Joint single-cell measurements of surface proteins, intracellular proteins and gene expression with icCITE-seq

Kelvin Y. Chen, Yusuke Takeshima, Andre L. Zorzetto-Fernandes, Katsuhiro Makino, Tatsuya Kibayashi, Mayu Hata, Kenji Ichiyama, Josh Croteau, Kevin Taylor, Shimon Sakaguchi

2025年1月14日

Quantification of escape from X chromosome inactivation with single-cell omics data reveals heterogeneity across cell types and tissues.

Yoshihiko Tomofuji, Ryuya Edahiro, Kyuto Sonehara, Yuya Shirai, Kian Hong Kock, Qingbo S Wang, Shinichi Namba, Jonathan Moody, Yoshinari Ando, Akari Suzuki, Tomohiro Yata, Kotaro Ogawa, Tatsuhiko Naito, Ho Namkoong, Quy Xiao Xuan Lin, Eliora Violain Buyamin, Le Min Tan, Radhika Sonthalia, Kyung Yeon Han, Hiromu Tanaka, Ho Lee, Tatsusada Okuno, Boxiang Liu, Koichi Matsuda, Koichi Fukunaga, Hideki Mochizuki, Woong-Yang Park, Kazuhiko Yamamoto, Chung-Chau Hon, Jay W Shin, Shyam Prabhakar, Atsushi Kumanogoh, Yukinori Okada

Cell genomics　Vol. 4　No. 8　p. 100625-100625　2024年8月14日　研究論文（学術雑誌）

Single-cell transcriptome landscape of circulating CD4+ T cell populations in autoimmune diseases

Yoshiaki Yasumizu, Daiki Takeuchi, Reo Morimoto, Yusuke Takeshima, Tatsusada Okuno, Makoto Kinoshita, Takayoshi Morita, Yasuhiro Kato, Min Wang, Daisuke Motooka, Daisuke Okuzaki, Yamami Nakamura, Norihisa Mikami, Masaya Arai, Xuan Zhang, Atsushi Kumanogoh, Hideki Mochizuki, Naganari Ohkura, Shimon Sakaguchi

Cell Genomics　p. 100473-100473　2024年1月　研究論文（学術雑誌）

Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity

Ryuya Edahiro, Yuya Shirai, Yusuke Takeshima, Shuhei Sakakibara, Yuta Yamaguchi, Teruaki Murakami, Takayoshi Morita, Yasuhiro Kato, Yu-Chen Liu, Daisuke Motooka, Yoko Naito, Ayako Takuwa, Fuminori Sugihara, Kentaro Tanaka, James B. Wing, Kyuto Sonehara, Yoshihiko Tomofuji, Qingbo S. Wang, Takanori Hasegawa, Ryunosuke Saiki, Takayoshi Hyugaji, Eigo Shimizu, Kotoe Katayama, Masahiro Kanai, Tatsuhiko Naito, Noah Sasa, Kenichi Yamamoto, Kazuhisa Takahashi, Norihiro Harada, Toshio Naito, Makoto Hiki, Yasushi Matsushita, Haruhi Takagi, Masako Ichikawa, Ai Nakamura, Sonoko Harada, Yuuki Sandhu, Hiroki Kabata, Katsunori Masaki, Hirofumi Kamata, Shinnosuke Ikemura, Shotaro Chubachi, Satoshi Okamori, Hideki Terai, Atsuho Morita, Takanori Asakura, Junichi Sasaki, Hiroshi Morisaki, Yoshifumi Uwamino, Kosaku Nanki, Sho Uchida, Shunsuke Uno, Tomoyasu Nishimura, Takashi Ishiguro, Taisuke Isono, Shun Shibata, Yuma Matsui, Chiaki Hosoda, Kenji Takano, Takashi Nishida, Yoichi Kobayashi, Yotaro Takaku, Noboru Takayanagi, Soichiro Ueda, Ai Tada, Masayoshi Miyawaki, Masaomi Yamamoto, Eriko Yoshida, Reina Hayashi, Tomoki Nagasaka, Sawako Arai, Yutaro Kaneko, Kana Sasaki, Etsuko Tagaya, Masatoshi Kawana, Ken Arimura, Kunihiko Takahashi, Tatsuhiko Anzai, Satoshi Ito, Akifumi Endo, Yuji Uchimura, Yasunari Miyazaki, Takayuki Honda, Tomoya Tateishi, Shuji Tohda, Naoya Ichimura, Kazunari Sonobe, Chihiro Tani Sassa, Jun Nakajima, Yasushi Nakano, Yukiko Nakajima, Ryusuke Anan, Ryosuke Arai, Yuko Kurihara, Yuko Harada, Kazumi Nishio, Tetsuya Ueda, Masanori Azuma, Ryuichi Saito, Toshikatsu Sado, Yoshimune Miyazaki, Ryuichi Sato, Yuki Haruta, Tadao Nagasaki, Yoshinori Yasui, Yoshinori Hasegawa, Yoshikazu Mutoh, Tomoki Kimura, Tomonori Sato, Reoto Takei, Satoshi Hagimoto, Yoichiro Noguchi, Yasuhiko Yamano, Hajime Sasano, Sho Ota, Yasushi Nakamori, Kazuhisa Yoshiya, Fukuki Saito, Tomoyuki Yoshihara, Daiki Wada, Hiromu Iwamura, Syuji Kanayama, Shuhei Maruyama, Takashi Yoshiyama, Ken Ohta, Hiroyuki Kokuto, Hideo Ogata, Yoshiaki Tanaka, Kenichi Arakawa, Masafumi Shimoda, Takeshi Osawa, Hiroki Tateno, Isano Hase, Shuichi Yoshida, Shoji Suzuki, Miki Kawada, Hirohisa Horinouchi, Fumitake Saito, Keiko Mitamura, Masao Hagihara, Junichi Ochi, Tomoyuki Uchida, Rie Baba, Daisuke Arai, Takayuki Ogura, Hidenori Takahashi, Shigehiro Hagiwara, Genta Nagao, Shunichiro Konishi, Ichiro Nakachi, Koji Murakami, Mitsuhiro Yamada, Hisatoshi Sugiura, Hirohito Sano, Shuichiro Matsumoto, Nozomu Kimura, Yoshinao Ono, Hiroaki Baba, Yusuke Suzuki, Sohei Nakayama, Keita Masuzawa, Shinichi Namba, Takayuki Shiroyama, Yoshimi Noda, Takayuki Niitsu, Yuichi Adachi, Takatoshi Enomoto, Saori Amiya, Reina Hara, Tomoki Kuge, Kinnosuke Matsumoto, Yuji Yamamoto, Makoto Yamamoto, Midori Yoneda, Kazunori Tomono, Kazuto Kato, Hidefumi Koh, Tadashi Manabe, Yohei Funatsu, Fumimaro Ito, Takahiro Fukui, Keisuke Shinozuka, Sumiko Kohashi, Masatoshi Miyazaki, Tomohisa Shoko, Mitsuaki Kojima, Tomohiro Adachi, Motonao Ishikawa, Kenichiro Takahashi, Takashi Inoue, Toshiyuki Hirano, Keigo Kobayashi, Hatsuyo Takaoka, Kazuyoshi Watanabe, Naoki Miyazawa, Yasuhiro Kimura, Reiko Sado, Hideyasu Sugimoto, Akane Kamiya, Naota Kuwahara, Akiko Fujiwara, Tomohiro Matsunaga, Yoko Sato, Takenori Okada, Yoshihiro Hirai, Hidetoshi Kawashima, Atsuya Narita, Kazuki Niwa, Yoshiyuki Sekikawa, Koichi Nishi, Masaru Nishitsuji, Mayuko Tani, Junya Suzuki, Hiroki Nakatsumi, Takashi Ogura, Hideya Kitamura, Eri Hagiwara, Kota Murohashi, Hiroko Okabayashi, Takao Mochimaru, Shigenari Nukaga, Ryosuke Satomi, Yoshitaka Oyamada, Nobuaki Mori, Tomoya Baba, Yasutaka Fukui, Mitsuru Odate, Shuko Mashimo, Yasushi Makino, Kazuma Yagi, Mizuha Hashiguchi, Junko Kagyo, Tetsuya Shiomi, Satoshi Fuke, Hiroshi Saito, Tomoya Tsuchida, Shigeki Fujitani, Mumon Takita, Daiki Morikawa, Toru Yoshida, Takehiro Izumo, Minoru Inomata, Naoyuki Kuse, Nobuyasu Awano, Mari Tone, Akihiro Ito, Yoshihiko Nakamura, Kota Hoshino, Junichi Maruyama, Hiroyasu Ishikura, Tohru Takata, Toshio Odani, Masaru Amishima, Takeshi Hattori, Yasuo Shichinohe, Takashi Kagaya, Toshiyuki Kita, Kazuhide Ohta, Satoru Sakagami, Kiyoshi Koshida, Kentaro Hayashi, Tetsuo Shimizu, Yutaka Kozu, Hisato Hiranuma, Yasuhiro Gon, Namiki Izumi, Kaoru Nagata, Ken Ueda, Reiko Taki, Satoko Hanada, Kodai Kawamura, Kazuya Ichikado, Kenta Nishiyama, Hiroyuki Muranaka, Kazunori Nakamura, Naozumi Hashimoto, Keiko Wakahara, Sakamoto Koji, Norihito Omote, Akira Ando, Nobuhiro Kodama, Yasunari Kaneyama, Shunsuke Maeda, Takashige Kuraki, Takemasa Matsumoto, Koutaro Yokote, Taka-Aki Nakada, Ryuzo Abe, Taku Oshima, Tadanaga Shimada, Masahiro Harada, Takeshi Takahashi, Hiroshi Ono, Toshihiro Sakurai, Takayuki Shibusawa, Yoshifumi Kimizuka, Akihiko Kawana, Tomoya Sano, Chie Watanabe, Ryohei Suematsu, Hisako Sageshima, Ayumi Yoshifuji, Kazuto Ito, Saeko Takahashi, Kota Ishioka, Morio Nakamura, Makoto Masuda, Aya Wakabayashi, Hiroki Watanabe, Suguru Ueda, Masanori Nishikawa, Yusuke Chihara, Mayumi Takeuchi, Keisuke Onoi, Jun Shinozuka, Atsushi Sueyoshi, Yoji Nagasaki, Masaki Okamoto, Sayoko Ishihara, Masatoshi Shimo, Yoshihisa Tokunaga, Yu Kusaka, Takehiko Ohba, Susumu Isogai, Aki Ogawa, Takuya Inoue, Satoru Fukuyama, Yoshihiro Eriguchi, Akiko Yonekawa, Keiko Kan-o, Koichiro Matsumoto, Kensuke Kanaoka, Shoichi Ihara, Kiyoshi Komuta, Yoshiaki Inoue, Shigeru Chiba, Kunihiro Yamagata, Yuji Hiramatsu, Hirayasu Kai, Koichiro Asano, Tsuyoshi Oguma, Yoko Ito, Satoru Hashimoto, Masaki Yamasaki, Yu Kasamatsu, Yuko Komase, Naoya Hida, Takahiro Tsuburai, Baku Oyama, Minoru Takada, Hidenori Kanda, Yuichiro Kitagawa, Tetsuya Fukuta, Takahito Miyake, Shozo Yoshida, Shinji Ogura, Shinji Abe, Yuta Kono, Yuki Togashi, Hiroyuki Takoi, Ryota Kikuchi, Shinichi Ogawa, Tomouki Ogata, Shoichiro Ishihara, Arihiko Kanehiro, Shinji Ozaki, Yasuko Fuchimoto, Sae Wada, Nobukazu Fujimoto, Kei Nishiyama, Mariko Terashima, Satoru Beppu, Kosuke Yoshida, Osamu Narumoto, Hideaki Nagai, Nobuharu Ooshima, Mitsuru Motegi, Akira Umeda, Kazuya Miyagawa, Hisato Shimada, Mayu Endo, Yoshiyuki Ohira, Masafumi Watanabe, Sumito Inoue, Akira Igarashi, Masamichi Sato, Hironori Sagara, Akihiko Tanaka, Shin Ohta, Tomoyuki Kimura, Yoko Shibata, Yoshinori Tanino, Takefumi Nikaido, Hiroyuki Minemura, Yuki Sato, Yuichiro Yamada, Takuya Hashino, Masato Shinoki, Hajime Iwagoe, Hiroshi Takahashi, Kazuhiko Fujii, Hiroto Kishi, Masayuki Kanai, Tomonori Imamura, Tatsuya Yamashita, Masakiyo Yatomi, Toshitaka Maeno, Shinichi Hayashi, Mai Takahashi, Mizuki Kuramochi, Isamu Kamimaki, Yoshiteru Tominaga, Tomoo Ishii, Mitsuyoshi Utsugi, Akihiro Ono, Toru Tanaka, Takeru Kashiwada, Kazue Fujita, Yoshinobu Saito, Masahiro Seike, Hiroko Watanabe, Hiroto Matsuse, Norio Kodaka, Chihiro Nakano, Takeshi Oshio, Takatomo Hirouchi, Shohei Makino, Moritoki Egi, Yosuke Omae, Yasuhito Nannya, Takafumi Ueno, Tomomi Takano, Kazuhiko Katayama, Masumi Ai, Toshiro Sato, Naoki Hasegawa, Katsushi Tokunaga, Makoto Ishii, Ryuji Koike, Yuko Kitagawa, Akinori Kimura, Seiya Imoto, Satoru Miyano, Seishi Ogawa, Takanori Kanai, Ho Namkoong, Hiromu Tanaka, Ho Lee, Koichi Fukunaga, Haruhiko Hirata, Yoshito Takeda, Daisuke Okuzaki, Atsushi Kumanogoh, Yukinori Okada

Nature Genetics　Vol. 55　No. 5　p. 753-767　2023年4月24日　研究論文（学術雑誌）

Immunomics analysis of rheumatoid arthritis identified precursor dendritic cells as a key cell subset of treatment resistance

Saeko Yamada, Yasuo Nagafuchi, Min Wang, Mineto Ota, Hiroaki Hatano, Yusuke Takeshima, Mai Okubo, Satomi Kobayashi, Yusuke Sugimori, Nakano Masahiro, Ryochi Yoshida, Norio Hanata, Yuichi Suwa, Yumi Tsuchida, Yukiko Iwasaki, Shuji Sumitomo, Kanae Kubo, Kenichi Shimane, Keigo Setoguchi, Takanori Azuma, Hiroko Kanda, Hirofumi Shoda, Xuan Zhang, Kazuhiko Yamamoto, Kazuyoshi Ishigaki, Tomohisa Okamura, Keishi Fujio

Annals of the Rheumatic Diseases　Vol. 82　No. 6　p. 809-819　2023年3月14日　研究論文（学術雑誌）

Transcriptome Profiling of Immune Cell Types in Peripheral Blood Reveals Common and Specific Pathways Involved in the Pathogenesis of Myositis‐Specific Antibody‐Positive Inflammatory Myopathies

Yusuke Sugimori, Yukiko Iwasaki, Yusuke Takeshima, Mai Okubo, Satomi Kobayashi, Hiroaki Hatano, Saeko Yamada, Masahiro Nakano, Ryochi Yoshida, Mineto Ota, Yumi Tsuchida, Yasuo Nagafuchi, Kenichi Shimane, Ken Yoshida, Daitaro Kurosaka, Shuji Sumitomo, Hirofumi Shoda, Kazuhiko Yamamoto, Tomohisa Okamura, Keishi Fujio

ACR Open Rheumatology　Vol. 5　No. 2　p. 93-102　2023年1月18日　研究論文（学術雑誌）

Consecutive BNT162b2 mRNA vaccination induces short-term epigenetic memory in innate immune cells

Yuta Yamaguchi, Yasuhiro Kato, Ryuya Edahiro, Jonas N. Søndergaard, Teruaki Murakami, Saori Amiya, Shinichiro Nameki, Yuko Yoshimine, Takayoshi Morita, Yusuke Takeshima, Shuhei Sakakibara, Yoko Naito, Daisuke Motooka, Yu-Chen Liu, Yuya Shirai, Yasutaka Okita, Jun Fujimoto, Haruhiko Hirata, Yoshito Takeda, James B. Wing, Daisuke Okuzaki, Yukinori Okada, Atsushi Kumanogoh

JCI Insight　Vol. 7　No. 22　2022年10月25日　研究論文（学術雑誌）

Distinct transcriptome architectures underlying lupus establishment and exacerbation

Masahiro Nakano, Mineto Ota, Yusuke Takeshima, Yukiko Iwasaki, Hiroaki Hatano, Yasuo Nagafuchi, Takahiro Itamiya, Junko Maeda, Ryochi Yoshida, Saeko Yamada, Aya Nishiwaki, Haruka Takahashi, Hideyuki Takahashi, Yuko Akutsu, Takeshi Kusuda, Hiroyuki Suetsugu, Lu Liu, Kwangwoo Kim, Xianyong Yin, So-Young Bang, Yong Cui, Hye-Soon Lee, Hirofumi Shoda, Xuejun Zhang, Sang-Cheol Bae, Chikashi Terao, Kazuhiko Yamamoto, Tomohisa Okamura, Kazuyoshi Ishigaki, Keishi Fujio

Cell　2022年8月15日　研究論文（学術雑誌）

Transcriptome analysis of immune cells from Behçet’s syndrome patients: the importance of IL-17-producing cells and antigen-presenting cells in the pathogenesis of Behçet’s syndrome

Mai Okubo, Shuji Sumitomo, Yumi Tsuchida, Yasuo Nagafuchi, Yusuke Takeshima, Haruyuki Yanaoka, Harumi Shirai, Satomi Kobayashi, Yusuke Sugimori, Junko Maeda, Hiroaki Hatano, Yukiko Iwasaki, Hirofumi Shoda, Tomohisa Okamura, Kazuhiko Yamamoto, Mineto Ota, Keishi Fujio

Arthritis Research & Therapy　Vol. 24　No. 1　p. 186-186　2022年8月8日　研究論文（学術雑誌）

Myasthenia gravis-specific aberrant neuromuscular gene expression by medullary thymic epithelial cells in thymoma

Yoshiaki Yasumizu, Naganari Ohkura, Hisashi Murata, Makoto Kinoshita, Soichiro Funaki, Satoshi Nojima, Kansuke Kido, Masaharu Kohara, Daisuke Motooka, Daisuke Okuzaki, Shuji Suganami, Eriko Takeuchi, Yamami Nakamura, Yusuke Takeshima, Masaya Arai, Satoru Tada, Meinoshin Okumura, Eiichi Morii, Yasushi Shintani, Shimon Sakaguchi, Tatsusada Okuno, Hideki Mochizuki

Nature Communications　Vol. 13　No. 1　2022年7月22日　研究論文（学術雑誌）

Dysregulation of the gene signature of effector regulatory T cells in the early phase of systemic sclerosis

Satomi Kobayashi, Yasuo Nagafuchi, Mai Okubo, Yusuke Sugimori, Hiroaki Hatano, Saeko Yamada, Masahiro Nakano, Ryochi Yoshida, Yusuke Takeshima, Mineto Ota, Yumi Tsuchida, Yukiko Iwasaki, Keigo Setoguchi, Kanae Kubo, Tomohisa Okamura, Kazuhiko Yamamoto, Hirofumi Shoda, Keishi Fujio

Rheumatology　Vol. 61　No. 10　p. 4163-4174　2022年1月18日　研究論文（学術雑誌）

Dynamic landscape of immune cell-specific gene regulation in immune-mediated diseases

Mineto Ota, Yasuo Nagafuchi, Hiroaki Hatano, Kazuyoshi Ishigaki, Chikashi Terao, Yusuke Takeshima, Haruyuki Yanaoka, Satomi Kobayashi, Mai Okubo, Harumi Shirai, Yusuke Sugimori, Junko Maeda, Masahiro Nakano, Saeko Yamada, Ryochi Yoshida, Haruka Tsuchiya, Yumi Tsuchida, Shuji Akizuki, Hajime Yoshifuji, Koichiro Ohmura, Tsuneyo Mimori, Ken Yoshida, Daitaro Kurosaka, Masato Okada, Keigo Setoguchi, Hiroshi Kaneko, Nobuhiro Ban, Nami Yabuki, Kosuke Matsuki, Hironori Mutoh, Sohei Oyama, Makoto Okazaki, Hiroyuki Tsunoda, Yukiko Iwasaki, Shuji Sumitomo, Hirofumi Shoda, Yuta Kochi, Yukinori Okada, Kazuhiko Yamamoto, Tomohisa Okamura, Keishi Fujio

Cell　Vol. 184　No. 11　p. 3006-3021.e17　2021年5月　研究論文（学術雑誌）

Identifying the most influential gene expression profile in distinguishing ANCA-associated vasculitis from healthy controls

Haruyuki Yanaoka, Yasuo Nagafuchi, Norio Hanata, Yusuke Takeshima, Mineto Ota, Yuichi Suwa, Harumi Shirai, Yusuke Sugimori, Mai Okubo, Satomi Kobayashi, Hiroaki Hatano, Saeko Yamada, Yumi Tsuchida, Yukiko Iwasaki, Shuji Sumitomo, Hirofumi Shoda, Masato Okada, Tomohisa Okamura, Kazuhiko Yamamoto, Keishi Fujio

Journal of Autoimmunity　Vol. 119　p. 102617-102617　2021年5月　研究論文（学術雑誌）

Integrated bulk and single-cell RNA-sequencing identified disease-relevant monocytes and a gene network module underlying systemic sclerosis

Satomi Kobayashi, Yasuo Nagafuchi, Mai Okubo, Yusuke Sugimori, Harumi Shirai, Hiroaki Hatano, Maeda Junko, Haruyuki Yanaoka, Yusuke Takeshima, Mineto Ota, Yukiko Iwasaki, Shuji Sumitomo, Tomohisa Okamura, Kazuhiko Yamamoto, Hirofumi Shoda, Keishi Fujio

Journal of Autoimmunity　Vol. 116　p. 102547-102547　2020年10月　研究論文（学術雑誌）

シェーグレン症候群とIgG4関連疾患 原発性シェーグレン症候群の末梢血免疫細胞に対する包括的遺伝子発現解析(Sjoegren and IgG4-related syndrome Comprehensive gene expression analysis of peripheral blood immune cells of primary Sjogren's syndrome)

Okubo Mai, Sumitomo Shuji, Ota Mineto, Takeshima Yusuke, Yanaoka Haruyuki, Shirai Harumi, Kobayashi Satomi, Sugimori Yusuke, Maeda Junko, Hatano Hiroaki, Nagafuchi Yasuo, Iwasaki Yukiko, Shoda Hirofumi, Okamura Tomohisa, Yamamoto Kazuhiko, Fujio Keishi

日本リウマチ学会総会・学術集会プログラム・抄録集　Vol. 64回　p. 317-317　2020年8月

Myositis PBMCの免疫細胞サブセットのRNA-Seqにより明らかとなった特発性炎症性ミオパチーの病因における単球系特異的遺伝子シグネチャーの重要性(RNA-Seq of immune cell subsets in PBMC identified the importance of specific monocyte gene signatures for idiopathic inflammatory myopathy pathogenesis)

Sugimori Yusuke, Iwasaki Yukiko, Takeshima Yusuke, Yoshida Ryochi, Hatano Hiroaki, Maeda Junko, Okubo Mai, Kobayashi Satomi, Ota Mineto, Nagafuchi Yasuo, Sumitomo Shuji, Shoda Hirofumi, Yoshida Ken, Okamura Tomohisa, Kurosaka Daitaro, Fujio Keishi

日本リウマチ学会総会・学術集会プログラム・抄録集　Vol. 64回　p. 321-321　2020年8月

全身性エリテマトーデス 基礎 免疫細胞の包括的なトランスクリプトーム解析により全身性エリテマトーデス患者の層別化の経路が明らかとなり、その病因となるメカニズムについての洞察が得られた(Systemic lupus erythematosus: Basic Comprehensive transcriptome approach of immune cells reveals pathways for systemic lupus erythematosus patient stratification with insights into the mechanisms underlying its pathogenesis)

Nakano Masahiro, Iwasaki Yukiko, Takeshima Yusuke, Ota Mineto, Nagafuchi Yasuo, Sumitomo Shuji, Okamura Tomohisa, Fujio Keishi

日本リウマチ学会総会・学術集会プログラム・抄録集　Vol. 64回　p. 326-326　2020年8月

RAの予後予測 関節リウマチの免疫細胞プロファイリングにて同定された治療抵抗性の重要な相関因子としてプラスマブラスト経路(Outcome prediction in RA Immune cell profiling of rheumatoid arthritis identified plasmablast pathways as key correlates with treatment resistance)

Yamada Saeko, Nagafuchi Yasuo, Ota Mineto, Takeshima Yusuke, Hatano Hiroaki, Iwasaki Yukiko, Sumitomo Shuji, Okamura Tomohisa, Shoda Hirofumi, Yamamoto Kazuhiko, Fujio Keishi

日本リウマチ学会総会・学術集会プログラム・抄録集　Vol. 64回　p. 352-352　2020年8月

トランスクリプトームとスプライシングデータを用いた自己免疫疾患の鑑別(Distinguishing autoimmune diseases using transcriptome and splicing data)

Hatano Hiroaki, Ota Mineto, Nagafuchi Yasuo, Takeshima Yusuke, Kobayashi Satomi, Okubo Mai, Sugimori Yusuke, Shirai Harumi, Yanaoka Haruyuki, Maeda Junko, Yamada Saeko, Nakano Masahiro, Yoshida Ryochi, Iwasaki Yukiko, Sumitomo Shuji, Okamura Tomohisa, Shoda Hirofumi, Yamamoto Kazuhiko, Fujio Keishi

日本リウマチ学会総会・学術集会プログラム・抄録集　Vol. 64回　p. 541-541　2020年8月

Basic mechanism of immune system activation by mitochondria.

Yukiko Iwasaki, Yusuke Takeshima, Keishi Fujio

Immunological medicine　Vol. 43　No. 4　p. 1-6　2020年5月12日　研究論文（学術雑誌）

Review: transcriptome and trans-omics analysis of systemic lupus erythematosus.

Keishi Fujio, Yusuke Takeshima, Masahiro Nakano, Yukiko Iwasaki

Inflammation and regeneration　Vol. 40　p. 11-11　2020年　研究論文（学術雑誌）

ヒト免疫学 関節リウマチの免疫細胞構成の分析から明らかになった治療抵抗性に相関する遺伝子ネットワークとBCRレパートリーの多様性(Human Immunology Immune cell profiling of rheumatoid arthritis identified gene networks and BCR repertoire diversity correlated with treatment resistance)

Yamada Saeko, Nagafuchi Yasuo, Ota Mineto, Takeshima Yusuke, Hatano Hiroaki, Iwasaki Yukiko, Sumitomo Shuji, Okamura Tomohisa, Shoda Hirofumi, Yamamoto Kazuhiko, Fujio Keishi

日本免疫学会総会・学術集会記録　Vol. 48　No. Proceedings　p. 1-O/P　2019年11月

全身性エリテマトーデスとその他の自己免疫疾患 全身性エリテマトーデスの免疫細胞の組成分析は病状形成の重要な調節因子の発見をもたらし患者の層別化に役立つ(Systemic lupus erythematosus and other systemic autoimmune diseases Immune cell profiling of systemic lupus erythematosus reveals a key regulator of its pathogenesis and contributes to patient stratification)

Nakano Masahiro, Iwasaki Yukiko, Takeshima Yusuke, Ota Mineto, Nagafuchi Yasuo, Sumitomo Shuji, Okamura Tomohisa, Fujio Keishi

日本免疫学会総会・学術集会記録　Vol. 48　No. Proceedings　p. 2-O/P　2019年11月

全身性エリテマトーデスとその他の自己免疫疾患 免疫細胞サブセットのトランスクリプトーム解析から明らかになった特発性炎症性筋疾患の病態への細胞種特異的な寄与(Systemic lupus erythematosus and other systemic autoimmune diseases Transcriptome analysis of immune cell subsets reveals cell type-specific contributions to the pathophysiology of idiopathic inflammatory myopathy)

Sugimori Yusuke, Iwasaki Yukiko, Takeshima Yusuke, Hatano Hiroaki, Okubo Mai, Kobayashi Satomi, Ota Mineto, Nagafuchi Yasuo, Sumitomo Shuji, Shoda Hirofumi, Okamura Tomohisa, Fujio Keishi

日本免疫学会総会・学術集会記録　Vol. 48　No. Proceedings　p. 2-P　2019年11月

関節リウマチ、シェーグレン症候群、その他の自己免疫疾患 ベーチェット病に関与する免疫細胞サブセットの免疫表現型と遺伝子発現分析による解析(Rheumatoid arthritis, Sjogren's syndrome and other autoimmune diseases Investigation of immune cell subsets involved in Behcet's syndrome by immunophenotyping and gene expression analysis)

Okubo Mai, Sumitomo Shuji, Ota Mineto, Takeshima Yusuke, Kobayashi Satomi, Sugimori Yusuke, Nagafuchi Yasuo, Iwasaki Yukiko, Shoda Hirofumi, Okamura Tomohisa, Yamamoto Kazuhiko, Fujio Keishi

日本免疫学会総会・学術集会記録　Vol. 48　No. Proceedings　p. 3-O/P　2019年11月

Delayed lupus nephritis in the course of systemic lupus erythematosus is associated with a poorer treatment response: a multicentre, retrospective cohort study in Japan.

M Nakano, K Kubo, Y Shirota, Y Iwasaki, Y Takahashi, T Igari, Y Inaba, Y Takeshima, S Tateishi, H Yamashita, M Miyazaki, H Sato, H Kanda, H Kaneko, T Ishii, K Fujio, N Tanaka, A Mimori

Lupus　Vol. 28　No. 9　p. 1062-1073　2019年8月　研究論文（学術雑誌）

Metabolism as a key regulator in the pathogenesis of systemic lupus erythematosus.

Yusuke Takeshima, Yukiko Iwasaki, Keishi Fujio, Kazuhiko Yamamoto

Seminars in arthritis and rheumatism　Vol. 48　No. 6　p. 1142-1145　2019年6月　研究論文（学術雑誌）

遺伝学 関節リウマチの免疫細胞の組成分析から明らかになった疾患活性と治療抵抗性に関連する遺伝子ネットワーク(Genetics Immune cell profiling of rheumatoid arthritis identified disease activity and treatment resistance related gene networks)

Yamada Saeko, Nagafuchi Yasuo, Ota Mineto, Takeshima Yusuke, Hatano Hiroaki, Iwasaki Yukiko, Sumitomo Shuji, Okamura Tomohisa, Shoda Hirofumi, Yamamoto Kazuhiko, Fujio Keishi

日本リウマチ学会総会・学術集会プログラム・抄録集　Vol. 63回　p. 326-326　2019年3月

免疫調節細胞 Tr1細胞のIL-10産生におけるJazf1の役割(Immunoregulatory Cells The role of Jazf1 in the production of IL-10 in Tr1 cells)

Kono Masanori, Okamura Tomohisa, Inoue Mariko, Komai Toshihiko, Iwasaki Yukiko, Takeshima Yusuke, Sumitomo Shuji, Shoda Hirofumi, Yamamoto Kazuhiko, Fujio Keishi

日本リウマチ学会総会・学術集会プログラム・抄録集　Vol. 63回　p. 392-392　2019年3月

全身性硬化症と線維症 バルク細胞検体と単一細胞の統合的なRNAシークエンス分析により同定された全身性硬化症に関連する単球サブセットと重要な炎症推進遺伝子モジュール(Systemic Sclerosis and Fibrosis Integrated bulk and single-cell RNA-sequencing identified disease relevant monocyte subset and key driver inflammatory gene module of systemic sclerosis)

Kobayashi Satomi, Nagafuchi Yasuo, Shoda Hirofumi, Okubo Mai, Sugimori Yusuke, Ota Mineto, Takeshima Yusuke, Iwasaki Yukiko, Sumitomo Shuji, Okamura Tomohisa, Yamamoto Kazuhiko, Fujio Keishi

日本リウマチ学会総会・学術集会プログラム・抄録集　Vol. 63回　p. 404-404　2019年3月

自己免疫 リンパ球サブセット特異的トランスクリプトーム解析は全身性エリテマトーデス(SLE)のB細胞異常におけるミトコンドリアの関与を明らかにした(Autoimmunity Lymphocyte subset-specific transcriptome analyses revealed the involvement of mitochondria in B cells abnormality of systemic lupus erythematosus(SLE))

Yamamoto Kazuhiko, Takeshima Yusuke, Iwasaki Yukiko, Ota Mineto, Ishigaki Kazuyoshi, Sumitomo Shuji, Suzuki Akari, Kochi Yuta, Okamura Tomohisa, Fujio Keishi

日本免疫学会総会・学術集会記録　Vol. 47　No. Proceedings　p. S6-5　2018年12月

全身性自己免疫疾患 免疫細胞型特異的multi-omics解析により明らかにされた全身性エリテマトーデスに対するB細胞におけるミトコンドリアの関与(Systemic autoimmune diseases-1 Immune cell-type specific multi-omics analysis revealed contribution of mitochondria in Bcells to systemic lupus erythematosus)

Takeshima Yusuke, Iwasaki Yukiko, Ota Mineto, Nagafuchi Yasuo, Sumitomo Shuji, Kochi Yuta, Okamura Tomohisa, Yamamoto Kazuhiko, Fujio Keishi

日本免疫学会総会・学術集会記録　Vol. 47　No. Proceedings　p. 1-O/P　2018年12月

全身性自己免疫疾患 RNA-Seq transcriptomicsは特発性炎症性ミオパシーの病因に関する各免疫細胞サブセットの潜在的関与を明らかにする(Systemic autoimmune diseases-1 RNA-Seq transcriptomics reveals potential contribution of each immune cell subset to the pathogenesis of idiopathic inflammatory myopathy)

Sugimori Yusuke, Iwasaki Yukiko, Takeshima Yusuke, Ota Mineto, Nagafuchi Yasuo, Sumitomo Shuji, Shoda Hirofumi, Kochi Yuta, Okamura Tomohisa, Yamamoto Kazuhiko, Fujio Keishi

日本免疫学会総会・学術集会記録　Vol. 47　No. Proceedings　p. 1-O/P　2018年12月

全身性自己免疫疾患 ベーチェット病におけるPBMCサブセットの免疫表現型分類と遺伝子発現解析(Systemic autoimmune diseases-1 Immunophenotyping and gene expression analysis of PBMC subsets in Behcet's disease)

Okubo Mai, Sumitomo Shuji, Ota Mineto, Takeshima Yusuke, Kobayashi Satomi, Sugimori Yusuke, Nagafuchi Yasuo, Iwasaki Yukiko, Shoda Hirofumi, Okamura Tomohisa, Yamamoto Kazuhiko, Fujio Keishi

日本免疫学会総会・学術集会記録　Vol. 47　No. Proceedings　p. 1-O/P　2018年12月

全身性自己免疫疾患 全身性硬化症の特徴的遺伝子モジュールを探求するための末梢血免疫細胞のトランスクリプトーム解析(Systemic autoimmune diseases-1 Transcriptome analysis of peripheral blood immune cells for exploring characteristic gene module of systemic sclerosis)

Kobayashi Satomi, Nagafuchi Yasuo, Shoda Hirofumi, Okubo Mai, Sugimori Yusuke, Ohta Mineto, Takeshima Yusuke, Iwasaki Yukiko, Sumitomo Shuji, Okamura Tomohisa, Yamamoto Kazuhiko, Fujio Keishi

日本免疫学会総会・学術集会記録　Vol. 47　No. Proceedings　p. 1-O/P　2018年12月

全身性自己免疫疾患 免疫細胞表現型分類によるANCA関連血管炎における疾患特異的白血球サブセットの同定(Systemic autoimmune diseases-1 Identifying disease-specific leukocyte subsets in ANCA-associated vasculitis through immune cell phenotyping)

Yanaoka Haruyuki, Nagafuchi Yasuo, Takeshima Yusuke, Ota Mineto, Shirai Harumi, Iwasaki Yukiko, Shoda Hirofumi, Sumitomo Shuji, Okamura Tomohisa, Kochi Yuta, Yamamoto Kazuhiko, Fujio Keishi

日本免疫学会総会・学術集会記録　Vol. 47　No. Proceedings　p. 1-P　2018年12月

Polymorphic lymphoproliferative disorders in patients with rheumatoid arthritis are associated with a better clinical outcome.

Daisuke Tsukui, Hiroko Kanda, Aya Shinozaki-Ushiku, Shoko Tateishi, Yusuke Takeshima, Yasuo Nagafuchi, Oh Sasaki, Yukiko Iwasaki, Hiroaki Harada, Mihoko Shibuya, Shuji Sumitomo, Hirofumi Shoda, Kanae Kubo, Keishi Fujio, Fumihiko Nakamura, Mineo Kurokawa, Masashi Fukayama, Kazuhiko Yamamoto

Modern rheumatology　Vol. 28　No. 4　p. 621-625　2018年7月　研究論文（学術雑誌）

SLEの病因1 全身性エリテマトーデスの病因を明らかにするための免疫細胞サブセットのマルチオミクス解析(SLE pathogenesis(1) Multi-omics analysis of immune cell subsets for revealing the pathogenesis of systemic lupus erythematosus)

Takeshima Yusuke, Iwasaki Yukiko, Ota Mineto, Ishigaki Kazuyoshi, Sumitomo Shuji, Kochi Yuta, Okamura Tomohisa, Koyasu Shigeo, Yamamoto Kazuhiko, Fujio Keishi

日本リウマチ学会総会・学術集会プログラム・抄録集　Vol. 62回　p. 375-375　2018年3月

SLEの病因2 さまざまなB細胞サブセットのRNAシーケンスによって明らかになったSLEにおける異常なB細胞受容体レパートリーの成熟(SLE pathogenesis(2) Abnormal B cell receptor repertoire maturation in SLE unveiled by RNA sequencing of various B cell subsets)

Ota Mineto, Ishigaki Kazuyoshi, Sumitomo Shuji, Takeshima Yusuke, Iwasaki Yukiko, Okamura Tomohisa, Kochi Yuta, Yamamoto Kazuhiko, Fujio Keishi

日本リウマチ学会総会・学術集会プログラム・抄録集　Vol. 62回　p. 376-376　2018年3月

JSIサマースクールと連携した若手免疫学者対象のワークショップ 全身性エリテマトーデス(SLE)由来の末梢血単核細胞(PBMC)を用いたゲノムおよびトランスクリプトームの統合分析(Workshop for young immunologists collaborated with the JSI summer school Integrative analysis of genome and transcriptome using peripheral blood mononuclear cells(PBMCs) from systemic lupus erythematosus(SLE))

Takeshima Yusuke, Iwasaki Yukiko, Ota Mineto, Nagafuchi Yasuo, Sumitomo Shuji, Kochi Yuta, Okamura Tomohisa, Fujio Keishi, Yamamoto Kazuhiko

日本免疫学会総会・学術集会記録　Vol. 46　No. Proceedings　p. 1-O　2017年12月

B細胞の発生と機能 免疫細胞のRNAシーケンシングによって明らかになったSLEにおける異常B細胞受容体レパートリーの成熟(B cell development and function Abnormal B cell receptor repertoire maturation in SLE unveiled by RNA sequencing of immune cells)

Ota Mineto, Ishigaki Kazuyoshi, Sumitomo Shuji, Takeshima Yusuke, Iwasaki Yukiko, Kochi Yuta, Yamamoto Kazuhiko, Fujio Keishi

日本免疫学会総会・学術集会記録　Vol. 46　No. Proceedings　p. 3-O/P　2017年12月

全身性自己免疫疾患(2) 末梢血単核細胞(PBMC)における免疫細胞サブセットの総合的ゲノム解析およびトランスクリプトーム解析により全身性エリテマトーデスに対するB細胞ミトコンドリアの寄与が明らかになった(Systemic autoimmune disease(2) Comprehensive analysis of genome and transcriptome analysis of immune cell subsets in peripheral blood mononuclear cells(PBMCs) revealed mitochondria contribution in B cells to systemic lupus erythematosus)

Takeshima Yusuke, Iwasaki Yukiko, Ota Mineto, Nagafuchi Yasuo, Ishigaki Kazuyoshi, Sumitomo Shuji, Kochi Yuta, Okamura Tomohisa, Fujio Keishi, Yamamoto Kazuhiko

日本免疫学会総会・学術集会記録　Vol. 46　No. Proceedings　p. 3-O/P　2017年12月

全身性自己免疫疾患(2) 血漿メタボロミクス分析とトランスクリプトームデータの併用によりSLE患者の層別化ができる(Systemic autoimmune disease(2) Plasma metabolomic analysis combined with transcriptome data has potential for stratification of SLE patients)

Iwasaki Yukiko, Takeshima Yusuke, Ota Mineto, Nagafuchi Yasuo, Sumitomo Shuji, Kochi Yuta, Okamura Tomohisa, Koyasu Shigeo, Fujio Keishi, Yamamoto Kazuhiko

日本免疫学会総会・学術集会記録　Vol. 46　No. Proceedings　p. 3-O/P　2017年12月

SLE-2 末梢血単核球(PBMCs)の細胞型特異的なRNA-seqから明らかになった全身性エリテマトーデスへのB細胞の寄与(SLE Cell type-specific RNA-seq of peripheral blood mononuclear cells (PBMCs) revealed mitochondria contribution in B cells to systemic lupus erythematosus)

Takeshima Yusuke, Iwasaki Yukiko, Ota Mineto, Ishigaki Kazuyoshi, Sumitomo Shuji, Shoda Hirofumi, Kochi Yuta, Okamura Tomohisa, Fujio Keishi, Yamamoto Kazuhiko

日本リウマチ学会総会・学術集会プログラム・抄録集　Vol. 61回　p. 350-350　2017年3月

RA-2 RAにおける免疫細胞サブセットのトランスクリプトームによる特徴の分析(RA Transcriptome profiling of immune cell subsets in rheumatoid arthritis)

Ota Mineto, Sumitomo Shuji, Ishigaki Kazuyoshi, Takeshima Yusuke, Iwasaki Yukiko, Kochi Yuta, Fujio Keishi, Yamamoto Kazuhiko

日本リウマチ学会総会・学術集会プログラム・抄録集　Vol. 61回　p. 358-358　2017年3月

全身性エリテマトーデスの病態と代謝制御~新規治療応用の可能性~

竹島雄介, 岩崎由希子, 岡村僚久, 藤尾圭志, 山本一彦

日本臨床免疫学会会誌　Vol. 40　No. 1　p. 12-20　2017年

全身性自己免疫疾患-2 末梢血単核球(PBMC)の細胞タイプ特異的トランスクリプトーム解析によりB細胞の全身性ループスエリテマトーデス病因への寄与が明らかになる(Systemic autoimmune diseases(2) Cell-type-specific transcriptome analysis of peripheral blood mononuclear cells(PBMCs) revealed B cell contribution to systemic lupus erythematosus pathogenesis)

Takeshima Yusuke, Iwasaki Yukiko, Ota Mineto, Ishigaki Kazuyoshi, Sumitomo Shuji, Kochi Yuta, Okamura Tomohisa, Fujio Keishi, Yamamoto Kazuhiko

日本免疫学会総会・学術集会記録　Vol. 45　No. Proceedings　p. 75-75　2016年11月

炎症性関節症 関節リウマチにおける生物製剤投与前後の様々な免疫細胞サブセットのRNAシークエンシング(Inflammatory Arthropathy RNA sequencing of various immune cell subsets before and after biologics in rheumatoid arthritis)

Ota Mineto, Sumitomo Shuji, Takeshima Yusuke, Iwasaki Yukiko, Ishigaki Kazuyoshi, Kochi Yuta, Fujio Keishi, Yamamoto Kazuhiko

日本免疫学会総会・学術集会記録　Vol. 45　No. Proceedings　p. 103-103　2016年11月

Successful treatment of acute kidney injury in patients with idiopathic nephrotic syndrome using human atrial natriuretic Peptide.

Kohei Ueda, Junichi Hirahashi, George Seki, Mototsugu Tanaka, Natsuki Kushida, Yusuke Takeshima, Yoshitaka Nishikawa, Toshiro Fujita, Masaomi Nangaku

Internal medicine (Tokyo, Japan)　Vol. 53　No. 8　p. 865-9　2014年　研究論文（学術雑誌）