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Discovery and development of an oral analgesic targeting the α2B adrenoceptor.
Masayasu Toyomoto, Takashi Kurihara, Takayuki Nakagawa, Asuka Inoue, Ryo Kimura, Isao Kii, Teruo Sawada, Takashi Ogihara, Kazuki Nagayasu, Takayuki Kishi, Hiroshi Onogi, Dohyun Im, Hidetsugu Asada, So Iwata, Jumpei Taguchi, Yuto Sumida, Suguru Yoshida, Junken Aoki, Takamitsu Hosoya, Masatoshi Hagiwara
Proceedings of the National Academy of Sciences of the United States of America Vol. 122 No. 32 2025年8月12日 研究論文（学術雑誌）
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Comparison of the Sensory Profile Among Autistic Individuals and Individuals with Williams Syndrome.
Masahiro Hirai, Ayaka Ikeda, Takeo Kato, Takahiro Ikeda, Kosuke Asada, Yoko Hakuno, Kanae Matsushima, Tomonari Awaya, Shin Okazaki, Toshihiro Kato, Toshio Heike, Masatoshi Hagiwara, Takanori Yamagata, Kiyotaka Tomiwa, Ryo Kimura
Journal of autism and developmental disorders Vol. 55 p. 2092-2099 2025年6月 研究論文（学術雑誌）
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Comparison of the Social Responsiveness Scale-2 among Individuals with Autism Spectrum Disorder and Williams Syndrome in Japan
Masahiro Hirai, Kosuke Asada, Takeo Kato, Takahiro Ikeda, Yoko Hakuno, Ayaka Ikeda, Kanae Matsushima, Tomonari Awaya, Shin Okazaki, Toshihiro Kato, Yasuko Funabiki, Toshiya Murai, Toshio Heike, Masatoshi Hagiwara, Takanori Yamagata, Kiyotaka Tomiwa, Ryo Kimura
Journal of Autism and Developmental Disorders Vol. 54 No. 8 p. 3176-3184 2024年8月 研究論文（学術雑誌）
出版者・発行元：Springer Science and Business Media LLC
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Association between copy number variations in parkin (PRKN) and schizophrenia and autism spectrum disorder: A case–control study
Tzuyao Lo, Itaru Kushima, Hiroki Kimura, Branko Aleksic, Takashi Okada, Hidekazu Kato, Toshiya Inada, Yoshihiro Nawa, Youta Torii, Maeri Yamamoto, Ryo Kimura, Yasuko Funabiki, Hirotaka Kosaka, Shusuke Numata, Kiyoto Kasai, Tsukasa Sasaki, Shigeru Yokoyama, Toshio Munesue, Ryota Hashimoto, Yuka Yasuda, Michiko Fujimoto, Masahide Usami, Masanari Itokawa, Makoto Arai, Kazutaka Ohi, Toshiyuki Someya, Yuichiro Watanabe, Jun Egawa, Tsutomu Takahashi, Michio Suzuki, Hidenori Yamasue, Nakao Iwata, Masashi Ikeda, Norio Ozaki
Neuropsychopharmacology Reports Vol. 44 No. 1 p. 42-50 2024年3月 研究論文（学術雑誌）
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Epigenetic aging in Williams syndrome
Satoshi Okazaki, Ryo Kimura, Ikuo Otsuka, Kiyotaka Tomiwa, Yasuko Funabiki, Masatoshi Hagiwara, Toshiya Murai, Akitoyo Hishimoto
Journal of Child Psychology and Psychiatry Vol. 63 No. 12 p. 1553-1562 2022年4月13日 研究論文（学術雑誌）
出版者・発行元：Wiley
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Cross-disorder analysis of genic and regulatory copy number variations in bipolar disorder, schizophrenia, and autism spectrum disorder
Itaru Kushima, Masahiro Nakatochi, Branko Aleksic, Takashi Okada, Hiroki Kimura, Hidekazu Kato, Mako Morikawa, Toshiya Inada, Kanako Ishizuka, Youta Torii, Yukako Nakamura, Satoshi Tanaka, Miho Imaeda, Nagahide Takahashi, Maeri Yamamoto, Kunihiro Iwamoto, Yoshihiro Nawa, Nanayo Ogawa, Shuji Iritani, Yu Hayashi, Tzuyao Lo, Gantsooj Otgonbayar, Sho Furuta, Nakao Iwata, Masashi Ikeda, Takeo Saito, Kohei Ninomiya, Tomo Okochi, Ryota Hashimoto, Hidenaga Yamamori, Yuka Yasuda, Michiko Fujimoto, Kenichiro Miura, Masanari Itokawa, Makoto Arai, Mitsuhiro Miyashita, Kazuya Toriumi, Kazutaka Ohi, Toshiki Shioiri, Kiyoyuki Kitaichi, Toshiyuki Someya, Yuichiro Watanabe, Jun Egawa, Tsutomu Takahashi, Michio Suzuki, Tsukasa Sasaki, Mamoru Tochigi, Fumichika Nishimura, Hidenori Yamasue, Hitoshi Kuwabara, Tomoyasu Wakuda, Takahiro A. Kato, Shigenobu Kanba, Hideki Horikawa, Masahide Usami, Masaki Kodaira, Kyota Watanabe, Takeo Yoshikawa, Tomoko Toyota, Shigeru Yokoyama, Toshio Munesue, Ryo Kimura, Yasuko Funabiki, Hirotaka Kosaka, Minyoung Jung, Kiyoto Kasai, Tempei Ikegame, Seiichiro Jinde, Shusuke Numata, Makoto Kinoshita, Tadafumi Kato, Chihiro Kakiuchi, Kazuhiro Yamakawa, Toshimitsu Suzuki, Naoki Hashimoto, Shuhei Ishikawa, Bun Yamagata, Shintaro Nio, Toshiya Murai, Shuraku Son, Yasuto Kunii, Hirooki Yabe, Masumi Inagaki, Yu-ichi Goto, Yuto Okumura, Tomoya Ito, Yuko Arioka, Daisuke Mori, Norio Ozaki
Biological Psychiatry Vol. 92 No. 5 p. 362-374 2022年4月 研究論文（学術雑誌）
出版者・発行元：Elsevier BV
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Epigenetic clock analysis and increased plasminogen activator inhibitor-1 in high-functioning autism spectrum disorder
Satoshi Okazaki, Ryo Kimura, Ikuo Otsuka, Yasuko Funabiki, Toshiya Murai, Akitoyo Hishimoto
PLOS ONE Vol. 17 No. 2 p. e0263478-e0263478 2022年2月3日 研究論文（学術雑誌）
出版者・発行元：Public Library of Science (PLoS)
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Rare genetic variants in the gene encoding histone lysine demethylase 4C (KDM4C) and their contributions to susceptibility to schizophrenia and autism spectrum disorder.
Hidekazu Kato, Itaru Kushima, Daisuke Mori, Akira Yoshimi, Branko Aleksic, Yoshihiro Nawa, Miho Toyama, Sho Furuta, Yanjie Yu, Kanako Ishizuka, Hiroki Kimura, Yuko Arioka, Keita Tsujimura, Mako Morikawa, Takashi Okada, Toshiya Inada, Masahiro Nakatochi, Keiko Shinjo, Yutaka Kondo, Kozo Kaibuchi, Yasuko Funabiki, Ryo Kimura, Toshimitsu Suzuki, Kazuhiro Yamakawa, Masashi Ikeda, Nakao Iwata, Tsutomu Takahashi, Michio Suzuki, Yuko Okahisa, Manabu Takaki, Jun Egawa, Toshiyuki Someya, Norio Ozaki
Translational psychiatry Vol. 10 No. 1 p. 421-421 2020年12月5日 研究論文（学術雑誌）
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Different effects of methylphenidate and atomoxetine on the behavior and brain transcriptome of zebrafish.
Shiho Suzuki, Ryo Kimura, Shingo Maegawa, Masatoshi Nakata, Masatoshi Hagiwara
Molecular brain Vol. 13 No. 1 p. 70-70 2020年5月6日 研究論文（学術雑誌）
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Integrated DNA methylation analysis reveals a potential role for ANKRD30B in Williams syndrome.
Ryo Kimura, Roy Lardenoije, Kiyotaka Tomiwa, Yasuko Funabiki, Masatoshi Nakata, Shiho Suzuki, Tomonari Awaya, Takeo Kato, Shin Okazaki, Toshiya Murai, Toshio Heike, Bart P F Rutten, Masatoshi Hagiwara
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology Vol. 45 No. 10 p. 1627-1636 2020年4月18日 研究論文（学術雑誌）
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Dysregulation of the oxytocin receptor gene in Williams syndrome.
Ryo Kimura, Kiyotaka Tomiwa, Ryo Inoue, Shiho Suzuki, Masatoshi Nakata, Tomonari Awaya, Takeo Kato, Shin Okazaki, Toshio Heike, Masatoshi Hagiwara
Psychoneuroendocrinology Vol. 115 p. 104631-104631 2020年2月20日 研究論文（学術雑誌）
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MicroRNA profiling in adults with high-functioning autism spectrum disorder.
Nakata M, Kimura R, Funabiki Y, Awaya T, Murai T, Hagiwara M
Molecular Brain Vol. 12 No. 1 p. 82-82 2019年10月 研究論文（学術雑誌）
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An epigenetic biomarker for adult high-functioning autism spectrum disorder.
Kimura R, Nakata M, Funabiki Y, Suzuki S, Awaya T, Murai T, Hagiwara M
Scientific reports Vol. 9 No. 1 p. 13662-13662 2019年9月 研究論文（学術雑誌）
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Integrative network analysis reveals biological pathways associated with Williams syndrome
Ryo Kimura, Vivek Swarup, Kiyotaka Tomiwa, Michael J. Gandal, Neelroop N. Parikshak, Yasuko Funabiki, Masatoshi Nakata, Tomonari Awaya, Takeo Kato, Kei Iida, Shin Okazaki, Kanae Matsushima, Toshihiro Kato, Toshiya Murai, Toshio Heike, Daniel H. Geschwind, Masatoshi Hagiwara
Journal of Child Psychology and Psychiatry Vol. 60 No. 5 p. 585-598 2019年5月 研究論文（学術雑誌）
出版者・発行元：Wiley
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Robust candidates for language development and evolution are significantly dysregulated in the blood of people with Williams syndrome
Benítez-Burraco A, Kimura R
Frontiers in Neuroscience Vol. 13 2019年3月 研究論文（学術雑誌）
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Comparative Analyses of Copy-Number Variation in Autism Spectrum Disorder and Schizophrenia Reveal Etiological Overlap and Biological Insights.
Itaru Kushima, Branko Aleksic, Masahiro Nakatochi, Teppei Shimamura, Takashi Okada, Yota Uno, Mako Morikawa, Kanako Ishizuka, Tomoko Shiino, Hiroki Kimura, Yuko Arioka, Akira Yoshimi, Yuto Takasaki, Yanjie Yu, Yukako Nakamura, Maeri Yamamoto, Tetsuya Iidaka, Shuji Iritani, Toshiya Inada, Nanayo Ogawa, Emiko Shishido, Youta Torii, Naoko Kawano, Yutaka Omura, Toru Yoshikawa, Tokio Uchiyama, Toshimichi Yamamoto, Masashi Ikeda, Ryota Hashimoto, Hidenaga Yamamori, Yuka Yasuda, Toshiyuki Someya, Yuichiro Watanabe, Jun Egawa, Ayako Nunokawa, Masanari Itokawa, Makoto Arai, Mitsuhiro Miyashita, Akiko Kobori, Michio Suzuki, Tsutomu Takahashi, Masahide Usami, Masaki Kodaira, Kyota Watanabe, Tsukasa Sasaki, Hitoshi Kuwabara, Mamoru Tochigi, Fumichika Nishimura, Hidenori Yamasue, Yosuke Eriguchi, Seico Benner, Masaki Kojima, Walid Yassin, Toshio Munesue, Shigeru Yokoyama, Ryo Kimura, Yasuko Funabiki, Hirotaka Kosaka, Makoto Ishitobi, Tetsuro Ohmori, Shusuke Numata, Takeo Yoshikawa, Tomoko Toyota, Kazuhiro Yamakawa, Toshimitsu Suzuki, Yushi Inoue, Kentaro Nakaoka, Yu-Ichi Goto, Masumi Inagaki, Naoki Hashimoto, Ichiro Kusumi, Shuraku Son, Toshiya Murai, Tempei Ikegame, Naohiro Okada, Kiyoto Kasai, Shohko Kunimoto, Daisuke Mori, Nakao Iwata, Norio Ozaki
Cell reports Vol. 24 No. 11 p. 2838-2856 2018年9月11日 研究論文（学術雑誌）
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Williams-Beuren syndrome as a potential risk factor for Burkitt lymphoma.
Kimura R, Ishii Y, Tomiwa K, Awaya T, Nakata M, Kato T, Okazaki S, Heike T, Hagiwara M
Frontiers in Genetics Vol. 9 p. 368-368 2018年8月 研究論文（学術雑誌）
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A Skeletal Muscle Model of Infantile-onset Pompe Disease with Patient-specific iPS Cells
Takeshi Yoshida, Tomonari Awaya, Tatsuya Jonouchi, Ryo Kimura, Shigemi Kimura, Takumi Era, Toshio Heike, Hidetoshi Sakurai
SCIENTIFIC REPORTS Vol. 7 No. 1 2017年10月 研究論文（学術雑誌）
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Transcriptome analysis of distinct mouse strains reveals kinesin light chain-1 splicing as an amyloid-β accumulation modifier.
Morihara T, Hayashi N, Yokokoji M, Akatsu H, Silverman MA, Kimura N, Sato M, Saito Y, Suzuki T, Yanagida K, Kodama TS, Tanaka T, Okochi M, Tagami S, Kazui H, Kudo T, Hashimoto R, Itoh N, Nishitomi K, Yamaguchi-Kabata Y, Tsunoda T, Takamura H, Katayama T, Kimura R, Kamino K, Hashizume Y, Takeda M
Proceedings of the National Academy of Sciences of the United States of America Vol. 111 No. 7 p. 2638-2643 2014年2月 研究論文（学術雑誌）
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Comparison of the clinical features of suicide attempters by jumping from a height and those by self-stabbing in Japan.
Ryo Kimura, Shunichiro Ikeda, Hirokazu Kumazaki, Makoto Yanagida, Hidenori Matsunaga
Journal of affective disorders Vol. 150 No. 2 p. 695-8 2013年9月5日 研究論文（学術雑誌）
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A 73-year-old patient with adult-onset type II citrullinemia successfully treated by sodium pyruvate and arginine
Masahide Yazaki, Michiaki Kinoshita, Shinji Ogawa, Satoshi Fujimi, Akira Matsushima, Akiyo Hineno, Ko-ichi Tazawa, Kazuhiro Fukushima, Ryo Kimura, Makoto Yanagida, Hidenori Matsunaga, Takeyori Saheki, Shu-ichi Ikeda
CLINICAL NEUROLOGY AND NEUROSURGERY Vol. 115 No. 8 p. 1542-1545 2013年8月 研究論文（学術雑誌）
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The effects of memantine on a patient having preclinical dementia with Lewy bodies
Masahiko Takaya, Kazuyo Matsusaka, Makoto Yanagida, Ryo Kimura, Hidenori Matsunaga
GENERAL HOSPITAL PSYCHIATRY Vol. 35 No. 3 2013年5月
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Treatment of delirium with ramelteon: initial experience in three patients
Ryo Kimura, Kohji Mori, Hirokazu Kumazaki, Makoto Yanagida, Satoki Taguchi, Hidenori Matsunaga
GENERAL HOSPITAL PSYCHIATRY Vol. 33 No. 4 p. 407-409 2011年7月 研究論文（学術雑誌）
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Association between CAG repeat length in the PPP2R2B gene and Alzheimer disease in the Japanese population
Ryo Kimura, Takashi Morihara, Takashi Kudo, Kouzin Kamino, Masatoshi Takeda
NEUROSCIENCE LETTERS Vol. 487 No. 3 p. 354-357 2011年1月 研究論文（学術雑誌）
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Meta-analysis of the Association Between Variants in SORL1 and Alzheimer Disease
Christiane Reitz, Rong Cheng, Ekaterina Rogaeva, Joseph H. Lee, Shinya Tokuhiro, Fanggeng Zou, Karolien Bettens, Kristel Sleegers, Eng King Tan, Ryo Kimura, Nobuto Shibata, Heii Arai, M. Ilyas Kamboh, Jonathan A. Prince, Wolfgang Maier, Matthias Riemenschneider, Michael Owen, Denise Harold, Paul Hollingworth, Elena Cellini, Sandro Sorbi, Benedetta Nacmias, Masatoshi Takeda, Margaret A. Pericak-Vance, Jonathan L. Haines, Steven Younkin, Julie Williams, Christine van Broeckhoven, Lindsay A. Farrer, Peter H. St George-Hyslop, Richard Mayeux
ARCHIVES OF NEUROLOGY Vol. 68 No. 1 p. 99-106 2011年1月 研究論文（学術雑誌）
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Posterior reversible encephalopathy syndrome in chronic alcoholism with acute psychiatric symptoms
Ryo Kimura, Makoto Yanagida, Aki Kugo, Satoki Taguchi, Hidenori Matsunaga
General Hospital Psychiatry Vol. 32 No. 4 p. 447-e5 2010年7月 研究論文（学術雑誌）
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KIBRA Genetic Polymorphism Influences Episodic Memory in Alzheimer's Disease, but Does Not Show Association with Disease in a Japanese Cohort
Noriyuki Hayashi, Hiroaki Kazui, Kouzin Kamino, Hiromasa Tokunaga, Masahiko Takaya, Mikiko Yokokoji, Ryo Kimura, Yumiko Kito, Tamiki Wada, Keiko Nomura, Hiromichi Sugiyama, Daisuke Yamamoto, Tetsuhiko Yoshida, Antonio Currais, Salvador Soriano, Toshimitsu Hamasaki, Mitsuko Yamamoto, Yuka Yasuda, Ryota Hashimoto, Hitoshi Tanimukai, Shinji Tagami, Masayasu Okochi, Toshihisa Tanaka, Takashi Kudo, Takashi Morihara, Masatoshi Takeda
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS Vol. 30 No. 4 p. 302-308 2010年 研究論文（学術雑誌）
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SORL1 is genetically associated with Alzheimer disease in a Japanese population
Ryo Kimura, Mitsuko Yamamoto, Takashi Morihara, Hiroyasu Akatsu, Takashi Kudo, Kouzin Kamino, Masatoshi Takeda
NEUROSCIENCE LETTERS Vol. 461 No. 2 p. 177-180 2009年9月 研究論文（学術雑誌）
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Decrease of dynamin 2 levels in late-onset Alzheimer\\'s disease alters Aβ metabolism
E. Kamagata, T. Kudo, R. Kimura, H. Tanimukai, T. Morihara, Md.G. Sadik, K. Kamino, M. Takeda
Biochemical and Biophysical Research Communications Vol. 379 No. 3 p. 691-695 2009年2月 研究論文（学術雑誌）
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Dynamin 2 gene is a novel susceptibility gene for late-onset Alzheimer disease in non-APOE-ε4 carriers
N.J. Aidaralieva, K. Kamino, R. Kimura, M. Yamamoto, T. Morihara, H. Kazui, R. Hashimoto, T. Tanaka, T. Kudo, T. Kida, J.-I. Okuda, T. Uema, H. Yamagata, T. Miki, H. Akatsu, K. Kosaka, M. Takeda
Journal of Human Genetics Vol. 53 No. 4 p. 296-302 2008年4月 研究論文（学術雑誌）
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A molecular chaperone inducer protects neurons from ER stress
T. Kudo, S. Kanemoto, H. Hara, N. Morimoto, T. Morihara, R. Kimura, T. Tabira, K. Imaizumi, M. Takeda
CELL DEATH AND DIFFERENTIATION Vol. 15 No. 2 p. 364-375 2008年2月 研究論文（学術雑誌）
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The DYRK1A gene, encoded in chromosome 21 Down syndrome critical region, bridges between β-amyloid production and tau phosphorylation in Alzheimer disease
R. Kimura, K. Kamino, M. Yamamoto, A. Nuripa, T. Kida, H. Kazui, R. Hashimoto, T. Tanaka, T. Kudo, H. Yamagata, Y. Tabara, T. Miki, H. Akatsu, K. Kosaka, E. Funakoshi, K. Nishitomi, G. Sakaguchi, A. Kato, H. Hattori, T. Uema, M. Takeda
Human Molecular Genetics Vol. 16 No. 1 p. 15-23 2007年1月 研究論文（学術雑誌）
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Aβ induces endoplasmic reticulum stress causing possible proteasome impairment via the endoplasmic reticulum-associated degradation pathway
D. Kanayama, T. Kudo, R. Kimura, N. Tabuchi, A. Fukumori, T. Morihara, S. Tagami, H. Tanii, M. Okochi, K. Kamino, T. Tanaka, K. Imaizumi, T. Tabira, M. Takeda
Psychogeriatrics Vol. 6 No. 3 p. 100-106 2006年9月 研究論文（学術雑誌）
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Altered localization of amyloid precursor protein under endoplasmic reticulum stress
T Kudo, M Okumura, K Imaizumi, W Araki, T Morlhara, H Tanimukal, E Kamagata, N Tabuchi, R Kimura, D Kanayama, A Fukumori, S Tagami, M Okochi, M Kubo, H Tanii, M Tohyama, T Tabira, M Takeda
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Vol. 344 No. 2 p. 525-530 2006年6月 研究論文（学術雑誌）
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Albumin gene encoding free fatty acid and beta-amyloid transporter is genetically associated with Alzheimer disease
R Kimura, K Kamino, M Yamamoto, T Kida, H Akatsu, T Uema, T Kobayashi, H Hattori, A Nuripa, BN Nessa, H Kazui, Y Ikejiri, T Tanaka, H Tanii, T Kudo, H Yoneda, H Yamagata, T Miki, M Takeda
PSYCHIATRY AND CLINICAL NEUROSCIENCES Vol. 60 p. S34-S39 2006年4月 研究論文（学術雑誌）
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Toll-like receptor 3 mediated hyperphosphorylation of tau in human SH-SY5Y neuroblastoma cells
BN Nessa, T Tanaka, K Kamino, G Sadik, MA Bin Ansar, R Kimura, H Tanii, M Okochi, T Morihara, S Tagami, T Kudo, M Takeda
PSYCHIATRY AND CLINICAL NEUROSCIENCES Vol. 60 p. S27-S33 2006年4月 研究論文（学術雑誌）
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Secretion of the Notch-1 Aβ-like peptide during Notch signaling
M. Okochi, A. Fukumori, J. Jiang, N. Itoh, R. Kimura, H. Steiner, C. Haass, S. Tagami, M. Takeda
Journal of Biological Chemistry Vol. 281 No. 12 p. 7890-7898 2006年3月 研究論文（学術雑誌）
