Genomic diversity of SARS-CoV-2 can be accelerated by mutations in the nsp14 gene

Kosuke Takada, Mahoko Takahashi Ueda, Shintaro Shichinohe, Yurie Kida, Chikako Ono, Yoshiharu Matsuura, Tokiko Watanabe, So Nakagawa

iScience　Vol. 26　No. 3　p. 106210-106210　2023年3月1日　研究論文（学術雑誌）

Inactivated whole influenza virus particle vaccines induce neutralizing antibodies with an increase in immunoglobulin gene subclones of B-lymphocytes in cynomolgus macaques.

Masanori Shiohara, Saori Suzuki, Shintaro Shichinohe, Hirohito Ishigaki, Misako Nakayama, Naoki Nomura, Masashi Shingai, Toshiki Sekiya, Marumi Ohno, Sayaka Iida, Naoko Kawai, Mamiko Kawahara, Junya Yamagishi, Kimihito Ito, Ryotarou Mitsumata, Tomio Ikeda, Kenji Motokawa, Tomoyoshi Sobue, Hiroshi Kida, Kazumasa Ogasawara, Yasushi Itoh

Vaccine　Vol. 40　No. 30　p. 4026-4037　2022年6月26日　研究論文（学術雑誌）

SARS-CoV-2 infection triggers paracrine senescence and leads to a sustained senescence-associated inflammatory response

Shunya Tsuji, Shohei Minami, Rina Hashimoto, Yusuke Konishi, Tatsuya Suzuki, Tamae Kondo, Miwa Sasai, Shiho Torii, Chikako Ono, Shintaro Shichinohe, Shintaro Sato, Masahiro Wakita, Shintaro Okumura, Sosuke Nakano, Tatsuyuki Matsudaira, Tomonori Matsumoto, Shimpei Kawamoto, Masahiro Yamamoto, Tokiko Watanabe, Yoshiharu Matsuura, Kazuo Takayama, Takeshi Kobayashi, Toru Okamoto, Eiji Hara

Nature Aging　Vol. 2　No. 2　p. 115-124　2022年2月1日

Macrocyclic peptides exhibit antiviral effects against influenza virus HA and prevent pneumonia in animal models.

Makoto Saito, Yasushi Itoh, Fumihiko Yasui, Tsubasa Munakata, Daisuke Yamane, Makoto Ozawa, Risa Ito, Takayuki Katoh, Hirohito Ishigaki, Misako Nakayama, Shintaro Shichinohe, Kenzaburo Yamaji, Naoki Yamamoto, Ai Ikejiri, Tomoko Honda, Takahiro Sanada, Yoshihiro Sakoda, Hiroshi Kida, Thi Quynh Mai Le, Yoshihiro Kawaoka, Kazumasa Ogasawara, Kyoko Tsukiyama-Kohara, Hiroaki Suga, Michinori Kohara

Nature communications　Vol. 12　No. 1　p. 2654-2654　2021年5月11日　研究論文（学術雑誌）

Low replicative fitness of neuraminidase inhibitor-resistant H7N9 avian influenza a virus with R292K substitution in neuraminidase in cynomolgus macaques compared with I222T substitution

Saori Suzuki, Shintaro Shichinohe, Yasushi Itoh, Misako Nakayama, Hirohito Ishigaki, Yuya Mori, Ayako Ogata-Nakahara, Cong Thanh Nguyen, Masatoshi Okamatsu, Yoshihiro Sakoda, Hiroshi Kida, Kazumasa Ogasawara

Antiviral Research　Vol. 178　p. 104790-104790　2020年6月　研究論文（学術雑誌）

Efficacy of clarithromycin against H5N1 and H7N9 avian influenza a virus infection in cynomolgus monkeys

Masahiko Arikata, Yasushi Itoh, Shintaro Shichinohe, Misako Nakayama, Hirohito Ishigaki, Takaaki Kinoshita, Mai Quynh Le, Yoshihiro Kawaoka, Kazumasa Ogasawara, Takeshi Shimizu

Antiviral Research　Vol. 171　2019年11月　研究論文（学術雑誌）

Selection of antigenic variants of an H5N1 highly pathogenic avian influenza virus in vaccinated chickens

Lam Thanh Nguyen, Tatsuya Nishi, Shintaro Shichinohe, Duc Huy Chu, Takahiro Hiono, Keita Matsuno, Masatoshi Okamatsu, Hiroshi Kida, Yoshihiro Sakoda

Virology　Vol. 510　p. 252-261　2017年10月　研究論文（学術雑誌）

Potential risk of repeated nasal vaccination that induces allergic reaction with mucosal IgE and airway eosinophilic infiltration in cynomolgus macaques infected with H5N1 highly pathogenic avian influenza virus

Misako Nakayama, Yasushi Itoh, Shintaro Shichinohe, Rumi Nakabayashi, Hirohito Ishigaki, Yoshihiro Sakoda, Quynh Mai Le, Yoshihiro Kawaoka, Hiroshi Kida, Kazumasa Ogasawara

Vaccine　Vol. 35　No. 7　p. 1008-1017　2017年2月15日　研究論文（学術雑誌）

Sensitization with vaccinia virus encoding H5N1 hemagglutinin restores immune potential against H5N1 influenza virus.

Fumihiko Yasui, Yasushi Itoh, Ai Ikejiri, Masahiro Kitabatake, Nobuo Sakaguchi, Keisuke Munekata, Shintaro Shichinohe, Yukiko Hayashi, Hirohito Ishigaki, Misako Nakayama, Yoshihiro Sakoda, Hiroshi Kida, Kazumasa Ogasawara, Michinori Kohara

Scientific reports　Vol. 6　p. 37915-37915　2016年11月28日　研究論文（学術雑誌）

Comparison of pathogenicities of H7 avian influenza viruses via intranasal and conjunctival inoculation in cynomolgus macaques

Shintaro Shichinohe, Yasushi Itoh, Misako Nakayama, Hiroichi Ozaki, Kosuke Soda, Hirohito Ishigaki, Masatoshi Okamatsu, Yoshihiro Sakoda, Hiroshi Kida, Kazumasa Ogasawara

Virology　Vol. 493　p. 31-38　2016年6月1日　研究論文（学術雑誌）

カニクイザルを用いたインフルエンザワクチンによる免疫記憶に及ぼす免疫抑制剤の影響の解析

伊藤 靖, 仲山 美沙子, 石垣 宏仁, 小笠原 一誠, 七戸 新太郎

日本病理学会会誌　Vol. 105　No. 1　p. 365-365　2016年4月

Experimental infection of highly and low pathogenic avian influenza viruses to chickens, ducks, tree sparrows, jungle crows, and black rats for the evaluation of their roles in virus transmission

Takahiro Hiono, Masatoshi Okamatsu, Naoki Yamamoto, Kohei Ogasawara, Mayumi Endo, Saya Kuribayashi, Shintaro Shichinohe, Yurie Motohashi, Duc Huy Chu, Mizuho Suzuki, Takaya Ichikawa, Tatsuya Nishi, Yuri Abe, Keita Matsuno, Kazuyuki Tanaka, Tsutomu Tanigawa, Hiroshi Kida, Yoshihiro Sakoda

Veterinary Microbiology　Vol. 182　p. 108-115　2016年1月15日　研究論文（学術雑誌）

Genetic and antigenic characterization of H5 and H7 influenza viruses isolated from migratory water birds in Hokkaido, Japan and Mongolia from 2010 to 2014

Takahiro Hiono, Ayako Ohkawara, Kohei Ogasawara, Masatoshi Okamatsu, Tomokazu Tamura, Duc Huy Chu, Mizuho Suzuki, Saya Kuribayashi, Shintaro Shichinohe, Ayato Takada, Hirohito Ogawa, Reiko Yoshida, Hiroko Miyamoto, Naganori Nao, Wakako Furuyama, Junki Maruyama, Nao Eguchi, Gerelmaa Ulziibat, Bazarragchaa Enkhbold, Munkhduuren Shatar, Tserenjav Jargalsaikhan, Selenge Byambadorj, Batchuluun Damdinjav, Yoshihiro Sakoda, Hiroshi Kida

Virus Genes　Vol. 51　No. 1　p. 57-68　2015年8月29日　研究論文（学術雑誌）

Emergence of H7N9 influenza A virus resistant to neuraminidase inhibitors in nonhuman primates

Yasushi Itoh, Shintaro Shichinohe, Misako Nakayama, Manabu Igarashi, Akihiro Ishii, Hirohito Ishigaki, Hideaki Ishida, Naoko Kitagawa, Takako Sasamura, Masanori Shiohara, Michiko Doi, Hideaki Tsuchiya, Shinichiro Nakamura, Masatoshi Okamatsu, Yoshihiro Sakoda, Hiroshi Kida, Kazumasa Ogasawara

Antimicrobial Agents and Chemotherapy　Vol. 59　No. 8　p. 4962-4973　2015年8月1日　研究論文（学術雑誌）

Efficacy of repeated intravenous administration of peramivir against highly pathogenic avian influenza a (H5N1) virus in cynomolgus macaques

Mitsutaka Kitano, Yasushi Itoh, Hirohito Ishigaki, Misako Nakayama, Hideaki Ishida, Van Loi Pham, Masahiko Arikata, Shintaro Shichinohe, Hideaki Tsuchiya, Naoko Kitagawa, Masanori Kobayashi, Ryu Yoshida, Akihiko Sato, Quynh Mai Le, Yoshihiro Kawaoka, Kazumasa Ogasawara

Antimicrobial Agents and Chemotherapy　Vol. 58　No. 8　p. 4795-4803　2014年8月　研究論文（学術雑誌）

Potency of an inactivated influenza vaccine prepared from A/duck/Mongolia/119/2008 (H7N9) against the challenge with A/Anhui/1/2013 (H7N9)

Duc Huy Chu, Yoshihiro Sakoda, Tatsuya Nishi, Takahiro Hiono, Shintaro Shichinohe, Masatoshi Okamatsu, Hiroshi Kida

Vaccine　Vol. 32　No. 28　p. 3473-3479　2014年6月12日　研究論文（学術雑誌）

Protective Efficacy of Passive Immunization with Monoclonal Antibodies in Animal Models of H5N1 Highly Pathogenic Avian Influenza Virus Infection

Yasushi Itoh, Reiko Yoshida, Shintaro Shichinohe, Megumi Higuchi, Hirohito Ishigaki, Misako Nakayama, Van Loi Pham, Hideaki Ishida, Mitsutaka Kitano, Masahiko Arikata, Naoko Kitagawa, Yachiyo Mitsuishi, Kazumasa Ogasawara, Hideaki Tsuchiya, Takahiro Hiono, Masatoshi Okamatsu, Yoshihiro Sakoda, Hiroshi Kida, Mutsumi Ito, Le Quynh Mai, Yoshihiro Kawaoka, Hiroko Miyamoto, Mari Ishijima, Manabu Igarashi, Yasuhiko Suzuki, Ayato Takada

PLoS Pathogens　Vol. 10　No. 6　2014年6月　研究論文（学術雑誌）

Pathogenicity of Pandemic H1N1 Influenza A Virus in Immunocompromised Cynomolgus Macaques

Van Loi Pham, Misako Nakayama, Yasushi Itoh, Hirohito Ishigaki, Mitsutaka Kitano, Masahiko Arikata, Hideaki Ishida, Naoko Kitagawa, Shintaro Shichinohe, Masatoshi Okamatsu, Yoshihiro Sakoda, Hideaki Tsuchiya, Shinichiro Nakamura, Hiroshi Kida, Kazumasa Ogasawara

PLoS ONE　Vol. 8　No. 9　2013年9月23日　研究論文（学術雑誌）

Selection of H3 avian influenza viruses with SAα2,6Gal receptor specificity in pigs.

Shichinohe S, Okamatsu M, Sakoda Y, Kida H

Virology　Vol. 444　No. 1-2　p. 404-408　2013年9月　研究論文（学術雑誌）

Potency of an inactivated influenza vaccine prepared from a non-pathogenic H5N1 virus against a challenge with antigenically drifted highly pathogenic avian influenza viruses in chickens

Shintaro Shichinohe, Masatoshi Okamatsu, Naoki Yamamoto, Yu Noda, Yuka Nomoto, Takashi Honda, Noriyasu Takikawa, Yoshihiro Sakoda, Hiroshi Kida

Veterinary Microbiology　Vol. 164　No. 1-2　p. 39-45　2013年5月31日　研究論文（学術雑誌）

Protection against H5N1 highly pathogenic avian and pandemic (H1N1) 2009 influenza virus infection in cynomolgus monkeys by an inactivated H5N1 whole particle vaccine

Misako Nakayama, Shintaro Shichinohe, Yasushi Itoh, Hirohito Ishigaki, Mitsutaka Kitano, Masahiko Arikata, Van Loi Pham, Hideaki Ishida, Naoko Kitagawa, Masatoshi Okamatsu, Yoshihiro Sakoda, Takaya Ichikawa, Hideaki Tsuchiya, Shinichiro Nakamura, Quynh Mai Le, Mutsumi Ito, Yoshihiro Kawaoka, Hiroshi Kida, Kazumasa Ogasawara

PLoS ONE　Vol. 8　No. 12　2013年2月23日　研究論文（学術雑誌）

Efficacy of repeated intravenous injection of peramivir against influenza A (H1N1) 2009 virus infection in immunosuppressed mice

Antimicrobial Agents and Chemotherapy　Vol. 57　p. 2286-2294　2013年　研究論文（学術雑誌）

Characterization of H7N9 influenza A viruses isolated from humans

Tokiko Watanabe, Maki Kiso, Satoshi Fukuyama, Noriko Nakajima, Masaki Imai, Shinya Yamada, Shin Murakami, Seiya Yamayoshi, Kiyoko Iwatsuki-Horimoto, Yoshihiro Sakoda, Emi Takashita, Ryan McBride, Takeshi Noda, Masato Hatta, Hirotaka Imai, Dongming Zhao, Noriko Kishida, Masayuki Shirakura, Robert P. De Vries, Shintaro Shichinohe, Masatoshi Okamatsu, Tomokazu Tamura, Yuriko Tomita, Naomi Fujimoto, Kazue Goto, Hiroaki Katsura, Eiryo Kawakami, Izumi Ishikawa, Shinji Watanabe, Mutsumi Ito, Yuko Sakai-Tagawa, Yukihiko Sugita, Ryuta Uraki, Reina Yamaji, Amie J. Eisfeld, Gongxun Zhong, Shufang Fan, Jihui Ping, Eileen A. Maher, Anthony Hanson, Yuko Uchida, Takehiko Saito, Makoto Ozawa, Gabriele Neumann, Hiroshi Kida, Takato Odagiri, James C. Paulson, Hideki Hasegawa, Masato Tashiro, Yoshihiro Kawaoka

Nature　Vol. 501　No. 7468　p. 551-555　2013年　研究論文（学術雑誌）

Reintroduction of h5n1 highly pathogenic avian influenza virus by migratory water birds, causing poultry outbreaks in the 2010-2011 winter season in Japan

Yoshihiro Sakoda, Hiroshi Lto, Yuko Uchida, Masatoshi Okamatsu, Naoki Yamamoto, Kosuke Soda, Naoki Nomura, Saya Kuribayashi, Shintaro Shichinohe, Yuji Sunden, Takashi Umemura, Tatsufumi Usui, Hiroichi Ozaki, Tsuyoshi Yamaguchi, Toshiyuki Murase, Toshihiro Ito, Takehiko Saito, Ayato Takada, Hiroshi Kida

Journal of General Virology　Vol. 93　No. 3　p. 541-550　2012年3月　研究論文（学術雑誌）