EN

基本情報

研究

社会活動

その他の活動

保仙 直毅

Hosen Naoki

医学系研究科 医学専攻,教授

keyword がん幹細胞,多発性骨髄腫,抗体療法,CAR T細胞療法

学歴

  • 1998年04月 ~ 2002年03月,大阪大学大学院,医学系研究科
  • 1988年04月 ~ 1994年03月,大阪大学,医学部

経歴

  • 2021年11月 ~ 継続中,大阪大学免疫フロンティア研究センター,免疫細胞治療学,教授
  • 2020年01月 ~ 継続中,大阪大学大学院医学系研究科,血液・腫瘍内科学,教授
  • 2014年04月 ~ 2019年12月,大阪大学大学院医学系研究科,癌幹細胞制御学寄附講座,准教授
  • 2009年04月 ~ 2014年03月,大阪大学大学院医学系研究科,生体情報科学,准教授
  • 2007年05月 ~ 2009年03月,大阪大学大学院医学系研究科,癌幹細胞制御学寄附講座,准教授
  • 2003年12月 ~ 2007年03月,スタンフォード大学医学部,病理学,ポスドク’(学振海外特別研究員)
  • 2003年06月 ~ 2003年11月,大阪大学医学部附属病院,血液・腫瘍内科,医員
  • 2002年12月 ~ 2003年05月,NTT西日本大阪病院,血液内科,医員
  • 2002年04月 ~ 2002年12月,大阪大学医学部,血液内科(分子病態内科学),研究生
  • 1997年06月 ~ 1998年05月,大阪府立成人病センター,血液内科,レジデント
  • 1995年06月 ~ 1997年05月,大阪逓信病院,内科,医員
  • 1994年05月 ~ 1995年05月,大阪大学医学部附属病院,研修医

研究内容・専門分野

  • ライフサイエンス,血液、腫瘍内科学

論文

  • High numbers of programmed cell death-1-positive tumor infiltrating lymphocytes correlate with early onset of post-transplant lymphoproliferative disorder.,Hideaki Saito,Hiroaki Miyoshi,Hirohiko Shibayama,Jun Toda,Shinsuke Kusakabe,Michiko Ichii,Jiro Fujita,Kentaro Fukushima,Tetsuo Maeda,Masao Mizuki,Kenji Oritani,Masao Seto,Takafumi Yokota,Yuzuru Kanakura,Naoki Hosen,Koichi Ohshima,International journal of hematology,Vol. 114,No. 1,p. 53-64,2021年07月,研究論文(学術雑誌)
  • Expression of activated integrin β7 in multiple myeloma patients.,Naoki Hosen,Satoshi Yoshihara,Hiroyuki Takamatsu,Masaki Ri,Yasuyuki Nagata,Hiroshi Kosugi,Yoshimitsu Shimomura,Ichiro Hanamura,Shigeo Fuji,Koichiro Minauchi,Junya Kuroda,Rikio Suzuki,Noriko Nishimura,Nobuhiko Uoshima,Hirohisa Nakamae,Yawara Kawano,Ishikazu Mizuno,Hiroshi Gomyo,Kenshi Suzuki,Shuji Ozaki,Shingen Nakamura,Yoichi Imai,Masahiro Kizaki,Eiju Negoro,Hiroshi Handa,Shinsuke Iida,International journal of hematology,Vol. 114,No. 1,p. 3-7,2021年07月,研究論文(学術雑誌)
  • Autonomous TGFβ signaling induces phenotypic variation in human acute myeloid leukemia.,Yasuhiro Shingai,Takafumi Yokota,Daisuke Okuzaki,Takao Sudo,Tomohiko Ishibashi,Yukiko Doi,Tomoaki Ueda,Takayuki Ozawa,Ritsuko Nakai,Akira Tanimura,Michiko Ichii,Hirohiko Shibayama,Yuzuru Kanakura,Naoki Hosen,Stem cells (Dayton, Ohio),Vol. 39,No. 6,p. 723-736,2021年06月,研究論文(学術雑誌)
  • Graft-versus-host disease develops in mice transplanted with lymphocyte-depleted bone marrow cells from signal-transducing adaptor protein-2 transgenic mice.,Hideaki Saito,Michiko Ichii,Jun Toda,Yuichi Kitai,Ryuta Muromoto,Jun-Ichi Kashiwakura,Kodai Saitoh,Akira Tanimura,Takafumi Yokota,Hirohiko Shibayama,Tadashi Matsuda,Kenji Oritani,Yuzuru Kanakura,Naoki Hosen,Biochemical and biophysical research communications,Vol. 537,p. 118-124,2021年01月22日,研究論文(学術雑誌)
  • Current Understanding of Myelomatous Mesenchymal Stromal Cells Extended through Advances in Experimental Methods.,Michiko Ichii,Naoki Hosen,Cancers,Vol. 13,No. 1,2020年12月23日,研究論文(学術雑誌)
  • Signal-transducing adapter protein-1 is required for maintenance of leukemic stem cells in CML.,Jun Toda,Michiko Ichii,Kenji Oritani,Hirohiko Shibayama,Akira Tanimura,Hideaki Saito,Takafumi Yokota,Daisuke Motooka,Daisuke Okuzaki,Yuichi Kitai,Ryuta Muromoto,Jun-Ichi Kashiwakura,Tadashi Matsuda,Naoki Hosen,Yuzuru Kanakura,Oncogene,Vol. 39,No. 34,p. 5601-5615,2020年08月,研究論文(学術雑誌)
  • Identification of two distinct populations of WT1-specific cytotoxic T lymphocytes in co-vaccination of WT1 killer and helper peptides.,Fumihiro Fujiki,Akihiro Tsuboi,Soyoko Morimoto,Naoya Hashimoto,Miki Inatome,Hiroko Nakajima,Jun Nakata,Sumiyuki Nishida,Kana Hasegawa,Naoki Hosen,Yoshihiro Oka,Yusuke Oji,Shinji Sogo,Haruo Sugiyama,Cancer immunology, immunotherapy : CII,2020年07月22日,研究論文(学術雑誌)
  • Integrins in multiple myeloma.,Naoki Hosen,Inflammation and regeneration,Vol. 40,p. 4-4,2020年,研究論文(学術雑誌)
  • Chimeric Antigen Receptor T-Cell Therapy for Multiple Myeloma.,Naoki Hosen,Cancers,Vol. 11,No. 12,2019年12月15日
  • Immune adjuvant therapy using Bacillus Calmette-Guérin cell wall skeleton (BCG-CWS) in advanced malignancies: A phase 1 study of safety and immunogenicity assessments.,Nishida S,Tsuboi A,Tanemura A,Ito T,Nakajima H,Shirakata T,Morimoto S,Fujiki F,Hosen N,Oji Y,Kumanogoh A,Kawase I,Oka Y,Azuma I,Morita S,Sugiyama H,Medicine,Vol. 98,No. 33,2019年08月,研究論文(学術雑誌)
  • The activated conformation of integrin β<sub>7</sub> is a novel multiple myeloma-specific target for CAR T cell therapy.,Hosen N,Matsunaga Y,Hasegawa K,Matsuno H,Nakamura Y,Makita M,Watanabe K,Yoshida M,Satoh K,Morimoto S,Fujiki F,Nakajima H,Nakata J,Nishida S,Tsuboi A,Oka Y,Manabe M,Ichihara H,Aoyama Y,Mugitani A,Nakao T,Hino M,Uchibori R,Ozawa K,Baba Y,Terakura S,Wada N,Morii E,Nishimura J,Takeda K,Oji Y,Sugiyama H,Takagi J,Kumanogoh A,Nature medicine,Vol. 23,No. 12,p. 1436-+,2017年12月,研究論文(学術雑誌)
  • Wilms' Tumor Gene 1 (WT1) Peptide Vaccine Therapy for Hematological Malignancies: From CTL Epitope Identification to Recent Progress in Clinical Studies Including a Cure-Oriented Strategy.,Yoshihiro Oka,Akihiro Tsuboi,Jun Nakata,Sumiyuki Nishida,Naoki Hosen,Atsushi Kumanogoh,Yusuke Oji,Haruo Sugiyama,Oncology research and treatment,Vol. 40,No. 11,p. 682-690,2017年,研究論文(学術雑誌)
  • A Zbtb7a proto-oncogene as a novel target for miR-125a,Nozomi Hojo,Naoya Tatsumi,Nahoko Moriguchi,Akihide Matsumura,Soyoko Morimoto,Jun Nakata,Fumihiro Fujiki,Sumiyuki Nishida,Hiroko Nakajima,Akihiro Tsuboi,Yoshihiro Oka,Naoki Hosen,Seiji Hayashi,Haruo Sugiyama,Yusuke Oji,MOLECULAR CARCINOGENESIS,WILEY-BLACKWELL,Vol. 55,No. 12,p. 2001-2009,2016年12月,研究論文(学術雑誌)
  • Syndecan-4 as a biomarker to predict clinical outcome for glioblastoma multiforme treated with WT1 peptide vaccine.,Satoshi Takashima,Yoshihiro Oka,Fumihiro Fujiki,Soyoko Morimoto,Hiroko Nakajima,Yoshiki Nakae,Jun Nakata,Sumiyuki Nishida,Naoki Hosen,Naoya Tatsumi,Kenji Mizuguchi,Naoya Hashimoto,Yusuke Oji,Akihiro Tsuboi,Atsushi Kumanogoh,Haruo Sugiyama,Future science OA,Vol. 2,No. 4,2016年12月,研究論文(学術雑誌)
  • Association of WT1 IgG antibody against WT1 peptide with prolonged survival in glioblastoma multiforme patients vaccinated with WT1 peptide,Yusuke Oji,Naoya Hashimoto,Akihiro Tsuboi,Yui Murakami,Miki Iwai,Naoki Kagawa,Yasuyoshi Chiba,Shuichi Izumoto,Olga Elisseeva,Ryo Ichinohasama,Junichi Sakamoto,Satoshi Morita,Hiroko Nakajima,Satoshi Takashima,Yoshiki Nakae,Jun Nakata,Manabu Kawakami,Sumiyuki Nishida,Naoki Hosen,Fumihiro Fujiki,Soyoko Morimoto,Mayuko Adachi,Masahiro Iwamoto,Yoshihiro Oka,Toshiki Yoshimine,Haruo Sugiyama,INTERNATIONAL JOURNAL OF CANCER,WILEY-BLACKWELL,Vol. 139,No. 6,p. 1391-1401,2016年09月,研究論文(学術雑誌)
  • An Essential Role of the Avidity of T-Cell Receptor in Differentiation of Self-Antigen-reactive CD8(+) T Cells,Kenta Kondo,Fumihiro Fujiki,Hiroko Nakajima,Erika Yatsukawa,Soyoko Morimoto,Naoya Tatsumi,Sumiyuki Nishida,Jun Nakata,Yoshihiro Oka,Akihiro Tsuboi,Naoki Hosen,Yusuke Oji,Haruo Sugiyama,JOURNAL OF IMMUNOTHERAPY,LIPPINCOTT WILLIAMS & WILKINS,Vol. 39,No. 3,p. 127-139,2016年04月,研究論文(学術雑誌)
  • Glycosylation Status of CD43 Protein Is Associated with Resistance of Leukemia Cells to CTL-Mediated Cytolysis,Kana Hasegawa,Satomi Tanaka,Fumihiro Fujiki,Soyoko Morimoto,Katsuhiko Nakano,Hiroko Kinoshita,Atsushi Okumura,Yuka Fujioka,Rika Urakawa,Hiroko Nakajima,Naoya Tatsumi,Jun Nakata,Satoshi Takashima,Sumiyuki Nishida,Akihiro Tsuboi,Yoshihiro Oka,Yusuke Oji,Eiji Miyoshi,Takako Hirata,Atsushi Kumanogoh,Haruo Sugiyama,Naoki Hosen,PLOS ONE,PUBLIC LIBRARY SCIENCE,Vol. 11,No. 3,2016年03月,研究論文(学術雑誌)
  • Deficiency in WT1-targeting microRNA-125a leads to myeloid malignancies and urogenital abnormalities,N. Tatsumi,N. Hojo,O. Yamada,M. Ogawa,Y. Katsura,S. Kawata,E. Morii,H. Sakamoto,R. Inaba,A. Tsuda,I. Fukuda,N. Moriguchi,H. Hasuwa,M. Okabe,F. Fujiki,S. Nishida,H. Nakajima,A. Tsuboi,Y. Oka,N. Hosen,H. Sugiyama,Y. Oji,ONCOGENE,NATURE PUBLISHING GROUP,Vol. 35,No. 8,p. 1003-1014,2016年02月,研究論文(学術雑誌)
  • Wilms tumor 1 peptide vaccination after hematopoietic stem cell transplant in leukemia patients.,Naoki Hosen,Tetsuo Maeda,Yoshiko Hashii,Akihiro Tsuboi,Sumiyuki Nishida,Jun Nakata,Yusuke Oji,Yoshihiro Oka,Haruo Sugiyama,Stem cell investigation,Vol. 3,p. 90-90,2016年,研究論文(学術雑誌)
  • Wilms' tumor gene WT1 promotes homologous recombination-mediated DNA damage repair,Yusuke Oji,Naoya Tatsumi,Junya Kobayashi,Mari Fukuda,Tazu Ueda,Eri Nakano,Chisae Saito,Syohei Shibata,Mihoko Sumikawa,Hisashi Fukushima,Akari Saito,Nozomi Hojo,Miyu Suzuki,Tomoko Hoshikawa,Tsutomu Shimura,Eiichi Morii,Yoshihiro Oka,Naoki Hosen,Kenshi Komatsu,Haruo Sugiyama,MOLECULAR CARCINOGENESIS,WILEY-BLACKWELL,Vol. 54,No. 12,p. 1758-1771,2015年12月,研究論文(学術雑誌)
  • An Immunocompetent Mouse Model for MLL/AF9 Leukemia Reveals the Potential of Spontaneous Cytotoxic T-Cell Response to an Antigen Expressed in Leukemia Cells,Kana Hasegawa,Satomi Tanaka,Fumihiro Fujiki,Soyoko Morimoto,Hiroko Nakajima,Naoya Tatsumi,Jun Nakata,Satoshi Takashima,Sumiyuki Nishida,Akihiro Tsuboi,Yoshihiro Oka,Yusuke Oji,Atsushi Kumanogoh,Haruo Sugiyama,Naoki Hosen,PLOS ONE,PUBLIC LIBRARY SCIENCE,Vol. 10,No. 12,2015年12月,研究論文(学術雑誌)
  • Two distinct effector memory cell populations of WT1 (Wilms' tumor gene 1)-specific cytotoxic T lymphocytes in acute myeloid leukemia patients,Yoshiki Nakae,Yoshihiro Oka,Fumihiro Fujiki,Soyoko Morimoto,Toshio Kamiya,Satoshi Takashima,Jun Nakata,Sumiyuki Nishida,Hiroko Nakajima,Naoki Hosen,Akihiro Tsuboi,Taiichi Kyo,Yusuke Oji,Kenji Mizuguchi,Atsushi Kumanogoh,Haruo Sugiyama,CANCER IMMUNOLOGY IMMUNOTHERAPY,SPRINGER,Vol. 64,No. 7,p. 791-804,2015年07月,研究論文(学術雑誌)
  • Wilms tumor 1 peptide vaccination combined with temozolomide against newly diagnosed glioblastoma: safety and impact on immunological response,Naoya Hashimoto,Akihiro Tsuboi,Naoki Kagawa,Yasuyoshi Chiba,Shuichi Izumoto,Manabu Kinoshita,Noriyuki Kijima,Yoshihiro Oka,Soyoko Morimoto,Hiroko Nakajima,Satoshi Morita,Junichi Sakamoto,Sumiyuki Nishida,Naoki Hosen,Yusuke Oji,Norio Arita,Toshiki Yoshimine,Haruo Sugiyama,CANCER IMMUNOLOGY IMMUNOTHERAPY,SPRINGER,Vol. 64,No. 6,p. 707-716,2015年06月,研究論文(学術雑誌)
  • Identification of a Novel C-Terminal Truncated WT1 Isoform with Antagonistic Effects against Major WT1 Isoforms,Naoya Tatsumi,Nozomi Hojo,Hiroyuki Sakamoto,Rena Inaba,Nahoko Moriguchi,Keiko Matsuno,Mari Fukuda,Akihide Matsumura,Seiji Hayashi,Soyoko Morimoto,Jun Nakata,Fumihiro Fujiki,Sumiyuki Nishida,Hiroko Nakajima,Akihiro Tsuboi,Yoshihiro Oka,Naoki Hosen,Haruo Sugiyama,Yusuke Oji,PLOS ONE,PUBLIC LIBRARY SCIENCE,Vol. 10,No. 6,2015年06月,研究論文(学術雑誌)
  • Interleukin-6/interleukin-21 signaling axis is critical in the pathogenesis of pulmonary arterial hypertension,Takahiro Hashimoto-Kataoka,Naoki Hosen,Takashi Sonobe,Yoh Arita,Taku Yasui,Takeshi Masaki,Masato Minami,Tadakatsu Inagaki,Shigeru Miyagawa,Yoshiki Sawa,Masaaki Murakami,Atsushi Kumanogoh,Keiko Yamauchi-Takihara,Meinoshin Okumura,Tadamitsu Kishimoto,Issei Komuro,Mikiyasu Shirai,Yasushi Sakata,Yoshikazu Nakaoka,PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,NATL ACAD SCIENCES,Vol. 112,No. 20,p. E2677-E2686,2015年05月,研究論文(学術雑誌)
  • [Identification and targeting of multiple myeloma stem cells].,Hosen N,Nihon rinsho. Japanese journal of clinical medicine,Vol. 73,No. 5,p. 816-822,2015年05月
  • Transduction of a Novel HLA-DRB1*04:05-restricted, WT1-specific TCR Gene into Human CD4(+) T Cells Confers Killing Activity Against Human Leukemia Cells,Akiko Katsuhara,Fumihiro Fujiki,Nao Aoyama,Satoe Tanii,Soyoko Morimoto,Yoshihiro Oka,Akihiro Tsuboi,Hiroko Nakajima,Kenta Kondo,Naoya Tatsumi,Jun Nakata,Yoshiki Nakae,Satoshi Takashima,Sumiyuki Nishida,Naoki Hosen,Shinji Sogo,Yusuke Oji,Haruo Sugiyama,ANTICANCER RESEARCH,INT INST ANTICANCER RESEARCH,Vol. 35,No. 3,p. 1251-1261,2015年03月,研究論文(学術雑誌)
  • Expansion of range of joint motion following treatment of systemic sclerosis with tocilizumab,Yoshihito Shima,Naoki Hosen,Toru Hirano,Junsuke Arimitsu,Sumiyuki Nishida,Keisuke Hagihara,Masashi Narazaki,Atsushi Ogata,Toshio Tanaka,Tadamitsu Kishimoto,Atsushi Kumanogoh,MODERN RHEUMATOLOGY,SPRINGER,Vol. 25,No. 1,p. 134-137,2015年01月,研究論文(学術雑誌)
  • [Multiple myeloma stem cell].,Hosen N,Nihon rinsho. Japanese journal of clinical medicine,Vol. 73,No. 1,p. 47-51,2015年01月
  • The Wilms' tumour suppressor Wt1 is a major regulator of tumour angiogenesis and progression,Kay-Dietrich Wagner,Julien Cherfils-Vicini,Naoki Hosen,Peter Hohenstein,Eric Gilson,Nicholas D. Hastie,Jean-Francois Michiels,Nicole Wagner,NATURE COMMUNICATIONS,NATURE PUBLISHING GROUP,Vol. 5,2014年12月,研究論文(学術雑誌)
  • Vaccination strategies to improve outcome of hematopoietic stem cell transplant in leukemia patients: early evidence and future prospects,Naoki Hosen,Tetsuo Maeda,Yoshiko Hashii,Akihiro Tsuboi,Sumiyuki Nishida,Jun Nakata,Yoshiki Nakae,Satoshi Takashima,Yusuke Oji,Yoshihiro Oka,Atsushi Kumanogoh,Haruo Sugiyama,EXPERT REVIEW OF HEMATOLOGY,EXPERT REVIEWS,Vol. 7,No. 5,p. 671-681,2014年10月
  • In vivo eradication of MLL/ENL leukemia cells by NK cells in the absence of adaptive immunity,J. Nakata,K. Nakano,A. Okumura,Y. Mizutani,H. Kinoshita,M. Iwai,K. Hasegawa,S. Morimoto,F. Fujiki,N. Tatsumi,H. Nakajima,Y. Nakae,S. Nishida,A. Tsuboi,Y. Oji,Y. Oka,H. Sugiyama,A. Kumanogoh,N. Hosen,LEUKEMIA,NATURE PUBLISHING GROUP,Vol. 28,No. 6,p. 1316-1325,2014年06月,研究論文(学術雑誌)
  • The translation elongation factor eEF2 is a novel tumor‑associated antigen overexpressed in various types of cancers.,Oji Y,Tatsumi N,Fukuda M,Nakatsuka S,Aoyagi S,Hirata E,Nanchi I,Fujiki F,Nakajima H,Yamamoto Y,Shibata S,Nakamura M,Hasegawa K,Takagi S,Fukuda I,Hoshikawa T,Murakami Y,Mori M,Inoue M,Naka T,Tomonaga T,Shimizu Y,Nakagawa M,Hasegawa J,Nezu R,Inohara H,Izumoto S,Nonomura N,Yoshimine T,Okumura M,Morii E,Maeda H,Nishida S,Hosen N,Tsuboi A,Oka Y,Sugiyama H,International journal of oncology,Vol. 44,No. 5,p. 1461-1469,2014年05月,研究論文(学術雑誌)
  • Wilms Tumor Gene ( WT1) Peptide- based Cancer Vaccine Combined With Gemcitabine for Patients With Advanced Pancreatic Cancer,Sumiyuki Nishida,Shigeo Koido,Yutaka Takeda,Sadamu Homma,Hideo Komita,Akitaka Takahara,Satoshi Morita,Toshinori Ito,Soyoko Morimoto,Kazuma Hara,Akihiro Tsuboi,Yoshihiro Oka,Satoru Yanagisawa,Yoichi Toyama,Masahiro Ikegami,Toru Kitagawa,Hidetoshi Eguchi,Hiroshi Wada,Hiroaki Nagano,Jun Nakata,Yoshiki Nakae,Naoki Hosen,Yusuke Oji,Toshio Tanaka,Ichiro Kawase,Atsushi Kumanogoh,Junichi Sakamoto,Yuichiro Doki,Masaki Mori,Toshifumi Ohkusa,Hisao Tajiri,Haruo Sugiyama,JOURNAL OF IMMUNOTHERAPY,LIPPINCOTT WILLIAMS & WILKINS,Vol. 37,No. 2,p. 105-114,2014年02月,研究論文(学術雑誌)
  • Wilms' Tumor 1 Is Involved in Tumorigenicity of Glioblastoma by Regulating Cell Proliferation and Apoptosis,Noriyuki Kijima,Naoki Hosen,Naoki Kagawa,Naoya Hashimoto,Manabu Kinoshita,Yusuke Oji,Haruo Sugiyama,Toshiki Yoshimine,ANTICANCER RESEARCH,INT INST ANTICANCER RESEARCH,Vol. 34,No. 1A,p. 61-67,2014年01月,研究論文(学術雑誌)
  • Maintenance of complete remission after allogeneic stem cell transplantation in leukemia patients treated with Wilms tumor 1 peptide vaccine,T. Maeda,N. Hosen,K. Fukushima,A. Tsuboi,S. Morimoto,T. Matsui,H. Sata,J. Fujita,K. Hasegawa,S. Nishida,J. Nakata,Y. Nakae,S. Takashima,H. Nakajima,F. Fujiki,N. Tatsumi,T. Kondo,M. Hino,Y. Oji,Y. Oka,Y. Kanakura,A. Kumanogoh,H. Sugiyama,Blood Cancer Journal,Vol. 3,No. 8,2013年08月,研究論文(学術雑誌)
  • Functional human Th17 clones with WT1-specific helper activity,Sho Tachino,Fumihiro Fujiki,Yoshihiro Oka,Akihiro Tsuboi,Soyoko Morimoto,Yu-Hung Lin,Taichi Tamanaka,Kenta Kondo,Hiroko Nakajima,Sumiyuki Nishida,Naoki Hosen,Yusuke Oji,Atsushi Kumanogoh,Haruo Sugiyama,CANCER IMMUNOLOGY IMMUNOTHERAPY,SPRINGER,Vol. 62,No. 4,p. 801-810,2013年04月,研究論文(学術雑誌)
  • HLA-DPB1*05:01-restricted WT1 (332)-specific TCR-transduced CD4(+) T Lymphocytes Display a Helper Activity for WT1-specific CTL Induction and a Cytotoxicity Against Leukemia Cells,Yuhung Lin,Fumihiro Fujiki,Akiko Katsuhara,Yoshihiro Oka,Akihiro Tsuboi,Nao Aoyama,Satoe Tanii,Hiroko Nakajima,Naoya Tatsumi,Soyoko Morimoto,Taichi Tamanaka,Sho Tachino,Naoki Hosen,Sumiyuki Nishida,Yusuke Oji,Atsushi Kumanogoh,Haruo Sugiyama,JOURNAL OF IMMUNOTHERAPY,LIPPINCOTT WILLIAMS & WILKINS,Vol. 36,No. 3,p. 159-170,2013年04月,研究論文(学術雑誌)
  • WT1 peptide immunotherapy for gynecologic malignancies resistant to conventional therapies: a phase II trial,Takashi Miyatake,Yutaka Ueda,Akiko Morimoto,Takayuki Enomoto,Sumiyuki Nishida,Toshiaki Shirakata,Yoshihiro Oka,Akihiro Tsuboi,Yusuke Oji,Naoki Hosen,Shin-ichi Nakatsuka,Satoshi Morita,Junichi Sakamoto,Haruo Sugiyama,Tadashi Kimura,JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY,SPRINGER,Vol. 139,No. 3,p. 457-463,2013年03月,研究論文(学術雑誌)
  • Multiple myeloma-initiating cells,Naoki Hosen,INTERNATIONAL JOURNAL OF HEMATOLOGY,SPRINGER JAPAN KK,Vol. 97,No. 3,p. 306-312,2013年03月,研究論文(学術雑誌)
  • Recognition of a Natural WT1 Epitope by a Modified WT1 Peptide-specific T-Cell Receptor,Taichi Tamanaka,Yoshihiro Oka,Fumihiro Fujiki,Akihiro Tsuboi,Akiko Katsuhara,Hiroko Nakajima,Naoki Hosen,Sumiyuki Nishida,Yu-Hung Lin,Sho Tachino,Yoshiki Akatsuka,Kiyotaka Kuzushima,Yusuke Oji,Atsushi Kumanogoh,Haruo Sugiyama,ANTICANCER RESEARCH,INT INST ANTICANCER RESEARCH,Vol. 32,No. 12,p. 5201-5209,2012年12月,研究論文(学術雑誌)
  • CD166/Activated leukocyte cell adhesion molecule is expressed on glioblastoma progenitor cells and involved in the regulation of tumor cell invasion,Noriyuki Kijima,Naoki Hosen,Naoki Kagawa,Naoya Hashimoto,Akiko Nakano,Yasunori Fujimoto,Manabu Kinoshita,Haruo Sugiyama,Toshiki Yoshimine,NEURO-ONCOLOGY,OXFORD UNIV PRESS INC,Vol. 14,No. 10,p. 1254-+,2012年10月,研究論文(学術雑誌)
  • CD138-negative clonogenic cells are plasma cells but not B cells in some multiple myeloma patients,N. Hosen,Y. Matsuoka,S. Kishida,J. Nakata,Y. Mizutani,K. Hasegawa,A. Mugitani,H. Ichihara,Y. Aoyama,S. Nishida,A. Tsuboi,F. Fujiki,N. Tatsumi,H. Nakajima,M. Hino,T. Kimura,K. Yata,M. Abe,Y. Oka,Y. Oji,A. Kumanogoh,H. Sugiyama,LEUKEMIA,NATURE PUBLISHING GROUP,Vol. 26,No. 9,p. 2135-2141,2012年09月,研究論文(学術雑誌)
  • Biased usage of T cell receptor β-chain variable region genes of Wilms' tumor gene (WT1)-specific CD8+ T cells in patients with solid tumors and healthy donors.,Soyoko Morimoto,Yoshihiro Oka,Akihiro Tsuboi,Yukie Tanaka,Fumihiro Fujiki,Hiroko Nakajima,Naoki Hosen,Sumiyuki Nishida,Jun Nakata,Yoshiki Nakae,Motohiko Maruno,Akira Myoui,Takayuki Enomoto,Shuichi Izumoto,Mitsugu Sekimoto,Naoki Kagawa,Naoya Hashimoto,Toshiki Yoshimine,Yusuke Oji,Atsushi Kumanogoh,Haruo Sugiyama,Cancer Sci.,Vol. 103,No. 3,p. 408-414,2012年03月,研究論文(学術雑誌)
  • Biased usage of T cell receptor β-chain variable region genes of Wilms' tumor gene (WT1)-specific CD8+ T cells in patients with solid tumors and healthy donors.,Morimoto S,Oka Y,Tsuboi A,Tanaka Y,Fujiki F,Nakajima H,Hosen N,Nishida S,Nakata J,Nakae Y,Maruno M,Myoui A,Enomoto T,Izumoto S,Sekimoto M,Kagawa N,Hashimoto N,Yoshimine T,Oji Y,Kumanogoh A,Sugiyama H,Cancer science,Vol. 103,No. 3,p. 408-414,2012年03月,研究論文(学術雑誌)
  • WT1 Peptide Therapy for a Patient with Chemotherapy-resistant Salivary Gland Cancer,Toshiaki Shirakata,Yoshihiro Oka,Sumiyuki Nishida,Naoki Hosen,Akihiro Tsuboi,Yusuke Oji,Ayako Murao,Hidetaka Tanaka,Shin-Ichi Nakatsuka,Hidenori Inohara,Haruo Sugiyama,ANTICANCER RESEARCH,INT INST ANTICANCER RESEARCH,Vol. 32,No. 3,p. 1081-1085,2012年03月,研究論文(学術雑誌)
  • CD48 as a novel molecular target for antibody therapy in multiple myeloma,Naoki Hosen,Hiroyoshi Ichihara,Atsuko Mugitani,Yasutaka Aoyama,Yuki Fukuda,Satoshi Kishida,Yoshikazu Matsuoka,Hiroko Nakajima,Manabu Kawakami,Tamotsu Yamagami,Shigeo Fuji,Hiroya Tamaki,Takafumi Nakao,Sumiyuki Nishida,Akihiro Tsuboi,Shinsuke Iida,Masayuki Hino,Yoshihiro Oka,Yusuke Oji,Haruo Sugiyama,BRITISH JOURNAL OF HAEMATOLOGY,WILEY-BLACKWELL,Vol. 156,No. 2,p. 213-224,2012年01月,研究論文(学術雑誌)
  • Enhanced tumor immunity of WT1 peptide vaccination by interferon-β administration.,Nakajima H,Oka Y,Tsuboi A,Tatsumi N,Yamamoto Y,Fujiki F,Li Z,Murao A,Morimoto S,Hosen N,Shirakata T,Nishida S,Kawase I,Isaka Y,Oji Y,Sugiyama H,Vaccine,Vol. 30,No. 4,p. 722-729,2012年01月,研究論文(学術雑誌)
  • WT1 peptide vaccine induces reduction in minimal residual disease in an Imatinib-treated CML patient,Yusuke Oji,Yoshihiro Oka,Sumiyuki Nishida,Akihiro Tsuboi,Manabu Kawakami,Toshiaki Shirakata,Kazuko Takahashi,Ayako Murao,Hiroko Nakajima,Miwako Narita,Masuhiro Takahashi,Satoshi Morita,Junichi Sakamoto,Toshio Tanaka,Ichiro Kawase,Naoki Hosen,Haruo Sugiyama,EUROPEAN JOURNAL OF HAEMATOLOGY,WILEY-BLACKWELL,Vol. 85,No. 4,p. 358-360,2010年10月,研究論文(学術雑誌)
  • A Clear Correlation between WT1-specific Th Response and Clinical Response in WT1 CTL Epitope Vaccination,Fumihiro Fujiki,Yoshihiro Oka,Mai Kawakatsu,Akihiro Tsuboi,Yukie Tanaka-Harada,Naoki Hosen,Sumiyuki Nishida,Toshiaki Shirakata,Hiroko Nakajima,Naoya Tatsumi,Naoya Hashimoto,Tetsuya Taguchi,Satsuki Ueda,Norio Nonomura,Yutaka Takeda,Toshinori Ito,Akira Myoui,Shuichi Izumoto,Motohiko Maruno,Toshiki Yoshimine,Shinzaburo Noguchi,Akihiko Okuyama,Ichiro Kawase,Yusuke Oji,Haruo Sugiyama,ANTICANCER RESEARCH,INT INST ANTICANCER RESEARCH,Vol. 30,No. 6,p. 2247-2254,2010年06月,研究論文(学術雑誌)
  • Effects of Concomitant Temozolomide and Radiation Therapies on WT1-specific T-cells in Malignant Glioma,Yasuyoshi Chiba,Naoya Hashimoto,Akihiro Tsuboi,Yoshihiro Oka,Ayako Murao,Manabu Kinoshita,Naoki Kagawa,Yusuke Oji,Naoki Hosen,Sumiyuki Nishida,Haruo Sugiyama,Toshiki Yoshimine,JAPANESE JOURNAL OF CLINICAL ONCOLOGY,OXFORD UNIV PRESS,Vol. 40,No. 5,p. 395-403,2010年05月,研究論文(学術雑誌)
  • High frequencies of less differentiated and more proliferative WT1-specific CD8+ T cells in bone marrow in tumor-bearing patients: An important role of bone marrow as a secondary lymphoid organ,Ayako Murao,Yoshihiro Oka,Akihiro Tsuboi,Olga A. Elisseeva,Yukie Tanaka-Harada,Fumihiro Fujiki,Hiroko Nakajima,Sumiyuki Nishida,Naoki Hosen,Toshiaki Shirakata,Nobuyuki Hashimoto,Akira Myoui,Takafumi Ueda,Yoshito Takeda,Tadashi Osaki,Takayuki Enomoto,Hideki Yoshikawa,Tadashi Kimura,Yusuke Oji,Ichiro Kawase,Haruo Sugiyama,Cancer Science,Vol. 101,No. 4,p. 848-854,2010年04月,研究論文(学術雑誌)
  • High frequencies of less differentiated and more proliferative WT1-specific CD8+ T cells in bone marrow in tumor-bearing patients: An important role of bone marrow as a secondary lymphoid organ,Ayako Murao,Yoshihiro Oka,Akihiro Tsuboi,Olga A. Elisseeva,Yukie Tanaka-Harada,Fumihiro Fujiki,Hiroko Nakajima,Sumiyuki Nishida,Naoki Hosen,Toshiaki Shirakata,Nobuyuki Hashimoto,Akira Myoui,Takafumi Ueda,Yoshito Takeda,Tadashi Osaki,Takayuki Enomoto,Hideki Yoshikawa,Tadashi Kimura,Yusuke Oji,Ichiro Kawase,Haruo Sugiyama,Cancer Science,Vol. 101,No. 4,p. 848-854,2010年04月,研究論文(学術雑誌)
  • Biased usage of BV gene families of T-cell receptors of WT1 (Wilms' tumor gene)-specific CD8+ T cells in patients with myeloid malignancies,Yukie Tanaka-Harada,Manabu Kawakami,Yoshihiro Oka,Akihiro Tsuboi,Takamasa Katagiri,Elisseeva Olga,Sumiyuki Nishida,Toshiaki Shirakata,Naoki Hosen,Fumihiro Fujiki,Ayako Murao,Hiroko Nakajima,Yusuke Oji,Yoshinobu Kanda,Ichiro Kawase,Haruo Sugiyama,Cancer Science,Vol. 101,No. 3,p. 594-600,2010年03月,研究論文(学術雑誌)
  • Biased usage of BV gene families of T-cell receptors of WT1 (Wilms&apos; tumor gene)-specific CD8(+) T cells in patients with myeloid malignancies,Yukie Tanaka-Harada,Manabu Kawakami,Yoshihiro Oka,Akihiro Tsuboi,Takamasa Katagiri,Olga A. Elisseeva,Sumiyuki Nishida,Toshiaki Shirakata,Naoki Hosen,Fumihiro Fujiki,Ayako Murao,Hiroko Nakajima,Yusuke Oji,Yoshinobu Kanda,Ichiro Kawase,Haruo Sugiyama,CANCER SCIENCE,WILEY-BLACKWELL,Vol. 101,No. 3,p. 594-600,2010年03月,研究論文(学術雑誌)
  • Wt1 is required for cardiovascular progenitor cell formation through transcriptional control of Snail and E-cadherin,Ofelia M. Martinez-Estrada,Laura A. Lettice,Abdelkader Essafi,Juan Antonio Guadix,Joan Slight,Victor Velecela,Emma Hall,Judith Reichmann,Paul S. Devenney,Peter Hohenstein,Naoki Hosen,Robert E. Hill,Ramon Munoz-Chapuli,Nicholas D. Hastie,NATURE GENETICS,NATURE PUBLISHING GROUP,Vol. 42,No. 1,p. 89-U112,2010年01月,研究論文(学術雑誌)
  • Self-Renewal of the Long-Term Reconstituting Subset of Hematopoietic Stem Cells is Regulated by Ikaros,Peter Papathanasiou,Joanne L. Attema,Holger Karsunky,Naoki Hosen,Yovina Sontani,Gerard F. Hoyne,Robert Tunningley,Stephen T. Smale,Irving L. Weissman,STEM CELLS,ALPHAMED PRESS,Vol. 27,No. 12,p. 3082-3092,2009年12月,研究論文(学術雑誌)
  • WT1 IgG antibody for early detection of nonsmall cell lung cancer and as its prognostic factor,Yusuke Oji,Yayoi Kitamura,Eriko Kamino,Aiko Kitano,Noriyoshi Sawabata,Masayoshi Inoue,Masahide Mori,Shin-ichi Nakatsuka,Nao Sakaguchi,Kaori Miyazaki,Michiyo Nakamura,Ikuyo Fukuda,Junya Nakamura,Naoya Tatsumi,Tetsuya Takakuwa,Sumiyuki Nishida,Toshiaki Shirakata,Naoki Hosen,Akihiro Tsuboi,Riichiro Nezu,Hajime Maeda,Yoshihiro Oka,Ichiro Kawase,Katsuyuki Aozasa,Meinoshin Okumura,Shinichiro Miyoshi,Haruo Sugiyama,INTERNATIONAL JOURNAL OF CANCER,WILEY-LISS,Vol. 125,No. 2,p. 381-387,2009年07月,研究論文(学術雑誌)
  • Expression of AA4.1 marks lymphohematopoietic progenitors in early mouse development,Toshiyuki Yamane,Naoki Hosen,Hidetoshi Yamazaki,Irving L. Weissman,PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,NATL ACAD SCIENCES,Vol. 106,No. 22,p. 8953-8958,2009年06月,研究論文(学術雑誌)
  • Overexpression of eukaryotic elongation factor eEF2 in gastrointestinal cancers and its involvement in G2/M progression in the cell cycle,Junya Nakamura,Sayaka Aoyagi,Isamu Nanchi,Shin-Ichi Nakatsuka,Erika Hirata,Shohei Shibata,Mari Fukuda,Yumiko Yamamoto,Ikuyo Fukuda,Naoya Tatsumi,Tazu Ueda,Fumihiro Fujiki,Masaya Nomura,Sumiyuki Nishida,Toshiaki Shirakata,Naoki Hosen,Akihoro Tsuboi,Yoshihiro Oka,Riichiro Nezu,Masaki Mori,Yuichiro Doki,Katsuyuki Aozasa,Haruo Sugiyama,Yusuke Oji,INTERNATIONAL JOURNAL OF ONCOLOGY,SPANDIDOS PUBL LTD,Vol. 34,No. 5,p. 1181-1189,2009年05月,研究論文(学術雑誌)
  • Identification of a WT1 protein-derived peptide, WT1(187), as a HLA-A*0206-restricted, WT1-specific CTL epitope,Zheyu Li,Yoshihiro Oka,Akihiro Tsuboi,Fumihiro Fujiki,Yukie Harada,Hiroko Nakajima,Tomoki Masuda,Yoko Fukuda,Mai Kawakatsu,Soyoko Morimoto,Takamasa Katagiri,Naoya Tatsumi,Naoki Hosen,Toshiaki Shirakata,Sumiyuki Nishida,Yutaka Kawakami,Keiko Udaka,Ichiro Kawase,Yusuke Oji,Haruo Sugiyama,MICROBIOLOGY AND IMMUNOLOGY,WILEY-BLACKWELL,Vol. 52,No. 11,p. 551-558,2008年11月,研究論文(学術雑誌)
  • Wilms tumor gene WT1 peptide-based immunotherapy induced a minimal response in a patient with advanced therapy-resistant multiple myeloma,Akihiro Tsuboi,Yoshihiro Oka,Hiroko Nakajima,Yoko Fukuda,Olga A. Elisseeva,Satoshi Yoshihara,Naoki Hosen,Atsushi Ogata,Katsuyuki Kito,Fumihiro Fujiki,Sumiyuki Nishida,Toshiaki Shirakata,Satoshi Ohno,Masaki Yasukawa,Yusuke Oji,Manabu Kawakami,Satoshi Morita,Junichi Sakamoto,Keiko Udaka,Ichiro Kawase,Haruo Sugiyama,INTERNATIONAL JOURNAL OF HEMATOLOGY,SPRINGER TOKYO,Vol. 86,No. 5,p. 414-417,2007年12月,研究論文(学術雑誌)
  • Transcriptional profiling of antigen-dependent murine B cell differentiation and memory formation,Deepta Bhattacharya,Ming T. Cheah,Christopher B. Franco,Naoki Hosen,Christopher L. Pin,William C. Sha,Irving L. Weissman,JOURNAL OF IMMUNOLOGY,AMER ASSOC IMMUNOLOGISTS,Vol. 179,No. 10,p. 6808-6819,2007年11月,研究論文(学術雑誌)
  • The Wilms' tumor gene WT1-GFP knock-in mouse reveals the dynamic regulation of WT1 expression in normal and leukemic hematopoiesis,N. Hosen,T. Shirakata,S. Nishida,M. Yanagihara,A. Tsuboi,M. Kawakami,Y. Oji,Y. Oka,M. Okabe,B. Tan,H. Sugiyama,I. L. Weissman,LEUKEMIA,NATURE PUBLISHING GROUP,Vol. 21,No. 8,p. 1783-1791,2007年08月,研究論文(学術雑誌)
  • Bmi-1-green fluorescent protein-knock-in mice reveal the dynamic regulation of Bmi-1 expression in normal and leukemic hematopoietic cells,Naoki Hosen,Toshiyuki Yamane,Manja Muijtjens,Kara Pham,Michael F. Clarke,Irving L. Weissman,STEM CELLS,ALPHAMED PRESS,Vol. 25,No. 7,p. 1635-1644,2007年07月,研究論文(学術雑誌)
  • CD96 is a leukemic stem cell-specific marker in human acute myeloid leukemia,Naoki Hosen,Christopher Y. Park,Naoya Tatsumi,Yusuke Oji,Haruo Sugiyama,Martin Gramatzki,Alan M. Krensky,Irving L. Weissman,PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,NATL ACAD SCIENCES,Vol. 104,No. 26,p. 11008-11013,2007年06月,研究論文(学術雑誌)
  • AML1-ETO rapidly induces acute myeloblastic leukemia in cooperation with the Wilms tumor gene, WT1.,S Nishida,N Hosen,T Shirakata,K Kanato,M Yanagihara,S Nakatsuka,Y Hoshida,T Nakazawa,Y Harada,N Tatsumi,A Tsuboi,M Kawakami,Y Oka,Y Oji,K Aozasa,Kawase, I,H Sugiyama,BLOOD,AMER SOC HEMATOLOGY,Vol. 107,No. 8,p. 3303-3312,2006年04月,研究論文(学術雑誌)
  • Wilms' tumor gene WT1 17AA(-)/KTS(-) isoform induces morphological changes and promotes cell migration and invasion in vitro,T Jomgeow,Y Oji,N Tsuji,Y Ikeda,K Ito,A Tsuda,T Nakazawa,N Tatsumi,N Sakaguchi,S Takashima,T Shirakata,S Nishida,N Hosen,M Kawakami,A Tsuboi,Y Oka,K Itoh,H Sugiyama,CANCER SCIENCE,BLACKWELL PUBLISHING,Vol. 97,No. 4,p. 259-270,2006年04月,研究論文(学術雑誌)
  • Th1-biased humoral immune responses against Wilms tumor gene WT1 product in the patients with hematopoietic malignancies,F Wu,Y Oka,A Tsuboi,OA Elisseeva,K Ogata,H Nakajima,F Fujiki,T Masuda,M Murakami,S Yoshihara,K Ikegame,N Hosen,M Kawakami,M Nakagawa,T Kubota,T Soma,T Yamagami,M Tsukaguchi,H Ogawa,Y Oji,T Hamaoka,Kawase, I,H Sugiyama,LEUKEMIA,NATURE PUBLISHING GROUP,Vol. 19,No. 2,p. 268-274,2005年02月,研究論文(学術雑誌)
  • The Wilms' tumor gene WT1 is a common marker of progenitor cells in fetal liver,K Kanato,N Hosen,M Yanagihara,N Nakagata,T Shirakata,T Nakazawa,S Nishida,A Tsuboi,M Kawakami,T Masuda,Y Oka,Y Oji,A IJpenberg,ND Hastie,H Sugiyama,BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,ACADEMIC PRESS INC ELSEVIER SCIENCE,Vol. 326,No. 4,p. 836-843,2005年01月,研究論文(学術雑誌)
  • Overexpression of the Wilms' tumor gene WT1 in primary astrocytic tumors,Y Oji,T Suzuki,Y Nakano,M Maruno,S Nakatsuka,T Jomgeow,S Abeno,N Tatsumi,A Yokota,S Aoyagi,T Nakazawa,K Ito,K Kanato,T Shirakata,S Nishida,N Hosen,M Kawakami,A Tsuboi,Y Oka,K Aozasa,T Yoshimine,H Sugiyama,CANCER SCIENCE,JAPANESE CANCER ASSOC,Vol. 95,No. 10,p. 822-827,2004年10月,研究論文(学術雑誌)
  • Induction of WT1 (Wilms' tumor gene)-specific cytotoxic T lymphocytes by WT1 peptide vaccine and the resultant cancer regression,Y Oka,A Tsuboi,T Taguchi,T Osaki,T Kyo,H Nakajima,OA Elisseeva,Y Oji,M Kawakami,K Ikegame,N Hosen,S Yoshihara,F Wu,F Fujiki,M Murakami,T Masuda,S Nishida,T Shirakata,S Nakatsuka,A Sasaki,K Udaka,H Dohy,K Aozasa,S Noguchi,L Kawase,H Sugiyama,PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,NATL ACAD SCIENCES,Vol. 101,No. 38,p. 13885-13890,2004年09月,研究論文(学術雑誌)
  • Overexpression of the Wilms' tumor gene WT1 in esophageal cancer,Y Oji,M Yano,Y Nakano,S Abeno,S Nakatsuka,A Ikeba,T Yasuda,Y Fujiwara,S Takiguchi,H Yamamoto,S Fujita,K Kanato,K Ito,T Jomgeow,M Kawakami,A Tsuboi,T Shirakata,S Nishida,N Hosen,Y Oka,K Aozasa,M Monden,H Sugiyama,ANTICANCER RESEARCH,INT INST ANTICANCER RESEARCH,Vol. 24,No. 5B,p. 3103-3108,2004年09月,研究論文(学術雑誌)
  • Powerful graft-versus-leukemia effects exerted by HLA-haploidentical grafts engrafted with a reduced-intensity regimen for relapse following myeloablative HLA-matched transplantation,H Ogawa,K Ikegame,M Kawakami,A Tsuboi,EH Kim,N Hosen,M Murakami,T Fujioka,T Masuda,Y Taniguchi,S Yoshihara,T Tatekawa,Y Oka,Kawase, I,T Soma,Y Oji,TRANSPLANTATION,LIPPINCOTT WILLIAMS & WILKINS,Vol. 78,No. 3,p. 488-489,2004年08月
  • Solitary right ventricle metastasis by renal cell carcinoma,M Masaki,T Kuroda,N Hosen,H Hirota,K Terai,Y Oshima,Y Nakaoka,S Sugiyama,R Kimura,S Yoshihara,M Kawakami,N Iizuka,Y Tomita,H Ogawa,Kawase, I,K Yamauchi-Takihara,JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY,MOSBY, INC,Vol. 17,No. 4,p. 397-398,2004年04月,研究論文(学術雑誌)
  • Identification of a gene element essential for leukemia-specific expression of transgenes,N Hosen,M Yanagihara,T Nakazawa,K Kanato,S Nishida,T Shirakata,M Asada,T Masuda,Y Taniguchi,M Kawakami,A Tsuboi,K Ikegame,Y Oka,H Ogawa,Kawase, I,Y Oji,H Sugiyama,LEUKEMIA,NATURE PUBLISHING GROUP,Vol. 18,No. 3,p. 415-419,2004年03月,研究論文(学術雑誌)
  • Absence of mutations in the Wilms' tumor gene WT1 in primary breast cancer,Y Oji,Y Miyoshi,E Kiyotoh,S Koga,Y Nakano,A Ando,N Hosen,A Tsuboi,M Kawakami,K Ikegame,Y Oka,H Ogawa,S Noguchi,H Sugiyama,JAPANESE JOURNAL OF CLINICAL ONCOLOGY,OXFORD UNIV PRESS,Vol. 34,No. 2,p. 74-77,2004年02月,研究論文(学術雑誌)
  • WT1 peptide-based immunotherapy for patients with lung cancer: Report of two cases,A Tsuboi,Y Oka,T Osaki,T Kumagai,Tachibana, I,S Hayashi,M Murakami,H Nakajima,OA Elisseeva,W Fei,T Masuda,M Yasukawa,Y Oji,M Kawakami,N Hosen,K Ikegame,S Yoshihara,K Udaka,S Nakatsuka,K Aozasa,L Kawase,H Sugiyama,MICROBIOLOGY AND IMMUNOLOGY,CENTER ACADEMIC PUBL JAPAN,Vol. 48,No. 3,p. 175-184,2004年,研究論文(学術雑誌)
  • Monitoring minimal residual disease in leukemia using real-time quantitative polymerase chain reaction for Wilms tumor gene (WT1),H Tamaki,M Mishima,M Kawakami,A Tsuboi,EH Kim,N Hosen,K Ikegame,M Murakami,T Fujioka,T Masuda,Y Taniguchi,S Nishida,K Osumi,T Soma,Y Oji,Y Oka,Kawase, I,H Sugiyama,H Ogawa,INTERNATIONAL JOURNAL OF HEMATOLOGY,CARDEN JENNINGS PUBL CO LTD,Vol. 78,No. 4,p. 349-356,2003年11月,研究論文(学術雑誌)
  • Overexpression of the Wilms' tumor gene WT1 in colorectal adenocarcinoma,Y Oji,H Yamamoto,M Nomura,Y Nakano,A Ikeba,S Nakatsuka,S Abeno,E Kiyotoh,T Jomgeow,M Sekimoto,R Nezu,Y Yoshikawa,Y Inoue,N Hosen,M Kawakami,A Tsuboi,Y Oka,H Ogawa,S Souda,K Aozasa,M Monden,H Sugiyama,CANCER SCIENCE,JAPANESE CANCER ASSOC,Vol. 94,No. 8,p. 712-717,2003年08月,研究論文(学術雑誌)
  • Overexpression of the Wilms' tumor gene WT1 in primary thyroid cancer,Y Oji,Y Miyoshi,S Koga,Y Nakano,A Ando,S Nakatsuka,A Ikeba,E Takahashi,N Sakaguchi,A Yokota,N Hosen,K Ikegame,M Kawakami,A Tsuboi,Y Oka,H Ogawa,K Aozasa,S Noguchi,H Sugiyama,CANCER SCIENCE,JAPANESE CANCER ASSOC,Vol. 94,No. 7,p. 606-611,2003年07月,研究論文(学術雑誌)
  • Wilms tumor gene peptide-based immunotherapy for patients with overt leukemia from myelodysplastic syndrome (MDS) or MDS with myelofibrosis,Y Oka,A Tsuboi,M Murakami,M Hirai,N Tominaga,H Nakajima,OA Elisseeva,T Masuda,A Nakano,M Kawakami,Y Oji,K Ikegame,N Hosen,K Udaka,M Yasukawa,H Ogawa,L Kawase,H Sugiyama,INTERNATIONAL JOURNAL OF HEMATOLOGY,CARDEN JENNINGS PUBL CO LTD,Vol. 78,No. 1,p. 56-61,2003年07月,研究論文(学術雑誌)
  • Successful treatment of bcr/abl-positive acute mixed lineage leukemia by unmanipulated bone marrow transplantation from an HLA-haploidentical (3-antigen-mismatched) cousin,K Ikegame,C Mukouchi,A Kunitomi,Y Konaka,M Kawakami,S Nishida,Y Taniguchi,T Fujioka,T Masuda,M Murakami,N Hosen,EH Kim,A Tsuboi,Y Oji,Y Oka,H Sugiyama,Kawase, I,H Ogawa,BONE MARROW TRANSPLANTATION,NATURE PUBLISHING GROUP,Vol. 31,No. 12,p. 1165-1168,2003年06月,研究論文(学術雑誌)
  • The lck promoter-driven expression of the Wilms tumor gene WT1 blocks intrathymic differentiation of T-lineage cells,H Li,Y Oka,A Tsuboi,T Yamagami,T Miyazaki,S Yusa,K Kawasaki,Y Kishimoto,M Asada,H Nakajima,K Kanato,S Nishida,T Masuda,M Murakami,N Hosen,M Kawakami,H Ogawa,F Melchers,Kawase, I,Y Oji,H Sugiyama,INTERNATIONAL JOURNAL OF HEMATOLOGY,CARDEN JENNINGS PUBL CO LTD,Vol. 77,No. 5,p. 463-470,2003年06月,研究論文(学術雑誌)
  • The effect on the proliferation and apoptosis of alloreactive T cells of cell dose in a murine MHC-mismatched hematopoietic cell transplantation model,T Fujioka,Y Taniguchi,T Masuda,S Nishida,K Ikegame,M Kawakami,A Tsuboi,N Hosen,M Murakami,Y Oji,Y Oka,H Sugiyama,Kawase, I,H Ogawa,TRANSPLANT IMMUNOLOGY,ELSEVIER SCIENCE BV,Vol. 11,No. 2,p. 187-195,2003年04月,研究論文(学術雑誌)
  • The usefulness of monitoring WT1 gene transcripts for the prediction and management of relapse following allogeneic stem cell transplantation in acute type leukemia,H Ogawa,H Tamaki,K Ikegame,T Soma,M Kawakami,A Tsuboi,EH Kim,N Hosen,M Murakami,T Fujioka,T Masuda,Y Taniguchi,S Nishida,Y Oji,Y Oka,H Sugiyama,BLOOD,AMER SOC HEMATOLOGY,Vol. 101,No. 5,p. 1698-1704,2003年03月,研究論文(学術雑誌)
  • Overexpression of the Wilms' tumor gene WT1 in human bone and soft-tissue sarcomas,T Ueda,Y Oji,N Naka,Y Nakano,E Takahashi,S Koga,M Asada,A Ikeba,S Nakatsuka,S Abeno,N Hosen,Y Tomita,K Aozasa,N Tamai,A Myoui,H Yoshikawa,H Sugiyama,CANCER SCIENCE,JAPANESE CANCER ASSOC,Vol. 94,No. 3,p. 271-276,2003年03月,研究論文(学術雑誌)
  • Enhanced induction of human WT1-specific cytotoxic T lymphocytes with a 9-mer WT1 peptide modified at HLA-A*2402-binding residues,A Tsuboi,Y Oka,K Udaka,M Murakami,T Masuda,A Nakano,H Nakajima,M Yasukawa,A Hiraki,Y Oji,M Kawakami,N Hosen,T Fujioka,F Wu,Y Taniguchi,S Nishida,M Asada,H Ogawa,Kawase, I,H Sugiyama,CANCER IMMUNOLOGY IMMUNOTHERAPY,SPRINGER-VERLAG,Vol. 51,No. 11-12,p. 614-620,2002年12月,研究論文(学術雑誌)
  • Overexpression of the Wilms' tumor gene WT1 in de novo lung cancers,Y Oji,S Miyoshi,H Maeda,S Hayashi,H Tamaki,SI Nakatsuka,M Yao,E Takahashi,Y Nakano,H Hirabayashi,Y Shintani,Y Oka,A Tsuboi,N Hosen,M Asada,T Fujioka,M Murakami,K Kanato,M Motomura,EH Kim,M Kawakami,K Ikegame,H Ogawa,K Aozasa,Kawase, I,H Sugiyama,INTERNATIONAL JOURNAL OF CANCER,WILEY-LISS,Vol. 100,No. 3,p. 297-303,2002年07月,研究論文(学術雑誌)
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特許・実用新案・意匠

  • 抗体,保仙 直毅,特願2015-159240,出願日:2015年08月11日
  • 抗体,保仙 直毅,特願2015-158414,出願日:2015年08月10日
  • 形質細胞の腫瘍性増殖をきたす疾患の治療薬,保仙 直毅,特許5566374,特願2009-096388,出願日:2009年04月10日

受賞

  • 若手研究奨励賞,保仙 直毅,日本白血病研究基金,2007年