strength Regulates Entry into Plasma Cell or Recycling Germinal Center Cell Fate,Wataru Ise,Kentaro Fujii,Katsuyuki Shiroguchi,Ayako Ito,Kohei Kometani,Kiyoshi Takeda,Eiryo Kawakami,Kazuo Yamashita,Kazuhiro Suzuki,Takaharu Okada,Tomohiro Kurosaki,Immunity,Cell Press,Vol. 48,No. 4,p. 702-715.e4,2018年04月17日,研究論文(学術雑誌)
  • Non-ischemic heart failure with reduced ejection fraction is associated with altered intestinal microbiota,Themistoklis Katsimichas,Tomohito Ohtani,Daisuke Motooka,Yasumasa Tsukamoto,Hidetaka Kioka,Kei Nakamoto,Shozo Konishi,Misato Chimura,Kaoruko Sengoku,Hiroshi Miyawaki,Taiki Sakaguchi,Ryu Okumura,Konstantinos Theofilis,Tetsuya Iida,Kiyoshi Takeda,Shota Nakamura,Yasushi Sakata,Circulation Journal,Japanese Circulation Society,Vol. 82,No. 6,p. 1640-1650,2018年,研究論文(学術雑誌)
  • The immune response to prevotella bacteria in autoimmune diseases,Takuro Nii,Yuichi Maeda,Kiyoshi Takeda,Japanese Journal of Allergology,Japanese Society of Allergology,Vol. 67,No. 1,p. 24-27,2018年,研究論文(学術雑誌)
  • GPR31-dependent dendrite protrusion of intestinal CX3CR1+ cells by bacterial metabolites.,竹田 潔,nature,Vol. 566,p. 110-114,2018年
  • The Xenobiotic Transporter Mdr1 Enforces T Cell Homeostasis in the Presence of Intestinal Bile Acids,Wei Cao,Hisako Kayama,Mei Lan Chen,Amber Delmas,Amy Sun,Sang Yong Kim,Erumbi S. Rangarajan,Kelly McKevitt,Amanda P. Beck,Cody B. Jackson,Gogce Crynen,Angelos Oikonomopoulos,Precious N. Lacey,Gustavo J. Martinez,Tina Izard,Robin G. Lorenz,Alex Rodriguez-Palacios,Fabio Cominelli,Maria T. Abreu,Daniel W. Hommes,Sergei B. Koralov,Kiyoshi Takeda,Mark S. Sundrud,Immunity,Cell Press,Vol. 47,No. 6,p. 1182-1196.e10,2017年12月19日,研究論文(学術雑誌)
  • The activated conformation of integrin β7 is a novel multiple myeloma-specific target for CAR T cell therapy.,Naoki Hosen,Yukiko Matsunaga,Kana Hasegawa,Hiroshi Matsuno,Yuki Nakamura,Mio Makita,Kouki Watanabe,Mikako Yoshida,Kei Satoh,Soyoko Morimoto,Fumihiro Fujiki,Hiroko Nakajima,Jun Nakata,Sumiyuki Nishida,Akihiro Tsuboi,Yoshihiro Oka,Masahiro Manabe,Hiroyoshi Ichihara,Yasutaka Aoyama,Atsuko Mugitani,Takafumi Nakao,Masayuki Hino,Ryosuke Uchibori,Keiya Ozawa,Yoshihiro Baba,Seitaro Terakura,Naoki Wada,Eiichi Morii,Junichi Nishimura,Kiyoshi Takeda,Yusuke Oji,Haruo Sugiyama,Junichi Takagi,Atsushi Kumanogoh,Nature medicine,Vol. 23,No. 12,p. 1436-1443,2017年12月,研究論文(学術雑誌)
  • Slc3a2 Mediates Branched-Chain Amino-Acid-Dependent Maintenance of Regulatory T Cells,Kayo Ikeda,Makoto Kinoshita,Hisako Kayama,Shushi Nagamori,Pornparn Kongpracha,Eiji Umemoto,Ryu Okumura,Takashi Kurakawa,Mari Murakami,Norihisa Mikami,Yasunori Shintani,Satoko Ueno,Ayatoshi Andou,Morihiro Ito,Hideki Tsumura,Koji Yasutomo,Keiichi Ozono,Seiji Takashima,Shimon Sakaguchi,Yoshikatsu Kanai,Kiyoshi Takeda,CELL REPORTS,CELL PRESS,Vol. 21,No. 7,p. 1824-1838,2017年11月,研究論文(学術雑誌)
  • CD103(+) Dendritic Cell Function Is Altered in the Colons of Patients with Ulcerative Colitis,Hiroshi Matsuno,Hisako Kayama,Junichi Nishimura,Yuki Sekido,Hideki Osawa,Soumik Barman,Takayuki Ogino,Hidekazu Takahashi,Naotsugu Haraguchi,Taishi Hata,Chu Matsuda,Hirofumi Yamamoto,Motoi Uchino,Hiroki Ikeuchi,Yuichiro Doki,Masaki Mori,Kiyoshi Takeda,Tsunekazu Mizushima,INFLAMMATORY BOWEL DISEASES,LIPPINCOTT WILLIAMS & WILKINS,Vol. 23,No. 9,p. 1524-1534,2017年09月,研究論文(学術雑誌)
  • Role of Gut Microbiota in Rheumatoid Arthritis.,Yuichi Maeda,Kiyoshi Takeda,Journal of clinical medicine,Vol. 6,No. 6,2017年06月09日,研究論文(学術雑誌)
  • BATF2 inhibits immunopathological Th17 responses by suppressing Il23a expression during Trypanosoma cruzi infection,Shoko Kitada,Hisako Kayama,Daisuke Okuzaki,Ritsuko Koga,Masao Kobayashi,Yasunobu Arima,Atsushi Kumanogoh,Masaaki Murakami,Masahito Ikawa,Kiyoshi Takeda,JOURNAL OF EXPERIMENTAL MEDICINE,ROCKEFELLER UNIV PRESS,Vol. 214,No. 5,p. 1313-1331,2017年05月,研究論文(学術雑誌)
  • Regulation of intestinal homeostasis by the ulcerative colitis-associated gene RNF186,Kosuke Fujimoto,Makoto Kinoshita,Hiroo Tanaka,Daisuke Okuzaki,Yosuke Shimada,Hisako Kayama,Ryu Okumura,Yoki Furuta,Masashi Narazaki,Atsushi Tamura,Shigetsugu Hatakeyama,Masahito Ikawa,Kiichiro Tsuchiya,Mamoru Watanabe,Atsushi Kumanogoh,Sachiko Tsukita,Kiyoshi Takeda,MUCOSAL IMMUNOLOGY,NATURE PUBLISHING GROUP,Vol. 10,No. 2,p. 446-459,2017年03月,研究論文(学術雑誌)
  • Regulation of intestinal homeostasis by the ulcerative colitis-associated gene RNF186.,Kosuke Fujimoto,Makoto Kinoshita,Hiroo Tanaka,Daisuke Okuzaki,Yosuke Shimada,Hisako Kayama,Ryu Okumura,Yoki Furuta,Masashi Narazaki,Atsushi Tamura,Shigetsugu Hatakeyama,Masahito Ikawa,Kiichiro Tsuchiya,Mamoru Watanabe,Atsushi Kumanogoh,Sachiko Tsukita,Kiyoshi Takeda,Mucosal Immunol,Vol. 10,No. 2,p. 446-459,2017年03月,研究論文(学術雑誌)
  • Fungal ITS1 deep-sequencing strategies to reconstruct the composition of a 26-species community and evaluation of the gut mycobiota of healthy Japanese individuals,Daisuke Motooka,Kosuke Fujimoto,Reiko Tanaka,Takashi Yaguchi,Kazuyoshi Gotoh,Yuichi Maeda,Yoki Furuta,Takashi Kurakawa,Naohisa Goto,Teruo Yasunaga,Masashi Narazaki,Atsushi Kumanogoh,Toshihiro Horii,Tetsuya Iida,Kiyoshi Takeda,Shota Nakamura,Frontiers in Microbiology,Frontiers Research Foundation,Vol. 8,2017年02月15日,研究論文(学術雑誌)
  • E-NPP3 controls plasmacytoid dendritic cell numbers in the small intestine,Yoki Furuta,Shih-Han Tsai,Makoto Kinoshita,Kosuke Fujimoto,Ryu Okumura,Eiji Umemoto,Yosuke Kurashima,Hiroshi Kiyono,Hisako Kayama,Kiyoshi Takeda,PLOS ONE,PUBLIC LIBRARY SCIENCE,Vol. 12,No. 2,2017年02月,研究論文(学術雑誌)
  • Human LYPD8 protein inhibits motility of flagellated bacteria.,Chiao-Ching Hsu,Ryu Okumura,Kiyoshi Takeda,Inflammation and regeneration,Vol. 37,p. 23-23,2017年,研究論文(学術雑誌)
  • Identification of a human intestinal myeloid cell subset that regulates gut homeostasis,Soumik Barman,Hisako Kayama,Daisuke Okuzaki,Takayuki Ogino,Hideki Osawa,Hiroshi Matsuno,Tsunekazu Mizushima,Masaki Mori,Junichi Nishimura,Kiyoshi Takeda,INTERNATIONAL IMMUNOLOGY,OXFORD UNIV PRESS,Vol. 28,No. 11,p. 533-545,2016年11月,研究論文(学術雑誌)
  • Dysbiosis Contributes to Arthritis Development via Activation of Autoreactive T Cells in the Intestine,Yuichi Maeda,Takashi Kurakawa,Eiji Umemoto,Daisuke Motooka,Yoshinaga Ito,Kazuyoshi Gotoh,Keiji Hirota,Masato Matsushita,Yoki Furuta,Masashi Narazaki,Noriko Sakaguchi,Hisako Kayama,Shota Nakamura,Tetsuya Iida,Yukihiko Saeki,Atsushi Kumanogoh,Shimon Sakaguchi,Kiyoshi Takeda,ARTHRITIS & RHEUMATOLOGY,WILEY,Vol. 68,No. 11,p. 2646-2661,2016年11月,研究論文(学術雑誌)
  • Cutting Edge: Toll-like receptor 4 (TLR4)-Deficient Mice Are hyporesponsive to lipopolysaccharide: Evidence for TLR4 as the Lps gene product,Katsuaki Hoshino,Osamu Takeuchi,Taro Kawai,Hideki Sanjo,Tomohiko Ogawa,Yoshifumi Takeda,Kiyoshi Takeda,Shizuo Akira,Journal of Immunology,Vol. 197,No. 7,p. 2563-2566,2016年10月01日,研究論文(学術雑誌)
  • IL-10-producing lung interstitial macrophages prevent neutrophilic asthma,Hideo Kawano,Hisako Kayama,Takekuni Nakama,Takashi Hashimoto,Eiji Umemoto,Kiyoshi Takeda,INTERNATIONAL IMMUNOLOGY,OXFORD UNIV PRESS,Vol. 28,No. 10,p. 489-501,2016年10月,研究論文(学術雑誌)
  • An improved method for high quality metagenomics DNA extraction from human and environmental samples,Satyabrata Bag,Bipasa Saha,Ojasvi Mehta,D. Anbumani,Naveen Kumar,Mayanka Dayal,Archana Pant,Pawan Kumar,Shruti Saxena,Kristine H. Allin,Torben Hansen,Manimozhiyan Arumugam,Henrik Vestergaard,Oluf Pedersen,Verima Pereira,Philip Abraham,Reva Tripathi,Nitya Wadhwa,Shinjini Bhatnagar,Visvanathan Gnana Prakash,Venkatesan Radha,R. M. Anjana,V. Mohan,Kiyoshi Takeda,Takashi Kurakawa,G. Balakrish Nair,Bhabatosh Das,Scientific Reports,Nature Publishing Group,Vol. 6,2016年05月31日,研究論文(学術雑誌)
  • Lypd8 promotes the segregation of flagellated microbiota and colonic epithelia,Ryu Okumura,Takashi Kurakawa,Takashi Nakano,Hisako Kayama,Makoto Kinoshita,Daisuke Motooka,Kazuyoshi Gotoh,Taishi Kimura,Naganori Kamiyama,Takashi Kusu,Yoshiyasu Ueda,Hong Wu,Hideki Iijima,Soumik Barman,Hideki Osawa,Hiroshi Matsuno,Junichi Nishimura,Yusuke Ohba,Shota Nakamura,Tetsuya Iida,Masahiro Yamamoto,Eiji Umemoto,Koichi Sano,Kiyoshi Takeda,NATURE,NATURE PUBLISHING GROUP,Vol. 532,No. 7597,p. 117-+,2016年04月,研究論文(学術雑誌)
  • Fibroblastic reticular cell-derived lysophosphatidic acid regulates confined intranodal T-cell motility,Akira Takeda,Daichi Kobayashi,Keita Aoi,Naoko Sasaki,Yuki Sugiura,Hidemitsu Igarashi,Kazuo Tohya,Asuka Inoue,Erina Hata,Noriyuki Akahoshi,Haruko Hayasaka,Junichi Kikuta,Elke Scandella,Burkhard Ludewig,Satoshi Ishii,Junken Aoki,Makoto Suematsu,Masaru Ishii,Kiyoshi Takeda,Sirpa Jalkanen,Masayuki Miyasaka,Eiji Umemoto,eLife,eLife Sciences Publications Ltd,Vol. 5,No. 2016,2016年02月02日,研究論文(学術雑誌)
  • Regulation of the human gut homeostasis by anti-inflammatory CD14+ CD163high CD160high myeloid cells,Hisako Kayama,Kiyoshi Takeda,Japanese Journal of Clinical Immunology,Japan Society for Clinical Immunology,Vol. 39,No. 5,p. 441-447,2016年,研究論文(学術雑誌)
  • Altered composition of gut microbiota in rheumatoid arthritis patients,Yuichi Maeda,Atsushi Kumanogoh,Kiyoshi Takeda,Japanese Journal of Clinical Immunology,Japan Society for Clinical Immunology,Vol. 39,No. 1,p. 59-63,2016年,研究論文(学術雑誌)
  • Wnt5a-Ror2シグナルによる腸管炎症の増悪機構の解析,佐藤 朗,香山 尚子,庄嶋 健作,松本 真司,小山 浩史,南 康博,野島 聡,森井 英一,本田 浩章,竹田 潔,菊池 章,日本生化学会大会・日本分子生物学会年会合同大会講演要旨集,(公社)日本生化学会,Vol. 88回・38回,p. [1P0170]-[1P0170],2015年12月
  • RabGDIα is a negative regulator of interferon-γ-inducible GTPase-dependent cell-autonomous immunity to Toxoplasma gondii,Jun Ohshima,Miwa Sasai,Jianfa Liu,Kazuo Yamashita,Ji Su Ma,Youngae Lee,Hironori Bando,Jonathan C. Howard,Shigeyuki Ebisu,Mikako Hayashi,Kiyoshi Takeda,Daron M. Standley,Eva-Maria Frickel,Masahiro Yamamoto,Proceedings of the National Academy of Sciences of the United States of America,National Academy of Sciences,Vol. 112,No. 33,p. E4581-E4590,2015年08月18日,研究論文(学術雑誌)
  • The aryl hydrocarbon receptor/microRNA-212/132 axis in T cells regulates IL-10 production to maintain intestinal homeostasis,Ichino Chinen,Taisuke Nakahama,Akihiro Kimura,Nam T. Nguyen,Hiroshi Takemori,Ayako Kumagai,Hisako Kayama,Kiyoshi Takeda,Soyoung Lee,Hamza Hanieh,Barry Ripley,David Millrine,Praveen K. Dubey,Kishan K. Nyati,Yoshiaki Fujii-Kuriyama,Kamal Chowdhury,Tadamitsu Kishimoto,INTERNATIONAL IMMUNOLOGY,OXFORD UNIV PRESS,Vol. 27,No. 8,p. 405-415,2015年08月,研究論文(学術雑誌)
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  • Smad2 and Smad3 Inversely Regulate TGF-β Autoinduction in Clostridium butyricum-Activated Dendritic Cells,Ikkou Kashiwagi,Rimpei Morita,Takashi Schichita,Kyoko Komai,Keita Saeki,Makoto Matsumoto,Kiyoshi Takeda,Masatoshi Nomura,Atsushi Hayashi,Takanori Kanai,Akihiko Yoshimura,Immunity,Cell Press,Vol. 43,No. 1,p. 65-80,2015年07月21日,研究論文(学術雑誌)
  • The Wnt5a-Ror2 axis promotes the signaling circuit between interleukin-12 and interferon-gamma in colitis,Akira Sato,Hisako Kayama,Kensaku Shojima,Shinji Matsumoto,Hirofumi Koyama,Yasuhiro Minami,Satoshi Nojima,Eiichi Morii,Hiroaki Honda,Kiyoshi Takeda,Akira Kikuchi,SCIENTIFIC REPORTS,NATURE PUBLISHING GROUP,Vol. 5,2015年06月,研究論文(学術雑誌)
  • Correction: Stat3 activation is responsible for IL-6-dependent T cell proliferation through preventing apoptosis: generation and characterization of T cell-specific Stat3-deficient mice.,Kiyoshi Takeda,Tsuneyasu Kaisho,Nobuaki Yoshida,Junji Takeda,Tadamitsu Kishimoto,Shizuo Akira,Journal of immunology (Baltimore, Md. : 1950),Vol. 194,No. 7,p. 3526-3526,2015年04月01日
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  • The Ectoenzyme E-NPP3 Negatively Regulates ATP-Dependent Chronic Allergic Responses by Basophils and Mast Cells,Shih Han Tsai,Makoto Kinoshita,Takashi Kusu,Hisako Kayama,Ryu Okumura,Kayo Ikeda,Yosuke Shimada,Akira Takeda,Soichiro Yoshikawa,Kazushige Obata-Ninomiya,Yosuke Kurashima,Shintaro Sato,Eiji Umemoto,Hiroshi Kiyono,Hajime Karasuyama,Kiyoshi Takeda,IMMUNITY,CELL PRESS,Vol. 42,No. 2,p. 279-293,2015年02月,研究論文(学術雑誌)
  • Regulation of intestinal inflammation through interaction of intestinal environmental factors and innate immune cells,Kayama Hisako,Takeda Kiyoshi,Inflammation and Regeneration,The Japanese Society of Inflammation and Regeneration,Vol. 35,No. 1,p. 28-41,2015年
  • Toll-Like receptors,Kiyoshi Takeda,Shizuo Akira,Current Protocols in Immunology,Blackwell Publishing Inc.,Vol. 2015,p. 14.12.1-14.12.10,2015年,研究論文(学術雑誌)
  • Interleukin-10-Producing Plasmablasts Exert Regulatory Function in Autoimmune Inflammation,Masanori Matsumoto,Akemi Baba,Takafumi Yokota,Hiroyoshi Nishikawa,Yasuyuki Ohkawa,Hisako Kayama,Axel Kallies,Stephen L. Nutt,Shimon Sakaguchi,Kiyoshi Takeda,Tomohiro Kurosaki,Yoshihiro Baba,IMMUNITY,CELL PRESS,Vol. 41,No. 6,p. 1040-1051,2014年12月,研究論文(学術雑誌)
  • The nuclear IκB family protein IκBNS influences the susceptibility to experimental autoimmune encephalomyelitis in a murine model,Shuhei Kobayashi,Akira Hara,Takayuki Isagawa,Ichiro Manabe,Kiyoshi Takeda,Takashi MaruYama,PLoS ONE,Public Library of Science,Vol. 9,No. 10,2014年10月27日,研究論文(学術雑誌)
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  • Selective and strain-specific NFAT4 activation by the Toxoplasma gondii polymorphic dense granule protein GRA6,Ji Su Ma,Miwa Sasai,Jun Ohshima,Youngae Lee,Hironori Bando,Kiyoshi Takeda,Masahiro Yamamoto,Journal of Experimental Medicine,Rockefeller University Press,Vol. 211,No. 10,p. 2013-2032,2014年,研究論文(学術雑誌)
  • Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPases,Etienne Meunier,Mathias S. Dick,Roland F. Dreier,Nura Schürmann,Daniela Kenzelmann Broz,Søren Warming,Merone Roose-Girma,Dirk Bumann,Nobuhiko Kayagaki,Kiyoshi Takeda,Masahiro Yamamoto,Petr Broz,Nature,Nature Publishing Group,Vol. 509,No. 7500,p. 366-370,2014年,研究論文(学術雑誌)
  • A viral RNA structural element alters host recognition of nonself RNA,Jennifer L. Hyde,Christina L. Gardner,Taishi Kimura,James P. White,Gai Liu,Derek W. Trobaugh,Cheng Huang,Marco Tonelli,Slobodan Paessler,Kiyoshi Takeda,William B. Klimstra,Gaya K. Amarasinghe,Michael S. Diamond,Science,American Association for the Advancement of Science,Vol. 343,No. 6172,p. 783-787,2014年,研究論文(学術雑誌)
  • Combination of Tumor Necrosis Factor alpha and Interleukin-6 Induces Mouse Osteoclast-like Cells With Bone Resorption Activity Both In Vitro and In Vivo,Kazuhiro Yokota,Kojiro Sato,Takashi Miyazaki,Hideki Kitaura,Hisako Kayama,Fumihiko Miyoshi,Yasuto Araki,Yuji Akiyama,Kiyoshi Takeda,Toshihide Mimura,ARTHRITIS & RHEUMATOLOGY,WILEY-BLACKWELL,Vol. 66,No. 1,p. 121-129,2014年01月,研究論文(学術雑誌)
  • Increased Th17-Inducing Activity of CD14(+) CD163(low) Myeloid Cells in Intestinal Lamina Propria of Patients With Crohn's Disease,Takayuki Ogino,Junichi Nishimura,Soumik Barman,Hisako Kayama,Satoshi Uematsu,Daisuke Okuzaki,Hideki Osawa,Naotsugu Haraguchi,Mamoru Uemura,Taishi Hata,Ichiro Takemasa,Tsunekazu Mizushima,Hirofumi Yamamoto,Kiyoshi Takeda,Yuichiro Doki,Masaki Mori,GASTROENTEROLOGY,W B SAUNDERS CO-ELSEVIER INC,Vol. 145,No. 6,p. 1380-+,2013年12月,研究論文(学術雑誌)
  • Commensal Bacteria-Dependent Indole Production Enhances Epithelial Barrier Function in the Colon,Yosuke Shimada,Makoto Kinoshita,Kazuo Harada,Masafumi Mizutani,Kazunori Masahata,Hisako Kayama,Kiyoshi Takeda,PLOS ONE,PUBLIC LIBRARY SCIENCE,Vol. 8,No. 11,2013年11月,研究論文(学術雑誌)
  • Ifit1 Inhibits Japanese Encephalitis Virus Replication through Binding to 5 ' Capped 2 '-O Unmethylated RNA,Taishi Kimura,Hiroshi Katoh,Hisako Kayama,Hiroyuki Saiga,Megumi Okuyama,Toru Okamoto,Eiji Umemoto,Yoshiharu Matsuura,Masahiro Yamamoto,Kiyoshi Takeda,JOURNAL OF VIROLOGY,AMER SOC MICROBIOLOGY,Vol. 87,No. 18,p. 9997-10003,2013年09月,研究論文(学術雑誌)
  • CREBH Determines the Severity of Sulpyrine-Induced Fatal Shock,Naganori Kamiyama,Masahiro Yamamoto,Hiroyuki Saiga,Ji Su Ma,Jun Ohshima,Sakaaki Machimura,Miwa Sasai,Taishi Kimura,Yoshiyasu Ueda,Hisako Kayama,Kiyoshi Takeda,PLoS ONE,Vol. 8,No. 2,2013年02月07日,研究論文(学術雑誌)
  • Microbe-dependent CD11b+ IgA+ plasma cells mediate robust early-phase intestinal IgA responses in mice,Jun Kunisawa,Masashi Gohda,Eri Hashimoto,Izumi Ishikawa,Morio Higuchi,Yuji Suzuki,Yoshiyuki Goto,Casandra Panea,Ivaylo I. Ivanov,Risa Sumiya,Lamichhane Aayam,Taichi Wake,So Tajiri,Yosuke Kurashima,Shiori Shikata,Shizuo Akira,Kiyoshi Takeda,Hiroshi Kiyono,Nature Communications,Vol. 4,2013年,研究論文(学術雑誌)
  • Ecto-Nucleoside Triphosphate Diphosphohydrolase 7 Controls Th17 Cell Responses through Regulation of Luminal ATP in the Small Intestine,Takashi Kusu,Hisako Kayama,Makoto Kinoshita,Seong Gyu Jeon,Yoshiyasu Ueda,Yoshiyuki Goto,Ryu Okumura,Hiroyuki Saiga,Takashi Kurakawa,Kayo Ikeda,Yuichi Maeda,Jun-ichi Nishimura,Yasunobu Arima,Koji Atarashi,Kenya Honda,Masaaki Murakami,Jun Kunisawa,Hiroshi Kiyono,Meinoshin Okumura,Masahiro Yamamoto,Kiyoshi Takeda,JOURNAL OF IMMUNOLOGY,AMER ASSOC IMMUNOLOGISTS,Vol. 190,No. 2,p. 774-783,2013年01月,研究論文(学術雑誌)
  • Pancreatic STAT3 protects mice against caerulein-induced pancreatitis via PAP1 induction,Minoru Shigekawa,Hayato Hikita,Takahiro Kodama,Satoshi Shimizu,Wei Li,Akio Uemura,Takuya Miyagi,Atsushi Hosui,Tatsuya Kanto,Naoki Hiramatsu,Tomohide Tatsumi,Kiyoshi Takeda,Shizuo Akira,Tetsuo Takehara,American Journal of Pathology,Vol. 181,No. 6,p. 2105-2113,2012年12月,研究論文(学術雑誌)
  • Critical role of AIM2 in Mycobacterium tuberculosis infection,Hiroyuki Saiga,Shoko Kitada,Yosuke Shimada,Naganori Kamiyama,Megumi Okuyama,Masahiko Makino,Masahiro Yamamoto,Kiyoshi Takeda,International Immunology,Vol. 24,No. 10,p. 637-644,2012年10月,研究論文(学術雑誌)
  • Dietary Folic Acid Promotes Survival of Foxp3(+) Regulatory T Cells in the Colon,Makoto Kinoshita,Hisako Kayama,Takashi Kusu,Tomoyuki Yamaguchi,Jun Kunisawa,Hiroshi Kiyono,Shimon Sakaguchi,Kiyoshi Takeda,JOURNAL OF IMMUNOLOGY,AMER ASSOC IMMUNOLOGISTS,Vol. 189,No. 6,p. 2869-2878,2012年09月,研究論文(学術雑誌)
  • Systems biology approaches to toll-like receptor signaling,Alexis Vandenbon,Shunsuke Teraguchi,Shizuo Akira,Kiyoshi Takeda,Daron M. Standley,WILEY INTERDISCIPLINARY REVIEWS-SYSTEMS BIOLOGY AND MEDICINE,WILEY,Vol. 4,No. 5,p. 497-507,2012年09月,研究論文(学術雑誌)
  • Dynamism of immune reactions and regulation.,Tomohiro Kurosaki,Takashi Saito,Atsushi Kumanogoh,Kiyoshi Takeda,Tsuneyasu Kaisho,International immunology,Vol. 24,No. 8,p. 473-5,2012年08月
  • A Cluster of Interferon-gamma-Inducible p65 GTPases Plays a Critical Role in Host Defense against Toxoplasma gondii,Masahiro Yamamoto,Megumi Okuyama,Ji Su Ma,Taishi Kimura,Naganori Kamiyama,Hiroyuki Saiga,Jun Ohshima,Miwa Sasai,Hisako Kayama,Toru Okamoto,David C. S. Huang,Dominique Soldati-Favre,Kyoji Horie,Junji Takeda,Kiyoshi Takeda,IMMUNITY,CELL PRESS,Vol. 37,No. 2,p. 302-313,2012年08月,研究論文(学術雑誌)
  • FCMで免疫疾患を追い詰める 細胞外ATPによるマウス腸管固有粘膜層におけるTh17細胞誘導,西村 潤一,竹田 潔,植村 守,竹政 伊知朗,水島 恒和,池田 政孝,石井 秀始,山本 浩文,関本 貢嗣,土岐 祐一郎,森 政樹,Cytometry Research,(一社)日本サイトメトリー学会,Vol. 22,No. Suppl.,p. 41-41,2012年06月
  • Probiotic Bifidobacterium breve Induces IL-10-Producing Tr1 Cells in the Colon,Seong Gyu Jeon,Hisako Kayama,Yoshiyasu Ueda,Takuya Takahashi,Takashi Asahara,Hirokazu Tsuji,Noriko M. Tsuji,Hiroshi Kiyono,Ji Su Ma,Takashi Kusu,Ryu Okumura,Hiromitsu Hara,Hiroki Yoshida,Masahiro Yamamoto,Koji Nomoto,Kiyoshi Takeda,PLOS PATHOGENS,PUBLIC LIBRARY SCIENCE,Vol. 8,No. 5,2012年05月,研究論文(学術雑誌)
  • Probiotic Bifidobacterium breve induces IL-10-producing Tr1 cells in the colon,Seong Gyu Jeon,Hisako Kayama,Yoshiyasu Ueda,Takuya Takahashi,Takashi Asahara,Hirokazu Tsuji,Noriko M. Tsuji,Hiroshi Kiyono,Ji Su Ma,Takashi Kusu,Ryu Okumura,Hiromitsu Hara,Hiroki Yoshida,Masahiro Yamamoto,Koji Nomoto,Kiyoshi Takeda,PLoS Pathogens,Vol. 8,No. 5,2012年05月,研究論文(学術雑誌)
  • Prophylactic and therapeutic implications of toll-like receptor ligands,Mona Hedayat,Kiyoshi Takeda,Nima Rezaei,Medicinal Research Reviews,Vol. 32,No. 2,p. 294-325,2012年03月,研究論文(学術雑誌)
  • Intestinal CX3C chemokine receptor 1(high) (CX(3)CR1(high)) myeloid cells prevent T-cell-dependent colitis,Hisako Kayama,Yoshiyasu Ueda,Yukihisa Sawa,Seong Gyu Jeon,Ji Su Ma,Ryu Okumura,Atsuko Kubo,Masaru Ishii,Taku Okazaki,Masaaki Murakami,Masahiro Yamamoto,Hideo Yagita,Kiyoshi Takeda,PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,NATL ACAD SCIENCES,Vol. 109,No. 13,p. 5010-5015,2012年03月,研究論文(学術雑誌)
  • IκBNS regulates interleukin-6 production and inhibits neointimal formation after vascular injury in mice,Tomiharu Niida,Kikuo Isoda,Manabu Kitagaki,Norio Ishigami,Takeshi Adachi,Osamu Matsubara,Kiyoshi Takeda,Tadamitsu Kishimoto,Fumitaka Ohsuzu,Cardiovascular Research,Vol. 93,No. 2,p. 371-379,2012年02月01日,研究論文(学術雑誌)
  • Innate immunity and inflammatory bowel diseases,Makoto Kinoshita,Kiyoshi Takeda,Japanese Journal of Allergology,Vol. 61,No. 12,p. 1726-1728,2012年,研究論文(学術雑誌)
  • Inhibition of ATF6β-dependent host adaptive immune response by a toxoplasma virulence factor ROP18,Masahiro Yamamoto,Kiyoshi Takeda,Virulence,Taylor and Francis Inc.,Vol. 3,No. 1,p. 77-80,2012年,研究論文(学術雑誌)
  • The Lactic Acid Bacterium Pediococcus acidilactici Suppresses Autoimmune Encephalomyelitis by Inducing IL-10-Producing Regulatory T Cells,Kazushiro Takata,Makoto Kinoshita,Tatsusada Okuno,Masayuki Moriya,Tohru Kohda,Josephe A. Honorat,Tomoyuki Sugimoto,Atsushi Kumanogoh,Hisako Kayama,Kiyoshi Takeda,Saburo Sakoda,Yuji Nakatsuji,PLOS ONE,PUBLIC LIBRARY SCIENCE,Vol. 6,No. 11,2011年11月,研究論文(学術雑誌)
  • Generation of mice deficient in RNA-binding motif protein 3 (RBM3) and characterization of its role in innate immune responses and cell growth,Atsushi Matsuda,Masahiro Ogawa,Hideyuki Yanai,Daiji Naka,Ayana Goto,Tomoka Ao,Yuji Tanno,Kiyoshi Takeda,Yoshinori Watanabe,Kenya Honda,Tadatsugu Taniguchi,Biochemical and Biophysical Research Communications,Vol. 411,No. 1,p. 7-13,2011年07月22日,研究論文(学術雑誌)
  • ATF6β is a host cellular target of the Toxoplasma gondii virulence factor ROP18,Masahiro Yamamoto,Ji Su Ma,Christina Mueller,Naganori Kamiyama,Hiroyuki Saiga,Emi Kubo,Taishi Kimura,Toru Okamoto,Megumi Okuyama,Hisako Kayama,Kisaburo Nagamune,Seiji Takashima,Yoshiharu Matsuura,Dominique Soldati-Favre,Kiyoshi Takeda,Journal of Experimental Medicine,Vol. 208,No. 7,p. 1533-1546,2011年07月04日,研究論文(学術雑誌)
  • Enhanced cancer immunotherapy using STAT3-depleted dendritic cells with high Th1-inducing ability and resistance to cancer cell-derived inhibitory factors,Tomoko Iwata-Kajihara,Hidetoshi Sumimoto,Naoshi Kawamura,Ryo Ueda,Tomomi Takahashi,Hiroyuki Mizuguchi,Makoto Miyagishi,Kiyoshi Takeda,Yutaka Kawakami,Journal of Immunology,Vol. 187,No. 1,p. 27-36,2011年07月01日,研究論文(学術雑誌)
  • Induction of colonic regulatory T cells by indigenous Clostridium species,Koji Atarashi,Takeshi Tanoue,Tatsuichiro Shima,Akemi Imaoka,Tomomi Kuwahara,Yoshika Momose,Genhong Cheng,Sho Yamasaki,Takashi Saito,Yusuke Ohba,Tadatsugu Taniguchi,Kiyoshi Takeda,Shohei Hori,Ivaylo I. Ivanov,Yoshinori Umesaki,Kikuji Itoh,Kenya Honda,Science,American Association for the Advancement of Science,Vol. 331,No. 6015,p. 337-341,2011年01月21日,研究論文(学術雑誌)
  • A method for the generation of conditional gene-targeted mice,Masahiro Yamamoto,Kiyoshi Takeda,Methods in Molecular Biology,Vol. 757,p. 399-410,2011年,研究論文(学術雑誌)
  • Commensal microbiota induce LPS hyporesponsiveness in colonic macrophages via the production of IL-10.,Yoshiyasu Ueda,Hisako Kayama,Seong Gyu Jeon,Takashi Kusu,Yoshitaka Isaka,Hiromi Rakugi,Masahiro Yamamoto,Kiyoshi Takeda,International immunology,Vol. 22,No. 12,p. 953-62,2010年12月,研究論文(学術雑誌)
  • A novel in vivo inducible dendritic cell ablation model in mice,Megumi Okuyama,Hisako Kayama,Koji Atarashi,Hiroyuki Saiga,Taishi Kimura,Ari Waisman,Masahiro Yamamoto,Kiyoshi Takeda,BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,ACADEMIC PRESS INC ELSEVIER SCIENCE,Vol. 397,No. 3,p. 559-563,2010年07月,研究論文(学術雑誌)
  • Potential of novel antimycobacterial immune factors, SLPI and Lipocalin 2,Hiroyuki Saiga,Kiyoshi Takeda,Kekkaku,Vol. 85,No. 6,p. 523-530,2010年06月,研究論文(学術雑誌)
  • Therapeutic activation of signal transducer and activator of transcription 3 by interleukin-11 ameliorates cardiac fibrosis after myocardial infarction,Masanori Obana,Makiko Maeda,Koji Takeda,Akiko Hayama,Tomomi Mohri,Tomomi Yamashita,Yoshikazu Nakaoka,Issei Komuro,Kiyoshi Takeda,Goro Matsumiya,Junichi Azuma,Yasushi Fujio,Circulation,Vol. 121,No. 5,p. 684-691,2010年02月,研究論文(学術雑誌)
  • Activation of myeloid dendritic cells by deoxynucleic acids from Cordyceps sinensis via a Toll-like receptor 9-dependent pathway,Gang Xiao,Akiko Miyazato,Yuzuru Abe,Tiantuo Zhang,Kiwamu Nakamura,Ken Inden,Misuzu Tanaka,Daiki Tanno,Tomomitsu Miyasaka,Keiko Ishii,Kiyoshi Takeda,Shizuo Akira,Shinobu Saijo,Yoichiro Iwakura,Yoshiyuki Adachi,Naohito Ohno,Natsuo Yamamoto,Hiroyuki Kunishima,Yoichi Hirakata,Mitsuo Kaku,Kazuyoshi Kawakami,Cellular Immunology,Vol. 263,No. 2,p. 241-250,2010年,研究論文(学術雑誌)
  • A single polymorphic amino acid on Toxoplasma gondii kinase ROP16 determines the direct and strain-specific activation of Stat3,Masahiro Yamamoto,Daron M. Standley,Seiji Takashima,Hiroyuki Saiga,Megumi Okuyama,Hisako Kayama,Emi Kubo,Hiroshi Ito,Mutsumi Takaura,Tadashi Matsuda,Dominique Soldati-Favre,Kiyoshi Takeda,Journal of Experimental Medicine,Vol. 206,No. 12,p. 2747-2760,2009年11月23日,研究論文(学術雑誌)
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  • Toll-like receptor 9-dependent activation of myeloid dendritic cells by deoxynucleic acids from Candida albicans,Akiko Miyazato,Kiwamu Nakamura,Natsuo Yamamoto,Héctor M. Mora-Montes,Misuzu Tanaka,Yuzuru Abe,Daiki Tanno,Ken Inden,Xiao Gang,Keiko Ishii,Kiyoshi Takeda,Shizuo Akira,Shinobu Saijo,Yoichiro Iwakura,Yoshiyuki Adachi,Naohito Ohno,Kotaro Mitsutake,Neil A. R. Gow,Mitsuo Kaku,Kazuyoshi Kawakami,Infection and Immunity,Vol. 77,No. 7,p. 3056-3064,2009年07月,研究論文(学術雑誌)
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  • Fra-1 negatively regulates lipopolysaccharide-mediated inflammatory responses.,Hideaki Morishita,Fumiji Saito,Hisako Kayama,Koji Atarashi,Hirotaka Kuwata,Masahiro Yamamoto,Kiyoshi Takeda,International immunology,4,Vol. 21,No. 4,p. 457-65,2009年04月,研究論文(学術雑誌)
  • C-type lectin Mincle is an activating receptor for pathogenic fungus, Malassezia,Sho Yamasaki,Makoto Matsumoto,Osamu Takeuchi,Tetsuhiro Matsuzawa,Eri Ishikawa,Machie Sakuma,Hiroaki Tateno,Jun Uno,Jun Hirabayashi,Yuzuru Mikami,Kiyoshi Takeda,Shizuo Akira,Takashi Saito,Proceedings of the National Academy of Sciences of the United States of America,Vol. 106,No. 6,p. 1897-1902,2009年02月10日,研究論文(学術雑誌)
  • The survival pathways phosphatidylinositol-3 kinase (PI3-K)/phosphoinositide-dependent protein kinase 1 (PDK1)/Akt modulate liver regeneration through hepatocyte size rather than proliferation,Sanae Haga,Michitaka Ozaki,Hiroshi Inoue,Yasuo Okamoto,Wataru Ogawa,Kiyoshi Takeda,Shizuo Akira,Satoru Todo,Hepatology,Vol. 49,No. 1,p. 204-214,2009年,研究論文(学術雑誌)
  • Lipocalin 2-dependent inhibition of mycobacterial growth in alveolar epithelium,Hiroyuki Saiga,Junichi Nishimura,Hirotaka Kuwata,Megumi Okuyama,Sohkichi Matsumoto,Shintaro Sato,Makoto Matsumoto,Shizuo Akira,Yasunobu Yoshikai,Kenya Honda,Masahiro Yamamoto,Kiyoshi Takeda,Journal of Immunology,American Association of Immunologists,Vol. 181,No. 12,p. 8521-8527,2008年12月15日,研究論文(学術雑誌)
  • Inefficient phagosome maturation in infant macrophages,Fumiji Saito,Hirotaka Kuwata,Eiji Oiki,Masato Koike,Yasuo Uchiyama,Kenya Honda,Kiyoshi Takeda,Biochemical and Biophysical Research Communications,Vol. 375,No. 1,p. 113-118,2008年10月10日,研究論文(学術雑誌)
  • ATP drives lamina propria T(H)17 cell differentiation.,Koji Atarashi,Junichi Nishimura,Tatsuichiro Shima,Yoshinori Umesaki,Masahiro Yamamoto,Masaharu Onoue,Hideo Yagita,Naoto Ishii,Richard Evans,Kenya Honda,Kiyoshi Takeda,Nature,Vol. 455,No. 7214,p. 808-12,2008年10月09日,研究論文(学術雑誌)
  • Targeted disruption of Hsp110/105 gene protects against ischemic stress,Junji Nakamura,Motoaki Fujimoto,Kunihiko Yasuda,Kiyoshi Takeda,Shizuo Akira,Takumi Hatayama,Yasushi Takagi,Kazuhiko Nozaki,Nobuko Hosokawa,Kazuhiro Nagata,Stroke,Vol. 39,No. 10,p. 2853-2859,2008年10月01日,研究論文(学術雑誌)
  • Toll-like receptor 2 (TLR2) and dectin-1 contribute to the production of IL-12p40 by bone marrow-derived dendritic cells infected with Penicillium marneffei,Kiwamu Nakamura,Akiko Miyazato,Yoshinobu Koguchi,Yoshiyuki Adachi,Naohito Ohno,Shinobu Saijo,Yoichiro Iwakura,Kiyoshi Takeda,Shizuo Akira,Jiro Fujita,Keiko Ishii,Mitsuo Kaku,Kazuyoshi Kawakami,Microbes and Infection,Vol. 10,No. 10-11,p. 1223-1227,2008年08月,研究論文(学術雑誌)
  • Stat6-independent tissue inflammation occurs selectively on the ocular surface and perioral skin of I kappa B zeta(-/-) Mice,Mayumi Ueta,Junji Hamuro,Eiichiro Ueda,Norito Katoh,Masahiro Yamamoto,Kiyoshi Takeda,Shizuo Akira,Shigeru Kinoshita,INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE,ASSOC RESEARCH VISION OPHTHALMOLOGY INC,Vol. 49,No. 8,p. 3387-3394,2008年08月,研究論文(学術雑誌)
  • STAT3 is a critical regulator of astrogliosis and scar formation after spinal cord injury,Julia E. Herrmann,Tetsuya Imura,Bingbing Song,Jingwei Qi,Yan Ao,Thu K. Nguyen,Rose A. Korsak,Kiyoshi Takeda,Shizuo Akira,Michael V. Sofroniew,Journal of Neuroscience,Vol. 28,No. 28,p. 7231-7243,2008年07月09日,研究論文(学術雑誌)
  • Signal transducer and activator of transcription-3 is required in hypothalamic agouti-related protein/neuropeptide Y neurons for normal energy homeostasis,Lijie Gong,Fayi Yao,Kristin Hockman,Henry H. Heng,Gregory J. Morton,Kiyoshi Takeda,Shizuo Akira,Malcolm J. Low,Marcelo Rubinstein,Robert G. MacKenzie,Endocrinology,Vol. 149,No. 7,p. 3346-3354,2008年07月,研究論文(学術雑誌)
  • Class-specific regulation of pro-inflammatory genes by MyD88 pathways and I kappa B zeta,Hisako Kayama,Vladimir R. Ramirez-Carrozzi,Masahiro Yamamoto,Taketoshi Mizutani,Hirotaka Kuwata,Hideo Iba,Makoto Matsumoto,Kenya Honda,Stephen T. Smale,Kiyoshi Takeda,JOURNAL OF BIOLOGICAL CHEMISTRY,AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC,Vol. 283,No. 18,p. 12468-12477,2008年05月,研究論文(学術雑誌)
  • Deoxynucleic acids from Cryptococcus neoformans activate myeloid dendritic cells via a TLR9-dependent pathway,Kiwamu Nakamura,Akiko Miyazato,Gang Xiao,Masumitsu Hatta,Ken Inden,Tetsuji Aoyagi,Kohei Shiratori,Kiyoshi Takeda,Shizuo Akira,Shinobu Saijo,Yoichiro Iwakura,Yoshiyuki Adachi,Naohito Ohno,Kazuo Suzuki,Jiro Fujita,Mitsuo Kaku,Kazuyoshi Kawakami,Journal of Immunology,American Association of Immunologists,Vol. 180,No. 6,p. 4067-4074,2008年03月15日,研究論文(学術雑誌)
  • Potent antimycobacterial activity of mouse secretory leukocyte protease inhibitor,Junichi Nishimura,Hiroyuki Saiga,Shintaro Sato,Megumi Okuyama,Hisako Kayama,Hirotaka Kuwata,Sohkichi Matsumoto,Toshirou Nishida,Yoshiki Sawa,Shizuo Akira,Yasunobu Yoshikai,Masahiro Yamamoto,Kiyoshi Takeda,Journal of Immunology,American Association of Immunologists,Vol. 180,No. 6,p. 4032-4039,2008年03月15日,研究論文(学術雑誌)
  • STAT3 is indispensable to IL-27-mediated cell proliferation but not to IL-27-induced Th1 differentiation and suppression of proinflammatory cytokine production,Toshiyuki Owaki,Masayuki Asakawa,Noriko Morishima,Izuru Mizoguchi,Fumio Fukai,Kiyoshi Takeda,Junichiro Mizuguchi,Takayuki Yoshimoto,Journal of Immunology,American Association of Immunologists,Vol. 180,No. 5,p. 2903-2911,2008年03月01日,研究論文(学術雑誌)
  • Malaria parasites require TLR9 signaling for immune evasion by activating regulatory T cells,Hajime Hisaeda,Kohhei Tetsutani,Takashi Imai,Chikako Moriya,Liping Tu,Shinjiro Hamano,Xuefeng Duan,Bin Chou,Hidekazu Ishida,Akiko Aramaki,Jianying Shen,Ken J. Ishii,Cevayir Coban,Shizuo Akira,Kiyoshi Takeda,Koji Yasutomo,Motomi Torii,Kunisuke Himeno,Journal of Immunology,American Association of Immunologists,Vol. 180,No. 4,p. 2496-2503,2008年02月15日,研究論文(学術雑誌)
  • Assessing the response of cells to TLR stimulation,Kiyoshi Takeda,Masahiro Yamamoto,Kenya Honda,Signaling by Toll-Like Receptors,p. 1-21,2008年01月01日,論文集(書籍)内論文
  • Signal transducer and activator of transcription 3 signaling within hepatocytes attenuates systemic inflammatory response and lethality in septic mice.,Ryotaro Sakamori,Tetsuo Takehara,Chihiro Ohnishi,Tomohide Tatsumi,Kazuyoshi Ohkawa,Kiyoshi Takeda,Shizuo Akira,Norio Hayashi,Hepatology (Baltimore, Md.),Vol. 46,No. 5,p. 1564-73,2007年11月,研究論文(学術雑誌)
  • Enhanced TLR-mediated NF-IL6-dependent gene expression by Trib1 deficiency,Masahiro Yamamoto,Satoshi Uematsu,Toru Okamoto,Yoshiharu Matsuura,Shintaro Sato,Himanshu Kumar,Takashi Satoh,Tatsuya Saitoh,Kiyoshi Takeda,Ken J. Ishii,Osamu Takeuchi,Taro Kawai,Shizuo Akira,JOURNAL OF EXPERIMENTAL MEDICINE,ROCKEFELLER UNIV PRESS,Vol. 204,No. 9,p. 2233-2239,2007年09月,研究論文(学術雑誌)
  • Bone Marrow Retaining Colitogenic CD4+ T Cells May Be a Pathogenic Reservoir for Chronic Colitis,Yasuhiro Nemoto,Takanori Kanai,Shin Makita,Ryuichi Okamoto,Teruji Totsuka,Kiyoshi Takeda,Mamoru Watanabe,Gastroenterology,Vol. 132,No. 1,p. 176-189,2007年01月,研究論文(学術雑誌)
  • TLR-dependent induction of IFN-beta mediates host defense against Trypanosoma cruzi.,Ritsuko Koga,Shinjiro Hamano,Hirotaka Kuwata,Koji Atarashi,Masahiro Ogawa,Hajime Hisaeda,Masahiro Yamamoto,Shizuo Akira,Kunisuke Himeno,Makoto Matsumoto,Kiyoshi Takeda,Journal of immunology (Baltimore, Md. : 1950),Vol. 177,No. 10,p. 7059-66,2006年11月15日,研究論文(学術雑誌)
  • Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling.,Masahiro Yamamoto,Toru Okamoto,Kiyoshi Takeda,Shintaro Sato,Hideki Sanjo,Satoshi Uematsu,Tatsuya Saitoh,Naoki Yamamoto,Hiroaki Sakurai,Ken J Ishii,Shoji Yamaoka,Taro Kawai,Yoshiharu Matsuura,Osamu Takeuchi,Shizuo Akira,Nature immunology,Vol. 7,No. 9,p. 962-70,2006年09月,研究論文(学術雑誌)
  • Detection of pathogenic intestinal bacteria by Toll-like receptor 5 on intestinal CD11c+ lamina propria cells.,Satoshi Uematsu,Myoung Ho Jang,Nicolas Chevrier,Zijin Guo,Yutaro Kumagai,Masahiro Yamamoto,Hiroki Kato,Nagako Sougawa,Hidenori Matsui,Hirotaka Kuwata,Hiroaki Hemmi,Cevayir Coban,Taro Kawai,Ken J Ishii,Osamu Takeuchi,Masayuki Miyasaka,Kiyoshi Takeda,Shizuo Akira,Nature immunology,Vol. 7,No. 8,p. 868-74,2006年08月,研究論文(学術雑誌)
  • Non-cell-autonomous action of STAT3 in maintenance of neural precursor cells in the mouse neocortex,Takeshi Yoshimatsu,Daichi Kawaguchi,Koji Oishi,Kiyoshi Takeda,Shizuo Akira,Norihisa Masuyama,Yukiko Gotoh,Development,Vol. 133,No. 13,p. 2553-2563,2006年07月,研究論文(学術雑誌)
  • Plexin-A1 and its interaction with DAP12 in immune responses and bone homeostasis,Noriko Takegahara,Hyota Takamatsu,Toshihiko Toyofuku,Tohru Tsujimura,Tatsusada Okuno,Kazunori Yukawa,Masayuki Mizui,Midori Yamamoto,Durbaka V.R. Prasad,Kazuhiro Suzuki,Masaru Ishii,Kenta Terai,Masayuki Moriya,Yuji Nakatsuji,Saburo Sakoda,Shintaro Sato,Shizuo Akira,Kiyoshi Takeda,Masanori Inui,Toshiyuki Takai,Masahito Ikawa,Masaru Okabe,Atsushi Kumanogoh,Hitoshi Kikutani,Nature Cell Biology,Vol. 8,No. 6,p. 615-622,2006年06月,研究論文(学術雑誌)
  • Persistent expression of PDX-1 in the pancreas causes acinar-to-ductal metaplasia through Stat3 activation,Takeshi Miyatsuka,Hideaki Kaneto,Toshihiko Shiraiwa,Taka-Aki Matsuoka,Kaoru Yamamoto,Ken Kato,Yumiko Nakamura,Shizuo Akira,Kiyoshi Takeda,Yoshitaka Kajimoto,Yoshimitsu Yamasaki,Eric P. Sandgren,Yoshiya Kawaguchi,Christopher V. E. Wright,Yoshio Fujitani,Genes and Development,Vol. 20,No. 11,p. 1435-1440,2006年06月01日,研究論文(学術雑誌)
  • Limited contribution of Toll-like receptor 2 and 4 to the host response to a fungal infectious pathogen, Cryptococcus neoformans,Kiwamu Nakamura,Kazuya Miyagi,Yoshinobu Koguchi,Yuki Kinjo,Kaori Uezu,Takeshi Kinjo,Morikazu Akamine,Jiro Fujita,Ikuo Kawamura,Masao Mitsuyama,Yoshiyuki Adachi,Naohito Ohno,Kiyoshi Takeda,Shizuo Akira,Akiko Miyazato,Mitsuo Kaku,Kazuyoshi Kawakami,FEMS Immunology and Medical Microbiology,Vol. 47,No. 1,p. 148-154,2006年06月,研究論文(学術雑誌)
  • MyD88-dependent signaling for IL-15 production plays an important role in maintenance of CD8αα TCRαβ and TCRγδ intestinal intraepithelial lymphocytes,Qingsheng Yu,Ce Tang,Sun Xun,Toshiki Yajima,Kiyoshi Takeda,Yasunobu Yoshikai,Journal of Immunology,Vol. 176,No. 10,p. 6180-6185,2006年05月15日,研究論文(学術雑誌)
  • Essential role of IκB kinase α in thymic organogenesis required for the establishment of self-tolerance,Dan Kinoshita,Fumiko Hirota,Tsuneyasu Kaisho,Michiyuki Kasai,Keisuke Izumi,Yoshimi Bando,Yasuhiro Mouri,Akemi Matsushima,Shino Niki,Hongwei Han,Kiyotaka Oshikawa,Noriyuki Kuroda,Masahiko Maegawa,Minoru Irahara,Kiyoshi Takeda,Shizuo Akira,Mitsuru Matsumoto,Journal of Immunology,Vol. 176,No. 7,p. 3995-4002,2006年04月01日,研究論文(学術雑誌)
  • IL-18 is redundant in T-cell responses and in joint inflammation in antigen-induced arthritis,Leilani L. Santos,Georgia P. Milenkovski,Pamela H. Hall,Michelle Leech,Laveena Sharma,Kiyoshi Takeda,Shizuo Akira,A. Richard Kitching,Eric F. Morand,Immunology and Cell Biology,Vol. 84,No. 2,p. 166-173,2006年04月,研究論文(学術雑誌)
  • IL-27 suppresses CD28-medicated IL-2 production through suppressor of cytokine signaling 3,Toshiyuki Owaki,Masayuki Asakawa,Sadahiro Kamiya,Kiyoshi Takeda,Fumio Fukai,Junichiro Mizuguchi,Takayuki Yoshimoto,Journal of Immunology,American Association of Immunologists,Vol. 176,No. 5,p. 2773-2780,2006年03月01日,研究論文(学術雑誌)
  • IkappaBNS inhibits induction of a subset of Toll-like receptor-dependent genes and limits inflammation.,Hirotaka Kuwata,Makoto Matsumoto,Koji Atarashi,Hideaki Morishita,Tomohiro Hirotani,Ritsuko Koga,Kiyoshi Takeda,Immunity,1,Vol. 24,No. 1,p. 41-51,2006年01月,研究論文(学術雑誌)
  • Escherichia coliverotoxin 1 mediates apoptosis in human HCT116 colon cancer cells by inducing overexpression of the GADD family of genes and S phase arrest,Rabindra N. Bhattacharjee,Kwon-Sam Park,Satoshi Uematsu,Kazuhisa Okada,Katsuaki Hoshino,Kiyoshi Takeda,Osamu Takeuchi,Shizuo Akira,Tetsuya Iida,Takeshi Honda,FEBS Letters,Wiley,Vol. 579,No. 29,p. 6604-6610,2005年12月05日,研究論文(学術雑誌)
  • IL-6/IL-12関連サイトカインIL-27の機能発現におけるSTAT3の役割,善本 隆之,大脇 敏之,浅川 正幸,森嶋 紀子,竹田 潔,村上 正晃,平野 敏夫,水口 純一郎,日本免疫学会総会・学術集会記録,(NPO)日本免疫学会,Vol. 35,p. 283-283,2005年11月
  • Essential function for the kinase TAK1 in innate and adaptive immune responses.,Shintaro Sato,Hideki Sanjo,Kiyoshi Takeda,Jun Ninomiya-Tsuji,Masahiro Yamamoto,Taro Kawai,Kunihiro Matsumoto,Osamu Takeuchi,Shizuo Akira,Nature immunology,Vol. 6,No. 11,p. 1087-95,2005年11月,研究論文(学術雑誌)
  • The MyD88-dependent, but not the MyD88-independent, pathway of TLR4 signaling is important in clearing nontypeable Haemophilus influenzae from the mouse lung,Catharina W. Wieland,Sandrine Florquin,Nico A. Maris,Kasper Hoebe,Bruce Beutler,Kiyoshi Takeda,Shizuo Akira,Tom Van Der Poll,Journal of Immunology,American Association of Immunologists,Vol. 175,No. 9,p. 6042-6049,2005年11月01日,研究論文(学術雑誌)
  • Compensatory recovery of liver mass by Akt-mediated hepatocellular hypertrophy in liver-specific STAT3-deficient mice,Sanae Haga,Wataru Ogawa,Hiroshi Inoue,Keita Terui,Tetsuya Ogino,Rumi Igarashi,Kiyoshi Takeda,Shizuo Akira,Shin Enosawa,Hiroyuki Furukawa,Satoru Todo,Michitaka Ozaki,Journal of Hepatology,Vol. 43,No. 5,p. 799-807,2005年11月,研究論文(学術雑誌)
  • Reduced prepulse inhibition of startle in STAT6-deficient mice.,Kazunori Yukawa,Tetsuji Tanaka,Kyoko Owada-Makabe,Yuji Tsubota,Tao Bai,Masanobu Maeda,Kiyoshi Takeda,Shizuo Akira,Hiroyuki Iso,International journal of molecular medicine,Vol. 16,No. 4,p. 673-5,2005年10月,研究論文(学術雑誌)
  • Stat3 in resident macrophages as a repressor protein of inflammatory response,Akihiro Matsukawa,Shinji Kudo,Takako Maeda,Kousuke Numata,Hiroyuki Watanabe,Kiyoshi Takeda,Shizuo Akira,Takaaki Ito,Journal of Immunology,American Association of Immunologists,Vol. 175,No. 5,p. 3354-3359,2005年09月01日,研究論文(学術雑誌)
  • MyD88, but not toll-like receptors 4 and 2, is required for efficient clearance of Brucella abortus,David S. Weiss,Kiyoshi Takeda,Shizuo Akira,Arturo Zychlinsky,Edgardo Moreno,Infection and Immunity,Vol. 73,No. 8,p. 5137-5143,2005年08月,研究論文(学術雑誌)
  • Muramyl dipeptide enhances osteoclast formation induced by lipopolysaccharide, IL-1α, and TNF-α through nucleotide-binding oligomerization domain 2-mediated signaling in osteoblasts,Shuhua Yang,Naoyuki Takahashi,Teruhito Yamashita,Nobuaki Sato,Masahiro Takahashi,Makio Mogi,Takashi Uematsu,Yasuhiro Kobayashi,Yuko Nakamichi,Kiyoshi Takeda,Shizuo Akira,Haruhiko Takada,Nobuyuki Udagawa,Kiyofumi Furusawa,Journal of Immunology,Vol. 175,No. 3,p. 1956-1964,2005年08月01日,研究論文(学術雑誌)
  • Priming effect of lipopolysaccharide on acetyl-coenzyme A: Lyso-platelet-activating factor acetyltransferase is MyD88 and TRIF independent,Hideo Shindou,Satoshi Ishii,Masahiro Yamamoto,Kiyoshi Takeda,Shizuo Akira,Takao Shimizu,Journal of Immunology,American Association of Immunologists,Vol. 175,No. 2,p. 1177-1183,2005年07月15日,研究論文(学術雑誌)
  • Cell type-specific involvement of RIG-I in antiviral response.,Hiroki Kato,Shintaro Sato,Mitsutoshi Yoneyama,Masahiro Yamamoto,Satoshi Uematsu,Kosuke Matsui,Tohru Tsujimura,Kiyoshi Takeda,Takashi Fujita,Osamu Takeuchi,Shizuo Akira,Immunity,Vol. 23,No. 1,p. 19-28,2005年07月,研究論文(学術雑誌)
  • B lymphocyte activation by human papillomavirus-like particles directly induces Ig class switch recombination via TLR4-MyD88,Rongcun Yang,Francisco Martinez Murillo,Michael J. Delannoy,R. Lee Blosser,William H. Yutzy IV,Satoshi Uematsu,Kiyoshi Takeda,Shizuo Akira,Raphael P. Viscidi,Richard B. S. Roden,Journal of Immunology,American Association of Immunologists,Vol. 174,No. 12,p. 7912-7919,2005年06月15日,研究論文(学術雑誌)
  • Papillomavirus capsid mutation to escape dendritic cell-dependent innate immunity in cervical cancer,Rongcun Yang,Cosette M. Wheeler,Xiaojiang Chen,Satoshi Uematsu,Kiyoshi Takeda,Shizuo Akira,Diana V. Pastrana,Raphael P. Viscidi,Richard B. S. Roden,Journal of Virology,Vol. 79,No. 11,p. 6741-6750,2005年06月,研究論文(学術雑誌)
  • Down-regulation of dopamine transporter and abnormal behavior in STAT6-deficient mice.,Kazunori Yukawa,Hiroyuki Iso,Tetsuji Tanaka,Yuji Tsubota,Kyoko Owada-Makabe,Tao Bai,Kiyoshi Takeda,Shizuo Akira,Masanobu Maeda,International journal of molecular medicine,Vol. 15,No. 5,p. 819-25,2005年05月,研究論文(学術雑誌)
  • PI3K integrates the action of insulin and leptin on hypothalamic neurons,Allison Wanting Xu,Christopher B. Kaelin,Kiyoshi Takeda,Shizuo Akira,Michael W. Schwartz,Gregory S. Barsh,Journal of Clinical Investigation,Vol. 115,No. 4,p. 951-958,2005年04月,研究論文(学術雑誌)
  • The nuclear IκB protein IκBNS selectively inhibits lipopolysaccharide-induced IL-6 production in macrophages of the colonic lamina propria,Tomonori Hirotani,Pui Y. Lee,Hirotaka Kuwata,Masahiro Yamamoto,Makoto Matsumoto,Ichiro Kawase,Shizuo Akira,Kiyoshi Takeda,Journal of Immunology,Vol. 174,No. 6,p. 3650-3657,2005年03月15日,研究論文(学術雑誌)
  • Nonredundant roles of Sema4A in the immune system: defective T cell priming and Th1/Th2 regulation in Sema4A-deficient mice.,Atsushi Kumanogoh,Takashi Shikina,Kazuhiro Suzuki,Satoshi Uematsu,Kazunori Yukawa,Shin-Ichiro Kashiwamura,Hiroko Tsutsui,Midori Yamamoto,Hyota Takamatsu,Elizabeth P Ko-Mitamura,Noriko Takegahara,Satoko Marukawa,Isao Ishida,Hiroshi Morishita,Durbaka V R Prasad,Manabu Tamura,Masayuki Mizui,Toshihiko Toyofuku,Shizuo Akira,Kiyoshi Takeda,Masaru Okabe,Hitoshi Kikutani,Immunity,Vol. 22,No. 3,p. 305-16,2005年03月,研究論文(学術雑誌)
  • STAT6 deficiency inhibits tubulointerstitial fibrosis in obstructive nephropathy.,Kazunori Yukawa,Masanori Kishino,Mikako Goda,Xiang-Ming Liang,Akihiko Kimura,Tetsuji Tanaka,Tao Bai,Kyoko Owada-Makabe,Yuji Tsubota,Takashi Ueyama,Masakazu Ichinose,Masanobu Maeda,Kiyoshi Takeda,Shizuo Akira,International journal of molecular medicine,Vol. 15,No. 2,p. 225-30,2005年02月,研究論文(学術雑誌)
  • Roles of Stat3 and ERK in G-CSF signaling,Kenjirou Kamezaki,Kazuya Shimoda,Akihiko Numata,Takashi Haro,Haruko Kakumitsu,Masumi Yoshie,Masahiro Yamamoto,Kiyoshi Takeda,Tadashi Matsuda,Shizuo Akira,Katsuhiro Ogawa,Mine Harada,Stem Cells,Vol. 23,No. 2,p. 252-263,2005年02月,研究論文(学術雑誌)
  • The kinase domain of death-associated protein kinase is inhibitory for tubulointerstitial fibrosis in chronic obstructive nephropathy.,Kazunori Yukawa,Masanori Kishino,Katsuaki Hoshino,Nobuyuki Shirasawa,Akihiko Kimura,Yuji Tsubota,Kyoko Owada-Makabe,Tao Bai,Tetsuji Tanaka,Takashi Ueyama,Masakazu Ichinose,Kiyoshi Takeda,Shizuo Akira,Masanobu Maeda,International journal of molecular medicine,Vol. 15,No. 1,p. 73-8,2005年01月,研究論文(学術雑誌)
  • Toll-like receptor,Kiyoshi Takeda,Japanese Journal of Clinical Immunology,Vol. 28,No. 5,p. 309-317,2005年,研究論文(学術雑誌)
  • IL-12p40 and IL-18 in crescentic glomerulonephritis: IL-12p40 is the key Th1-defining cytokine chain, whereas IL-18 promotes local inflammation and leukocyte recruitment,A. Richard Kitching,Amanda L. Turner,Gabrielle R. A. Wilson,Timothy Semple,Dragana Odobasic,Jennifer R. Timoshanko,Kim M. O'Sullivan,Peter G. Tipping,Kiyoshi Takeda,Shizuo Akira,Stephen R. Holdsworth,Journal of the American Society of Nephrology,Vol. 16,No. 7,p. 2023-2033,2005年,研究論文(学術雑誌)
  • MyD88-deficient mice develop severe intestinal inflammation in dextran sodium sulfate colitis,Akihiro Araki,Takanori Kanai,Takahiro Ishikura,Shin Makita,Koji Uraushihara,Ryoichi Iiyama,Teruji Totsuka,Kiyoshi Takeda,Shizuo Akira,Mamoru Watanabe,Journal of Gastroenterology,Vol. 40,No. 1,p. 16-23,2005年01月,研究論文(学術雑誌)
  • Evolution and integration of innate immune recognition systems: The Toll-like receptors,Kiyoshi Takeda,Journal of Endotoxin Research,Vol. 11,No. 1,p. 51-55,2005年,研究論文(学術雑誌)
  • Differential roles of toll-like receptors 2 and 4 in in vitro responses of macrophages to Legionella pneumophila,Morikazu Akamine,Futoshi Higa,Noriko Arakaki,Kazuyoshi Kawakami,Kiyoshi Takeda,Shizuo Akira,Atsushi Saito,Infection and Immunity,Vol. 73,No. 1,p. 352-361,2005年01月,研究論文(学術雑誌)
  • Osteoclast differentiation is impaired in the absence of inhibitor of κB kinase α,Michelle L. Chaisson,Daniel G. Branstetter,Jonathan M. Derry,Allison P. Armstrong,Mark E. Tometsko,Kiyoshi Takeda,Shizuo Akira,William C. Dougall,Journal of Biological Chemistry,Vol. 279,No. 52,p. 54841-54848,2004年12月24日,研究論文(学術雑誌)
  • In vivo transfection of a cis element 'decoy' against signal transducers and activators of transcription 6 (STAT6)-binding site ameliorates IgE-mediated late-phase reaction in an atopic dermatitis mouse model,H. Yokozeki,M. H. Wu,K. Sumi,K. Awad,T. Satoh,I. Katayama,K. Takeda,S. Akira,Y. Kaneda,K. Nishioka,Gene Therapy,Vol. 11,No. 24,p. 1753-1762,2004年12月,研究論文(学術雑誌)
  • In vivo transfection of a cis element 'decoy' against signal transducers and activators of the transcription 6 (STAT6) binding site ameliorates the response of contact hypersensitivity,K. Sumi,H. Yokozeki,M. H. Wu,T. Satoh,Y. Kaneda,K. Takeda,S. Akira,K. Nishioka,Gene Therapy,Vol. 11,No. 24,p. 1763-1771,2004年12月,研究論文(学術雑誌)
  • Papillomavirus-like particles stimulate murine bone marrow-derived dendritic cells to produce alpha interferon and Th1 immune responses via MyD88,Rongcun Yang,Francisco Martinez Murillo,Hengmi Cui,Richard Blosser,Satoshi Uematsu,Kiyoshi Takeda,Shizuo Akira,Raphael P. Viscidi,Richard B. S. Roden,Journal of Virology,Vol. 78,No. 20,p. 11152-11160,2004年10月,研究論文(学術雑誌)
  • Limited role for interleukin-18 in the host protection response to pulmonary infection with Pseudomonas aeruginosa in mice,Chikara Nakasone,Kazuyoshi Kawakami,Tomoaki Hoshino,Yusuke Kawase,Koichi Yokota,Kohichiro Yoshino,Kiyoshi Takeda,Shizuo Akira,Atsushi Saito,Infection and Immunity,Vol. 72,No. 10,p. 6176-6180,2004年10月,研究論文(学術雑誌)
  • MyD88 but not TRIF is essential for osteoclastogenesis induced by lipopolysaccharide, diacyl lipopeptide, and IL-1alpha.,Nobuaki Sato,Naoyuki Takahashi,Koji Suda,Midori Nakamura,Mariko Yamaki,Tadashi Ninomiya,Yasuhiro Kobayashi,Haruhiko Takada,Kenichiro Shibata,Masahiro Yamamoto,Kiyoshi Takeda,Shizuo Akira,Toshihide Noguchi,Nobuyuki Udagawa,The Journal of experimental medicine,Vol. 200,No. 5,p. 601-11,2004年09月06日,研究論文(学術雑誌)
  • Human papillomavirus type-16 virus-like particles activate complementary defense responses in key dendritic cell subpopulations,Rongcun Yang,Francisco Martinez Murillo,Ken-Yu Lin,William H. Yutzy IV,Satoshi Uematsu,Kiyoshi Takeda,Shizuo Akira,Raphael P. Viscidi,Richard B. S. Roden,Journal of Immunology,American Association of Immunologists,Vol. 173,No. 4,p. 2624-2631,2004年08月15日,研究論文(学術雑誌)
  • Expression of toll-like receptor 4 on dendritic cells is significant for anticancer effect of dendritic cell-based immunotherapy in combination with an active component of OK-432, a streptococcal preparation,Masato Okamoto,Sachiko Furuichi,Yasuhiko Nishioka,Tetsuya Oshikawa,Tomoyuki Tano,Sharif Uddin Ahmed,Kiyoshi Takeda,Shizuo Akira,Yoshiki Ryoma,Yoichiro Moriya,Motoo Saito,Saburo Sone,Mitsunobu Sato,Cancer Research,Vol. 64,No. 15,p. 5461-5470,2004年08月01日,研究論文(学術雑誌)
  • Insulin secretory defects and impaired islet architecture in pancreatic beta-cell-specific STAT3 knockout mice.,Shin-Ichi Gorogawa,Yoshio Fujitani,Hideaki Kaneto,Yoji Hazama,Hirotaka Watada,Yasuhide Miyamoto,Kiyoshi Takeda,Shizuo Akira,Mark A Magnuson,Yoshimitsu Yamasaki,Yoshitaka Kajimoto,Masatsugu Hori,Biochemical and biophysical research communications,Vol. 319,No. 4,p. 1159-70,2004年07月09日,研究論文(学術雑誌)
  • Regulation of Toll/IL-1-receptor-mediated gene expression by the inducible nuclear protein IkappaBzeta.,Masahiro Yamamoto,Soh Yamazaki,Satoshi Uematsu,Shintaro Sato,Hiroaki Hemmi,Katsuaki Hoshino,Tsuneyasu Kaisho,Hirotaka Kuwata,Osamu Takeuchi,Koichiro Takeshige,Tatsuya Saitoh,Shoji Yamaoka,Naoki Yamamoto,Shunsuke Yamamoto,Tatsushi Muta,Kiyoshi Takeda,Shizuo Akira,Nature,Vol. 430,No. 6996,p. 218-22,2004年07月08日,研究論文(学術雑誌)
  • Deletion of the kinase domain in death-associated protein kinase attenuates tubular cell apoptosis in renal ischemia-reperfusion injury,Masanori Kishino,Kazunori Yukawa,Katsuaki Hoshino,Akihiko Kimura,Nobuyuki Shirasawa,Haruhisa Otani,Tetsuji Tanaka,Kyoko Owada-Makabe,Yuji Tsubota,Masanobu Maeda,Masakazu Ichinose,Kiyoshi Takeda,Shizuo Akira,Masatoshi Mune,Journal of the American Society of Nephrology,Vol. 15,No. 7,p. 1826-1834,2004年07月,研究論文(学術雑誌)
  • The roles of two IkappaB kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infection.,Hiroaki Hemmi,Osamu Takeuchi,Shintaro Sato,Masahiro Yamamoto,Tsuneyasu Kaisho,Hideki Sanjo,Taro Kawai,Katsuaki Hoshino,Kiyoshi Takeda,Shizuo Akira,The Journal of experimental medicine,Vol. 199,No. 12,p. 1641-50,2004年06月21日,研究論文(学術雑誌)
  • Functions of toll-like receptors: Lessons from KO mice,Shizuo Akira,Kiyoshi Takeda,Comptes Rendus - Biologies,Vol. 327,No. 6,p. 581-589,2004年06月,研究論文(学術雑誌)
  • IL-18 gene therapy develops Th1-type immune responses in Leishmania major-infected BALB/c mice: Is the effect mediated by the CpG signaling TLR9?,Y. Li,K. Ishii,H. Hisaeda,S. Hamano,M. Zhang,K. Nakanishi,T. Yoshimoto,H. Hemmi,K. Takeda,S. Akira,Y. Iwakura,K. Himeno,Gene Therapy,Vol. 11,No. 11,p. 941-948,2004年06月,研究論文(学術雑誌)
  • Deletion of the kinase domain in death-associated protein kinase attenuates renal tubular cell apoptosis in chronic obstructive uropathy.,Kazunori Yukawa,Katsuaki Hoshino,Masanori Kishino,Masatoshi Mune,Nobuyuki Shirasawa,Akihiko Kimura,Yuji Tsubota,Kyoko Owada-Makabe,Tetsuji Tanaka,Masakazu Ichinose,Masanobu Maeda,Kiyoshi Takeda,Shizuo Akira,International journal of molecular medicine,Vol. 13,No. 4,p. 515-20,2004年04月,研究論文(学術雑誌)
  • Interferon-γ production and host protective response against Mycobacterium tuberculosis in mice lacking both IL-12p40 and IL-18,Kazuyoshi Kawakami,Yuki Kinjo,Kaori Uezu,Kazuya Miyagi,Takeshi Kinjo,Satomi Yara,Yoshinobu Koguchi,Akiko Miyazato,Kazutoshi Shibuya,Yoichiro Iwakura,Kiyoshi Takeda,Shizuo Akira,Atsushi Saito,Microbes and Infection,Vol. 6,No. 4,p. 339-349,2004年04月,研究論文(学術雑誌)
  • Toll-Like Receptors Are Temporally Involved in Host Defense,David S. Weiss,Bärbel Raupach,Kiyoshi Takeda,Shizuo Akira,Arturo Zychlinsky,Journal of Immunology,American Association of Immunologists,Vol. 172,No. 7,p. 4463-4469,2004年04月01日,研究論文(学術雑誌)
  • Production of IL-12 by Macrophages Infected with Toxoplasma gondii Depends on the Parasite Genotype,Paul M. Robben,Dana G. Mordue,Steven M. Truscott,Kiyoshi Takeda,Shizuo Akira,L. David Sibley,Journal of Immunology,American Association of Immunologists,Vol. 172,No. 6,p. 3686-3694,2004年03月15日,研究論文(学術雑誌)
  • Role of STAT-3 in regulation of hepatic gluconeogenic genes and carbohydrate metabolism in vivo,Hiroshi Inoue,Wataru Ogawa,Michitaka Ozaki,Sanae Haga,Michihiro Matsumoto,Kensuke Furukawa,Naoko Hashimoto,Yoshiaki Kido,Toshiyuki Mori,Hiroshi Sakaue,Kiyoshi Teshigawara,Shiyu Jin,Haruhisa Iguchi,Ryuji Hiramatsu,Derek LeRoith,Kiyoshi Takeda,Shizuo Akira,Masato Kasuga,Nature Medicine,Vol. 10,No. 2,p. 168-174,2004年02月,研究論文(学術雑誌)
  • Adjuvant-Mediated Tumor Regression and Tumor-Specific Cytotoxic Response Are Impaired in MyD88-Deficient Mice,Takashi Akazawa,Hisayo Masuda,Yoshiko Saeki,Misako Matsumoto,Kiyoshi Takeda,Kunio Tsujimura,Kiyotaka Kuzushima,Toshitada Takahashi,Ichiro Azuma,Shizuo Akira,Kumao Toyoshima,Tsukasa Seya,Cancer Research,Vol. 64,No. 2,p. 757-764,2004年01月15日,研究論文(学術雑誌)
  • Stat-3 is required for pulmonary homeostasis during hyperoxia,Isamu Hokuto,Machiko Ikegami,Mitsuhiro Yoshida,Kiyoshi Takeda,Shizuo Akira,Anne-Karina T. Perl,William M. Hull,Susan E. Wert,Jeffrey A. Whitsett,Journal of Clinical Investigation,The American Society for Clinical Investigation,Vol. 113,No. 1,p. 28-37,2004年,研究論文(学術雑誌)
  • Toll-Like Receptor 9 Signaling Mediates the Anti-inflammatory Effects of Probiotics in Murine Experimental Colitis,Daniel Rachmilewitz,Kyoko Katakura,Fanny Karmeli,Tomoko Hayashi,Constantin Reinus,Bernard Rudensky,Shizuo Akira,Kiyoshi Takeda,Jongdae Lee,Kenji Takabayashi,Eyal Raz,Gastroenterology,W.B. Saunders,Vol. 126,No. 2,p. 520-528,2004年,研究論文(学術雑誌)
  • Expression of Toll-like receptors 2 and 4 is downregulated after operation,Hirofumi Ikushima,Toshirou Nishida,Kiyoshi Takeda,Toshinori Ito,Takushi Yasuda,Masahiko Yano,Shizuo Akira,Hikaru Matsuda,Surgery,Mosby Inc.,Vol. 135,No. 4,p. 376-385,2004年,研究論文(学術雑誌)
  • IL-1R-Associated Kinase 4 Is Required for Lipopolysaccharide-Induced Activation of APC,Nobutaka Suzuki,Shinobu Suzuki,Urs Eriksson,Hiromitsu Hara,Christine Mirtosis,Nien-Jung Chen,Teiji Wada,Denis Bouchard,Irene Hwang,Kiyoshi Takeda,Takashi Fujita,Sandy Der,Josef M. Penninger,Shizuo Akira,Takashi Saito,Wen-Chen Yeh,Journal of Immunology,American Association of Immunologists,Vol. 171,No. 11,p. 6065-6071,2003年12月01日,研究論文(学術雑誌)
  • Toll-Like Receptor 2 Pathway Drives Streptococcal Cell Wall-Induced Joint Inflammation: Critical Role of Myeloid Differentiation Factor 88,Leo A. B. Joosten,Marije I. Koenders,Ruben L. Smeets,Marleen Heuvelmans-Jacobs,Monique M. A. Helsen,Kiyoshi Takeda,Shizuo Akira,Erik Lubberts,Fons A. J. Van De Loo,Wim B. Van Den Berg,Journal of Immunology,American Association of Immunologists,Vol. 171,No. 11,p. 6145-6153,2003年12月01日,研究論文(学術雑誌)
  • Aberrant Inflammation and Lethality to Septic Peritonitis in Mice Lacking STAT3 in Macrophages and Neutrophils,Akihiro Matsukawa,Kiyoshi Takeda,Shinji Kudo,Takako Maeda,Motoko Kagayama,Shizuo Akira,Journal of Immunology,American Association of Immunologists,Vol. 171,No. 11,p. 6198-6205,2003年12月01日,研究論文(学術雑誌)
  • IL-10-inducible Bcl-3 negatively regulates LPS-induced TNF-α production in macrophages,Hirotaka Kuwata,Yasuyuki Watanabe,Hiroyuki Miyoshi,Masahiro Yamamoto,Tsuneyasu Kaisho,Kiyoshi Takeda,Shizuo Akira,Blood,Vol. 102,No. 12,p. 4123-4129,2003年12月01日,研究論文(学術雑誌)
  • The Toll-like receptor 7 (TLR7)-specific stimulus loxoribine uncovers a strong relationship within the TLR7, 8 and 9 subfamily.,Florian Heil,Parviz Ahmad-Nejad,Hiroaki Hemmi,Hubertus Hochrein,Franziska Ampenberger,Tanja Gellert,Harald Dietrich,Grayson Lipford,Kiyoshi Takeda,Shizuo Akira,Hermann Wagner,Stefan Bauer,European journal of immunology,Vol. 33,No. 11,p. 2987-97,2003年11月,研究論文(学術雑誌)
  • TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway,M Yamamoto,S Sato,H Hemmi,S Uematsu,K Hoshino,T Kaisho,O Takeuchi,K Takeda,S Akira,NATURE IMMUNOLOGY,NATURE PUBLISHING GROUP,Vol. 4,No. 11,p. 1144-1150,2003年11月,研究論文(学術雑誌)
  • Toll/IL-1 receptor domain-containing adaptor inducing IFN-β (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-κB and IFN-regulatory factor-3, in the toll-like receptor signaling,Shintaro Sato,Masanaka Sugiyama,Masahiro Yamamoto,Yasuyuki Watanabe,Taro Kawai,Kiyoshi Takeda,Shizuo Akira,Journal of Immunology,Vol. 171,No. 8,p. 4304-4310,2003年10月15日,研究論文(学術雑誌)
  • MyD88 primes macrophages for full-scale activation by interferon-γ yet mediates few responses to Mycobacterium tuberculosis,Shuangping Shi,Carl Nathan,Dirk Schnappinger,Jörg Drenkow,Michele Fuortes,Ellen Block,Aihao Ding,Thomas R. Gingeras,Gary Schoolnik,Shizuo Akira,Kiyoshi Takeda,Sabine Ehrt,Journal of Experimental Medicine,Vol. 198,No. 7,p. 987-997,2003年10月06日,研究論文(学術雑誌)
  • Stat3 protects against Fas-induced liver injury by redox-dependent and -independent mechanisms,Sanae Haga,Keita Terui,Hui Qi Zhang,Shin Enosawa,Wataru Ogawa,Hiroshi Inoue,Torayuki Okuyama,Kiyoshi Takeda,Shizuo Akira,Tetsuya Ogino,Kaikobad Irani,Michitaka Ozaki,Journal of Clinical Investigation,Vol. 112,No. 7,p. 989-998,2003年10月,研究論文(学術雑誌)
  • Immunogenicity of peptide-25 of Ag85B in Th 1 development: Role of IFN-γ,Ai Kariyone,Toshiki Tamura,Hideyuki Kano,Yoichiro Iwakura,Kiyoshi Takeda,S. Akira,Kiyoshi Takatsu,International Immunology,Vol. 15,No. 10,p. 1183-1194,2003年10月01日,研究論文(学術雑誌)
  • Interleukin-18 facilitates the early antimicrobial host response to Escherichia coli peritonitis,Sebastiaan Weijer,Miguel E. Sewnath,Alex F. De Vos,Sandrine Florctuin,Koen Van der Sluis,Dirk J. Gouma,Kiyoshi Takeda,Shizuo Akira,Tom Van der Poll,Infection and Immunity,Vol. 71,No. 10,p. 5488-5497,2003年10月01日,研究論文(学術雑誌)
  • Integral role of Noxa in p53-mediated apoptotic response,Tsukasa Shibue,Kiyoshi Takeda,Eri Oda,Hiroshi Tanaka,Hideki Murasawa,Akinori Takaoka,Yasuyuki Morishita,Shizuo Akira,Tadatsugu Taniguchi,Nobuyuki Tanaka,Genes and Development,Vol. 17,No. 18,p. 2233-2238,2003年09月15日,研究論文(学術雑誌)
  • A critical role for Stat3 signaling in immune tolerance,Fengdong Cheng,Hong-Wei Wang,Alex Cuenca,Mei Huang,Tomar Ghansah,Jason Brayer,William G. Kerr,Kiyoshi Takeda,Shizuo Akira,Stephen P. Schoenberger,Hua Yu,Richard Jove,Eduardo M. Sotomayor,Immunity,Cell Press,Vol. 19,No. 3,p. 425-436,2003年09月01日,研究論文(学術雑誌)
  • Analysis of cytokine regulators inducing interferon production by mouse uterine natural killer cells,J. H. Zhang,H. He,A. M. Borzychowski,K. Takeda,S. Akira,B. A. Croy,Biology of Reproduction,Vol. 69,No. 2,p. 404-411,2003年08月01日,研究論文(学術雑誌)
  • Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway,M Yamamoto,S Sato,H Hemmi,K Hoshino,T Kaisho,H Sanjo,O Takeuchi,M Sugiyama,M Okabe,K Takeda,S Akira,SCIENCE,AMER ASSOC ADVANCEMENT SCIENCE,Vol. 301,No. 5633,p. 640-643,2003年08月,研究論文(学術雑誌)
  • Reduced atherosclerosis in interleukin-18 deficient apolipoprotein E-knockout mice,Rima Elhage,Jacek Jawien,Mats Rudling,Hans-Gustaf Ljunggren,Kiyoshi Takeda,Shizuo Akira,Francis Bayard,Göran K. Hansson,Cardiovascular Research,Vol. 59,No. 1,p. 234-240,2003年07月01日,研究論文(学術雑誌)
  • Th2 cytokines, IgE and mast cells play a crucial role in the induction of para-phenylenediamine-induced contact hypersensitivity in mice,Hiroo Yokozeki,M. H. Wu,K. Sumi,K. Igawa,Y. Miyazaki,I. Katayama,K. Takeda,S. Akira,K. Nishioka,Clinical and Experimental Immunology,Vol. 132,No. 3,p. 385-392,2003年06月01日,研究論文(学術雑誌)
  • Role of adapters in Toll-like receptor signalling,S. Akira,M. Yamamoto,K. Takeda,Biochemical Society Transactions,Vol. 31,No. 3,p. 637-642,2003年06月,研究論文(国際会議プロシーディングス)
  • IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages,Hideo Yasukawa,Masanobu Ohishi,Hiroyuki Mori,Masaaki Murakami,Takatoshi Chinen,Daisuke Aki,Toshikatsu Hanada,Kiyoshi Takeda,Shizuo Akira,Masahiko Hoshijima,Toshio Hirano,Kenneth R. Chien,Akihiko Yoshimura,Nature Immunology,Vol. 4,No. 6,p. 551-556,2003年06月01日,研究論文(学術雑誌)
  • No role for interleukin-18 in acute murine stroke-induced brain injury,Rachel D. Wheeler,Herve Boutin,Omar Touzani,Giamal N. Luheshi,Kiyoshi Takeda,Nancy J. Rothwell,Journal of Cerebral Blood Flow and Metabolism,Lippincott Williams and Wilkins,Vol. 23,No. 5,p. 531-535,2003年05月01日,研究論文(学術雑誌)
  • Interleukin-18 impairs the pulmonary host response to Pseudomonas aeruginosa,Marc J. Schultz,Sylvia Knapp,Sandrine Florquin,Jennie Pater,Kiyoshi Takeda,Shizuo Akira,Tom Van der Poll,Infection and Immunity,Vol. 71,No. 4,p. 1630-1634,2003年04月01日,研究論文(学術雑誌)
  • The roles of Toll-like receptor 9, MyD88, and DNA-dependent protein kinase catalytic subunit in the effects of two distinct CpG DNAs on dendritic cell subsets.,Hiroaki Hemmi,Tsuneyasu Kaisho,Kiyoshi Takeda,Shizuo Akira,Journal of immunology (Baltimore, Md. : 1950),Vol. 170,No. 6,p. 3059-64,2003年03月15日,研究論文(学術雑誌)
  • TAB2 is essential for prevention of apoptosis in fetal liver but not for interleukin-1 signaling,Hideki Sanjo,Kiyoshi Takeda,Tohru Tsujimura,Jun Ninomiya-Tsuji,Kunihiro Matsumoto,Shizuo Akira,Molecular and Cellular Biology,Vol. 23,No. 4,p. 1231-1238,2003年02月,研究論文(学術雑誌)
  • Prion pathogenesis in the absence of Toll-like receptor signalling,Marco Prinz,Mathias Heikenwalder,Petra Schwarz,Kiyoshi Takeda,Shizuo Akira,Adriano Aguzzi,EMBO Reports,Vol. 4,No. 2,p. 195-199,2003年02月01日,研究論文(学術雑誌)
  • Mycobacterial Infection in MyD88-Deficient Mice,Isamu Sugawara,Hiroyuki Yamada,Satoru Mizuno,Kiyoshi Takeda,Shizuo Akira,Microbiology and Immunology,Center for Academic Publications Japan,Vol. 47,No. 11,p. 841-847,2003年,研究論文(学術雑誌)
  • Impairment of interleukin-1 (IL-1) signaling reduces basal pain sensitivity in mice: Genetic, pharmacological and developmental aspects,Gilly Wolf,Raz Yirmiya,Inbal Goshen,Kerstin Iverfeldt,Linda Holmlund,Kiyoshi Takeda,Yehuda Shavit,Pain,Elsevier,Vol. 104,No. 3,p. 471-480,2003年,研究論文(学術雑誌)
  • Interleukin-18 gene-deficient mice show enhanced defense and reduced inflammation during pneumococcal meningitis,Petra J.G. Zwijnenburg,Tom Van Der Poll,Sandrine Florquin,Shizuo Akira,Kiyoshi Takeda,John J. Roord,A. Marceline Van Furth,Journal of Neuroimmunology,Elsevier,Vol. 138,No. 1-2,p. 31-37,2003年,研究論文(学術雑誌)
  • Toll-like receptor-dependent production of IL-12p40 causes chronic enterocolitis in myeloid cell-specific Stat3-deficient mice,Masaya Kobayashi,Mi-Na Kweon,Hirotaka Kuwata,Robert D. Schreiber,Hiroshi Kiyono,Kiyoshi Takeda,Shizuo Akira,Journal of Clinical Investigation,The American Society for Clinical Investigation,Vol. 111,No. 9,p. 1297-1308,2003年,研究論文(学術雑誌)
  • Development of colitis in signal transducers and activators of transcription 6-deficient T-cell receptor α-deficient mice: A potential role of signal transducers and activators of transcription 6-independent interleukin-4 signaling for the generation of Th2-biased pathological CD4+ ββT cells,Yoshiko Okuda,Ichiro Takahashi,Jin-Kyung Kim,Noriyuki Ohta,Kouichi Iwatani,Hideki Iijima,Yasuyuki Kai,Hiroshi Tamagawa,Takachika Hiroi,Mi-Na Kweon,Sunao Kawano,Kiyoshi Takeda,Sizuo Akira,Yutaka Sasaki,Masatsugu Hori,Hiroshi Kiyono,American Journal of Pathology,American Society for Investigative Pathology Inc.,Vol. 162,No. 1,p. 263-271,2003年01月01日,研究論文(学術雑誌)
  • Cutting edge: A novel toll/IL-1 receptor Domain containing adapter that preferentially activates the IFN-beta promoter in the toll-like receptor signaling,M Yamamoto,S Sato,K Mori,K Hoshino,O Takeuchi,K Takeda,S Akira,JOURNAL OF IMMUNOLOGY,AMER ASSOC IMMUNOLOGISTS,Vol. 169,No. 12,p. 6668-6672,2002年12月,研究論文(学術雑誌)
  • Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4.,Masahiro Yamamoto,Shintaro Sato,Hiroaki Hemmi,Hideki Sanjo,Satoshi Uematsu,Tsuneyasu Kaisho,Katsuaki Hoshino,Osamu Takeuchi,Masaya Kobayashi,Takashi Fujita,Kiyoshi Takeda,Shizuo Akira,Nature,Vol. 420,No. 6913,p. 324-9,2002年11月21日,研究論文(学術雑誌)
  • SOCS-1 participates in negative regulation of LPS responses,Reiko Nakagawa,Tetsuji Naka,Hiroko Tsutsui,Minoru Fujimoto,Akihiro Kimura,Tatsuo Abe,Ekihiro Seki,Shintaro Sato,Osamu Takeuchi,Kiyoshi Takeda,Shizuo Akira,Koichi Yamanishi,Ichirou Kawase,Kenji Nakanishi,Tadamitsu Kishimoto,Immunity,Vol. 17,No. 5,p. 677-687,2002年11月01日,研究論文(学術雑誌)
  • IL-18 contributes to the spontaneous development of atopic dermatitis-like inflammatory skin lesion independently of IgE/stat6 under specific pathogen-free conditions,Hiroshi Konishi,Hiroko Tsutsui,Takaaki Murakami,Shizue Yumikura-Futatsugi,Kei-ichi Yamanaka,Minoru Tanaka,Yohichiro Iwakura,Noboru Suzuki,Kiyoshi Takeda,Shizuo Akira,Kenji Nakanishi,Hitoshi Mizutani,Proceedings of the National Academy of Sciences of the United States of America,Vol. 99,No. 17,p. 11340-11345,2002年08月20日,研究論文(学術雑誌)
  • A variety of microbial components induce tolerance to lipopolysaccharide by differentially affecting MyD88-dependent and -independent pathways.,Shintaro Sato,Osamu Takeuchi,Takashi Fujita,Hideyuki Tomizawa,Kiyoshi Takeda,Shizuo Akira,International immunology,Vol. 14,No. 7,p. 783-91,2002年07月,研究論文(学術雑誌)
  • Proteolytic processing of Stat6 signaling in mast cells as a negative regulatory mechanism,Kotaro Suzuki,Hiroshi Nakajima,Shin-Ichiro Kagami,Akira Suto,Kei Ikeda,Koichi Hirose,Takaki Hiwasa,Kiyoshi Takeda,Yasushi Saito,Shizuo Akira,Itsuo Iwamoto,Journal of Experimental Medicine,Vol. 196,No. 1,p. 27-38,2002年07月01日,研究論文(学術雑誌)
  • Contribution of IL-18 to Th1 response and host defense against infection by Mycobacterium tuberculosis: A comparative study with IL-12p40,Yuki Kinjo,Kazuyoshi Kawakami,Kaori Uezu,Satomi Yara,Kazuya Miyagi,Yoshinobu Koguchi,Tomoaki Hoshino,Masaki Okamoto,Yusuke Kawase,Koichi Yokota,Kohichiro Yoshino,Kiyoshi Takeda,Shizuo Akira,Atsushi Saito,Journal of Immunology,American Association of Immunologists,Vol. 169,No. 1,p. 323-329,2002年07月01日,研究論文(学術雑誌)
  • Cutting edge: Role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins,Osamu Takeuchi,Shintaro Sato,Takao Horiuchi,Katsuaki Hoshino,Kiyoshi Takeda,Zhongyun Dong,Robert L. Modlin,Shizuo Akira,Journal of Immunology,Vol. 169,No. 1,p. 10-14,2002年07月01日,研究論文(学術雑誌)
  • Lipopolysaccharide-dependent prostaglandin E2 production is regulated by the glutathione-dependent prostaglandin E2 synthase gene induced by the toll-like receptor 4/MyD88/NF-IL6 pathway,Satoshi Uematsu,Makoto Matsumoto,Kiyoshi Takeda,Shizuo Akira,Journal of Immunology,American Association of Immunologists,Vol. 168,No. 11,p. 5811-5816,2002年06月01日,研究論文(学術雑誌)
  • Essential immunoregulatory role for BCAP in B cell development and function,Tetsuo Yamazaki,Kiyoshi Takeda,Kumiko Gotoh,Hiroshi Takeshima,Shizuo Akira,Tomohiro Kurosaki,Journal of Experimental Medicine,Vol. 195,No. 5,p. 535-545,2002年03月04日,研究論文(学術雑誌)
  • Priming of macrophages with lipopolysaccharide potentiates P2X7-mediated cell death via a caspase-1-dependent mechanism, independently of cytokine production,Rosalind A. Le Feuvre,David Brough,Yoichiro Iwakura,Kiyoshi Takeda,Nancy J. Rothwell,Journal of Biological Chemistry,Vol. 277,No. 5,p. 3210-3218,2002年02月01日,研究論文(学術雑誌)
  • Conditional gene ablation of Stat3 reveals differential signaling requirements for survival of motoneurons during development and after nerve injury in the adult,Ulrich Schweizer,Jennifer Gunnersen,Christoph Karch,Stefan Wiese,Bettina Holtmann,Kiyoshi Takeda,Shizuo Akira,Michael Sendtner,Journal of Cell Biology,Vol. 156,No. 2,p. 287-297,2002年01月21日,研究論文(学術雑誌)
  • Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes,Seiichi Oyadomari,Akio Koizumi,Kiyoshi Takeda,Tomomi Gotoh,Shizuo Akira,Eiichi Araki,Masataka Mori,Journal of Clinical Investigation,The American Society for Clinical Investigation,Vol. 109,No. 4,p. 525-532,2002年,研究論文(学術雑誌)
  • Small-antiviral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway,Hiroaki Hemmi,Tsuneyasu Kaisho,Osamu Takeuchi,Shintaro Sato,Hideki Sanjo,Katsuaki Hoshino,Takao Horiuchi,Hideyuki Tomizawa,Kiyoshi Takeda,Shizuo Akira,Nature Immunology,Vol. 3,No. 2,p. 196-200,2002年,研究論文(学術雑誌)
  • Nitric oxide-induced apoptosis in pancreatic β cells is mediated by the endoplasmic reticulum stress pathway,Seiichi Oyadomari,Kiyoshi Takeda,Masaki Takiguchi,Tomomi Gotoh,Makoto Matsumoto,Ikuo Wada,Shizuo Akira,Eiichi Araki,Masataka Mori,Proceedings of the National Academy of Sciences of the United States of America,Vol. 98,No. 19,p. 10845-10850,2001年09月11日,研究論文(学術雑誌)
  • Impaired microglial activation in the brain of IL-18-gene-disrupted mice after neurovirulent influenza A virus infection,Isamu Mori,Md.Jaber Hossain,Kiyoshi Takeda,Haruki Okamura,Yoshinori Imai,Shinichi Kohsaka,Yoshinobu Kimura,Virology,Academic Press Inc.,Vol. 287,No. 1,p. 163-170,2001年08月15日,研究論文(学術雑誌)
  • Discrimination of bacterial lipoproteins by Toll-like receptor 6,TAKEUCHI Osamu,KAWAI Taro,MUHLRADT Peter F.,MORR Michael,RADOLF Justin D.,ZYCHLINSKY Arturo,TAKEDA Kiyoshi,AKIRA Shizuo,International immunology,Vol. 13,No. 7,p. 933-940,2001年07月01日
  • Enhanced resistance in STAT6-deficient mice to infection with ectromelia virus,Surendran Mahalingam,Gunasegaran Karupiah,Kiyoshi Takeda,Shizuo Akira,Klaus I. Matthaei,Paul S. Foster,Proceedings of the National Academy of Sciences of the United States of America,Vol. 98,No. 12,p. 6812-6817,2001年06月05日,研究論文(学術雑誌)
  • Essential role of nuclear factor (NF)-κB-inducing kinase and inhibitor of κB (IκB) kinase α in NF-κB activation through lymphotoxin β receptor, but not through tumor necrosis factor receptor I,Akemi Matsushima,Tsuneyasu Kaisho,Paul D. Rennert,Hiroyasu Nakano,Kyoko Kurosawa,Daisuke Uchida,Kiyoshi Takeda,Shizuo Akira,Mitsuru Matsumoto,Journal of Experimental Medicine,Vol. 193,No. 5,p. 631-636,2001年03月05日,研究論文(学術雑誌)
  • CIS3/SOCS3/SSI3 plays a negative regulatory role in STAT3 activation and intestinal inflammation,Asuka Suzuki,Toshikatsu Hanada,Keiichi Mitsuyama,Takafumi Yoshida,Shintaro Kamizono,Tomoaki Hoshino,Masato Kubo,Atsuko Yamashita,Masaru Okabe,Kiyoshi Takeda,Shizuo Akira,Satoshi Matsumoto,Atsushi Toyonaga,Michio Sata,Akihiko Yoshimura,Journal of Experimental Medicine,Vol. 193,No. 4,p. 471-481,2001年02月19日,研究論文(学術雑誌)
  • IκB kinase α is essential for mature B cell development and function,Tsuneyasu Kaisho,Kiyoshi Takeda,Tohru Tsujimura,Taro Kawai,Fumiko Nomura,Nobuyuki Terada,Shizuo Akira,Journal of Experimental Medicine,Vol. 193,No. 4,p. 417-426,2001年02月19日,研究論文(学術雑誌)
  • Alternations in hepatic expression of fatty-acid metabolizing enzymes in ArKO mice and their reversal by the treatment with 17β-estradiol or a peroxisome proliferator,Katsumi Toda,Kiyoshi Takeda,Shizuo Akira,Toshiji Saibara,Teruhiko Okada,Saburo Onishi,Yutaka Shizuta,Journal of Steroid Biochemistry and Molecular Biology,Vol. 79,No. 1-5,p. 11-17,2001年,研究論文(国際会議プロシーディングス)
  • Oestrogen at the neonatal stage is critical for the reproductive ability of male mice as revealed by supplementation with 17β-oestradiol to aromatase gene (Cyp19) knockout mice,K. Toda,Okada T,K. Takeda,S. Akira,T. Saibara,M. Shiraishi,S. Onishi,Y. Shizuta,Journal of Endocrinology,Vol. 168,No. 3,p. 455-463,2001年,研究論文(学術雑誌)
  • Targeted disruption of the aromatase P450 gene (Cyp19) in mice and their ovarian and uterine responses to 17β-oestradiol,K. Toda,K. Takeda,T. Okada,S. Akira,T. Saibara,T. Kaname,K. Yamamura,S. Onishi,Y. Shizuta,Journal of Endocrinology,Vol. 170,No. 1,p. 99-111,2001年,研究論文(学術雑誌)
  • The role of MyD88 and TLR4 in the LPS-mimetic activity of Taxol,Cynthia A. Byrd-Leifer,Ellen F. Block,Kiyoshi Takeda,Shizuo Akira,Aihao Ding,European Journal of Immunology,Vol. 31,No. 8,p. 2448-2457,2001年,研究論文(学術雑誌)
  • Macrophage-derived IL-18-mediated intestinal inflammation in the murine model of Crohn’s disease,Takanori Kanai,Mamoru Watanabe,Akira Okazawa,Toshiro Sato,Motomi Yamazaki,Susumu Okamoto,Hiromasa Ishii,Teruji Totsuka,Ryoichi Iiyama,Ryuichi Okamoto,Masao Ikeda,Masashi Kurimoto,Kiyoshi Takeda,Shizuo Akira,Toshifumi Hibi,Gastroenterology,Vol. 121,No. 4,p. 875-888,2001年,研究論文(学術雑誌)
  • Toll-like receptors control activation of adaptive immune responses,Markus Schnare,Gregory M. Barton,Agnieszka Czopik Holt,Kiyoshi Takeda,Shizuo Akira,Ruslan Medzhitov,Nature Immunology,Vol. 2,No. 10,p. 947-950,2001年,研究論文(学術雑誌)
  • Synergy and cross-tolerance between Toll-like receptor (TLR) 2- and TLR4-mediated signaling pathways,S. Sato,F. Nomura,T. Kawai,O. Takeuchi,P. F. Muhlradt,K. Takeda,S. Akira,Journal of Immunology,Vol. 165,No. 12,p. 7096-7101,2000年12月15日,研究論文(学術雑誌)
  • A Toll-like receptor recognizes bacterial DNA.,H Hemmi,O Takeuchi,T Kawai,T Kaisho,S Sato,H Sanjo,M Matsumoto,K Hoshino,H Wagner,K Takeda,S Akira,Nature,Vol. 408,No. 6813,p. 740-5,2000年12月07日,研究論文(学術雑誌)
  • Recognition of CpG DNA is mediated by signaling pathways dependent on the adaptor protein MyD88,Markus Schnare,Agnieszka Czopik Holt,Kiyoshi Takeda,Shizuo Akira,Ruslan Medzhitov,Current Biology,Current Biology Ltd,Vol. 10,No. 18,p. 1139-1142,2000年09月21日,研究論文(学術雑誌)
  • Cutting edge: Essential role of phospholipase C-γ2 in B cell development and function,A. Hashimoto,K. Takeda,M. Inaba,M. Sekimata,T. Kaisho,S. Ikehara,Y. Homma,S. Akira,T. Kurosaki,Journal of Immunology,Vol. 165,No. 4,p. 1738-1742,2000年08月15日,研究論文(学術雑誌)
  • IL-18 contributes to host resistance against infection with Cryptococcus neoformans in mice with defective IL-12 synthesis through induction of IFN-γ production by NK cells,Kazuyoshi Kawakami,Yoshinobu Koguchi,Mahboob Hossain Qureshi,Akiko Miyazato,Satomi Yara,Yuki Kinjo,Yoichiro Iwakura,Kiyoshi Takeda,Shizuo Akira,Masashi Kurimoto,Atsushi Saito,Journal of Immunology,Vol. 165,No. 2,p. 941-947,2000年07月15日,研究論文(学術雑誌)
  • Reduced host resistance and Th1 response to Cryptococcus neoformans in interleukin-18 deficient mice,Kazuyoshi Kawakami,Yoshinobu Koguchi,Mahboob Hossain Qureshi,Yuki Kinjo,Satomi Yara,Akiko Miyazato,Masashi Kurimoto,Kiyoshi Takeda,Shizuo Akira,Atsushi Saito,FEMS Microbiology Letters,Vol. 186,No. 1,p. 121-126,2000年05月01日,研究論文(学術雑誌)
  • Potentiality of interleukin-18 as a useful reagent for treatment and prevention of Leishmania major infection,Kazunobu Ohkusu,Tomohiro Yoshimoto,Kiyoshi Takeda,Takeharu Ogura,Shin-Ichiro Kashiwamura,Yoichiro Iwakura,Shizuo Akira,Haruki Okamura,Kenji Nakanishi,Infection and Immunity,Vol. 68,No. 5,p. 2449-2456,2000年05月,研究論文(学術雑誌)
  • Cutting edge: Endotoxin tolerance in mouse peritoneal macrophages correlates with down-regulation of surface Toll-like receptor 4 expression,Fumiko Nomura,Sachiko Akashi,Yoshimitsu Sakao,Shintaro Sato,Taro Kawai,Makoto Matsumoto,Kenji Nakanishi,Masao Kimoto,Kensuke Miyake,Kiyoshi Takeda,Shizuo Akira,Journal of Immunology,American Association of Immunologists,Vol. 164,No. 7,p. 3476-3479,2000年04月01日,研究論文(学術雑誌)
  • Cutting edge: Cell surface expression and lipopolysaccharide signaling via the Toll-like receptor 4-MD-2 complex on mouse peritoneal macrophages,Sachiko Akashi,Rintaro Shimazu,Hirotaka Ogata,Yoshinori Nagai,Kiyoshi Takeda,Masao Kimoto,Kensuke Miyake,Journal of Immunology,American Association of Immunologists,Vol. 164,No. 7,p. 3471-3475,2000年04月01日,研究論文(学術雑誌)
  • Signal transducer and activator of transcription 6 is essential in the induction of contact hypersensitivity,Hiroo Yokozeki,Mehran Ghoreishi,Shinsuke Takagawa,Kaoru Takayama,Takahiro Satoh,Ichiro Katayama,Kiyoshi Takeda,Shizuo Akira,Kiyoshi Nishioka,Journal of Experimental Medicine,Vol. 191,No. 6,p. 995-1004,2000年03月20日,研究論文(学術雑誌)
  • Involvement of endogenously synthesized interleukin (IL)-18 in the protective effects of IL-12 against pulmonary infection with Cryptococcus neoformans in mice,Kazuyoshi Kawakami,Mahboob Hossain Qureshi,Tiantuo Zhang,Yoshinobu Koguchi,Satomi Yara,Kiyoshi Takeda,Shizuo Akira,Masashi Kurimoto,Atsushi Saito,FEMS Immunology and Medical Microbiology,Vol. 27,No. 3,p. 191-200,2000年03月,研究論文(学術雑誌)
  • Mouse Ror2 receptor tyrosine kinase is required for the heart development and limb formation,Shigeto Takeuchi,Kiyoshi Takeda,Isao Oishi,Masashi Nomi,Makoto Ikeya,Kyoko Itoh,Shingo Tamura,Takahiro Ueda,Toshihisa Hatta,Hiroki Otani,Toshio Terashima,Shinji Takada,Hirohei Yamamura,Shizuo Akira,Yasuhiro Minami,Genes to Cells,Vol. 5,No. 1,p. 71-78,2000年,研究論文(学術雑誌)
  • Genetically resistant mice lacking IL-18 gene develop Th1 response and control cutaneous Leishmania major infection,Gina M. Monteforte,Kiyoshi Takeda,Miriam Rodriguez-Sosa,Shizuo Akira,John R. David,Abhay R. Satoskar,Journal of Immunology,American Association of Immunologists,Vol. 164,No. 11,p. 5890-5893,2000年,研究論文(学術雑誌)
  • Biological characteristics of the leukemia-associated transcriptional factor AML1 disclosed by hematopoietic rescue of AML1-deficient embryonic stem cells by using a knock-in strategy,Tsukasa Okuda,Kiyoshi Takeda,Yasuko Fujita,Motohiro Nishimura,Shigeki Yagyu,Makie Yoshida,Shizuo Akira,James R. Downing,Abe Tatsuo,Molecular and Cellular Biology,American Society for Microbiology,Vol. 20,No. 1,p. 319-328,2000年,研究論文(学術雑誌)
  • Caspase-1 activation of IL-1β and IL-18 are essential for Shigella flexneri-induced inflammation,Philippe J. Sansonetti,Armelle Phalipon,Josette Arondel,Kavitha Thirumalai,Subhashis Banerjee,Shizuo Akira,Kiyoshi Takeda,Arturo Zychlinsky,Immunity,Cell Press,Vol. 12,No. 5,p. 581-590,2000年,研究論文(学術雑誌)
  • Impairment of natural killer cytotoxic activity and interferon γ production in CCAAT/enhancer binding protein γ-deficient mice,Tsuneyasu Kaisho,Hiroko Tsutsui,Takashi Tanaka,Tohru Tsujimura,Kiyoshi Takeda,Taro Kawai,Nobuaki Yoshida,Kenji Nakanishi,Shizuo Akira,Journal of Experimental Medicine,Vol. 190,No. 11,p. 1573-1581,1999年12月06日,研究論文(学術雑誌)
  • The absence of interleukin I receptor-related T1/ST2 does not affect T helper cell type 2 development and its effector function,Katsuaki Hoshino,Shin-Ichiro Kashiwamura,Kozo Kuribayashi,Taku Kodama,Tohru Tsujimura,Kenji Nakanishi,Tomohiro Matsuyama,Kiyoshi Takeda,Shizuo Akira,Journal of Experimental Medicine,Vol. 190,No. 10,p. 1541-1547,1999年11月15日,研究論文(学術雑誌)
  • Suppression of epithelial apoptosis and delayed mammary gland involution in mice with a conditional knockout of Stat3,Rachel S. Chapman,Paula C. Lourenco,Elizabeth Tonner,David J. Flint,Stefan Selbert,Kiyoshi Takeda,Shizuo Akira,Alan R. Clarke,Christine J. Watson,Genes and Development,Vol. 13,No. 19,p. 2604-2616,1999年10月01日,研究論文(学術雑誌)
  • Keratinocyte-specific ablation of Stat3 exhibits impaired skin remodeling, but does not affect skin morphogenesis,Shigetoshi Sano,Satoshi Itami,Kiyoshi Takeda,Masahito Tarutani,Yuji Yamaguchi,Hiroyuki Miura,Kunihiko Yoshikawa,Shizuo Akira,Junji Takeda,EMBO Journal,Vol. 18,No. 17,p. 4657-4668,1999年09月01日,研究論文(学術雑誌)
  • Interleukin-10 receptor signaling through the JAK-STAT pathway. Requirement for two distinct receptor-derived signals for anti-inflammatory action,Joan K. Riley,Kiyoshi Takeda,Shizuo Akira,Robert D. Schreiber,Journal of Biological Chemistry,Vol. 274,No. 23,p. 16513-16521,1999年06月04日,研究論文(学術雑誌)
  • Cutting edge: Generation of IL-18 receptor-deficient mice: Evidence for IL-1 receptor-related protein as an essential IL-18 binding receptor,Katsuaki Hoshino,Hiroko Tsutsui,Taro Kawai,Kiyoshi Takeda,Kenji Nakanishi,Yoshifumi Takeda,Shizuo Akira,Journal of Immunology,Vol. 162,No. 9,p. 5041-5044,1999年05月01日,研究論文(学術雑誌)
  • Role of interleukin-18 (IL-18) in mycobacterial infection in IL-18- gene-disrupted mice,Isamu Sugawara,Hiroyuki Yamada,Hirotaka Kaneko,Satoru Mizuno,Kiyoshi Takeda,Shizuo Akira,Infection and Immunity,Vol. 67,No. 5,p. 2585-2589,1999年05月,研究論文(学術雑誌)
  • IL-18 up-regulates perforin-mediated NK activity without increasing perforin messenger RNA expression by binding to constitutively expressed IL- 18 receptor,Yasuko Hyodo,Kiyoshi Matsui,Nobuki Hayashi,Hiroko Tsutsui,Shin-Ichiro Kashiwamura,Hiroshi Yamauchi,Keisai Hiroishi,Kiyoshi Takeda,Yoh-Ichi Tagawa,Yoichiro Iwakura,Nobuhiko Kayagaki,Masashi Kurimoto,Haruki Okamura,Toshikazu Hada,Hideo Yagita,Shizuo Akira,Kenji Nakanishi,Kazuya Higashino,Journal of Immunology,Vol. 162,No. 3,p. 1662-1668,1999年02月01日,研究論文(学術雑誌)
  • Caspase-1-independent, Fas/Fas ligand-mediated IL-18 secretion from macrophages causes acute liver injury in mice,Hiroko Tsutsui,Nobuhiko Kayagaki,Keisuke Kuida,Hiroki Nakano,Nobuki Hayashi,Kiyoshi Takeda,Kiyoshi Matsui,Shin-Ichiro Kashiwamura,Toshikazu Hada,Shizuo Akira,Hideo Yagita,Haruki Okamura,Kenji Nakanishi,Immunity,Cell Press,Vol. 11,No. 3,p. 359-367,1999年,研究論文(学術雑誌)
  • Unresponsiveness of MyD88-deficient mice to endotoxin,Taro Kawai,Osamu Adachi,Tomohiko Ogawa,Kiyoshi Takeda,Shizuo Akira,Immunity,Cell Press,Vol. 11,No. 1,p. 115-122,1999年,研究論文(学術雑誌)
  • Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of stat3 in macrophages and neutrophils,Kiyoshi Takeda,Björn E. Clausen,Tsuneyasu Kaisho,Tohru Tsujimura,Nobuyuki Terada,Irmgard Förster,Shizuo Akira,Immunity,Cell Press,Vol. 10,No. 1,p. 39-49,1999年,研究論文(学術雑誌)
  • IL-18-deficient mice are resistant to endotoxin-induced liver injury but highly susceptible to endotoxin shock,Yoshimitsu Sakao,Kiyoshi Takeda,Hiroko Tsutsui,Tsuneyasu Kaisho,Fumiko Nomura,Haruki Okamura,Kenji Nakanishi,Shizuo Akira,International Immunology,Oxford University Press,Vol. 11,No. 3,p. 471-480,1999年,研究論文(学術雑誌)
  • STAT6 deficiency in a mouse model of allergen-induced airways inflammation abolishes eosinophilia but induces infiltration of CD8+ T cells,S. Miyata,T. Matsuyama,T. Kodama,Y. Nishioka,K. Kuribayashi,K. Takeda,S. Akira,M. Sugita,Clinical and Experimental Allergy,Vol. 29,No. 1,p. 114-123,1999年,研究論文(学術雑誌)
  • IKK-i, a novel lipopolysaccharide-inducible kinase that is related to IκB kinases,Takahiro Shimada,Taro Kawai,Kiyoshi Takeda,Makoto Matsumoto,Jun-Ichiro Inoue,Yoichi Tatsumi,Akihisa Kanamaru,Shizuo Akira,International Immunology,Vol. 11,No. 8,p. 1357-1362,1999年,研究論文(学術雑誌)
  • Kupffer cells from Schistosoma mansoni-infected mice participate in the prompt type 2 differentiation of hepatic T cells in response to worm antigens,Nobuki Hayashi,Kiyoshi Matsui,Hiroko Tsutsui,Yoshio Osada,Raafat T. Mohamed,Hiroki Nakano,Shin-Ichiro Kashiwamura,Yasuko Hyodo,Kiyoshi Takeda,Shizuo Akira,Toshikazu Hada,Kazuya Higashino,Somei Kojima,Kenji Nakanishi,Journal of Immunology,Vol. 163,No. 12,p. 6702-6711,1999年,研究論文(学術雑誌)
  • Stat3 activation is responsible for IL-6-dependent T cell proliferation through preventing apoptosis: Generation and characterization of T cell- specific stat3-deficient mice,Kiyoshi Takeda,Tsuneyasu Kaisho,Nobuaki Yoshida,Junji Takeda,Tadamitsu Kishimoto,Shizuo Akira,Journal of Immunology,Vol. 161,No. 9,p. 4652-4660,1998年11月01日,研究論文(学術雑誌)
  • IL-12 up-regulates IL-18 receptor expression on T cells, Th1 cells, and B cells: Synergism with IL-18 for IFN-γ production,Tomohiro Yoshimoto,Kiyoshi Takeda,Takashi Tanaka,Kazunobu Ohkusu,Shin-Ichiro Kashiwamura,Haruki Okamura,Shizuo Akira,Kenji Nakanishi,Journal of Immunology,Vol. 161,No. 7,p. 3400-3407,1998年10月01日,研究論文(学術雑誌)
  • Abrogation of bronchial eosinophilic inflammation and airway hyperreactivity in signal transducers and activators of transcription (STAT)6-deficient mice,Toshihiko Akimoto,Fumio Numata,Misato Tamura,Yoshimi Takata,Noriko Higashida,Tohru Takashi,Kiyoshi Takeda,Shizuo Akira,Journal of Experimental Medicine,Vol. 187,No. 9,p. 1537-1542,1998年05月04日,研究論文(学術雑誌)
  • Defective NK cell activity and Th1 response in IL-18-deficient mice,Kiyoshi Takeda,Hiroko Tsutsui,Tomohiro Yoshimoto,Osamu Adachi,Nobuaki Yoshida,Tadamitsu Kishimoto,Haruki Okamura,Kenji Nakanishi,Shizuo Akira,Immunity,Cell Press,Vol. 8,No. 3,p. 383-390,1998年,研究論文(学術雑誌)
  • Targeted disruption of ATF4 discloses its essential role in the formation of eye lens fibres,Takashi Tanaka,Tohru Tsujimura,Kiyoshi Takeda,Ayako Sugihara,Akiko Maekawa,Nobuyuki Terada,Nobuaki Yoshida,Shizuo Akira,Genes to Cells,Vol. 3,No. 12,p. 801-810,1998年,研究論文(学術雑誌)
  • Targeted disruption of the MyD88 gene results in loss of IL-1- and IL- 18-mediated function,Osamu Adachi,Taro Kawai,Kiyoshi Takeda,Makoto Matsumoto,Hiroko Tsutsui,Masafumi Sakagami,Kenji Nakanishi,Shizuo Akira,Immunity,Cell Press,Vol. 9,No. 1,p. 143-150,1998年,研究論文(学術雑誌)
  • Zip kinase, a novel serine/threonine kinase which mediates apoptosis,Taro Kawai,Makoto Matsumoto,Kiyoshi Takeda,Hideki Sanjo,Shizuo Akira,Molecular and Cellular Biology,American Society for Microbiology,Vol. 18,No. 3,p. 1642-1651,1998年,研究論文(学術雑誌)
  • Defective IL-2-mediated IL-2 receptor α chain expression in Stat3-deficient T lymphocytes,Hiroshi Akaishi,Kiyoshi Takeda,Tsuneyasu Kaisho,Ryuzaburo Shineha,Susumu Satomi,Junji Takeda,Shizuo Akira,International Immunology,Vol. 10,No. 11,p. 1747-1751,1998年,研究論文(学術雑誌)
  • Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality,Kiyoshi Takeda,Koichi Noguchi,Wei Shi,Takashi Tanaka,Makoto Matsumoto,Nobuaki Yoshida,Tadamitsu Kishimoto,Shizuo Akira,Proceedings of the National Academy of Sciences of the United States of America,Vol. 94,No. 8,p. 3801-3804,1997年04月15日,研究論文(学術雑誌)
  • Signal transducer and activator of transcription protein (STAT): Its relation to Th1/Th2-mediated diseases,Kiyoshi Takeda,Tadamitsu Kishimoto,Shizuo Akira,Nutrition,Vol. 13,No. 11-12,p. 987-988,1997年,研究論文(学術雑誌)
  • Ectopic expression of CHOP (GADD153) induces apoptosis in M1 myeloblastic leukemia cells,Makoto Matsumoto,Masashi Minami,Kiyoshi Takeda,Yoshimitsu Sakao,Shizuo Akira,FEBS Letters,Elsevier B.V.,Vol. 395,No. 2-3,p. 143-147,1996年10月21日,研究論文(学術雑誌)
  • Impaired IL-13-Mediated Functions of Macrophages in STAT6-Deficient Mice,Kiyoshi Takeda,Masahito Kamanaka,Takashi Tanaka,Tadamitsu Kishimoto,Shizuo Akira,Journal of Immunology,Vol. 157,No. 8,p. 3220-3222,1996年10月15日,研究論文(学術雑誌)
  • STAT3 activation is a critical step in gp130-mediated terminal differentiation and growth arrest of a myeloid cell line.,M. Minami,M. Inoue,S. Wei,K. Takeda,M. Matsumoto,T. Kishimoto,S. Akira,Proceedings of the National Academy of Sciences,Proceedings of the National Academy of Sciences,Vol. 93,No. 9,p. 3963-3966,1996年04月30日,研究論文(学術雑誌)
  • The genomic structure and chromosomal localization of the mouse STAT3 gene,Wei Shi,Masahiro Inoue,Masashi Minami,Kiyoshi Takeda,Makoto Matsumoto,Yoichi Matsuda,Tadamitsu Kishimoto,Shizuo Akira,T. Watanabe,International Immunology,Oxford University Press (OUP),Vol. 8,No. 8,p. 1205-1211,1996年,研究論文(学術雑誌)

MISC

  • Innate Myeloid Cell Subset-Specific Gene Expression Patterns in the Human Colon are Altered in Crohn's Disease Patients.,Yuki Sekido,Yoshiaki Yasumizu,Junichi Nishimura,Hisako Kayama,Hiroshi Matsuno,Takayuki Ogino,Norikatsu Miyoshi,Hidekazu Takahashi,Naotsugu Haraguchi,Taishi Hata,Chu Matsuda,Yuichiro Doki,Masaki Mori,Kiyoshi Takeda,Naganari Ohkura,Shimon Sakaguchi,Tsunekazu Mizushima,Digestion,Vol. 99,No. 3,p. 194-204,2019年
  • The Supercarbonate Apatite-MicroRNA Complex Inhibits Dextran Sodium Sulfate-Induced Colitis.,Tadafumi Fukata,Tsunekazu Mizushima,Junichi Nishimura,Daisuke Okuzaki,Xin Wu,Haruka Hirose,Yuhki Yokoyama,Yui Kubota,Kazuya Nagata,Naoto Tsujimura,Akira Inoue,Norikatsu Miyoshi,Naotsugu Haraguchi,Hidekazu Takahashi,Taishi Hata,Chu Matsuda,Hisako Kayama,Kiyoshi Takeda,Yuichiro Doki,Masaki Mori,Hirofumi Yamamoto,Molecular therapy. Nucleic acids,Vol. 12,p. 658-671,2018年09月07日
  • Roles of intestinal epithelial cells in the maintenance of gut homeostasis,Ryu Okumura,Kiyoshi Takeda,EXPERIMENTAL AND MOLECULAR MEDICINE,NATURE PUBLISHING GROUP,Vol. 49,2017年05月,書評論文,書評,文献紹介等
  • Maintenance of gut homeostasis by the mucosal immune system,Ryu Okumura,Kiyoshi Takeda,PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES,JAPAN ACAD,Vol. 92,No. 9,p. 423-435,2016年11月,書評論文,書評,文献紹介等
  • Regulation of allergic inflammation by the ectoenzyme E-NPP3 (CD203c) on basophils and mast cells,Shih Han Tsai,Kiyoshi Takeda,Seminars in Immunopathology,Springer Verlag,Vol. 38,No. 5,p. 571-579,2016年09月01日,書評論文,書評,文献紹介等
  • がん微小環境における代謝と免疫応答 (第5土曜特集 がん標的分子と治療開発 : 現状と将来) -- (がん免疫研究をめぐる最新の動向),香山 尚子,竹田 潔,医学のあゆみ,医歯薬出版,Vol. 258,No. 5,p. 451-454,2016年07月30日
  • Functions of innate immune cells and commensal bacteria in gut homeostasis,Hisako Kayama,Kiyoshi Takeda,JOURNAL OF BIOCHEMISTRY,OXFORD UNIV PRESS,Vol. 159,No. 2,p. 141-149,2016年02月,書評論文,書評,文献紹介等
  • ヒト腸管免疫 (第1土曜特集 ヒト免疫学の新機軸) -- (あたらしいアプローチ),西村 潤一,竹田 潔,医学のあゆみ,医歯薬出版,Vol. 252,No. 1,p. 133-138,2015年01月03日
  • Microbial and dietary factors modulating intestinal regulatory T cell homeostasis,Makoto Kinoshita,Kiyoshi Takeda,FEBS Letters,Elsevier,Vol. 588,No. 22,p. 4182-4187,2014年11月17日,書評論文,書評,文献紹介等
  • Polysaccharide A of Bacteroides fragilis: Actions on Dendritic Cells and T Cells,Hisako Kayama,Kiyoshi Takeda,MOLECULAR CELL,CELL PRESS,Vol. 54,No. 2,p. 206-207,2014年04月
  • 免疫応答の負の制御:免疫恒常性の維持と疾患治療への応用 自然免疫細胞による腸管免疫制御,香山尚子,西村潤一,竹田潔,細胞工学,Vol. 32,No. 12,p. 1205-1210,2013年11月22日
  • 自然免疫細胞における結核菌認識機構 (特集 結核 : 古くて新しい感染症) -- (結核免疫),財賀 大行,竹田 潔,最新医学,最新医学社,Vol. 68,No. 11,p. 2512-2517,2013年11月
  • 自然免疫細胞による腸管粘膜免疫系の制御 (AYUMI 生活習慣病におけるマクロファージ),香山 尚子,竹田 潔,医学のあゆみ,医歯薬出版,Vol. 246,No. 11,p. 954-959,2013年09月14日
  • Recent advances in understanding the role of innate immunity in the pathogenesis of inflammatory bowel disease,Hisako Kayama,Kiyoshi Takeda,Journal of Japanese Society of Gastroenterology,Vol. 110,No. 5,p. 741-752,2013年05月,書評論文,書評,文献紹介等
  • 細胞外ATPによるマウス腸管固有粘膜層におけるTh17細胞誘導,西村 潤一,竹田 潔,荻野 崇之,植村 守,竹政 伊知朗,水島 恒和,池田 正孝,石井 秀始,山本 浩文,関本 貢嗣,土岐 祐一郎,森 正樹,Cytometry Research,(一社)日本サイトメトリー学会,Vol. 23,No. 1,p. 29-31,2013年03月
  • 自然免疫系を標的とした炎症性腸疾患の制御 (特集 最新の免疫学 : 自然免疫・獲得免疫),梅本 英司,香山 尚子,竹田 潔,医薬ジャーナル,医薬ジャーナル社,Vol. 49,No. 2,p. 79-84,2013年02月
  • Wnt5aノックアウトマウスにおける腸管炎症の抑制,佐藤朗,庄嶋健作,香山尚子,小山浩史,竹田潔,菊池章,日本分子生物学会年会プログラム・要旨集(Web),Vol. 36th,2013年
  • Regulation of intestinal homeostasis by innate and adaptive immunity,Hisako Kayama,Kiyoshi Takeda,INTERNATIONAL IMMUNOLOGY,OXFORD UNIV PRESS,Vol. 24,No. 11,p. 673-680,2012年11月,書評論文,書評,文献紹介等
  • Innate immune effectors in mycobacterial infection,Kiyoshi Takeda,Hiroyuki Saiga,Yosuke Shimada,Clinical and Developmental Immunology,Vol. 2011,2011年,書評論文,書評,文献紹介等
  • The innate immune response to Trypanosoma cruzi infection,Hisako Kayama,Kiyoshi Takeda,MICROBES AND INFECTION,ELSEVIER SCIENCE BV,Vol. 12,No. 7,p. 511-517,2010年07月,書評論文,書評,文献紹介等
  • Current views of toll-like receptor signaling pathways,Kiyoshi Takeda,Masahiro Yamamoto,Gastroenterology Research and Practice,2010年,書評論文,書評,文献紹介等
  • Increased atherosclerotic lesions and Th17 in interleukin-18 deficient apolipoprotein E-knockout mice fed high-fat diet,Nada Pejnovic,Athanassios Vratimos,Sang Hee Lee,Dusan Popadic,Kiyoshi Takeda,Shizuo Akira,Woon Ling Chan,Molecular Immunology,Vol. 47,No. 1,p. 37-45,2009年11月,書評論文,書評,文献紹介等
  • The study of innate immunity in Japan: a historical perspective,Tsuneyasu Kaisho,Kiyoshi Takeda,INTERNATIONAL IMMUNOLOGY,OXFORD UNIV PRESS,Vol. 21,No. 4,p. 313-316,2009年04月,書評論文,書評,文献紹介等
  • Regulatory mechanisms of immune responses to intestinal bacteria,K. Honda,K. Takeda,Mucosal Immunology,Vol. 2,No. 3,p. 187-196,2009年,書評論文,書評,文献紹介等
  • Role of nuclear IκB proteins in the regulation of host immune responses,Masahiro Yamamoto,Kiyoshi Takeda,Journal of Infection and Chemotherapy,Springer Japan,Vol. 14,No. 4,p. 265-269,2008年,書評論文,書評,文献紹介等
  • TLRと炎症反応制御 (特集 自然免疫研究:TLRから次のステージへ),森下英晃,桑田啓貴,竹田潔,細胞工学,秀潤社,Vol. 25,No. 7,p. 769-772,2006年07月
  • Toll-like receptors and their adaptors in innate immunity,Kiyoshi Takeda,Current Medicinal Chemistry: Anti-Inflammatory and Anti-Allergy Agents,Vol. 4,No. 1,p. 3-11,2005年02月,書評論文,書評,文献紹介等
  • マウスstrawberry notch homologue遺伝子の解析,坂尾宣充,坂尾宣充,植松智,竹内理,竹内理,安居輝人,竹田潔,改正恒康,審良静男,審良静男,日本免疫学会総会・学術集会記録,Vol. 35,2005年
  • Toll-like receptors in innate immunity,Kiyoshi Takeda,Shizuo Akira,International Immunology,Vol. 17,No. 1,p. 1-14,2005年01月,書評論文,書評,文献紹介等
  • 免疫セマフォリン分子Sema4AのTh1/Th2制御における役割,識名 崇,熊ノ郷 淳,鈴木 一博,植松 智,筒井 ひろ子,審良 静男,竹田 潔,菊谷 仁,日本免疫学会総会・学術集会記録,(NPO)日本免疫学会,Vol. 34,p. 232-232,2004年11月
  • Microbial recognition by Toll-like receptors,Kiyoshi Takeda,Shizuo Akira,Journal of Dermatological Science,Vol. 34,No. 2,p. 73-82,2004年04月,書評論文,書評,文献紹介等
  • Stimulation of human Toll-like receptor (TLR) 2 and TLR6 with membrane lipoproteins of Mycoplasma fermentans induces apoptotic cell death after NF-κB activation,Takeshi Into,Kazuto Kiura,Motoaki Yasuda,Hideo Kataoka,Nobuo Inoue,Akira Hasebe,Kiyoshi Takeda,Shizuo Akira,Ken-Ichiro Shibata,Cellular Microbiology,Vol. 6,No. 2,p. 187-199,2004年02月,書評論文,書評,文献紹介等
  • RIG-I欠損マウスの作成および解析,加藤博己,佐藤慎太郎,山本雅裕,松井孝介,植松智,竹田潔,竹内理,審良静男,日本免疫学会総会・学術集会記録,Vol. 34,2004年
  • Toll-like receptor signalling,Shizuo Akira,Kiyoshi Takeda,Nature Reviews Immunology,Nature Publishing Group,Vol. 4,No. 7,p. 499-511,2004年,書評論文,書評,文献紹介等
  • TLR signaling pathways,Kiyoshi Takeda,Shizuo Akira,Seminars in Immunology,Academic Press,Vol. 16,No. 1,p. 3-9,2004年,書評論文,書評,文献紹介等
  • TIR domain-containing adaptors define the specificity of TLR signaling,Masahiro Yamamoto,Kiyoshi Takeda,Shizuo Akira,Molecular Immunology,Elsevier Ltd,Vol. 40,No. 12,p. 861-868,2004年,書評論文,書評,文献紹介等
  • TRIFはTLRのMyD88非依存的経路を担うアダプター分子である,山本 雅裕,佐藤 慎太郎,辺見 弘明,改正 恒康,星野 克明,竹田 潔,審良 静男,日本免疫学会総会・学術集会記録,(NPO)日本免疫学会,Vol. 33,p. 122-122,2003年11月
  • TBK1/NAK/T2KはLPSによるIFN-inducible geneの発現に関与する,邊見 弘明,佐藤 慎太郎,山本 雅裕,改正 恒康,河合 太郎,星野 克明,竹田 潔,審良 静男,日本免疫学会総会・学術集会記録,(NPO)日本免疫学会,Vol. 33,p. 123-123,2003年11月
  • Toll-like receptor-mediated tyrosine phosphorylation of paxillin via MyD88-dependent and -independent pathways,Kaoru Hazeki,Naoyo Masuda,Kenji Funami,Naoe Sukenobu,Misako Matsumoto,Shizuo Akira,Kiyoshi Takeda,Tsukasa Seya,Osamu Hazeki,European Journal of Immunology,Vol. 33,No. 3,p. 740-747,2003年03月01日,書評論文,書評,文献紹介等
  • Toll receptors and pathogen resistance,Kiyoshi Takeda,Shizuo Akira,Cellular Microbiology,Vol. 5,No. 3,p. 143-153,2003年03月01日,書評論文,書評,文献紹介等
  • 消化器疾患と免疫 基礎 消化器疾患と自然免疫機構,植松智,竹田潔,審良静男,現代医療,Vol. 35,No. 11,2003年
  • Toll-like receptors,Kiyoshi Takeda,Tsuneyasu Kaisho,Shizuo Akira,Annual Review of Immunology,Vol. 21,p. 335-376,2003年,書評論文,書評,文献紹介等
  • Toll様レセプターと自然免疫 (免疫研究の最前線--高次複雑系免疫システムの包括的理解をめざして) -- (自然免疫系の認識と調節),竹田 潔,審良 静男,蛋白質核酸酵素,共立出版,Vol. 47,No. 16,p. 2097-2102,2002年12月
  • DNAマイクロアレイを用いたIL‐10の標的遺伝子の同定と機能解析,桑田啓貴,竹田潔,改正恒康,審良静男,日本免疫学会総会・学術集会記録,Vol. 32,2002年10月31日
  • 膜結合型PGE2合成酵素の発現様式とノックアウトマウスの解析,植松 智,松本 真琴,竹田 潔,審良 静男,日本免疫学会総会・学術集会記録,(NPO)日本免疫学会,Vol. 32,p. 37-37,2002年10月
  • TIRAP/MalはTLR4シグナルだけでなく,TLR2シグナルにも関わっている,山本 雅裕,佐藤 慎太郎,辺見 弘明,山条 秀樹,植松 智,改正 恒康,星野 克明,竹田 潔,審良 静男,日本免疫学会総会・学術集会記録,(NPO)日本免疫学会,Vol. 32,p. 38-38,2002年10月
  • マクロファージにおけるIL-10の標的遺伝子の同定と機能解析,坂尾 宣充,竹田 潔,植松 智,審良 静男,日本免疫学会総会・学術集会記録,(NPO)日本免疫学会,Vol. 31,p. 238-238,2001年12月
  • Toll-like receptorとinnate immunity (特集 Innate immunity--基礎と臨床) -- (基礎),竹田 潔,審良 静男,現代医療,現代医療社,Vol. 33,No. 4,p. 917-923,2001年
  • Regulation of innate immune responses by toll-like receptors,Kiyoshi Takeda,Shizuo Akira,Japanese Journal of Infectious Diseases,Vol. 54,No. 6,p. 209-219,2001年,書評論文,書評,文献紹介等
  • Multi-functional roles of stat3 revealed by conditional gene targeting,Kiyoshi Takeda,Shizuo Akira,Archivum Immunologiae et Therapiae Experimentalis,Vol. 49,No. 4,p. 279-283,2001年,書評論文,書評,文献紹介等
  • Toll-like receptors: Critical proteins linking innate and acquired immunity,Shizuo Akira,Kiyoshi Takeda,Tsuneyasu Kaisho,Nature Immunology,Vol. 2,No. 8,p. 675-680,2001年,書評論文,書評,文献紹介等
  • Roles of Toll-like receptors in innate immune responses,K. Takeda,S. Akira,Genes to Cells,Vol. 6,No. 9,p. 733-742,2001年,書評論文,書評,文献紹介等
  • マクロファージにおけるIL-10の標的遺伝子の同定,坂尾 宣充,竹田 潔,松本 真琴,横山 清司,植松 智,審良 静男,日本免疫学会総会・学術集会記録,(NPO)日本免疫学会,Vol. 30,p. 76-76,2000年11月
  • λ-カラゲナンにより誘導される炎症反応はToll like receptor 4(TLR4)を介する,星野 克明,辻 亮平,Nowak Bernadeta,竹田 潔,改正 恒康,審良 静男,日本免疫学会総会・学術集会記録,(NPO)日本免疫学会,Vol. 30,p. 70-70,2000年11月
  • STAT family of transcription factors in cytokine-mediated biological responses,Kiyoshi Takeda,Shizuo Akira,Cytokine and Growth Factor Reviews,Vol. 11,No. 3,p. 199-207,2000年09月01日,書評論文,書評,文献紹介等
  • 免疫疾患と転写因子 (特集 転写因子と疾患--基礎と臨床),竹田 潔,審良 静男,現代医療,現代医療社,Vol. 32,No. 2,p. 441-447,2000年02月
  • STAT6: Its role in interleukin 4-mediated biological functions,Kiyoshi Takeda,Tadamitsu Kishimoto,Shizuo Akira,Journal of Molecular Medicine,Vol. 75,No. 5,p. 317-326,1997年,書評論文,書評,文献紹介等